Title: Cyclic 3′,5′-nucleotide phosphodiesterase, IV. Two enzymes with different properties from brain
Abstract: Two active peaks of phosphodiesterase, I and II, were resolved by a gel filtration column chromatography of the high speed supernatant of brain extract. The peak II represented Ca++ plus Mg++ dependent phosphodiesterase, the occurence of which in the supernatant of brain extract had been reported (1, 3), while the peak I may be called as “Ca++ independent” and Mg++ dependent phosphodiesterase from its nature. The former decomposed cyclic AMP, cyclic GMP, and cyclic UMP with the stimulatory effect of Ca++ion. The latter, decomposing cyclic GMP at the comparable rate to cyclic AMP, showed negligible activity to cyclic UMP.
Publication Year: 1971
Publication Date: 1971-03-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 92
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