Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2014162746', 'doi': 'https://doi.org/10.1016/s0006-291x(03)01347-0', 'title': 'A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity', 'display_name': 'A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity', 'publication_year': 2003, 'publication_date': '2003-07-22', 'ids': {'openalex': 'https://openalex.org/W2014162746', 'doi': 'https://doi.org/10.1016/s0006-291x(03)01347-0', 'mag': '2014162746', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12890487'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0006-291x(03)01347-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5108490508', 'display_name': 'Kou Miyazaki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210115246', 'display_name': 'Chiba Cancer Center', 'ror': 'https://ror.org/02120t614', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115246']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kou Miyazaki', 'raw_affiliation_strings': ['Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, 260-8717, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, 260-8717, Japan.', 'institution_ids': ['https://openalex.org/I4210115246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034252509', 'display_name': 'Toshinori Ozaki', 'orcid': 'https://orcid.org/0000-0002-1612-7394'}, 'institutions': [{'id': 'https://openalex.org/I4210115246', 'display_name': 'Chiba Cancer Center', 'ror': 'https://ror.org/02120t614', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115246']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshinori Ozaki', 'raw_affiliation_strings': ['Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan', 'institution_ids': ['https://openalex.org/I4210115246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101681096', 'display_name': 'Chiaki Kato', 'orcid': 'https://orcid.org/0009-0002-7599-0283'}, 'institutions': [{'id': 'https://openalex.org/I4210115246', 'display_name': 'Chiba Cancer Center', 'ror': 'https://ror.org/02120t614', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115246']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Chiaki Kato', 'raw_affiliation_strings': ['Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan', 'institution_ids': ['https://openalex.org/I4210115246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052475442', 'display_name': 'Takayuki Hanamoto', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210115246', 'display_name': 'Chiba Cancer Center', 'ror': 'https://ror.org/02120t614', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115246']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takayuki Hanamoto', 'raw_affiliation_strings': ['Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan', 'institution_ids': ['https://openalex.org/I4210115246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102731978', 'display_name': 'Tomoyuki Fujita', 'orcid': 'https://orcid.org/0000-0002-6795-172X'}, 'institutions': [{'id': 'https://openalex.org/I4210115246', 'display_name': 'Chiba Cancer Center', 'ror': 'https://ror.org/02120t614', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115246']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tomoyuki Fujita', 'raw_affiliation_strings': ['Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan', 'institution_ids': ['https://openalex.org/I4210115246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040947542', 'display_name': 'S Irino', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210115246', 'display_name': 'Chiba Cancer Center', 'ror': 'https://ror.org/02120t614', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115246']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shigemi Irino', 'raw_affiliation_strings': ['Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan', 'institution_ids': ['https://openalex.org/I4210115246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100739385', 'display_name': 'Kenichi Watanabe', 'orcid': 'https://orcid.org/0000-0002-5269-146X'}, 'institutions': [{'id': 'https://openalex.org/I4210115246', 'display_name': 'Chiba Cancer Center', 'ror': 'https://ror.org/02120t614', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115246']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ken-ichi Watanabe', 'raw_affiliation_strings': ['Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan', 'institution_ids': ['https://openalex.org/I4210115246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103871603', 'display_name': 'Takahito Nakagawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210115246', 'display_name': 'Chiba Cancer Center', 'ror': 'https://ror.org/02120t614', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115246']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takahito Nakagawa', 'raw_affiliation_strings': ['Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan', 'institution_ids': ['https://openalex.org/I4210115246']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5059436010', 'display_name': 'Akira Nakagawara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210115246', 'display_name': 'Chiba Cancer Center', 'ror': 'https://ror.org/02120t614', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115246']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akira Nakagawara', 'raw_affiliation_strings': ['Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan', 'institution_ids': ['https://openalex.org/I4210115246']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2770, 'currency': 'USD', 'value_usd': 2770, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.524, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 91, 'citation_normalized_percentile': {'value': 0.999911, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '308', 'issue': '1', 'first_page': '106', 'last_page': '113'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12996', 'display_name': 'Cancer Research and Treatments', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nedd4', 'display_name': 'NEDD4', 'score': 0.8143399}, {'id': 'https://openalex.org/keywords/immunoprecipitation', 'display_name': 'Immunoprecipitation', 'score': 0.71870023}, {'id': 'https://openalex.org/keywords/ww-domain', 'display_name': 'WW domain', 'score': 0.46221656}, {'id': 'https://openalex.org/keywords/hek-293-cells', 'display_name': 'HEK 293 cells', 'score': 0.43241072}], 'concepts': [{'id': 'https://openalex.org/C2777265272', 'wikidata': 'https://www.wikidata.org/wiki/Q18030005', 'display_name': 'NEDD4', 'level': 5, 'score': 0.8143399}, {'id': 'https://openalex.org/C134459356', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin ligase', 'level': 4, 'score': 0.81145096}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.7721824}, {'id': 'https://openalex.org/C71829478', 'wikidata': 'https://www.wikidata.org/wiki/Q901305', 'display_name': 'Immunoprecipitation', 'level': 3, 'score': 0.71870023}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6362851}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4984362}, {'id': 'https://openalex.org/C204491159', 'wikidata': 'https://www.wikidata.org/wiki/Q24726881', 'display_name': 'WW domain', 'level': 3, 'score': 0.46221656}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.4538589}, {'id': 'https://openalex.org/C51639874', 'wikidata': 'https://www.wikidata.org/wiki/Q167149', 'display_name': 'Plasma protein binding', 'level': 2, 'score': 0.4440743}, {'id': 'https://openalex.org/C174510640', 'wikidata': 'https://www.wikidata.org/wiki/Q489618', 'display_name': 'HEK 293 cells', 'level': 3, 'score': 0.43241072}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.36896774}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3345489}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.28128934}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.1977694}], 'mesh': [{'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008025', 'descriptor_name': 'Ligases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019556', 'descriptor_name': 'COS Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D016147', 'descriptor_name': 'Genes, Tumor Suppressor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008025', 'descriptor_name': 'Ligases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D008025', 'descriptor_name': 'Ligases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072160', 'descriptor_name': 'Tumor Protein p73', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025521', 'descriptor_name': 'Tumor Suppressor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0006-291x(03)01347-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12890487', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320320912', 'funder_display_name': 'Ministry of Education, Culture, Sports, Science and Technology', 'award_id': None}, {'funder': 'https://openalex.org/F4320322034', 'funder_display_name': 'Ministry of Health and Welfare', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1496897161', 'https://openalex.org/W1519258930', 'https://openalex.org/W1531240647', 'https://openalex.org/W1579239145', 'https://openalex.org/W1590583667', 'https://openalex.org/W1675096266', 'https://openalex.org/W1919213387', 'https://openalex.org/W1982121839', 'https://openalex.org/W1985064409', 'https://openalex.org/W1997222931', 'https://openalex.org/W1997837993', 'https://openalex.org/W1998287298', 'https://openalex.org/W2003044806', 'https://openalex.org/W2007249806', 'https://openalex.org/W2011186424', 'https://openalex.org/W2014102011', 'https://openalex.org/W2037454778', 'https://openalex.org/W2056530510', 'https://openalex.org/W2056599780', 'https://openalex.org/W2059193889', 'https://openalex.org/W2068564200', 'https://openalex.org/W2070268999', 'https://openalex.org/W2082979850', 'https://openalex.org/W2084499174', 'https://openalex.org/W2106031335', 'https://openalex.org/W2118116576', 'https://openalex.org/W2121071095', 'https://openalex.org/W2121320998', 'https://openalex.org/W2123623018', 'https://openalex.org/W2126787895', 'https://openalex.org/W2139986038', 'https://openalex.org/W2152221369', 'https://openalex.org/W2160636324', 'https://openalex.org/W2336498212', 'https://openalex.org/W2340120319'], 'related_works': ['https://openalex.org/W4246319550', 'https://openalex.org/W4239748198', 'https://openalex.org/W4238487603', 'https://openalex.org/W4237566073', 'https://openalex.org/W4232824453', 'https://openalex.org/W3205974413', 'https://openalex.org/W3104601484', 'https://openalex.org/W2138926988', 'https://openalex.org/W2077336988', 'https://openalex.org/W2015709967'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2014162746', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-14T03:44:53.643855', 'created_date': '2016-06-24'}