Publication Information

{'id': 'https://openalex.org/W2014855145', 'doi': 'https://doi.org/10.1089/hum.1997.8.4-423', 'title': 'Adenovirus-Mediated Gene Transfer of Ciliary Neurotrophic Factor Can Prevent Photoreceptor Degeneration in the Retinal Degeneration (<i>rd</i>) Mouse', 'display_name': 'Adenovirus-Mediated Gene Transfer of Ciliary Neurotrophic Factor Can Prevent Photoreceptor Degeneration in the Retinal Degeneration (<i>rd</i>) Mouse', 'publication_year': 1997, 'publication_date': '1997-03-01', 'ids': {'openalex': 'https://openalex.org/W2014855145', 'doi': 'https://doi.org/10.1089/hum.1997.8.4-423', 'mag': '2014855145', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9054517'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1089/hum.1997.8.4-423', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S39730559', 'display_name': 'Human Gene Therapy', 'issn_l': '1043-0342', 'issn': ['1043-0342', '1557-7422'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320443', 'host_organization_name': 'Mary Ann Liebert, Inc.', 'host_organization_lineage': ['https://openalex.org/P4310320443'], 'host_organization_lineage_names': ['Mary Ann Liebert, Inc.'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5090104664', 'display_name': 'Michel Cayouette', 'orcid': 'https://orcid.org/0000-0003-4655-9048'}, 'institutions': [{'id': 'https://openalex.org/I43406934', 'display_name': 'Université Laval', 'ror': 'https://ror.org/04sjchr03', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I43406934']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Michel Cayouette', 'raw_affiliation_strings': ['Laboratoire de Transfert de Gènes, Centre de Recherche Université Laval Robert-Giffard, Beauport, Québec, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Transfert de Gènes, Centre de Recherche Université Laval Robert-Giffard, Beauport, Québec, Canada.', 'institution_ids': ['https://openalex.org/I43406934']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103421767', 'display_name': 'Claude Gravel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I43406934', 'display_name': 'Université Laval', 'ror': 'https://ror.org/04sjchr03', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I43406934']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'Claude Gravel', 'raw_affiliation_strings': ['Address reprint requests to: Dr. Claude Gravel, Laboratoire de Transfert de Gènes, Centre de Recherche Université Laval Robert-Giffard, Local F-7500, 2601 de la Canardière, Beauport, Québec, Canada, G1J 2G3'], 'affiliations': [{'raw_affiliation_string': 'Address reprint requests to: Dr. Claude Gravel, Laboratoire de Transfert de Gènes, Centre de Recherche Université Laval Robert-Giffard, Local F-7500, 2601 de la Canardière, Beauport, Québec, Canada, G1J 2G3', 'institution_ids': ['https://openalex.org/I43406934']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5103421767'], 'corresponding_institution_ids': ['https://openalex.org/I43406934'], 'apc_list': None, 'apc_paid': None, 'fwci': 5.016, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 222, 'citation_normalized_percentile': {'value': 0.96391, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '8', 'issue': '4', 'first_page': '423', 'last_page': '430'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10691', 'display_name': 'Retinal Development and Disorders', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10691', 'display_name': 'Retinal Development and Disorders', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10613', 'display_name': 'Virus-based gene therapy research', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 0.9907, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ciliary-neurotrophic-factor', 'display_name': 'Ciliary neurotrophic factor', 'score': 0.8706166}, {'id': 'https://openalex.org/keywords/outer-nuclear-layer', 'display_name': 'Outer nuclear layer', 'score': 0.7923417}, {'id': 'https://openalex.org/keywords/photoreceptor-cell', 'display_name': 'Photoreceptor cell', 'score': 0.7264395}], 'concepts': [{'id': 'https://openalex.org/C2781114197', 'wikidata': 'https://www.wikidata.org/wiki/Q847057', 'display_name': 'Retinitis pigmentosa', 'level': 3, 'score': 0.9239677}, {'id': 'https://openalex.org/C68710172', 'wikidata': 'https://www.wikidata.org/wiki/Q14906191', 'display_name': 'Ciliary neurotrophic factor', 'level': 4, 'score': 0.8706166}, {'id': 'https://openalex.org/C2781040256', 'wikidata': 'https://www.wikidata.org/wiki/Q7316761', 'display_name': 'Retinal degeneration', 'level': 3, 'score': 0.8235245}, {'id': 'https://openalex.org/C2778231335', 'wikidata': 'https://www.wikidata.org/wiki/Q4113701', 'display_name': 'Outer nuclear layer', 'level': 3, 'score': 0.7923417}, {'id': 'https://openalex.org/C2780916184', 'wikidata': 'https://www.wikidata.org/wiki/Q748049', 'display_name': 'Photoreceptor cell', 'level': 3, 'score': 0.7264395}, {'id': 'https://openalex.org/C2777093970', 'wikidata': 'https://www.wikidata.org/wiki/Q169342', 'display_name': 'Retina', 'level': 2, 'score': 0.5704956}, {'id': 'https://openalex.org/C47870650', 'wikidata': 'https://www.wikidata.org/wiki/Q4682229', 'display_name': 'Gene therapy of the human retina', 'level': 4, 'score': 0.55709034}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5227618}, {'id': 'https://openalex.org/C160539049', 'wikidata': 'https://www.wikidata.org/wiki/Q3064187', 'display_name': 'Neurotrophic factors', 'level': 3, 'score': 0.5095761}, {'id': 'https://openalex.org/C2780827179', 'wikidata': 'https://www.wikidata.org/wiki/Q422001', 'display_name': 'Retinal', 'level': 2, 'score': 0.44518113}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.22276983}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.14207259}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.05655098}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000256', 'descriptor_name': 'Adenoviridae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D010786', 'descriptor_name': 'Photoreceptor Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012174', 'descriptor_name': 'Retinitis Pigmentosa', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D012174', 'descriptor_name': 'Retinitis Pigmentosa', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000256', 'descriptor_name': 'Adenoviridae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020934', 'descriptor_name': 'Ciliary Neurotrophic Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003001', 'descriptor_name': 'Cloning, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015316', 'descriptor_name': 'Genetic Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007267', 'descriptor_name': 'Injections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D012174', 'descriptor_name': 'Retinitis Pigmentosa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1089/hum.1997.8.4-423', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S39730559', 'display_name': 'Human Gene Therapy', 'issn_l': '1043-0342', 'issn': ['1043-0342', '1557-7422'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320443', 'host_organization_name': 'Mary Ann Liebert, Inc.', 'host_organization_lineage': ['https://openalex.org/P4310320443'], 'host_organization_lineage_names': ['Mary Ann Liebert, Inc.'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9054517', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.82, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1516430698', 'https://openalex.org/W1528956923', 'https://openalex.org/W1538214352', 'https://openalex.org/W1843009580', 'https://openalex.org/W1875362341', 'https://openalex.org/W1964836954', 'https://openalex.org/W1974084948', 'https://openalex.org/W1991372941', 'https://openalex.org/W1992009563', 'https://openalex.org/W1997772006', 'https://openalex.org/W2009761723', 'https://openalex.org/W2011820509', 'https://openalex.org/W2015963628', 'https://openalex.org/W2018068734', 'https://openalex.org/W2025299744', 'https://openalex.org/W2027632084', 'https://openalex.org/W2040541933', 'https://openalex.org/W2041102000', 'https://openalex.org/W2045112729', 'https://openalex.org/W2060230153', 'https://openalex.org/W2064304960', 'https://openalex.org/W2066556283', 'https://openalex.org/W2074208335', 'https://openalex.org/W2080070323', 'https://openalex.org/W2082995803', 'https://openalex.org/W2090256161', 'https://openalex.org/W2116951270', 'https://openalex.org/W2123640323', 'https://openalex.org/W2133607143', 'https://openalex.org/W2142761289', 'https://openalex.org/W2152890178', 'https://openalex.org/W2340773711', 'https://openalex.org/W51237493'], 'related_works': ['https://openalex.org/W4297474818', 'https://openalex.org/W3159635619', 'https://openalex.org/W2916057263', 'https://openalex.org/W2605042492', 'https://openalex.org/W2472128050', 'https://openalex.org/W2471558467', 'https://openalex.org/W2115104922', 'https://openalex.org/W2023239448', 'https://openalex.org/W2014855145', 'https://openalex.org/W1987966362'], 'abstract_inverted_index': {'Mutations': [0], 'in': [1, 17, 35, 58, 91, 179, 204, 208, 258, 271, 294], 'the': [2, 5, 36, 43, 53, 59, 96, 102, 107, 173, 180, 194, 227, 236, 254, 259, 272, 285, 312, 315, 329], 'β-subunit': [3], 'of': [4, 25, 39, 47, 55, 70, 82, 95, 101, 119, 124, 161, 177, 188, 198, 211, 221, 230, 235, 243, 253, 284, 307, 314, 338], 'cGMP': [6], 'phosphodiesterase': [7], 'gene': [8, 78], '(βPDE)': [9], 'can': [10, 318], 'cause': [11], 'photoreceptor': [12, 33, 48, 120, 206, 256, 321], 'degeneration': [13], 'leading': [14], 'to': [15, 31, 171, 311], 'blindness': [16], 'humans,': [18], 'dogs,': [19], 'and': [20, 42, 183, 233], 'mice.': [21], 'Since': [22], 'intravitreal': [23, 68, 159], 'administration': [24, 141, 197], 'trophic': [26, 309], 'factors': [27, 200], 'has': [28, 168], 'been': [29, 169, 247], 'shown': [30, 170], 'reduce': [32], 'death': [34, 167], 'Royal': [37], 'College': [38], 'Surgeons': [40], 'rat': [41], 'light': [44, 286], 'overexposure': [45], 'models': [46, 187], 'degeneration,': [49], 'we': [50], 'have': [51, 246], 'tested': [52], 'possibility': [54, 195], 'rescuing': [56], 'photoreceptors': [57, 178], 'rd': [60, 181, 273, 316], 'mouse': [61, 182, 317], 'using': [62], 'ciliary': [63], 'neurotrophic': [64, 199], 'factor': [65, 310], '(CNTF).': [66], 'Following': [67], 'injection': [69, 160], 'an': [71, 281], 'adenoviral': [72], 'vector': [73, 140], 'encoding': [74], 'a': [75, 128, 218, 240, 262, 266, 278, 289, 308, 339], 'ngf/cntf': [76], 'fusion': [77], 'into': [79], 'one': [80], 'eye': [81], 'rd/rd': [83], 'mice,': [84], 'many': [85, 184], 'strong': [86], 'CNTF-immunoreactive': [87], 'profiles': [88], 'are': [89], 'detected': [90], 'various': [92], 'cell': [93, 166], 'types': [94], 'injected': [97], 'eyes.': [98], 'Semiquantitative': [99], 'analysis': [100], 'corresponding': [103], 'retinae': [104], 'reveals': [105], 'that': [106, 123, 196, 304, 346], 'photoreceptor-containing': [108], 'layer': [109], '(outer': [110], 'nuclear': [111], 'layer,': [112], 'or': [113, 132], 'ONL)': [114], 'retains': [115], 'significantly': [116, 319], 'more': [117], 'rows': [118], 'nuclei': [121], 'than': [122], 'eyes': [125], 'treated': [126], 'with': [127], 'control': [129], '(LacZ)': [130], 'vector,': [131], 'untreated,': [133], 'for': [134, 249], 'at': [135], 'least': [136], '18': [137], 'days': [138, 157], 'after': [139, 158], '(the': [142], 'longest': [143], 'survival': [144], 'time': [145], 'analyzed).': [146], 'A': [147], 'smaller,': [148], 'but': [149, 341], 'significant,': [150], 'protective': [151], 'effect': [152], 'was': [153], 'also': [154, 269, 291], 'seen': [155], '9': [156], 'recombinant': [162], 'CNTF.': [163], 'Because': [164], 'apoptotic': [165], 'be': [172], 'common': [174, 263], 'terminal': [175], 'fate': [176], 'other': [185], 'animal': [186], 'retinitis': [189, 212], 'pigmentosa,': [190], 'these': [191], 'results': [192], 'suggest': [193, 345], 'may': [201, 333], 'prove': [202], 'beneficial': [203], 'reducing': [205], 'loss': [207, 229, 252, 267], 'multiple': [209], 'forms': [210], 'pigmentosa.': [213], 'Retinitis': [214], 'pigmentosa': [215], '(RP)': [216], 'is': [217, 261, 268], 'heterogenous': [219], 'group': [220], 'human': [222, 296], 'inherited': [223], 'retinopathies': [224], 'characterized': [225], 'by': [226], 'progressive': [228], 'night': [231], 'vision': [232], 'restriction': [234], 'visual': [237], 'field.': [238], 'Although': [239, 323], 'wide': [241], 'spectrum': [242], 'electroretinographic': [244], 'abnormalities': [245], 'described': [248], 'different': [250], 'mutations,': [251], 'light-transducing': [255], 'cells': [257], 'retina': [260, 313], 'denominator.': [264], 'Such': [265], 'encountered': [270], 'mouse,': [274], 'which': [275], 'suffers': [276], 'from': [277, 299], 'mutation': [279], 'inactivating': [280], 'important': [282], 'component': [283, 290], 'transduction': [287], 'chain,': [288], 'found': [292], 'mutated': [293], 'some': [295], 'families': [297], 'affected': [298], 'RP.': [300], 'We': [301, 344], 'show': [302], 'here': [303], 'virus-mediated': [305], 'delivery': [306], 'delay': [320], 'loss.': [322], 'this': [324, 347], 'treatment': [325], 'does': [326], 'not': [327], 'correct': [328], 'genetic': [330], 'defect,': [331], 'it': [332], 'help': [334], 'prevent': [335], 'further': [336, 350], 'deterioration': [337], 'reduced,': [340], 'useful': [342], 'vision.': [343], 'issue': [348], 'deserves': [349], 'attention.': [351]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2014855145', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-12-08T05:06:48.291023', 'created_date': '2016-06-24'}