Regulation of Actin Polymerization by Arp2/3 Complex and WASp/Scar Proteins

Name: Work Video:
Duration: 3 min 30 s
Henry N. Higgs; Thomas D. Pollard
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'L.P.': [48], 'Cell.': [49, 854, 1093, 1753, 2049, 2518, 2561, 2647, 2860, 2936, 3081, 3154, 3953, 4267, 4490, 4848, 5335, 5538], '1996;': [50, 138, 284, 795, 815, 834, 1237, 1754, 1788, 2519, 2583, 2686, 2723, 2752, 2782, 3126, 4550, 5044, 5168], '84:': [51, 1755, 2520], '371-379Abstract': [52], 'Full': [53, 55, 141, 876, 878, 1038, 1040, 1097, 1099, 1118, 1120, 1141, 1143, 1371, 1373, 1432, 1434, 1757, 1759, 1982, 1984, 2053, 2055, 2074, 2076, 2097, 2099, 2136, 2138, 2179, 2181, 2413, 2415, 2522, 2524, 2565, 2567, 2612, 2614, 2651, 2653, 2726, 2728, 2755, 2757, 2969, 2971, 3158, 3160, 3190, 3192, 3879, 3881, 3957, 3959, 4010, 4012, 4132, 4134, 4162, 4164, 4389, 4391, 4494, 4496, 4553, 4555, 4852, 4854, 5027, 5029, 5139, 5141, 5315, 5317, 5339, 5542, 5544], 'Text': [54, 56, 142, 877, 879, 1039, 1041, 1098, 1100, 1119, 1121, 1142, 1144, 1372, 1374, 1433, 1435, 1758, 1760, 1983, 1985, 2054, 2056, 2075, 2077, 2098, 2100, 2137, 2139, 2180, 2182, 2414, 2416, 2523, 2525, 2566, 2568, 2613, 2615, 2652, 2654, 2727, 2729, 2756, 2758, 2970, 2972, 3159, 3161, 3191, 3193, 3880, 3882, 3958, 3960, 4011, 4013, 4133, 4135, 4163, 4165, 4390, 4392, 4495, 4497, 4554, 4556, 4853, 4855, 5028, 5030, 5140, 5142, 5316, 5318, 5340, 5543, 5545], 'PDF': [57, 143, 880, 1042, 1101, 1122, 1145, 1375, 1436, 1761, 1986, 2057, 2078, 2101, 2140, 2183, 2417, 2526, 2569, 2616, 2655, 2730, 2759, 2973, 3162, 3194, 3883, 3961, 4014, 4136, 4166, 4393, 4498, 4557, 4856, 5031, 5143, 5319, 5341, 5546], 'PubMed': [58, 112, 144, 211, 252, 287, 363, 400, 446, 508, 537, 589, 617, 640, 663, 678, 709, 724, 759, 780, 798, 818, 837, 858, 881, 902, 946, 998, 1043, 1074, 1102, 1123, 1146, 1240, 1269, 1290, 1311, 1334, 1355, 1376, 1437, 1452, 1465, 1502, 1543, 1594, 1633, 1762, 1791, 1819, 1857, 1906, 1962, 1987, 2030, 2058, 2079, 2102, 2141, 2184, 2289, 2317, 2418, 2527, 2543, 2570, 2586, 2617, 2640, 2656, 2673, 2689, 2731, 2760, 2803, 2840, 2864, 2901, 2924, 2941, 2974, 3129, 3163, 3195, 3302, 3368, 3519, 3827, 3884, 3920, 3962, 4015, 4118, 4137, 4167, 4208, 4252, 4271, 4347, 4394, 4499, 4538, 4558, 4754, 4775, 4857, 4889, 4917, 4940, 4955, 4976, 4993, 5032, 5047, 5063, 5144, 5171, 5188, 5204, 5220, 5257, 5320, 5342, 5408, 5424, 5475, 5547], 'Scopus': [59, 113, 145, 288, 401, 447, 509, 538, 590, 618, 641, 664, 679, 710, 725, 760, 781, 799, 819, 838, 859, 882, 903, 947, 999, 1044, 1075, 1103, 1124, 1147, 1241, 1270, 1291, 1312, 1335, 1356, 1377, 1438, 1453, 1466, 1503, 1544, 1595, 1634, 1763, 1792, 1820, 1858, 1907, 1963, 2031, 2059, 2080, 2103, 2142, 2185, 2290, 2318, 2419, 2528, 2544, 2571, 2587, 2618, 2641, 2657, 2674, 2690, 2732, 2761, 2804, 2865, 2942, 2975, 3130, 3164, 3196, 3303, 3520, 3828, 3885, 3921, 3963, 4016, 4119, 4138, 4168, 4209, 4253, 4272, 4348, 4395, 4500, 4539, 4559, 4755, 4776, 4858, 4890, 4918, 4941, 4956, 4977, 4994, 5033, 5048, 5064, 5145, 5172, 5189, 5205, 5221, 5258, 5321, 5343, 5409, 5425, 5476, 5548], '(1310)': [60], 'Google': [61, 115, 147, 212, 253, 290, 364, 403, 449, 511, 540, 592, 620, 643, 666, 681, 712, 727, 762, 783, 801, 821, 840, 861, 884, 905, 949, 1001, 1046, 1077, 1105, 1126, 1149, 1227, 1243, 1272, 1293, 1314, 1337, 1358, 1379, 1440, 1455, 1468, 1505, 1546, 1597, 1636, 1698, 1765, 1794, 1822, 1860, 1909, 1965, 1988, 2033, 2061, 2082, 2105, 2144, 2187, 2292, 2320, 2421, 2530, 2546, 2573, 2589, 2620, 2643, 2659, 2676, 2692, 2707, 2734, 2763, 2785, 2806, 2841, 2867, 2902, 2925, 2944, 2958, 2977, 3085, 3132, 3166, 3198, 3305, 3369, 3522, 3830, 3887, 3923, 3965, 4018, 4121, 4140, 4170, 4211, 4255, 4274, 4350, 4397, 4502, 4541, 4561, 4757, 4778, 4860, 4892, 4920, 4943, 4958, 4979, 4996, 5035, 5050, 5066, 5147, 5174, 5191, 5207, 5223, 5260, 5323, 5345, 5411, 5427, 5478, 5550], 'Scholar).': [62, 116, 148, 213, 254, 291, 450, 512, 728, 906, 950, 1002, 1150, 1244, 1469, 1506, 1547, 1598, 1637, 1699, 1766, 1823, 1861, 1910, 1989, 2106, 2145, 2188, 2293, 2321, 2422, 3086, 3306, 3370, 3523, 3831, 3924, 3966, 4019, 4171, 4212, 4275, 4351, 4503, 4562, 4779, 4861, 4997, 5148, 5224, 5261, 5428, 5479, 5551], 'In': [63, 255, 1933, 2333, 5092, 5278, 5429], 'the': [64, 69, 85, 93, 219, 227, 234, 260, 485, 489, 543, 571, 685, 688, 911, 920, 962, 969, 1023, 1383, 1389, 1528, 1559, 1569, 1579, 1603, 1606, 1834, 1917, 2216, 2228, 2248, 2371, 2377, 2387, 2439, 2467, 3050, 3063, 3066, 3089, 3095, 3173, 3208, 3216, 3249, 3267, 3272, 3321, 3342, 3352, 3375, 3378, 3384, 3390, 3398, 3419, 3436, 3451, 3468, 3470, 3480, 3499, 3534, 3550, 3557, 3560, 3574, 3607, 3618, 3626, 3632, 3648, 3658, 3670, 3689, 3707, 3717, 3763, 3843, 3852, 3867, 3977, 3980, 4023, 4052, 4058, 4091, 4175, 4178, 4196, 4220, 4229, 4294, 4319, 4324, 4328, 4442, 4515, 4603, 4657, 4676, 4698, 4794, 4798, 4811, 4832, 4868, 5004, 5071, 5080, 5113, 5263, 5348, 5390, 5436, 5441, 5493, 5498, 5509, 5515, 5583, 5614, 5636], 'lamellipodia': [65], 'that': [66, 416, 424, 913, 1006, 1214, 1382, 1394, 1405, 1561, 1567, 1602, 1713, 2121, 2203, 2298, 2491, 3062, 3201, 3657, 3706, 4074, 4400, 4814, 5151, 5232, 5387, 5523, 5579], 'push': [67], 'forward': [68], 'leading': [70, 490, 572, 4179, 4795], 'edge': [71, 491, 573, 4180], 'motile': [73, 575], 'cells,': [74, 1673], 'polymerizing': [75], 'filaments': [76, 172, 274, 305, 312, 338, 423, 481, 553, 1574, 1733, 3275, 3313, 3355, 3433, 3543, 3639, 3720, 3732, 3767, 3775, 4176, 4227, 4473, 5159, 5288, 5588], 'form': [77, 1563, 2255, 3387, 3426, 4232], 'a': [78, 122, 160, 175, 186, 468, 558, 915, 1156, 1172, 1204, 1564, 1703, 1841, 1893, 1936, 2111, 2117, 2160, 2211, 2245, 2258, 2260, 2382, 2460, 3003, 3047, 3071, 3408, 3427, 3458, 3531, 3578, 3680, 3725, 4035, 4078, 4425, 4634, 4667, 4703, 4804, 5102, 5301], 'meshwork': [79, 118], 'consisting': [80, 2360], '"Y': [82], 'branches"': [83], 'with': [84, 1155, 1401, 1609, 1683, 1802, 2110, 2167, 2355, 2493, 3088, 3207, 3215, 3585, 3641, 3669, 3694, 3709, 3724, 3781, 3866, 4191, 4298, 4721, 4791, 5101, 5353, 5508], 'pointed': [86, 237, 1570, 1607, 4221, 5114], 'end': [87, 231, 238, 262, 407, 1571, 1608, 3453, 3455, 4222, 5115, 5121], 'one': [89, 1474, 3323, 3838], 'filament': [90, 97, 222, 982, 3462, 3473, 3621, 3675, 4431, 4691, 4871, 5073, 5447, 5566, 5623], 'attached': [91], 'to': [92, 164, 271, 313, 928, 958, 974, 1013, 1163, 1170, 1558, 2215, 2234, 2424, 2464, 3070, 3354, 3416, 3425, 3454, 3598, 3716, 3734, 3795, 3992, 4050, 4231, 4429, 4470, 4614, 4630, 4717, 4822, 5002, 5295, 5438, 5526, 5531, 5617, 5633, 5644, 5647], 'side': [94, 3671, 4224], 'another': [96], '(2Svitkina': [98], 'T.M.': [99, 669, 715, 4199, 4946], 'Verkhovsky': [100], 'A.B.': [101], 'McQuade': [102], 'K.M.': [103], 'Borisy': [104, 670, 716, 4200, 4947], 'G.G.': [105, 671, 717, 4201, 4948], 'J.': [106, 137, 281, 357, 394, 583, 613, 634, 657, 672, 703, 718, 794, 814, 831, 935, 937, 994, 1236, 1263, 1300, 1305, 1328, 1344, 1349, 1446, 1459, 1537, 1588, 1787, 1851, 1902, 1956, 2582, 2601, 2606, 2667, 2685, 2702, 2780, 2831, 2847, 2892, 2953, 2963, 3125, 4202, 4262, 4547, 4750, 4769, 4883, 4913, 4934, 4949, 4970, 4987, 5043, 5059, 5167, 5200, 5309, 5404, 5420], 'Cell': [107, 282, 358, 395, 584, 635, 658, 673, 704, 719, 832, 1264, 1306, 1329, 1350, 1447, 1460, 1538, 1589, 1852, 1957, 2668, 4203, 4770, 4884, 4935, 4950, 4971, 4988], 'Biol.': [108, 283, 396, 585, 636, 659, 674, 705, 720, 833, 853, 872, 1034, 1114, 1137, 1265, 1307, 1330, 1351, 1367, 1428, 1448, 1461, 1498, 1539, 1590, 1853, 1958, 1978, 2070, 2093, 2132, 2175, 2285, 2409, 2607, 2669, 2722, 2751, 2859, 2937, 2964, 3186, 3875, 4006, 4128, 4158, 4204, 4266, 4385, 4548, 4771, 4885, 4936, 4951, 4972, 4989, 5023, 5135, 5310], '1997;': [109, 614, 855, 873, 1308, 1352, 1429, 1449, 1462, 1959, 2286, 2637, 2670, 2861, 4159, 4751, 4772, 4914, 4973, 4990], '139:': [110, 2671], '397-415Crossref': [111], '(564)': [114], 'This': [117, 1003, 1016, 2107, 3654, 3683], 'presumably': [119], 'may': [120, 466, 3836, 4029, 4287, 4321, 4688, 4827, 5596], 'provide': [121, 2459], 'rigid': [123], 'body': [124], 'against': [125], 'which': [126, 2376, 3106, 3539, 4417, 5068, 5083, 5639], 'can': [128, 3107, 3476, 4526], 'drive': [129], 'membrane': [130, 1886, 3232, 4833], 'protrusion': [131], '(3Mogilner': [132], 'A.': [133, 391, 442, 504, 533, 603, 652, 698, 776, 788, 806, 826, 898, 1070, 1133, 1286, 1629, 1752, 2026, 2089, 2517, 2599, 2605, 2636, 2905, 2930, 3298, 3515, 3823, 3916, 4114, 4248, 4343, 4533, 4740, 4766, 4903, 4929, 4967, 5471], 'Oster': [134], 'G.': [135, 767, 847, 2662], 'Biophys.': [136, 2311, 2537, 5214], '71:': [139], '3030-3045Abstract': [140], '(714)': [146], 'A': [149, 1872, 2350, 3789, 3859, 3926, 3981, 4352], 'major': [150, 4079], 'unanswered': [151], 'question': [152, 5553], 'how': [154, 3327, 4784], 'cells': [155, 256, 576, 1219, 1254, 1736, 1777, 1806, 1868, 3230, 3247], 'integrate': [156], 'signals': [157, 4401, 4420, 4436], 'coming': [158], 'through': [159, 4361, 4421], 'variety': [161, 1157, 4353], 'pathways': [163, 4409], 'control': [165], 'when': [166, 1800], 'where': [168, 1828, 3533], 'actin': [169, 180, 197, 295, 420, 456, 472, 480, 956, 981, 1179, 1216, 1248, 1416, 1573, 1662, 1724, 1732, 1948, 2124, 2217, 2304, 3261, 3312, 3328, 3334, 3345, 3423, 3537, 3547, 3638, 3730, 3766, 3784, 4061, 4093, 4144, 4226, 4358, 4430, 4472, 4690, 4870, 5017, 5088, 5100, 5125, 5158, 5235, 5275, 5298, 5530, 5565, 5587, 5622, 5640], 'polymerizes.': [170], 'The': [171, 214, 907, 1181, 1470, 1513, 1519, 1638, 1664, 1700, 1767, 1990, 2152, 2322, 2345, 3238, 3255, 3430, 3524, 3553, 3580, 3752, 3786, 3832, 3858, 3925, 4213, 4452, 4649, 5010, 5573, 5605], 'grow': [173, 425, 3541], 'from': [174, 306, 484, 919, 1189, 2329, 3479, 3573, 4402, 4803], 'huge': [176], 'pool': [177], 'unpolymerized': [179], 'maintained': [181], 'by': [182, 379, 461, 955, 984, 1838, 2001, 3137, 3263, 3314, 3330, 3333, 3439, 3443, 3530, 3544, 3559, 3566, 3625, 3721, 3798, 3995, 4064, 4283, 4641, 4694, 5361, 5589, 5601, 5638], 'monomer-binding': [183, 215, 462, 2218], 'proteins': [184, 258, 1019, 1152, 1660, 1997, 2458, 2477, 3056, 3227, 3308, 3597, 4066, 4277, 4579, 4599, 4682, 4786, 4819, 5358, 5581, 5595], 'at': [185, 226, 426, 488, 570, 684, 3377, 3549, 4177, 4195, 4793, 5112, 5370], 'concentration': [187, 3399, 3471, 3562], 'approximately': [188, 1524], '1000-fold': [189], 'higher': [190], 'than': [191, 1778, 2268, 2481, 4038, 4874, 5489, 5502], 'spontaneous': [194, 3381, 3722], '4Pollard': [201, 242], 'T.D.': [202, 243, 435, 497, 526, 582, 1063, 1365, 1494, 1536, 1587, 1622, 2019, 2280, 2962, 3291, 3359, 3508, 3816, 3909, 4126, 4241, 4264, 4882, 4986, 5308, 5464], 'Cooper': [203, 244, 279, 632, 3360], 'J.A.': [204, 245, 280, 433, 495, 524, 633, 1620, 3361, 3506, 4239], 'Annu.': [205, 246, 3362], 'Rev.': [206, 247, 3363], 'Biochem.': [207, 248, 612, 2310, 2536, 3364, 4749, 4912, 5213], '1986;': [208, 249, 397, 3365], '55:': [209, 250, 3366], '987-1035Crossref': [210, 251, 3367], 'protein': [216, 918, 972, 1196, 1482, 2219, 2374, 2436, 4365, 4459, 4707], 'profilin': [217, 5388, 5431, 5506, 5524, 5559, 5570], 'biases': [218], 'direction': [220, 1581], 'elongation,': [223], 'allowing': [224], 'fast': [228], 'growing': [229, 236], 'barbed': [230, 261, 316, 322, 406, 428, 1580, 3474, 3551, 5120, 5240], 'but': [232, 336, 977, 3168, 3389, 3441, 3498, 3603, 3845, 3889, 4081, 4286, 4376, 4618, 5116, 5347, 5497], 'not': [233, 1891, 3605, 3847, 3891, 4083, 4279, 4513, 4593, 4782, 5090, 5118, 5513, 5612], 'slow': [235, 5562], 'capping': [257], 'block': [259], 'most': [264, 4089, 4173, 4591], 'filaments,': [265, 5236], 'so': [266, 3771], 'some': [267, 2397, 5384], 'mechanism': [268, 3322], 'start': [272], 'new': [273, 337, 552, 3004, 3681, 5239, 5446, 5586, 5609], '(5Schafer': [275], 'D.A.': [276, 623, 939, 1055, 1972, 2011, 3283, 3808, 3901, 5456], 'Jennings': [277], 'P.B.': [278], '135:': [285], '169-179Crossref': [286], '(337)': [289], 'Cells': [292], 'might': [293, 1009, 1715, 1881, 2395, 4589, 4620, 5069], 'trigger': [294, 5444], 'three': [298, 1650], 'ways:': [299], '1)': [300], 'de': [301, 376], 'novo': [302, 377], 'nucleation': [303, 378, 452, 545, 1615, 2000, 3136, 3262, 3310, 3372, 3440, 3660, 3678, 3797, 3893, 3994, 4692, 4800, 5075, 5360, 5532], 'monomeric': [307, 5016, 5099], 'actin;': [308], '2)': [309], 'severing': [310, 5266, 5627], 'existing': [311, 321, 3674], 'create': [314], 'uncapped': [315], 'ends;': [317], '3)': [319], 'uncapping': [320], 'ends.': [323, 3463], 'There': [324], 'evidence': [326, 1657, 2297, 4072, 5385], 'each': [328, 1477], 'these': [330, 515, 1659, 1719, 2190, 2240, 3226, 3244, 3401, 4026, 4233, 4419, 4435, 4529, 4596, 5608], 'mechanisms': [331, 369, 5620, 5637], 'various': [333], 'cellular': [334, 1007, 4357, 5391], 'processes,': [335], 'are': [339, 1413, 1510, 1517, 2193, 3527, 3793, 3932, 4185, 4278, 4315, 4460, 4573, 4820, 5642], 'often': [340, 4801], 'created': [341], 'during': [342, 3435, 5074, 5329], 'motility': [344], '(6Chan': [345], 'A.Y.': [346], 'Raft': [347], 'S.': [348, 441, 503, 532, 775, 897, 1069, 1285, 1628, 1744, 1898, 1934, 2025, 2509, 2635, 2710, 2739, 2769, 2811, 2817, 2821, 2835, 2845, 2872, 2878, 2882, 2896, 3297, 3514, 3822, 3915, 4113, 4247, 4342, 4764, 4965, 5055, 5196, 5400, 5414, 5470], 'Bailly': [349], 'M.': [350, 389, 646, 650, 692, 696, 808, 810, 868, 992, 1086, 1298, 1319, 1325, 1327, 1342, 1424, 1738, 2042, 2503, 2554, 2793, 2813, 2825, 2853, 2874, 2886, 2915, 3147, 3946, 4154, 4483, 4841, 4923, 4927], 'Wyckoff': [351], 'J.B.': [352], 'Segall': [353, 653, 699, 4930], 'J.E.': [354, 654, 700, 1846, 4931], 'Condeelis': [355, 655, 701, 4932], 'J.S.': [356, 656, 702, 4933], 'Sci.': [359, 439, 501, 530, 773, 895, 1067, 1283, 1626, 2023, 2633, 3295, 3512, 3820, 3913, 4111, 4245, 4340, 5468], '1998;': [360, 443, 505, 534, 637, 943, 995, 1035, 1224, 1266, 1287, 1331, 1630, 1695, 1816, 1854, 1903, 1979, 2133, 2176, 2314, 2540, 2609, 2648, 2800, 2921, 2966, 3187, 3516, 3876, 4115, 4249, 4268, 4386, 4535, 5024, 5060, 5136, 5185, 5201, 5217, 5254, 5312, 5405, 5421, 5539], '111:': [361], '199-211Crossref': [362], 'Scholar),': [365, 404, 682, 1359, 3167, 4141, 5067, 5346], 'placing': [366], 'emphasis': [367], 'on': [368, 514, 1916, 2498, 3246, 3351, 4099, 4323, 4411, 4831, 4875, 5635], '2.': [372], 'Although': [373, 4020], 'stimulation': [381, 1177], 'has': [382, 1613, 2147, 2338], 'long': [383], 'been': [384, 2488], 'an': [385, 1679, 2265, 2269, 2432, 3033, 3044, 3098, 3113, 3673, 3984, 4377], 'attractive': [386, 4378], 'model': [387, 3532, 3554, 3661], '(7Carson': [388], 'Weber': [390], 'Zigmond': [392], 'S.H.': [393, 1296, 1317, 1340], '103:': [398], '2707-2714Crossref': [399], '(61)': [402], 'no': [405], 'nucleating': [408], 'factors': [409, 1008, 1028], 'were': [410, 1020], 'known': [411, 1162, 1939], 'until': [412], 'it': [413, 1889, 2337, 3772, 5233], 'was': [414, 910, 1825], 'discovered': [415, 1826], 'Arp2/3': [417, 464, 476, 548, 566, 738, 926, 1011, 1395, 1411, 1471, 2002, 2168, 2485, 3236, 3264, 3315, 3493, 3589, 3599, 3642, 3667, 3710, 3736, 3759, 3799, 3936, 3997, 4032, 4075, 4100, 4192, 4216, 4284, 4422, 4445, 4468, 4616, 4695, 4712, 4788, 4829, 4863, 5007, 5362, 5442, 5518, 5590], 'complex': [418, 465, 477, 549, 567, 739, 927, 1012, 1396, 1412, 1472, 1520, 1604, 2003, 2169, 2486, 3218, 3316, 3494, 3535, 3575, 3600, 3643, 3668, 3711, 3737, 3760, 3800, 3937, 3998, 4033, 4076, 4101, 4193, 4217, 4230, 4285, 4423, 4446, 4469, 4713, 4789, 4830, 4864, 5008, 5363], 'promotes': [419, 3496], 'nucleation,': [421, 5434], 'creating': [422], 'their': [427], 'ends': [429, 3475, 5241], '(8Mullins': [430, 492, 521, 1617, 3503, 4236], 'R.D.': [431, 493, 522, 1363, 1492, 1618, 3504, 4124, 4237, 4258, 4982], 'Heuser': [432, 494, 523, 1619, 3505, 4238], 'Pollard': [434, 496, 525, 581, 1062, 1364, 1493, 1535, 1586, 1621, 2018, 2279, 2961, 3290, 3507, 3815, 3908, 4125, 4240, 4263, 4881, 4985, 5307, 5463], 'Proc.': [436, 498, 527, 770, 892, 1064, 1280, 1623, 2020, 2630, 3292, 3509, 3817, 3910, 4108, 4242, 4337, 5465], 'Natl.': [437, 499, 528, 771, 893, 1065, 1281, 1624, 2021, 2631, 3293, 3510, 3818, 3911, 4109, 4243, 4338, 5466], 'Acad.': [438, 500, 529, 772, 894, 1066, 1282, 1625, 2022, 2632, 3294, 3511, 3819, 3912, 4110, 4244, 4339, 5467], 'U.': [440, 502, 531, 774, 896, 1068, 1284, 1627, 1750, 2024, 2515, 2634, 3296, 3513, 3821, 3914, 4112, 4246, 4341, 5469], '95:': [444, 506, 535, 1288, 1631, 2649, 3517, 4116, 4250, 5540], '6181-6186Crossref': [445, 507, 536, 1632, 3518, 4251], '(1046)': [448, 510, 539, 1635, 3521, 4254], 'Because': [451, 4797], 'rate-limiting': [454], 'strongly': [459, 1480, 2161], 'suppressed': [460], 'proteins,': [463, 4416, 4685], 'be': [467, 1882, 2244, 3477, 4718, 5268, 5599], 'key': [469], 'mediator': [470], 'cells.': [475, 966, 4451], 'also': [478, 1153, 3031, 3442, 3616, 3933, 4715, 5631], 'cross-links': [479, 555], 'end-to-side,': [482], 'indistinguishable': [483], 'Y': [486, 689], 'branches': [487, 690, 4197], 'Based': [513], 'biochemical': [516, 3220], 'activities,': [517], 'Mullins': [518, 1050, 2006, 3278, 3803, 3896, 5451], 'et': [519], 'al.': [520], 'Scholar)': [541, 1380, 1795, 3133, 3199, 3888, 4398, 5324], 'proposed': [542, 5227], 'dendritic': [544, 3659], 'model,': [546], 'whereby': [547], 'both': [550, 3762, 4219, 4291], 'creates': [551], 'them': [556], 'into': [557, 3228, 3446, 3542, 4187], 'branching': [559, 4189, 4282], 'meshwork.': [560], 'Cellular': [561], 'observations': [562], 'support': [563], 'this': [564, 2204, 2299, 2358, 2425, 4046, 5554], 'model.': [565], 'concentrated': [569, 4866], '(9Kelleher': [577, 1531, 1582, 4877], 'J.F.': [578, 1532, 1583, 1848, 4260, 4878], 'Atkinson': [579, 1533, 1584, 4879], 'S.J.': [580, 1534, 1585, 4880], '1995;': [586, 1540, 1591, 2938, 4886], '131:': [587, 1541, 1592, 4887], '385-397Crossref': [588, 1542, 1593, 4888], '(163)': [591, 1545, 1596, 4891], 'Scholar,': [593, 621, 644, 667, 713, 763, 784, 802, 822, 841, 862, 885, 1047, 1078, 1106, 1127, 1228, 1273, 1294, 1315, 1441, 1456, 1966, 2034, 2062, 2083, 2531, 2574, 2621, 2644, 2660, 2708, 2807, 2903, 2926, 4122, 4256, 4542, 4758, 4893, 4921, 4944, 4959, 4980, 5051, 5175, 5192, 5208, 5412], '10Machesky': [594, 4894], 'L.M.': [595, 627, 1030, 1049, 2005, 2128, 2171, 3182, 3277, 3802, 3871, 3895, 4381, 4732, 4895, 5019, 5131, 5450], 'Reeves': [596, 4733, 4896], 'E.': [597, 752, 4734, 4897], 'Wientjes': [598, 4735, 4898], 'F.': [599, 648, 694, 1748, 2513, 4736, 4899, 4925], 'Mattheyse': [600, 4737, 4900], 'F.J.': [601, 4738, 4901], 'Grogan': [602, 4739, 4902], 'Totty': [604, 4741, 4904], 'N.F.': [605, 4742, 4905], 'Burlingame': [606, 4743, 4906], 'A.L.': [607, 1976, 4744, 4907], 'Hsuan': [608, 4745, 4908], 'J.J.': [609, 4746, 4909], 'Segal': [610, 4747, 4910], 'A.W.': [611, 4748, 4911], '328:': [615, 4752, 4915], '105-112Crossref': [616, 4753, 4916], '(178)': [619, 4756, 4919], '11Schafer': [622], 'Welch': [624, 1134, 2090], 'M.D.': [625, 933, 1135, 2091, 2716, 2745, 4760, 4961], 'Machesky': [626, 3178], 'Bridgman': [628], 'P.C.': [629], 'Meyer': [630], 'S.M.': [631], '143:': [638], '1919-1930Crossref': [639], '(152)': [642], '12Bailly': [645, 4922], 'Macaluso': [647, 693, 4924], 'Cammer': [649, 695, 4926], 'Chan': [651, 697, 4928], '1999;': [660, 675, 706, 721, 899, 1071, 1094, 1115, 1138, 1368, 1499, 2027, 2050, 2071, 2094, 2410, 2562, 2704, 2837, 2898, 2955, 3082, 3155, 3299, 3824, 3917, 3954, 4007, 4129, 4205, 4344, 4491, 4849, 4937, 4952, 5472], '145:': [661, 676, 707, 722, 4206, 4938, 4953], '331-345Crossref': [662, 708, 4939], '(175)': [665, 711, 4942], '13Svitkina': [668, 714, 4945], '1009-1026Crossref': [677, 723, 4207, 4954], '(914)': [680, 726, 4210, 4957], 'specifically': [683], 'junctions': [686], '(12Bailly': [691], 'It': [729, 4780, 5109], 'exists': [730], 'all': [732, 4527, 4594], 'eukaryotes': [733], 'examined,': [734], 'ablation': [736], 'subunits': [740, 1483, 1516, 3548, 4714, 5328, 5646], 'inSaccharomyces': [741], 'cerevisiae': [742], 'Schizosaccharomyces': [744], 'pombe': [745], 'lethal': [747], 'or': [748, 1879, 1942, 2364, 2469, 2473, 3778, 3839, 3854, 4290, 4447, 4643, 4824, 5123, 5289, 5378, 5533, 5628], 'severely': [749], 'debilitating': [750], '(14Schwob': [751], 'Martin': [753, 827, 2663], 'R.P.': [754, 828], 'Nature.': [755, 1815, 5184, 5253], '1992;': [756, 777], '355:': [757], '179-182Crossref': [758], '(98)': [761], '15Lees-Miller': [764], 'J.P.': [765], 'Henry': [766], 'Helfman': [768], 'D.M.': [769, 1051, 2007, 2697, 2948, 3279, 3804, 3897, 5452], '89:': [778], '80-83Crossref': [779], '(75)': [782, 4273], '16Balasubramanian': [785], 'M.K.': [786], 'Feoktistova': [787, 805], 'McCollum': [789], 'D.': [790, 804, 864, 1108, 1129, 1420, 2064, 2085, 2403, 3747, 3972, 4000, 4150, 5332], 'Gould': [791, 811], 'K.L.': [792, 812], 'EMBO': [793, 813, 993, 1235, 1786, 1901, 2581, 2684, 3124, 5042, 5058, 5166, 5199, 5403, 5419], '15:': [796, 816, 1238, 1789, 2584, 2687, 2939, 3127, 5045, 5169], '6426-6437Crossref': [797], '(76)': [800], '17McCollum': [803], 'Morphew': [807], 'Balasubramanian': [809], '6438-6446Crossref': [817], '(114)': [820], '18Moreau': [823], 'V.': [824, 843, 1746, 2511], 'Madania': [825], 'Winsor': [829, 850], 'B.': [830, 851, 1742, 2507, 2855], '134:': [835], '117-132Crossref': [836], '(111)': [839], '19Moreau': [842], 'Galan': [844], 'J.M.': [845], 'Devilliers': [846], 'Haguenauer-Tsapis': [848], 'R.': [849, 870, 891, 1080, 1112, 1277, 1426, 1445, 1458, 1955, 1970, 2036, 2068, 2407, 2548, 2789, 2849, 3141, 3940, 4004, 4105, 4156, 4336, 4477, 4835], 'Mol.': [852, 2858, 2935, 4265], '8:': [856, 1036, 1980, 2134, 2177, 2862, 3188, 3877, 4387, 5025, 5137], '1361-1375Crossref': [857], '(126)': [860], '20Winter': [863], 'Podtelejnikov': [865, 1421, 4151], 'A.V.': [866, 1422, 4152], 'Mann': [867, 1423, 4153], 'Li': [869, 890, 1111, 1425, 1444, 2067, 2406, 2856, 4003, 4155, 4335], 'Curr.': [871, 1033, 1113, 1136, 1366, 1427, 1495, 1977, 2069, 2092, 2131, 2174, 2408, 2721, 2750, 3185, 3874, 4005, 4127, 4157, 4384, 5022, 5134], '7:': [874, 1430, 4160], '519-529Abstract': [875, 1431, 4161], '(207)': [883, 1439, 4169], '21Winter': [886], 'D.C.': [887, 4332], 'Choe': [888, 4333], 'E.Y.': [889, 2851, 4334], '96:': [900, 1072, 2028, 3300, 3825, 3918, 4345, 5473], '7288-7293Crossref': [901, 4346], '(165)': [904, 4349], 'next': [908], 'breakthrough': [909], 'discovery': [912], 'ActA,': [914], 'surface': [917, 1175, 4805], 'pathogenic': [921], 'bacterium,': [922], 'Listeria': [923, 951], 'monocytogenes,': [924], 'stimulates': [925], 'nucleate': [929, 1014, 4471], 'actinin': [930], 'vitro': [931, 4475, 5430], '(22Welch': [932], 'Rosenblatt': [934], 'Skoble': [936], 'Portnoy': [938], 'Mitchison': [940, 4767, 4968], 'Science.': [942, 4534], '281:': [944], '105-108Crossref': [945], '(421)': [948], 'uses': [952], 'force': [953], 'generated': [954], 'propel': [959], 'itself': [960, 985], 'around': [961], 'cytoplasm': [963, 1529], 'eukaryotic': [965], 'ActA': [967, 978, 4701], 'only': [970, 1670, 2372, 4453, 5561], 'bacterial': [971], 'induce': [975], 'polymerization,': [976, 3497, 3723, 4359], 'cannot': [979, 2243], 'stimulate': [980, 3796, 5582], 'formation': [983, 1799, 1950, 5448, 5584], '23Cossart': [989], 'P.': [990, 2365, 2597, 2791, 2795], 'Lecuit': [991], '17:': [996, 1904, 5061, 5202, 5406, 5422], '3797-3806Crossref': [997], '(249)': [1000], 'work': [1004, 3171, 3701, 4999], 'suggested': [1005, 1404, 2202], 'activate': [1010, 3309, 3735, 3892, 3993, 4030, 4465, 4615, 4817, 4828], 'actin.': [1015], 'year': [1017], 'WASp/Scar': [1018, 1640, 1937, 1996, 2331, 2373, 2494, 3307, 3596, 3645, 3769, 4040, 4055, 4065, 4276, 4415, 4458, 4511, 4578, 4684, 4785, 4818, 5014, 5084, 5357, 5366, 5580, 5594], 'identified': [1021], 'first': [1024, 1556, 3325], 'example': [1025], '(24Machesky': [1029, 2127, 2170, 3181, 3870, 4380, 5018, 5130], 'Insall': [1031, 2129, 2172, 3180, 3183, 3872, 4382, 5020, 5132], 'R.H.': [1032, 2130, 2173, 3184, 3873, 4383, 5021, 5133], '1347-1356Abstract': [1037, 2135, 2178, 3189, 3878, 4388, 5026, 5138], '(756)': [1045, 2143, 2186, 3197, 3886, 4396, 5034, 5146], '25Machesky': [1048], 'Higgs': [1052, 2008, 3280, 3805, 3898, 3969, 5453], 'H.N.': [1053, 2009, 3281, 3806, 3899, 5454], 'Kaiser': [1054, 2010, 3282, 3807, 3900, 5455], 'Blanchoin': [1056, 2012, 3284, 3809, 3902, 5457], 'L.': [1057, 1082, 1256, 1275, 2013, 2038, 2550, 2699, 2767, 2950, 2960, 3143, 3285, 3743, 3810, 3903, 3942, 4103, 4479, 4546, 4837, 5306, 5458], 'May': [1058, 2014, 3286, 3811, 3904, 5459], 'R.C.': [1059, 2015, 2779, 3287, 3812, 3905, 5460], 'Hall': [1060, 2016, 3288, 3813, 3906, 5461], 'M.E.': [1061, 2017, 3289, 3814, 3907, 5462], '3739-3744Crossref': [1073, 2029, 3301, 3826, 3919, 5474], '(617)': [1076, 2032, 3304, 3829, 3922, 5477], '26Rohatgi': [1079, 2035], 'Ma': [1081, 2037, 2549, 3142, 3941, 4478, 4836], 'Miki': [1083, 2039, 2551, 3144, 3943, 4480, 4838, 5415], 'H.': [1084, 1230, 1781, 1808, 1896, 2040, 2307, 2533, 2552, 2576, 2679, 2829, 2843, 2890, 2907, 3119, 3145, 3944, 4481, 4839, 5037, 5053, 5161, 5177, 5194, 5210, 5246, 5398, 5416], 'Lopez': [1085, 2041, 2553, 3146, 3945, 4482, 4840], 'Kirchhausen': [1087, 2043, 2555, 3148, 3947, 4484, 4842], 'T.': [1088, 1090, 1110, 1234, 1443, 1785, 1810, 1814, 1900, 2044, 2046, 2066, 2309, 2405, 2535, 2556, 2558, 2580, 2683, 2815, 2823, 2827, 2833, 2876, 2884, 2888, 2894, 3123, 3149, 3151, 3746, 3948, 3950, 3971, 4002, 4485, 4487, 4843, 4845, 5041, 5057, 5165, 5179, 5183, 5198, 5212, 5248, 5252, 5402, 5418], 'Takenawa': [1089, 1233, 1784, 1813, 1899, 2045, 2308, 2534, 2557, 2579, 2682, 3122, 3150, 3949, 4486, 4844, 5040, 5056, 5164, 5182, 5197, 5211, 5251, 5401, 5417], 'Kirschner': [1091, 1261, 1278, 2047, 2559, 3152, 3951, 4106, 4488, 4846], 'M.W.': [1092, 1262, 1279, 2048, 2560, 3153, 3952, 4107, 4489, 4847], '97:': [1095, 2051, 2563, 3156, 3955, 4492, 4850], '221-231Abstract': [1096, 2052, 2564, 3157, 3956, 4493, 4851], '(1082)': [1104, 2060, 2572, 3165, 3964, 4501, 4859], '27Winter': [1107, 2063], 'Lechler': [1109, 2065, 2404, 4001], '9:': [1116, 1139, 1369, 1500, 2072, 2095, 2411, 4008, 4130, 4269], '501-504Abstract': [1117, 2073, 2412, 4009], '(192)': [1125, 2081, 2420, 4017], '28Yarar': [1128, 2084], 'To': [1130, 2086, 3319], 'W.': [1131, 2087, 2857], 'Abo': [1132, 1751, 2088, 2516, 2598], '555-558Abstract': [1140, 2096], '(222)': [1148, 2104], 'These': [1151, 2393, 2457, 4598, 5592], 'interact': [1154, 2166, 2492, 3206, 4790], 'signaling': [1160, 4408, 4530, 5603], 'molecules': [1161, 4531, 4813], 'influence': [1164, 1723, 4528], 'cytoskeletal': [1165, 1870], 'dynamics,': [1166], 'bringing': [1167], 'us': [1168], 'closer': [1169], 'forging': [1171], 'connection': [1173], 'between': [1174, 2347, 4659], 'receptor': [1176, 1844, 4362, 4587, 4663, 4806], 'polymerization.': [1180, 1663, 3382], 'rapid': [1182, 3414, 5243], 'progress': [1183], 'reviewed': [1184, 1486], 'here': [1185, 5577], 'depended': [1186], 'upon': [1187], 'groundwork': [1188], 'laboratories.': [1191], 'Analysis': [1192, 1548], 'Wiskott-Aldrich': [1194, 1677], 'syndrome': [1195], '(WASp)': [1197], 'its': [1199, 1831, 2334, 3677, 4448, 5351], 'neural': [1200], 'homolog': [1201, 3048], 'N-WASP': [1202, 1770, 2146, 2209, 2430, 3117, 3139, 3929, 4466, 4613, 4629, 5152, 5229, 5394], 'revealed': [1203], 'binding': [1205, 1704, 2126, 2303, 2983, 3011, 3174, 4063], 'site': [1206, 3175], 'Rho': [1208, 1384, 1720, 2440], 'family': [1209, 1385, 1641, 1721, 2441, 5367], 'GTPases': [1210, 1722, 2442], 'other': [1212, 1514, 1921, 2330, 2480, 3978, 4039, 4086, 4295, 4574, 4622, 4706, 5271, 5618], 'domains': [1213], 'affect': [1215, 4440], 'assembly': [1217, 1418], '(29Ochs': [1220, 1691], 'H.D.': [1221, 1692], 'Semin.': [1222, 1693], 'Hematol.': [1223, 1694], '35:': [1225, 1696], '332-345PubMed': [1226, 1697], '30Miki': [1229, 2575], 'Miura': [1231, 1782, 2577, 2680, 3120, 5038, 5162], 'K.': [1232, 1323, 1783, 2578, 2681, 2819, 2880, 2911, 3121, 5039, 5163], '5326-5335Crossref': [1239, 1790, 2585, 2688, 3128, 5046, 5170], '(556)': [1242, 1793, 2588, 2691, 3131, 5049, 5173], 'Study': [1245], 'GTPγS1-stimulated': [1247], 'extracts': [1251, 4097], 'vertebrate': [1253, 1776], '(31Ma': [1255], 'Cantley': [1257], 'L.C.': [1258], 'Janmey': [1259], 'P.A.': [1260], '140:': [1267], '1125-1136Crossref': [1268], '(168)': [1271], '32Ma': [1274], 'Rohatgi': [1276, 4104], '15362-15367Crossref': [1289, 4117], '(154)': [1292, 4120], '33Zigmond': [1295], 'Joyce': [1297, 1318, 1341], 'Borleis': [1299, 1343], 'Bokoch': [1301, 1345], 'G.M.': [1302, 1346], 'Devreotes': [1303, 1347], 'P.N.': [1304, 1348], '138:': [1309, 1353, 1450, 4773, 4974], '363-374Crossref': [1310, 1354], '(145)': [1313, 1357], '34Zigmond': [1316], 'Yang': [1320], 'C.': [1321, 2777, 2913], 'Brown': [1322], 'Huang': [1324], 'Pring': [1326], '142:': [1332, 1855], '1001-1012Crossref': [1333], '(65)': [1336], 'Scholar),Dictyostelium': [1338], '(33Zigmond': [1339], 'Acanthamoeba': [1361], '(35Mullins': [1362], '405-415Abstract': [1370, 4131], '(62)': [1378, 2291, 4139], 'demonstrated': [1381, 4454], 'GTPase': [1386], 'Cdc42': [1387, 1709, 1803, 2443, 4461, 4506, 4583, 4607], 'mediates': [1388], 'effect': [1390, 4637], 'GTP': [1392], 'required.': [1398], 'Similar': [1399], 'experiments': [1400, 3693, 4297], 'extracted': [1402], 'yeast': [1403, 3989, 3996, 4031, 4148, 4300], 'Bee1p': [1406, 2369, 2401, 3990, 4028], '(a': [1407], 'homolog)': [1409], 'patch': [1417, 1949, 4145], '(20Winter': [1419, 4149], '36Lechler': [1442], '95-103Crossref': [1451], '(51)': [1454], '37Li': [1457], '136:': [1463, 1960, 4991], '649-658Crossref': [1464, 1961], '(219)': [1467, 1964], 'contains': [1473, 2210, 3248], 'copy': [1475], 'seven': [1479, 4368], 'associated': [1481], '(Fig.': [1484, 2237, 3317, 3611, 3685, 5076, 5381], '1;': [1485], 'detail': [1488], '38Mullins': [1491], 'Opin.': [1496], 'Struct.': [1497, 2284], '244-249Crossref': [1501], '(93)': [1504], 'Arp2': [1507, 1553, 4305], 'Arp3': [1509, 1555, 4307], 'actin-related': [1511], 'proteins.': [1512, 2332, 4041, 4597], 'five': [1515, 1645], 'novel.': [1518], 'very': [1522, 3338], 'abundant,': [1523], 'μm': [1526], 'ofAcanthamoeba': [1530], 'molecular': [1550], 'models': [1551], 'led': [1557], 'hypothesis': [1560, 3684, 4379, 5226], 'they': [1562, 2254, 3615, 4619, 4686, 4826], 'stable': [1565, 3428], 'dimer': [1566], 'binds': [1568, 1605, 3112, 3761, 5015, 5098], 'nucleates': [1576], 'Polymerization': [1599], 'assays': [1600], 'established': [1601], 'nanomolar': [1610], 'affinity': [1611], 'modest': [1614], 'activity': [1616, 2468, 4443], 'mammalian': [1639, 1873], 'currently': [1642], 'consists': [1643], 'members:': [1646], 'WASp,': [1647, 1667], 'N-WASP,': [1648], 'Scar': [1651, 1824, 1864, 3240, 3257, 4652, 4660], 'isoforms': [1652, 4728], '(Fig.2).': [1653], 'Several': [1654], 'lines': [1655, 4070], 'implicate': [1658], 'gene': [1665, 1832], 'encoding': [1666], 'apparently': [1668, 3111], 'expressed': [1669, 1772], 'hematopoietic': [1672], 'mutated': [1675], 'syndrome,': [1678], 'X-linked': [1680], 'human': [1681, 1922, 3202, 3862, 5095], 'disease': [1682], 'selective': [1684], 'defects': [1685], 'development': [1688], 'lymphocytes': [1690], 'presence': [1701, 3853, 5494], 'motif': [1705], '(GBD)': [1706], 'activated': [1708], 'Rac': [1711], 'hinted': [1712], 'regulate': [1716, 2465, 4590, 4689], 'actin,': [1717, 2482, 3695], 'because': [1718, 1727, 2251, 3340, 3397, 3412, 4518, 4808, 5556], 'dynamics': [1725, 5299], 'transfection': [1728], 'rearranges': [1731], 'cultured': [1735, 1805, 3229], '(39Symons': [1737], 'Derry': [1739, 2504], 'J.M.J.': [1740, 2505], 'Kariak': [1741, 2506], 'Jiang': [1743, 2508], 'Lemahieu': [1745, 2510], 'McCormick': [1747, 2512], 'Francke': [1749, 2514], '723-734Abstract': [1756, 2521], '(749)': [1764, 2529], 'homologue': [1769, 1874], 'more': [1773, 2367, 3169, 3840, 5379, 5487], 'widely': [1774], '(30Miki': [1780, 3118, 5160], 'causes': [1797, 1869], 'filopodial': [1798], 'co-expressed': [1801], '(40Miki': [1807, 5245], 'Sasaki': [1809, 5178, 5247], 'Takai': [1811, 5180, 5249], 'Y.': [1812, 2809, 2870, 2917, 2919, 5181, 5250], '391:': [1817, 5186, 5255], '93-96Crossref': [1818, 5187, 5256], '(567)': [1821, 5190, 5259], 'inDictyostelium': [1827], 'disruption': [1829, 1839], 'rescues': [1833], 'developmental': [1835], 'defect': [1836], 'caused': [1837], 'cyclic': [1842], 'AMP': [1843], '(41Bear': [1845], 'Rawls': [1847], 'Saxe': [1849], 'C.L.': [1850], '1325-1335Crossref': [1856], '(233)': [1859], 'Deletion': [1862], 'wild': [1866], 'type': [1867], 'defects.': [1871], 'Scar,': [1876], 'termed': [1877], 'WAVE': [1878], 'Scar1,': [1880], 'involved': [1883], 'Rac-induced': [1885], 'ruffling,': [1887], 'although': [1888, 2224, 4312, 4656], 'does': [1890, 3604, 3890, 4143, 4512, 5117, 5512], 'contain': [1892, 5369], 'GBD': [1894], '(42Miki': [1895, 5397], 'Suetsugu': [1897, 5054, 5195, 5399], '6932-6941Crossref': [1905, 5062, 5203, 5407], '(576)': [1908, 5065, 5206, 5410], 'No': [1911, 2475], 'information': [1912], 'yet': [1914], 'available': [1915], 'functions': [1918], 'two': [1920, 2148, 2191, 2339, 2995, 3023, 3447, 4725], 'Scar-related': [1923], 'open': [1924], 'reading': [1925], 'frames': [1926], '(GenBank': [1927], 'accession': [1928], 'numbers': [1929], 'BAA74923': [1930], 'CAA18609).': [1932], 'cerevisiae,': [1935], 'homologue,': [1938], 'Las17p': [1941], 'Bee1p,': [1943], 'essential': [1945, 4309], 'cortical': [1947, 4869], 'endocytosis': [1953], '(37Li': [1954], '43Naqvi': [1967], 'S.N.': [1968], 'Zahn': [1969], 'Mitchell': [1971], 'Stevenson': [1973], 'B.J.': [1974], 'Munn': [1975], '959-962Abstract': [1981], 'C-terminal': [1991, 2153, 2378, 2388, 3593], '65–105': [1992], 'amino': [1993], 'acids': [1994], '(Fig.3)': [1998], 'enhance': [1999, 5514], '(25Machesky': [2004, 3276, 3801, 3894, 5449], 'region': [2108, 2205, 2300, 2346, 3860, 3982, 4047], 'starts': [2109], '(WH2)': [2115], 'motif,': [2116, 2336], '16–19-amino': [2118], 'acid': [2119], 'sequence': [2120, 2213, 2229, 2359, 3090], 'participates': [2122, 2301], 'monomer': [2125, 4062, 5276], 'tandem': [2149], 'motifs.': [2151, 3254], '15–20': [2154], 'residues,': [2155], 'designated': [2156], '"A,"': [2157], 'generally': [2158], 'possess': [2159], 'negative': [2162], 'net': [2163, 2383], 'charge': [2164, 2385], 'Between': [2189], 'regions': [2192, 3790, 3927], '30–40': [2194], 'residues': [2195, 2380], 'unknown': [2197, 2343], 'functional': [2198, 2398, 4054], 'significance.': [2199, 2344], 'Some': [2200], 'have': [2201, 2381, 2487, 3032, 3407, 4621], 'short': [2212, 2241], 'similar': [2214, 3069], 'cofilin': [2220], '("cofilin': [2221], 'domain"),': [2223], 'our': [2226, 3703, 5093, 5279], 'opinion': [2227], 'similarity': [2230], 'too': [2232], 'limited': [2233], 'indicate': [2235], '3).': [2238, 2392], 'Furthermore,': [2239], 'sequences': [2242, 5355], 'usual': [2249], 'sense,': [2250], 'ADF/cofilins': [2253], 'part': [2256, 2263], 'β-strand,': [2259], 'loop,': [2261], 'α-helix': [2266, 3100], 'rather': [2267, 4873], 'independently': [2270], 'folded': [2271], 'structure': [2272, 3042], '(44Leonard': [2273], 'S.A.': [2274], 'Gittis': [2275], 'A.G.': [2276], 'Petrella': [2277], 'E.C.': [2278], 'Lattman': [2281], 'E.E.': [2282], 'Nat.': [2283], '4:': [2287], '369-373Crossref': [2288], 'However,': [2294, 4697, 4862, 5079, 5262], 'there': [2295], 'monomers': [2305, 3335, 3424], '(45Miki': [2306], 'Res.': [2312, 2538, 5215], 'Commun.': [2313, 2539, 5216], '243:': [2315, 2541, 5218], '73-78Crossref': [2316, 2542, 5219], '(116)': [2319, 2545, 5222], 'C': [2323, 5011, 5085], 'terminus': [2324, 5012], 'Las17p/Bee1p': [2326], 'differs': [2327, 2352], 'significantly': [2328, 3601], 'unique': [2340], 'inserts': [2341], 'motifs': [2351], 'even': [2353, 3584], 'more,': [2354], '>50%': [2356], 'G,': [2362], 'A,': [2363], 'Perhaps': [2366], 'importantly,': [2368], '20': [2379], 'neutral': [2384], '(excluding': [2386], 'carboxyl': [2389], 'group,': [2390], 'Fig.': [2391], 'differences': [2394, 2399], 'explain': [2396], '(27Winter': [2402, 3999], 'N-terminal': [2423, 3034, 3114, 3986], 'nucleation-activating': [2426], 'region,': [2427], 'bind': [2431, 3092, 3108, 3774, 4815, 5087], 'impressive': [2433], 'list': [2434], 'ligands': [2437, 5528], '(TableI):': [2438], 'Rac,': [2445], 'WASp-interacting': [2446, 2998, 3026, 4563], 'protein,': [2447, 4564], 'calmodulin,': [2448, 4570], 'Src': [2449, 4566, 4642], 'kinases,': [2450, 2452, 4567, 4569], 'Tec': [2451, 4568, 4644], 'Grb2,': [2453, 4565], 'Nck,': [2454], 'profilin.': [2456, 3857, 5504], 'myriad': [2461], 'possibilities': [2463], 'either': [2466, 3776, 3850, 4289, 4441], 'location': [2470], 'N-WASP.': [2474], 'interacting': [2476], 'Scar1': [2479, 3205, 3792, 3863, 5127, 5155, 5285, 5396, 5480, 5490], 'profilin,': [2483, 5496], 'identified.Table': [2489], 'IMolecules': [2490], 'proteinsMoleculeWASp/Scar': [2495], 'partnerBinding': [2496], 'regionEvidenceEffect': [2497], 'nucleationRefs.Cdc42/RacWASp,': [2499], 'N-WASPGBD,': [2500], 'other?BO,': [2501], 'BAStimulates26,39Symons': [2502], '45Miki': [2532, 5209], 'ScholarPIP2N-WASPWH1?BAStimulates26Rohatgi': [2547], 'ScholarWIPWASp,': [2590], 'Beelp101–151': [2591], '(WASp)TH,': [2592], 'GST,': [2593, 2985, 3013], 'IP?46Rudolph': [2594], 'M.G.': [2595], 'Bayer': [2596], 'Kuhlman': [2600], 'Vetter': [2602], 'I.R.': [2603], 'Wittinghofer': [2604], 'Chem.': [2608, 2965, 4549, 5311], '273:': [2610, 2967, 5313], '18067-18076Abstract': [2611], '(124)': [2619, 2733, 2762], '47Ramesh': [2622], 'N.': [2623, 3741, 3968], 'Anton': [2624], 'I.M.': [2625], 'Hartwig': [2626], 'J.H.': [2627, 2932], 'Geha': [2628], 'R.S.': [2629], '94:': [2638], '14671-14676Crossref': [2639], '(309)': [2642], '65Beckerle': [2645], 'M.C.': [2646, 5537], '741-748Abstract': [2650, 5541], '(92)': [2658, 5549], '66Vaduva': [2661], 'N.C.': [2664], 'Hopper': [2665], 'A.K.': [2666], '1821-1833Crossref': [2672], '(105)': [2675], 'ScholarCalmodulinN-WASPIQGST,': [2677], 'IP?30Miki': [2678], 'ScholarSrc': [2693], 'kinasesWASpPolyprolineGST,': [2694, 2736], 'IP,': [2695, 2737, 2989, 3017], 'P?48Stewart': [2696], 'Tian': [2698, 2949], 'Nelson': [2700, 2951], 'D.L.': [2701, 2952], 'Immunol.': [2703, 2781, 2954], '162:': [2705, 2956], '5019-5024PubMed': [2706, 2957], '49Banin': [2709], 'Truong': [2711, 2740], 'O.': [2712, 2741], 'Katz': [2713, 2742], 'D.R.': [2714, 2743], 'Waterfield': [2715, 2744], 'Brickell': [2717, 2746, 2772], 'P.M.': [2718, 2747, 2773], 'Cout': [2719, 2748], 'I.': [2720, 2749, 2771], '6:': [2724, 2753], '981-989Abstract': [2725, 2754], 'ScholarTec': [2735], 'P?49Banin': [2738], 'Scholar–51Cory': [2764], 'G.O.C.': [2765], 'MacCarthy-Morrogh': [2766], 'Banin': [2768], 'Gout': [2770], 'Levinsky': [2774], 'R.J.': [2775], 'Kinnon': [2776], 'Lovering': [2778], '157:': [2783], '3791-3795PubMed': [2784], 'ScholarGrb2WASp,': [2786], 'N-WASpPolyprolineGST,': [2787], 'IP?50Guinamard': [2788], 'Aspenstrom': [2790], 'Fougereau': [2792], 'Chavrier': [2794], 'Guillemot': [2796], 'J.C.': [2797], 'FEBS': [2798], 'Lett.': [2799], '434:': [2801], '431-436Crossref': [2802], '(94)': [2805], '52Baba': [2808], 'Nonoyama': [2810, 2871], 'Matsushita': [2812, 2873], 'Yamadori': [2814, 2875], 'Hashimoto': [2816, 2877], 'Imai': [2818, 2879], 'Arai': [2820, 2881], 'Kunikata': [2822, 2883], 'Kurimoto': [2824, 2885], 'Kurosaki': [2826, 2887], 'Ochs': [2828, 2889, 2906], 'Yata': [2830, 2891], 'Kishimoto': [2832, 2893], 'Tsukada': [2834, 2895], 'Blood.': [2836, 2897, 2920], '93:': [2838, 2899], '2003-2012Crossref': [2839, 2900], 'Scholar,53She': [2842], 'Rockow': [2844], 'Tang': [2846], 'Nishimura': [2848], 'Skolnik': [2850], 'Chen': [2852], 'Margolis': [2854], '1709-1721Crossref': [2863], '(106)': [2866], 'ScholarNckWASpPolyprolineGST,': [2868], 'IP?52Baba': [2869], '54Oda': [2904], 'Druker': [2908], 'D.J.': [2909, 3078], 'Ozaki': [2910], 'Watanabe': [2912], 'Handa': [2914], 'Miyakawa': [2916], 'Ikeda': [2918], '92:': [2922], '1852-1858Crossref': [2923], '55Rivero-Lezcano': [2927], 'O.M.': [2928], 'Marcilla': [2929], 'Sameshima': [2931], 'Robbins': [2933], 'K.C.': [2934], '5725-5731Crossref': [2940], '(280)': [2943], 'ScholarProfilinN-WASP,': [2945], 'Scar1PolyprolineGST,': [2946], 'IP?48Stewart': [2947], 'Scholar,63Blanchoin': [2959], '25106-25111Abstract': [2968, 5314], '(144)': [2976, 5322], 'ScholarBO,': [2978], 'blot': [2979, 3007], 'overlay;': [2980, 3008], 'BA,': [2981, 3009], 'direct': [2982, 3010], 'assay;': [2984, 3012], 'GST': [2986, 3014], 'fusion': [2987, 3015], 'pulldown;': [2988, 3016], 'co-immunoprecipitation;': [2990, 3018], 'P,': [2991, 3019], 'phosphorylates': [2992, 3020], 'WASp/Scar;': [2993, 3021], 'TH,': [2994, 3022], 'hybrid;': [2996, 3024], 'WIP,': [2997, 3025], 'protein.': [2999, 3027], 'Open': [3000], 'table': [3001], 'tab': [3005], 'BO,': [3006], 'N-WASp': [3030], '(WH1).': [3039], 'An': [3040], 'atomic': [3041], 'EVH1': [3045, 3093], 'domain,': [3046], 'WH1': [3051], 'found': [3053, 3101, 3200], 'adapter': [3055], 'including': [3057], 'Ena': [3058], 'VASP,': [3060], 'shows': [3061], 'fold': [3064], 'pleckstrin': [3072, 3103], '(57Prehoda': [3075], 'K.E.': [3076], 'Lee': [3077], 'Lim': [3079], 'W.A.': [3080], '(in': [3083], 'press)PubMed': [3084], 'Ligands': [3087], 'FPPPP': [3091], 'place': [3096], 'intrinsic': [3099], 'domains,': [3105], 'PIP2.': [3109, 4463], 'PIP2': [3110, 4508], 'construct': [3115], 'activates': [3135], 'full-length': [3138], '(26Rohatgi': [3140, 3939, 4476, 4834], 'detailed': [3170, 3700, 4043], 'defining': [3172], 'needed.': [3177], 'p21': [3209, 3868], 'subunit': [3210, 3869], 'two-hybrid': [3212], 'assay': [3213], 'whole': [3217], 'assays.': [3221], 'Introduction': [3222], 'pieces': [3224], 'disrupts': [3231], 'ruffling': [3233], 'delocalizes': [3235], 'complex.': [3237, 3590, 4696, 5519, 5591], 'minimum': [3239], 'fragment': [3241, 3258], 'sufficient': [3242], 'effects': [3245], '(WA)': [3253], 'same': [3256, 4604], 'greatly': [3259], 'enhances': [3260, 3676, 5389], 'complex,': [3265, 4617], 'reducing': [3266], 'lag': [3268, 3376, 3385, 3582, 3608, 3649, 3691, 3708], 'time': [3269], 'increasing': [3271, 5435], 'number': [3273, 3431, 3460, 3619, 4678], '4).': [3318], 'understand': [3320], 'must': [3324], 'appreciate': [3326], 'behaves': [3329, 5128], 'itself.': [3331], 'Nucleation': [3332], 'alone': [3336, 3495, 4687], 'unfavorable': [3339], 'instability': [3343], 'dimers': [3346, 3417, 3564, 3572], 'trimers,': [3348], 'obligate': [3349], 'intermediates': [3350], 'pathway': [3353, 4428], 'Ref.4Pollard': [3358], 'Unfavorable': [3371], 'accounts': [3373, 3555], 'onset': [3379], 'During': [3383], 'trimers': [3386], 'immediately,': [3388], 'bulk': [3391], 'rate': [3392, 3482, 3484, 5499, 5568], 'low': [3396, 3561], 'nuclei': [3402], 'exceedingly': [3404], 'low.': [3405], 'Trimers': [3406], 'lifetime': [3409], 'microseconds': [3411], 'dissociation': [3415, 3567], 'rare': [3420], 'addition': [3421, 3545], 'filament.': [3429, 3579, 3682], 'accumulates': [3434], 'reaction,': [3437, 3452], 'mainly': [3438], 'infrequent': [3444], 'breaks': [3445], 'filaments.': [3448], 'Early': [3449], 'annealing': [3456], 'consumes': [3457], 'significant': [3459], 'At': [3464], 'any': [3465, 4457], 'point': [3466], 'reaction': [3469, 3500, 3844], 'calculated': [3478], '(polymerization': [3483], '=': [3485], '[ends]((k': [3486], '+)': [3487], '[actin': [3488], 'monomers]': [3489], '−': [3490], '(k': [3491], '−)).': [3492], 'inefficient': [3502], 'kinetic': [3525], 'data': [3526, 5264], 'best': [3528], 'fit': [3529], 'captures': [3536], 'dimers,': [3538], 'then': [3540], 'end.': [3552], 'inefficiency': [3558], '98%': [3569], 'captured': [3571], 'before': [3576, 3777], 'producing': [3577], 'initial': [3581], 'persists': [3583], 'high': [3586], 'concentrations': [3587], 'Addition': [3591, 3635], 'constructs': [3594, 3646], 'decreases': [3602], 'eliminate': [3606], '4': [3612, 3686, 5077], 'A).': [3613, 3653], 'Together': [3614], 'increase': [3617, 3628], 'ends,': [3622], 'reflected': [3624], 'large': [3627, 4677], 'slope': [3630], 'curve.': [3634], 'preformed': [3637], 'along': [3640, 4720], 'reduces': [3647, 5432], 'still': [3650, 3757], 'further': [3651], '(Fig.4': [3652], 'result': [3655], 'suggests': [3656, 3705, 4666, 5386], 'fundamentally': [3663], 'correct;': [3664], 'association': [3665, 3780], 'B)': [3687], 'explains': [3688], 'persistent': [3690], 'Arp2/3,': [3696], 'WASp/Scar.': [3698], 'More': [3699, 4042], 'laboratory': [3704], 'due': [3715], 'buildup': [3718], 'threshold': [3726], '<100': [3728], 'nm': [3729], 'needed': [3733, 4049], 'WASp.': [3739], '2H.': [3740], 'Higgs,': [3742], 'Blanchoin,': [3744], 'Pollard,': [3748, 3973], 'submitted': [3749], 'publication.': [3751], 'order': [3753], 'events': [3755], 'unclear;': [3758], 'sides': [3764], 'WA,': [3770], 'could': [3773, 4600, 5267, 5560], 'after': [3779], 'WA': [3782, 5097, 5153, 5156, 5230, 5283, 5286, 5491], 'subunits.': [3785], 'adjacent': [3833], 'polyproline': [3834], 'favor': [3837], 'steps': [3841], 'absolutely': [3848], 'absence': [3855], 'interacts': [3864], 'directly': [3865], 'insufficient': [3934], '3H.': [3967], 'unpublished': [3974], 'observations.': [3975], 'On': [3976, 4293], 'hand,': [3979, 4296], '(with': [3983, 5482], 'undefined': [3985], 'boundary)': [3987], 'appears': [3991], 'unlikely': [4021], 'given': [4022, 5616], 'conservation': [4024], 'molecules,': [4027], 'different': [4036, 4403], 'way': [4037, 4605, 5081], 'dissection': [4044], 'determine': [4051], 'minimal': [4053], 'unit': [4056], 'role': [4059, 4080, 4668, 5349], 'nucleation.': [4068, 5572], 'Two': [4069], 'suggest': [4073, 4301], 'plays': [4077], 'do': [4082], 'rule': [4084], 'out': [4085], 'pathways.': [4087, 4303, 5604], 'First,': [4088], 'GTP-stimulated': [4092], 'depends': [4098], '(32Ma': [4102], '35Mullins': [4123], 'reconstitution': [4146], 'Second,': [4172], 'keratocytes': [4182], 'fibroblasts': [4184], 'incorporated': [4186], '70°': [4188], 'networks': [4190, 4235, 5641], 'localized': [4194], '(13Svitkina': [4198], 'affinities': [4214], 'allow': [4228], 'branched': [4234], '58Mullins': [4257], 'Kelleher': [4259], 'Xu': [4261], '841-852Crossref': [4270], 'stabilize': [4288, 5070], 'associations.': [4292], 'budding': [4299], 'alternative': [4302], 'Neither': [4304], 'nor': [4306, 5284], 'viability,': [4311], 'null': [4313], 'strains': [4314], 'extremely': [4316], 'sick': [4317], 'phenotype': [4320], 'depend': [4322], 'genetic': [4325], 'background': [4326, 5433], 'particular': [4329, 4412, 4631], 'strain': [4330], '(21Winter': [4331], 'stimuli': [4355], 'regulates': [4356], 'acting': [4360], 'tyrosine': [4363, 4521], 'kinase/mitogen-activated': [4364], 'kinase': [4366, 4522], 'pathways,': [4367, 4517], 'helix': [4369], 'receptors,': [4370, 4520, 4523], 'integrins.': [4372], 'Details': [4373], 'remain': [4374], 'unclear,': [4375], 'kinds': [4404], 'receptors': [4406, 4671, 4823], 'converge': [4410], 'members': [4413, 5368], 'funnel': [4418], 'final': [4426], 'common': [4427], 'formation.': [4432], 'Any': [4433, 4636], 'could,': [4437], 'principle,': [4439], 'localization': [4449], 'activators': [4455, 4653, 4792], 'Both': [4464], 'Participation': [4504], 'activating': [4510], 'restrict': [4514], 'upstream': [4516], 'seven-helix': [4519, 4670], 'integrins': [4525], '(59Hall': [4532], '279:': [4536], '509-514Crossref': [4537], '(5230)': [4540], '60Pike': [4543], 'L.J.': [4544], 'Casey': [4545], '271:': [4551], '26453-26456Abstract': [4552], '(332)': [4560], 'Nck': [4572], 'potential': [4575, 4680, 5373, 5483], 'regulators': [4576], '(Table': [4580], 'I).': [4581], 'Like': [4582], 'PIP2,': [4585, 4609], 'multiple': [4586], 'classes': [4588], 'if': [4592], 'act': [4601], 'enabling': [4610], 'roles': [4623], 'targeting': [4626], 'parts': [4632], 'cell.': [4635], 'phosphorylation': [4640], 'kinases': [4645], 'entirely': [4647], 'unclear.': [4648, 5365], 'identity': [4650], 'unknown,': [4655], 'link': 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5375, 5535, 5648], 'activation.': [5009], 'Scholar,30Miki': [5036], '42Miki': [5052, 5193], 'nascent': [5072], 'B).': [5078], 'termini': [5086], 'clear.': [5091], 'hands,': [5094, 5280], 'K': [5103], 'd': [5104], 'about': [5106], '0.5': [5107], 'μm.': [5108], 'inhibits': [5110, 5571], 'elongation': [5111, 5244, 5330, 5534, 5567], 'inhibit': [5119], 'sequester': [5124], 'monomers.2': [5126, 5291], 'similarly': [5129], 'Others': [5149], 'find': [5150], 'depolymerize': [5157], '40Miki': [5176], 'One': [5225, 5520], 'severs': [5234, 5287], 'thereby': [5237], 'exposing': [5238], 'interpreted': [5269], 'ways,': [5272], 'sequestration.': [5277], 'neither': [5281], 'sequesters': [5290], 'Profilin': [5292], 'thought': [5294], 'participate': [5296], 'nucleotide': [5302], 'exchange': [5303], 'factor': [5304], '(63Blanchoin': [5305], 'carrier': [5326], '(64Pantaloni': [5331], 'Carlier': [5333], 'M.F.': [5334], '1993;': [5336], '75:': [5337], '1007-1014Abstract': [5338], '(460)': [5344], 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[5634], 'disassembled': [5643], 'recycle': [5645], 'growth.': [5650]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2013121253', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-12T15:24:19.938196', 'created_date': '2016-06-24'}
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