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635, 674, 965, 1130, 1245, 1296, 1549, 1572, 1616, 1732, 2919, 2932, 3061], 'importance': [223, 713], 'many': [227], 'physiological': [228], 'pathways': [229], 'ubiquitous': [232], 'distribution': [233, 379], 'throughout': [234], 'body': [236], 'led': [237], 'nomination': [240], 'molecule': [243, 1733], 'year': [246], '1992.6': [248], 'An': [249], 'extensive': [250], 'identified,': [257], 'they': [259, 320, 328, 802, 827, 843], 'be': [261, 416, 618, 908, 921, 960, 1128, 1279, 1346, 1462, 1479, 1570], 'subdivided': [262], 'isoforms': [264], 'are': [266, 272, 361, 671, 1256, 1578, 1973], 'expressed': [267, 1449, 1574], 'constitutively': [268, 1448], 'those': [270, 1581], 'evident': [273], 'only': [274, 1082], 'after': [275, 2137, 2437, 2801, 2929], 'induction.': [276], 'latter': [282], 'group': [283, 796], 'is': [284, 291, 350, 366, 382, 392, 440, 460, 502, 516, 525, 530, 572, 609, 684, 730, 879, 931, 1091, 1147, 1182, 1185, 1301, 1319, 1368, 1370, 1403, 1439, 1447, 1452, 2704, 2886], 'often': [285], 'cytotoxicity,': [288], 'part': [294], 'very': [297, 1314], 'quantities': [299], 'synthesized': [300], 'inducible': [303], 'enzyme': [304, 307, 535, 1049, 1067], 'systems.7': [305], 'Both': [306], 'types': [308, 481], 'cloned': [311, 583], 'species': [316], 'tissues,': [318], 'share': [321], 'common': [322, 793, 859], 'features': [323, 791, 857], 'l-arginine': [331, 347, 1488], '(see': [332], 'References': [333, 1610], '4': [334, 2636, 2646], '7': [336], 'reviews).': [338], 'conversion': [340, 454, 889], 'one': [342, 871], 'guanidinonitrogens': [345], 'oxidation': [352, 901, 2638], 'process': [353], 'involving': [354], 'five': [355], 'electrons,': [356], 'two': [358, 1236], 'these': [360, 745, 1492], 'derived': [362], 'BH4.7': [364], 'normal': [368, 1177], 'cofactor': [369, 732, 1102, 1999, 2834, 2923], 'called': [375], 'monooxygenases.4': [376], 'tissue': [378, 1273], 'consistent': [383], 'sites': [386, 830], 'monooxygenase': [388, 764], 'activity,': [389, 719], 'there': [391], 'little': [393], 'information': [394], 'available': [395], 'levels': [398, 552, 1255, 1391, 1430], 'cells': [404, 501, 592, 659, 683, 1621], '(endothelial': [405], 'smooth': [407, 420, 499, 707, 1025, 1627, 1794, 1828, 1899], 'muscle)': [408], 'vessel': [412], 'wall.8': [413], 'cannot': [415], 'detected': [417], 'cultured': [419, 498, 591, 679, 1827, 1944], 'muscle': [421, 500, 708, 1628, 1795, 1829, 1900], 'cells,': [422], 'induction': [424, 533, 586, 639, 1018], 'cytokines': [429, 598, 623, 656, 1972], 'requires': [430, 1098], 'de': [431, 445], 'novo': [432, 446], 'synthesis': [433, 536, 1674, 1854], 'pterin.910': [436], 'Guanosine': [437], 'triphosphate': [438, 459], '(GTP)': [439], 'precursor': [442], 'biosynthesis': [447, 1942], 'first': [452, 881], 'step': [453, 882], 'GTP': [456, 463, 487, 493, 547, 578, 628, 668, 691, 695, 1020, 1542, 1916, 2464, 2753], 'dihydroneopterin': [458], 'catalyzed': [461, 761, 883], 'cyclohydrolase': [464, 488, 494, 548, 629, 669, 696, 1021, 1543, 1824, 1917, 2465], 'I': [465, 495, 549, 670, 1544, 1918, 2755], '3.5.4.16;': [467], 'Reference': [468, 1353], '9).': [469], 'Cytokines': [470], 'induce': [472, 483, 625, 652, 1976], 'robust': [473], 'several': [478, 655], 'different': [479, 1307, 1315], 'cell': [480, 1293, 1444, 1852, 2597], 'also': [482, 517, 1247], 'expression': [485, 491, 626, 653, 689, 1825], 'I.1011': [489], 'Rapid': [490], 'mRNA': [496, 1022, 3000], 'elicited': [503, 1217], 'activation': [505, 539, 544, 1884], 'adenylyl': [507, 1886], 'cyclase': [508, 1887], 'or': [509, 537, 1159, 1282, 1585], 'analogues': [511], 'cAMP.12': [513], 'Enzyme': [514, 1084], 'activity': [515, 697, 982, 1106, 1648], 'increased': [518], 'elevation': [520], 'cAMP,13': [522], 'it': [524, 742, 1557], 'not': [526, 1061, 1183, 1386, 1404, 1579, 2007], 'clear': [527], 'if': [528, 1066], 'existing': [541, 546], 'enzyme.': [542], 'Intuitively,': [543], 'elevated': [551, 1007], 'cAMP': [554], 'could': [555, 907], 'involve': [556], 'phosphorylation': [557, 571], 'cAMP-dependent': [559], 'protein': [560, 1889, 1984], 'kinase': [561, 569, 1890], '(A': [562], 'kinase).': [563], 'However,': [564, 1065, 1200, 1337, 1501], 'consensus': [566], 'sequence': [567, 807, 1131], 'A': [570, 611, 2187, 2192, 2247, 2501, 2588, 2740, 2989], 'absent': [573], 'all': [575], 'mammalian': [577], 'cyclohydrolases': [579], 'date.14The': [585], 'response': [594], 'single,': [596], 'individual': [597], 'yielded': [600], 'conflicting': [601], 'results': [602, 1029, 2632], 'suggesting': [603], 'combination': [606], 'molecules': [608, 1237], 'required.15': [610], 'possible': [612, 1471, 2888], 'explanation': [613, 1472], 'controversy': [616], 'inability': [620], 'conjunction': [631], 'synthase.': [634, 1199, 1295], 'efficacy': [636], 'endotoxin': [638], 'production,': [642, 1436], 'typically': [643], 'sepsis,': [646], 'reflect': [648], 'ability': [650], 'target': [658], 'thus': [661], 'ensure': [662], 'both': [664], 'subsequently': [672], 'coexpressed.': [673], 'murine': [680], 'endothelial': [682, 1276, 1292, 1443, 1620, 1676, 1718, 1851, 2561, 2641, 2844], 'dependent': [685], 'prior': [688], 'cyclohydrolase.3': [692], 'Inhibition': [693, 3120], 'DAHP': [699, 1419], 'attenuates': [700], 'IL-1': [705], 'β–treated': [706], 'cells.910These': [709], 'establish': [711], 'mechanism': [722], 'involvement': [725], 'remains': [726, 919, 1126], 'unresolved.': [727], 'Since': [728, 850, 1442], 'catalysis': [735, 940], 'mediated': [736], 'monooxygenase,': [738], 'role': [740, 971, 1118, 1359, 1556, 1618, 2265, 2356], 'plays': [743, 1357, 1558], 'conceivably': [748], 'offer': [749], 'insight': [750, 2197], 'contribution': [753], 'catalysis.': [757], 'reaction': [760], 'phenylalanine': [765], 'hydroxylase,': [766], 'contributes': [768, 774], 'hydroxylation': [770, 777, 869], 'chemistry.': [771], 'Also,': [772, 1012], 'biopterin': [773, 1768], 'substrates': [779], 'fatty': [782], 'acid': [783], 'monooxygenases.': [784], 'exhibit': [787, 1104], 'enzymes,': [798], 'addition,': [801], 'show': [803], 'some': [804], 'degree': [805], 'homology': [808, 1132], 'cytochrome': [811, 839, 1137], 'P-450': [812, 840, 861, 1138, 1163], 'reductase': [813, 1139, 1164, 1687, 1921], 'family.': [814], 'Purification': [815], 'sources': [823], 'indicated': [825], 'possess': [828], 'binding': [829], 'NAHPH,': [832], 'FMN,': [833], 'FAD': [835], 'similar': [836, 1105], 'reductases,': [841], 'contain': [844], 'iron-protoporphyrin': [846], 'IX': [847], 'prosthetic': [848], 'group.4': [849], 'reductases': [862], 'monooxygenases,': [864], 'facilitate': [867], 'amidine': [874], 'nitrogens': [875], 'This': [878, 896, 916], 'arginine': [891], 'citrulline.': [895], 'would': [897], 'result': [898], 'pterin,': [904], 'which': [905, 1027, 1328, 1364], 'then': [906], 'recycled': [909, 933], 'through': [910], 'flavin': [912], 'nucleotides': [913], 'via': [914], 'NADPH.': [915], 'attractive': [917], 'hypothesis': [918], 'proven;': [922], 'specific': [923], 'studies': [924, 944, 974], 'address': [926], 'suggest': [928, 945, 1230, 1410], 'neither': [932], 'solution': [935], 'nor': [936], 'consumed': [937], 'during': [938], 'process.16A': [941], 'bound': [947, 1453], 'stabilizes': [949], 'dimeric': [951], 'peptide': [952, 1080], 'structure': [953, 1701], 'synthases,': [956], 'mode': [962], 'action.': [964], 'most': [966, 1320], 'compelling': [967], 'evidence': [968], 'comes': [972], 'depression': [977], 'cytokine-induced': [979, 1788], 'transforming': [984, 2045], 'growth': [985, 1014, 2046], 'factor-β': [986], '(TGFβ).': [987], 'Induction': [988, 3154], 'interferon-γ': [993], '(INF-γ)': [994], 'mouse': [996], 'peritoneal': [997], 'macrophages': [998], 'was': [999, 1068, 1081, 1206], 'depressed': [1000], 'TGFβ': [1002], 'consequence': [1005], 'proteolysis': [1008], 'enzyme.17': [1011], 'suppressed': [1016], 'cytokine-treated': [1024], 'muscle,': [1026], 'presumably': [1028, 1180], 'reduced': [1031, 1323, 1765], 'production.10': [1033], 'presence': [1039, 1112, 1143, 2709], 'exhibited': [1042], '1:1': [1044], 'stoichiometry': [1045], 'respect': [1047], 'pterin.': [1052], 'Addition': [1053], 'exogenous': [1055, 1101], 'such': [1058, 1226], 'preparations': [1059, 1108], 'did': [1060, 1385], 'enhance': [1062], 'enzymatic': [1063], 'activity.': [1064, 1165], 'ratio': [1076], 'pterin': [1078, 1146], '0.2:1.4': [1083], 'less': [1092], 'stable': [1093], 'freeze-thaw': [1095], 'cycles': [1096], 'addition': [1099, 1518], 'obtained': [1109], 'pterin.12Clearly,': [1115], 'exact': [1117], 'clarified.': [1129], 'between': [1133, 1538], 'suggests': [1140, 1379], 'contrast': [1155], 'superoxide': [1157, 1332], 'anions': [1158], 'peroxides': [1160], 'demonstrate': [1169], 'relaxation': [1171, 1624], 'arteries,': [1175], 'under': [1176, 1201, 1251, 1303, 1491, 2295], 'conditions': [1178, 1202, 1252], 'where': [1179, 1203, 1253, 1562], 'lacking,': [1184], 'sensitive': [1186], 'inhibition': [1188], 'NG-nitro-l-arginine': [1190], 'methyl': [1191], 'ester': [1192], '(L-NAME),': [1193], 'established': [1195], 'attenuated': [1207], 'DAHP,': [1209], 'L-NAME': [1210], 'had': [1211], 'effect': [1213], 'relaxations': [1216, 1507], 'calcium': [1220], 'ionophore': [1221], 'A23187,': [1222], 'catalase': [1224], 'abolished': [1225], 'These': [1228], 'data': [1229, 1409], 'provide': [1235], 'responsible': [1238, 1347], 'vasorelaxation': [1240], 'beds.': [1244], 'authors': [1246, 1503], 'point': [1248], 'out': [1249], 'suboptimal,': [1257], 'lead': [1266], 'hydroxyl': [1268], 'radical': [1269], 'oxidative': [1272], 'damage.': [1274], 'Therefore,': [1275], 'dysfunction': [1277, 1716, 2700], 'caused': [1283], 'potential': [1287], 'harmful': [1288], 'oxidizing': [1289], 'agents': [1290], 'redox': [1297, 1377], 'state': [1298], 'currently': [1302], 'close': [1304, 1536], 'scrutiny,': [1305], 'forms': [1308, 1339, 1766], 'same': [1311], 'entity': [1312], 'having': [1313], 'biological': [1316, 1647, 1770], 'effects.': [1317], 'likely': [1321], 'form': [1324, 1335, 1365], '(NO·),': [1327], 'interact': [1330], 'anion': [1333], 'peroxynitrite.18': [1336], 'other': [1338, 1560], '(NO+': [1342], 'NO−)': [1344], 'vasodilation': [1349], '(for': [1350], 'review,': [1351], 'see': [1352], '18).': [1354], 'Whether': [1355], 'any': [1358], 'produced': [1369, 2701], 'unknown,': [1371], 'complexity': [1374], 'possibility.': [1381], 'attempt': [1387], 'measure': [1389], 'tissues': [1396, 1414, 1483, 1512, 1561, 1771], 'used': [1397], 'their': [1399, 1527], 'experiments,': [1400], 'trivial': [1406], 'task.': [1407], 'Their': [1408], 'incubation': [1412, 1481], '6': [1416], 'hours': [1417], '(to': [1420], 'inhibit': [1421, 1982], 'synthesis)': [1423], 'leads': [1424, 1484], 'sufficient': [1426], 'reduction': [1427], 'impair': [1434], 'generated': [1440], 'instead.': [1441], 'enzyme,': [1456], 'turnover': [1457], 'required': [1463, 1974], 'deplete': [1465], 'system': [1467], 'biopterin.': [1469], 'Another': [1470], 'substrate,': [1489], 'conditions,': [1493], 'reduces': [1496, 2925], 'O2': [1497], 'peroxide.18': [1500], 'demonstrated': [1504, 1533], 'NO-dependent': [1506], 'restored': [1509], 'BH4-depleted': [1511], '(incubation': [1513], 'DAHP)': [1515], 'just': [1516], '6-methyl-tetrahydrobiopterin,': [1520], 'liposoluble': [1522], 'analogue': [1523], 'article,': [1528], 'relation': [1537, 1553], 'exists': [1545], 'endothelium.': [1548], 'extent': [1550], 'what': [1555], 'exerts': [1564], 'important': [1565], '(patho)physiological': [1566], 'effects': [1567], 'remain': [1568], 'investigated.': [1571], 'opinions': [1573], 'editorial': [1577], 'necessarily': [1580], 'editors': [1584], 'American': [1588, 2359, 2713, 2846, 3190], 'Association.': [1590], 'FootnotesCorrespondence': [1591], 'Dr': [1593], 'Scott-Burden,': [1594], 'PO': [1602], 'Box': [1603], '20345,': [1604], 'MC': [1605], '2-255,': [1606], 'TX': [1608], '77225-0345.': [1609], '1': [1611, 2466, 2524, 3182], 'RF,': [1613], 'Zawadzki': [1614], 'JV.': [1615], 'obligatory': [1617], 'arterial': [1626], 'acetylcholine.': [1630], 'Nature.1980;': [1631], '288:373-376.': [1632], 'CrossrefMedlineGoogle': [1633, 1655, 1694, 1708, 1727, 1740, 1777, 1801, 1836, 1871, 1931, 1955, 1989, 2025, 2053, 2071], 'Scholar2': [1634], 'RMJ,': [1636], 'Ferrige': [1637], 'AG,': [1638], 'Moncada': [1639], 'S.': [1640, 1996], 'release': [1643, 2043], 'accounts': [1644], 'factor.': [1652, 1865], 'Nature.1987;': [1653], '327:524-526.': [1654], 'Scholar3': [1656], 'Schoedon': [1657, 1838, 2784, 2916, 2948, 2991, 3107], 'G,': [1658, 1664, 1839, 2312, 2376, 2779, 2949, 3108], 'Blau': [1659, 1842, 3109], 'N,': [1660, 1843, 2148, 2334, 2863, 2865, 2873], 'Schneemann': [1661, 1840], 'M,': [1662, 1841, 1934, 2111, 2119, 2237, 2738, 2783, 2869, 3043, 3077], 'Flury': [1663], 'Schaffner': [1665, 1846, 2911, 2958, 2988], 'A.': [1666, 1847], 'depends': [1670], 'preceding': [1672], 'cells:': [1677], 'selective': [1678], 'suppression': [1679, 2039], 'induced': [1681], 'sepiapterin': [1686], 'inhibitors.': [1688], 'Biochem': [1689, 1831, 1866], 'Biophys': [1690, 1832, 1867], 'Res': [1691, 1833, 1868], 'Commun.1994;': [1692], '199:504-510.': [1693], 'Scholar4': [1695], 'Marletta': [1696], 'MA.': [1697], 'mechanism.': [1703], 'J': [1704, 1797, 1927, 1951, 2049, 2390, 2429, 2462, 2555, 2628, 3148], 'Biol': [1705, 1798, 1952], 'Chem.1993;': [1706], '268:12231-12234.': [1707], 'Scholar5': [1709], 'F,': [1711, 2109, 2379, 2867], 'Katušić': [1712], 'ZS.': [1713], 'arteries.': [1724], 'Circulation.1995;': [1725], '91:139-144.': [1726], 'Scholar6': [1728], 'Koshland': [1729], 'DE': [1730], 'Jr.': [1731], 'year.': [1736], 'Science.1992;': [1737, 2069], '258:1861.': [1738], 'Abstract.': [1739], 'Scholar7': [1741], 'Stuehr': [1742, 1961], 'DJ,': [1743, 1962, 2058], 'Griffith': [1744], 'OW.': [1745], 'Mammalian': [1746], 'synthases.': [1749], 'Adv': [1750], 'Enzymol': [1751], 'Relat': [1752], 'Areas': [1753], 'Mol': [1754, 1902], 'Biol.1992;': [1755], '65:287-346.': [1756], 'MedlineGoogle': [1757, 1905], 'Scholar8': [1758], 'Fukushima': [1759], 'T,': [1760, 1804, 1808, 1874, 1878, 2083, 2113, 2152, 2283, 2285, 2336, 3041, 3073, 3142], 'Nixon': [1761], 'JC.': [1762], 'Analysis': [1763], 'fluids.': [1773], 'Anal': [1774], 'Biochem.1980;': [1775], '102:176-188.': [1776], 'Scholar9': [1778], 'Gross': [1779], 'SS,': [1780], 'Levi.': [1781], 'synthesis:': [1783], 'absolute': [1785], 'requirement': [1786], 'generation': [1791], 'cells.': [1796, 1830, 1901, 1926], 'Chem.1992;': [1799], '267:25722-25729.': [1800], 'Scholar10': [1802], 'Elizondo': [1805, 1875], 'E,': [1806, 1876, 2383], 'Ge': [1807, 1877], 'Boulanger': [1809, 1879], 'CM,': [1810, 1880], 'Vanhoutte': [1811, 1881], 'PM.': [1812, 1882], 'Growth': [1813], 'interleukin-1': [1817], 'β-induced': [1818], 'GTP:': [1823], 'Commun.1993;': [1834, 1869], '196:1261-1266.': [1835], 'Scholar11': [1837], 'Edgall': [1844], 'C-JS,': [1845], 'Modulation': [1848, 2994], 'human': [1850], 'activating': [1856], 'deactivating': [1858], 'cytokines:': [1859], 'new': [1860], 'perspectives': [1861], 'endothelial-derived': [1863], '196:1343-1348.': [1870], 'Scholar12': [1872], 'Simultaneous': [1883], 'C': [1891, 2250, 2319, 2387, 2829, 3022], 'induces': [1892], 'Pharmacol.1994;': [1903], '46:274-282.': [1904], 'Scholar13': [1906], 'Shen': [1907], 'R-S,': [1908], 'Zhang': [1909, 2454], 'Y,': [1910, 2028, 2619, 2663, 2730, 2732, 3079, 3081], 'Regino': [1911], 'Perez-Polo': [1912], 'J.': [1913, 2060], 'Regulation': [1914, 1939], 'dihydropterine': [1920], 'rat': [1923, 2001, 2263, 2677], 'pheochromocytoma': [1924], 'PC12': [1925], 'Enzym': [1928], 'Inhib.1989;': [1929], '3:119-126.': [1930], 'Scholar14': [1932], 'Zhu': [1933], 'Hirayama': [1935], 'K,': [1936, 2233, 2665, 2728, 2736, 2861, 3045, 3075], 'Kapatos': [1937], 'G.': [1938], 'dopamine': [1945], 'neurons': [1946], 'depolarization': [1948], 'cAMP.': [1950], 'Chem.1994;': [1953], '269:11825-11829.': [1954], 'Scholar15': [1956], 'Curran': [1957], 'RD,': [1958], 'Billiar': [1959], 'TR,': [1960], 'Ochoa': [1963], 'JB,': [1964], 'Harbrecht': [1965], 'BG,': [1966], 'Flint': [1967], 'SG,': [1968], 'Simmons': [1969], 'RL.': [1970], 'Multiple': [1971], 'hepatocyte': [1977], 'total': [1983], 'Ann': [1986], 'Surg.1990;': [1987], '212:462-471.': [1988], 'Scholar16': [1990], 'Giovanelli': [1991], 'J,': [1992, 2032, 2542, 2690, 2692], 'Campos': [1993], 'KL,': [1994], 'Kaufman': [1995], 'Tetrahydrobiopterin,': [1997], 'cerebellar': [2002], 'synthase,': [2005], 'does': [2006], 'function': [2008, 2566, 2642, 2673, 2793], 'reactant': [2011], 'oxygenation': [2014], 'arginine.': [2016], 'Proc': [2017], 'Natl': [2018], 'Acad': [2019], 'Sci': [2020], 'U': [2021, 2694], 'S': [2022, 2121, 2670, 3083, 3151], 'A.1991;': [2023], '88:7091-7095.': [2024], 'Scholar17': [2026], 'Vodovotz': [2027], 'Bogdan': [2029], 'C,': [2030, 2615, 3146], 'Paik': [2031], 'Xie': [2033], 'Q-W,': [2034], 'Nathan': [2035], 'C.': [2036], 'Mechanism': [2037], 'β.': [2048], 'Exp': [2050], 'Med.1993;': [2051], '178:605-613.': [2052], 'Scholar18': [2054], 'Stamler': [2055], 'JS,': [2056], 'Singel': [2057], 'Loscalzo': [2059], 'Biochemistry': [2061, 2415], 'redox-activated': [2067], 'forms.': [2068], '258:1898-1902.': [2070], 'Scholar': [2072], 'Previous': [2073], 'Back': [2074], 'top': [2076], 'Next': [2077], 'FiguresReferencesRelatedDetailsCited': [2078], 'By': [2079], 'Buglak': [2080, 2186, 2280], 'A,': [2081, 2239, 2243, 2281, 2621, 2871, 2906, 2912, 2953, 2959], 'Telegina': [2082, 2189, 2282], 'Vechtomova': [2084, 2286], 'Y': [2085, 2287, 2875, 3052], 'Kritsky': [2087, 2289], 'M': [2088, 2290, 2552, 3049, 3086], '(2021)': [2089], 'Autoxidation': [2090], 'photooxidation': [2092], 'tetrahydrobiopterin:': [2094], 'theoretical': [2096, 2193], 'study,': [2097], 'Radical': [2099], 'Research,': [2100, 2444], '10.1080/10715762.2020.1860213,': [2101], '55:5,': [2102], '(499-509),': [2103], 'Online': [2104, 2182, 2212, 2276, 2307, 2369, 2421, 2448, 2493, 2537, 2576, 2610, 2658, 2685, 2723, 2770, 2820, 2824, 2856, 2895, 2942, 2982, 3017, 3068, 3101, 3137, 3173], 'publication': [2105, 2183, 2213, 2277, 2308, 2370, 2422, 2449, 2494, 2538, 2577, 2611, 2659, 2686, 2724, 2771, 2821, 2825, 2857, 2896, 2943, 2983, 3018, 3069, 3102, 3138, 3174], 'date:': [2106, 2184, 2214, 2278, 2309, 2371, 2423, 2450, 2495, 2539, 2578, 2612, 2660, 2687, 2725, 2772, 2822, 2826, 2858, 2897, 2944, 2984, 3019, 3070, 3103, 3139, 3175], '4-May-2021.': [2107], 'Tavasoli': [2108], 'Liu': [2110, 2149], 'Machuca': [2112], 'Bonato': [2114], 'R,': [2115, 2235, 2374, 2617, 2900, 2904, 2910, 2951, 2957, 3106], 'Grant': [2116], 'D,': [2117, 2734, 3144], 'Cypel': [2118], 'Keshavjee': [2120], 'Grasemann': [2123], 'H': [2124, 2316, 2338, 2878], '(2020)': [2125, 2191], 'Increased': [2126, 2880], 'Arginase': [2127], 'Expression': [2128, 3158], 'Decreased': [2130], 'Pig': [2134], 'Donor': [2135], 'Lungs': [2136], 'Normothermic': [2138], 'Ex': [2139], 'Vivo': [2140], 'Lung': [2141], 'Perfusion,': [2142], 'Biomolecules,': [2143], '10.3390/biom10020300,': [2144], '10:2,': [2145], '(300)': [2146], 'Sharma': [2147, 2333], 'X,': [2150, 2546], 'Llewellyn': [2151, 2335], 'Katsurada': [2153], 'K': [2154, 2157, 2341, 2667], 'Patel': [2156, 2340], '(2019)': [2158], 'Exercise': [2159, 2557], 'training': [2160, 2558], 'augments': [2161], 'neuronal': [2162], 'dimerization': [2166], 'paraventricular': [2169], 'nucleus': [2170], 'rats': [2172, 2353], 'chronic': [2174], 'heart': [2175], 'failure,': [2176], 'Oxide,': [2178], '10.1016/j.niox.2019.03.005,': [2179], '87,': [2180], '(73-82),': [2181], '1-Jun-2019.': [2185], 'T': [2190, 2743, 3025], 'study': [2194], '5,6,7,8-tetrahydro-6-hydroxymethylpterin:': [2196], 'intrinsic': [2199], 'photoreceptor': [2200], 'properties': [2201], '6-substituted': [2203], 'tetrahydropterins,': [2204], 'Photochemical': [2205], '&': [2206, 2271], 'Photobiological': [2207], 'Sciences,': [2208, 2654], '10.1039/c8pp00322j,': [2209], '18:2,': [2210], '(516-523),': [2211], '1-Feb-2019.': [2215], 'Villamena': [2216], 'F': [2217], '(2017)': [2218], 'Reactive': [2219, 2224], 'Species': [2220, 2225], 'Biological': [2222, 2605], 'Systems': [2223, 2323], 'Detection': [2226], 'Biology,': [2228], '10.1016/B978-0-12-420017-3.00002-5,': [2229], '(65-86),': [2230], '.': [2231, 2332, 3039], 'Kupai': [2232], 'Szabó': [2234], 'Veszelka': [2236], 'Awar': [2238], 'Török': [2240], 'S,': [2241, 2314, 2544, 2548, 2581, 2775, 2902, 2947, 3047], 'Csonka': [2242], 'Baráth': [2244], 'Z,': [2245], 'Pósa': [2246], 'Varga': [2249], '(2015)': [2251], 'Consequences': [2252], 'exercising': [2254], 'ischemia–reperfusion': [2256], 'injury': [2257, 2928, 2971], 'type': [2259], '2': [2260], 'diabetic': [2261, 2568], 'Goto-Kakizaki': [2262, 2569], 'hearts:': [2264], 'HO/NOS': [2268], 'system,': [2269], 'Diabetology': [2270], 'Metabolic': [2272], 'Syndrome,': [2273], '10.1186/s13098-015-0080-x,': [2274], '7:1,': [2275, 2575], '1-Dec-2015.': [2279], 'Lyudnikova': [2284], '(2014)': [2291, 2320], 'Photooxidation': [2292], 'UV': [2296], 'Irradiation:': [2297], 'Possible': [2298], 'Pathways': [2299], 'Mechanisms,': [2301], 'Photochemistry': [2302], 'Photobiology,': [2304], '10.1111/php.12285,': [2305], '(n/a-n/a),': [2306], '1-May-2014.': [2310], 'Arunachalam': [2311], 'Samuel': [2313], 'Ding': [2315, 2456], 'Triggle': [2318], 'Peroxynitrite': [2321], 'Radicals': [2327], 'Antioxidants,': [2329], '10.1007/978-3-642-30018-9_5,': [2330], '(207-242),': [2331], 'Zheng': [2337, 2428], '(2013)': [2342, 2430], 'Angiotensin': [2343], 'II-mediated': [2344], 'posttranslational': [2345], 'modification': [2346], 'nNOS': [2348], 'PVN': [2351], 'CHF:': [2355], 'PIN,': [2358], 'Journal': [2360, 2480, 2714, 2763, 2813, 2847, 2933, 3062], 'Physiology-Heart': [2362, 2716, 2849], 'Circulatory': [2364, 2718, 2851], 'Physiology,': [2365, 2533, 2719, 2852], '10.1152/ajpheart.00170.2013,': [2366], '305:6,': [2367], '(H843-H855),': [2368], 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'H,': [2457], 'Tu': [2458], 'W': [2459, 2586, 2914, 2961], 'Yan': [2461], '(2010)': [2463], 'gene': [2467, 2594], '3′-UTR': [2468], 'C+243T': [2469], 'variant': [2470], 'predicts': [2471], 'worsening': [2472], 'outcome': [2473], 'patients': [2475], 'first-onset': [2477], 'ischemic': [2478], 'stroke,': [2479], 'Huazhong': [2482], 'University': [2483], 'Science': [2485], 'Technology': [2487], '[Medical': [2488], 'Sciences],': [2489], '10.1007/s11596-010-0642-y,': [2490], '30:6,': [2491], '(694-698),': [2492], '1-Dec-2010.': [2496], 'Yang': [2497], 'X': [2498], 'Chen': [2500], '(2009)': [2502], 'HIGH-CHOLESTEROL': [2503], 'DIET': [2504], 'AUGMENTS': [2505], 'ENDOTHELIAL': [2506], 'DYSFUNCTION': [2507], 'VIA': [2508], 'ELEVATED': [2509], 'OXIDATIVE': [2510], 'STRESS': [2511], 'AND': [2512], 'REDUCED': [2513], 'TETRAHYDROBIOPTERIN': [2514], 'IN': [2515], 'INS2': [2516], 'AKITA': [2517], 'MICE,': [2518], 'AN': [2519], 'AUTOSOMAL': [2520], 'DOMINANT': [2521], 'MUTANT': [2522], 'TYPE': [2523], 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'Xia': [2618], 'Cardounel': [2620], 'G': [2625, 2785, 2917, 2992, 3113], '(2007)': [2629], 'Myocardial': [2630], '(BH': [2635], ')': [2637], 'impaired': [2640], 'ameliorated': [2643], 'BH': [2645], 'Proceedings': [2648], 'National': [2651], 'Academy': [2652], '10.1073/pnas.0702986104,': [2655], '104:38,': [2656], '(15081-15086),': [2657], '18-Sep-2007.': [2661], 'Hara': [2662], 'Teramoto': [2664], 'Ishidate': [2666], 'Arii': [2669], '(2006)': [2671, 2698], 'Cytoprotective': [2672], 'liver': [2678], 'ischemia/reperfusion': [2679, 2970], 'injury,': [2680], 'Surgery,': [2681, 2816, 2938], '10.1016/j.surg.2005.08.019,': [2682], '139:3,': [2683], '(377-384),': [2684], '1-Mar-2006.': [2688], 'Symons': [2689], 'Rutledge': [2691], 'Simonsen': [2693], 'Pattathu': [2696], 'R': [2697, 2788, 2964], 'hyperhomocysteinemia': [2703], 'more': [2705], 'severe': [2706], 'low': [2711], 'folate,': [2712], '10.1152/ajpheart.00765.2005,': [2720], '290:1,': [2721], '(H181-H191),': [2722], '1-Jan-2006.': [2726], 'Shinozaki': [2727], 'Nishio': [2729], 'Yoshida': [2731], 'Koya': [2733], 'Ayajiki': [2735], 'Masada': [2737], 'Kashiwagi': [2739], 'Okamura': [2742], '(2005)': [2744], 'Supplement': [2745], 'Gene': [2750], 'Transfer': [2751], 'Cyclohydrolase': [2754], 'cDNA': [2756], 'Improves': [2757], 'Dysfunction': [2759], 'Insulin-Resistant': [2761], 'Rats,': [2762], 'Pharmacology,': [2766], '10.1097/01.fjc.0000177981.91434.ba,': [2767], '46:4,': [2768], '(505-512),': [2769], '1-Oct-2005.': [2773], 'Hillinger': [2774, 2901, 2946], 'Sandera': [2776], 'Carboni': [2778], 'Stammberger': [2780, 2907, 2954], 'U,': [2781, 2908, 2955], 'Zalunardo': [2782], 'Schmid': [2787, 2899, 2963], '(2001)': [2789, 2830, 2879], 'Survival': [2790], 'graft': [2792], 'animal': [2797], 'lung': [2798, 2930, 2968], 'transplant': [2799], 'model': [2800], '30': [2802], 'h': [2803], 'preservation': [2804], 'substitution': [2806], 'pathway,': [2811], 'European': [2812], 'Cardio-Thoracic': [2815], 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[2931], 'Thoracic': [2935], '10.1016/S0022-5223(99)70019-X,': [2939], '118:4,': [2940], '(726-732),': [2941], '1-Oct-1999.': [2945], 'Reduction': [2966], 'coenzyme': [2974], 'NOS,': [2976], 'Transplantation': [2977], 'Proceedings,': [2978], '10.1016/S0041-1345(98)01494-8,': [2979], '31:1-2,': [2980], '(183-184),': [2981], '1-Feb-1999.': [2985], 'Linscheid': [2986], '(1998)': [2993, 3026], 'Inducible': [2996], 'Synthase': [2999, 3157], 'Stability': [3001], 'Smooth': [3006, 3162], 'Muscle': [3007, 3163], 'Cells,': [3008, 3164], 'Biochemical': [3009, 3129, 3165], 'Biophysical': [3011, 3131, 3167], 'Research': [3012, 3132, 3168], 'Communications,': [3013, 3133, 3169], '10.1006/bbrc.1998.8072,': [3014], '243:1,': [3015], '(137-141),': [3016], '1-Feb-1998.': [3020], 'Tock': [3021, 3145], 'Tissue': [3027, 3035], 'Engineering': [3028], 'Applied': [3029], 'Frontiers': [3033], 'Engineering,': [3036], '10.1016/B978-008042689-1/50033-9,': [3037], '(580-597),': [3038], 'Iizuka': [3040, 3072], 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