Title: Limitations of the pig‐to‐non‐human primate islet transplantation model
Abstract: XenotransplantationVolume 20, Issue 1 p. 2-4 Commentary Limitations of the pig-to-non-human primate islet transplantation model Martin Wijkstrom, Martin Wijkstrom [email protected] Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USASearch for more papers by this authorRita Bottino, Rita Bottino Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA Division of Immunogenetics, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PASearch for more papers by this authorDavid K.C. Cooper, David K.C. Cooper Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USASearch for more papers by this author Martin Wijkstrom, Martin Wijkstrom [email protected] Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USASearch for more papers by this authorRita Bottino, Rita Bottino Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA Division of Immunogenetics, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PASearch for more papers by this authorDavid K.C. Cooper, David K.C. Cooper Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USASearch for more papers by this author First published: 09 January 2013 https://doi.org/10.1111/xen.12017Citations: 10Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1Graham M, Schuurman H-J. The usefulness and limitations of the diabetic macaque model in evaluating long-term porcine islet xenograft survival. 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The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes – Executive summary. Xenotransplantation 2009; 16: 196–202. 16Cooper DKC, Casu A. The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes – Chapter 4: pre-clinical efficacy and complication data required to justify a clinical trial. Xenotransplantation 2009; 16: 229–238. 17Zhou H, van der Windt DJ, Dons EM et al. A syndrome of severe hypoglycemia and acidosis in young immunosuppressed diabetic monkeys and pigs – association with sepsis. Transplantation 2012; 94: 1187–1191. 18Gaber AO, Fraga D, Kotb M, Lo A, Sabek O, Latif K. Human islet graft function in NOD-SCID mice predicts clinical response in islet transplanted recipients. Transplant Proc 2004; 36: 1108–1110. 19Sabek OM, Fraga DW, Minoru O, McClaren JL, Gaber AO. Assessment of human islet viability using various mouse models. Transplant Proc 2005; 37: 3415–3416. 20Xu BY, Yu Y, Al-Abdullah IH, Kandeel F, Hering B, Wright JR Jr. Long-term survival and function of intraportal porcine and human islet xenografts in nondiabetic nude mice. Transplant Proc 2008; 40: 584–586. Citing Literature Volume20, Issue1January/February 2013Pages 2-4 ReferencesRelatedInformation