Title: NADPH-dependent lipid peroxidation catalyzed by purified NADPH-cytochrome c reductase from rat liver microsomes
Abstract: A purified preparation of rat liver microsomal NADPH-cytochrome c reductase has been shown to catalyze the NADPH-dependent peroxidation of isolated microsomal lipid. In addition to ADP and ferric ion required for NADPH-dependent lipid peroxidation in whole microsomes, this system requires high ionic strength and a critical concentration of EDTA. The peroxidation activity can be inhibited by superoxide dismutase suggesting that the superoxide anion, produced by this flavoprotein, is involved in the lipid peroxidation reaction.
Publication Year: 1972
Publication Date: 1972-08-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 179
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