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2399], 'drug': [176, 283, 1156], 'development.': [177], 'This': [178, 547, 981], 'article': [179], 'will': [180], 'briefly': [181], 'summarize': [182], 'findings': [184], 'preclinical': [186, 1452], 'clinical': [188, 352, 733, 767, 793, 1340, 1454, 1510, 1903, 2677, 2732, 2830], 'studies': [189, 1341], 'evaluating': [190], 'therapeutic': [192, 315, 576, 775, 1445, 1515, 2180, 2515], 'side-effect': [194, 720], 'profile': [195], 'as': [198, 752, 877, 922, 973, 1115, 1192, 1489, 1553, 1860, 2201, 2598], 'pharmacotherapies': [199, 580, 2202], 'pain.Neuropathic': [202], 'painNeuropathic': [203], 'pain': [204, 225, 248, 258, 277, 340, 367, 394, 516, 603, 689, 841, 857, 869, 914, 965, 985, 1044, 1078, 1160, 1177, 1234, 1338, 1450, 1530, 1545, 2046, 2177, 2231, 2256, 2406, 2436, 2543, 2671, 2724, 2753, 2793, 2820], 'caused': [206, 249, 266], 'a': [208, 350, 610, 619, 644, 664, 684, 810, 874, 953, 976, 1037, 1139, 1369, 1444, 1606, 1698, 1727, 1902, 1945, 1982, 2008, 2014, 2075, 2370, 2439, 2514, 2546, 2648, 2674, 2699, 2728, 2776, 2905], 'lesion': [210], 'or': [211, 265, 273, 433, 694, 755, 777, 900, 969, 1032, 1472, 1522, 1552, 1597, 1603, 1610, 1617, 2896, 2902, 2909, 2916], 'dysfunction': [212], 'nervous': [215], '[10].': [217], 'Spontaneous': [218], '(ongoing,': [219], 'paroxysm)': [220], 'evoked': [222, 2491], 'types': [223, 274], '(hyperalgesia': [226], 'allodynia)': [228], 'present': [230, 1673, 2051], '[11].': [231, 270], 'Hyperalgesia': [232], 'refers': [233, 246], 'increase': [236], 'response': [238, 2800], 'stimuli': [240, 251], 'that': [241, 252, 337, 532, 566, 623, 630, 786, 943, 1317, 1420, 1546, 1677, 1730, 2227], 'normally': [242, 254], 'produces': [243, 643, 683, 2228, 2571], 'pain.': [244, 298, 583, 833, 1921, 1950, 1986, 2019, 2115, 2339, 2524, 2582], 'Allodynia': [245], 'painful.': [256], 'Neuropathic': [257, 1900], 'may': [259, 278, 465, 487, 573, 780], 'arise': [260], 'from': [261, 306, 935, 1624, 2206, 2923], 'illness,': [262], 'be': [263, 466], 'drug-induced': [264], 'toxin': [268], 'exposure': [269], 'Different': [271, 374], 'patients': [272, 319, 843, 917, 933, 1041, 1120, 1148], 'respond': [279], 'differently': [280], 'standard': [282], 'interventions.': [284], 'NSAIDs': [285, 863], '[12],': [286], 'antidepressants,': [287, 1352], 'anticonvulsants': [288], 'opioids': [290, 322], '[11,12]': [291], 'all': [293, 391, 597, 1363], 'used': [294], 'treat': [296, 1133], 'However,': [299, 460, 526, 736, 1266, 1331], 'no': [300, 1023, 1523, 1593, 2892], 'single': [301, 954], 'provides': [303, 836], 'complete': [304], 'relief': [305, 341], 'pain,': [308, 972, 1053], 'adverse': [310, 346, 940, 1252, 1260, 1268, 1295, 1307, 1467], 'side': [311, 347, 469, 478, 521, 563, 571, 697, 778, 950, 991, 1203, 1315, 1343, 1366, 1387, 1468, 1487, 1518], 'effects': [312, 348, 464, 479, 522, 572, 698, 717, 779, 946, 992, 1002, 1106, 1111, 1204, 1316, 1344, 1367, 1388, 1436, 1469, 1488, 1519, 2003, 2137, 2574, 2772], 'limit': [313, 569], 'efficacy.': [316], 'For': [317, 584], 'example,': [318, 585], 'treated': [320, 1284], 'with': [321, 618, 622, 705, 718, 809, 844, 861, 907, 1016, 1042, 1069, 1149, 1305, 1310, 1320, 1365, 1463, 1600, 1605, 1613, 2899, 2904, 2912], 'develop': [323], 'sedation,': [324], 'nausea,': [325], 'constipation,': [326], 'respiratory': [327, 1426], 'depression,': [328], 'tolerance': [329, 654, 693], 'hyperalgesia': [331, 359, 455, 1941, 2461], '[101].': [332], 'Identification': [333, 1668, 1836], 'alternative': [335], 'therapeutics': [336], 'provide': [338], 'adequate': [339], 'absence': [344], 'remains': [349], 'strong': [351], 'need.Preclinical': [353], 'studiesCannabinoids': [354], 'efficacious': [356], 'suppressing': [358, 601, 1336], 'allodynia': [361, 458, 617, 651, 930, 1056, 1087, 1100, 1943], 'animal': [363, 404, 605], 'models': [364, 405, 428, 510, 539, 606, 2407, 2577], 'through': [368, 2545], 'mechanisms': [372], '[13–20].': [373], 'classes': [375, 723, 1394], '(i.e.,': [378, 410, 448, 1434, 1470], 'synthetic': [379, 753, 1126, 1937], 'endocannabinoids,': [380], 'agonists,': [382, 385, 1494], 'mixed': [383, 444, 626], 'CB1/CB2': [384, 446], 'agonists': [387, 447, 513, 595, 1478, 2143, 2597], 'modulators)': [390], 'suppress': [392, 453, 1448], 'behavior': [395, 2437], 'animals': [397], '[21].': [398, 459, 782, 824], 'Efficacy': [399], 'has': [400, 497], 'been': [401, 499, 788, 828], 'demonstrated': [402], 'traumatic': [407], 'nerve': [408, 416, 421, 441, 648, 2264, 2286], 'injury': [409, 413, 442], 'chronic': [411, 1374, 1920, 2402, 2696, 2796], 'constriction': [412], '[22],': [414], 'partial': [415, 1644, 2262], 'ligation': [417, 422, 2287], '[23]': [418], 'spinal': [420, 2285, 2431], '[24]': [423], 'models)': [424], 'neuropathy': [427, 503, 509, 847, 1221, 2281], 'produced': [429, 2258, 2282], 'metabolic': [431, 589], 'challenges': [432], 'toxins': [434], '(streptozotocin-': [435], 'chemotherapy-induced': [437, 1134, 1229], 'neuropathy)': [438, 505, 1230], '[21].In': [439], 'rodent': [440, 538, 2576], 'models,': [443], 'WIN55,212-2,': [449], 'CP55,940': [450], 'HU-210)': [452], 'thermal': [454], 'mechanical': [457, 616, 650, 929, 1086], 'resultant': [462], 'accompanied': [467], 'effects.': [470, 951], 'activation': [473, 1322, 2425, 2463], 'can': [474, 558], 'lead': [475], '(e.g.,': [480, 1270, 1355, 1532], 'hypoactivity,': [481, 1754], 'hypothermia': [482], 'catalepsy)': [484], '[25],': [485], 'which': [486, 702], 'translate': [488, 559], 'into': [489, 560], 'psychoactivity': [490], 'humans.': [492, 1508], 'Antinociceptive': [493], 'efficacy': [494, 535, 731, 776, 1334, 1462, 1506], 'reported': [500], 'toxin-induced': [502], '(chemotherapy-induced': [504], 'streptozotocin-induced': [507], 'diabetic': [508, 1220], '[21].Cannabinoid': [511], 'attenuate': [514], '[16,19,26–31]': [517], 'without': [518, 691, 1071], 'attributed': [523, 1491], 'CB1[32].': [525], 'it': [527], 'important': [529, 550], 'verify': [531], 'antihyperalgesic': [534, 1977], 'observed': [536], 'translates': [540], 'humans': [542, 1329], 'species-specific.': [546], 'particularly': [549, 673, 1441], 'because': [551, 1411], 'even': [552], 'low': [553, 1402], 'levels': [554], 'occupancy': [557], 'unwanted': [561, 695], 'effects.Other': [564], 'strategies': [565, 1504, 2592], 'attempt': [567], 'enhance': [574], 'ratio': [577, 812], 'drugs': [586], 'targeting': [587], 'peripherally-acting': [594], '[33,34]': [596], 'show': [598, 1333, 1505, 1514, 1540], 'promise': [599, 1541], '(see': [607], '[35]).': [608], 'AZ11713908,': [609], 'peripherally': [611, 2566], 'restricted': [612, 2567], 'agonist,': [614, 2012], 'reduces': [615], 'magnitude': [620], 'comparable': [621, 1390], 'agonist': [628, 2106, 2570], 'WIN55,212-2': [629, 1939], 'penetrates': [631], '[34].': [634], 'An': [635, 2276], 'irreversible': [636], 'inhibitor': [637, 667], '2-AG-hydrolyzing': [640], 'enzyme': [641], 'CB1-mediated': [645, 685], 'suppression': [646, 686], 'injury-induced': [649], 'undergoes': [653], 'following': [655], 'repeated': [656], 'administration': [657], '[36].': [658], 'recent': [660], 'identification': [661, 2790], 'URB937,': [663], 'brain': [665, 681, 1728], 'impermeant': [666], 'hydrolase,': [671], 'noteworthy': [674], '[33].': [675, 699], 'URB937': [676], 'elevates': [677], 'anandamide': [678], 'outside': [679], 'behavior,': [690], 'producing': [692], 'Adjunctive': [700], 'treatments,': [701], 'combine': [703], 'other': [706, 1232, 1594, 2893], 'agents,': [708], 'offer': [710], 'potential': [712, 2181], 'produce': [714, 1481], 'synergistic': [715], 'antinociceptive': [716], 'limited': [719], 'profiles.Clinical': [721], 'studiesDifferent': [722], 'cannabinoid-based': [725, 784, 1512], 'medications': [726, 989, 1066, 1396, 1513, 1531], 'being': [728], 'evaluated': [729, 1240], 'trials': [734, 768, 1214, 1560, 2831], '[102].': [735], 'cannabis': [737, 807, 835, 853, 911, 959, 2668, 2694], 'contains': [738], 'approximately': [739], '460': [740], 'chemically': [741], 'distinct': [742], 'constituents,': [743], 'and,': [744], 'consequently,': [745], 'smoked': [746, 796], 'marijuana': [747, 1407], 'same': [751, 1483], 'Δ9-THC': [754, 758, 814, 1299, 1302], 'mixtures': [756], 'cannabidiol.': [760], 'Therefore,': [761], 'different': [762, 1393], 'chemical': [763], 'compounds': [764, 785, 826, 1572], 'tested': [765, 789], 'identical,': [771], 'so': [773], 'differ': [781, 1282], 'have': [787, 827, 1401, 1592, 2891], 'most': [790, 1201, 1292], 'extensively': [791], 'settings': [794], 'include': [795], 'Sativex®': [798], '(GW': [799], 'Pharmaceuticals,': [800, 820], 'UK;': [801], 'oral': [803, 1301], 'mucosal': [804], 'spray': [805], 'containing': [806], 'extracts': [808], '1:1': [811], 'cannabidiol),': [816], 'dronabinol': [817], '(Marinol®;': [818], 'Solvay': [819], 'Belgium)': [821], 'nabilone': [823, 1144, 1173, 1218, 1356], 'These': [825], 'shown': [829], 'reduce': [831], 'Smoked': [834, 910, 2666, 2693], 'notable': [837], 'improvement': [838], 'HIV': [845, 849, 896, 916], 'sensory-related': [846], '[37,38].': [848], 'patients,': [850], 'prior': [851], 'treatment,': [854], 'had': [855], 'intractable': [856, 1548], 'despite': [858], 'concurrent': [859, 988, 1065], 'opioids,': [862], 'adjuvants': [865], '[38].': [866, 890, 909], 'Cannabis': [867, 2642], 'improved': [868, 1077, 1103, 1175, 1180, 1438], 'throughout': [870], 'both': [871, 1098], 'phases': [872], 'crossover': [875, 2676], 'study,': [876, 1040, 1143], 'measured': [878, 923, 974], 'descriptor': [881], 'differential': [882], 'scale': [883, 888, 979], 'visual': [886], 'analog': [887], '(VAS)': [889], 'No': [891, 932], 'changes': [892, 1024], 'blood': [894, 901, 1034], 'pressure,': [895], 'RNA': [897], '(viral': [898], 'load)': [899], 'CD4': [902], 'lymphocytes': [903], 'detected': [905], 'compared': [906, 1309], 'placebo': [908, 1286], 'reduced': [913], 'greater': [919], 'than': [920, 1525], '30%,': [921], 'VAS,': [925], 'decreased': [927, 964, 1094], 'capsaicin-induced': [928], '[37].': [931], 'withdrew': [934], 'study': [937, 982], 'due': [938], 'events,': [941], 'indicating': [942], 'outweighed': [947], 'any': [948, 1601, 2900], 'negative': [949], 'Strikingly,': [952], 'inhalation': [955], 'THC': [957], 'herbal': [958], '(25': [960], 'mg': [961, 1169], '9.4%)': [963], 'intensity': [966], 'post-traumatic': [968], 'post-surgery-induced': [970], 'numeric': [977], 'rating': [978, 1083], '[39].': [980, 993], 'thoroughly': [983], 'assessed': [984, 1058], 'intensity,': [986], 'sleep,': [987], 'A': [994, 1694, 1720, 2032, 2222, 2250, 2565, 2788], 'total': [995], '248': [997], 'mild': [998], 'six': [1000], 'moderate': [1001], 'detected.': [1004], 'Headache,': [1005], 'dry': [1006, 1207], 'eyes,': [1007], 'burning': [1008], 'sensation,': [1009], 'dizziness,': [1010], 'numbness': [1011], 'cough': [1013], 'associated': [1015, 1304, 1319, 1364], 'high': [1018, 2009], 'dose': [1019], 'vital': [1028, 1422], 'signs,': [1029], 'heart': [1030, 1423], 'rate': [1031, 1424], 'renal': [1033], 'function': [1035], '[39].In': [1036], 'randomized,': [1038, 1140, 2675], 'double-blind': [1039], 'peripheral': [1046, 1972, 2223, 2280, 2358, 2391, 2465, 2547], 'origin': [1047], 'given': [1049, 1146], 'oromucosal': [1050], 'Sativex,': [1051], 'sleep': [1054, 1102], '[40].': [1059, 1104, 1121], 'Patients': [1060, 1166], 'continue': [1064], 'self-medicate': [1068], 'Sativex': [1070, 1076, 1227, 2720], 'exceeding': [1072], 'limits.': [1075], 'based': [1079], 'on': [1080, 2144], 'numerical': [1082], 'scale.': [1084], 'Dynamic': [1085], '(measured': [1088], 'brushing': [1090], 'affected': [1092], 'skin)': [1093], '20%,': [1096], 'punctate': [1099], 'Side': [1105], 'included': [1107], 'sedation': [1108], 'gastrointestinal': [1110], 'classified': [1114], 'severe': [1116], '10–11%': [1118], 'Nabilone,': [1122], 'orally': [1124], 'administered': [1125, 1167], 'cannabinoid,': [1127], 'approved': [1129], 'Canada': [1131], 'nausea': [1135], 'vomiting.': [1137], 'In': [1138, 1247, 1509], 'double-blind,': [1141, 2730], 'placebo-controlled': [1142, 2650, 2731], 'was': [1145, 1290, 1629, 2928], 'fibromyalgia': [1150, 1184], 'order': [1152], 'determine': [1154, 1501], 'whether': [1155, 1502], 'would': [1158], 'improve': [1159], 'quality': [1162], 'life': [1164], '[41].': [1165, 1199, 1212], '1': [1168], 'twice': [1170], 'daily': [1171, 1189], 'showed': [1174], 'VAS': [1176], 'ratings': [1178], 'scores': [1181], 'impact': [1185], 'questionnaire': [1186], '(which': [1187], 'evaluates': [1188], 'functions': [1190], 'such': [1191], 'depression': [1193], 'physical': [1195], 'function,': [1196], 'among': [1197, 1325], 'others)': [1198], 'common': [1202, 1293], 'drowsiness,': [1206], 'mouth,': [1208], 'vertigo': [1209], 'ataxia': [1211], 'Clinical': [1213, 1559, 2814], 'ongoing': [1216], '(for': [1219, 1228], 'phantom': [1223], 'limb': [1224], 'pain)': [1225], 'syndromes': [1235, 1376, 2798], '[102].A': [1236], 'systematic': [1237, 2777], 'review': [1238], 'recently': [1239], 'safety': [1242, 1569], 'medical': [1244, 2774], '[42].': [1246, 1265, 1288, 1297], 'review,': [1249], '4615': [1250], '(96.6%)': [1251], 'events': [1253, 1261, 1269, 1308], 'considered': [1256, 1263], 'serious': [1257, 1264, 1267], '164': [1259], 'relapse': [1271], 'multiple': [1273], 'sclerosis,': [1274], 'vomiting': [1275], 'urinary': [1277], 'tract': [1278], 'infection)': [1279], 'did': [1280], 'between': [1283], 'groups': [1287], 'Dizziness': [1289], 'nonserious': [1294], 'event': [1296], 'Oromucosal': [1298], 'more': [1306, 1496], 'controls': [1311], '[42].The': [1312], 'presence': [1313, 1384, 1465], 'indisputable': [1324], 'cannabis-based': [1326], 'treatments': [1327, 1551], '[21,42].': [1330], 'unique': [1347], 'cannabinoids.': [1349], 'Gabapentinoids,': [1350], 'tricyclic': [1351, 1534], 'anticonvulsants,': [1353], 'Sativex)': [1358], 'topical': [1360], 'agents': [1361], 'prospective': [1370, 2789], 'evaluation': [1371], 'specific': [1373, 2795], 'polyneuropathy': [1375, 2797], 'responses': [1379, 2145], 'pharmacological': [1381, 2802], 'therapies;': [1382], 'intolerable': [1386], 'across': [1391], 'these': [1392, 1503, 1571], '[43].': [1397], 'Importantly,': [1398], 'however,': [1399], 'toxicity.': [1403], 'High': [1404], 'doses': [1405], 'lethal': [1410], 'paucity': [1414], 'brainstem': [1418, 1841], 'regions': [1419], 'control': [1421], 'functions.': [1427], 'Moreover,': [1428], 'several': [1429], 'aspects': [1430], 'pharmacology': [1433], 'antiemetic': [1435], 'sleep)': [1439], 'beneficial': [1442], 'intervention.ConclusionCannabinoids': [1446], 'effectively': [1447], 'studies.': [1455], 'challenge': [1457], 'balance': [1460], 'dizziness': [1471], 'sedation).': [1473], 'Endocannabinoid': [1474], 'modulators': [1475], 'do': [1479], 'spectrum': [1484], 'those': [1490, 1526, 1625, 2234, 2924], 'work': [1497], 'necessary': [1499], 'settings,': [1511], 'efficacy,': [1516], 'tolerable': [1521], 'worse': [1524], 'conventional': [1528, 1550], 'gabapentanoids,': [1533], 'antidepressants': [1535], 'anticonvulsants).': [1537], 'Thus,': [1538], 'managing': [1543], 'adjunct': [1555], 'existing': [1557], 'medications.': [1558], 'needed': [1562], 'evaluate': [1564], 'long-term': [1566], 'effectiveness': [1567], 'humans.Financial': [1574], 'competing': [1576, 2875], 'interests': [1577, 2876], 'disclosureAndrea': [1578, 2877], 'Hohmann': [1580, 1746, 2198, 2354, 2422, 2479, 2509, 2879], 'supported': [1582, 2829, 2881], 'NIH': [1585, 2884], 'grants': [1586, 2885], 'DA028200': [1587, 2886], 'DA021644.': [1589, 2888], 'authors': [1591, 2890], 'relevant': [1595, 2894], 'affiliations': [1596, 2895], 'financial': [1598, 1607, 1611, 2897, 2906, 2910], 'involvement': [1599, 1786, 2898], 'organization': [1602, 2901], 'entity': [1604, 2903], 'interest': [1608, 2907], 'conflict': [1612, 2911], 'subject': [1615, 2914], 'matter': [1616, 2915], 'materials': [1618, 2917], 'discussed': [1619, 2918], 'manuscript': [1622, 2921], 'apart': [1623, 2922], 'disclosed.No': [1626, 2925], 'writing': [1627, 2926], 'assistance': [1628, 2927], 'utilized': [1630, 2929], 'production': [1633, 2932], 'manuscript.Bibliography1': [1636], 'Gaoni': [1637], 'Y,': [1638], 'Mechoulam': [1639, 1660], 'R:': [1640, 1899], 'Isolation,': [1641], 'structure': [1642, 1725], 'synthesis': [1645], 'active': [1648], 'constituent': [1649, 1729], 'hashish.': [1651], 'J.': [1652, 1791, 1820, 1923, 1952, 2090, 2117, 2157, 2374, 2411, 2500, 2526, 2601, 2756], 'Am.': [1653], 'Chem.': [1654], 'Soc.86,1646–1647': [1655], '(1964).Crossref,': [1656], 'CAS,': [1657, 1686, 1712, 1739, 1770, 1795, 1824, 1848, 1870, 1927, 1956, 1990, 2024, 2062, 2094, 2121, 2193, 2215, 2241, 2269, 2294, 2319, 2343, 2378, 2415, 2447, 2472, 2504, 2530, 2554, 2586, 2605, 2631, 2655, 2682, 2737, 2760], 'Google': [1658, 1687, 1713, 1740, 1771, 1796, 1825, 1849, 1871, 1911, 1928, 1957, 1991, 2025, 2063, 2095, 2122, 2161, 2194, 2216, 2242, 2270, 2295, 2320, 2344, 2379, 2416, 2448, 2473, 2505, 2531, 2555, 2587, 2606, 2632, 2656, 2683, 2706, 2738, 2761, 2782, 2807], 'Scholar2': [1659], 'R,': [1661, 2247], 'Ben-Shabat': [1662], 'S,': [1663, 1692, 1854, 2127, 2768], 'Hanus': [1664, 1717], 'L': [1665], 'et': [1666, 1695, 1721, 1779, 1804, 1834, 1965, 2033, 2071, 2303, 2387, 2456, 2539, 2563, 2614, 2640, 2664, 2691], 'al.:': [1667, 1696, 1722, 1780, 1805, 1835, 1966, 2034, 2072, 2304, 2388, 2457, 2540, 2564, 2615, 2641, 2665, 2692], '2-monoglyceride,': [1672], 'canine': [1675], 'gut,': [1676], 'binds': [1678, 1731], 'Biochem.': [1682, 1706, 2315], 'Pharmacol.50(1),83–90': [1683], '(1995).Crossref,': [1684, 1710], 'Medline,': [1685, 1711, 1738, 1769, 1794, 1823, 1847, 1869, 1910, 1926, 1955, 1989, 2023, 2061, 2093, 2120, 2160, 2192, 2214, 2240, 2268, 2293, 2318, 2342, 2377, 2414, 2446, 2471, 2503, 2529, 2553, 2585, 2604, 2630, 2654, 2681, 2705, 2736, 2759, 2781, 2806], 'Scholar3': [1688], 'Sugiura': [1689], 'T,': [1690, 2347, 2688, 2764], 'Kondo': [1691], 'Sukagawa': [1693], '2-arachidonoylglycerol:': [1697], 'possible': [1699, 1784], 'ligand': [1703], 'brain.': [1705], 'Biophys.': [1707], 'Res.': [1708], 'Commun.215(1),89–97': [1709], 'Scholar4': [1714], 'Devane': [1715], 'WA,': [1716, 1894], 'L,': [1718, 2743], 'Breuer': [1719], 'Isolation': [1723], 'receptor.': [1735, 1818], 'Science258(5090),1946–1949': [1736], '(1992).Crossref,': [1737, 2292], 'Scholar5': [1741], 'Zimmer': [1742, 1744], 'A,': [1743, 1960, 1962, 2353, 2421, 2451, 2478], 'AM,': [1745, 2351], 'AG,': [1747, 2419], 'Herkenham': [1748], 'M,': [1749, 1774, 1831, 2100, 2384], 'Bonner': [1750], 'TI:': [1751], 'Increased': [1752], 'mortality,': [1753], 'hypoalgesia': [1756], 'knockout': [1761], 'mice.': [1762], 'Proc.': [1763, 2055], 'Natl': [1764, 2056], 'Acad.': [1765, 2057], 'Sci.': [1766, 2058], 'USA96(10),5780–5785': [1767], '(1999).Crossref,': [1768], 'Scholar6': [1772], 'Beltramo': [1773], 'Bernardini': [1775], 'N,': [1776, 2323, 2810], 'Bertorelli': [1777], 'R': [1778, 2538], 'receptor-mediated': [1782], 'antihyperalgesia:': [1783], 'direct': [1785], 'neural': [1788], 'mechanisms.': [1789], 'Eur.': [1790, 1819, 2089, 2116, 2156], 'Neurosci.23(6),1530–1538': [1792], '(2006).Crossref,': [1793, 1868], 'Scholar7': [1797], 'Buckley': [1798], 'NE,': [1799], 'Mccoy': [1800], 'KL,': [1801], 'Mezey': [1802], 'E': [1803], 'Immunomodulation': [1806], 'absent': [1810], 'mice': [1812], 'deficient': [1813], 'Pharmacol.396(2–3),141–149': [1821], '(2000).Crossref,': [1822], 'Scholar8': [1826], 'Van': [1827], 'Sickle': [1828], 'MD,': [1829, 2066], 'Duncan': [1830], 'Kingsley': [1832], 'PJ': [1833], 'functional': [1838, 2077, 2621], 'characterization': [1839], 'Science310(5746),329–332': [1845], '(2005).Crossref,': [1846, 2119, 2159], 'Scholar9': [1850], 'Pacher': [1851], 'P,': [1852], 'Batkai': [1853], 'Kunos': [1855], 'G:': [1856], 'emerging': [1862], 'target': [1863, 2516], 'pharmacotherapy.': [1865], 'Pharmacol.': [1866, 1907, 2314], 'Rev.58(3),389–462': [1867], 'Scholar10': [1872], 'Classification': [1873], 'Chronic': [1875, 1879, 2616], 'Pain:': [1876], 'Descriptions': [1877], 'Pain': [1880, 1885, 2813], 'Syndromes': [1881], 'Definitions': [1883], 'Terms.': [1886], 'Merskey': [1887], 'H,': [1888, 2030], 'Bogduk': [1889], 'N': [1890], '(Eds).': [1891], 'IASP': [1892], 'Press,': [1893], '(1994).Google': [1896], 'Scholar11': [1897], 'Baron': [1898], 'perspective.': [1904], 'Handb.': [1905], 'Exp.': [1906], '(194),3–30': [1908], '(2009).Crossref,': [1909, 2213, 2603, 2680], 'Scholar12': [1912], 'Park': [1913], 'HJ,': [1914], 'Moon': [1915], 'DE:': [1916], 'Pharmacologic': [1917], 'management': [1918, 2817], 'Korean': [1922], 'Pain23(2),99–108': [1924], '(2010).Crossref,': [1925, 2552, 2584, 2629, 2704], 'Scholar13': [1929], 'Bridges': [1930], 'D,': [1931], 'Ahmad': [1932], 'K,': [1933, 2745], 'Rice': [1934], 'AS:': [1935], 'attenuates': [1940], 'rat': [1946, 2015, 2226, 2440], 'model': [1947, 1983, 2016, 2112, 2253, 2278, 2441], 'Br.': [1951, 2373, 2410, 2499, 2525, 2600], 'Pharmacol.133(4),586–594': [1953], '(2001).Crossref,': [1954, 1988], 'Scholar14': [1958], 'Fox': [1959], 'Kesingland': [1961], 'Gentry': [1963], 'C': [1964], 'role': [1968, 2078, 2170], 'central': [1970], 'cannabinoid1': [1973], 'activity': [1978, 2107, 2400], 'Pain92(1–2),91–100.': [1987], 'Scholar15': [1992], 'Herzberg': [1993], 'U,': [1994], 'Eliav': [1995], 'E,': [1996], 'Bennett': [1997, 2218], 'GJ,': [1998, 2219], 'Kopin': [1999], 'IJ:': [2000], 'R+-WIN': [2005], '55,212-2': [2006], 'mesylate,': [2007], 'affinity': [2010], 'Neurosci.': [2020], 'Lett.221(2–3),157–160': [2021], '(1997).Crossref,': [2022], 'Scholar16': [2026], 'Ibrahim': [2027, 2454], 'MM,': [2028], 'Deng': [2029], 'Zvonok': [2031, 2350], 'Activation': [2035, 2356, 2481], 'AM1241': [2041], 'inhibits': [2042], 'experimental': [2043, 2277], 'inhibition': [2047], 'CNS.': [2054], 'USA100(18),10529–10533': [2059], '(2003).Crossref,': [2060, 2445, 2470], 'Scholar17': [2064], 'Jhaveri': [2065], 'Elmes': [2067], 'SJ,': [2068], 'Richardson': [2069], 'D': [2070], 'Evidence': [2073], 'novel': [2076, 2251], 'thalamus': [2085], 'rats.': [2088, 2155, 2409, 2498], 'Neurosci.27(7),1722–1730': [2091], '(2008).Crossref,': [2092, 2528, 2758, 2780, 2805], 'Scholar18': [2096], 'Labuda': [2097], 'CJ,': [2098], 'Koblish': [2099], 'Little': [2101], 'PJ:': [2102], 'Cannabinoid': [2103, 2511], 'hindpaw': [2110], 'incision': [2111], 'postoperative': [2114], 'Pharmacol.527(1–3),172–174': [2118], 'Scholar19': [2123], 'Sagar': [2124], 'DR,': [2125, 2300], 'Kelly': [2126], 'Millns': [2128], 'PJ,': [2129, 2715], "O'Shaughnessey": [2130], 'CT,': [2131], 'Kendall': [2132], 'DA,': [2133], 'Chapman': [2134], 'V:': [2135], 'Inhibitory': [2136], 'DRG': [2147], 'neurons': [2148, 2152], 'dorsal': [2150], 'horn': [2151], 'Neurosci.22(2),371–379': [2158], 'Scholar20': [2162], 'Whiteside': [2163], 'GT,': [2164], 'Lee': [2165], 'GP,': [2166], 'Valenzano': [2167], 'KJ:': 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'Pain50(3),355–363': [2291], 'Scholar25': [2296], 'Martin': [2297], 'BR,': [2298], 'Compton': [2299], 'Thomas': [2301], 'BF': [2302], 'Behavioral,': [2305], 'biochemical,': [2306], 'molecular': [2308], 'modeling': [2309], 'evaluations': [2310], 'analogs.': [2313], 'Behav.40(3),471–478': [2316], '(1991).Crossref,': [2317], 'Scholar26': [2321], 'Clayton': [2322], 'Marshall': [2324], 'FH,': [2325], 'Bountra': [2326], 'C,': [2327, 2785], "O'Shaughnessy": [2328], 'CT:': [2329], 'implicated': [2336], 'inflammatory': [2338, 2368, 2403, 2460, 2521, 2579], 'Pain96(3),253–260': [2340], '(2002).Crossref,': [2341], 'Scholar27': [2345], 'Farthing': [2348], 'JN,': [2349], 'Makriyannis': [2352, 2420, 2477], 'suppresses': [2364, 2430, 2488, 2542], 'maintenance': [2366], 'nociception:': [2369], 'comparative': [2371], 'analysis.': [2372], 'Pharmacol.150(2),153–163': [2375], 'Scholar28': [2380], 'Hsieh': [2381], 'GC,': [2382], 'Pai': [2383], 'Chandran': [2385], 'P': [2386], 'Central': [2389], 'sites': [2392], 'action': [2394], 'mediated': [2398], 'Pharmacol.162(2),428–440': [2412], '(2011).Crossref,': [2413], 'Scholar29': [2417], 'Nackley': [2418], 'Selective': [2424], 'fos': [2432], 'protein': [2433], 'expression': [2434], 'inflammation.': [2443], 'Neuroscience119(3),747–757': [2444], 'Scholar30': [2449], 'Quartilho': [2450], 'Mata': [2452], 'HP,': [2453], 'MM': [2455], 'Inhibition': [2458], 'Anesthesiology99(4),955–960': [2469], 'Scholar31': [2474], 'nociception': [2490], 'chemotherapeutic': [2494], 'agent': [2495], 'vincristine': [2496], 'Pharmacol.152(5),765–777': [2501], 'Scholar32': [2506], 'Guindon': [2507], 'J,': [2508], 'receptors:': [2513], 'Pharmacol.153(2),319–334': [2527], 'Scholar33': [2532], 'Clapper': [2533], 'JR,': [2534], 'Moreno-Sanz': [2535], 'G,': [2536], 'Russo': [2537], 'initiation': [2544], 'mechanism.': [2549], 'Nat.': [2550, 2627], 'Neurosci.13(10),1265–1270': [2551], 'Scholar34': [2556], 'Yu': [2557], 'XH,': [2558], 'Cao': [2559], 'CQ,': [2560], 'Martino': [2561], 'robust': [2572], 'anti-nociceptive': [2573], 'Pain151(2),337–344': [2583], 'Scholar35': [2588], 'Pertwee': [2589], 'RG:': [2590], 'Emerging': [2591], 'exploiting': [2594], 'medicines.': [2599], 'Pharmacol.156(3),397–411': [2602], 'Scholar36': [2607], 'Schlosburg': [2608], 'JE,': [2609], 'Blankman': [2610], 'JL,': [2611], 'Long': [2612], 'JZ': [2613], 'blockade': [2619], 'causes': [2620], 'antagonism': [2622], 'system.': [2626], 'Neurosci.13(9),1113–1119': [2628], 'Scholar37': [2633], 'Abrams': [2634], 'DI,': [2635], 'Jay': [2636], 'CA,': [2637], 'Shade': [2638], 'SB': [2639], 'painful': [2644], 'HIV-associated': [2645], 'sensory': [2646], 'neuropathy:': [2647], 'randomized': [2649, 2700], 'trial.': [2651, 2678, 2702, 2733], 'Neurology68(7),515–521': [2652], 'Scholar38': [2657], 'Ellis': [2658], 'RJ,': [2659], 'Toperoff': [2660], 'W,': [2661], 'Vaida': [2662], 'F': [2663], 'medicinal': [2667], 'HIV:': [2673], 'Neuropsychopharmacology34(3),672–680': [2679], 'Scholar39': [2684], 'Ware': [2685, 2769], 'MA,': [2686], 'Wang': [2687, 2763], 'Shapiro': [2689, 2767], 'S': [2690], 'controlled': [2701], 'CMAJ182(14),E694–E701': [2703], 'Scholar40': [2707], 'Nurmikko': [2708], 'TJ,': [2709], 'Serpell': [2710], 'MG,': [2711], 'Hoggart': [2712], 'B,': [2713], 'Toomey': [2714], 'Morlion': [2716], 'BJ,': [2717], 'Haines': [2718], 'D:': [2719, 2747], 'successfully': [2721], 'treats': [2722], 'characterised': [2725], 'allodynia:': [2727], 'randomised,': [2729], 'Pain133(1–3),210–220': [2734], 'Scholar41': [2739], 'Skrabek': [2740], 'RQ,': [2741], 'Galimova': [2742], 'Ethans': [2744], 'Perry': [2746], 'Nabilone': [2748], 'fibromyalgia.': [2755], 'Pain9(2),164–173': [2757], 'Scholar42': [2762], 'Collet': [2765], 'JP,': [2766], 'MA:': [2770], 'Adverse': [2771], 'cannabinoids:': [2775], 'review.': [2778], 'CMAJ178(13),1669–1678': [2779], 'Scholar43': [2783], 'Toth': [2784], 'Au': [2786], 'S:': [2787], 'therapy.': [2803], 'Pain138(3),657–666': [2804], 'Scholar101': [2808], 'Attal': [2809], 'Finnerup': [2811], 'NB:': [2812], 'Updates:': [2815], 'Pharmacological': [2816], '(2010)': [2821], 'www.iasp-pain.org/AM/AMTemplate.cfm?Section=Clinical_Updates&SECTION=Clinical_Updates&CONTENTID=12215&TEMPLATE=/CM/ContentDisplay.cfmGoogle': [2822], 'Scholar102': [2823], 'Registry': [2824], 'federally': [2826], 'privately': [2828], 'conducted': [2832], 'around': [2837], 'world': [2839], 'www.clinicaltrials.govGoogle': [2840], 'ScholarFiguresReferencesRelatedDetailsCited': [2841], 'ByCannabis': [2842], 'Chemistry:': [2843], 'Cannabis,': [2846], 'Humans,': [2847], 'Other': [2849], 'Species': [2850], 'Vol.': [2851], 'STAY': [2855], 'CONNECTED': [2856], 'Metrics': [2857], 'History': [2858], 'Published': [2859, 2864], 'online': [2860], '7': [2861], 'March': [2862, 2867], '2011': [2863, 2868], 'print': [2866], 'Information©': [2869], 'Medicine': [2871], 'LtdKeywordsallodyniacannabinoidendocannabinoidhyperalgesianeuropathic': [2872], 'painFinancial': [2873], 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