Protein Kinase C δ Is Essential for Etoposide-induced Apoptosis in Salivary Gland Acinar Cells

Name: Work Video:
Duration: 3 min 30 s
Mary E. Reyland; Steven M. Anderson; Angela A. Matassa; K. A. Barzen; David O. Quissell
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4097, 4114, 4129, 4142, 4154, 4170, 4175, 4211, 4219, 4239, 4260, 4268, 4355, 4376], 'response': [13, 265, 1183, 1996, 2045, 3830, 3843], 'to': [14, 58, 98, 266, 310, 350, 628, 662, 664, 939, 1184, 1410, 1479, 1537, 1741, 1750, 1997, 2031, 2046, 2105, 2110, 2313, 2360, 2400, 2405, 2901, 2939, 3014, 3089, 3100, 3212, 3222, 3339, 3374, 3377, 3440, 3618, 3794, 3819, 3825, 3831, 3844, 3856, 3864, 3991, 4040, 4104, 4215, 4274, 4297, 4343, 4392, 4462], 'etoposide': [15, 102, 156, 267, 354, 408, 3099, 3194, 3242, 3336, 3449, 3523, 3798, 4000, 4108], 'treatment': [16, 268, 1405, 2091, 3236, 3307, 3480, 3808, 4013], 'as': [17, 269, 1115, 1174, 1176, 2371, 2483, 2492, 2593, 2750, 2800, 3548, 3636, 3668, 3670, 3674, 3986, 4019], 'indicated': [18, 270, 3535, 3590], 'by': [19, 271, 540, 1416, 1703, 1989, 2252, 2323, 2396, 2521, 2589, 2648, 2675, 2782, 2875, 2911, 3033, 3061, 3073, 3147, 3179, 3303, 3369, 3418, 3442, 3545, 3629, 3988, 3996, 4021, 4234, 4323], 'alterations': [20, 272], 'cell': [22, 250, 274, 502, 1135, 1259, 1282, 1543, 1874, 2061, 2125, 2135, 2584, 3107, 3110, 3284, 3970, 4167], 'morphology,': [23, 109, 190, 275, 361, 442], 'caspase-3': [24, 132, 191, 276, 384, 443, 1990, 2730, 3191], 'activation,': [25, 192, 277, 444], 'DNA': [26, 135, 194, 278, 387, 446, 2687, 2712, 3188], 'fragmentation,': [27, 195, 279, 447, 3189], 'sustained': [28, 111, 202, 280, 363, 454], 'activation': [29, 112, 133, 203, 221, 281, 364, 385, 455, 473, 1629, 1738, 1986, 2728, 2827, 3196, 3574, 3663, 3865, 4320, 4335, 4354], 'of': [30, 36, 53, 64, 78, 91, 101, 106, 113, 119, 127, 163, 180, 204, 210, 222, 230, 243, 282, 288, 305, 316, 330, 343, 353, 358, 365, 371, 379, 415, 432, 456, 462, 474, 482, 495, 534, 631, 635, 652, 731, 859, 863, 897, 923, 945, 1113, 1118, 1128, 1263, 1269, 1322, 1331, 1486, 1495, 1623, 1630, 1638, 1701, 1739, 1877, 1886, 1987, 2036, 2073, 2092, 2101, 2118, 2129, 2269, 2427, 2507, 2566, 2577, 2598, 2603, 2616, 2651, 2669, 2707, 2716, 2729, 2787, 2893, 2931, 2935, 2942, 2950, 2986, 3036, 3039, 3057, 3068, 3080, 3098, 3182, 3197, 3202, 3216, 3220, 3237, 3249, 3266, 3273, 3306, 3312, 3325, 3346, 3358, 3383, 3409, 3423, 3435, 3448, 3453, 3460, 3472, 3490, 3494, 3499, 3519, 3527, 3559, 3575, 3582, 3610, 3621, 3644, 3664, 3768, 3797, 3812, 3834, 3840, 3866, 3895, 3904, 3914, 3946, 3954, 3984, 3999, 4005, 4012, 4023, 4037, 4062, 4067, 4078, 4107, 4122, 4180, 4187, 4190, 4193, 4250, 4255, 4282, 4294, 4312, 4321, 4336, 4349, 4362, 4370, 4384, 4388, 4451, 4455, 4469], 'c-Jun': [31, 114, 205, 283, 366, 457], 'N-terminal': [32, 115, 206, 284, 367, 458], 'kinase,': [33, 116, 285, 368], 'and': [34, 41, 117, 124, 134, 155, 171, 193, 215, 227, 238, 286, 293, 369, 376, 386, 407, 423, 445, 467, 479, 490, 537, 546, 644, 740, 832, 885, 895, 929, 1182, 1281, 1336, 1404, 1484, 1493, 1531, 1756, 1985, 2069, 2085, 2221, 2242, 2264, 2302, 2307, 2320, 2365, 2440, 2460, 2472, 2557, 2561, 2579, 2613, 2622, 2637, 2657, 2677, 2718, 2765, 2794, 2864, 2888, 2908, 2953, 2998, 3018, 3045, 3065, 3126, 3142, 3185, 3190, 3199, 3205, 3260, 3268, 3277, 3289, 3342, 3351, 3363, 3372, 3468, 3483, 3552, 3562, 3647, 3662, 3780, 3948, 4144, 4285, 4352, 4367, 4399, 4438, 4458], 'inactivation': [35, 118, 209, 287, 370, 461], 'extracellular': [37, 120, 211, 289, 372, 463, 509], 'regulated': [38, 121, 212, 290, 373, 464, 510, 4233], 'kinases': [39, 122, 291, 374], '1': [40, 123, 214, 292, 375, 466, 525, 2267, 2528, 2891, 2951, 3321, 4225, 4273], '2.': [42, 125, 216, 294, 377, 468], 'Here': [43, 295], 'we': [44, 83, 296, 335, 1106, 3233, 3772, 4074, 4357, 4378, 4440], 'report': [45, 297, 1105, 1980], 'results': [48, 300, 1488, 3243, 3809, 3956], 'the': [50, 62, 76, 86, 99, 104, 107, 110, 141, 160, 188, 201, 231, 302, 314, 328, 338, 351, 356, 359, 362, 393, 412, 440, 453, 483, 532, 629, 647, 655, 665, 729, 822, 856, 886, 898, 924, 943, 1110, 1279, 1736, 1878, 2071, 2099, 2106, 2130, 2248, 2368, 2402, 2424, 2428, 2623, 2642, 2649, 2658, 2705, 2714, 2724, 2734, 2760, 2795, 2831, 2871, 2926, 3009, 3015, 3019, 3034, 3046, 3063, 3066, 3090, 3096, 3104, 3138, 3180, 3214, 3217, 3226, 3247, 3356, 3381, 3407, 3446, 3461, 3488, 3517, 3534, 3560, 3589, 3611, 3619, 3645, 3774, 3788, 3795, 3826, 3896, 3926, 3943, 3952, 3969, 3982, 4006, 4035, 4041, 4050, 4058, 4063, 4068, 4083, 4089, 4105, 4111, 4127, 4140, 4166, 4178, 4185, 4209, 4217, 4248, 4253, 4258, 4265, 4279, 4292, 4298, 4329, 4334, 4347, 4360, 4443, 4456], 'caspase-dependent': [51, 303, 3909], 'cleavage': [52, 143, 304, 395, 1984, 3433, 3455, 3497, 3508, 3661, 3767, 3815, 3839, 3899, 3953, 4007, 4052, 4070, 4121], 'protein': [54, 306, 504, 513, 522, 926, 930, 2452, 2486, 2945, 3360, 3365, 3426, 3464, 3930, 4146, 4221, 4269], 'kinase': [55, 207, 213, 307, 459, 465, 505, 508, 511, 514, 520, 523, 524, 927, 931, 2453, 2481, 2544, 2568, 2833, 3964, 4131, 4155, 4158, 4261, 4299], 'C-δ': [56, 308], '(PKCδ)': [57, 309], 'a': [59, 68, 311, 320, 632, 861, 1624, 1743, 2060, 2222, 2332, 2342, 2356, 2663, 2683, 2692, 2751, 2920, 2928, 2932, 2947, 3051, 3078, 3432, 3491, 3495, 3813], '40-kDa': [60, 312, 3897], 'fragment,': [61, 313], 'appearance': [63, 105, 315, 357, 2706, 3181], 'which': [65, 317, 867, 2434, 2455, 2747, 3817, 3872], 'correlates': [66, 318, 3457, 3486, 4150], 'with': [67, 95, 153, 184, 319, 347, 405, 436, 640, 738, 1406, 1632, 1753, 2096, 2185, 2261, 2367, 2436, 2457, 2523, 2573, 2591, 2723, 2733, 2759, 2885, 2968, 3241, 3308, 3333, 3458, 3481, 3487, 3537, 3592, 3607, 3787, 3918, 4003, 4082, 4101, 4151], '9-fold': [69, 321, 4018], 'increase': [70, 175, 322, 427, 621, 3375, 3927, 3959, 4029, 4090, 4113, 4128, 4141, 4153, 4210, 4218, 4259], 'PKCδ': [72, 80, 128, 142, 164, 223, 324, 332, 380, 394, 416, 475, 1740, 1879, 2053, 2473, 2513, 3425, 3463, 3625, 3769, 3814, 3841, 4014, 4069, 4092, 4116, 4123, 4375, 4389, 4470], 'activity.': [73, 325, 4117], 'To': [74, 326, 2570, 2860, 3764, 3940, 4137, 4345, 4372, 4435], 'understand': [75, 327], 'function': [77, 329, 815], 'activated': [79, 241, 331, 493, 1698, 2055, 2089, 2103, 2574, 3203, 4315], 'apoptosis,': [82, 334, 3430, 4356], 'used': [85, 337, 2399, 3972, 4169, 4380, 4442], 'PKCδ-specific': [87, 339], 'inhibitor,': [88, 340], 'rottlerin.': [89, 341, 4381], 'Pretreatment': [90, 342, 3913], 'rottlerin': [96, 154, 348, 406, 4385], 'prior': [97, 349, 3617, 3793, 3863, 4103], 'addition': [100, 352, 2650, 3035, 3382, 3447, 3620, 3796, 4036, 4106, 4186, 4249, 4293], 'blocks': [103, 355, 3838, 4110], 'apoptotic': [108, 189, 232, 360, 441, 484, 823, 899, 2107, 3227, 3318, 3933, 4324], 'Inhibition': [126, 179, 378, 431], 'also': [129, 174, 381, 426, 936, 1981, 3427], 'partially': [130, 382], 'inhibits': [131, 383], 'fragmentation.': [136, 388], 'Immunoblot': [137, 389], 'analysis': [138, 390, 3547, 3631], 'shows': [139, 391, 1982, 3322], 'product': [144, 396, 3434, 3456, 3498, 3816, 3827, 4053, 4071], 'does': [145, 397, 4032], 'not': [146, 398, 3280, 3513, 3908, 3911, 3924, 3938, 4033, 4302], 'accumulate': [147, 399, 3441], 'treated': [152, 404, 737, 3332, 3532, 3587], 'together,': [157, 409], 'suggesting': [158, 410, 2114, 4048, 4227], 'catalytic': [161, 413, 1880, 4060], 'activity': [162, 414, 2072, 2475, 3983, 4015, 4031, 4093, 4132, 4179, 4200, 4213, 4230, 4244, 4262, 4281], 'may': [165, 245, 417, 497, 626, 1271, 2120, 3873, 4231, 4326], 'be': [166, 418, 940, 1272, 2111, 3820, 4232, 4327, 4393, 4463], 'required': [167, 419, 4125, 4340], 'for': [168, 420, 531, 893, 1627, 2078, 2256, 2317, 2328, 2494, 2498, 2527, 2627, 2880, 2905, 2916, 2955, 3026, 3131, 3337, 3344, 3533, 3588, 3604, 3790, 4126, 4160, 4341, 4386, 4453], 'cleavage.': [169, 421], 'PKCα': [170, 422, 1475, 1487, 1696, 2084, 2578, 3359, 3385, 3929, 3947, 4143, 4181, 4199, 4212, 4220, 4229, 4284, 4437, 4457], 'PKCβ1': [172, 424, 2086, 2580, 3267, 3364, 3395, 3949, 4145, 4243, 4286, 4353, 4439, 4459], 'activities': [173, 425], 'during': [176, 428, 2056, 3429, 3578, 4055, 4148, 4203, 4287, 4316], 'etoposide-induced': [177, 429, 2057, 4112, 4135, 4204, 4317], 'apoptosis.': [178, 430, 3579, 4136, 4205, 4318, 4371], 'these': [181, 433, 2082, 2102, 4161, 4337], 'two': [182, 434], 'isoforms': [183, 242, 435, 494, 1169, 1268, 2035, 2104, 2117, 2408, 3521, 4162, 4311], 'Gö6976': [185, 437, 4452], 'slightly': [186, 438, 3414, 3478], 'suppresses': [187, 439], 'but': [196, 448], 'has': [197, 449, 659, 1476, 2137], 'no': [198, 450, 4467], 'effect': [199, 451, 4361], 'on': [200, 452, 1109, 1278, 2167, 2315, 2355, 2662, 2903, 3050, 3968, 4165, 4291, 4365], 'or': [208, 460, 622, 743, 816, 870, 1275, 1636, 2488, 2512, 3330, 3506, 3596, 3615, 3623, 3799, 3846, 3870, 3920, 3951], 'These': [217, 469, 854, 2049, 3133], 'data': [218, 470], 'demonstrate': [219, 471, 2051, 4308], 'is': [224, 476, 529, 1697, 2054, 2076, 3270, 3279, 3397, 3770, 3850, 3854, 3907, 4016, 4072, 4124, 4289, 4332, 4339, 4390, 4460, 4471], 'an': [225, 477, 1323, 2361, 2479, 3230, 3317, 3323, 3633, 3860, 3958, 4152], 'integral': [226, 478], 'essential': [228, 480, 2077], 'part': [229, 481], 'program': [233, 485], 'specific': [240, 492, 1185, 1267, 2034, 2116, 3086, 3223, 3250, 3665, 4310], 'PKC': [244, 496, 1111, 1125, 1270, 1326, 1412, 1528, 1631, 2037, 2119, 2407, 3218, 3251, 3520, 3540, 3576, 3666, 3961, 4313, 4322, 4445], 'distinct': [247, 499, 2122], 'functions': [248, 500, 2123], 'death.': [251, 503, 2126], 'C': [506, 932], 'Jun-N-terminal': [507], 'mitogen-activated': [512, 521, 925, 2451], 'N-benzyloxycarbonyl-Val-Ala-Asp-(O-methyl)-CH2F': [515], 'N-benzyloxycarbonyl-Asp-Glu-Val-Asp-(O-methyl)-CH2F': [516], 'N-acetyl-Asp-Glu-ValAsp-p-nitroaniline': [517], '1-β-d-arabinofuranosylcytosine': [518, 3800], 'DNA-protein': [519], 'glutathione': [526], 'S-transferase': [527], 'Apoptosis': [528, 3075, 3176], 'important': [530], 'destruction': [533, 667], 'tumor': [535], 'damaged': [539], 'viral': [541], 'infection,': [542], 'drugs,': [543], 'chemical': [544], 'radiation,': [545], 'aging': [547], '(1Hickman': [548], 'J.A.': [549], 'Eur.': [550, 797, 1143, 1967], 'J.': [551, 570, 798, 973, 997, 1023, 1045, 1067, 1087, 1144, 1210, 1236, 1349, 1375, 1428, 1447, 1510, 1546, 1581, 1585, 1609, 1659, 1716, 1787, 1806, 1845, 1894, 1938, 1968, 2010, 2381, 2810, 3701, 3735, 3881, 4493], 'Cancer.': [552], '1996;': [553, 612, 693, 801, 1026, 1048, 1090, 1160, 1193, 1377, 1399, 1432, 1690, 1790, 1865, 1941, 3721], '32:': [554], '921-926Abstract': [555], 'Full': [556, 578, 596, 768, 979, 981, 1003, 1005, 1029, 1031, 1051, 1053, 1073, 1075, 1093, 1095, 1216, 1218, 1242, 1244, 1453, 1516, 1518, 1590, 1665, 1667, 1722, 1724, 1812, 1814, 1900, 1902, 2016, 2018, 2816, 2818, 3741, 3743], 'Text': [557, 579, 597, 769, 980, 982, 1004, 1006, 1030, 1032, 1052, 1054, 1074, 1076, 1094, 1096, 1217, 1219, 1243, 1245, 1454, 1517, 1519, 1591, 1666, 1668, 1723, 1725, 1813, 1815, 1901, 1903, 2017, 2019, 2817, 2819, 3742, 3744], 'PDF': [558, 580, 598, 770, 983, 1007, 1033, 1055, 1077, 1097, 1220, 1246, 1455, 1520, 1592, 1669, 1726, 1816, 1904, 2020, 2820, 3745], 'Scopus': [559, 582, 600, 616, 723, 772, 805, 850, 881, 914, 963, 985, 1009, 1035, 1057, 1079, 1099, 1150, 1164, 1197, 1222, 1248, 1294, 1316, 1355, 1381, 1435, 1522, 1566, 1594, 1617, 1671, 1728, 1794, 1818, 1850, 1906, 1945, 1974, 2022, 2160, 2822, 2856, 3172, 3706, 3747, 3760, 3886, 4431], '(189)': [560], 'Google': [561, 584, 602, 618, 696, 725, 774, 807, 852, 883, 916, 965, 987, 1011, 1037, 1059, 1081, 1101, 1152, 1166, 1199, 1224, 1250, 1296, 1305, 1318, 1357, 1383, 1402, 1437, 1457, 1472, 1524, 1568, 1596, 1619, 1673, 1693, 1730, 1796, 1820, 1852, 1869, 1908, 1947, 1976, 2024, 2162, 2387, 2824, 2858, 3174, 3708, 3725, 3749, 3762, 3888, 4433], 'Scholar,': [562, 585, 603, 697, 775, 966, 988, 1012, 1038, 1060, 1082, 1153, 1200, 1225, 1297, 1306, 1358, 1384, 1438, 1458, 1569, 1597, 1674, 1797, 1821, 1853, 1909, 1948, 3709, 3726, 3750], '2Dewey': [563], 'W.C.': [564], 'Ling': [565], 'C.C.': [566], 'Meyn': [567], 'R.E.': [568], 'Int.': [569], 'Radiat.': [571], 'Oncol.': [572, 1300], 'Biol.': [573, 959, 974, 998, 1024, 1046, 1068, 1088, 1159, 1192, 1211, 1237, 1448, 1511, 1612, 1660, 1717, 1807, 1895, 2011, 2156, 2811, 3168, 3736, 4494], 'Phys.': [574], '1995;': [575, 593, 1290, 1302, 1351, 1562, 1846, 3702], '33:': [576], '781-796Abstract': [577], 'PubMed': [581, 599, 615, 722, 771, 804, 849, 880, 913, 984, 1008, 1034, 1056, 1078, 1098, 1149, 1163, 1196, 1221, 1247, 1293, 1315, 1354, 1380, 1456, 1471, 1521, 1565, 1593, 1616, 1670, 1727, 1793, 1817, 1849, 1868, 1905, 1944, 1973, 2021, 2386, 2821, 2855, 3705, 3724, 3746, 3759, 3885, 4430], '(465)': [583], '3Enoch': [586], 'T.': [587, 681, 703, 748, 1344, 1760, 1805, 1835, 1911, 1954, 1956, 3691], 'Norbury': [588], 'C.': [589, 948, 968, 1142, 1676, 1768, 1919, 4492], 'Trends': [590], 'Biochem.': [591, 1145, 1969, 3880, 4423], 'Sci.': [592], '20:': [594], '426-430Abstract': [595], '(237)': [601], '4Harms-Ringdahl': [604], 'M.': [605, 675, 683, 687, 1202, 1285, 1372, 1390, 1444, 1601, 1607, 1762, 1833, 1913, 1962, 2840, 2850, 3113, 3115, 3121, 3287, 3689, 4410], 'Nicotera': [606], 'P.': [607, 950, 1442, 1772, 1923], 'Radford': [608], 'I.R.': [609], 'Mutat.': [610], 'Res.': [611, 1301, 1561, 4425], '366:': [613], '171-179Crossref': [614], '(87)': [617], 'Scholar).': [619, 726, 853, 917, 1102, 1167, 1319, 1473, 1525, 1620, 1694, 1731, 1870, 1977, 2025, 2163, 2388, 2825, 2859, 3175, 3763, 3889, 4434], 'An': [620, 2449], 'decrease': [623, 3485], 'contribute': [627], 'pathology': [630], 'wide': [633], 'range': [634], 'disorders': [636], 'including': [637, 921], 'those': [638], 'associated': [639], 'development,': [641], 'autoimmune': [642], 'disease,': [643], 'cancer.': [645], 'In': [646, 727, 1103, 1320, 1621, 2151, 2633, 3163, 3405, 3598, 4206, 4252], 'gland,': [649], 'inappropriate': [650], 'induction': [651, 1700], 'via': [654], 'FAS/FAS': [656], 'ligand': [657], 'pathway': [658], 'been': [660, 826, 937, 1477, 1535, 2138, 3675], 'suggested': [661], 'lead': [663], 'glandular': [666], 'seen': [668, 3354, 3803, 3977, 4096, 4133, 4147, 4174, 4238, 4472], "Sjögren's": [670], 'syndrome': [671], '(5Matsumura': [672], 'R.': [673, 1364, 1366, 1430, 1462, 1774, 1782, 1839, 1841, 1925, 1933, 2003, 3695, 3697, 3728, 4416], 'Kagami': [674], 'Tomioka': [676], 'H.': [677, 715, 786, 1340, 1360, 1682, 1780, 1829, 1857, 1931, 2005, 3685, 3713, 3730, 4482, 4488], 'Tanabe': [678], 'E.': [679, 707, 840, 1342, 1392, 1460, 1571, 1599, 3116], 'Sugiyama': [680], 'Sueishi': [682], 'Nakajima': [684], 'A.': [685, 1138, 1229, 1346, 1386, 1388, 2836, 2838, 3124, 3291, 3292], 'Azuma': [686], 'Okumura': [688], 'K.': [689, 758, 1227, 1394, 1464, 1950, 1952, 2007, 3123, 3732, 4414], 'Clin.': [690], 'Exp.': [691, 1559, 1788, 1939], 'Rheumatol.': [692], '14:': [694, 1847, 3703], '309-311PubMed': [695], '6Kong': [698], 'L.': [699, 838, 990, 994, 1420, 1579, 1603, 2803, 2807, 3120], 'Ogawa': [700], 'N.': [701, 713, 908, 1678], 'Nakabayashi': [702], 'Liu': [704], 'G.T.': [705], "D'Souza": [706], 'McGuff': [708], 'H.S.': [709], 'Guerrero': [710], 'D.': [711, 1018, 1140, 1209, 1299, 1362, 1426, 1554, 1680, 1786, 1843, 1863, 1937, 2009, 3127, 3699, 3719, 3734, 4490], 'Talal': [712], 'Dang': [714], 'Arthritis': [716], '&': [717, 844, 2154, 3166], 'Rheum.': [718], '1997;': [719, 846, 877, 960, 1000, 1070, 1213, 1239, 1613, 1662, 1719, 1897, 1970, 2013, 2813, 3738, 3882], '40:': [720], '87-97Crossref': [721], '(209)': [724], 'addition,': [728, 3193], 'normal': [732], 'patients': [736], 'head': [739], 'neck': [741], 'irradiation': [742], 'chemotherapeutics': [744], '(7Mansson-Rakemtulla': [745], 'B.': [746, 992, 2805, 2844], 'Techanitisivad': [747], 'Rakemutulla': [749], 'F.': [750, 4422], 'McMillan': [751], 'T.O.': [752], 'Bradley': [753], 'E.L.': [754], 'Wahlin': [755], 'Y.B.': [756], 'Kaen': [757], 'Oral': [759, 761, 763], 'Surg.': [760], 'Med': [762], 'Pathol.': [764], '1992;': [765, 1146], '73:': [766], '35-46Abstract': [767], '(38)': [773], '8Liem': [776], 'I.H.': [777], 'Olmos': [778], 'R.A.V.': [779], 'Balm': [780], 'A.J.M.': [781], 'Beus': [782], 'R.B.': [783], 'Van': [784], 'Tinteren': [785], 'Takes': [787], 'R.P.': [788], 'Muller': [789, 4411], 'S.H.': [790], 'Bruce': [791], 'A.M.': [792], 'Hoefnagel': [793], 'C.A.': [794, 2842], 'Hilger': [795], 'F.J.': [796], 'Nucl.': [799], 'Med.': [800, 876, 1789, 1940], '23:': [802], '1485-1490Crossref': [803], '(79)': [806], 'Scholar)': [808], 'can': [809, 1640], 'result': [810], 'reduced': [812], 'gland': [814, 2066, 3141], 'xerostomia.': [817], 'The': [818, 1124, 1526, 2026, 2127, 2309, 2430, 2516, 2667, 2727, 2753, 2775, 2897, 2961, 3029, 3055, 3207, 4304, 4382, 4449], 'critical': [819], 'genes': [820], 'process': [824, 2108], 'defined': [827, 3082], 'genetically': [828], 'Caenorhabditis': [830], 'elegans': [831], 'biochemically': [833], 'other': [835, 3671], 'species': [836], '(9Rao': [837], 'White': [839, 2378], 'Curr.': [841, 1156, 1189], 'Opin.': [842, 1157, 1190], 'Genet.': [843], 'Dev.': [845, 2155, 3167], '7:': [847, 1303, 1691], '52-58Crossref': [848], '(140)': [851], 'include': [855], 'Bcl-2': [857, 1481, 1491], 'family': [858, 862, 928, 1112, 1126, 3219], 'proteins,': [860, 866], 'related': [864], 'regulatory': [865], 'either': [868, 1273, 3835], 'promote': [869], 'suppress': [871], '(10Kroemer': [873], 'G.': [874, 902, 1424, 1827, 3683, 4420, 4478, 4486], 'Nat.': [875], '3:': [878], '614-620Crossref': [879], '(1717)': [882], 'Scholar),': [884, 1251, 1403], 'caspases,': [887], 'cysteine': [888], 'proteases': [889], 'are': [891, 1328, 2087, 4314, 4401], 'responsible': [892], 'initiation': [894], 'execution': [896], 'signal': [900], '(11Nunez': [901], 'Benedict': [903], 'M.A.': [904, 1207], 'Hu': [905], 'Y.': [906, 1368, 1466, 1715, 1770, 1776, 1801, 1823, 1825, 1855, 1859, 1893, 1921, 1927, 1958, 1960, 3679, 3681, 3711, 3715], 'Inohara': [907], 'Oncogene.': [909, 1311], '1998;': [910, 976, 1312, 1513, 1809, 2157, 2383, 3169, 3756], '17:': [911, 1614], '3237-3245Crossref': [912], '(949)': [915], 'Other': [918], 'signaling': [919, 3672], 'molecules,': [920, 3673], 'members': [922], '(PKC)1': [933], 'family,': [934], 'involved': [941], 'regulation': [944], '(12Widmann': [947], 'Gerwins': [949], 'Johnson': [951, 955, 971, 1549, 2847], 'N.L.': [952], 'Jarpe': [953], 'M.B.': [954], 'G.L.': [956, 972, 2848], 'Mol.': [957, 1397, 1610], 'Cell.': [958, 1586, 1611, 2153, 3165], '18:': [961], '2416-2429Crossref': [962], '(210)': [964], '13Widmann': [967], 'Gibson': [969], 'S.': [970, 1155, 1188, 1396, 1446, 1605, 1766, 1778, 1831, 1861, 1917, 1929, 1964, 1966, 3118, 3687, 3717], 'Chem.': [975, 999, 1025, 1047, 1069, 1089, 1212, 1238, 1449, 1512, 1661, 1718, 1808, 1896, 2012, 2812, 3737, 4495], '273:': [977, 1514, 1810], '7141-7147Abstract': [978], '(391)': [986], '14Butterfield': [989], 'Storey': [991, 2804], 'Maas': [993, 2806], 'Heasley': [995, 2785, 2808], 'L.E.': [996, 2809], '272:': [1001, 1071, 1214, 1240, 1663, 1720, 1898, 2014, 2814, 3739], '10110-10116Abstract': [1002, 2815], '(150)': [1010, 2823], '15Chen': [1013], 'Y.-R.': [1014, 1040], 'Wang': [1015, 1800], 'X.': [1016, 1505, 1648], 'Templeton': [1017], 'Davis': [1019, 2845], 'R.J.': [1020, 2846], 'Tan': [1021, 1043], 'T.-H.': [1022, 1044], '271:': [1027, 1049, 1091], '31929-31936Abstract': [1028], '(856)': [1036], '16Chen': [1039], 'Meyer': [1041], 'C.F.': [1042], '631-634Abstract': [1050], '(461)': [1058, 1080], '17Kummer': [1061], 'J.L.': [1062], 'Rao': [1063], 'P.K.': [1064], 'Heidenreich': [1065], 'K.A.': [1066, 2144, 3156], '20490-20494Abstract': [1072], '18Osborn': [1083], 'M.T.': [1084, 1573], 'Chambers': [1085], 'T.C.': [1086], '30950-30955Abstract': [1092], '(216)': [1100], 'this': [1104, 2074, 3283, 3454, 3484, 3905, 4028], 'focused': [1108], 'enzymes': [1114, 3221], 'potential': [1116], 'regulators': [1117], 'cells.': [1123, 2083], 'consists': [1127], '11': [1129], 'isoforms,': [1130, 1529, 3667], 'whose': [1131], 'expression': [1132, 1876, 2777, 3265, 3345, 3357, 3386, 3396, 3542, 3626, 4222], 'varies': [1133], 'between': [1134], 'types': [1136, 1544, 1875], '(19Azzi': [1137], 'Boscoboinik': [1139], 'Hensey': [1141], '208:': [1147], '547-557Crossref': [1148], '(320)': [1151], '20Jaken': [1154], 'Cell': [1158, 1191, 1560, 1687, 2349, 2693, 3753], '8:': [1161, 1194], '168-173Crossref': [1162, 1195], '(407)': [1165, 1198], 'Individual': [1168], 'exhibit': [1170], 'varying': [1171], 'substrate': [1172], 'specificity,': [1173], 'well': [1175, 3081, 3669], 'differences': [1177], 'their': [1179], 'subcellular': [1180], 'localization': [1181], 'stimuli': [1186, 4325], '(20Jaken': [1187], '21Csukai': [1201], 'Chen': [1203, 1369], 'C.-H.': [1204], 'De': [1205], 'Matteis': [1206], 'Mochly-Rosen': [1208], '29200-29206Abstract': [1215], '(220)': [1223], '22Nishikawa': [1226], 'Toker': [1228], 'Johannes': [1230], 'F.-J.': [1231], 'Songyan': [1232], 'Z.': [1233], 'Cantley': [1234], 'L.C.': [1235], '952-960Abstract': [1241], '(496)': [1249], 'arguing': [1252], 'they': [1254], 'specialized': [1256], 'roles': [1257], 'signaling.': [1260], 'A': [1261, 1978, 2525], 'variety': [1262], 'studies': [1264, 2028, 2050, 3209], 'indicate': [1265, 3557, 3642], 'pro-apoptotic': [1274, 1625], 'anti-apoptotic,': [1276], 'depending': [1277], 'stimulus': [1280], 'type': [1283], '(23Lucas': [1284], 'Sanchez-Margalet': [1286], 'V.': [1287], 'Gen.': [1288], 'Pharmacol.': [1289, 1398], '26:': [1291], '881-887Crossref': [1292], '(100)': [1295], '24Leszczynski': [1298], '471-480PubMed': [1304], '25Whelan': [1307], 'D.H.R.': [1308], 'Parker': [1309], 'P.J.': [1310], '16:': [1313], '1939-1944Crossref': [1314], '(137)': [1317], 'support': [1321, 1622], 'anti-apoptotic': [1324], 'function,': [1325], 'inhibitors': [1327, 3778, 3789, 4364], 'potent': [1329], 'inducers': [1330], 'many': [1334, 1417, 1542, 3144], 'hematopoietic': [1335], 'neoplastic': [1337], '(26Ikemoto': [1339], 'Tani': [1341], 'Matsumoto': [1343], 'Nakano': [1345], 'Furuyama': [1347], 'J.-I.': [1348], 'Neurosurg.': [1350, 1376], '83:': [1352], '1008-1016Crossref': [1353], '(77)': [1356], '27Hamilton': [1359], 'Hinton': [1361], 'Law': [1363], 'Gopalakrishna': [1365], 'Su': [1367], 'Z.-H.': [1370], 'Weiss': [1371], 'Couldwell': [1373], 'W.': [1374, 1548, 1684, 1686, 1784, 1837, 1935, 3693, 4418], '85:': [1378], '329-334Crossref': [1379], '(62)': [1382], '28Freemerman': [1385], 'Turner': [1387, 2149, 3161], 'Birrer': [1389], 'Szabo': [1391], 'Valerie': [1393], 'Grant': [1395], '49:': [1400], '788-795PubMed': [1401], 'phorbol': [1407, 1633], '12-myristate': [1408, 1634], '13-acetate': [1409], 'activate': [1411], 'antagonizes': [1413], 'induced': [1415, 1749, 3195], 'agents': [1418, 1705, 1998], '(29Romanova': [1419], 'Alexandrov': [1421], 'I.': [1422, 1575], 'Schwab': [1423], 'Hilbert': [1425], 'Mushinski': [1427], 'Nordan': [1429], 'Biochemistry.': [1431], '25:': [1433], '9900-9906Crossref': [1434], '(35)': [1436], '30McConkey': [1439], 'D.J.': [1440], 'Hartzell': [1441], 'Jondal': [1443], 'Orrenius': [1445], '1989;': [1450], '264:': [1451], '13399-13402Abstract': [1452], '31Solary': [1459], 'Bertrand': [1461], 'Kohn': [1463], 'Pommier': [1465, 1714, 1892], 'Blood.': [1467, 1864, 3720], '1993;': [1468, 1587, 4496], '81:': [1469], '1359-1368Crossref': [1470], 'Recently': [1474], 'phosphorylate': [1480, 3992], 'vitro,': [1483], 'overexpression': [1485, 1637], 'increased': [1490, 3387, 3398, 3944, 4017, 4267, 4280], 'phosphorylation': [1492, 2672, 3070, 4192], 'suppression': [1494], 'human': [1498], 'pre-B': [1499], 'REH': [1500], '(32Ruvolo': [1502], 'P.P.': [1503], 'Deng': [1504], 'Carr': [1506], 'B.K.': [1507], 'May': [1508], 'W.S.': [1509], '25436-25442Abstract': [1515], '(412)': [1523], 'atypical': [1527], 'PKCλ': [1530, 3278], 'PKCζ,': [1532, 3261], 'likewise': [1534, 2088, 3476, 3922], 'protect': [1538], 'against': [1539], '(33Pongracz': [1545], 'Tuffley': [1547], 'G.D.': [1550], 'Deacon': [1551], 'E.M.': [1552], 'Burnett': [1553], 'Stockley': [1555], 'R.A.': [1556], 'Lord': [1557], 'J.M.': [1558, 2148, 3160], '218:': [1563], '430-438Crossref': [1564], '(52)': [1567], '34Berra': [1570], 'Diaz-Meco': [1572, 1606], 'Dominguez': [1574], 'Muncio': [1576], 'M.M.': [1577], 'Sanz': [1578, 1602], 'Lozano': [1580], 'Chapkin': [1582], 'R.S.': [1583, 2146, 3158], 'Moscat': [1584, 1608], '74:': [1588], '555-563Abstract': [1589], '(343)': [1595], '35Berra': [1598], 'Municio': [1600], 'Frutos': [1604], '4346-4354Crossref': [1615], '(161)': [1618], 'role': [1626, 4348], 'PKC,': [1628], '13-acetate,': [1635], 'PKCα,': [1639, 2470, 3258, 3347, 3504, 4351, 4397], 'induce': [1641, 2000, 3101], 'prostatic': [1644], 'carcinoma': [1645], '(36Zhao': [1647], 'Gschwend': [1649], 'J.E.': [1650], 'Powell': [1651], 'C.T.': [1652], 'Foster': [1653], 'R.G.': [1654], 'Day': [1655, 1657], 'K.C.': [1656], 'M.L.': [1658], '22751-22757Abstract': [1664], '(58)': [1672], '37Powell': [1675], 'Brittis': [1677], 'Stec': [1679], 'Hug': [1681, 4487], 'Heston': [1683], 'Fair': [1685], 'Growth': [1688], 'Differ.': [1689, 3295, 3755], '419-428PubMed': [1692], 'Likewise,': [1695], 'following': [1699, 2090, 3445, 3479, 3522, 4134, 4184, 4247], 'genotoxic': [1704, 2047], 'HL-60': [1707], 'myeloid': [1708], '(38Shao': [1710, 1888], 'R.-G.': [1711, 1889], 'Cao': [1712, 1890], 'C.-X.': [1713, 1891], '31321-31325Abstract': [1721, 1899], '(67)': [1729, 1907], 'Several': [1732], 'laboratories': [1733], 'reported': [1735, 3677, 4391, 4461], 'proteolytic': [1737], 'release': [1742], 'catalytically': [1744], 'active': [1745], 'fragment': [1746, 3906], 'ionizing': [1754], 'radiation': [1755], 'DNA-damaging': [1757], 'drugs': [1758], '(39Ghayur': [1759], 'Hugunin': [1761, 1912], 'Talanian': [1763, 1914], 'R.V.': [1764, 1915], 'Ratnofsky': [1765, 1916], 'Quinlan': [1767, 1918], 'Emoto': [1769, 1920], 'Pandey': [1771, 1922], 'Datta': [1773, 1924], 'Huang': [1775, 1926], 'Kharbanda': [1777, 1830, 1860, 1928, 3686, 3716], 'Allen': [1779, 1930], 'Kamen': [1781, 1838, 1932, 3694], 'Wong': [1783, 1836, 1934, 3692], 'Kufe': [1785, 1842, 1862, 1936, 2008, 3698, 3718, 3733], '184:': [1791, 1942], '2399-2404Crossref': [1792, 1943], '(447)': [1795, 1946], '40Denning': [1798], 'M.F.': [1799], 'Nickoloff': [1802], 'B.J.': [1803], 'Smith-Wrone': [1804], '29995-30002Abstract': [1811], '(204)': [1819], '41Emoto': [1822], 'Manome': [1824, 1858, 3680, 3714], 'Meinhardt': [1826, 3682], 'Kisaki': [1828, 1856, 3684, 3712], 'Robertson': [1832, 3688], 'Ghayur': [1834, 3690], 'Weichselbaum': [1840, 3696], 'EMBO': [1844, 3700], '6148-6156Crossref': [1848, 3704], '(652)': [1851, 3707], '42Emoto': [1854, 3710], '87:': [1866, 3722], '1990-1996Crossref': [1867, 3723], 'Furthermore,': [1871], 'several': [1873], 'domain': [1881, 4061], 'induces': [1882], 'phenotypic': [1883], 'changes': [1884, 3088, 3245], 'indicative': [1885], '39Ghayur': [1910], '43Mizuno': [1949], 'Noda': [1951], 'Araki': [1953], 'Imaoka': [1955], 'Kobayashi': [1957], 'Akita': [1959], 'Shimonaka': [1961], 'Kishi': [1963], 'Ohno': [1965], '250:': [1971], '7-18Crossref': [1972], '(118)': [1975], 'recent': [1979], 'PKCθ': [1988], 'occurs': [1991, 3076], 'U937': [1993], '(44Datta': [2002], 'Kojima': [2004, 3729], 'Yoshida': [2006, 3731], '20317-20320Abstract': [2015, 3740], '(266)': [2023, 3748], 'present': [2027], 'were': [2029, 2165, 2232, 2245, 2353, 2409, 2519, 2587, 2625, 2646, 2755, 2768, 2798, 2868, 2963, 3031, 3135, 3210, 3510, 3531, 3586, 3602, 3785, 3966, 4163], 'undertaken': [2030, 3211], 'ask': [2032], 'if': [2033, 3235, 3766, 3942, 4076, 4139], 'regulate': [2038], 'agents.': [2048], 'line': [2062, 2136], 'derived': [2063, 3136], 'from': [2064, 2234, 2347, 2411, 2444, 2464, 2641, 2698, 2742, 2770, 3137], 'isoform': [2075, 3541, 4446], 'complete': [2079], 'etoposide;': [2097], 'however,': [2098, 4257], 'contribution': [2100, 3215], 'appears': [2109, 3818, 4214], 'more': [2112, 3851], 'modest,': [2113], 'isolation': [2128], 'immortalized': [2131], 'described': [2139, 2372, 2493, 2594, 2801, 3549, 3637, 4306], 'elsewhere': [2140], '(45Quissell': [2141, 3153], 'D.O.': [2142, 3154], 'Barzen': [2143, 3155], 'Redman': [2145, 3157], 'Camden': [2147, 3159], 'J.T.': [2150, 3162], 'Vitro': [2152, 3164], '34:': [2158, 3170], '58-67Crossref': [2159, 3171], '(55)': [2161, 3173], 'Cells': [2164], 'cultured': [2166], 'Primaria': [2168], '60-mm': [2169], 'culture': [2170, 2230, 2249, 2872], 'dishes': [2171], '(Falcon': [2172], 'Plastics,': [2173], 'Franklin': [2174], 'Lakes,': [2175], 'NJ)': [2176], "Dulbecco's": [2178], 'modified': [2179], "Eagle's": [2180], 'medium/F-12': [2181], '(1:1': [2182], 'mixture)': [2183], 'supplemented': [2184], '2.5%': [2186], 'fetal': [2187], 'calf': [2188], 'serum,': [2189], '5': [2190, 2202, 2215, 2329, 2614, 2917, 3391], 'μg/ml': [2191, 2203, 2218, 2304, 2608], 'transferrin,': [2192], '1.1': [2193], 'μm': [2194, 2555, 2611, 3000, 3335, 3594, 3609, 4475], 'hydrocortisone,': [2195], '0.1': [2196, 2281, 2978, 2992], 'μmretinoic': [2197], 'acid,': [2198], '2.0': [2199], 'nm': [2200], 'triiodothyronine,': [2201], 'insulin,': [2204], '80': [2205], 'ng/ml': [2206], 'epidermal': [2207], 'growth': [2208], 'factor': [2209], '(Collaborative': [2210], 'Biomedical': [2211], 'Products,': [2212], 'Bedford,': [2213], 'MA),': [2214], 'mml-glutamine,': [2216], '50': [2217, 2607, 2973, 2987, 3309, 3334, 3538, 3593], 'gentamicin': [2219], 'sulfate,': [2220], 'trace': [2223], 'element': [2224], 'mixture': [2225], '(Biofluids,': [2226], 'Rockville,': [2227], 'MD).': [2228], 'Tissue': [2229], 'reagents': [2231], 'obtained': [2233, 2410, 2443, 2463, 2741, 2769], 'Life': [2235], 'Technologies,': [2236], 'Inc.': [2237], 'unless': [2238], 'otherwise': [2239], 'indicated.': [2240], 'Adherent': [2241], 'floating': [2243, 2865], 'scraped': [2246, 2869], 'into': [2247, 2870], 'media,': [2250, 2873], 'collected': [2251, 2520, 2874], 'centrifugation': [2253, 2876], '(3,000': [2254, 2877], '×g': [2255], '10': [2257, 2299, 2628, 2881, 2996, 3003, 3037], 'min),': [2258, 2882], 'washed': [2259, 2533, 2883, 2965, 3016], 'once': [2260, 2884], 'phosphate-buffered': [2262, 2886], 'saline,': [2263, 2887], 'resuspended': [2265, 2562, 2889], 'ml': [2268, 2892, 2952], 'JNK': [2270, 2537, 2826, 2894, 3198], 'lysis': [2271, 2538, 2895], 'buffer': [2272, 2545, 2600], '(25': [2273], 'mm': [2274, 2279, 2291, 2294, 2297, 2300, 2547, 2552, 2559, 2974, 2979, 2988, 2993], 'HEPES,': [2275], 'pH': [2276, 2549, 2971, 2990], '7.5,': [2277], '20': [2278, 2551, 2554, 2564, 2969, 2999, 3027], 'β-glycerophosphate,': [2280, 2989], 'mmsodium': [2282], 'orthovanadate,': [2283, 2995], '0.1%': [2284], 'Triton': [2285, 2982], 'X-100,': [2286], '0.3': [2287], 'm': [2288], 'NaCl,': [2289, 2975], '1.5': [2290], 'MgCl2,': [2292, 2553], '0.2': [2293], 'EDTA,': [2295, 2980], '0.5': [2296, 2489], 'dithiothreitol,': [2298], 'NaF,': [2301], '4': [2303, 2499, 2502, 2531, 2959, 3370, 3402, 3443, 3997, 4241], 'each': [2305], 'aprotinin': [2306], 'leupeptin).': [2308], 'lysate': [2310, 2898], 'was': [2311, 2339, 2398, 2442, 2462, 2476, 2496, 2581, 2620, 2639, 2673, 2689, 2719, 2731, 2779, 2828, 2899, 2937, 3012, 3021, 3059, 3071, 3177, 3543, 3627], 'allowed': [2312, 2900], 'sit': [2314, 2902], 'ice': [2316, 2904], '30': [2318, 2631, 2906, 3024, 3605, 3791], 'min': [2319, 2330, 2629, 2907, 2918, 3606, 3792], 'then': [2321, 2909, 2964], 'clarified': [2322, 2910], 'spinning': [2324, 2912], 'at': [2325, 2501, 2530, 2630, 2913, 2958, 3023, 3859, 4403, 4474], '12,500': [2326, 2914], 'rpm': [2327, 2915], 'refrigerated': [2333, 2921], 'Savant': [2334, 2922], 'SRF13K': [2335, 2923], 'microcentrifuge.': [2336, 2924], 'Protein': [2337], 'concentration': [2338], 'determined': [2340, 2674, 3060, 3072, 3544, 3987, 4020], 'using': [2341, 2478, 2504, 2583, 2682, 2691, 2830, 3632], 'Bradford': [2343], 'assay': [2344, 2482, 2703, 2834, 2927], 'kit': [2345, 2697], 'purchased': [2346], 'Bio-Rad.': [2348], 'lysates': [2350, 2585, 3971, 4168], '(25–50': [2351], 'μg)': [2352], 'resolved': [2354, 2661, 3049], '10%': [2357, 2933, 3052], 'gel,': [2358, 3064], 'transferred': [2359], 'Immobilon': [2362], 'membrane': [2363], '(Millipore),': [2364], 'immunoblotted': [2366], 'desired': [2369], 'antibody': [2370, 3635], '(46Reyland': [2374], 'M.E.': [2375], 'Williams': [2376], 'D.L.': [2377], 'E.K.': [2379], 'Am.': [2380], 'Physiol.': [2382], '275:': [2384], 'C780-C789Crossref': [2385], 'Enhanced': [2389], 'chemiluminescence': [2390], '(ECL,': [2391], 'Amersham': [2392], 'Pharmacia': [2393], 'Biotech)': [2394], 'followed': [2395], 'autoradiography': [2397, 2676], 'detect': [2401], 'signal.': [2403], 'Antibodies': [2404], 'all': [2406], 'Santa': [2412], 'Cruz': [2413], 'Biotechnology': [2414, 2446, 2466], '(Santa': [2415], 'Cruz,': [2416], 'CA).': [2417, 2774], 'All': [2418], 'anti-PKC': [2419], 'antibodies': [2420], 'recognize': [2421], 'epitopes': [2422], 'C-terminal': [2425, 4051], 'portion': [2426], 'protein.': [2429], 'anti-active': [2431], 'ERK2': [2432], 'antibody,': [2433, 2454], 'cross-reacts': [2435, 2456], 'both': [2437, 2458, 2862, 4283], 'phosphorylated': [2438], 'ERK1': [2439, 2459, 3204], 'ERK2,': [2441, 2461], 'Promega': [2445], '(Madison,': [2447], 'WI).': [2448], 'anti-': [2450], 'Upstate': [2465], '(Lake': [2467], 'Placid,': [2468], 'NY).': [2469], 'PKCβ1,': [2471, 3348, 3505, 4256], 'enzymatic': [2474], 'assayed': [2477, 2690, 2829, 3628], 'immunoprecipitation': [2480, 2576, 2590, 3963, 4157], 'follows.': [2484], 'Cytosolic': [2485], '(0.25': [2487], 'mg),': [2490], 'prepared': [2491, 2799], 'immunoblotting,': [2495], 'immunoprecipitated': [2497], 'h': [2500, 2529, 2957, 3305, 3371, 3379, 3444, 3998, 4011], '°C': [2503, 3025], '2': [2505, 2956], 'μg': [2506, 2941], 'anti-PKCα': [2508], '(C-20),': [2509], 'anti-PKCβ1': [2510], '(C-16),': [2511], '(C-17)': [2514], 'antibody.': [2515], 'antigen-antibody': [2517], 'complexes': [2518], 'incubation': [2522], 'Sepharose-protein': [2524], '(Sigma)': [2526], '°C,': [2532], '3': [2534, 2540, 3980, 4024, 4045, 4194], 'times': [2535, 2541, 2967, 3536], 'buffer,': [2539, 2655, 3043], '2×': [2543, 2567, 2652], '(40': [2546, 4407], 'Tris,': [2548], '7.4,': [2550], 'ATP,': [2556], '2.5': [2558, 2976], 'CaCl2),': [2560], 'μl': [2565, 2597, 2985, 3038], 'buffer.': [2569, 2644, 2896], 'prevent': [2571], 'contamination': [2572], 'PKCδ,': [2575, 3259, 3349, 3955, 3985, 4278, 4350], 'done': [2582], 'pre-cleared': [2588], 'anti-PKCδ': [2592], 'above.': [2595, 3638], 'Twenty': [2596], 'reaction': [2599, 2643, 2659, 3020, 3047, 4300], '(0.4': [2601], 'mg': [2602], 'H1': [2604, 2670], 'histone': [2605, 2671, 3993, 4191], '(Sigma),': [2606], 'phosphatidylserine,': [2609], '4.1': [2610], 'dioleoylglycerol,': [2612], 'μCi': [2615], '[γ-32P]ATP': [2617, 3005], '(3000': [2618], 'Ci/mm))': [2619], 'added,': [2621], 'samples': [2624], 'incubated': [2626, 2954, 3022], '°C.': [2632, 2960], 'some': [2634, 2679, 3599, 4207], 'experiments': [2635, 2680, 4196, 4208, 4305], 'phosphatidylserine': [2636], 'dioleoylglycerol': [2638], 'omitted': [2640], 'Reactions': [2645], 'terminated': [2647, 3032], 'SDS': [2653, 3041], 'sample': [2654, 3042], 'boiled,': [2656, 3044], 'products': [2660, 3048, 3509], '12.5%': [2664], 'SDS-polyacrylamide': [2665, 3053], 'gel.': [2666, 3054], 'extent': [2668, 3067], 'quantified': [2681], 'PhosphorImager': [2684], '(Molecular': [2685], 'Dynamics).': [2686], 'fragmentation': [2688], 'Death': [2694, 3294, 3754], 'Detection': [2695], 'Assay': [2696, 2738], 'Roche': [2699], 'Molecular': [2700], 'Biochemicals.': [2701], 'This': [2702, 4118], 'detects': [2704], 'histone-associated': [2708], 'low': [2709], 'molecular': [2710, 3564, 3649, 3823], 'weight': [2711, 3824], 'cytoplasm': [2715], 'performed': [2720, 3967, 4164], 'accordance': [2722, 2758], "manufacturer's": [2725, 2761], 'recommendations.': [2726, 2762], 'detected': [2732, 3511], 'Caspase-3': [2735], 'Cellular': [2736], 'Activity': [2737], 'Kit': [2739], 'PLUS': [2740], 'Biomol': [2743], '(Plymouth': [2744], 'Meeting,': [2745], 'PA)': [2746], 'usesN-acetyl-Asp-Glu-Val-Asp-p-nitroaniline': [2748], '(Ac-DEVD.FMK-pNA)': [2749], 'substrate.': [2752], 'assays': [2754, 3965, 4159], 'conducted': [2756], 'Z-VAD.FMK': [2763, 3614, 3779, 3849, 3853, 3919, 4086, 4102], '(Z-Val-Ala-Asp-(O-methyl)-CH2F)': [2764], 'DEVD.FMK': [2766, 3921], '(Z-Asp-Glu-Val-Asp-(O-methyl)-CH2F)': [2767], 'Enzyme': [2771], 'Systems': [2772], '(Livermore,': [2773], 'GST-c-Jun-(1–79)': [2776, 2936], 'vector': [2778], 'kindly': [2780], 'provided': [2781], 'Dr.': [2783], 'Lynn': [2784], '(University': [2786], 'Colorado': [2788], 'Health': [2789], 'Sciences': [2790], 'Center,': [2791], 'Denver,': [2792], 'CO),': [2793], 'fusion': [2796], 'proteins': [2797], '(14Butterfield': [2802], 'GST-Jun': [2832, 3058, 3069], '(47Minden': [2835], 'Lin': [2837], 'McMahon': [2839], 'Lange-Carter': [2841], 'Derijard': [2843], 'Karin': [2849], 'Science.': [2851], '1994;': [2852, 4427], '266:': [2853], '1719-1723Crossref': [2854], '(1012)': [2857], 'collect': [2861], 'adherent': [2863], 'cells,': [2866], '×': [2878], 'g': [2879], 'For': [2925], '100-μl': [2929], 'volume': [2930, 2949], 'suspension': [2934], 'added': [2938, 3013], '300': [2940], 'total': [2943], 'cellular': [2944], 'final': [2948, 3010], 'beads': [2962], 'three': [2966], 'mmHEPES,': [2970], '7.7,': [2972], 'mmMgCl2,': [2977, 2997], '0.05%': [2981], 'X-100.': [2983], 'Forty': [2984], '7.6,': [2991], 'sodium': [2994], 'ATP': [3001], 'containing': [3002], 'mCi': [3004], '(5000': [3006], 'cpm/pmol': [3007], 'reaction)': [3011], 'beads,': [3017], 'min.': [3028], 'reactions': [3030], '5×': [3040], 'position': [3056], 'staining': [3062], 'autoradiography.': [3074], 'series': [3079], 'steps': [3083], 'involve': [3085], 'biochemical': [3087, 4366], 'cell.': [3091], 'examined': [3095, 4359], 'ability': [3097, 3990], 'line.': [3111, 3285], '2S.': [3112], 'Anderson,': [3114], 'Reyland,': [3117], 'Hunter,': [3119], 'Deisher,': [3122], 'Barzen,': [3125], 'O.': [3128], 'Gwissel,': [3129], 'submitted': [3130], 'publication.': [3132], 'rat': [3139], 'retain': [3143], 'characteristics': [3145], 'displayed': [3146], 'vivo': [3152], 'demonstrated': [3178], 'cytoplasmic': [3183], 'blebbing': [3184], 'nuclear': [3186], 'condensation,': [3187], 'activation.2In': [3192], 'suppressed': [3200], 'accumulation': [3201, 3489, 3811, 3894, 3931, 4066], 'ERK2.2': [3206], 'current': [3208], 'explore': [3213], 'events': [3224], 'process.': [3228], 'As': [3229, 3298, 3353, 3802, 3976, 4095, 4173, 4237], 'initial': [3231], 'approach': [3232], 'asked': [3234, 4075], 'abundance': [3248, 3408, 3945, 4270], 'isoforms.': [3252], 'Parotid': [3253, 3782], 'strongly': [3256], 'express': [3257], 'whereas': [3262, 3394, 3431, 4396, 4466], 'much': [3263], 'weaker': [3264], 'PKCε': [3269, 3410, 3507], 'detected.': [3271], 'Expression': [3272, 3422, 3471], 'PKCβ11,': [3274], 'PKCγ,': [3275], 'PKCη,': [3276], 'detectable': [3281], '3Reyland,': [3286], 'E.,': [3288], 'Matassa,': [3290], '(1999)Cell': [3293], '6,': [3296], '454–462.': [3297], 'Fig.5': [3301], 'B,': [3302, 4099, 4242], '18': [3304, 3340, 3378, 4010], 'μmetoposide,': [3310], '>80%': [3311], 'display': [3316], 'morphology.': [3319], 'Fig.': [3320, 3469, 3805, 3974, 3979, 4171, 4224, 4240, 4272, 4275], 'immunoblot': [3324, 3546, 3630], 'untreated': [3326], 'up': [3338, 3376], 'h,': [3341], 'probed': [3343], 'PKCε,': [3350], 'PKCζ.': [3352], 'here,': [3355], '(panel': [3361, 3366, 3411, 3450, 3474], 'A),': [3362, 4226], 'B)': [3367], 'increases': [3368, 3995, 4182, 4201, 4245], 'continues': [3373], 'after': [3380], 'etoposide.': [3384, 3597, 3624, 3832, 4188, 4251], 'about': [3388, 3399, 3419, 3500], '2–3-fold': [3389], 'similar': [3392, 3403, 4025, 4195], 'experiments,': [3393], '3–5-fold': [3400], 'experiments.': [3404, 4026], 'contrast,': [3406], 'C)': [3412], 'decreases': [3413, 3428, 3477], 'etoposide-treated': [3416], '12': [3420], 'h.': [3421], 'full-length': [3424, 3462], 'approximately': [3436], '40': [3437, 3501, 3608], 'kDa': [3438], 'begins': [3439], 'D).': [3451], 'Accumulation': [3452], 'loss': [3459], '(Fig.': [3465, 4044], '1,panel': [3466], 'D,': [3467], '2).': [3470], 'PKCζ': [3473, 3496, 3898], 'E)': [3475], 'etoposide,': [3482, 3847], 'small': [3492], 'amount': [3493], 'kDa.': [3502], 'No': [3503], '(data': [3512, 3910, 3937, 4301], 'shown).Figure': [3514], '1Changes': [3515], 'levels': [3518], 'treatment.': [3524], 'Subconfluent': [3525, 3580], 'cultures': [3526, 3581], 'μmetoposide.': [3539], 'under': [3550], '"Materials': [3551], 'Methods."': [3553], 'Solid': [3554], 'andopen': [3555], 'arrows': [3556, 3641], 'migration': [3558, 3643], '68-': [3561, 3646], '43-kDa': [3563, 3648], 'mass': [3565, 3650], 'markers,': [3566, 3651], 'respectively.View': [3567], 'Large': [3568, 3655], 'Image': [3569, 3656], 'Figure': [3570, 3657], 'ViewerDownload': [3571, 3658], '(PPT)Figure': [3572], '2Caspase-dependent': [3573], 'δ': [3577], 'time': [3591], 'ara-C': [3595, 3622, 3807, 3845], 'instances': [3600], 'pretreated': [3603, 3786], 'caspase': [3612, 3777, 3836, 3891, 4084], 'inhibitors,': [3613], 'DEVD.FMK,': [3616], 'anti-PKCδ-specific': [3634], 'Solidand': [3639], 'open': [3640], 'respectively.': [3652], 'UT,': [3653], 'untreated.View': [3654], '(PPT)': [3659], 'Caspase-dependent': [3660], '(41Emoto': [3678], '44Datta': [3727], '48Bokoch': [3751], 'G.M.': [3752, 3879], '5:': [3757], '637-645Crossref': [3758], '(49)': [3761], 'determine': [3765, 3941, 4138], 'caspase-dependent,': [3771, 4073], 'utilized': [3773], 'cell-permeable,': [3775], 'irreversible,': [3776], 'DEVD.FMK.': [3781], '(ara-C).': [3801], '2,': [3806], 'identical': [3821], 'generated': [3828, 4054], 'Inclusion': [3833], 'inhibitor': [3837, 3892, 4085, 4447], 'although': [3848], 'potent.': [3852], 'thought': [3855], 'inhibit': [3857, 4373, 4436], 'early': [3861], 'stage,': [3862], 'caspases-2,': [3867], '-3,': [3868], '-6,': [3869], '-7,': [3871], 'explain': [3874], 'its': [3875, 3989], 'higher': [3876, 4405], 'potency': [3877], '(49Cohen': [3878], '326:': [3883], '1-16Crossref': [3884], '(4146)': [3887], 'Neither': [3890], 'blocked': [3893], 'product,': [3900], 'indicating': [3901], 'generation': [3903, 4004], 'shown).': [3912, 3939, 4303], 'did': [3923], 'block': [3925, 4088], 'protein,': [3950], 'activity,': [3962, 4156], '1.': [3975, 4172], 'A,': [3981, 4046, 4177], 'H1,': [3994], 'treatment,': [4001], 'coincident': [4002], 'fragment.': [4008], 'By': [4009], 'quantification': [4022], 'Notably,': [4027], 'require': [4034], 'lipid': [4038, 4296], 'activators': [4039], 'vitroreaction': [4043], '−Lipid),': [4047], 'represents': [4057], 'free': [4059], 'molecule.': [4064], 'Since': [4065], 'pretreatment': [4077, 4100], 'could': [4087], 'observed.': [4094], 'Fig.3': [4098], 'completely': [4109], 'lipid-independent': [4115, 4130], 'indicates': [4119, 4197], 'Fig.4': [4176], 'dramatically': [4183], 'Quantification': [4189], '3–8-fold': [4202], 'exceed': [4216], '(see': [4223], 'additional': [4235], 'mechanisms.': [4236], '5–6-fold': [4246], 'case': [4254], 'closely': [4263], 'parallels': [4264], 'observed': [4266], '(compare': [4271], '4).': [4276], 'Unlike': [4277], 'dependent': [4290], 'exogenous': [4295], 'above': [4307], 'Although': [4319], 'important,': [4328], 'fundamental': [4330], 'question': [4331], 'whether': [4333], 'molecules': [4338], 'occur.': [4344], 'address': [4346], 'isoform-specific': [4363], 'morphologic': [4368], 'markers': [4369], 'specifically': [4374], 'vivo,': [4377], 'IC50': [4383, 4450], 'inhibition': [4387, 4454, 4468], '3–6': [4394], 'μm,': [4395], 'PKCβ,': [4398], 'PKCγ': [4400], 'inhibited': [4402], 'significantly': [4404], 'concentrations': [4406, 4476], 'μm)': [4408], '(50Gschwendt': [4409], 'H.-J.': [4412], 'Kielbassa': [4413], 'Zang': [4415], 'Kittstein': [4417], 'Rincke': [4419], 'Marks': [4421], 'Biophys.': [4424], 'Commun.': [4426], '199:': [4428], '93-98Crossref': [4429], '(762)': [4432], 'calcium-dependent': [4444], 'Gö6976.': [4448], '2–6': [4464], 'nm,': [4465], 'even': [4473], '(51Martiny-Baron': [4477], 'Kazanietz': [4479], 'M.G.': [4480], 'Mischak': [4481], 'Blumberg': [4483], 'P.M.': [4484], 'Kochs': [4485], 'Marme': [4489], 'Schachtele': [4491], '268:': [4497], '9194-9197Abstract': [4498], 'Ful': [4499]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2013634259', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-14T03:49:57.124223', 'created_date': '2016-06-24'}
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