Publication Information

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239, 800], 'important': [43, 240], 'in': [44, 119, 164, 193, 241, 316, 361, 390, 489, 557, 733, 905, 1077, 1321, 1549, 1576, 1741, 1760, 1794, 1974, 1979, 1986, 2123, 2219, 2263, 2416, 2422, 2684, 2823, 3004, 3012, 3108, 3158, 3236, 3304, 3492, 3499, 3508, 3631, 3635, 3702, 3711, 3729, 3734, 3809, 3824, 3847, 3995, 4001, 4007, 4013, 4368], 'regulation': [46, 122, 243, 319, 879], 'of': [47, 74, 100, 154, 184, 244, 271, 297, 351, 381, 402, 542, 546, 618, 743, 798, 862, 884, 1071, 1108, 1236, 1334, 1416, 1433, 1564, 1735, 1784, 1952, 1956, 1977, 2004, 2096, 2105, 2107, 2117, 2148, 2153, 2164, 2186, 2233, 2244, 2256, 2437, 2474, 2517, 2519, 2536, 2540, 2563, 2606, 2613, 2623, 2637, 2667, 2679, 2698, 2704, 2706, 2834, 2837, 2867, 3037, 3045, 3100, 3105, 3113, 3140, 3152, 3155, 3163, 3176, 3219, 3231, 3258, 3268, 3294, 3301, 3309, 3380, 3405, 3472, 3486, 3503, 3516, 3527, 3530, 3538, 3626, 3638, 3644, 3648, 3687, 3705, 3713, 3725, 3752, 3805, 3807, 3811, 3822, 3979, 4022, 4054, 4068, 4250, 4281, 4301, 4305, 4313, 4351], 'cell': [48, 109, 120, 144, 165, 189, 245, 306, 317, 341, 362, 386, 2165, 2206, 2446, 2465, 2523, 2614, 2964, 3250, 3524, 3797, 4256, 4370], 'apoptosis,': [51, 248], 'including': [52, 249, 620, 806, 895], 'activating': [53, 250], '2': [56, 253, 1199, 3314, 3420, 3512], '(ATF2),': [57, 254], 'Max,': [58, 255, 809], 'cAMP': [59, 256, 419], 'response': [60, 257, 420, 805, 1980], 'element-binding': [61, 258], 'protein-homologous': [62, 259, 423], 'protein/growth': [63, 260], 'arrest': [64, 261, 427, 3234, 3773, 4372], 'DNA': [65, 262, 428, 2328, 2388], 'damage': [66, 263], '153': [67, 264], '(CHDP/GADD153).': [68, 265], 'In': [69, 266, 608, 640, 1311, 2134, 2175, 3514], 'turn,': [70, 267, 558], 'lies': [72, 269], 'downstream': [73, 270], 'Rho': [76, 273, 1764, 2432, 4303], 'family': [77, 274, 484, 1765, 2433], 'GTPases': [78, 275, 1766], 'Cdc42Hs': [79, 163, 175, 185, 276, 360, 372, 382, 1769, 1787, 2129, 2149, 2159], 'Rac1,': [81, 278], 'well': [83, 280, 747, 1089, 1552, 1990], 'at': [85, 147, 282, 344, 2170, 2360, 2449], 'least': [86, 283], 'three': [87, 284, 3838], 'mitogen-activated': [88, 285, 437], '(MAPK)/ERK-kinases': [91, 288], '(MEKs):': [92, 289], 'MAPK': [93, 290, 1279, 1743], 'kinases-3,': [94, 291], '-6,': [95, 292], 'SAPK/ERK-kinase-1.': [97, 294], 'Although': [98, 295, 3893], 'many': [99, 296], 'that': [103, 135, 172, 300, 332, 369, 399, 887, 2158, 2179, 3212, 3721, 3841], 'can': [106, 142, 178, 303, 339, 375, 901, 991, 1100, 1192, 1244, 1273, 1318, 1423, 1770, 3691, 3842, 4063, 4076], 'also': [107, 304, 722, 992, 1074, 1193, 3080, 3320, 3904], 'inhibit': [108, 143, 305, 340, 2205], 'cycle': [110, 121, 145, 166, 190, 307, 318, 342, 363, 387, 2166, 2207, 2447, 2466, 2524, 2615, 3251, 3525, 3798, 4257, 4371], 'progression,': [111, 308, 2167], 'a': [112, 128, 150, 159, 309, 325, 347, 356, 543, 616, 740, 874, 1285, 1328, 1731, 1739, 2161, 2276, 2295, 2452, 2702, 2788, 2832, 2858, 3109, 3535, 3717, 3747, 3905, 4088, 4268, 4299, 4310], 'clear-cut': [113, 310], 'role': [114, 161, 311, 358, 3804], 'for': [115, 162, 312, 359, 793, 802, 986, 2224, 2373, 2393, 2410, 2431, 2464, 2527, 2530, 2610, 2846, 3060, 3074, 3171, 3737, 3900, 3998, 4004, 4010, 4016, 4034, 4084, 4087, 4254, 4270], 'has': [123, 320, 1324, 4037], 'not': [124, 138, 321, 335, 1284, 2099, 2131, 2204, 2440, 2701, 3136, 3759, 3779, 3793], 'been': [125, 322, 486, 869, 1075, 1325, 2132, 4038], 'established.': [126, 323], 'Using': [127, 324], 'quantitative': [129, 326, 2139], 'microinjection': [130, 327, 2140, 2279], 'approach,': [131, 328], 'we': [132, 329, 2137, 2156, 2177, 3519, 3814, 4259], 'show': [133, 330], 'here': [134, 331], 'Cdc42Hs,': [136, 333, 2982, 4298], 'but': [137, 334, 3758], 'Rac1': [139, 177, 187, 336, 374, 384, 1767, 1785, 2127, 2151, 2190, 2983], 'RhoA,': [141, 338], 'progression': [146, 191, 343, 388, 476, 2208, 2448, 3299, 3526], 'G1/S': [148, 345, 2172, 2450, 2624, 3298, 3385, 3417, 3714, 3812], 'through': [149, 346, 3324], 'mechanism': [151, 348], 'requiring': [152, 349], 'activation': [153, 350, 797, 1107, 1778, 1796, 2106, 2152, 2436, 2605, 3267, 3529, 3634, 3647, 3657, 3761, 3790, 3806, 4071, 4086, 4249], 'p38.': [155, 352, 994, 2111, 2154], 'These': [156, 353], 'results': [157, 170, 354, 367, 1793, 3127, 3630], 'suggest': [158, 171, 355, 368, 873], 'novel': [160, 357], 'inhibition.': [167, 364], 'Furthermore,': [168, 365], 'these': [169, 366, 539, 611, 889, 1957], 'although': [173, 370, 1281, 1430, 2194], 'both': [174, 371, 651, 1246, 1275, 2680, 4273], 'p38in': [180, 377, 3844], 'situ,': [181, 378], 'effects': [183, 380, 3522], 'on': [188, 385, 2214, 2522, 3249, 3416, 3523], 'are,': [192, 389], 'fact,': [194, 391], 'quite': [195, 392], 'distinct.': [196, 393], 'Protein': [394], 'signal': [396], 'transduction': [397], 'pathways': [398, 540, 612, 647, 737, 1959, 1973, 2122], 'employ': [400], 'members': [401, 1563], '(ERK)': [407], '1The': [408], 'abbreviations': [409], 'used': [410, 2138, 2855, 4079], 'are:': [411], 'ERK,': [412], 'kinase;': [415, 433, 439, 444, 454, 458, 463, 468, 473], 'BrdUrd,': [416], 'bromodeoxyuridine;': [417], 'CHOP,': [418], 'element': [421], 'binding': [422, 1783, 1792, 4036], 'protein;': [424], 'GADD,': [425], 'damage;': [429], 'GCK,': [430, 2980, 3770], 'germinal': [431, 1410], 'center': [432, 1411], 'HA,': [434], 'hemagglutinin;': [435], 'MAPK,': [436], 'MAPKKK,': [440], 'MAPK-kinase-kinase;': [441], 'MEK,': [442], 'MAPK/ERK': [443, 553], 'MEKK,': [445], 'MEK-kinase;': [446], 'MKK,': [447], 'MAPK-kinase': [448], '(equivalent': [449], 'to': [450, 724, 1788, 1963, 1981, 2141, 2143, 2196, 2311, 2383, 2694, 3086, 3149, 3233, 3273, 3716, 3795, 3819, 4040, 4080, 4246, 4283], 'MEK);': [451], 'PAK,': [452], 'p21-activated': [453, 1406], 'SAPK,': [455, 2968, 3474], 'SAPKK,': [459], 'SAPK-kinase;': [460], 'SEK,': [461], 'SAPK/ERK': [462], 'SPRK,': [464], 'SH3': [465, 1095], 'domain-containing,': [466, 1096], 'proline-rich': [467, 1097], 'TAK,': [469], 'factor-β-activated': [472, 1315, 1331], 'tpl,': [474], 'locus;': [477], 'wt,': [478], 'wild-type.': [479], '/mitogen-activated': [480], '(MAPK)': [483], 'have': [485, 868, 1073, 1561, 1967, 2130], 'remarkably': [487], 'conserved': [488], 'evolution': [490], '(1Kyriakis': [491, 561, 670, 752, 812, 1580, 3178, 3434, 3549], 'J.M.': [492, 512, 562, 582, 671, 691, 753, 773, 813, 833, 922, 1117, 1172, 1216, 1295, 1452, 1581, 1601, 2078, 3179, 3199, 3435, 3455, 3550, 3570, 3597, 3674, 3922, 4105, 4229], 'Avruch': [493, 513, 563, 583, 672, 692, 754, 774, 814, 834, 919, 1173, 1443, 1582, 1602, 3180, 3200, 3341, 3436, 3456, 3551, 3571, 3588, 3665, 3919, 4102], 'J.': [494, 495, 514, 564, 565, 584, 673, 674, 693, 755, 756, 775, 815, 816, 835, 920, 944, 963, 971, 1007, 1015, 1028, 1034, 1049, 1143, 1174, 1175, 1263, 1388, 1444, 1470, 1489, 1493, 1500, 1519, 1530, 1583, 1584, 1603, 1630, 1634, 1641, 1805, 1824, 1828, 1835, 1854, 1865, 2014, 2039, 3181, 3182, 3201, 3342, 3365, 3437, 3438, 3457, 3552, 3553, 3572, 3589, 3613, 3666, 3698, 3852, 3858, 3873, 3920, 3937, 3943, 3958, 4103, 4119, 4125, 4140, 4165, 4190], 'Biol.': [496, 566, 675, 757, 817, 945, 1060, 1144, 1176, 1389, 1471, 1501, 1531, 1585, 1642, 1806, 1836, 1866, 2045, 3183, 3439, 3554, 3614, 3884, 3969, 4151, 4196], 'Chem.': [497, 567, 676, 758, 818, 946, 1145, 1177, 1390, 1472, 1502, 1532, 1586, 1643, 1807, 1837, 1867, 3184, 3440, 3555, 3615], '1996;': [498, 516, 568, 586, 677, 695, 759, 777, 819, 837, 850, 973, 1017, 1061, 1146, 1178, 1264, 1391, 1587, 1605, 2046, 2086, 3185, 3203, 3441, 3459, 3556, 3574, 3885, 3970, 4152, 4197, 4237], '271:': [499, 569, 678, 760, 820, 1147, 1179, 1392, 1588, 3186, 3442, 3557], '24313-24316Abstract': [500, 570, 679, 761, 821, 1589, 3187, 3443, 3558], 'Full': [501, 503, 530, 571, 573, 600, 632, 680, 682, 709, 762, 764, 822, 824, 950, 952, 1149, 1151, 1181, 1183, 1394, 1396, 1476, 1478, 1506, 1508, 1536, 1538, 1590, 1592, 1619, 1647, 1649, 1699, 1721, 1751, 1811, 1813, 1841, 1843, 1871, 1873, 1901, 1923, 2049, 2051, 2914, 2944, 3188, 3190, 3283, 3444, 3446, 3559, 3561, 3619, 4200, 4202, 4379], 'Text': [502, 504, 531, 572, 574, 601, 633, 681, 683, 710, 763, 765, 823, 825, 951, 953, 1150, 1152, 1182, 1184, 1395, 1397, 1477, 1479, 1507, 1509, 1537, 1539, 1591, 1593, 1620, 1648, 1650, 1700, 1722, 1752, 1812, 1814, 1842, 1844, 1872, 1874, 1902, 1924, 2050, 2052, 2915, 2945, 3189, 3191, 3284, 3445, 3447, 3560, 3562, 3620, 4201, 4203, 4380], 'PDF': [505, 532, 575, 602, 634, 684, 711, 766, 826, 954, 1153, 1185, 1398, 1480, 1510, 1540, 1594, 1621, 1651, 1701, 1723, 1753, 1815, 1845, 1875, 1903, 1925, 2053, 2916, 2946, 3192, 3285, 3448, 3563, 3621, 4204, 4381], 'PubMed': [506, 519, 533, 576, 589, 603, 635, 685, 698, 712, 767, 780, 827, 840, 853, 929, 955, 976, 1020, 1043, 1064, 1128, 1154, 1186, 1227, 1267, 1306, 1359, 1399, 1457, 1481, 1511, 1541, 1595, 1608, 1622, 1652, 1674, 1702, 1754, 1816, 1846, 1876, 1904, 1944, 2023, 2054, 2089, 2917, 2947, 3193, 3206, 3286, 3353, 3374, 3399, 3449, 3462, 3564, 3577, 3602, 3622, 3679, 3867, 3888, 3929, 3952, 3973, 4112, 4134, 4155, 4174, 4205, 4240, 4341, 4382], 'Scopus': [507, 520, 534, 577, 590, 604, 636, 686, 699, 713, 768, 781, 828, 841, 854, 930, 956, 977, 1021, 1044, 1065, 1129, 1155, 1187, 1228, 1268, 1307, 1360, 1400, 1458, 1482, 1512, 1542, 1596, 1609, 1623, 1653, 1675, 1703, 1724, 1755, 1817, 1847, 1877, 1905, 1926, 1945, 2024, 2055, 2090, 2918, 2948, 3194, 3207, 3287, 3354, 3375, 3400, 3450, 3463, 3565, 3578, 3603, 3680, 3868, 3889, 3930, 3953, 3974, 4113, 4135, 4156, 4175, 4206, 4241, 4342, 4383], '(1025)': [508, 578, 687, 769, 829, 1597, 3195, 3451, 3566], 'Google': [509, 522, 536, 579, 592, 606, 638, 688, 701, 715, 770, 783, 830, 843, 856, 932, 958, 979, 1023, 1046, 1067, 1131, 1157, 1189, 1230, 1270, 1309, 1362, 1402, 1460, 1484, 1514, 1544, 1598, 1611, 1625, 1655, 1677, 1705, 1726, 1757, 1819, 1849, 1879, 1907, 1928, 1947, 2026, 2057, 2092, 2920, 2950, 3196, 3209, 3289, 3356, 3377, 3402, 3452, 3465, 3567, 3580, 3605, 3623, 3682, 3870, 3891, 3932, 3955, 3976, 4115, 4137, 4158, 4177, 4208, 4243, 4344, 4385], 'Scholar,': [510, 523, 580, 593, 689, 702, 771, 831, 844, 933, 959, 1024, 1047, 1132, 1158, 1363, 1461, 1485, 1515, 1599, 1612, 1626, 1656, 1678, 1706, 1820, 1850, 1880, 1908, 1929, 2027, 2058, 2341, 2765, 3197, 3357, 3453, 3568, 3581, 3606, 3871, 3933, 3956, 4138, 4159, 4178, 4209, 4386], '2Kyriakis': [511, 581, 690, 772, 832, 1600, 3198, 3454, 3569], 'BioEssays.': [515, 585, 694, 776, 836, 1604, 3202, 3458, 3573], '18:': [517, 587, 696, 778, 838, 1606, 3204, 3460, 3575], '567-577Crossref': [518, 588, 697, 779, 839, 1607, 3205, 3461, 3576], '(661)': [521, 591, 700, 782, 842, 1610, 3208, 3464, 3579], '3Herskowitz': [524, 594], 'I.': [525, 595, 627, 910, 1348, 1442, 3587, 3664, 3910, 4093, 4374], 'Cell.': [526, 596, 628, 705, 1059, 1615, 1695, 1717, 1747, 1897, 1919, 2910, 2940, 3279, 3883, 3968, 4150, 4375], '1995;': [527, 597, 629, 706, 947, 1040, 1356, 1454, 1473, 1503, 1533, 1616, 1644, 1671, 1696, 1718, 1748, 1808, 1838, 1868, 1898, 1920, 2020, 3280, 3350, 3371, 3599, 3676, 3864, 3949, 4131, 4171, 4376, 4401], '80:': [528, 598, 630, 707, 1617, 1719, 1749, 1921, 3281, 4377], '187-197Abstract': [529, 599, 631, 4378], '(865)': [535, 605, 637, 4384], 'Scholar).': [537, 607, 639, 716, 784, 857, 980, 1068, 1190, 1231, 1271, 1310, 1403, 1545, 1727, 1758, 1948, 2093, 2293, 2356, 2780, 2921, 2951, 3290, 3378, 3403, 3466, 3624, 3683, 3892, 3977, 4244, 4345], 'Typically': [538], 'consist': [541], 'three-tiered': [544], 'core': [545, 1573], 'kinases': [548, 554, 720, 1083, 1407, 1575, 3243], 'wherein': [549, 4029], 'MAPK-kinase-kinases': [550], '(MAPKKKs)': [551], '(MEKs),': [555], 'which,': [556, 3542], 'ERKs': [560], 'simple': [609], 'eukaryotes,': [610, 645], 'are': [613, 648, 729, 791, 984, 1000, 1435, 2553, 2627, 3423, 3837, 3897], 'activated': [614, 649, 738, 3321, 3425], 'by': [615, 650, 739, 749, 1201, 2126, 2184, 2221, 2254, 2321, 2710, 2742, 2793, 2801, 2857, 2880, 2886, 2926, 2957, 2999, 3006, 3035, 3051, 3072, 3144, 3263, 3322, 3426], 'variety': [617], 'stresses,': [619], 'nutrient': [621], 'withdrawal': [622, 1985, 2223, 3001], 'osmotic': [624], 'shock': [625], '(3Herskowitz': [626, 4373], 'mammals': [641], 'other': [643, 3241], 'multicellular': [644], 'ERK/MAPK': [646], 'stresses': [653, 745], 'more': [655], 'complex': [656, 875], 'physiologic': [657], 'mitogens,': [661], 'developmental': [662], 'cues,': [663], 'neurotransmitters,': [664], 'vasoactive': [665], 'peptides,': [666], '4Marshall': [703, 1613], 'C.J.': [704, 1614, 1746, 3278], '179-185Abstract': [708, 1618, 1750, 3282], '(4236)': [714, 1624, 1756, 3288], 'The': [717, 858, 2246, 2781, 2796, 2864, 3138, 3229], '(SAPKs,': [721], 'referred': [723], 'JNKs)': [726], 'ERK': [731, 1577], 'components': [732, 860, 3817], 'mammalian': [735, 1414, 1559, 1761, 3536, 3839], 'broad': [741], 'array': [742], 'Once': [785], 'activated,': [786], 'SAPKs': [788, 864, 904, 2109, 3422], 'responsible': [792], 'phosphorylation': [795], 'necessary': [801, 2609, 4253], 'stress': [804, 2897, 3825], 'c-Jun,': [807], 'ATF2,': [808], 'CHOP': [811], '5Wang': [845], 'X.': [846], 'Ron': [847], 'D.': [848, 1257, 2937], 'Science.': [849, 1039, 1355, 2019, 3863, 3948, 4130, 4170], '272:': [851], '1347-1349Crossref': [852], '(743)': [855], 'upstream': [861, 1206, 1333, 1569, 1733, 3821], 'which': [867, 2000, 3475, 3754], 'identified': [870, 1562, 3071], 'thus': [871, 4077], 'far': [872], 'cell-': [876], 'stimulus-dependent': [878], 'consistent': [880], 'with': [881, 2266, 2300, 2305, 2379, 2458, 2543, 2670, 2731, 2787, 2814, 2901, 3015, 3066, 3082, 3118, 3121, 3167, 3240, 3652, 3720, 3740, 3769, 3783, 4262, 4267], 'diversity': [883], 'pathways.': [890, 1776], 'Several': [891], 'chromatographically': [892], 'distinct': [893], 'MEKs,': [894], 'SEK1/MKK4,': [896], 'SAPK-kinase': [897], '(SAPKK)4,': [898], 'SAPKK5': [900, 983], 'situ': [906, 1322, 3845], 'andin': [907], 'vitro.': [908], '(6Sánchez': [909, 3909, 4092], 'Hughes': [911, 3911, 4094], 'R.T.': [912, 3912, 4095], 'Mayer': [913, 3913, 4096], 'B.J.': [914, 3914, 4097], 'Yee': [915, 3915, 4098], 'K.': [916, 1162, 1340, 1342, 1346, 1354, 1369, 1373, 1377, 1383, 2031, 3334, 3916, 4099, 4182, 4318], 'Woodgett': [917, 1120, 1219, 1298, 1447, 2042, 3592, 3669, 3917, 4100, 4193], 'J.R.': [918, 1121, 1220, 1299, 1448, 1665, 2043, 3593, 3670, 3918, 4101, 4194, 4395], 'Kyriakis': [921, 1116, 1171, 1215, 1294, 1451, 2038, 2077, 3596, 3673, 3921, 4104, 4189, 4228], 'Zon': [923, 1118, 1169, 1217, 1296, 1445, 2036, 2075, 3590, 3667, 3923, 4106, 4187, 4226], 'L.I.': [924, 1119, 1218, 1297, 1446, 2037, 2076, 3591, 3668, 3924, 4107, 4188, 4227], 'Nature.': [925, 1124, 1223, 1302, 1453, 1670, 1940, 2085, 3370, 3395, 3598, 3675, 3925, 4108, 4236, 4400], '1994;': [926, 1125, 1224, 1303, 1941, 3616, 3926, 4109], '372:': [927, 1126, 1225, 1304, 3927, 4110], '794-798Crossref': [928, 3928, 4111], '(916)': [931, 3931, 4114], '7Moriguchi': [934], 'T.': [935, 1030, 1053, 1113, 1212, 1291, 1350, 1365, 1375, 1450, 1692, 1894, 1933, 3595, 3672, 3854, 3877, 3939, 3962, 4121, 4144, 4328], 'Kawasaki': [936], 'H.': [937, 1344, 1381, 1686, 1888, 1935, 2345, 2769], 'Matsuda': [938], 'S.': [939, 1140, 1166, 1168, 1463, 1487, 1529, 1628, 1798, 1822, 1864, 2070, 3348, 3539, 4221, 4314, 4336], 'Gotoh': [940, 1370], 'Y.': [941, 1371, 1379], 'Nishida': [942, 1351, 1384], 'E.': [943, 1352, 1385, 1931, 2033, 2074, 4184, 4225], '270:': [948, 1357, 1474, 1504, 1534, 1645, 1809, 1839, 1869, 2021, 4172], '12969-12972Abstract': [949], '(123)': [957], '8Meier': [960], 'R.': [961, 1005, 2062, 2282, 2330, 2754, 4213], 'Rouse': [962, 1006], 'Cuenda': [964, 1008], 'A.': [965, 967, 1009, 1011, 1160, 1251, 1517, 1667, 1708, 1710, 1714, 1852, 1910, 1912, 1916, 2080, 2686, 2909, 2939, 3336, 3349, 3390, 4231, 4337, 4397], 'Nebreda': [966, 1010], 'Cohen': [968, 1012], 'P.': [969, 1013, 1136, 1164, 1521, 1688, 1856, 1890, 3608], 'Eur.': [970, 1014], 'Biochem.': [972, 1016], '236:': [974, 1018], '796-805Crossref': [975, 1019], '(112)': [978, 1022], 'SAPKK4': [981], 'specific': [985, 1001, 2114, 3170, 3899], 'SAPKs,': [988, 2193], 'whereas': [989], 'SEK1': [990, 1109, 1247, 1282, 2971, 3836, 3902, 4025, 4059], 'By': [995, 4019], 'contrast,': [996, 4020], 'MKK3': [997, 2952, 3894, 4027, 4061], 'MKK6': [999, 1338, 2954, 3896, 3985], 'activators': [1003], '(8Meier': [1004], '9Dérijard': [1025, 3934], 'B.': [1026, 1055, 1465, 1663, 1800, 2066, 3850, 3879, 3935, 3964, 4117, 4146, 4217, 4393], 'Raingeaud': [1027, 2013, 3851, 3936, 4118, 4164], 'Barrett': [1029, 1052, 3853, 3876, 3938, 3961, 4120, 4143], 'Wu': [1031, 3855, 3940, 4122], 'L.-H.': [1032, 3856, 3941, 4123], 'Han': [1033, 1488, 1629, 1823, 3857, 3942, 4124], 'Ulevitch': [1035, 1496, 1637, 1831, 3859, 3944, 4126], 'R.J.': [1036, 1038, 1057, 1467, 1497, 1638, 1802, 1832, 2016, 3860, 3862, 3881, 3945, 3947, 3966, 4127, 4129, 4148, 4167], 'Davis': [1037, 1056, 1466, 1801, 2015, 3861, 3880, 3946, 3965, 4128, 4147, 4166], '267:': [1041, 3865, 3950, 4132], '682-685Crossref': [1042, 3866, 3951, 4133], '(1413)': [1045, 3869, 3954, 4136], '10Raingeaud': [1048, 3872, 3957, 4139], 'Whitmarsh': [1050, 3874, 3959, 4141], 'A.J.': [1051, 2907, 2931, 3875, 3960, 4142], 'Dérijard': [1054, 1464, 1799, 3878, 3963, 4145], 'Mol.': [1058, 3882, 3967, 4149], '16:': [1062, 3886, 3971, 4153], '1247-1255Crossref': [1063, 3887, 3972, 4154], '(1147)': [1066, 3890, 3975, 4157], 'Four': [1069], 'families': [1070], 'MAPKKKs': [1072], 'implicated': [1076, 1326, 1968], 'SAPK': [1078, 1103, 1277, 1426, 1775, 1970, 2119, 2438, 2501, 3478, 3490, 3629, 3633, 3649, 3760, 3780, 3789, 3907], 'regulation.': [1081], 'MEK': [1082], '(MEKKs)': [1084], '1': [1085], '2,': [1087], 'mixed': [1092], 'lineage': [1093], '(SPRK),': [1099], 'via': [1105, 2451], 'direct': [1106, 1782], '(11Yan': [1110, 1209, 1288], 'M.': [1111, 1210, 1289, 1387, 1523, 1682, 1716, 1858, 1884, 1918, 2012, 2060, 2284, 2332, 2347, 2756, 2771, 3699, 4163, 4211], 'Dai': [1112, 1211, 1290], 'Deak': [1114, 1213, 1292], 'J.C.': [1115, 1214, 1293], 'Templeton': [1122, 1221, 1300], 'D.J.': [1123, 1222, 1301], '798-800Crossref': [1127, 1226, 1305], '(658)': [1130, 1229, 1308], '12Blank': [1133], 'J.L.': [1134], 'Gerwins': [1135], 'Elliott': [1137], 'E.M.': [1138], 'Sather': [1139], 'Johnson': [1141, 4325], 'G.L.': [1142], '5361-5368Abstract': [1148], '(207)': [1156], '13Rana': [1159], 'Gallo': [1161], 'Godowski': [1163], 'Hirai': [1165], 'Ohno': [1167], 'L.': [1170, 1939], '19025-19028Abstract': [1180], '(206)': [1188], 'MEKK2': [1191], 'mitogenic': [1196, 3260], 'MAPK/ERK1': [1197], 'directly': [1202, 2711], 'phosphorylating': [1203], 'ERK1/2': [1205], 'activator': [1207, 3908], 'MEK1': [1208, 1249], 'Tpl-2': [1232], 'rat': [1234, 2803], 'homolog': [1235, 3537, 4312], 'human': [1238, 2962, 4311], 'cot': [1239], 'proto-oncogene': [1240], 'product,': [1241], 'like': [1242], 'MEKK2,': [1243], '(14Salmerón': [1250], 'Ahmad': [1252], 'T.B.': [1253, 3367], 'Carlile': [1254], 'G.W.': [1255], 'Pappin': [1256], 'Narsimhan': [1258], 'R.P.': [1259], 'Ley': [1260], 'S.C.': [1261], 'EMBO': [1262], '15:': [1265], '817-826Crossref': [1266], '(269)': [1269], 'MEKK3': [1272, 1286], 'pathways,': [1280, 1429, 1999], 'is': [1283, 1730, 1960, 2160, 2182, 2608, 2682, 3146, 3254, 3271, 3319, 3432, 3534, 3546, 3650, 3767, 3774, 3781, 3903, 4309], 'substrate': [1287], 'addition,': [1312, 2176], 'kinase-1': [1316], '(TAK1)': [1317], 'MAPKKK': [1332, 1740], 'SEK1,': [1335, 2545, 3982, 3999], 'MKK3,': [1336, 2546, 2969, 3753, 3833, 3983, 4005], '(15Yamaguchi': [1339], 'Shirakabe': [1341, 1376], 'Shibuya': [1343, 1380], 'Irie': [1345, 1372], 'Oishi': [1347], 'Taniguchi': [1349], 'Matsumoto': [1353, 1382], '2008-2011Crossref': [1358], '(1175)': [1361], '16Moriguchi': [1364], 'Kuroyanagi': [1366], 'N.': [1367, 1690, 1892], 'Yamaguchi': [1368], 'Kano': [1374], 'Muro': [1378], 'Hagiwara': [1386], '13675-13679Abstract': [1393], '(406)': [1401], 'Finally,': [1404], '(PAKs)': [1408], '(GCK),': [1413], 'homologs': [1415], 'Saccharomyces': [1417], 'cerevisiae': [1418, 3540, 4315], 'STE20': [1419], 'SPS1,': [1421], 'respectively,': [1422], 'their': [1431], 'mechanisms': [1432, 3325], 'action': [1434], 'unclear': [1436], '(17Pombo': [1437, 3659], 'C.M.': [1438, 3583, 3660], 'Kehrl': [1439, 3584, 3611, 3661], 'J.H.': [1440, 3585, 3612, 3662], 'Sánchez': [1441, 3586, 3663], 'Force': [1449, 3594, 3671], '377:': [1455, 3372, 3600, 3677], '750-754Crossref': [1456, 3601, 3678], '(204)': [1459, 3604, 3681], '18Bagrodia': [1462], 'Cerione': [1468, 1803, 4329], 'R.A.': [1469, 1804, 4330], '27995-27998Abstract': [1475, 1810], '(598)': [1483, 1818], '19Zhang': [1486, 1627, 1821], 'Sells': [1490, 1631, 1825], 'M.A.': [1491, 1632, 1826], 'Chernoff': [1492, 1633, 1827], 'Knaus': [1494, 1635, 1829], 'U.G.': [1495, 1636, 1830], 'Bokoch': [1498, 1639, 1833], 'G.M.': [1499, 1640, 1834], '23934-23936Abstract': [1505, 1646, 1840], '(651)': [1513, 1654, 1848], '20Polverino': [1516, 1851], 'Frost': [1518, 1853], 'Yang': [1520, 1855], 'Hutchinson': [1522, 1857], 'Neiman': [1524, 1859], 'A.M.': [1525, 1860], 'Cobb': [1526, 1861], 'M.H.': [1527, 1862], 'Marcus': [1528, 1863], '26067-26070Abstract': [1535, 1870], '(88)': [1543, 1878], 'Genetic': [1546], 'epistasis': [1547], 'studies': [1548], 'yeast': [1550, 4353], 'biochemical': [1554, 2201], 'transfection': [1556], 'experiments': [1557, 2420], 'employing': [1558], 'cells': [1560, 2169, 2211, 2235, 2248, 2297, 2479, 2541, 2569, 2641, 2668, 2822, 2827, 2839, 3056, 3119, 3134, 3166, 3215, 3226, 3235, 3276, 3303, 3495, 3709, 3738], 'Ras': [1566, 1729], 'superfamily': [1567], 'elements': [1570, 2185], 'regulating': [1571], 'cascades': [1579, 3827], '21Simon': [1657, 4387], 'M.-N.': [1658, 4388], 'De': [1659, 4389], 'Virgilio': [1660, 4390], 'C.': [1661, 4391], 'Souza': [1662, 4392], 'Pringle': [1664, 4394], 'Abo': [1666, 1713, 1915, 4396], 'Reed': [1668, 4398], 'S.I.': [1669, 4399], '376:': [1672, 4402], '702-705Crossref': [1673], '(181)': [1676], '22Coso': [1679, 1881], 'O.A.': [1680, 1882], 'Chiariello': [1681, 1883], 'Yu': [1683, 1885], 'J.-C.': [1684, 1886], 'Teramoto': [1685, 1887], 'Crespo': [1687, 1889], 'Xu': [1689, 1891], 'Miki': [1691, 1893], 'Gutkind': [1693, 1895], 'J.S.': [1694, 1896], '81:': [1697, 1899], '1137-1146Abstract': [1698, 1900], '(1567)': [1704, 1906], '23Minden': [1707, 1909], 'Lin': [1709, 1911, 2063, 4214], 'Claret': [1711, 1913], 'F.-X.': [1712, 1914], 'Karin': [1715, 1917], '1147-1157Abstract': [1720, 1922], '(1446)': [1725, 1927], 'Thus,': [1728, 3788], 'critical': [1732, 4033], 'regulator': [1734], 'Raf1': [1737], 'kinase,': [1738, 2398, 3025], '(4Marshall': [1745, 3277], 'Similarly,': [1759], 'cells,': [1762, 1988, 3312], 'This': [1777, 1791, 4358], 'may': [1779, 2098], 'involve': [1780], 'PAKs.': [1790], 'PAK': [1795], '(18Bagrodia': [1797], '24Manser': [1930], 'Leung': [1932], 'Salihuddin': [1934], 'Zhao': [1936], 'Z.-s.': [1937], 'Lim': [1938], '367:': [1942], '40-46Crossref': [1943], '(1300)': [1946], 'A': [1949], 'complete': [1950], 'picture': [1951], 'biological': [1954, 2103, 2115, 2146, 4073, 4090], 'functions': [1955], 'only': [1961, 2102, 3500], 'beginning': [1962], 'emerge.': [1964], 'Recent': [1965], 'data': [1966], 'induction': [1976, 2095], 'apoptosis': [1978, 2097], 'nerve': [1982], 'PC-12': [1987], 'heat': [1992], 'shock,': [1993], 'chemotherapeutics': [1995], '(cis-platinum),': [1996], 'stimulate': [2001], 'generation': [2003], 'ceramide': [2005], 'from': [2006, 2251, 2366, 2961, 2975, 2989, 3409, 3986], 'membrane': [2007], 'sphingomyelin': [2008], '(25Xia': [2009], 'Z.': [2010, 2082, 4161, 4233], 'Dickens': [2011, 4162], 'Greenberg': [2017, 4168], 'M.E.': [2018, 4169], '1326-1331Crossref': [2022, 4173], '(5036)': [2025, 4176], '26Zanke': [2028, 4179], 'B.W.': [2029, 4180], 'Boudreau': [2030, 4181], 'Rubie': [2032, 4183], 'Tibbles': [2034, 4185], 'L.A.': [2035, 4186], 'Liu': [2040, 4191], 'F.-F.': [2041, 4192], 'Curr.': [2044, 4195], '6:': [2047, 4198], '606-613Abstract': [2048, 4199], '(438)': [2056, 4207], '27Verheij': [2059, 4210], 'Bose': [2061, 4212], 'X.H.': [2064, 4215], 'Yao': [2065, 4216], 'Jarvis': [2067, 4218], 'W.D.': [2068, 4219], 'Grant': [2069, 4220], 'Birrer': [2071, 4222], 'M.J.': [2072, 4223, 4322], 'Szabo': [2073, 4224], 'Haimovitz-Friedman': [2079, 4230], 'Fuks': [2081, 4232], 'Kolesnick': [2083, 4234], 'R.N.': [2084, 4235], '380:': [2087, 4238], '75-79Crossref': [2088, 4239], '(1716)': [2091, 4242], 'However,': [2094], 'be': [2100, 4078], 'consequence': [2104], 'Moreover,': [2112], 'roles': [2116], 'mediated': [2125, 2183], 'elucidated.': [2133], 'this': [2135, 2180, 2228, 3269, 3517, 3771], 'study,': [2136], 'begin': [2142], 'characterize': [2144], 'consequences': [2147], 'Here': [2155], 'report': [2157], 'potent': [2162, 3632], 'inhibitor': [2163], 'arresting': [2168], 'transition': [2173, 2691, 3386, 3418, 3715], 'point.': [2174], 'demonstrate': [2178], 'inhibition': [2181, 2612, 2622, 3112, 3139, 3502, 3712, 3810], 'able': [2195], 'induce': [2197], 'characteristic': [2198], 'cellular': [2199, 2327], 'responses,': [2202], 'do': [2203], 'significantly.': [2209], 'NIH-3T3': [2210, 2994, 3275, 3708], 'were': [2212, 2249, 2261, 2298, 2358, 2377, 2456, 2729, 2812, 2828, 2899, 2955, 2973, 2987, 2996, 3010, 3057, 3070, 3079, 3128], 'grown': [2213], 'glass': [2215], 'coverslips': [2216, 2728], 'synchronized': [2218, 3003], 'G0': [2220], 'serum': [2222, 2252, 2259, 2367, 3000, 3007], '24': [2225, 2242, 3042], 'h.': [2226], 'After': [2227, 3041], 'period,': [2229], 'less': [2230], 'than': [2231, 3222], '1%': [2232], 'incorporated': [2236, 2797], 'bromodeoxyuridine': [2237], '(BrdUrd)': [2238], 'during': [2239], 'an': [2240, 2306, 3168, 3255], 'additional': [2241], 'h': [2243], 'incubation.': [2245], 'arrested': [2247], 'released': [2250], 'starvation': [2253, 2368], 'readdition': [2255], '10%': [2257], 'calf': [2258], 'microinjected': [2262, 2299, 3011, 3160, 3410, 3987], 'early': [2264, 3013], 'G1': [2265, 2442, 2531, 3005, 3014, 3237, 3772, 4369], 'expression': [2267, 2518, 2705, 3016, 3044, 3293, 3471, 4021, 4294], 'vectors': [2268, 3017], 'harboring': [2269], 'HA-tagged': [2271, 2544, 3019], 'FLAG-tagged': [2273], 'cDNAs,': [2274], 'using': [2275, 3130], 'Zeiss': [2277], 'automated': [2278], 'system': [2280], '(28Pepperkok': [2281, 2329, 2753], 'Pagano': [2283, 2331, 2346, 2755, 2770], 'Cell': [2285, 2333, 2348, 2757, 2772], 'Cycle:': [2286, 2334, 2349, 2758, 2773], 'Materials': [2287, 2335, 2350, 2759, 2774], 'Methods.in:': [2289, 2337, 2352, 2761, 2776], 'Springer-Verlag,': [2290, 2338, 2353, 2762, 2777], 'Berlin1995:': [2291, 2339, 2354, 2763, 2778], '75-86Google': [2292, 2340, 2764], 'As': [2294], 'control,': [2296], 'empty': [2302, 2406, 2411, 2481, 2597, 2643, 3027, 3068, 3122, 3310, 3741, 4017], 'vector': [2303, 3069], 'together': [2304], 'inert': [2307], 'rabbit': [2308, 2783, 2851, 3076], 'antibody': [2309, 2735, 2745, 2805, 2853, 2862, 2889, 3169], 'marker': [2310], 'identify': [2312], 'injected': [2314, 2457, 2542, 2838, 3065, 3120, 3165, 3473, 3494, 3739], 'cells.': [2315, 3103, 3161], 'S': [2316, 2475, 2537, 2564, 2638, 2689, 2824, 3031, 3061, 3114, 3141, 3305, 3504, 3509, 3730, 3735, 3830, 3991, 3996, 4002, 4008, 4014, 4285], 'phase': [2317, 2476, 2538, 2565, 2639, 2690, 3032, 3062, 3115, 3142, 3306, 3505, 3731, 3736, 3831, 3992, 3997, 4003, 4009, 4015, 4286], 'entry': [2318, 2539, 3116, 3143, 3506, 3993, 4287], 'was': [2319, 2692, 2708, 2785, 2799, 2854, 2878, 2924, 3033, 3049, 3238, 4044, 4252], 'monitored': [2320, 3034], 'BrdUrd': [2322, 2798, 3038], '(100': [2323], 'μm)': [2324], 'incorporation': [2325, 3036], 'into': [2326, 3030, 3039, 3707], '29Cardoso': [2342, 2766], 'M.C.': [2343, 2767], 'Leonhardt': [2344, 2768], '15-28Google': [2355, 2779], 'Cells': [2357, 2371, 2455, 3009, 3064, 3078], 'fixed': [2359, 2378], 'indicated': [2362, 2460], 'time': [2363], 'after': [2364], 'release': [2365], 'described.': [2370], 'stained': [2372, 2730, 2900, 3102], 'phospho-p38': [2374], 'phospho-c-Jun': [2376], '4%': [2380], 'paraformaldehyde': [2381], 'according': [2382], "manufacturer's": [2385], 'suggestions.': [2386], 'Injected': [2387], 'concentrations': [2389], 'were:': [2390, 2480, 2570, 2642], '100': [2391], 'ng/μl': [2392, 2409, 2430], 'HA-p38,': [2394, 2870], 'HA-SAPK,': [2395], 'HA-p44MAPK,': [2396], 'HA-p70S6': [2397], 'HA-MKK3,': [2399], 'HA-MKK3-KR,': [2400, 2413], 'HA-SEK1,': [2401], 'HA-SEK1-KR,': [2402], 'HA-MKK6,': [2403], 'M2-FLAG-GCK,': [2404], 'pMT3;': [2407], '240': [2408], 'pMT3,': [2412], 'HA-SEK1-KR': [2415], 'dominant': [2418, 3749, 4066], 'negative': [2419], 'shown': [2421, 2552, 2683], 'Figs.': [2423], '1,': [2424], '3,': [2425], '4;': [2427], '80': [2429], 'GTPases.Figure': [2434], '3Strong': [2435], 'does': [2439, 3792], 'promote': [2441], 'arrest.': [2443, 2532, 3799], 'GCK': [2444, 2492, 2499, 3533, 3627, 3646, 3690, 3706, 3785], 'inhibits': [2445], 'p38-dependent': [2453], 'mechanism.': [2454], 'plasmids': [2461, 2986, 3988], 'assayed': [2463], 'progression.': [2467, 2616, 3252], 'For': [2468, 2557, 2631], 'each': [2469, 2558, 2632], 'injection': [2470, 2559, 2633, 3724], 'set,': [2471], 'ratios': [2473, 2562, 2636], 'cells/total': [2477, 2567], 'expressing': [2478, 2566, 2568, 2840, 3055], 'plasmid:': [2482, 2644], '53/85,': [2483], '67/96,': [2484], '80/117,': [2485], '53/73:': [2486], 'GCK:': [2487], '16/59,': [2488], '9/44,': [2489], '15/33,': [2490], '6/29;': [2491], 'plus': [2493, 2500, 2502, 2653, 2659], 'KR-MKK3:': [2494, 2503, 2586, 2654], '37/62,': [2495], '47/78,': [2496], '19/40,': [2497], '9/17;': [2498], '21/42,': [2504], '25/43,': [2505], '11/21,': [2506], '12/25.View': [2507], 'Large': [2508, 2719], 'Image': [2509, 2720], 'Figure': [2510, 2721], 'ViewerDownload': [2511, 2722], 'Hi-res': [2512, 2723], 'image': [2513, 2724], 'Download': [2514, 2725], '(PPT)Figure': [2515], '4Effect': [2516], 'p38-activating': [2520], 'MEKs': [2521, 3840], 'progression:': [2525], 'requirement': [2526, 4083, 4269], 'active': [2528, 3156, 3548, 4271], 'Part': [2533, 2664], 'a,': [2534], 'quantitation': [2535], 'MKK6,': [2547, 2981, 3834, 4011], 'KR-SEK1,': [2548], 'KR-MKK3.': [2550], 'Data': [2551], 'mean': [2554, 2628], '±': [2555, 2629], 'S.D.': [2556, 2630], 'set': [2560, 2634], 'MKK3:': [2571], '6/55,': [2572], '11/55,': [2573], '3/22,': [2574], '9/40,': [2575], '12/67;': [2576], 'SEK1:': [2577], '8/50,': [2578], '2/22,': [2579], '5/36,': [2580], '4/24;': [2581], 'MKK6:': [2582], '7/47,': [2583], '6/62,': [2584], '5/33;': [2585], '17/27,': [2587], '9/16,': [2588], '10/15,': [2589], '26/49,': [2590], '47/78;': [2591], 'KR-SEK1:': [2592, 2660], '45/85,': [2593], '12/23,': [2594], '12/20,': [2595], '14/33;': [2596], 'vector:': [2598], '28/47,': [2599], '27/45,': [2600], '52/66,': [2601], '76/90,': [2602], '46/67.Part': [2603], 'b,': [2604], 'p38-mediated': [2611, 4255], 'KR-MKK3': [2617, 2676, 2699, 4263, 4276], 'KR-SEK1': [2619, 4274], 'block': [2620, 3829, 4284], 'transition.': [2625], 'Shown': [2626], 'cells/expressing': [2640], '80/113,': [2645], '33/48,': [2646], '64/101;': [2647], 'p38:': [2648], '6/27;': [2649], '8/30,': [2650], '6/32;': [2651], '18/30,': [2655], '19/32,': [2656], '18/27;': [2657], '14/20,': [2661], '18/26,': [2662], '16/28.': [2663], 'C,': [2665], 'immunostaining': [2666], 'coinjected': [2669, 2782, 3075, 3768, 3782, 4260], 'HA': [2672], 'tagged': [2673, 2842], 'cDNAs.': [2677, 2843], 'Expression': [2678, 3104, 3404, 3978], 'proteins': [2681], 'panel': [2685], 'That': [2687], 'due': [2693, 3148], 'inhibitory': [2696, 3750], 'effect': [2697, 3248, 3415, 4047], 'lack': [2703, 4053], 'verified': [2709, 3050], 'staining': [2712, 2749, 2927, 3073], 'expressed': [2714, 2869, 2974, 2988, 3544], '(panel': [2717], 'B).View': [2718], '(PPT)': [2726], 'Fixed': [2727], 'anti-HA': [2732, 2849], 'mouse': [2733, 2738], 'monoclonal': [2734, 2739, 2804], 'anti-M2-FLAG': [2737], 'antibody,': [2740, 2791], 'followed': [2741, 2792, 2856, 2885], 'biotinylated': [2743, 2789, 2887], 'anti-mouse': [2744], 'streptavidin-Texas': [2747], 'Red': [2748], 'described': [2751, 2905, 2929], 'previously': [2752], 'IgG': [2784], 'detected': [2786, 2800, 2879, 2925], 'anti-rabbit': [2790, 2861, 2888], 'streptavidin-Texas-Red': [2794], 'staining.': [2795, 2863, 2895], 'anti-BrdUrd': [2802], 'anti-rat': [2807], 'fluorescein': [2808, 2902], 'isothiocyanate': [2809, 2894], 'antibody.': [2810], 'Nuclei': [2811], 'counterstained': [2813, 3081], 'Hoechst': [2815], '33258': [2816], 'dye': [2817], '(1': [2818], 'μg/ml).': [2819], 'To': [2820, 2844, 3467, 3800], 'quantitate': [2821], 'phase,': [2825], 'BrdUrd-positive': [2826], 'scored': [2829, 3058], 'blindly': [2830, 3059], 'percent': [2833], 'number': [2836], 'stain': [2845], 'following': [2848], 'staining,': [2850], 'anti-p38': [2852], '9-amino-6-chloro-2-methoxyacridine': [2859], 'conjugated': [2860], 'phosphorylated': [2865, 3174, 3220, 3487], 'portion': [2866], 'endogenous': [2872], 'protein,': [2874], 'c-Jun': [2876, 3488], 'anti-phospho-p38': [2881], 'anti-phospho-c-Jun': [2883], 'antibodies,': [2884], 'streptavidin-9-amino-6-chloro-2-methoxyacridine': [2891], 'streptavidin-fluorescein': [2893], 'Actin': [2896], 'fibers': [2898], 'phalloidin': [2903], '(30Ridley': [2906], 'Hall': [2908, 2938], '1992;': [2911, 2941], '70:': [2912, 2942], '389-400Abstract': [2913], '(3832)': [2919], 'Membrane': [2922], 'ruffling': [2923], '(31Ridley': [2930], 'Paterson': [2932], 'H.F.': [2933], 'Johnston': [2934], 'C.L.': [2935], 'Diekmann': [2936], '401-410Abstract': [2943], '(3076)': [2949], 'cloned': [2956], 'polymerase': [2958], 'chain': [2959], 'reaction': [2960], 'B': [2963], '(RAMOS)': [2965], 'cDNA.': [2966], 'p38,': [2967, 3020, 3757, 3901, 4272], 'cDNAs': [2972], 'pMT3': [2977], '(HA-tagged)': [2978], 'vector.': [2979, 2992, 3028], 'RhoA': [2985], 'pCMV5-M2-FLAG': [2991], 'Murine': [2993], 'fibroblasts': [2995], 'rendered': [2997], 'quiescent': [2998], 'readdition.': [3008], 'encoding': [3018], 'SAPK-p46βI,': [3021], 'p44-MAPK,': [3022], 'p70': [3023, 3316, 3381, 3406], 'S6': [3024, 3317, 3382, 3407], 'Entry': [3029], 'DNA.': [3040], 'h,': [3043], 'relevant': [3047], 'constructs': [3048], 'immunostaining,': [3052], 'entry.': [3063, 3832], 'IgG.': [3077], 'bisbenzimide': [3083], '(Hoechst': [3084], '33258)': [3085], 'visualize': [3087], 'all': [3088], 'nuclei': [3089], 'assess': [3091, 4081], 'any': [3092], 'abnormal': [3093], 'nuclear': [3094], 'morphology.': [3095], 'Fig.1': [3096], 'shows': [3097], 'representative': [3098], 'photomicrographs': [3099], 'resulted': [3107, 3498, 3710], 'striking': [3110], '77.5%': [3111], 'compared': [3117], 'plasmid': [3123, 3411], '(Fig.2': [3124, 3227, 3496], 'a).': [3125, 3315, 3421, 3513, 4050], 'Similar': [3126], 'obtained': [3129, 3722], 'mink': [3131], 'lung': [3132], 'Mv1Lu': [3133], '(data': [3135], 'shown).': [3137], 'likely': [3147, 3791], 'presence': [3151], 'increased': [3153, 3476], 'amounts': [3154, 3218], 'Staining': [3162], 'active,': [3173], 'form': [3175], 'Scholar)': [3210], 'revealed': [3211], 'p38-expressing': [3214], 'contained': [3216], 'greater': [3217], 'did': [3223], 'uninjected': [3225], 'b).': [3228], 'ability': [3230, 4280], 'specific,': [3239, 3651], 'having': [3244], 'little': [3245], 'no': [3247, 3413, 3653], 'p44-MAPK': [3253, 3295], 'integral': [3256], 'component': [3257], 'recruited': [3262], 'Ras,': [3264], 'constitutive': [3266], 'sufficient': [3272], 'transform': [3274], 'Not': [3291], 'surprisingly,': [3292], 'modestly': [3296], 'enhanced': [3297], '(91%': [3300], 'p44-MAPK-expressing': [3302], 'versus': [3307, 3732], '69%': [3308, 4012], 'plasmid-injected': [3311], 'Fig.': [3313, 3511, 3743, 3765], 'mitogens': [3323], 'involving': [3326], 'phosphatidylinositol': [3327], '3-kinase': [3328], 'FRAP/RAFT/TOR': [3330], '(32Weng': [3331], 'Q.-P.': [3332], 'Andrabi': [3333], 'Klippel': [3335], 'Kozlowski': [3337], 'M.T.': [3338], 'Williams': [3339], 'L.T.': [3340], 'Proc.': [3343, 4331], 'Natl.': [3344, 4332], 'Acad.': [3345, 4333], 'Sci.': [3346, 4334], 'U.': [3347, 4335], '92:': [3351], '5744-5748Crossref': [3352], '(202)': [3355], '33Brown': [3358], 'E.J.': [3359], 'Beal': [3360], 'P.A.': [3361], 'Keith': [3362], 'C.T.': [3363], 'Chen': [3364], 'Shin': [3366], 'Schreiber': [3368], 'S.L.': [3369], '441-446Crossref': [3373], '(618)': [3376], 'Inhibition': [3379], 'blocks': [3384, 3756], '(34Lane': [3387], 'H.A.': [3388], 'Fernandez': [3389], 'Lamb': [3391], 'N.J.C.': [3392], 'Thomas': [3393], 'G.': [3394, 3610], '1993;': [3396], '363:': [3397], '170-172Crossref': [3398], '(318)': [3401], 'had': [3412], 'significant': [3414, 4046], '(Fig.': [3419, 3786, 4048, 4288, 4295], 'preferentially': [3424], 'same': [3428], 'antimitogenic': [3429], 'our': [3468], 'surprise,': [3469], 'however,': [3470, 3689, 4057], 'intracellular': [3477], 'activity': [3479, 4074], 'and,': [3480], 'consequently,': [3481], 'substantially': [3482], 'elevated': [3483], 'level': [3485], '(a': [3489], 'substrate)': [3491], 'b),': [3497], 'modest': [3501], '(55%': [3507], 'phase;': [3510], 'view': [3515], 'result,': [3518], 'explored': [3520], 'strong': [3528, 3906], 'SAPKs.': [3532], 'SPS1': [3541], 'when': [3543], 'transiently,': [3545], 'constitutively': [3547], '17Pombo': [3582], '35Katz': [3607], 'Whalen': [3609], '269:': [3617], '16802-16809Abstract': [3618], 'Coexpression': [3625], 'absence': [3637], 'external': [3639], 'stimuli.': [3640], 'At': [3641, 3684], 'low': [3642], 'levels': [3643, 3686], 'expression,': [3645, 3688], 'ERK1': [3656], 'seen': [3658], 'high': [3685], 'modestly.': [3694], '2T.': [3695], 'Yuasa': [3696], 'Kyriakis,': [3700], 'manuscript': [3701], 'preparation.': [3703], 'Injection': [3704], 'degree': [3718], 'commensurate': [3719], 'upon': [3723], 'alone': [3727], '(25%': [3728], '67%': [3733], 'vector,': [3742], '3).': [3744, 3787], 'If': [3745], 'KR-MKK3,': [3746], 'kinase-dead': [3748], 'mutant': [3751, 4024], 'specifically': [3755], '(9': [3762], 'see': [3764], '4)': [3766], 'abolished': [3775], 'completely': [3776, 4277], 'whether': [3777, 4248], 'contribute': [3794], 'GCK-mediated': [3796], 'investigate': [3801], 'further': [3802], 'transition,': [3813], 'asked': [3815], 'if': [3816], 'known': [3818], 'lie': [3820], 'could': [3828], 'vitro': [3848], '(9Dérijard': [3849], 'apparently': [3898], 'HA-tagged,': [3980], 'wild-type': [3981], 'strongly': [3989], 'inhibited': [3990, 4278], '(14%': [3994], '17%': [4000], '15%': [4006], 'plasmid).': [4018], 'kinase-inactive': [4023, 4058], 'plasmids,': [4028], 'lysine': [4031], 'residue': [4032], 'ATP': [4035], 'mutated': [4039], 'arginine': [4041], '(KR': [4042], 'mutants),': [4043], 'without': [4045, 4291], '4': [4049, 4289, 4296], 'Despite': [4051], 'intrinsic': [4055], 'activity,': [4056], 'mutants': [4062], 'act': [4064], 'inhibitors': [4067], 'coexpressed': [4069], 'particular': [4089], 'function': [4091], 'Scholar,9Dérijard': [4116], '25Xia': [4160], 'Accordingly,': [4245], 'test': [4247], 'arrest,': [4258], 'KR-SEK1.': [4265], 'Consistent': [4266], 'b)': [4290], 'preventing': [4292], 'c).': [4297], 'member': [4300], 'subfamily': [4304], 'small': [4306], 'GTP-binding': [4307], 'proteins,': [4308], 'CDC42': [4316], '(36Shinjo': [4317], 'Koland': [4319], 'J.G.': [4320], 'Hart': [4321], 'Narasimhan': [4323], 'V.': [4324], 'D.I.': [4326], 'Evans': [4327], '1990;': [4338], '87:': [4339], '9853-9857Crossref': [4340], '(174)': [4343], 'Cdc42p': [4346], 'activates': [4347, 4360], 'Ste20p': [4348], 'part': [4350], 'mating': [4354], 'pheromone': [4355], 'ERKs,': [4362], 'Fus3p': [4363], 'Kss1p,': [4365], 'culminates': [4367]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2014598325', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2024-12-25T19:08:00.701466', 'created_date': '2016-06-24'}