Effect of Myriocin on Plasma Sphingolipid Metabolism and Atherosclerosis in apoE-deficient Mice

Name: Work Video:
Duration: 3 min 30 s
Mohammad Reza Hojjati; Zhiqiang Li; Hongwen Zhou; Song-Shan Tang; Chongmin Huan; Everlyn Ooi; Shendi Lu; Xian‐Cheng Jiang
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{'descriptor_ui': 'D014280', 'descriptor_name': 'Triglycerides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014280', 'descriptor_name': 'Triglycerides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m412348200', 'pdf_url': 'http://www.jbc.org/article/S0021925819304272/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15590644', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m412348200', 'pdf_url': 'http://www.jbc.org/article/S0021925819304272/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W154215136', 'https://openalex.org/W1551851929', 'https://openalex.org/W1748476074', 'https://openalex.org/W1984745753', 'https://openalex.org/W1986426214', 'https://openalex.org/W1990010834', 'https://openalex.org/W1993930518', 'https://openalex.org/W1996965660', 'https://openalex.org/W1997567789', 'https://openalex.org/W1998546556', 'https://openalex.org/W2000823512', 'https://openalex.org/W2003940208', 'https://openalex.org/W2006711474', 'https://openalex.org/W2010323829', 'https://openalex.org/W2010539762', 'https://openalex.org/W2011656212', 'https://openalex.org/W2019425261', 'https://openalex.org/W2028144999', 'https://openalex.org/W2031483029', 'https://openalex.org/W2034041660', 'https://openalex.org/W2036087370', 'https://openalex.org/W2041767551', 'https://openalex.org/W2048360543', 'https://openalex.org/W2062535842', 'https://openalex.org/W2088168837', 'https://openalex.org/W2131162885', 'https://openalex.org/W2134271396', 'https://openalex.org/W2135414036', 'https://openalex.org/W2144535813', 'https://openalex.org/W2152692033', 'https://openalex.org/W2157904413', 'https://openalex.org/W2169616751', 'https://openalex.org/W2239985133', 'https://openalex.org/W2328356063', 'https://openalex.org/W2345902056'], 'related_works': ['https://openalex.org/W2549041080', 'https://openalex.org/W2410319083', 'https://openalex.org/W2402243167', 'https://openalex.org/W2114765153', 'https://openalex.org/W2050123014', 'https://openalex.org/W2049444568', 'https://openalex.org/W2003579166', 'https://openalex.org/W1977320865', 'https://openalex.org/W1974695671', 'https://openalex.org/W1567111656'], 'abstract_inverted_index': {'Sphingolipids': [0, 248, 496], 'play': [1, 249], 'a': [2, 70, 76, 105, 129, 149, 174, 196, 250, 318, 324, 353, 377, 397, 422, 444, 682, 772, 809, 987, 1028, 1066, 1199, 1211, 1235, 1301, 1451, 1462, 1483, 1545, 1557, 1658, 1907, 1954, 2138, 2244, 2263, 2373, 2380, 2399, 2447, 2462, 2569, 2660, 2665, 2677, 2690, 2717, 2724, 2735, 2748, 2952, 2975, 2986, 3045, 3064, 3080, 3126, 3302, 3316, 3535, 3630, 4016, 4031], 'very': [3, 251], 'important': [4, 252, 597, 2081, 2774, 3453, 4320], 'role': [5, 253, 598, 606, 3186], 'in': [6, 80, 89, 108, 132, 137, 141, 158, 177, 199, 204, 208, 254, 328, 337, 356, 380, 385, 389, 406, 425, 447, 452, 456, 568, 599, 607, 623, 676, 808, 813, 935, 991, 994, 1195, 1213, 1228, 1237, 1240, 1339, 1461, 1524, 1822, 1830, 1882, 1902, 1953, 1982, 2084, 2099, 2118, 2133, 2243, 2281, 2394, 2446, 2457, 2568, 2587, 2617, 2669, 2683, 2696, 2728, 2741, 2754, 2790, 2800, 2811, 2824, 2834, 2981, 3027, 3159, 3172, 3193, 3216, 3255, 3331, 3367, 3534, 3583, 3613, 3764, 3806, 3848, 3854, 3889, 3948, 4030, 4072, 4169, 4200, 4237], 'cell': [7, 255, 502, 1114, 2615, 3803, 4235, 4261], 'membrane': [8, 256, 503], 'formation,': [9, 257, 504], 'signal': [10, 258, 505, 2085], 'transduction,': [11, 259, 506], 'and': [12, 36, 93, 98, 104, 119, 139, 162, 167, 173, 187, 206, 230, 260, 284, 341, 346, 352, 367, 387, 410, 415, 421, 435, 454, 478, 507, 510, 611, 643, 712, 762, 858, 861, 922, 1062, 1103, 1141, 1146, 1192, 1221, 1233, 1249, 1256, 1310, 1318, 1331, 1337, 1341, 1445, 1474, 1508, 1511, 1522, 1540, 1577, 1582, 1613, 1651, 1674, 1677, 1689, 1695, 1787, 1843, 1860, 1976, 1980, 1992, 2021, 2041, 2055, 2078, 2108, 2115, 2295, 2303, 2314, 2347, 2362, 2620, 2641, 2648, 2689, 2708, 2747, 2766, 2805, 2820, 2838, 2868, 2949, 2970, 3025, 3057, 3124, 3166, 3190, 3219, 3314, 3358, 3579, 3586, 3593, 3726, 3730, 3797, 3800, 4024, 4081, 4224, 4240, 4293, 4296], 'plasma': [13, 90, 109, 159, 178, 261, 338, 357, 407, 426, 1214, 1229, 1321, 1491, 1833, 1844, 2069, 2103, 2255, 2284, 2292, 2801, 2812, 2937, 3030, 3049, 3260, 3362, 3539, 3601, 3866, 3877, 3932, 4176, 4289], 'lipoprotein': [14, 262, 1892, 3188, 3221], 'metabolism,': [15, 263, 509, 4310], 'all': [16, 264, 511, 936], 'of': [17, 27, 238, 265, 275, 486, 512, 520, 571, 602, 672, 679, 805, 830, 925, 928, 956, 962, 1072, 1186, 1472, 1479, 1489, 1527, 1607, 1617, 1665, 1769, 1776, 1799, 2013, 2016, 2075, 2250, 2339, 2342, 2633, 2656, 2667, 2713, 2726, 2831, 2931, 2967, 2978, 3022, 3029, 3040, 3048, 3070, 3074, 3120, 3129, 3164, 3169, 3178, 3187, 3305, 3319, 3361, 3455, 3600, 3611, 3712, 3865, 3876, 3887, 3900, 3969, 3973, 4020, 4027, 4152, 4175, 4231, 4313], 'which': [18, 266], 'may': [19, 267, 514, 2869], 'well': [20, 268, 1200, 1681, 3631, 4317], 'have': [21, 224, 269, 472, 497, 714, 771, 865, 904, 1065, 2870, 2890, 3114, 3531, 4163], 'an': [22, 225, 243, 270, 473, 491, 596, 995, 1109, 1226, 1600, 1614, 1696, 2872, 3208, 3214, 3452, 3543, 3937, 4319], 'impact': [23, 271, 1185, 2033, 2873, 3864, 4174], 'on': [24, 227, 272, 475, 1189, 1246, 1293, 1450, 1482, 1593, 1906, 2001, 2034, 2137, 2254, 2398, 2461, 2613, 2635, 2659, 2716, 2874, 2940, 2985, 3201, 3206, 3839, 3869, 3958, 3975, 4089, 4179, 4233, 4259, 4308], 'the': [25, 31, 48, 273, 279, 296, 518, 565, 569, 600, 677, 763, 819, 825, 901, 905, 923, 926, 929, 960, 1148, 1184, 1196, 1470, 1495, 1533, 1574, 1585, 1594, 1604, 1608, 1618, 1641, 1654, 1663, 1666, 1670, 1675, 1683, 1823, 1826, 1872, 1883, 1959, 1963, 2014, 2251, 2296, 2325, 2340, 2618, 2631, 2670, 2729, 2783, 2795, 2817, 2842, 2878, 2887, 2941, 3037, 3118, 3167, 3179, 3185, 3198, 3323, 3447, 3581, 3609, 3721, 3859, 3885, 3909, 3943, 3946, 3970, 4007, 4022, 4025, 4069, 4082, 4150, 4170, 4229, 4238, 4301, 4311], 'development': [26, 229, 274, 477, 519, 1194, 4168], 'atherosclerosis.': [28, 247, 276, 495, 521, 4324], 'To': [29, 277, 1957, 2026, 2629], 'investigate': [30, 278, 1183, 1958, 2027], 'relationship': [32, 280], 'between': [33, 281, 1751], 'sphingolipid': [34, 52, 282, 300, 665, 2036, 2128, 2356, 2452], 'metabolism': [35, 283, 601, 1191], 'atherosclerosis,': [37, 285], 'we': [38, 286, 1179, 1970, 2637, 2663, 2721, 2780, 2885, 3842, 3857, 4241], 'utilized': [39, 287, 1180, 1971, 2607, 4220], 'myriocin': [40, 60, 73, 153, 288, 308, 321, 401, 1033, 1181, 1208, 1667, 1800, 1855, 1900, 1968, 1988, 2029, 2051, 2064, 2131, 2252, 2277, 2310, 2368, 2375, 2392, 2455, 2576, 2611, 2634, 2657, 2714, 2772, 2788, 2832, 2932, 2962, 3041, 3053, 3153, 3618, 3894, 4158, 4189, 4232, 4254, 4286], 'to': [41, 289, 517, 997, 1064, 1070, 1182, 1573, 1646, 1973, 2609, 2846, 3036, 3117, 3151, 3213, 3457, 3624, 3678, 3719, 3731, 3930, 3953, 3955, 4014, 4085, 4154, 4166, 4227], 'inhibit': [42, 290], 'mouse': [43, 291, 1111, 1490, 2102, 2639, 2936, 4171], 'serine': [44, 292, 531], 'palmitoyl-CoA': [45, 293, 523, 532], 'transferase': [46, 294, 524], '(SPT),': [47, 295], 'key': [49, 297, 3081], 'enzyme': [50, 298, 567, 3082], 'for': [51, 66, 246, 299, 314, 494, 707, 1154, 1287, 1324, 1810, 2271, 2782, 3083, 3547, 3608, 3660, 3884, 3963, 4323], 'biosynthesis.': [53, 301], 'We': [54, 302, 1205, 1985, 2047, 2352, 2606, 2644, 2674, 3530, 4219], 'injected': [55, 303, 1282, 1531, 1795], '8-week-old': [56, 304, 1777], 'apoE-deficient': [57, 305, 1197, 3160], 'mice': [58, 306, 1245, 1261, 1671, 1780, 1816, 1905, 2121, 2136, 2259, 2397, 2460, 2588, 2793, 2984, 3616, 3852, 3892, 4075, 4201], 'with': [59, 307, 818, 1494, 1513, 1556, 1603, 1653, 1796, 1888, 1965, 2262, 2274, 2321, 2703, 2761, 3063, 3259, 3904], '(0.3': [61, 309, 1272, 1801], 'mg/kg/every': [62, 310], 'other': [63, 311, 608, 1285, 1808, 2035, 2355, 2891, 4008], 'day,': [64, 312], 'intraperitoneal)': [65, 313], '60': [67, 315], 'days.': [68, 316], 'On': [69, 148, 317, 396, 3942, 4006], 'chow': [71, 319, 1248, 1908, 2139, 2661, 2942], 'diet,': [72, 152, 320, 400, 2662, 2720], 'treatment': [74, 154, 245, 322, 402, 493, 1668, 2030, 2052, 2065, 2369, 2577, 3054, 3154, 4159, 4190, 4302, 4322], 'caused': [75, 155, 323, 403, 1210, 1225, 1234, 2794, 3155], 'significant': [77, 87, 106, 124, 130, 191, 197, 325, 335, 354, 372, 378, 439, 445, 1999, 2011, 2337, 2822, 2965, 3303], 'decrease': [78, 131, 198, 326, 379, 446, 1212, 1236, 3119, 3163, 3599, 3875], '(50%)': [79, 327], 'liver': [81, 329, 625, 919, 1824], 'SPT': [82, 232, 239, 330, 480, 487, 594, 619, 673, 806, 831, 963, 1030, 1155, 1187, 1820, 4282, 4314], 'activity': [83, 240, 331, 488, 620, 671, 807, 964, 1156, 1821, 3086, 3131, 4315], '(p': [84, 101, 113, 145, 170, 182, 212, 332, 349, 361, 393, 418, 430, 460, 1840, 1851, 1879, 2306, 2679, 2692, 2737, 2750], '<': [85, 102, 114, 146, 171, 183, 213, 333, 350, 362, 394, 419, 431, 461, 1841, 1852, 1880, 1922, 1929, 1940, 1946, 2165, 2172, 2179, 2186, 2193, 2200, 2207, 2216, 2223, 2230, 2236, 2307, 2415, 2422, 2433, 2439, 2490, 2499, 2506, 2513, 2520, 2527, 2534, 2541, 2548, 2555, 2561, 2680, 2693, 2738, 2751], '0.001),': [86, 334], 'decreases': [88, 157, 336, 405, 2799, 2823, 4288], 'sphingomyelin,': [91, 160, 339, 408], 'ceramide,': [92, 161, 340, 409], 'sphingosine-1-phosphate': [94, 163, 342, 411, 1222, 1503], 'levels': [95, 111, 121, 164, 180, 343, 359, 369, 412, 428, 1835, 1846, 1862, 1995, 2015, 2071, 2286, 2294, 2316, 2341, 2939, 3051, 3541, 3603, 3868, 3879, 4178, 4295], '(54,': [96, 344], '32,': [97, 345], '73%,': [99, 347], 'respectively)': [100, 169, 348, 417, 2305], '0.0001),': [103, 172, 351, 420], 'increase': [107, 176, 355, 424, 1227, 3168, 3215], 'phosphatidylcholine': [110, 179, 358, 427, 1230], '(91%)': [112, 360, 1850], '0.0001).': [115, 184, 363, 432], 'Plasma': [116, 364, 1355], 'total': [117, 365, 1398, 1858], 'cholesterol': [118, 186, 221, 366, 434, 469, 684, 1253, 1305, 1859, 1981, 2002, 2267, 2313, 2384, 2875, 2882, 2938, 2969, 2988, 3031, 4309], 'triglyceride': [120, 188, 368, 436, 1338, 1861, 2315], 'demonstrated': [122, 189, 370, 437, 2781], 'no': [123, 190, 371, 438, 1998, 2010, 2336, 4257, 4304], 'changes,': [125, 192, 373, 440], 'but': [126, 193, 374, 441, 604, 1996, 2072, 2580, 3856, 4193], 'there': [127, 194, 375, 442, 2008, 2334], 'was': [128, 195, 376, 443, 1281, 1322, 1357, 1392, 1405, 1492, 1542, 1591, 1771, 1875, 1894, 2045, 2377, 2386, 2734, 2844, 3044, 3061, 4012], 'atherosclerotic': [133, 200, 228, 381, 448, 476, 1238, 2825, 2979, 3157, 3250, 3846], 'lesion': [134, 201, 382, 449, 2651, 2687, 2700, 2745, 2758], 'area': [135, 202, 383, 450, 1626, 1638], '(42%': [136, 384], 'root': [138, 205, 386, 453, 1693], '36%': [140, 388, 2691], 'en': [142, 209, 390, 457, 1697], 'face': [143, 210, 391, 458, 1698], 'assays)': [144, 211, 392, 459], '0.01).': [147, 214, 395, 462], 'high': [150, 398, 542, 683, 1250, 1252, 1302, 1304, 2264, 2266, 2381, 2383, 2400, 2463, 2879, 2881, 2944, 2987, 3317], 'fat': [151, 399, 1309, 2401, 2464, 2945], 'marked': [156, 175, 404, 423], '(59,': [165, 413], '66,': [166, 414], '81%,': [168, 416], '(100%)': [181, 429], 'Total': [185, 433, 1334, 2312], '(39%': [203, 451], '37%': [207, 455, 2749], 'These': [215, 463, 2768], 'results': [216, 464, 2327, 2769], 'indicate': [217, 465, 766, 2770], 'that,': [218, 466], 'apart': [219, 467], 'from': [220, 468, 1108, 1264, 1397, 1544, 1640, 3248, 3308], 'levels,': [222, 470, 1224, 1232, 2037, 2257, 2357, 2814, 2972, 3032], 'sphingolipids': [223, 471, 572], 'effect': [226, 474, 2000, 2253, 2376, 2612, 2632, 3112, 4230, 4258, 4307], 'that': [231, 479, 593, 767, 824, 1071, 1139, 1150, 1207, 1871, 1891, 1987, 2007, 2049, 2063, 2333, 2359, 2575, 2771, 2786, 2960, 3023, 3068, 3322, 3446, 3538, 3654, 3673, 4068, 4188, 4251], 'has': [233, 481, 589, 613, 1034, 2031, 3315, 3325, 3444, 3950, 4256, 4297, 4303], 'proatherogenic': [234, 482], 'properties.': [235, 483, 2776, 4299], 'Thus,': [236, 484, 4149], 'inhibition': [237, 485, 1188, 4283, 4312], 'could': [241, 489, 4316], 'be': [242, 490, 515, 1106, 1869, 3034, 3176, 3605, 3682, 3732, 3881, 4015, 4066, 4318], 'alternative': [244, 492, 4321], 'many': [498, 3968], 'biological': [499], 'functions,': [500], 'including': [501, 2018, 2038, 2344], 'lipid': [508, 609, 1190, 1332, 1897, 1960, 2256, 2389], 'these': [513], 'related': [516], 'Serine': [522], '(SPT)': [525], '1The': [526], 'abbreviations': [527], 'used': [528, 990, 3659], 'are:': [529], 'SPT,': [530, 709, 3075], 'transferase;': [533], 'Cer,': [534, 2039, 2053, 2076, 2360, 2803, 3320, 4291], 'ceramide;': [535], 'FPLC,': [536], 'fast': [537, 1325], 'protein': [538, 820, 1326], 'liquid': [539, 1327, 1536], 'chromatography;': [540], 'HDL,': [541], 'density': [543, 554], 'lipoprotein;': [544, 555], 'KO,': [545], 'gene': [546, 769], 'knock-out;': [547], 'LCB,': [548], 'long': [549, 590], 'chain': [550], 'base;': [551], 'LDL,': [552], 'low': [553], 'PC,': [556], 'phosphatidylcholine;': [557], 'SM,': [558, 1978, 2802, 4290], 'sphingomyelin;': [559], 'S1P,': [560, 2042, 2079, 2804, 4292], 'sphingosine-1-phosphat;': [561], 'Sph,': [562, 2040, 2054, 2077, 2361], 'sphingosine.': [563], 'is': [564, 621, 667, 674, 986, 2573, 3147, 3204, 3252, 3312, 3451, 3629, 3902, 3908, 3926, 3936, 4076, 4092, 4186], 'rate-limiting': [566], 'biosynthesis': [570], '(1Merrill': [573], 'A.H.': [574, 631, 646, 967], 'Jones': [575], 'D.D.': [576], 'Biochim.': [577, 3914], 'Biophys.': [578, 634, 654, 1085, 3915], 'Acta.': [579, 3916], '1990;': [580, 3405], '1044:': [581], '1-12Crossref': [582], 'PubMed': [583, 638, 660, 701, 732, 757, 798, 852, 879, 894, 948, 981, 1021, 1057, 1091, 1131, 1171, 1385, 1431, 1726, 1744, 2601, 2905, 2923, 3014, 3106, 3141, 3241, 3296, 3351, 3389, 3411, 3478, 3501, 3525, 3574, 3647, 3706, 3752, 3789, 3833, 3920, 4001, 4059, 4118, 4144, 4214, 4275], 'Scopus': [584, 639, 661, 733, 758, 799, 853, 880, 895, 949, 1022, 1058, 1092, 1132, 1172, 1386, 1432, 1727, 1745, 2602, 2864, 2906, 2924, 3015, 3107, 3142, 3242, 3274, 3297, 3352, 3390, 3412, 3479, 3502, 3526, 3575, 3648, 3707, 3790, 3834, 3921, 4002, 4060, 4119, 4145, 4215, 4276], '(412)': [585], 'Google': [586, 641, 663, 702, 735, 760, 801, 855, 882, 897, 951, 982, 1024, 1060, 1094, 1134, 1174, 1388, 1434, 1729, 1747, 2604, 2866, 2908, 2926, 3017, 3109, 3144, 3244, 3276, 3299, 3354, 3392, 3414, 3481, 3504, 3528, 3577, 3650, 3709, 3753, 3792, 3836, 3923, 4004, 4062, 4121, 4147, 4217, 4278], 'Scholar).': [587, 703, 802, 856, 898, 952, 983, 1025, 1095, 1135, 1175, 1389, 1435, 1748, 2605, 2927, 3018, 3110, 3145, 3245, 3300, 3355, 3440, 3529, 3651, 3710, 3754, 3837, 3924, 4005, 4063, 4148, 4218, 4279], 'It': [588, 1867, 2572, 4064, 4185], 'been': [591, 615, 715, 867, 1035, 3115, 3326, 3951], 'known': [592, 1201, 1605, 3632], 'plays': [595], 'sphingolipids,': [603], 'its': [605], 'metabolisms': [610], 'atherosclerosis': [612, 1193, 1202, 3612, 3870, 3888, 4167, 4180], 'not': [614, 1864, 2024, 2066, 2318, 2350, 2581, 2622, 2627, 2934, 4194, 4243, 4248], 'unequivocally': [616], 'determined.': [617], 'When': [618], 'increased': [622, 1849, 1877, 1993, 2301, 3366], 'rat': [624], '(2Williams': [626], 'R.D.': [627, 687, 971], 'Wang': [628, 647, 3742], 'E.': [629, 648, 3983, 4100], 'Merrill': [630], 'Arch.': [632], 'Biochem.': [633, 653, 890, 944, 1084, 3101, 3136, 4139], '1984;': [635, 657], '228:': [636], '282-291Crossref': [637], '(158)': [640], 'Scholar)': [642, 1061, 2867, 3578, 3793], 'lung': [644], '(3Merrill': [645], 'Stevens': [649], 'J.': [650, 692, 727, 889, 943, 972, 1015, 1051, 1416, 1425, 3102, 3137, 3226, 3235, 3290, 3336, 3345, 3383, 3403, 3463, 3472, 3495, 3514, 3690, 3739, 3747, 3773, 3817, 4055, 4128, 4140], 'Brumley': [651], 'G.W.': [652, 3098], 'Res.': [655, 694, 974, 1086, 3702, 3785, 3829], 'Commun.': [656, 1087], '119:': [658], '995-1000Crossref': [659], '(11)': [662], 'Scholar),': [664, 761], 'formation': [666], 'likewise': [668], 'increased.': [669], 'The': [670, 803, 953, 1265, 1290, 1621, 1633, 2087, 2096, 2113, 3019, 3162, 3356, 3598, 3863, 3874, 4173], 'heightened': [675], 'aortas': [678, 1679, 1685, 2640, 2671, 2730], 'rabbits': [680], 'fed': [681], 'diet': [685, 1306, 2270, 2385, 2989], '(4Williams': [686], 'Sgrutas': [688], 'D.S.': [689], 'Zaatari': [690], 'G.S.': [691], 'Lipid': [693, 973, 1317], '1986;': [695], '27:': [696], '763-770Abstract': [697], 'Full': [698, 978, 1128, 1168, 3408, 3520, 3522], 'Text': [699, 979, 1129, 1169, 3409, 3521, 3523], 'PDF': [700, 980, 1130, 1170, 3410, 3524], 'Two': [704, 1774], 'candidate': [705], 'cDNAs': [706], 'yeast': [708, 810], 'termed': [710], 'LCB1': [711, 814, 860, 1102, 1140], 'LCB2,': [713, 816, 1104], 'cloned': [716, 868], '(5Buede': [717], 'R.': [718, 1012, 1048, 2856, 3005, 3686, 3694, 3769, 3777, 3813, 3821], 'Rinker-Schaffer': [719], 'C.': [720, 1414, 1710, 3640], 'Pinto': [721], 'W.J.': [722], 'Lester': [723, 743, 784, 838, 871], 'R.L.': [724, 744, 785, 839, 872, 2993, 4040], 'Dickson': [725, 745, 786, 840, 873], 'R.C.': [726, 746, 787, 841, 874], 'Bacteriol.': [728], '1991;': [729], '173:': [730], '4325-4332Crossref': [731], '(160)': [734], 'Scholar,': [736, 883, 1730, 2909, 3277, 3393, 3415, 3482, 3505, 4122], '6Nagiec': [737], 'M.M.': [738, 779, 833, 870], 'Baltisberger': [739, 780, 834], 'J.A.': [740, 781, 835], 'Wells': [741, 782, 836], 'G.B.': [742, 783, 837], 'Proc.': [747, 788, 842], 'Natl.': [748, 789, 843], 'Acad.': [749, 790, 844, 3269], 'Sci.': [750, 791, 845, 3270], 'U.': [751, 792, 846], 'S.': [752, 793, 847, 1006, 1010, 1042, 1046, 1079, 1708, 3417], 'A.': [753, 794, 848, 1716, 3430, 3989, 4106, 4134], '1994;': [754, 795, 849, 1018, 1054], '91:': [755, 796, 850], '7899-7902Crossref': [756, 797, 851], '(192)': [759, 800, 854], 'translated': [764], 'sequences': [765], 'their': [768, 1647], 'products': [770], '21%': [773], 'amino': [774], 'acid': [775], 'sequence': [776], 'identity': [777], '(6Nagiec': [778, 832], 'lack': [804], 'strain': [811], 'defective': [812], 'or': [815, 1278, 1300, 1803, 1966, 2275, 2943, 3666, 3933, 3939, 4305], 'together': [817], 'similarity': [821], 'data,': [822], 'suggest': [823], 'two': [826, 902, 930, 1100, 2089, 2829], 'genes': [827], 'encode': [828], 'subunits': [829], 'Mouse': [857], 'human': [859, 3249, 3310, 3897, 3959], 'LCB2': [862, 957, 1142], 'cDNA': [863], 'homologues': [864], 'also': [866, 1406, 2073, 2092, 2353, 2645, 2675, 2722, 4181], '(7Nagiec': [869], 'Gene.': [875], '1996;': [876, 3103, 3238, 3348, 3475, 3517], '177:': [877], '237-241Crossref': [878], '(71)': [881], '8Weiss': [884], 'B.': [885, 939], 'Stoffel': [886, 940], 'W.': [887, 941], 'Eur.': [888, 942], '1997;': [891, 945], '249:': [892, 946], '239-247Crossref': [893, 947], '(161)': [896, 950], 'In': [899, 1176, 2777, 2951, 3441, 3755, 3896, 4280], 'mouse,': [900, 1198], 'mRNAs': [903], 'same': [906, 2326], 'tissue': [907, 954], 'distribution': [908, 955, 961, 1961], '(lung,': [909], 'kidney': [910], '>': [911, 913, 916, 918, 920], 'brain': [912], 'cartilage,': [914], 'skin': [915], 'heart': [917, 3549], 'muscle),': [921], 'ratio': [924, 1874, 2298], 'amounts': [927, 1606], 'transcripts': [931], 'remains': [932], 'approximately': [933], 'constant': [934], 'tissues': [937], '(8Weiss': [938], 'mRNA': [958], 'parallels': [959], '(9Merill': [965], 'Jr.,': [966], 'Nixon': [968], 'D.W.': [969], 'William': [970], '1985;': [975, 3271], '26:': [976], '617-622Abstract': [977], 'Isaria': [984], 'sinclairii': [985], 'fungus': [988], 'traditionally': [989], 'Chinese': [992], 'medicine': [993], 'effort': [996], 'attain': [998], 'eternal': [999], 'youth': [1000], '(10Fujita': [1001, 1037], 'T.': [1002, 1008, 1038, 1044, 1081, 1083, 2852, 3279, 3372, 3484, 3979, 4096], 'Inoue': [1003, 1039], 'K.': [1004, 1040, 1712, 3981, 3987, 4098, 4104, 4126], 'Yamamoto': [1005, 1041], 'Ikumoto': [1007, 1043], 'Sasaki': [1009, 1045], 'Toyama': [1011, 1047], 'Chiba': [1013, 1049], 'D.': [1014, 1050, 1732, 3741], 'Antibiot.': [1016, 1052], '(Tokyo).': [1017, 1053], '47:': [1019, 1055], '208-215Crossref': [1020, 1056], '(517)': [1023, 1059], 'From': [1026], 'it,': [1027], 'specific': [1029, 3127], 'inhibitor': [1031, 3073, 3128], 'named': [1032], 'isolated': [1036], 'proven': [1063], 'molecular': [1067], 'structure': [1068], 'similar': [1069], 'sphingosine': [1073, 1219, 1441, 1506], '(11Miyake': [1074], 'Y.': [1075, 1077, 1420, 3268, 3743], 'Kozutsumi': [1076], 'Nakamura': [1078], 'Fujita': [1080], 'Kawasaki': [1082], '1995;': [1088, 2861, 3138], '211:': [1089], '396-403Crossref': [1090], '(473)': [1093], 'Using': [1096], 'myriocin-based': [1097], 'affinity': [1098], 'chromatography,': [1099], 'proteins,': [1101], 'can': [1105, 3681], 'purified': [1107], 'interleukin-2-dependent': [1110], 'cytotoxic': [1112], 'T': [1113, 2614, 4234, 4260], 'line': [1115], '(CTLL-2)': [1116], '(12Chen': [1117, 1157], 'J.K.': [1118, 1158], 'Lane': [1119, 1159], 'W.S.': [1120, 1160, 2999, 4042], 'Schreiber': [1121, 1161], 'S.L.': [1122, 1162, 3224, 3281, 3334, 3374, 3461, 3486, 3507], 'Chem.': [1123, 1163, 2859, 3516], 'Biol.': [1124, 1164, 1381, 1740, 3515, 3570, 3997, 4114], '1999;': [1125, 1165, 1428, 3436], '6:': [1126, 1166], '221-235Abstract': [1127, 1167], '(96)': [1133, 1173], 'This': [1136, 3059, 3111], 'result': [1137, 3060, 3582], 'indicates': [1138], 'are': [1143, 1152, 1760, 2091, 2104, 2122, 2828, 3364, 3542, 3658], 'myriocin-binding': [1144], 'proteins': [1145], 'confirms': [1147], 'fact': [1149], 'they': [1151], 'responsible': [1153], 'this': [1177, 2778, 3621, 3964], 'study,': [1178], 'animal': [1203, 3369], 'model.': [1204, 1661, 4172], 'found': [1206, 1986, 2048, 2623, 2664, 2676, 2723, 3672, 3858, 4013], 'administration': [1209, 1901, 2132, 2323, 2393, 2456, 2658, 2715, 2789, 2963, 3069, 4255], 'sphingomyelin': [1215, 1356], '(SM),': [1216], 'ceramide': [1217, 1446], '(Cer),': [1218], '(Sph),': [1220], '(S1P)': [1223], '(PC)': [1231], 'lesions': [1239, 2668, 2727, 2980, 3158, 3251, 3311, 3847], 'apoE': [1241, 1259, 1778, 1903, 2100, 2119, 2134, 2395, 2458, 2791, 2982, 3614, 3850, 3890, 4073], 'knock-out': [1242], '(apoE': [1243], 'KO)': [1244], 'both': [1247, 3365, 4021], 'fat,': [1251, 1303, 2265, 2382, 2880], 'diets.': [1254], 'Animals': [1255], 'Myriocin': [1257, 1271], 'Treatment—Eight-week-old': [1258], 'KO': [1260, 1779, 1904, 2101, 2120, 2135, 2396, 2459, 2792, 2983, 3615, 3851, 3891, 4074], 'were': [1262, 1292, 1343, 1448, 1530, 1580, 1628, 1643, 1672, 1686, 1700, 1753, 1781, 1794, 1836, 1847, 1863, 2009, 2057, 2260, 2287, 2299, 2317, 2335, 2364], 'purchased': [1263], 'Jackson': [1266], 'Laboratory': [1267], '(Bar': [1268], 'Harbor,': [1269], 'ME).': [1270], 'mg/kg)': [1273, 1802, 2583, 4196], '(Biomol': [1274], 'Research': [1275], 'Laboratories': [1276], 'Inc.)': [1277], 'phosphate-buffered': [1279, 1804], 'saline': [1280], 'intraperitoneally': [1283], 'every': [1284, 1807], 'day': [1286, 1809], '8': [1288, 1811, 2272], 'weeks.': [1289, 1812], 'animals': [1291, 1793], 'Purina': [1294], 'Rodent': [1295], 'Chow': [1296], '(catalog': [1297], 'number': [1298], '5001)': [1299], '(20%': [1307], 'milk': [1308], '0.15%': [1311], 'cholesterol;': [1312], 'Harlan': [1313], 'Teklad,': [1314], 'Madison,': [1315], 'WI).': [1316], 'Lipoprotein': [1319], 'Measurements—Fasting': [1320], 'collected': [1323, 1581], 'chromatography': [1328], '(FPLC)': [1329], 'separation': [1330], 'measurement.': [1333], 'cholesterol,': [1335], 'phospholipids': [1336], 'plasma,': [1340, 3898], 'lipoproteins': [1342, 1964, 1975, 3203], 'assayed': [1344], 'by': [1345, 1394, 1438, 1598, 1755, 3087, 3207, 3328, 3734, 3794, 4157, 4285], 'enzymatic': [1346], 'methods': [1347, 2830, 3039], '(Wako': [1348], 'Pure': [1349], 'Chemical': [1350], 'Industries': [1351], 'Ltd.,': [1352], 'Osaka,': [1353], 'Japan).': [1354], 'measured': [1358, 1977, 2354, 2646], 'as': [1359, 1408, 1680, 1682, 1702, 1762, 1886, 2889, 3150, 3257, 3929], 'described': [1360, 1409, 1703], 'previously': [1361, 1410, 1704, 3532], '(13Jiang': [1362, 3551], 'X.C.': [1363, 1412, 1706, 3289, 3382, 3494, 3552], 'Paultre': [1364, 3553], 'F.': [1365, 3554, 3913, 3993, 4110, 4138], 'Pearson': [1366, 3400, 3555], 'T.A.': [1367, 3401, 3556], 'Reed': [1368, 3557], 'R.G.': [1369, 3096, 3558], 'Francis': [1370, 3559], 'C.K.': [1371, 3560], 'Lin': [1372, 1417, 1713, 3561], 'M.': [1373, 1418, 1714, 2854, 3395, 3424, 3562, 3700, 3745, 3783, 3827, 3991, 4108, 4132, 4136], 'Berglund': [1374, 3563], 'L.': [1375, 3564, 3688, 3771, 3815], 'Tall': [1376, 1423, 1719, 3286, 3379, 3491, 3565], 'A.R.': [1377, 1424, 1720, 3287, 3380, 3492, 3566], 'Arterioscler.': [1378, 1737, 3567, 3994, 4111], 'Thromb.': [1379, 1738, 3568, 3995, 4112], 'Vasc.': [1380, 1739, 3569, 3996, 4113], '2000;': [1382, 3571, 3703, 3786, 3830, 4141], '20:': [1383, 3572], '2614-2618Crossref': [1384, 3573], '(326)': [1387, 3576], 'PC': [1390, 1845, 1994, 2293, 2813, 3050, 3084, 3170], 'concentration': [1391, 3450, 4071], 'obtained': [1393], 'subtracting': [1395], 'SM': [1396, 1834, 1991, 2070, 2285, 2971, 3165, 3189, 3195, 3256, 3363, 3449, 3540], 'phospholipid': [1399], 'concentration.': [1400, 1632], 'Apolipoprotein': [1401], 'analysis': [1402, 1590], 'using': [1403, 1584, 1657], 'SDS-PAGE': [1404, 2005, 2331], 'done': [1407], '(14Jiang': [1411], 'Bruce': [1413], 'Mar': [1415], 'Ji': [1419], 'Francone': [1421], 'O.L.': [1422], 'Clin.': [1426, 3236, 3291, 3346, 3384, 3473, 3496], 'Investig.': [1427, 3237, 3292, 3347, 3385, 3474, 3497], '103:': [1429], '907-914Crossref': [1430], '(327)': [1433], 'Sphingolipid': [1436], 'Analysis': [1437], 'Mass': [1439], 'Spectrometry—Plasma': [1440], 'bases,': [1442], 'sphingoid': [1443], 'base-1-phosphates,': [1444], 'species': [1447], 'performed': [1449, 1701], 'Thermo': [1452], 'Finnigan': [1453], 'TSQ': [1454], '7000': [1455, 1535], 'triple': [1456], 'quadrupole': [1457], 'mass': [1458, 2043], 'spectrometer': [1459], 'operating': [1460], 'multiple': [1463], 'reaction': [1464], 'monitoring,': [1465], 'positive': [1466], 'ionization': [1467], 'mode': [1468], 'at': [1469, 3663], 'Department': [1471], 'Biochemistry': [1473], 'Molecular': [1475], 'Biology,': [1476], 'Medical': [1477], 'University': [1478], 'South': [1480], 'Carolina,': [1481], 'fee-for-service': [1484], 'basis.': [1485], 'Briefly,': [1486], '250': [1487], 'μl': [1488, 1526, 1798], 'fortified': [1493], 'internal': [1496, 1578, 1619, 1649], 'standards': [1497, 1579, 1612, 1650], '(IC17': [1498], 'base': [1499], 'd-erythro-sphingosine': [1500], '(17C-Sph),': [1501], 'C17': [1502], '(17C-S1P),': [1504], 'N-palmitoyl-d-erythro-C13': [1505], '(13C-Cer),': [1507], 'heptadecanoyl-d-erythro-sphingosine': [1509], '(C17-Cer))': [1510], 'extracted': [1512, 3247, 3307], 'ethyl': [1514], 'acetate/iso-propanol/water': [1515], '(60:30:10)': [1516], '(v/v)': [1517], 'solvent': [1518], 'system.': [1519, 1570, 1588], 'After': [1520, 2653, 2710], 'evaporation': [1521], 'reconstitution': [1523], '100': [1525, 1797, 3437], 'methanol,': [1528], 'samples': [1529, 1642], 'onto': [1532], 'Surveyor/TSQ': [1534], 'chromatography/mass': [1537], 'spectrometry': [1538, 2044], 'system,': [1539], 'gradient': [1541], 'eluted': [1543], 'BDS': [1546], 'Hypersil': [1547], 'C8,': [1548], '150': [1549], '×': [1550], '3.2-mm,': [1551], '3-μm': [1552], 'particle': [1553], 'size': [1554], 'column': [1555], '1': [1558], 'mm': [1559, 1564], 'methanolic': [1560], 'ammonium': [1561, 1566], 'formate,': [1562], '2': [1563, 1789, 2654, 2711], 'aqueous': [1565], 'formate': [1567], 'mobile': [1568], 'phase': [1569], 'Peaks': [1571], 'corresponding': [1572], 'target': [1575, 1609, 1622, 1634], 'analytes': [1576], 'processed': [1583], 'Xcalibur': [1586], 'software': [1587], 'Quantitative': [1589], 'based': [1592], 'calibration': [1595, 1655], 'curves': [1596, 1656], 'generated': [1597], 'spiking': [1599], 'artificial': [1601], 'matrix': [1602], 'analyte': [1610, 1631], 'synthetic': [1611], 'equal': [1615], 'amount': [1616, 4083], 'standards.': [1620], 'analyte/internal': [1623, 1635], 'standard': [1624, 1636], 'peak': [1625, 1637], 'ratios': [1627, 1639], 'plotted': [1629], 'against': [1630], 'similarly': [1644], 'normalized': [1645], 'respective': [1648], 'compared': [1652, 1887, 2702, 2760, 3258], 'linear': [1659], 'regression': [1660], 'Atherosclerosis—At': [1662], 'end': [1664], 'period,': [1669], 'sacrificed,': [1673], 'hearts': [1676], 'proximal': [1678, 2647, 2685, 2743], 'whole': [1684, 2649, 2698, 2756], 'removed,': [1687], 'dissected,': [1688], 'photographed.': [1690], 'An': [1691], 'aorta': [1692], 'assay': [1694, 1699], '(15Jiang': [1705], 'Qin': [1707], 'Qiao': [1709], 'Kawano': [1711], 'Skold': [1715], 'Xiao': [1717], 'X.': [1718], 'Nat.': [1721], 'Med.': [1722, 2858], '2001;': [1723, 3644, 3749], '7:': [1724], '847-852Crossref': [1725, 2863], '(233)': [1728], '16Teupser': [1731], 'Persky': [1733], 'A.D.': [1734], 'Breslow': [1735], 'J.L.': [1736], '2003;': [1741, 3998, 4056, 4115], '23:': [1742, 3999, 4116], '1907-1913Crossref': [1743], '(140)': [1746], 'Statistical': [1749], 'Analysis—Differences': [1750], 'groups': [1752, 1775], 'tested': [1754], "Student's": [1756], 't': [1757], 'test.': [1758], 'Data': [1759], 'presented': [1761], 'mean': [1763, 2684, 2697, 2742, 2755], '±': [1764, 1910, 1912, 1914, 1916, 1918, 1920, 1927, 1934, 1936, 1938, 2141, 2143, 2145, 2147, 2149, 2151, 2153, 2155, 2157, 2159, 2161, 2163, 2170, 2177, 2184, 2191, 2198, 2205, 2212, 2214, 2221, 2228, 2403, 2405, 2407, 2409, 2411, 2413, 2420, 2427, 2429, 2431, 2466, 2468, 2470, 2472, 2474, 2476, 2478, 2480, 2482, 2484, 2486, 2488, 2495, 2497, 2504, 2511, 2518, 2525, 2532, 2539, 2546, 2553], 'S.D.': [1765], 'A': [1766], 'p': [1767, 1945, 2235, 2438, 2560], 'value': [1768], '<0.05': [1770], 'considered': [1772], 'significant.': [1773], 'utilized.': [1782, 2046], 'Group': [1783], '1(n': [1784], '=': [1785, 1791, 1925, 1932, 1943, 1949, 2168, 2175, 2182, 2189, 2196, 2203, 2210, 2219, 2226, 2233, 2239, 2418, 2425, 2436, 2442, 2493, 2502, 2509, 2516, 2523, 2530, 2537, 2544, 2551, 2558, 2564], '7)': [1786, 1792], 'group': [1788, 1885], '(n': [1790], 'saline,': [1805], 'respectively,': [1806], 'As': [1813, 1828, 2279], 'expected,': [1814], 'myriocin-treated': [1815, 1884, 3849], 'had': [1817, 1997, 2871], '50%': [1818], 'less': [1819], 'than': [1825, 3853], 'controls.': [1827], 'shown': [1829, 2280, 2845, 3445, 3533, 3952], 'Table': [1831, 2282, 2450], 'I,': [1832], 'significantly': [1837, 1848, 1865, 1989, 2058, 2319], 'decreased': [1838, 1990, 2059, 2289, 2366], '(54%)': [1839], '0.001)': [1842], '0.0001)': [1853, 1881, 2308], 'after': [1854, 1899, 2050, 2130, 2309, 2367, 2391, 2454, 3052, 3617, 3893], 'administration,': [1856], 'whereas': [1857, 2291], 'changed.': [1866], 'should': [1868, 3843, 4065], 'emphasized': [1870], 'PC/SM': [1873, 2297, 2818], 'dramatically': [1876, 2288, 2300, 2365, 4287], '(317%)': [1878], 'control,': [1889], 'indicating': [1890, 2062, 3067, 3321], 'composition': [1893], 'changed.Table': [1895], 'IPlasma': [1896], 'measurement': [1898, 2129, 2390, 2453], 'dietSMPCCholTGPC/SMmg/dlmg/dlmg/dlmg/dlControl71': [1909], '8209': [1911], '23591': [1913], '7365': [1915], '172.9': [1917], '0.5Myriocin33': [1919], '3ap': [1921, 2178], '0.001,': [1923, 1930, 1941, 1947, 2416, 2423, 2434, 2440], 'n': [1924, 1931, 1942, 1948, 2167, 2174, 2181, 2188, 2195, 2202, 2209, 2218, 2225, 2232, 2238, 2417, 2424, 2435, 2441, 2492, 2501, 2508, 2515, 2522, 2529, 2536, 2543, 2550, 2557, 2563], '7.399': [1926], '59ap': [1928], '7.660': [1933], '10575': [1935], '1912.1': [1937], '0.2ap': [1939, 2432], '7.a': [1944, 2234, 2437, 2559], '7.': [1950, 2240, 2443, 2565], 'Open': [1951, 2241, 2444, 2566], 'table': [1952, 2242, 2445, 2567], 'new': [1955, 2245, 2448, 2570], 'tab': [1956, 2246, 2449, 2571], 'among': [1962], 'without': [1967, 2276], 'treatment,': [1969], 'FPLC': [1972, 2322], 'fractionize': [1974], 'PL,': [1979], 'each': [1983], 'fraction.': [1984], '(Fig.': [2003, 2328, 2672, 2705, 2731, 2763, 3861], '1).': [2004], 'revealed': [2006, 2332], 'changes': [2012, 2338], 'apolipoproteins,': [2017, 2343], 'apoB100,': [2019, 2345], 'apoB48,': [2020, 2346], 'apoA-I': [2022, 2348], '(data': [2023, 2349, 2626, 4247], 'shown).': [2025, 2351, 2628], 'whether': [2028, 3931], 'any': [2032, 2624, 4245], 'S1P': [2056, 2114, 2363, 3878, 3901, 3935, 3947, 4011, 4070, 4087, 4153, 4177], '(Table': [2060, 2110, 2125, 2370, 4079, 4160], 'II),': [2061, 4080], 'only': [2067], 'influences': [2068], 'those': [2074], 'three': [2080], 'second': [2082, 3633], 'messengers': [2083], 'transduction.': [2086], 'following': [2088], 'findings': [2090], 'worth': [2093], 'noting.': [2094], '1)': [2095, 2797], 'major': [2097, 3910], 'ceramides': [2098], 'Cer24:0,': [2105], 'Cer24:1,': [2106], 'Cer18:0,': [2107], 'C16:0': [2109], 'II).': [2111], '2)': [2112, 2808], 'Sph': [2116, 2806, 3121, 4294], 'concentrations': [2117, 3360], '∼200': [2123], 'nm': [2124, 4078, 4094, 4156], 'II).Table': [2126], 'IIPlasma': [2127], 'dietC18:1CerC14CerC16CerC18CerC20CerC24CerC24:1CerDHSphDHSph-1PSphS1PnmnmnmnmnmnmnmnmnmnmnmControl9': [2140], '210': [2142], '324': [2144], '287': [2146], '961': [2148], '82123': [2150], '2011461': [2152], '20927': [2154], '546': [2156], '12173': [2158], '21226': [2160], '50Myriocin2': [2162], '1ap': [2164, 2489, 2533], '0.01,': [2166, 2173, 2180, 2187, 2194, 2201, 2208, 2217, 2224, 2231, 2237, 2491, 2500, 2507, 2514, 2521, 2528, 2535, 2542, 2549, 2556, 2562], '7.12': [2169], '2ap': [2171, 2540], '7.11': [2176], '7.51': [2183], '8ap': [2185, 2222], '7.35': [2190], '9ap': [2192, 2229], '7.1321': [2197], '22ap': [2199], '7.854': [2204], '144ap': [2206], '7.30': [2211], '39': [2213], '5ap': [2215], '7.127': [2220], '7.58': [2227], 'For': [2247], 'further': [2248, 3872, 4183], 'evaluation': [2249], '2-month-old': [2258], 'challenged': [2261], '(Western': [2268], 'type)': [2269], 'weeks': [2273], 'treatment.': [2278, 3619, 3895], 'III,': [2283], '(59%),': [2290], '(100%': [2302], '380%,': [2304], 'administration.': [2311, 2840], 'changed,': [2320], 'producing': [2324], '2).': [2329], 'Again,': [2330], 'finding': [2358], 'IV).': [2371], 'Basically,': [2372], 'profound': [2374, 3046], 'observed': [2378], 'when': [2379], 'used.Table': [2387], 'IIIPlasma': [2388], 'dietSMPCCholTGPC/SMmg/dlmg/dlmg/dlmg/dlControl114': [2402], '11397': [2404], '931827': [2406], '30695': [2408], '193.5': [2410], '0.5Myriocin47': [2412], '14ap': [2414, 2505], '7.795': [2419], '97ap': [2421], '7.1807': [2426], '342107': [2428], '2716.9': [2430], 'IVPlasma': [2451], 'dietC18:1CerC14CerC16CerC18CerC20CerC24CerC24:1CerDHSphDHSph-1PSphS1PnmnmnmnmnmnmnmnmnmnmnmControl61': [2465], '222': [2467], '395': [2469], '19205': [2471], '32100': [2473], '55551': [2475], '9112423': [2477], '27729': [2479], '355': [2481], '12172': [2483], '21218': [2485], '55Myriocin9': [2487], '7.20': [2494, 2531], '212': [2496], '6ap': [2498], '7.36': [2503], '7.45': [2510], '11ap': [2512], '7.1708': [2517], '426ap': [2519], '7.1009': [2524], '134ap': [2526], '7.10': [2538], '7.114': [2545], '19ap': [2547, 2554], '7.42': [2552], 'reported': [2574, 4187], '(1': [2578, 4191], 'mg/kg': [2579, 4192, 4253], '0.3': [2582, 4195, 4252], 'reduces': [2584, 4197], 'T-lymphocyte': [2585, 4198], 'populations': [2586, 4199, 4262], '(17Johnson': [2589], 'V.J.': [2590, 2896, 2913, 4203, 4264], 'He': [2591, 2914, 4204, 4265], 'Q.': [2592, 2894, 2915, 4205, 4266], 'Osuchowski': [2593, 2897, 4206, 4267], 'M.F.': [2594, 2898, 2911, 4207, 4268], 'Sharma': [2595, 2899, 2916, 4208, 4269], 'R.P.': [2596, 2900, 2917, 3696, 3779, 3823, 4209, 4270], 'Toxicology.': [2597, 4210, 4271], '2004;': [2598, 2902, 2920, 3011, 4211, 4272], '201:': [2599, 4212, 4273], '67-75Crossref': [2600, 4213, 4274], '(20)': [2603], 'FAS': [2608], 'evaluate': [2610, 2630, 4228], 'counts': [2616, 4236], 'circulation': [2619], 'did': [2621, 2933, 4242], 'difference': [2625, 4246], 'atherogenesis,': [2636], 'dissected': [2638], 'photographed': [2642], 'them.': [2643], 'aortic': [2650, 2686, 2699, 2744, 2757], 'areas.': [2652], 'months': [2655, 2712], 'reduction': [2666, 2682, 2695, 2725, 2740, 2753, 2966, 2977, 3610, 3886, 4151], '3A).': [2673, 2732], '42%': [2678], '0.01)': [2681, 2694, 2739, 2752], 'areas': [2688, 2701, 2746, 2759], 'controls': [2704, 2762], '3,': [2706, 2764], 'B': [2707], 'C).': [2709], 'Western': [2718], 'type': [2719], 'There': [2733, 2827, 3043, 3146, 3925], '39%': [2736], 'D': [2765], 'E).': [2767], 'possesses': [2773], 'anti-atherosclerotic': [2775], 'study': [2779, 3024, 3537, 4034], 'first': [2784], 'time': [2785], 'intraperitoneal': [2787, 2836, 2929], 'following:': [2796], 'dramatic': [2798, 2809, 2976], 'levels;': [2807], 'increases': [2810], 'thus': [2815, 2973], 'increasing': [2816], 'ratio;': [2819], '3)': [2821], 'lesions.': [2826], 'delivery': [2833], 'vivo,': [2835, 3756], 'injection': [2837, 2930], 'oral': [2839, 2961], 'Because': [2841, 4300], 'latter': [2843], 'inflict': [2847], 'serious': [2848], 'gastrointestinal': [2849], 'toxicity': [2850], '(18Fugita': [2851], 'Yoneta': [2853], 'Hirose': [2855], 'Bioorg.': [2857], 'Lett.': [2860, 2919], '5:': [2862], '(97)': [2865], 'absorption': [2876], 'during': [2877], 'loading': [2883], 'experiment,': [2884], 'chose': [2886], 'former,': [2888], 'investigators': [2892], '(19He': [2893], 'Johnson': [2895, 2912], 'Mycopathologia.': [2901], '157:': [2903], '339-347Crossref': [2904], '(23)': [2907, 4216, 4277], '20Osuchowski': [2910], 'Toxicol.': [2918], '147:': [2921], '87-94Crossref': [2922], '(18)': [2925], 'Indeed,': [2928], 'change': [2935], 'diets': [2946], '(Tables': [2947, 3055, 3122], 'I': [2948, 3056], 'III).': [2950, 3058], 'most': [2953], 'recent': [2954, 4032], 'report,': [2955], 'Park': [2956], 'et': [2957, 3670], 'al.': [2958, 3671], 'showed': [2959], 'causes': [2964], 'plassma': [2968], 'causing': [2974], '(21Park': [2990], 'T.S.': [2991], 'Panek': [2992], 'Mueller': [2994], 'S.B.': [2995], 'Hanselman': [2996], 'J.C.': [2997], 'Rosebury': [2998], 'Robertson': [3000], 'A.W.': [3001], 'Kindt': [3002], 'E.K.': [3003], 'Homan': [3004], 'Karathanasis': [3006], 'S.K.': [3007], 'Rekhter': [3008], 'M.D.': [3009], 'Circulation.': [3010, 3435], '110:': [3012], '3465-3471Crossref': [3013], '(193)': [3016], 'different': [3020, 3038], 'outcome': [3021], 'ours,': [3026], 'terms': [3028], 'might': [3033, 3113, 3175, 3604, 3880, 4162], 'due': [3035, 3116], 'delivery.': [3042], 'induction': [3047], 'consistent': [3062], 'previous': [3065], 'report': [3066], 'l-cycloserine,': [3071], 'another': [3072, 3584, 3606, 3882], 'stimulated': [3076], 'CTP:choline-phosphate': [3077], 'cytidylyltransferase': [3078], '(CT;': [3079], 'biosynthesis)': [3085], '74%': [3088], '(22Mallampalli': [3089], 'R.K.': [3090], 'Mathur': [3091], 'S.N.': [3092], 'Warnock': [3093], 'L.J.': [3094], 'Salome': [3095], 'Hunninghake': [3097], 'Field': [3099], 'F.J.': [3100], '318:': [3104], '333-341Crossref': [3105], '(29)': [3108], 'II': [3123], 'IV),': [3125], 'CT': [3130], '(23Sohal': [3132], 'P.S.': [3133], 'Cornell': [3134], 'R.B.': [3135], '311:': [3139], '873-879Crossref': [3140], '(24)': [3143], 'some': [3148, 3927], 'question': [3149], 'why': [3152], 'fewer': [3156], 'mice.': [3161], 'contents': [3171], 'non-HDL': [3173], 'particles': [3174], 'one': [3177, 3944], 'mechanisms.': [3180], 'Substantial': [3181], 'evidence': [3182], 'now': [3183], 'supports': [3184], 'arterial': [3191, 3199, 3209], 'SMase': [3192], 'atherogenesis.': [3194], 'carried': [3196], 'into': [3197], 'wall': [3200, 3210], 'atherogenic': [3202, 3938], 'acted': [3205], 'SMase,': [3211, 3329], 'leading': [3212], 'Cer': [3217, 3602, 3628, 3657, 3674, 3735, 3867], 'content': [3218, 3318], 'promoting': [3220, 3667], 'aggregation': [3222, 3332, 3459], '(24Schissel': [3223, 3333, 3460], 'Tweedie-Hardman': [3225, 3335, 3462], 'Rapp': [3227, 3337, 3464], 'J.H.': [3228, 3338, 3465], 'Graham': [3229, 3339, 3466], 'G.': [3230, 3340, 3421, 3467], 'Williams': [3231, 3341, 3431, 3468, 3510], 'K.J.': [3232, 3342, 3432, 3469, 3511], 'Tabas': [3233, 3282, 3343, 3375, 3433, 3470, 3487, 3512], 'I.': [3234, 3283, 3344, 3376, 3434, 3471, 3488, 3513], '98:': [3239, 3349, 3476], '1455-1464Crossref': [3240, 3350, 3477], '(282)': [3243, 3353, 3480], 'LDL': [3246, 3261, 3306, 3324], 'highly': [3253], 'enriched': [3254], '(25Hoff': [3262], 'H.F.': [3263], 'Morton': [3264], 'R.E.': [3265], 'Ann.': [3266], 'N.': [3267, 3692, 3775, 3819, 4050, 4124], '545:': [3272], '183-194Crossref': [3273], '(65)': [3275], '26Jeong': [3278, 3483], 'Schissel': [3280, 3373, 3485], 'Pownall': [3284, 3377, 3489], 'H.J.': [3285, 3378, 3490], 'Jiang': [3288, 3381, 3493], '1998;': [3293, 3386, 3498], '101:': [3294, 3387, 3499], '905-912Crossref': [3295, 3388, 3500], '(122)': [3298, 3391, 3503], 'Moreover,': [3301], 'fraction': [3304], 'fresh': [3309], 'aggregated': [3313], 'modified': [3327], 'resulting': [3330], 'absolute': [3357], 'relative': [3359, 3448], 'atherosclerosis-susceptible': [3368], 'models': [3370], '(26Jeong': [3371], '27Miller': [3394], 'Mead': [3396], 'L.A.': [3397, 4048], 'Kwiterovich': [3398], 'P.O.': [3399], 'Am.': [3402, 3746, 4053], 'Cardiol.': [3404], '65:': [3406], '1-5Abstract': [3407], '(98)': [3413], '28Marathe': [3416], 'Tribble': [3418], 'D.L.': [3419], 'Kuriakose': [3420], 'La': [3422], 'Belle': [3423], 'Chu': [3425], 'B.M.': [3426], 'Gong': [3427], 'E.L.': [3428], 'Johns': [3429], '(abstr.):': [3438], 'I-695Google': [3439], 'vitro': [3442], 'manipulation': [3443], 'determinant': [3454], 'susceptibility': [3456], 'SMase-induced': [3458], '29Schissel': [3506], 'Schuchman': [3508], 'H.E.': [3509], '271:': [3518], '18431-18436Abstract': [3519], '(254)': [3527], 'case-control': [3536, 3589, 4033], 'independent': [3544], 'risk': [3545], 'factor': [3546], 'coronary': [3548, 4028], 'disease': [3550], 'confirmed': [3580], 'larger': [3585], 'more': [3587, 3845], 'homogenous': [3588], 'trial.': [3590], '2A.': [3591], 'Schlitt': [3592], 'X.-C.': [3594], 'Jiang,': [3595], 'unpublished': [3596], 'results.': [3597], 'mechanism': [3607, 3883], 'However,': [3620], 'hypothesis': [3622], 'seems': [3623], 'controvert': [3625], 'existing': [3626], 'reports.': [3627], 'messenger': [3634], 'involving': [3635], 'apoptosis': [3636], '(30Hannun': [3637], 'Y.A.': [3638], 'Luberto': [3639], 'Argraves': [3641], 'K.M.': [3642], 'Biochemistry.': [3643], '40:': [3645], '4893-4903Crossref': [3646], '(447)': [3649], 'Typically,': [3652], 'strategies': [3653], 'elevate': [3655], 'cellular': [3656], 'therapies': [3661], 'aimed': [3662], 'arresting': [3664], 'growth': [3665], 'apoptosis.': [3668], 'Charles': [3669], 'analogs,': [3675], 'applied': [3676], 'directly': [3677], 'damaged': [3679], 'arteries,': [3680], 'strongly': [3683], 'antiproliferative': [3684], '(31Charles': [3685, 3768, 3812], 'Sandirasegarane': [3687, 3770, 3814], 'Yun': [3689, 3738, 3772, 3816], 'Bourbon': [3691, 3774, 3818], 'Wilson': [3693, 3776, 3820], 'Rothstein': [3695, 3778, 3822], 'Levison': [3697, 3780, 3824], 'S.W.': [3698, 3781, 3825], 'Kester': [3699, 3744, 3782, 3826], 'Circ.': [3701, 3784, 3828], '87:': [3704, 3787, 3831], '282-288Crossref': [3705, 3788, 3832], '(54)': [3708, 3791, 3835], 'Proliferation': [3711], 'cultured': [3713], 'vascular': [3714, 3808], 'smooth': [3715, 3809], 'muscle': [3716, 3810], 'cells': [3717, 3811, 3961, 3977, 4091], 'appears': [3718], 'involve': [3720], 'extracellular': [3722], 'signal-regulated': [3723], 'kinase': [3724, 3728], '(ERK)': [3725], 'AKT': [3727, 3798], 'cascades': [3729], 'inhibited': [3733], '(32Bourbon': [3736], 'N.A.': [3737], 'Berkey': [3740], 'Physiol.': [3748], '280:': [3750], 'C1403-C1411Crossref': [3751], 'C6-Cer-coated': [3757], 'balloon': [3758], 'catheters': [3759], 'prevent': [3760], 'stretch-induced': [3761], 'neointimal': [3762], 'hyperplasia': [3763], 'rabbit': [3765], 'carotid': [3766], 'arteries': [3767], 'inactivating': [3795], 'ERK': [3796], 'signaling': [3799], 'thereby': [3801], 'inducing': [3802], 'cycle': [3804], 'arrest': [3805], 'stretch-injured': [3807], 'Based': [3838], 'published': [3840], 'reports,': [3841], 'expect': [3844], 'controls,': [3855], 'opposite': [3860], '3).': [3862], 'deserves': [3871, 4182], 'investigation.': [3873, 4184], '65%': [3899], 'associated': [3903], 'lipoproteins,': [3905], 'where': [3906], 'HDL': [3907, 3949, 3974], 'carrier': [3911], '(33Okajima': [3912], '2002;': [3917], '1582:': [3918], '132-137Crossref': [3919], '(209)': [3922], 'debate': [3928], 'serum': [3934, 4010], 'anti-atherogenic': [3940, 4298], 'mediator.': [3941], 'hand,': [3945, 4009], 'bind': [3954], 'S1P/Edg': [3956], 'receptors': [3957, 4088], 'endothelial': [3960, 3976, 4090], 'and,': [3962], 'reason,': [3965], 'probably': [3966], 'mediates': [3967], 'anti-inflammatory': [3971], 'actions': [3972], '(34Kimura': [3978, 4095], 'Sato': [3980, 4097, 4125], 'Malchinkhuu': [3982, 4099], 'Tomura': [3984, 4101, 4129], 'H.': [3985, 4102, 4130], 'Tamama': [3986, 4103], 'Kuwabara': [3988, 4105, 4133], 'Murakami': [3990, 4107], 'Okajima': [3992, 4109, 4137], '1283-1288Crossref': [4000, 4117], '(206)': [4003, 4120], 'remarkably': [4017], 'strong': [4018], 'predictor': [4019], 'occurrence': [4023], 'severity': [4026], 'stenosis': [4029], '(35Deutschman': [4035], 'D.H.': [4036], 'Carstens': [4037], 'J.S.': [4038], 'Klepper': [4039], 'Smith': [4041], 'Page': [4043], 'M.T.': [4044], 'Young': [4045], 'T.R.': [4046], 'Gleason': [4047], 'Nakajima': [4049], 'Sabbadini': [4051], 'R.A.': [4052], 'Heart': [4054], '146:': [4057], '62-68Crossref': [4058], '(157)': [4061], 'noted': [4067], '>200': [4077], 'needed': [4084], 'activate': [4086], '∼100': [4093], '36Murata': [4123], 'Kon': [4127], 'Yanagita': [4131], 'Ui': [4135], '352:': [4142], '809-815Crossref': [4143], '(359)': [4146], '<100': [4155], 'II)': [4161], 'pathological': [4164], 'relevance': [4165], '(37Johnson': [4202, 4263], 'phycoerythrin-labeled': [4221], 'anti-CD3': [4222], 'antibodies': [4223], 'flow': [4225], 'cytometry': [4226], 'circulation,': [4239], 'find': [4244], 'shown),': [4249], 'confirming': [4250], 'summary,': [4281], 'mediated': [4284], 'little': [4306]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2014959138', 'counts_by_year': [{'year': 2024, 'cited_by_count': 15}, {'year': 2023, 'cited_by_count': 15}, {'year': 2022, 'cited_by_count': 19}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 18}, {'year': 2019, 'cited_by_count': 22}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 12}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 22}, {'year': 2012, 'cited_by_count': 15}], 'updated_date': '2024-12-14T19:49:34.402473', 'created_date': '2016-06-24'}
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