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[289], 'agent': [290], 'bioterrorism': [292], 'classified': [294], 'biosecurity': [296], 'level': [297], '4': [298], 'pathogens.The': [299], 'proteinsHeV': [302], 'share': [305, 408, 428, 515], 'similar': [306, 430], 'replication': [309], 'strategies,': [310], 'display': [312], 'high': [313, 550, 1014, 1387, 1464], 'similarities': [314], 'sequences': [317], '(specific': [318], 'genes': [319, 1028], 'sharing': [320], '70–88%': [321], 'nucleotide': [322], 'homologies)': [323], '[4].': [324], 'large': [326], 'enveloped': [327], 'ssRNA': [328], 'negative': [331], 'polarity': [332], 'produce': [333, 580], 'six': [334], 'structural': [335], 'three': [337], 'proteins:': [339, 1896], 'V,': [340, 522, 2013, 2071], 'W': [341, 401, 426, 467, 523, 583, 762, 858, 1033, 1172, 1686, 1856, 1951], 'C.': [343], 'All': [344], 'proteins': [346, 402, 427, 456, 536, 606, 612, 810, 943, 973, 1004, 1008, 1039, 1069, 1098, 1123, 1220, 1232, 1277, 1687, 1819, 1952, 2020], 'derived': [348], 'P': [351, 364, 414, 433, 497, 525, 575, 1001, 1998, 2150], 'gene,': [352], 'which': [353, 370, 877, 959, 1121, 1148, 1197, 1380, 1477], 'codes': [354], 'phosphoprotein': [357, 1674], 'P.': [358], 'As': [359, 840], 'other': [361, 647, 694, 1413, 1526, 2376], 'this': [363, 887, 1567, 2417], 'gene': [365, 498, 576, 1675, 2151], 'contains': [366], 'editing': [368, 398, 406, 571, 1677], 'site,': [369], 'can': [371, 537], 'introduce': [372], 'G': [373], 'residues': [374], 'sequence': [378], 'leads': [380, 949], 'reading': [383, 493], 'frameshift': [384], 'course': [387], 'RNA': [389, 671, 751, 1735, 1746, 1823], 'translation': [390], '[5].': [391], 'The': [392, 669, 820, 945, 999, 1309, 1522, 2018, 2372], 'resulting': [393], 'V': [394, 424, 462, 581, 733, 798, 1003, 1684, 1776, 1800, 1818, 1949], '(+1G': [395], 'at': [396, 404, 1058], 'site)': [399, 407], '(+2G': [403], 'N-terminal': [410, 438], 'part': [411, 844], 'protein,': [415, 584], 'but': [416, 440, 1767], 'own': [419, 445], 'specific': [420, 449, 1205], 'C-terminal': [421, 450], 'part.': [422], 'Thus,': [423], 'some': [429, 1168], 'properties': [431], 'protein': [434, 463, 505, 512, 526, 734, 740, 747, 763, 799, 859, 871, 897, 977, 1034, 1117, 1173, 1248, 1857, 2080], 'through': [435, 447], 'common': [437, 1772, 1955], 'part,': [439], 'addition': [442, 801, 851], 'properties,': [446], 'parts.': [451], 'For': [452], 'example,': [453], 'different': [458, 1059, 1448, 1581], 'intracellular': [459, 906], 'distribution:': [460], 'is': [464, 468, 506, 699, 842, 878, 889, 1265, 1381, 1456, 1770], 'cytosolic,': [465], 'whereas': [466, 1401], 'nuclear': [469, 766, 892, 1020, 1966], 'show': [472], 'differences': [473, 1155, 1451], 'ability': [476, 1138], 'interact': [478, 1820], 'innate': [481, 531, 541, 608, 667, 915, 1063, 1101, 1315, 1740], 'immune': [482, 532, 542, 609, 719, 726, 1064, 1102, 1741], 'system.': [483], 'Moreover,': [484, 868], 'due': [485, 793], 'existence': [488], 'alternative': [491], 'open': [492], 'frame': [494], 'inside': [495], 'sequence,': [499], 'third': [501, 560], 'C': [504, 511, 870, 896, 1247, 1763, 1895, 2079], 'produced': [507], 'therefore,': [509], 'does': [513, 586], 'not': [514, 587, 643, 1183, 1407, 1768], 'any': [516, 1533, 2383], 'amino': [517], 'acid': [518], 'homology': [519], '[5].Interaction': [527], 'host': [530, 540, 1075, 1625, 2085], 'systemThe': [533], 'block': [538, 1142], 'response,': [543], 'becoming': [545], 'virulence': [546], 'factors': [547], 'responsible': [548, 879], 'pathogenicity': [551, 1388, 1426, 2029], 'these': [553, 629, 754, 1219, 1434, 1484], 'viruses.': [554], 'Unlike': [555], 'NiV,': [558], 'discovered': [562], 'member': [563], 'genus,': [566], 'Cedar': [567, 779, 1713], 'virus,': [568, 1649, 2236], 'lacks': [569], 'site': [572], 'its': [574, 964, 1188], 'cannot': [579], 'nor': [582], 'clinical': [589], 'tested': [592], 'animal': [593], 'models': [594], 'such': [595], 'ferrets': [597], 'guinea': [599], '[6].': [601], 'Interactions': [602], 'signaling': [610, 678, 818, 848, 866, 907, 935, 947, 1065, 1103, 1144, 1324, 1373, 1868, 2049, 2179, 2207], 'pathway': [611, 849, 865, 948], 'allows': [613, 1858], 'escape': [615, 1072], 'cellular': [617, 1076], 'pathogen': [618], 'recognition': [619, 672, 752, 831], 'important': [623, 990, 1254], 'pathogenicity.': [626, 1453, 1466], 'Some': [627], 'interactions': [630, 1092, 1286, 1310, 1471], 'been': [632, 782, 1408], 'already': [633], 'described': [634], 'human': [636, 918, 1239, 1377, 1602, 2056, 2156], 'cells,': [637, 1170, 1353], 'nevertheless,': [638], 'mechanisms': [640], 'involved': [641, 700, 828, 1743], 'completely': [644], 'understood': [645], 'targets': [650, 1271], 'may': [651, 1182], 'exist.The': [652], 'RIG-I-like': [653], '(RLRs)': [655], 'cytosolic': [657, 875], 'recognize': [660, 813], 'dsRNAs,': [661], 'leading': [662, 680], 'triggering': [665, 702], 'immunity.': [668], 'by': [673, 753, 903, 1056, 1153, 1347, 1360, 1516, 1798, 1893, 2366], 'RLRs': [675], 'sets': [676], 'off': [677], 'pathways,': [679, 908, 1066, 1104], 'production': [683, 709, 789, 922, 970, 1565, 2205, 2415], 'type': [685, 1343, 1922], '1': [686], 'IFN-α': [687], '-β': [689], '(IFN-I),': [690], 'proinflammatory': [695, 711, 1260, 2086], 'cytokines': [696], '[7].': [697, 839], 'IFN-I': [698, 900, 930, 934, 1143, 1323, 1340], 'antivirus': [704], 'defense': [706, 966, 2263], 'cytokines,': [712], 'allowing': [713], 'recruitment': [714], 'cells': [716, 919, 937, 961, 995, 1241, 1378, 2120], 'system': [720], 'development': [722], 'adaptive': [725], 'response.': [727, 2160], 'In': [728, 757, 777, 1030], 'cytosol,': [730, 1179], 'interacts': [735, 872, 1035], 'directly': [736], 'MAD5': [739], '[8,9]': [741], 'indirectly': [743], 'RIG-I': [746], '[10],': [748], 'inhibiting': [750], 'RLRs.': [756], 'nucleus,': [759], 'blocks': [764], 'transduction': [767], 'signal,': [768], 'disrupting': [769], 'phosphorylated': [771], 'form': [772], 'IRF3': [775, 841, 861], '[11].': [776, 867], 'agreement,': [778], 'has': [781], 'shown': [783, 1243, 1326], 'much': [786, 1127], 'higher': [787, 1128], 'IFN-β': [788], 'than': [790, 1130, 1414], 'HeV,': [791], 'possibly': [792], 'absence': [796], '[6].In': [800], 'RLRs,': [803], 'Toll-like': [805, 1865, 1899], '(TLRs)': [807], 'transmembrane': [809, 929], 'also': [812, 862], 'RNAs': [815, 838], 'trigger': [817], 'pathways.': [819, 1869], 'TLRs': [821], '3,': [822, 1631], '7': [823], '8': [825], 'especially': [827], 'single': [833], 'or': [834, 1504, 1529, 1535, 1542, 1549, 2354, 2379, 2385, 2392, 2399], 'double': [835], 'stranded': [836], 'TLR': [847, 864], 'RLR': [854], 'pathway,': [855], 'interaction': [856], 'disturbs': [863, 899], 'kinase,': [876], 'phosphorylation': [882, 888], 'IRF7': [884], '[12].': [885], 'essential': [890, 1457], 'transduction,': [893], 'consequently': [898], 'production.': [901], 'Therefore,': [902, 1055], 'interacting': [904], 'disrupt': [910], 'sensors': [912], 'immunity': [916, 1316], 'and,': [920], 'thus,': [921], 'IFN-I.Blocking': [924], 'danger': [927], 'signalThe': [928], 'receptor': [931, 1866, 1900], '(IFNAR)': [932], 'initiates': [933], 'via': [938, 1996], 'activation': [940, 952, 1024, 1961], 'STAT': [942, 1007, 1038], '[13].': [944], 'IFNAR': [946], 'panel': [955], 'interferon-stimulated': [957, 1027], 'genes,': [958], 'allow': [960, 1198], 'engage': [963], 'antiviral': [965, 972, 991, 1236, 2111, 2159, 2262, 2291], 'state,': [967], '(such': [974], 'kinase': [978], 'R': [979], 'capable': [980], 'cycle': [983], 'disruption)': [984], 'therefore': [986], 'provides': [987], 'protection': [992], 'uninfected': [994], 'far.': [998], 'confine': [1005], 'cytosol': [1011, 1053], 'molecular': [1015], 'weight': [1016], 'complex,': [1017], 'preventing': [1018], 'translocation': [1021], '[14].': [1029], 'addition,': [1031], 'nucleus': [1042, 1995], 'sequestrate': [1044], 'interfere': [1047], 'recycling': [1050], 'towards': [1051, 1086], '[15].': [1054], 'acting': [1057], 'levels': [1060], 'on': [1061, 2311], 'enable': [1070], 'defenses.However,': [1077], 'numerous': [1078], 'gray': [1079, 1109], 'areas': [1080], 'still': [1081, 1106, 1278], 'persistDespite': [1082], 'steps': [1084], 'made': [1085], 'better': [1088, 1213, 1459], 'present': [1107], 'many': [1108], 'areas.': [1110], 'Numerous': [1111], 'results': [1112, 1135], 'were': [1113, 1145, 1242, 1345], 'obtained': [1114], 'transfection': [1118], 'context,': [1119], 'expressed': [1125], 'quantities': [1129], 'during': [1131, 1221, 2052, 2211], 'natural': [1132, 1305, 1428, 2254], 'infection.': [1133, 2185], 'Differing': [1134], 'reported': [1146, 1396, 1409], '[16–18],': [1147], 'could': [1149], 'partly': [1151], 'explained': [1152], 'experimental': [1158], 'protocols': [1159], 'used': [1160], 'analyzed': [1163], 'types.': [1165], 'Indeed,': [1166], 'endothelial': [1169, 1240, 2119, 2157], 'seems': [1174], 'remain': [1176, 1279], 'where': [1180], 'it': [1181, 1264], 'play': [1187, 1328, 2024], 'key': [1189, 2026], '[19].': [1191], 'Development': [1192], 'reverse': [1194], 'genetic': [1195], 'systems,': [1196], 'generation': [1200], 'recombinant': [1202], 'bearing': [1204], 'mutations': [1206], 'proteins,': [1209], 'contributed': [1211], '[16,20].': [1223], 'Both': [1224], 'distinct': [1225, 1288], 'overlapping': [1227, 2145], 'roles': [1228, 2146], 'modulating': [1234, 2154], 'response': [1237, 2087], '[20]': [1244], 'was': [1249, 1325, 1395, 1514, 1561, 2364, 2411], 'demonstrated': [1250], 'function': [1255], 'regulation': [1258], 'responses': [1261, 2114], '[18].': [1262], 'Nevertheless,': [1263], 'likely': [1267], 'additional': [1269], 'elucidated.Lessons': [1282], 'differential': [1284], 'virus–host': [1285], 'speciesAlthough': [1289], 'provokes': [1291], 'diseases': [1293], 'hosts,': [1297, 1306], 'seem': [1299], 'asymptomatic': [1302], 'bats.': [1308, 1721], 'bat': [1314, 1352, 2216], 'far': [1318], 'being': [1320], 'understood.': [1321], 'Although': [1322], 'critical': [1330], 'protecting': [1333], 'mice': [1334, 2181], '[21],': [1338], 'both': [1339, 1862, 2082], 'IFN': [1342], 'III': [1344], 'inhibited': [1346], 'suggesting': [1354], 'control': [1357], 'unidentified': [1363], 'mechanism': [1364], '[22].': [1365], 'Surprisingly,': [1366], 'same': [1368], 'authors': [1369, 1523, 2373], 'found': [1370], 'interferon': [1372, 1829, 1903, 1924, 2178], 'remains': [1374, 2050], 'effective': [1375], '[17],': [1379], 'difficult': [1382], 'align': [1384], 'NiV.': [1390], 'Recently,': [1391], 'rats': [1398], 'China,': [1400, 2241], 'until': [1402], 'now': [1403], 'wild': [1411], 'animals': [1412], '[23].': [1417], 'This': [1418], 'discovery': [1420], 'makes': [1421], 'study': [1423, 1495, 2345], 'hosts': [1429], 'even': [1430], 'more': [1431], 'important.Faced': [1432], 'questions,': [1435], 'studies': [1436], 'progress': [1439], 'try': [1441], 'understand': [1443], 'host–pathogen': [1445], 'relationship': [1446], 'Additional': [1454], 'analysis': [1455], 'comprehend': [1460], 'basis': [1462], 'Further': [1467], 'elucidation': [1468], 'virus-host': [1470], 'will': [1472], 'provide': [1473], 'insights': [1475], 'develop': [1479], 'novel': [1480, 1716], 'therapeutic': [1481], 'strategies': [1482], 'against': [1483, 2115], 'lethal': [1486, 2183], 'emergent': [1487, 1652], 'viruses.DisclaimerThe': [1488], 'funding': [1489, 2339], 'bodies': [1490, 2340], 'had': [1491, 2341], 'no': [1492, 1525, 2342, 2375], 'design,': [1496, 2346], 'data': [1497, 2347], 'collection': [1498, 2348], 'analysis,': [1500, 2350], 'decision': [1501, 2351], 'publish,': [1503, 2353], 'preparation': [1505, 2355], 'manuscript.Financial': [1508, 2358], 'competing': [1510, 2360], 'interests': [1511, 2361], 'disclosureThis': [1512, 2362], 'work': [1513, 2363], 'supported': [1515, 2365], 'INSERM,': [1517, 2367], 'ANR': [1518, 2368], 'MIE': [1519, 2369], 'Astrid.': [1521, 2371], 'relevant': [1527, 2377], 'affiliations': [1528, 2378], 'financial': [1530, 1539, 1543, 2380, 2389, 2393], 'involvement': [1531, 2381], 'organization': [1534, 2384], 'entity': [1536, 2386], 'interest': [1540, 2390], 'conflict': [1544, 2394], 'subject': [1547, 2397], 'matter': [1548, 2398], 'materials': [1550, 2400], 'discussed': [1551, 2401], 'manuscript': [1554, 2404], 'apart': [1555, 2405], 'those': [1557, 2407], 'disclosed.No': [1558, 2408], 'writing': [1559, 2409], 'assistance': [1560, 2410], 'utilized': [1562, 2412], 'manuscript.References1': [1568], 'Eaton': [1569], 'BT,': [1570], 'Broder': [1571], 'CC,': [1572], 'Middleton': [1573], 'D,': [1574, 1845, 2103], 'Wang': [1575, 2046, 2202], 'L-F.': [1576, 2047, 2203], 'Hendra': [1577], 'viruses:': [1580, 1736], 'dangerous.': [1583], 'Nat.': [1584, 1629], 'Rev.': [1585], 'Microbiol.': [1586, 1931], '4(1),': [1587], '23–35': [1588], '(2006).Crossref,': [1589], 'Medline,': [1590, 1613, 1634, 1658, 1700, 1754, 1782, 1807, 1836, 1875, 1910, 1935, 1974, 2006, 2039, 2064, 2096, 2127, 2192], 'CAS,': [1591, 1659, 1701, 1755, 1783, 1808, 1837, 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1664], 'BH,': [1638, 1665], 'Tamin': [1639], 'A,': [1640, 1942], 'Ksiazek': [1641], 'TG': [1642], 'Molecular': [1645], 'characterization': [1646], 'newly': [1651], 'paramyxovirus.': [1653], 'Virology': [1654, 1778, 2123], '271(2),': [1655], '334–349': [1656], '(2000).Crossref,': [1657], 'Scholar5': [1661], 'Lo': [1662, 2100, 2131], 'MK,': [1663, 2101, 2132], 'Mungall': [1666], 'BA': [1667], 'Determination': [1670], 'mRNA': [1676], 'frequencies': [1678], 'detection': [1680], 'C,': [1683, 1708, 2069, 2171], 'virus-infected': [1692], 'cells.': [1693], 'J.': [1694, 1749, 1802, 1831, 1870, 1969, 2001, 2059, 2091, 2186], 'Gen.': [1695], 'Virol.': [1696, 1750, 1803, 1832, 1871, 1970, 2002, 2060, 2092], '90(2),': [1697], '398–404': [1698], 'Scholar6': [1703], 'Marsh': [1704, 2044, 2198], 'GA,': [1705, 2045, 2199], 'Jong': [1707], 'Barr': [1709], 'JA': [1710], 'virus:': [1714], 'isolated': [1718], 'Australian': [1720], 'PLoS': [1722, 2034, 2161, 2219], 'Pathog.': [1723], '8(8),': [1724], 'e1002836': [1725], 'Scholar7': [1728], 'Jensen': [1729], 'S,': [1730], 'Thomsen': [1731], 'AR.': [1732], 'Sensing': [1733], 'review': [1738], 'recognizing': [1745], 'invasion.': [1748], '86(6),': [1751], '2900–2910': [1752], 'Scholar8': [1757], 'Childs': [1758, 1786, 1811], 'K,': [1759, 1812], 'Stock': [1760], 'N,': [1761], 'Ross': [1762], 'mda-5,': [1766], 'RIG-I,': [1769], 'target': [1773], 'paramyxovirus': [1775, 1799, 1894], 'proteins.': [1777, 1801], '359(1),': [1779], '190–200': [1780], '(2007).Crossref,': [1781], 'Scholar9': [1785], 'KS,': [1787], 'Andrejeva': [1788], 'J,': [1789], 'Randall': [1790, 1813], 'RE,': [1791], 'Goodbourn': [1792, 1815], 'S.': [1793, 1816], 'Mechanism': [1794], 'mda-5': [1796], 'inhibition': [1797, 1860, 1897], '83(3),': [1804], '1465–1473': [1805], 'Scholar10': [1810], 'R,': [1814], 'Paramyxovirus': [1817], 'helicase': [1824], 'LGP2': [1825], 'inhibit': [1827, 1959], 'RIG-I-dependent': [1828], 'induction.': [1830, 1904], '86(7),': [1833], '3411–3421': [1834], 'Scholar11': [1839], 'Shaw': [1840, 1939, 1982], 'ML,': [1841, 1940, 1983, 2201], 'Cardenas': [1842], 'WB,': [1843], 'Zamarin': [1844], 'Palese': [1846, 1943], 'P,': [1847, 1944], 'Basler': [1848, 1945, 1986], 'CF.': [1849, 1946, 1987, 2142], 'Nuclear': [1850], 'localization': [1851], 'virus-': [1863], '3-triggered': [1867], '79(10),': [1872], '6078–6088': [1873], '(2005).Crossref,': [1874], 'Scholar12': [1878], 'Yamaguchi': [1879], 'M,': [1880, 1884, 1886, 2011], 'Kitagawa': [1881], 'Y,': [1882], 'Zhou': [1883], 'Itoh': [1885], 'Gotoh': [1887], 'B.': [1888], 'An': [1889], 'anti-interferon': [1890], 'activity': [1891], 'shared': [1892], '7/9-dependent': [1901], 'alpha': [1902], 'FEBS': [1905], 'Lett.': [1906], '588(1),': [1907], '28–34': [1908], '(2014).Crossref,': [1909, 2248], 'Scholar13': [1913], 'Wilson': [1914], 'EB,': [1915], 'Brooks': [1916], 'DG.': [1917], 'Decoding': [1918], 'complexity': [1920], 'I': [1923, 2177], 'treat': [1926], 'persistent': [1927], 'infections.': [1929], 'Trends': [1930], '21(12),': [1932], '634–640': [1933], '(2013).Crossref,': [1934, 2191], 'Scholar14': [1938], 'García-Sastre': [1941], 'STAT1-binding': [1956], 'domain': [1957], 'STAT1': [1960, 1992], 'cytoplasmic': [1964], 'compartments,': [1967], 'respectively.': [1968], '78(11),': [1971], '5633–5641': [1972], '(2004).Crossref,': [1973], 'Scholar15': [1977], 'Ciancanelli': [1978], 'MJ,': [1979], 'Volchkova': [1980, 2072], 'VA,': [1981], 'Volchkov': [1984], 'VE,': [1985], 'sequesters': [1990], 'inactive': [1991], 'gene-encoded': [1999], 'mechanism.': [2000], '83(16),': [2003], '7828–7841': [2004], 'Scholar16': [2009], 'Yoneda': [2010], 'Guillaume': [2012, 2070], 'Sato': [2014], 'H': [2015], 'experimentally': [2031], 'infected': [2032], 'animals.': [2033], 'ONE': [2035, 2162, 2220], '5(9),': [2036], 'e12709': [2037], '(2010).Crossref,': [2038, 2126], 'Scholar17': [2041], 'Virtue': [2042, 2196], 'ER,': [2043, 2197], 'Interferon': [2048, 2204], 'functional': [2051], 'lines.': [2058, 2218], '85(8),': [2061], '4031–4034': [2062], '(2011).Crossref,': [2063, 2223], 'Scholar18': [2067], 'Mathieu': [2068, 2170], 'VA': [2073], 'Nonstructural': [2076], 'regulates': [2081], 'early': [2084], 'virulence.': [2090], '86(19),': [2093], '10766–10775': [2094], 'Scholar19': [2099], 'Miller': [2102], 'Aljofan': [2104], 'M': [2105, 2173], 'Characterization': [2108], 'inflammatory': [2113], 'neurons.': [2122], '404(1),': [2124], '78–88': [2125], 'Scholar20': [2130], 'Peeples': [2133], 'ME,': [2134], 'Bellini': [2135], 'WJ,': [2136], 'Nichol': [2137], 'ST,': [2138], 'Rota': [2139], 'PA,': [2140], 'Spiropoulou': [2141], 'Distinct': [2143], 'products': [2152], '7(10),': [2163], 'e47790': [2164], 'Scholar21': [2167], 'Dhondt': [2168], 'KP,': [2169], 'Chalons': [2172], 'Type': [2176], 'protects': [2180], '207(1),': [2189], '142–151': [2190], 'Scholar22': [2195], 'Baker': [2200], 'pathways': [2208], 'antagonized': [2210], 'henipavirus': [2212], '6(7),': [2221], 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