Title: Microbial degradation of the phytosterol side-chain to 24-oxo products
Abstract: A mutant of the potent sterol degrader Mycobacteriun fortuitum (ATCC6842) has been isolated which is defective in its ability to degrade both the steroid nucleus and sterol side-chains that are branched at the 24-position. Bioconversions of phytosterol mixtures by this mutant resulted in the accumulation of the novel 24-oxo intermediates 9-hydroxy-27-nor-4-cholestene-3,24-dione (II) and 9-hydroxy-26,27-dinor-4-cholestene-3,24-dione (III). Under the same conditions, cholesterol is degraded mainly to 9-hydroxy-4-androstene-3,17-dione (I) by this organism.
Publication Year: 1980
Publication Date: 1980-12-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 18
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