Title: Inhibition of Spindle Assembly by Colchicine and of Cell Cycle by Cycloheximide
Abstract:In cleavage mitoses colchicine (2 × 10<sup>-3</sup><i>M) </i>does not interrupt the cycle of chromatin and its action is exerted on all the mitotic phases. Cycloheximide (10<...In cleavage mitoses colchicine (2 × 10<sup>-3</sup><i>M) </i>does not interrupt the cycle of chromatin and its action is exerted on all the mitotic phases. Cycloheximide (10<sup>-3</sup><i>M) </i>prevents normal condensation of the chromosomes and breakdown of the nuclear envelope; it brings on various nuclear abnormalities, particularly irregularities in chromosome condensation. At 10<sup>-4</sup><i>M, </i>cycloheximide allows some mitoses, often abnormal ones, but anaphase is inhibited. The action of colchicine, more efficient upon the spindle, obscures the action of cycloheximide when both substances are associated. In return, cycloheximide imposes its action upon chromosome condensation, so that the structure of the nuclei treated by both substances is determined by cycloheximide.Read More
Publication Year: 1979
Publication Date: 1979-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 7
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