Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2013602946', 'doi': 'https://doi.org/10.1111/j.1464-410x.2005.05821.x', 'title': 'Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer', 'display_name': 'Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer', 'publication_year': 2005, 'publication_date': '2005-09-29', 'ids': {'openalex': 'https://openalex.org/W2013602946', 'doi': 'https://doi.org/10.1111/j.1464-410x.2005.05821.x', 'mag': '2013602946', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16287438'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1464-410x.2005.05821.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S191188855', 'display_name': 'BJU International', 'issn_l': '1464-4096', 'issn': ['1464-4096', '1464-410X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': 'https://doi.org/10.1111/j.1464-410x.2005.05821.x', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5000156180', 'display_name': 'Gerhardt Attard', 'orcid': 'https://orcid.org/0000-0002-4811-7983'}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Gerhardt Attard', 'raw_affiliation_strings': ['Institute for Cancer Research/The Royal Marsden NHS Foundation Trust, Centre for Cancer Therapeutics, Sutton, Surrey, UK, and'], 'affiliations': [{'raw_affiliation_string': 'Institute for Cancer Research/The Royal Marsden NHS Foundation Trust, Centre for Cancer Therapeutics, Sutton, Surrey, UK, and', 'institution_ids': ['https://openalex.org/I1325846038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108509552', 'display_name': 'Arie S. Belldegrun', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Arie S. Belldegrun', 'raw_affiliation_strings': ['UCLA David Geffen School of Medicine, Department of Urology, Los Angeles, California, USA'], 'affiliations': [{'raw_affiliation_string': 'UCLA David Geffen School of Medicine, Department of Urology, Los Angeles, California, USA', 'institution_ids': ['https://openalex.org/I161318765']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5072378199', 'display_name': 'Johann S. de Bono', 'orcid': 'https://orcid.org/0000-0002-2034-595X'}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Johann S. De Bono', 'raw_affiliation_strings': ['Institute for Cancer Research/The Royal Marsden NHS Foundation Trust, Centre for Cancer Therapeutics, Sutton, Surrey, UK, and'], 'affiliations': [{'raw_affiliation_string': 'Institute for Cancer Research/The Royal Marsden NHS Foundation Trust, Centre for Cancer Therapeutics, Sutton, Surrey, UK, and', 'institution_ids': ['https://openalex.org/I1325846038']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.096, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 210, 'citation_normalized_percentile': {'value': 0.812183, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '96', 'issue': '9', 'first_page': '1241', 'last_page': '1246'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11395', 'display_name': 'Radiopharmaceutical Chemistry and Applications', 'score': 0.9869, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9764, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/foundation', 'display_name': 'Foundation (evidence)', 'score': 0.42049363}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7284584}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.6667801}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.51703006}, {'id': 'https://openalex.org/C161191863', 'wikidata': 'https://www.wikidata.org/wiki/Q199655', 'display_name': 'Library science', 'level': 1, 'score': 0.4206291}, {'id': 'https://openalex.org/C2780966255', 'wikidata': 'https://www.wikidata.org/wiki/Q5474306', 'display_name': 'Foundation (evidence)', 'level': 2, 'score': 0.42049363}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.23184344}, {'id': 'https://openalex.org/C17744445', 'wikidata': 'https://www.wikidata.org/wiki/Q36442', 'display_name': 'Political science', 'level': 0, 'score': 0.11205682}, {'id': 'https://openalex.org/C199539241', 'wikidata': 'https://www.wikidata.org/wiki/Q7748', 'display_name': 'Law', 'level': 1, 'score': 0.09584424}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D059002', 'descriptor_name': 'Androgen Receptor Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000737', 'descriptor_name': 'Androstenols', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D008190', 'descriptor_name': 'Lyases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000736', 'descriptor_name': 'Androstenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000737', 'descriptor_name': 'Androstenols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004341', 'descriptor_name': 'Drug Evaluation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008190', 'descriptor_name': 'Lyases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009362', 'descriptor_name': 'Neoplasm Metastasis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D009362', 'descriptor_name': 'Neoplasm Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D013254', 'descriptor_name': 'Steroid 17-alpha-Hydroxylase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013254', 'descriptor_name': 'Steroid 17-alpha-Hydroxylase', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1464-410x.2005.05821.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S191188855', 'display_name': 'BJU International', 'issn_l': '1464-4096', 'issn': ['1464-4096', '1464-410X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16287438', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1464-410x.2005.05821.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S191188855', 'display_name': 'BJU International', 'issn_l': '1464-4096', 'issn': ['1464-4096', '1464-410X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1947561494', 'https://openalex.org/W1970568381', 'https://openalex.org/W1993808852', 'https://openalex.org/W2000824159', 'https://openalex.org/W2003955264', 'https://openalex.org/W2014476883', 'https://openalex.org/W2024432096', 'https://openalex.org/W2027081726', 'https://openalex.org/W2038911580', 'https://openalex.org/W2053306253', 'https://openalex.org/W2058818042', 'https://openalex.org/W2060524703', 'https://openalex.org/W2064360128', 'https://openalex.org/W2071383020', 'https://openalex.org/W2078704234', 'https://openalex.org/W2080498417', 'https://openalex.org/W2085581871', 'https://openalex.org/W2088987876', 'https://openalex.org/W2108955823', 'https://openalex.org/W2109694492', 'https://openalex.org/W2110171529', 'https://openalex.org/W2117296712', 'https://openalex.org/W2120292596', 'https://openalex.org/W2129876849', 'https://openalex.org/W2135435665', 'https://openalex.org/W2139903767', 'https://openalex.org/W2140855177', 'https://openalex.org/W2147995093', 'https://openalex.org/W2171041379', 'https://openalex.org/W4242439059', 'https://openalex.org/W4242531351', 'https://openalex.org/W4242771572', 'https://openalex.org/W4295773257'], 'related_works': ['https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2899084033', 'https://openalex.org/W2748952813', 'https://openalex.org/W2604872355', 'https://openalex.org/W2080531066', 'https://openalex.org/W2048182022', 'https://openalex.org/W1995515455', 'https://openalex.org/W1506200166'], 'abstract_inverted_index': {'BJU': [0], 'InternationalVolume': [1], '96,': [2], 'Issue': [3], '9': [4], 'p.': [5], '1241-1246': [6, 311], 'Selective': [7], 'blockade': [8], 'of': [9, 84, 87, 187, 190, 261, 271, 284, 295], 'androgenic': [10], 'steroid': [11], 'synthesis': [12], 'by': [13, 72, 96, 126, 175, 199, 229], 'novel': [14], 'lyase': [15], 'inhibitors': [16], 'as': [17], 'a': [18, 292], 'therapeutic': [19], 'strategy': [20], 'for': [21, 33, 42, 51, 60, 69, 93, 107, 116, 123, 136, 145, 154, 163, 172, 196, 210, 219, 226], 'treating': [22], 'metastatic': [23], 'prostate': [24], 'cancer': [25], 'Gerhardt': [26, 30, 129, 133], 'Attard,': [27, 49, 130, 152], 'Corresponding': [28, 131], 'Author': [29, 132], 'Attard': [31, 134], 'Institute': [32, 50, 106, 135, 153, 209], 'Cancer': [34, 43, 52, 61, 108, 117, 137, 146, 155, 164, 211, 220], 'Research/The': [35, 53, 109, 138, 156, 212], 'Royal': [36, 54, 110, 139, 157, 213], 'Marsden': [37, 55, 111, 140, 158, 214], 'NHS': [38, 56, 112, 141, 159, 215], 'Foundation': [39, 57, 113, 142, 160, 216], 'Trust,': [40, 58, 114, 143, 161, 217], 'Centre': [41, 59, 115, 144, 162, 218], 'Therapeutics,': [44, 62, 118, 147, 165, 221], 'Sutton,': [45, 63, 119, 148, 166, 222], 'Surrey,': [46, 64, 120, 149, 167, 223], 'UK,': [47, 121, 150, 224], 'andGerhardt': [48, 151], 'UK.': [65, 168], 'e-mail:': [66, 169], '[email': [67, 170], 'protected]Search': [68, 171], 'more': [70, 94, 124, 173, 197, 227], 'papers': [71, 95, 125, 174, 198, 228], 'this': [73, 97, 127, 176, 200, 230, 296], 'authorArie': [74, 177], 'S.': [75, 78, 99, 103, 178, 181, 202, 206], 'Belldegrun,': [76, 179], 'Arie': [77, 180], 'Belldegrun': [79, 182], 'UCLA': [80, 183], 'David': [81, 184], 'Geffen': [82, 185], 'School': [83, 186], 'Medicine,': [85, 188], 'Department': [86, 189], 'Urology,': [88, 191], 'Los': [89, 192], 'Angeles,': [90, 193], 'California,': [91, 194], 'USASearch': [92, 195], 'authorJohann': [98, 201], 'De': [100, 104, 203, 207], 'Bono,': [101, 204], 'Johann': [102, 205], 'Bono': [105, 208], 'andSearch': [122, 225], 'author': [128, 231], 'First': [232], 'published:': [233], '15': [234], 'November': [235], '2005': [236], 'https://doi.org/10.1111/j.1464-410X.2005.05821.xCitations:': [237], '155Read': [238], 'the': [239, 277, 287], 'full': [240, 251], 'textAboutPDF': [241], 'ToolsRequest': [242], 'permissionExport': [243], 'citationAdd': [244], 'to': [245, 267, 290], 'favoritesTrack': [246], 'citation': [247], 'ShareShare': [248], 'Give': [249], 'accessShare': [250, 253], 'text': [252], 'full-text': [254, 269, 293], 'accessPlease': [255], 'review': [256], 'our': [257], 'Terms': [258, 281], 'and': [259, 263, 275, 282, 301], 'Conditions': [260, 283], 'Use': [262], 'check': [264], 'box': [265], 'below': [266, 289], 'share': [268, 291], 'version': [270, 294], 'article.I': [272], 'have': [273], 'read': [274], 'accept': [276], 'Wiley': [278], 'Online': [279], 'Library': [280], 'UseShareable': [285], 'LinkUse': [286], 'link': [288], 'article': [297], 'with': [298], 'your': [299], 'friends': [300], 'colleagues.': [302], 'Learn': [303], 'more.Copy': [304], 'URL': [305], 'Citing': [306], 'Literature': [307], 'Volume96,': [308], 'Issue9December': [309], '2005Pages': [310], 'RelatedInformation': [312]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2013602946', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 18}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 19}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 13}, {'year': 2014, 'cited_by_count': 13}, {'year': 2013, 'cited_by_count': 23}, {'year': 2012, 'cited_by_count': 23}], 'updated_date': '2024-12-09T08:36:53.888038', 'created_date': '2016-06-24'}