Crucial Role for Nuclear Factor of Activated T Cells in T Cell Receptor-mediated Regulation of Human Interleukin-17

Name: Work Video:
Duration: 3 min 30 s
Xikui K. Liu; Xin Lin; Sarah L. Gaffen
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287, 293, 311, 344, 426, 510, 517, 946, 1077, 1081, 1265, 1356, 1388, 1395, 1541, 1649, 1665, 1787, 1827, 1833, 1840, 1878, 1898, 1907, 1948, 1972, 2059, 2068, 2082, 2090, 2128, 2167, 2187, 2197, 2237, 2292, 2310, 2331, 2339, 2347, 2381, 2399, 2403, 2449, 2491, 2599, 2743, 2807, 2820, 2919, 2953, 2976, 2988, 2990, 3083, 3156, 3180, 3190, 3206, 3293, 3306, 3319, 3328, 3376, 3402, 3451, 3478, 3485, 3490, 3515, 3554, 3574, 3601, 3609, 3692, 3720, 3748, 3757, 3772, 3793, 3809, 3814, 3836, 3938, 3966, 3985, 3988, 4004, 4025, 4038, 4161, 4175, 4191, 4208, 4221, 4229, 4239, 4262, 4279, 4283, 4290, 4297, 4308, 4315, 4319, 4329, 4333, 4360, 4398], 'inflammatory': [5, 265, 683, 749], 'cytokine': [6, 266, 741, 1359, 1396, 3348], 'interleukin': [7, 267, 523], '(IL)-17': [8, 268, 524], 'have': [9, 124, 269, 384, 1398, 1613, 1681, 2180], 'been': [10, 270, 605, 667, 1399, 1682], 'widely': [11, 271], 'studied.': [12, 272], 'However,': [13, 273, 1517, 1648, 1952, 3055, 4043, 4389], 'comparatively': [14, 274], 'little': [15, 275], 'is': [16, 22, 249, 276, 282, 509, 742, 1059, 1088, 1099, 1308, 1539, 1620, 1746, 1790, 1956, 1971, 3136, 3173, 3414, 3473, 3605, 3723, 3798, 3813, 3980, 4100, 4116, 4124, 4195, 4200], 'known': [17, 277, 1089, 3560], 'about': [18, 278, 1090, 3406], 'how': [19, 279], 'IL-17': [20, 35, 37, 64, 72, 128, 142, 167, 258, 280, 295, 297, 324, 332, 388, 402, 427, 518, 645, 665, 1062, 1093, 1097, 1196, 1261, 1307, 1366, 1407, 1453, 1531, 1545, 1619, 1657, 2136, 2159, 2176, 2199, 2288, 2311, 2376, 2977, 2980, 2994, 3001, 3053, 3064, 3096, 3121, 3135, 3149, 3157, 3188, 3358, 3523, 3537, 3549, 3575, 3643, 3659, 3726, 3801, 3833, 4095, 4298, 4310, 4320], 'expression': [21, 281, 1596, 1617, 1674, 3167], 'controlled.': [23, 283], 'Here,': [24, 284], 'we': [25, 75, 123, 170, 285, 335, 383, 430, 1573, 2131, 2144, 2179, 2999, 3210, 3297, 3551, 3687, 4322], 'examined': [26, 286, 2132, 3000, 3374, 3688], 'basis': [28, 288], 'for': [29, 71, 159, 162, 188, 289, 331, 419, 422, 448, 1584, 1958, 1985, 2175, 2193, 2255, 2287, 2514, 2523, 2639, 2759, 2770, 2809, 2863, 2895, 2936, 3024, 3339, 3607, 3984, 3998, 4037, 4118, 4127, 4203, 4341], 'transcriptional': [30, 85, 290, 345, 2306, 2332, 3191, 3207, 3308, 3834], 'regulation': [31, 291, 1091, 2195, 3101, 3186, 3521, 3661], 'human': [34, 294, 532, 2162, 2198, 2340, 3005, 3134, 3320, 3378, 3526], 'gene.': [36, 296, 1829, 2200], 'secretion': [38, 298, 3002, 3122], 'was': [39, 91, 105, 115, 186, 299, 351, 365, 375, 446, 581, 2208, 2313, 2350, 2414, 2442, 2452, 2619, 2652, 2804, 2827, 2859, 2944, 2965, 3102, 3194, 3212, 3287, 3360, 3373, 3404, 3410, 3458, 3505, 3646, 3710, 3839, 3971, 4028, 4047, 4059, 4164, 4183, 4276, 4376, 4383], 'induced': [40, 300, 3125, 3137, 3455], 'in': [41, 93, 118, 147, 151, 207, 241, 256, 301, 353, 378, 407, 411, 467, 501, 516, 608, 651, 686, 747, 751, 761, 945, 1067, 1070, 1102, 1368, 1385, 1434, 1450, 1518, 1848, 1912, 1981, 2079, 2086, 2094, 2138, 2147, 2158, 2161, 2233, 2236, 2266, 2338, 2357, 2464, 2468, 2898, 2918, 2952, 3003, 3007, 3094, 3108, 3112, 3162, 3177, 3347, 3375, 3395, 3524, 3536, 3548, 3616, 3658, 3725, 3754, 3820, 3832, 3845, 3937, 3957, 3995, 4012, 4030, 4084, 4167, 4170, 4343, 4379], 'peripheral': [42, 302, 2217], 'blood': [43, 303, 2207, 2218], 'mononuclear': [44, 304, 2219], 'cells': [45, 96, 137, 305, 356, 397, 1107, 1193, 1256, 1319, 1404, 1445, 1457, 1522, 1579, 1655, 1672, 1817, 2220, 2230, 2263, 2463, 2511, 2754, 3384, 3572, 3743, 3843, 3959, 4070, 4086, 4169, 4235, 4345], 'following': [46, 97, 306, 357, 1748, 2382, 2742, 3138, 3960], 'anti-CD3': [47, 307, 2240, 3030, 3059, 3127, 3390, 3457], 'cross-linking': [48, 308, 1263, 3023, 3462, 3503, 4179], 'to': [49, 126, 203, 309, 386, 463, 678, 953, 1355, 1401, 1405, 1446, 1529, 1544, 1663, 1770, 1796, 1837, 1860, 1875, 1945, 2056, 2149, 2324, 2425, 2688, 2713, 2806, 2818, 2973, 3009, 3017, 3325, 3417, 3448, 3475, 3519, 3542, 3561, 3737, 3826, 4061, 4064, 4172, 4180], 'activate': [50, 310, 1824, 4250], 'T': [52, 95, 120, 136, 312, 355, 380, 396, 535, 543, 1106, 1192, 1255, 1266, 1403, 1456, 1534, 1654, 1671, 1816, 2163, 3011, 3164, 3170, 3379, 3527], 'cell': [53, 313, 536, 1267, 1789, 2842, 3012, 3380, 3811], 'receptor': [54, 314, 648, 1268, 3022], '(TCR),': [55, 315], 'and': [56, 99, 102, 110, 145, 177, 183, 205, 212, 226, 230, 316, 359, 362, 370, 405, 437, 443, 465, 472, 486, 490, 590, 600, 622, 646, 700, 756, 913, 1253, 1312, 1378, 1394, 1604, 1622, 1820, 1845, 1856, 1861, 1885, 1903, 2046, 2053, 2061, 2076, 2113, 2170, 2178, 2205, 2216, 2261, 2281, 2303, 2346, 2369, 2392, 2405, 2421, 2448, 2487, 2517, 2519, 2541, 2586, 2602, 2613, 2630, 2633, 2700, 2717, 2762, 2792, 2825, 2861, 2893, 2910, 2942, 2949, 3019, 3060, 3071, 3087, 3141, 3202, 3286, 3354, 3370, 3413, 3504, 3530, 3567, 3587, 3698, 3700, 3716, 3774, 3795, 3942, 3990, 4000, 4009, 4087, 4114, 4223, 4268, 4292, 4354], 'costimulatory': [57, 317, 3143], 'signaling': [58, 154, 255, 318, 414, 515, 1666, 1761, 1800, 1865, 1953, 1970, 1979, 2043, 3056, 3080, 3144, 3545, 3823, 3829, 3940, 4046, 4089], 'through': [59, 319, 1440, 1954, 2044, 2051, 2987, 4090], 'CD28': [60, 100, 320, 360, 1361, 1780, 1955, 1969, 2047, 2152, 3146, 4178, 4211], 'strongly': [61, 321], 'enhanced': [62, 141, 322, 401, 3063, 3460, 3508, 4287], 'CD3-induced': [63, 323], 'production.': [65, 325, 3054, 3097, 3150], 'To': [66, 164, 326, 424, 3184, 4215], 'define': [67, 327, 3828, 4314], 'cis-acting': [68, 328], 'elements': [69, 329, 3476], 'important': [70, 330, 4202], 'gene': [73, 228, 333, 488, 521, 2092, 2312, 3349, 3367, 3397, 3453, 3497, 3660, 3708], 'regulation,': [74, 334, 3350, 3550, 3835], 'cloned': [76, 336, 2397, 3298], '1.25': [77, 337], 'kb': [78, 338, 3300], 'genomic': [80, 340, 2341, 3321], 'sequence': [81, 341, 652, 2618, 3303, 3316, 3335], 'upstream': [82, 342, 2329, 3304, 3362, 3799, 3944, 4093], 'start': [86, 346, 2307, 2333, 3192, 3208, 3309], 'site.': [87, 347], 'This': [88, 348, 740, 3098, 3356, 3471, 4073], 'putative': [89, 349, 3337, 3357], 'promoter': [90, 114, 143, 190, 350, 374, 403, 450, 2189, 2377, 3359, 3492, 3576, 3644, 3802, 4027, 4096, 4163, 4181, 4205, 4284, 4334, 4372], 'active': [92, 117, 352, 377, 4166], 'Jurkat': [94, 148, 213, 354, 408, 473, 2260, 3377, 3383, 3571, 3810, 3842, 4069, 4234, 4344], 'CD3': [98, 358, 2045, 3018, 3500, 4173, 4194], 'cross-linking,': [101, 361, 4174], 'its': [103, 363, 647, 676, 1595, 3371], 'activity': [104, 364, 2525, 3372, 3398, 3423, 3454, 3498, 3513, 3645, 3709, 3956, 4023, 4058, 4182, 4381], 'inhibited': [106, 366], 'by': [107, 367, 1310, 1455, 1533, 1652, 1668, 1779, 2224, 2289, 2315, 2352, 2416, 2444, 2796, 2829, 2946, 2967, 2983, 3041, 3081, 3090, 3126, 3179, 3197, 3456, 3461, 3468, 3509, 3599, 3713, 4049], 'cyclosporin': [108, 368, 546], 'A': [109, 369, 1963, 3596, 3804], 'MAPK': [111, 371, 2049, 2171, 3531, 3689, 3721, 3796, 4222, 4251], 'inhibitors.': [112, 372], 'also': [116, 376, 822, 948, 1194, 3092, 3711, 4285], 'Hut102': [119, 211, 379, 471, 2262, 2753], 'cells,': [121, 381, 1314, 1535, 2151, 3111, 3450, 4014, 4032], 'which': [122, 201, 382, 461, 1449, 1653, 1669, 1802, 1822, 1858, 1896, 1943, 1976, 3077, 3113, 3604, 3993, 4199], 'shown': [125, 385, 1400, 3201], 'secrete': [127, 387, 1195, 1447], 'constitutively.': [129, 389], 'Overexpression': [130, 390], 'nuclear': [132, 208, 392, 468, 539, 1804, 1812, 1904, 2584], 'factor': [133, 393, 540, 1813, 1909, 1950], 'activated': [135, 395, 542, 586, 1103, 1670, 1747, 1815], '(NFAT)': [138, 398], 'or': [139, 399, 1784, 2248, 2257, 2484, 2837, 3026, 3067, 3501, 3584, 3900, 4253, 4352], 'Ras': [140, 400, 2052, 2485, 4248, 4255, 4291], 'activity,': [144, 229, 404, 489, 4206], 'studies': [146, 406, 1079, 1612], 'lines': [149, 409], 'deficient': [150, 410, 944], 'specific': [152, 223, 412, 483, 3474], 'TCR': [153, 254, 413, 514, 3079, 3139, 3822, 3961], 'pathways': [155, 415, 2050, 2172, 3546, 3690, 3797, 3830, 4225, 4294], 'provided': [156, 416, 2443], 'supporting': [157, 417], 'evidence': [158, 418, 4219], 'a': [160, 172, 179, 420, 432, 439, 670, 680, 1064, 1071, 1525, 1751, 1797, 1982, 2139, 2155, 2504, 2731, 3340, 3364, 3418, 3481, 3637, 3981, 4035, 4101, 4244, 4257, 4324], 'role': [161, 421, 1066, 4036], 'NFAT.': [163, 423, 3355, 3785, 4010], 'delineate': [165, 425], 'minimal': [168, 428], 'promoter,': [169, 429, 2084, 3479, 4231, 4263, 4321], 'created': [171, 431, 2379, 2415, 4323], 'series': [173, 433, 4325], '5′': [175, 435, 4330], 'truncations': [176, 436, 4327], 'identified': [178, 438, 2181, 3211, 3307, 4103], 'region': [180, 240, 440, 500], 'between': [181, 441], '-232': [182, 442, 4365, 4396], '-159': [184, 444, 2972], 'that': [185, 247, 445, 507, 594, 1061, 1306, 1437, 1537, 1576, 1615, 2065, 2190, 2992, 3106, 3124, 3133, 3142, 3655, 3719, 3789, 4065, 4077, 4088, 4106, 4190, 4220, 4382], 'sufficient': [187, 447], 'inducible': [189, 449, 4056], 'activity.': [191, 451, 3803, 4097, 4288], 'Interestingly,': [192, 452, 643, 3205], 'two': [193, 453, 2182, 2418], 'NFAT': [194, 237, 248, 454, 497, 508, 1910, 2183, 2601, 2617, 3610, 3765, 4039, 4131, 4224, 4293, 4302], 'sites': [195, 219, 455, 479, 2185, 2407, 3338, 4317], 'were': [196, 456, 1582, 2222, 2231, 2264, 2285, 2322, 2364, 2378, 2396, 2433, 2466, 2496, 2512, 2521, 2546, 2606, 2641, 2704, 2720, 2728, 2755, 2778, 2785, 2794, 2816, 2839, 2872, 2902, 2912, 2929, 3734, 3744, 4236, 4339], 'located': [197, 457, 3288], 'within': [198, 458, 2186, 3477, 4307, 4318], 'this': [199, 239, 459, 499, 3334, 3408], 'region,': [200, 460], 'bound': [202, 462], 'NFATc1': [204, 464, 2483, 4275], 'NFATc2': [206, 466], 'extracts': [209, 469], 'from': [210, 470, 584, 653, 955, 1893, 2210, 2434, 2454, 2642, 2706, 2722, 3057, 3105, 3145, 3215, 3318, 3327, 3489, 4193, 4328], 'cells.': [214, 474, 1371, 2164, 3528], 'Moreover,': [215, 475, 2165], 'mutations': [216, 476], 'these': [218, 244, 478, 504, 1793, 3731, 4085], 'dramatically': [220, 480], 'reduced': [221, 481, 988], 'both': [222, 482, 644, 2166, 3058, 3565, 3714, 4007, 4264], 'DNA': [224, 484, 2070, 2342, 2943, 2964, 3762, 3779], 'binding': [225, 485, 2071, 2184, 3330, 3763, 3780], 'reporter': [227, 487, 2478, 3366, 3396, 3452, 3496], 'chromatin': [231, 491, 562, 2732, 2821], 'immunoprecipitation': [232, 492, 2733], 'assays': [233, 493, 2727], 'showed': [234, 494, 4256, 4286], 'occupancy': [235, 495], 'at': [238, 498, 596, 744, 1197, 2402, 2498, 2773, 2845, 2866, 2914, 2939, 3069, 3175, 3973, 4265], 'vivo.': [242, 502], 'Together,': [243, 503, 1792, 2073], 'data': [245, 505, 1433, 2337, 2343, 3322, 3787, 3976, 4188], 'show': [246, 506, 949, 1436, 3495], 'crucial': [251, 511, 4117], 'sensor': [252, 512], 'promoter.': [259, 519, 2978, 4299], 'encoding': [522], '1The': [525], 'abbreviations': [526], 'used': [527, 2356, 2638], 'are:': [528], 'IL,': [529], 'interleukin;': [530], 'hIL,': [531], 'IL;': [533], 'TCR,': [534, 4005], 'receptor;': [537], 'NFAT,': [538, 2074, 4198], 'cells;': [544], 'CsA,': [545, 3642], 'A;': [547], 'Ab,': [548], 'antibody;': [549], 'PKC,': [550], 'protein': [551, 1937, 1974, 4108], 'kinase': [552, 1938, 3933, 4109], 'C;': [553], 'IP3,': [554], 'inositol': [555, 1882], '1,4,5-trisphosphate;': [556], 'DAG,': [557], 'diacylglycerol;': [558], 'PLC,': [559], 'phospholipase;': [560], 'CHIP,': [561], 'immunoprecipitation;': [563], 'EMSA,': [564, 2537], 'electrophoretic': [565], 'mobility': [566], 'shift': [567], 'assay;': [568], 'PMA,': [569], 'phorbol': [570, 1390], '12-myristate': [571, 1391], '13-acetate;': [572], 'JNK,': [573, 2054], 'c-Jun': [574], 'N-terminal': [575], 'kinase;': [576], 'ERK,': [577], 'extracellular': [578], 'signal-regulated': [579], 'kinase.': [580], 'first': [582, 3195, 3552], 'isolated': [583, 2223], 'an': [585, 591, 950, 1757, 2527, 2634, 3393, 3539], 'rodent': [587], 'T-cell': [588], 'hybridoma,': [589], 'emerging': [592], 'family': [593, 3611], 'contains': [595], 'least': [597, 3176], 'six': [598], 'cytokines': [599, 1677, 3172], 'five': [601], 'receptors': [602], 'has': [603, 666], 'now': [604], 'recognized': [606], '(reviewed': [607, 685, 760, 1911, 2093, 3615], 'Refs.': [609, 687, 762, 2095], '1Aggarwal': [610, 688], 'S.': [611, 689, 704, 865, 966, 999, 1031, 1033, 1039, 1047, 1117, 1127, 1142, 1161, 1178, 1289, 1379, 1477, 1491, 1554, 1605, 2027, 2115, 2570, 3228, 3238, 3253], 'Gurney': [612, 690, 1499, 1555], 'A.L.': [613, 691, 1500], 'J.': [614, 692, 772, 842, 903, 927, 978, 1140, 1143, 1213, 1243, 1292, 1328, 1343, 1375, 1422, 1480, 1501, 1560, 1601, 1638, 1688, 1707, 1917, 2003, 2097, 2671, 3251, 3254, 3279, 3433, 3623, 3676, 3918, 4147], 'Leukocyte': [615, 693], 'Biol.': [616, 694, 1502, 2032, 2672, 3891], '2002;': [617, 695, 791, 800, 1017, 1693, 1922, 2008, 3923, 4152], '71:': [618, 696], '1-8PubMed': [619, 697], 'Google': [620, 641, 698, 738, 782, 806, 819, 850, 876, 895, 911, 941, 1028, 1055, 1152, 1171, 1188, 1227, 1248, 1300, 1333, 1351, 1430, 1488, 1515, 1568, 1646, 1704, 1721, 1933, 2014, 2039, 2111, 2125, 2578, 2685, 3263, 3284, 3445, 3634, 3684, 3859, 3875, 3898, 3929, 4158], 'Scholar': [621, 699, 2112], '2Moseley': [623], 'T.A.': [624], 'Haudenschild': [625], 'D.R.': [626], 'Rose': [627], 'L.': [628, 833, 1115, 1376, 1380, 1602, 1606, 1997, 2666, 3226, 3621, 3912, 4141], 'Reddi': [629], 'A.H.': [630], 'Cytokine': [631, 1732], 'Growth': [632], 'Factor': [633], 'Rev.': [634], '2003;': [635, 889, 1049, 1294, 1482, 1504, 3628], '14:': [636, 777], '155-174Crossref': [637], 'PubMed': [638, 779, 803, 816, 847, 873, 892, 908, 938, 1025, 1052, 1149, 1168, 1185, 1224, 1297, 1348, 1427, 1485, 1512, 1565, 1643, 1701, 1718, 1930, 2011, 2036, 2108, 2122, 2575, 2682, 3260, 3442, 3631, 3681, 3856, 3872, 3895, 3926, 4155], 'Scopus': [639, 780, 804, 817, 848, 874, 893, 909, 939, 1026, 1053, 1150, 1169, 1186, 1225, 1298, 1349, 1428, 1486, 1513, 1566, 1644, 1702, 1719, 1931, 2012, 2037, 2109, 2123, 2576, 2683, 3261, 3443, 3632, 3682, 3857, 3873, 3896, 3927, 4156], '(750)': [640], 'Scholar).': [642, 739, 942, 983, 1056, 1249, 1301, 1352, 1431, 1516, 1569, 1647, 1742, 1934, 2040, 2126, 2686, 3446, 3635, 4159], 'are': [649, 660, 1658, 2173, 2191, 3994, 4020], 'distinct': [650], 'previously': [654, 2550, 2656, 3217], 'described': [655, 1358, 2549, 2655], 'cytokine/receptor': [656], 'families,': [657], 'although': [658, 1190, 1591, 4374], 'they': [659, 1592], 'quite': [661], 'conserved': [662], 'among': [663], 'mammals.': [664], 'classified': [668], 'as': [669, 992, 994, 1679, 1854, 2365, 2548, 2607, 2654, 3039, 3951], 'key': [671, 1808, 1864, 1966], 'proinflammatory': [672], 'mediator': [673, 1967], 'based': [674, 2335, 3314], 'on': [675, 1756, 1786, 2081, 2336, 2503, 2526, 2812, 3315, 4213, 4228, 4261], 'ability': [677, 952], 'induce': [679, 3052], 'variety': [681, 1072], 'effectors': [684], '3Huang': [701], 'S.H.': [702], 'Frydas': [703], 'Kempuraj': [705], 'D.': [706, 855, 1129, 1236, 1989, 2017, 3240, 3272, 3904, 4133], 'Barbacane': [707], 'R.C.': [708], 'Grilli': [709], 'A.': [710, 796, 1003, 1048, 1411, 1556, 1627, 1690, 1711, 1730, 1919, 2101, 2571, 3431, 3625, 3665, 3851, 3864], 'Boucher': [711], 'W.': [712, 1421, 1637, 2556, 3675], 'Letourneau': [713], 'R.': [714, 837, 922, 1035, 1208, 2019], 'Madhappan': [715], 'B.': [716, 859, 1134, 2560, 3245], 'Papadopoulou': [717], 'N.': [718, 720, 861, 900, 1157, 1176, 1493, 1548, 1550], 'Verna': [719], 'De': [721], 'Lutiis': [722], 'M.A.': [723, 1726, 2562, 2670, 3849], 'Iezzi': [724], 'T.': [725, 829, 881, 1321, 1342, 2023], 'Riccioni': [726], 'G.': [727, 831, 968, 1413, 1629, 2001, 3667, 3916, 4145], 'Theoharides': [728], 'T.C.': [729], 'Conti': [730], 'P.': [731, 785, 857, 960, 964, 972, 1113, 1123, 1138, 1325, 3224, 3234, 3249, 3437], 'Allergy': [732], 'Asthma': [733], 'Proc.': [734, 1042, 2565], '2004;': [735, 813, 905, 1562, 2033, 2119], '25:': [736, 981], '17-21PubMed': [737], 'found': [743, 1101, 1575, 2145], 'elevated': [745], 'levels': [746, 1200, 1259, 3036, 4062, 4267], 'many': [748], 'conditions': [750], 'humans,': [752, 1096], 'particularly': [753, 1941], 'rheumatoid': [754], 'arthritis': [755], 'lung': [757], 'airway': [758, 989], 'infections': [759, 958], '4van': [763], 'Bezooijen': [764], 'R.L.': [765], 'Farih-Sips': [766], 'H.C.M.': [767], 'Papapoulos': [768], 'S.E.': [769], 'Löwik': [770], 'C.W.G.M.': [771], 'Bone': [773], 'Miner.': [774], 'Res.': [775, 811], '1999;': [776, 870, 1182, 1330], '1513-1521Crossref': [778], '(139)': [781], 'Scholar,': [783, 794, 807, 896, 1029, 1153, 1172, 1228, 1334, 1489, 1705, 1722, 2015, 3264, 3860], '5Schwarzenberger': [784], 'Kolls': [786, 975, 1290, 1478], 'J.K.': [787, 976, 1291, 1479], 'Mod.': [788], 'Aspects': [789], 'Immunobiol.': [790], '2:': [792], '176-177Google': [793], '6Linden': [795], 'Adachi': [797], 'M.': [798, 835, 839, 1007, 1013, 1163, 1180, 1273, 1323, 1409, 1461, 1625, 2662, 3663], 'Allergy.': [799], '57:': [801], '769-775Crossref': [802], '(78)': [805, 894], '7Gaffen': [808], 'S.L.': [809, 1232, 1724, 2552, 2658, 3268], 'Arthritis': [810], 'Ther.': [812], '6:': [814], '240-247Crossref': [815], '(103)': [818], 'Scholar),': [820, 851, 877, 912, 1189], 'but': [821, 3466, 3766, 3783], 'Heliobacter': [823], 'pylori': [824], 'infection': [825], '(8Luzza': [826], 'F.': [827, 841, 1109, 2558, 3220], 'Parrello': [828], 'Monteleone': [830], 'Sebkova': [832], 'Romano': [834], 'Zarrilli': [836], 'Imeneo': [838], 'Pallone': [840], 'Immunol.': [843, 888, 1244, 1293, 1329, 1344, 1423, 1481, 1561, 1639, 1692, 1714, 1921, 2007, 2104, 3280, 3677, 3922, 4151], '2000;': [844, 1345, 1424, 1640, 3439, 3678, 3892], '165:': [845, 1346], '5332-5337Crossref': [846], '(238)': [849], 'multiple': [852], 'sclerosis': [853], '(9Matusevicius': [854], 'Kivisakk': [856], 'He': [858], 'Kostulas': [860], 'Ozenci': [862], 'V.': [863], 'Fredrikson': [864], 'Link': [866], 'H.': [867, 883, 1159, 1419, 1635, 3673], 'Mult.': [868], 'Scler.': [869], '5:': [871], '101-104Crossref': [872], '(632)': [875], 'periodontal': [878], 'disease': [879], '(10Oda': [880], 'Yoshie': [882], 'Yamazaki': [884], 'K.': [885, 1005, 1011, 1037, 1373, 1415, 1599, 1631, 3669], 'Oral': [886], 'Microbiol.': [887], '18:': [890], '30-36Crossref': [891], '11Johnson': [897], 'R.B.': [898], 'Wood': [899], 'Serio': [901], 'F.G.': [902], 'Periodontol.': [904], '75:': [906], '37-43Crossref': [907], '(152)': [910], 'psoriasis': [914], '(12Teunissen': [915, 1201], 'M.B.': [916, 1202], 'Koomen': [917, 1203], 'C.W.': [918, 1204], 'de': [919, 1205, 1496, 1557], 'Waal': [920, 1206], 'Malefyt': [921, 1207], 'Wierenga': [923, 1209], 'E.A.': [924, 1210], 'Bos': [925, 1211], 'J.D.': [926, 1212], 'Invest.': [928, 1214], 'Dermatol.': [929, 1215], '1998;': [930, 1165, 1216], '111:': [931, 1217], '645-649Abstract': [932, 1218], 'Full': [933, 935, 1020, 1022, 1219, 1221, 1507, 1509, 1696, 1698, 1925, 1927, 2677, 2679, 3869], 'Text': [934, 936, 1021, 1023, 1220, 1222, 1508, 1510, 1697, 1699, 1926, 1928, 2678, 2680, 3870], 'PDF': [937, 1024, 1223, 1511, 1700, 1929, 2681, 3871], '(483)': [940, 1226], 'Mice': [943], 'IL-17R': [947], 'impaired': [951], 'recover': [954], 'Klebsiella': [956], 'pneumoniae': [957], '(13Ye': [959], 'Garvey': [961], 'P.B.': [962], 'Zhang': [963], 'Nelson': [965, 1288, 1476], 'Bagby': [967, 1286, 1474], 'Summer': [969], 'W.R.': [970], 'Schwarzenberger': [971], 'Shellito': [973, 1282, 1470], 'J.E.': [974, 1283, 1471], 'Am.': [977], 'Respir.': [979], '2001;': [980], 'C335-C340Google': [982], 'Similarly,': [984, 4273], 'IL-17-deficient': [985], 'mice': [986, 1435], 'exhibit': [987, 1523], 'hypersensitivity': [990], 'responses': [991], 'well': [993, 1357], 'other': [995, 1315, 1676, 3653], 'immune': [996, 2878, 2884, 2889], 'impairments': [997], '(14Nakae': [998], 'Komiyama': [1000], 'Y.': [1001, 1015, 1041, 1991, 2021, 3906, 4135], 'Nambu': [1002], 'Sudo': [1004, 1036], 'Iwase': [1006], 'Homma': [1008], 'I.': [1009], 'Sekikawa': [1010], 'Asano': [1012], 'Iwakura': [1014, 1040], 'Immunity.': [1016], '17:': [1018, 3629], '375-387Abstract': [1019], '(915)': [1027], '15Nakae': [1030], 'Saijo': [1032], 'Horai': [1034], 'Mori': [1038], 'Natl.': [1043, 2566], 'Acad.': [1044, 2567], 'Sci.': [1045, 2568], 'U.': [1046, 2569], '100:': [1050], '5986-5990Crossref': [1051], '(410)': [1054], 'Thus,': [1057, 3512, 3950, 4289], 'it': [1058], 'clear': [1060], 'plays': [1063], 'nonredundant': [1065], 'controlling': [1068], 'inflammation': [1069], 'settings.': [1074], 'Compared': [1075], 'with': [1076, 1571, 1782, 2270, 2474, 2580, 2746, 2757, 2765, 2780, 2788, 2841, 2848, 2869, 2875, 2904, 2931, 2969, 3029, 3046, 3115, 3386, 3389, 3463, 3573, 3580, 3583, 3592, 3652, 4034, 4051, 4238, 4243, 4278, 4347], 'extensive': [1078], 'IL-17,': [1085, 1590, 1664, 3038], 'considerably': [1086, 1198], 'less': [1087], 'expression.': [1094], 'In': [1095, 1250, 1353, 1661, 1867, 2041, 2127, 2748, 3382, 3728], 'mRNA': [1098], 'largely': [1100, 1659, 3647], 'CD4+': [1104, 1252], 'memory': [1105], '(16Fossiez': [1108, 3219], 'Djossou': [1110, 3221], 'O.': [1111, 3222], 'Chomarat': [1112, 3223], 'Flores-Romo': [1114, 3225], 'Ait-Yahia': [1116, 3227], 'Maat': [1118, 3229], 'C.': [1119, 1131, 1336, 1709, 2099, 3230, 3242, 3435], 'Pin': [1120, 3231], 'J.-J.': [1121, 3232], 'Garrone': [1122, 3233], 'Garcia': [1124, 3235], 'E.': [1125, 1136, 1275, 1279, 1417, 1463, 1467, 1633, 3236, 3247, 3671], 'Saeland': [1126, 3237], 'Blanchard': [1128, 3239], 'Gaillard': [1130, 3241], 'Das': [1132, 3243], 'Mahapatra': [1133, 3244], 'Rouvier': [1135, 3246], 'Golstein': [1137, 3248], 'Banchereau': [1139, 3250], 'Lebecque': [1141, 3252], 'Exp.': [1144, 3255], 'Med.': [1145, 3256], '1996;': [1146, 2674, 3257], '183:': [1147, 3258], '2593-2603Crossref': [1148, 3259], '(1251)': [1151, 3262], '17Shin': [1154], 'H.C.': [1155, 1174], 'Benbernou': [1156, 1175], 'Fekkar': [1158], 'Esnault': [1160, 1177], 'Guenounou': [1162, 1179], 'Cytokine.': [1164, 1181, 2118], '10:': [1166], '841-850Crossref': [1167], '(58)': [1170], '18Shin': [1173], '11:': [1183], '257-266Crossref': [1184], '(130)': [1187], 'CD8+': [1191, 1254], 'lower': [1199], '19Yao': [1229, 3265], 'Z.': [1230, 3266], 'Painter': [1231, 3267], 'Fanslow': [1233, 3269], 'W.C.': [1234, 1728, 2564, 2668, 3270], 'Ulrich': [1235, 3271], 'Macduff': [1237, 3273], 'B.M.': [1238, 3274], 'Spriggs': [1239, 3275], 'M.K.': [1240, 3276], 'Armitage': [1241, 3277], 'R.J.': [1242, 3278], '1995;': [1245, 1715, 2105, 2572, 3281], '155:': [1246, 3282], '5483-5486PubMed': [1247, 3283], 'mice,': [1251, 1520], 'produce': [1257, 1406], 'similar': [1258], 'upon': [1262, 3499], '(TCR)': [1269], '(20Happel': [1270, 1458], 'K.I.': [1271, 1459], 'Zheng': [1272, 1460], 'Young': [1274, 1462], 'Quinton': [1276, 1464], 'L.J.': [1277, 1465], 'Lockhart': [1278, 1466], 'Ramsay': [1280, 1468], 'A.J.': [1281, 1469], 'Schurr': [1284, 1472], 'J.R.': [1285, 1473], 'G.J.': [1287, 1475], '170:': [1295, 1483], '4432-4436Crossref': [1296, 1484], '(396)': [1299, 1487], 'Although': [1302, 3401], 'some': [1303, 4377], 'reports': [1304, 1316], 'indicate': [1305, 3132, 3788, 4189], 'made': [1309], 'Th0': [1311], 'Th1': [1313], 'implicate': [1317], 'Th2': [1318], '(21Aarvak': [1320], 'Chabaud': [1322], 'Miossec': [1324], 'Natvig': [1326], 'J.B.': [1327], '162:': [1331], '1246-1251PubMed': [1332], '22Infante-Duarte': [1335], 'Horton': [1337], 'H.F.': [1338], 'Byrne': [1339], 'M.C.': [1340], 'Kamradt': [1341], '6107-6115Crossref': [1347], '(477)': [1350], 'contrast': [1354, 1662, 2148], 'IL-2,': [1360], 'costimulation': [1362, 1778, 2153, 3114], 'only': [1363, 1524, 1542, 1763, 3118, 3405, 3484, 3506], 'mildly': [1364], 'enhances': [1365, 3120], 'production': [1367, 1454, 1532, 1546, 1588, 2137, 2160, 2995, 3065, 3563], 'mouse': [1369, 2150, 3109], 'primary': [1370, 3004, 3110, 3449, 3525], '2X.': [1372, 1598], 'Liu,': [1374, 1600], 'Clements,': [1377, 1603], 'Gaffen,': [1381, 1607], 'unpublished': [1382, 1608], 'data.': [1383, 1609], 'Under': [1384], 'vitro': [1386], 'conditions,': [1387], 'mitogen': [1389], '13-acetate': [1392], '(PMA)': [1393], 'IL-15': [1397], 'stimulate': [1402], '(23Ziolkowska': [1408, 1624, 3662], 'Koc': [1410, 1626, 3664], 'Luszczukiewicz': [1412, 1628, 3666], 'Ksiezopolksa-Pietrzak': [1414, 1630, 3668], 'Klimczak': [1416, 1632, 3670], 'Chwalinska-Sadowska': [1418, 1634, 3672], 'Maslinski': [1420, 1636, 3674], '164:': [1425, 1641, 3679], '2832-2838Crossref': [1426, 1642, 3680], '(523)': [1429, 1645, 3683], 'Furthermore,': [1432, 3753], 'lipopolysaccharide,': [1438], 'acting': [1439], 'Toll-like': [1441], 'receptor-4,': [1442], 'stimulates': [1443], 'dendritic': [1444, 1578], 'IL-23,': [1448], 'turn': [1451, 1849, 3996], 'triggers': [1452, 1889, 2154], '24Aggarwal': [1490], 'Ghilardi': [1492], 'Xie': [1494], 'M.H.': [1495], 'Sauvage': [1497, 1558], 'F.J.': [1498, 1559], 'Chem.': [1503, 2673], '278:': [1505], '1910-1914Abstract': [1506], '(1499)': [1514], 'IL-23-deficient': [1519], 'antigen-presenting': [1521, 1758, 1788], 'partially': [1526], 'diminished': [1527], 'capacity': [1528], 'trigger': [1530], 'indicating': [1536, 3718], 'IL-23': [1538, 1581], 'not': [1540, 2318, 3051, 3200, 3467, 3494, 3735, 3751, 3767, 3784, 3977, 4125, 4368, 4384, 4387], 'route': [1543], '(25Ghilardi': [1547], 'Kljavin': [1549], 'Chen': [1551, 3620], 'Q.': [1552], 'Lucas': [1553], '172:': [1563], '2827-2833Crossref': [1564], '(169)': [1567], 'Consistent': [1570], 'this,': [1572], 'recently': [1574, 1964, 4102], 'neither': [1577], 'nor': [1580], 'necessary': [1583, 1957, 1984, 4126], 'promoting': [1585], 'short': [1586], 'term': [1587], 'can': [1593, 4295], 'enhance': [1594], '∼2-fold.': [1597], 'Pharmacological': [1610], 'inhibitor': [1611, 3759], 'suggested': [1614], 'TCR-stimulated': [1616], 'calcineurin-': [1621], 'cAMP-dependent': [1623], 'precise': [1650], 'mechanism(s)': [1651], 'generate': [1656], 'unknown.': [1660], 'mechanisms': [1667, 2133], 'drive': [1673], 'such': [1678, 1853], 'IL-2': [1680, 1769, 1775, 1828, 2091, 3566], 'extensively': [1683], 'analyzed': [1684, 2286, 2522], '(26Kane': [1685], 'L.P.': [1686, 1915], 'Lin': [1687, 1916, 2004, 2024, 2028, 3919, 4148], 'Weiss': [1689, 1918, 3850, 3863], 'Trends': [1691, 1920], '23:': [1694, 1923], '413-420Abstract': [1695, 1924], '(159)': [1703, 1932], '27Jain': [1706, 2096], 'Loh': [1708, 2098], 'Rao': [1710, 2100, 3624], 'Curr.': [1712, 2102], 'Opin.': [1713, 2103], '7:': [1716, 2106], '333-342Crossref': [1717, 2107], '(500)': [1720, 2110], '28Gaffen': [1723], 'Goldsmith': [1725, 2561, 2669], 'Greene': [1727, 2563, 2667], 'Thomson': [1729], 'Handbook.': [1733], '3rd': [1734], 'Ed.': [1735], 'Academic': [1736], 'Press,': [1737], 'Ltd.,': [1738], 'London,': [1739], 'UK1998:': [1740], '73-103Google': [1741], 'TCR-CD3': [1744, 1760, 1834, 3939], 'complex': [1745, 1754, 1755, 1799, 1835, 1983, 2879, 2885, 2890], 'recognition': [1749], 'peptide-major': [1752], 'histocompatibility': [1753], 'cell.': [1759], 'alone': [1762, 3049], 'causes': [1764, 1803], 'relatively': [1765], 'small': [1766], 'amounts': [1767], 'be': [1771], 'released.': [1772], 'For': [1773, 2458, 2831], 'optimal': [1774], 'production,': [1776, 2177], 'further': [1777, 3147, 3459, 3827, 4313], 'interacting': [1781], 'B7–1': [1783], 'B7–2': [1785], 'required.': [1791], 'interactions': [1794], 'lead': [1795], 'highly': [1798, 3411, 3805], 'program,': [1801, 3333], 'import': [1805, 1905], 'several': [1807, 3557], 'transcription': [1809, 1825, 1908, 1949, 2063, 2088, 3343, 3613], 'factors,': [1810], 'including': [1811, 3014, 3351, 4006], '(NFAT),': [1818], 'NF-κB,': [1819, 2075, 3353], 'AP-1,': [1821, 3352], 'ultimately': [1823], 'Specifically,': [1830], 'engagement': [1831], 'leads': [1836, 1944], 'activation': [1838, 1946, 1960, 1987, 2057, 3791, 4113, 4129], 'tyrosine': [1841, 3932], 'kinases': [1842], 'ZAP-70,': [1843], 'p56-Lck,': [1844], 'Itk.': [1846], 'These': [1847, 3130, 3786, 4187, 4337], 'phosphorylate': [1850], 'adaptor': [1851], 'molecules': [1852, 1881, 1980], 'SLP76': [1855], 'LAT,': [1857], 'bind': [1859], 'recruit': [1862], 'various': [1863], 'enzymes.': [1866], 'particular,': [1868], 'phospholipase': [1869, 3982], 'Cγ1': [1870], '(PLCγ1)': [1871], 'becomes': [1872], 'phosphorylated,': [1873], 'leading': [1874, 2055], 'generation': [1876, 3986], 'second': [1879, 3084], 'messenger': [1880], '1,4,5-trisphosphate': [1883], '(IP3)': [1884], 'diacylglycerol': [1886], '(DAG).': [1887], 'IP3': [1888, 3086, 3991], 'rapid': [1890], 'Ca2+': [1891], 'release': [1892], 'intracellular': [1894], 'stores,': [1895], 'activates': [1897, 1936, 2048], 'phosphatase': [1899, 3602], 'calcineurin,': [1900, 3603], 'permitting': [1901], 'dephosphorylation': [1902], 'Ref.': [1913, 3617], '26Kane': [1914], 'DAG': [1935, 3088, 3989, 4054], 'C': [1939, 4110], 'pathways,': [1940], 'PKCθ,': [1942], 'NF-κB.': [1951, 1962], 'maximal': [1959], 'discovered': [1965], 'scaffold': [1973, 4104], 'CARMA1,': [1975], 'assembles': [1977], 'numerous': [1978], 'NF-κB': [1986, 4008, 4041, 4112], '(29Wang': [1988, 3903, 4132], 'You': [1990, 2020, 3905, 4134], 'Case': [1992, 3907, 4136], 'S.M.': [1993, 3908, 4137], 'McAllister-Lucas': [1994, 3909, 4138], 'L.M.': [1995, 3910, 4139], 'Wang': [1996, 3911, 4140], 'DiStefano': [1998, 3913, 4142], 'P.S.': [1999, 3914, 4143], 'Nunez': [2000, 3915, 4144], 'Bertin': [2002, 3917, 4146], 'X.': [2005, 2025, 2029, 2664, 3920, 4149], 'Nat.': [2006, 3921, 4150], '3:': [2009, 3924, 4153], '830-835Crossref': [2010, 3925, 4154], '(253)': [2013, 3928, 4157], '30Wang': [2016], 'Matsumoto': [2018], 'Che': [2022], 'Gaffen': [2026], 'Mol.': [2030, 3889], 'Cell.': [2031, 3865, 3890], '24:': [2034], '164-171Crossref': [2035], '(179)': [2038], 'addition,': [2042], 'c-Fos': [2060], 'c-Jun,': [2062], 'factors': [2064, 3344, 3614], 'together': [2066, 4242], 'comprise': [2067], 'AP-1': [2069, 2077, 2603, 3768, 3782], 'complex.': [2072], 'act': [2078, 4227], 'concert': [2080], 'IL-2-proximal': [2083], 'resulting': [2085, 2348], 'potent': [2087, 3095], '31Gaffen': [2114], 'Liu': [2116, 2663], 'K.D.': [2117], '28:': [2120], '109-123Crossref': [2121], '(335)': [2124], 'present': [2129], 'study,': [2130], 'TCR-induced': [2135], 'tissue': [2140], 'culture': [2141], 'model.': [2142], 'First,': [2143], 'that,': [2146], 'substantial': [2156], 'increase': [2157, 3394, 3403], 'calcineurin/NFAT': [2168], 'pathway': [2169, 3722], 'required': [2174, 3997], 'proximal': [2188], 'critical': [2192], 'TCR-mediated': [2194, 3790], 'Cell': [2201, 2707, 2814, 3165], 'Isolation,': [2202], 'Tissue': [2203], 'Culture,': [2204], 'ELISA—Peripheral': [2206], 'purchased': [2209, 2705], 'Biological': [2211], 'Specialty': [2212], 'Corp.': [2213], '(Colmar,': [2214], 'PA),': [2215], '(PBMCs)': [2221], 'Ficoll-Hypaque': [2225], '(Sigma)': [2226], 'gradient': [2227], 'centrifugation.': [2228, 2797, 2830], '106': [2229, 2752], 'cultured': [2232], '96-well': [2234], 'plates': [2235], 'presence': [2238, 2920, 2954], '(OKT3),': [2241], 'and/or': [2242, 4040], 'anti-CD28': [2243, 3047, 3061, 3116, 3464, 3469], '(Caltag': [2244], 'Laboratories,': [2245], 'Burlingame,': [2246], 'CA)': [2247], 'PMA/ionomycin': [2249, 2758, 3075, 3510], '(Biomol': [2250], 'International,': [2251], 'Plymouth': [2252], 'Meeting,': [2253], 'PA)': [2254], '24': [2256, 3025, 3070], '48': [2258, 3027, 3072], 'h.': [2259], 'maintained': [2265], 'RPMI': [2267, 2472], '1640': [2268, 2473], 'supplemented': [2269], '10%': [2271], 'fetal': [2272], 'bovine': [2273], 'serum': [2274], '(Gemini': [2275], 'Bioproducts,': [2276], 'Woodland,': [2277], 'CA),': [2278], '1%': [2279, 2766], 'penicillin/streptomycin,': [2280], 'l-glutamine': [2282], '(Invitrogen).': [2283], 'Supernatants': [2284], 'ELISA': [2290, 3042], 'per': [2291, 2594], "manufacturer's": [2293, 2744], 'instructions': [2294], '(BioSource': [2295], 'Europe': [2296], 'S.A.,': [2297], 'Nivelles,': [2298], 'Belgium).': [2299], 'PCR,': [2300], 'Plasmids,': [2301], 'Transfections,': [2302], 'Luciferase': [2304], 'Assays—The': [2305], 'point': [2308, 3193, 3209, 3310], 'determined': [2314, 3196], '5′-RACE': [2316, 3198], '(data': [2317, 3199, 3750, 4386], 'shown).': [2319, 3752, 3978, 4388], 'PCR': [2320, 2968, 3312], 'primers': [2321, 2355, 2970, 3313], 'designed': [2323], 'subclone': [2325], 'sequences': [2326, 2597, 4362], '1125': [2327], 'bp': [2328, 4366, 4393], 'site': [2334, 2622, 3331], 'base': [2344], '(NT_007592),': [2345], 'product': [2349], 'confirmed': [2351], 'sequencing.': [2353], 'Oligonucleotide': [2354], 'cloning': [2358], '(MWG': [2359], 'Biotech,': [2360], 'High': [2361], 'Point,': [2362], 'NC)': [2363], 'follows:': [2366], 'h17p(-1125)-Luc': [2367, 3516, 3837, 3953, 4240], '(5′-ACGCGTGGATCTCAGGACAAACAGGTTC-3′)': [2368], 'h17p-downstream': [2370], '(5′-AAGCTTGACTCACCACCAATGAGGTCTT-3′).': [2371], 'truncated': [2373], 'forms': [2374], 'using': [2380, 2730, 3311, 3426, 3691], 'primers:': [2383], 'h17p(-924)-Luc,': [2384], '5′-ACGCGTCCCTTCCTTGTCCTAGTCCTCT-3′;': [2385], 'h17p(-739)-Luc,': [2386], '5′-ACGCGTCTCCATCACCTTTGTCCAGTC-3′;': [2387], 'h17p(-352)-Luc,': [2388], '5′-ACGCGTGAGCATAACTCTTCTGGCAGC-3′;': [2389], 'h17p(-232)-Luc,': [2390], '5′-ACGCGTCATGAATTTCTGCCCTTCCC-3′;': [2391], 'h17p(-159)-Luc,': [2393], '5′-ACGCGTTAACCAAAATGGTGTCACCCC-3′.': [2394], 'All': [2395, 2431], 'into': [2398, 2429, 2822, 3841], 'pGL3-enhancer': [2400], 'vector': [2401], 'MluI': [2404], 'HindIII': [2406], '(Promega,': [2408], 'Madison,': [2409], 'WI).': [2410], 'h17p(TATA)-Luc': [2412], 'construct': [2413, 2441, 2451, 3482, 3517, 3838, 4241], 'annealing': [2417], 'oligonucleotides,': [2419], '5′-CGCGTAAGCCCTATAAAAAGAGA-3′': [2420], '5′-AGCTTCTCTTTTTATAGGGCTTA-3′,': [2422], 'creating': [2423], 'overhangs': [2424], 'allow': [2426], 'direct': [2427, 4218], 'subcloning': [2428], 'pGL3-enhancer.': [2430], 'enzymes': [2432], 'MBI': [2435], 'Fermentas': [2436], '(Hanover,': [2437], 'MD).': [2438], 'pSRα-NFATc1': [2440], 'Dr.': [2445, 2455], 'Colleen': [2446], 'Sheridan,': [2447], 'pCMV5-Ras': [2450], 'obtained': [2453, 2721], 'Warner': [2456], 'Greene.': [2457], 'transfections,': [2459], '1': [2460, 2864, 2937], '×': [2461, 2751], '107': [2462], 'triplicate': [2465], 'resuspended': [2467], '400': [2469], 'μl': [2470, 2799, 2851, 2906, 2923], '5–20': [2475], 'μg': [2476, 2481, 2582, 2834, 2957], 'plasmid,': [2479], '0–15': [2480], 'plasmids,': [2486], '20': [2488, 2922, 2956], 'ng': [2489], 'Renilla': [2492, 3968], 'luciferase': [2493, 2524, 3365, 3422, 3428, 3590, 3969, 4057, 4380], 'plasmid.': [2494], 'Cells': [2495, 2784], 'electroporated': [2497], '250': [2499, 2781], 'V,': [2500], '950': [2501], 'microfarads': [2502], 'GenePulser': [2505], 'electroporator': [2506], '(Bio-Rad).': [2507], 'Twenty-four': [2508], 'hours': [2509], 'later,': [2510], 'stimulated': [2513, 2756, 3579, 4346], '6': [2515], 'h': [2516, 2865, 2938, 3028], 'lysed,': [2518], 'supernatants': [2520], 'Orion': [2528], 'MPL2': [2529], 'luminometer': [2530], '(Berthold': [2531], 'Detection': [2532], 'Systems,': [2533], 'Oak': [2534], 'Ridge,': [2535], 'TN).': [2536], 'Immunoprecipitation,': [2538], 'Western': [2539, 2650], 'Blotting,': [2540], 'Chromatin': [2542], 'Immunoprecipitation': [2543], '(CHIP)': [2544], 'Assays—EMSAs': [2545], 'performed': [2547, 2653, 2729], '(32Gaffen': [2551], 'Lai': [2553, 2659], 'S.Y.': [2554, 2660], 'Xu': [2555], 'Gouilleux': [2557], 'Groner': [2559], '92:': [2573], '7192-7196Crossref': [2574], '(86)': [2577], 'Scholar)': [2579, 3285], '10': [2581, 2810, 2932], 'extract': [2585], '105': [2587], 'cpm': [2588], '32P-labeled': [2590], 'double-stranded': [2591], 'oligonucleotide': [2592, 2604], 'probe': [2593], 'sample.': [2595], 'wild-type': [2600], 'probes': [2605], 'follows': [2608], '(top': [2609], 'strand': [2610], 'only):': [2611], '5′-CGCCCAAAGAGGAAAATTTGTTTCATA-3′': [2612], '5′-CGCTTGATGAGTCAGCCGGAA-3′.': [2614], 'mutant': [2616], '5′-CGCCCAAAGCTTAAAATTTGTTTCATA-3′': [2620], '(mutation': [2621], 'underlined).': [2623], 'anti-NFAT': [2625], 'Abs': [2626, 2687, 2712, 3016, 3031, 3048, 3117, 3128, 3391, 3465, 3582, 4349], '(sc-1149),': [2627], 'anti-NFATc1': [2628, 2836], '(sc-7394),': [2629], 'anti-NFATc2': [2631], '(sc-7296)': [2632], 'isotype-matched': [2635], 'nonspecific': [2636, 3738], 'Ab': [2637], 'supershifting': [2640], 'Santa': [2643, 2723], 'Cruz': [2644, 2724], 'Biotechnology,': [2645, 2737], 'Inc.': [2646, 2709], '(Santa': [2647], 'Cruz,': [2648], 'CA).': [2649], 'blotting': [2651], '(33Gaffen': [2657], 'Ha': [2661], 'Hennighausen': [2665], '271:': [2675], '21381-21390Abstract': [2676], '(68)': [2684], 'phosphorylated': [2689, 2693, 2714], 'JNK': [2690, 2697, 3697], '(Ab': [2691, 2695, 2698, 2702], '9251),': [2692], 'p38': [2694, 2701], '9211),': [2696], '9252),': [2699], '9212)': [2703], 'Signaling': [2708, 3532], '(Beverly,': [2710], 'MA).': [2711], 'ERK': [2715, 2718, 3775], '(sc-7383)': [2716], '(sc-154)': [2719], 'Biotechnology.': [2725], 'CHIP': [2726], 'assay': [2734], 'kit': [2735], '(Upstate': [2736], 'Inc.,': [2738], 'Lake': [2739], 'Placid,': [2740], 'NY),': [2741], 'protocol': [2745], 'modifications.': [2747], 'brief,': [2749], '5': [2750, 2925], '30': [2760, 2850], 'min': [2761, 2772, 2811, 2897], 'then': [2763, 2873, 3588], 'fixed': [2764], 'formaldehyde': [2767], '(final': [2768], 'concentration)': [2769], '15': [2771], 'room': [2774], 'temperature.': [2775], 'Cross-linking': [2776], 'reactions': [2777], 'quenched': [2779], 'μm': [2782], 'glycine.': [2783], 'briefly': [2786], 'lysated': [2787], '0.4%': [2789], 'Nonidet': [2790], 'P-40,': [2791], 'nuclei': [2793, 2808], 'collected': [2795], '200': [2798], 'SDS': [2801], 'lysis': [2802], 'buffer': [2803], 'added': [2805, 2860], 'ice.': [2813], 'lysates': [2815, 2843], 'sonicated': [2817], 'shear': [2819], '200–500-bp': [2823], 'fragments,': [2824], 'debris': [2826], 'removed': [2828], 'immunoprecipitation,': [2832], '2': [2833], 'anti-IgG1': [2838], 'incubated': [2840, 2862], 'overnight': [2844, 2917], '4': [2846, 2867], '°C': [2847, 2868, 2916], 'rotation.': [2849, 2870], 'Protein': [2853], 'G': [2854], 'beads': [2855], '(Roche': [2856, 2960], 'Applied': [2857, 2961], 'Science)': [2858], 'Beads': [2871], 'washed': [2874], 'low': [2876], 'salt': [2877, 2883], 'wash': [2880, 2886, 2891], 'buffer,': [2881, 2887, 2892, 2909], 'high': [2882, 3419], 'LiCl': [2888], 'TE': [2894], '3–5': [2896], 'sequence.': [2899], 'DNA-protein': [2900], 'complexes': [2901], 'eluted': [2903], '500': [2905], 'elution': [2908], 'cross-links': [2911], 'reversed': [2913], '65': [2915], 'm': [2926], 'NaCl.': [2927], 'Proteins': [2928], 'digested': [2930], 'mg/ml': [2933], 'proteinase': [2934], 'K': [2935], '45': [2940], '°C,': [2941], 'recovered': [2945], 'phenol/chloroform': [2947], 'extraction': [2948], 'ethanol': [2950], 'precipitation': [2951], 'glycogen': [2959], 'Science).': [2962], 'Specific': [2963], 'amplified': [2966], 'spanning': [2971], '+34': [2974], 'Human': [2979, 3163], 'Is': [2981, 3159], 'Produced': [2982], 'Primary': [2984], 'Lymphocytes': [2985], 'Stimulated': [2986], 'TCR—Since': [2989], 'signals': [2991, 4002, 4016, 4078], 'regulate': [2993], 'remain': [2996, 4082], 'poorly': [2997], 'defined,': [2998], 'PBMCs': [3006, 3033], 'response': [3008, 4171], 'standard': [3010], 'stimuli,': [3013], 'agonistic': [3015], 'CD28.': [3020], 'Upon': [3021], 'alone,': [3032], 'secreted': [3034], 'detectable': [3035], 'assessed': [3040, 3553], '(Fig.': [3043, 3399, 3649, 3705, 3769, 3963, 4071, 4185, 4271, 4335, 4350, 4356], '1).': [3044], 'Stimulation': [3045], 'did': [3050, 3493, 4367], 'markedly': [3062, 4369], '(2.5-': [3066], '4-fold': [3068], 'h,': [3073], 'respectively).': [3074], 'treatment,': [3076], 'bypasses': [3078], 'mimicking': [3082], 'messengers': [3085], 'produced': [3089], 'PLCγ1,': [3091], 'resulted': [3093], 'pattern': [3099], 'strikingly': [3103], 'different': [3104, 3214], 'observed': [3107, 3425, 4029], 'weakly': [3119], 'above': [3123], 'alone.2': [3129], 'results': [3131, 3326], 'stimulation': [3140, 3388, 3962, 4050, 4270], 'increases': [3148], '1-kb': [3152], 'Region': [3153], 'Upstream': [3154], 'Gene': [3158], 'Biologically': [3160], 'Active': [3161], 'Lines—The': [3166], 'most': [3169], 'cell-derived': [3171], 'regulated': [3174], 'part': [3178], 'initiation': [3181], 'transcription.': [3183], 'explore': [3185], 'transcription,': [3189], 'Fig.': [3203], '2A).': [3204], 'slightly': [3213, 3507], 'those': [3216], 'reported': [3218], '51': [3289], 'bases': [3290], 'downstream': [3291, 4017, 4079], 'TATA': [3294, 3486], 'box.': [3295], 'Next,': [3296], '∼1.2': [3299], '5′-flanking': [3302, 4361], 'information': [3317], 'base.': [3323], 'According': [3324], 'AliBaba2.1': [3329], 'prediction': [3332], 'contained': [3336], 'number': [3341], 'frequently': [3345], 'implicated': [3346], 'subcloned': [3361], '(termed': [3368], 'h17p(-1125)-Luc),': [3369, 3578], 'line.': [3381], 'transfected': [3385, 3570, 3840], 'h17p(-1125)-Luc,': [3387], 'caused': [3392], '2B).': [3400], '2-fold,': [3407], 'finding': [3409], 'reproducible': [3412, 4385], 'probably': [3415, 4196], 'attributable': [3416], 'background': [3420], 'commonly': [3424], 'pGL3-based': [3427], 'vectors': [3429], '(34Bert': [3430], 'Burrows': [3432], 'Osborne': [3434], 'Cockerill': [3436], 'Plasmid.': [3438], '44:': [3440], '173-182Crossref': [3441], '(55)': [3444], 'Similar': [3447], 'alone.': [3470], 'induction': [3472], 'because': [3480], 'containing': [3483], 'box': [3487], 'derived': [3488], 'hIL-17': [3491, 4026, 4162, 4204, 4230, 4280, 4371], 'CD3/CD28': [3502, 4119], 'stimulation.': [3511], 'appears': [3518], 'mirror': [3520], 'Calcineurin/NFAT': [3529], 'Pathways': [3533], 'Are': [3534, 4305], 'Involved': [3535], 'Production—As': [3538], 'initial': [3540], 'step': [3541], 'exploring': [3543], 'potential': [3544], 'involved': [3547, 3724, 3831], 'effects': [3555, 3733], 'pharmacological': [3558], 'inhibitors': [3559, 3693, 3776], 'block': [3562], 'IL-17.': [3568], 'We': [3569], '(i.e.': [3577, 4397], 'anti-CD3/anti-CD28': [3581, 4348], 'without': [3585], 'inhibitors,': [3586], 'compared': [3589], 'mock-treated': [3593], 'samples.': [3594], 'Cyclosporin': [3595], '(CsA)': [3597], 'acts': [3598, 3935], 'blocking': [3600], 'responsible': [3606, 3983], 'activating': [3608], '35Hogan': [3618], 'P.G.': [3619], 'Nardone': [3622], 'Genes': [3626], 'Dev.': [3627], '2205-2232Crossref': [3630], '(1557)': [3633], 'At': [3636], 'dose': [3638], '100': [3640], 'nm': [3641], 'blocked': [3648, 3712, 3761, 3778], '3A),': [3650], 'consistent': [3651, 4033], 'work': [3654], 'implicates': [3656], 'calcineurin': [3657, 3794], 'Scholar).2': [3685], 'Subsequently,': [3686], 'SP600125': [3694, 3715], '(which': [3695, 3702], 'blocks': [3696, 3703], 'p38)': [3699], 'PD98059': [3701], 'ERK)': [3704], '3B).': [3706], 'Reporter': [3707], 'PD98059,': [3717], 'regulation.': [3727], 'all': [3729, 3742, 3947, 4015], 'cases,': [3730], 'inhibitory': [3732], 'due': [3736], 'cellular': [3739], 'toxicity,': [3740], 'since': [3741], 'equally': [3745], 'viable': [3746], 'throughout': [3747], 'experiment': [3749, 4075], 'EMSA': [3755], 'experiments,': [3756], 'CsA': [3758], 'specifically': [3760, 3777, 3818], '3C).': [3770], 'Conversely,': [3771], 'JNK/p38': [3773], 'valuable': [3806], 'feature': [3807], 'line': [3812], 'availability': [3815], 'subclones': [3817], 'defective': [3819, 3844], 'particular': [3821], 'intermediates.': [3824], 'Therefore,': [3825], 'p56-Lck': [3846, 3934], '(JCaM1.6': [3847], '(36Goldsmith': [3848], 'Science.': [3852], '1988;': [3853], '240:': [3854], '1029-1031Crossref': [3855], '(140)': [3858], '37Straus': [3861], 'D.B.': [3862], '1992;': [3866], '70:': [3867], '585-593Abstract': [3868], '(935)': [3874], 'Scholar)),': [3876, 3899], 'PLCγ1': [3877, 3979, 4045, 4081, 4091], '(Jγ1': [3878], '(38Irvin': [3879], 'B.J.': [3880], 'Williams': [3881], 'B.L.': [3882], 'Nilson': [3883], 'A.E.': [3884], 'Maynor': [3885], 'H.O.': [3886], 'Abraham': [3887], 'R.T.': [3888], '20:': [3893], '9149-9161Crossref': [3894], '(113)': [3897], 'CARMA1': [3901, 4099, 4123], '(JPM50.6': [3902], 'Scholar)).': [3930], 'early': [3936], 'cascade': [3941], 'lies': [3943, 4092], 'nearly': [3946], 'CD3-dependent': [3948], 'signals.': [3949], 'expected,': [3952], 'displayed': [3954], 'no': [3955], 'Lck(-)': [3958], '4A)': [3964], '(whereas': [3965], 'internal': [3967], 'control': [3970, 4074], 'expressed': [3972], 'normal': [3974], 'levels;': [3975], 'messengers,': [3992], 'PKCθ-': [3999], 'calcium-dependent': [4001], 'Consequently,': [4011], 'Jγ1': [4013], 'PLCγ': [4019], 'absent.': [4021], 'No': [4022], 'PLCγ1(-)': [4031], 'pathways.': [4042], 'when': [4044, 4274], 'bypassed': [4048], 'PMA': [4052, 4353], '(a': [4053], 'analog),': [4055], 'restored': [4060], 'equivalent': [4063], 'wild': [4067, 4232], 'type': [4068, 4233], '4B).': [4072], 'indicated': [4076], 'intact': [4083], 'Finally,': [4098], 'molecule': [4105], 'mediates': [4107], '(PKC)-θ-induced': [4111], 'hence': [4115], 'costimulation.': [4120], 'Notably,': [4121], 'however,': [4122], 'CD3-mediated': [4128], 'Whereas': [4160], 'fully': [4165], 'CARMA1(-)': [4168], 'contribution': [4176, 4192, 4209], 'eliminated': [4184], '4A).': [4186], 'via': [4197], 'clearly': [4201], 'whereas': [4207], 'depends': [4212], 'CARMA1.': [4214], 'obtain': [4216], 'more': [4217], 'indeed': [4226], 'co-transfected': [4237, 4277], '5-fold': [4245], 'excess': [4246], '(to': [4249], 'pathways)': [4252], 'NFATc1.': [4254], 'marked': [4258], 'stimulatory': [4259], 'effect': [4260], 'basal': [4266], 'after': [4269, 4394], '4C).': [4272], 'promoter-luciferase': [4281], 'construct,': [4282], 'transactivate': [4296], 'Two': [4300], 'Functional': [4301], 'Binding': [4303], 'Sites': [4304], 'Located': [4306], 'Minimal': [4309], 'Regulatory': [4311], 'Region—To': [4312], 'regulatory': [4316], 'end': [4331], '5A).': [4336], 'constructs': [4338], 'assayed': [4340], 'function': [4342], '5B)': [4351], 'ionomycin': [4355], '5C).': [4357], 'Deletions': [4358], 'up': [4363], 'until': [4364], 'reduce': [4370], 'function,': [4373], 'there': [4375], 'variability': [4378], 'deletion': [4390], '73': [4392], 'position': [4395]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2013507458', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 12}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2025-01-06T03:51:50.676243', 'created_date': '2016-06-24'}
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