Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2012789061', 'doi': 'https://doi.org/10.1038/jcbfm.2009.46', 'title': 'Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury', 'display_name': 'Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury', 'publication_year': 2009, 'publication_date': '2009-04-29', 'ids': {'openalex': 'https://openalex.org/W2012789061', 'doi': 'https://doi.org/10.1038/jcbfm.2009.46', 'mag': '2012789061', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19401709', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2846547'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/jcbfm.2009.46', 'pdf_url': 'https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2009.46', 'source': {'id': 'https://openalex.org/S89339265', 'display_name': 'Journal of Cerebral Blood Flow & Metabolism', 'issn_l': '0271-678X', 'issn': ['0271-678X', '1559-7016'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2009.46', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5065360220', 'display_name': 'Juan Pablo de Rivero Vaccari', 'orcid': 'https://orcid.org/0000-0002-5460-8834'}, 'institutions': [{'id': 'https://openalex.org/I4210157890', 'display_name': 'Neurological Surgery', 'ror': 'https://ror.org/04r0gp612', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210157890']}, {'id': 'https://openalex.org/I145608581', 'display_name': 'University of Miami', 'ror': 'https://ror.org/02dgjyy92', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145608581']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Juan Pablo de Rivero Vaccari', 'raw_affiliation_strings': ['Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA', 'Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA', 'institution_ids': ['https://openalex.org/I4210157890', 'https://openalex.org/I145608581']}, {'raw_affiliation_string': 'Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA', 'institution_ids': ['https://openalex.org/I145608581', 'https://openalex.org/I4210157890']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023593112', 'display_name': 'George Lotocki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145608581', 'display_name': 'University of Miami', 'ror': 'https://ror.org/02dgjyy92', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145608581']}, {'id': 'https://openalex.org/I4210157890', 'display_name': 'Neurological Surgery', 'ror': 'https://ror.org/04r0gp612', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210157890']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'George Lotocki', 'raw_affiliation_strings': ['Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA', 'Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA', 'institution_ids': ['https://openalex.org/I145608581', 'https://openalex.org/I4210157890']}, {'raw_affiliation_string': 'Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA', 'institution_ids': ['https://openalex.org/I145608581', 'https://openalex.org/I4210157890']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006462098', 'display_name': 'Ofelia F. Alonso', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145608581', 'display_name': 'University of Miami', 'ror': 'https://ror.org/02dgjyy92', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145608581']}, {'id': 'https://openalex.org/I4210157890', 'display_name': 'Neurological Surgery', 'ror': 'https://ror.org/04r0gp612', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210157890']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ofelia F Alonso', 'raw_affiliation_strings': ['Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA', 'Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA', 'institution_ids': ['https://openalex.org/I145608581', 'https://openalex.org/I4210157890']}, {'raw_affiliation_string': 'Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA', 'institution_ids': ['https://openalex.org/I145608581', 'https://openalex.org/I4210157890']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057601283', 'display_name': 'Helen M. Bramlett', 'orcid': 'https://orcid.org/0000-0002-8200-0973'}, 'institutions': [{'id': 'https://openalex.org/I145608581', 'display_name': 'University of Miami', 'ror': 'https://ror.org/02dgjyy92', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145608581']}, {'id': 'https://openalex.org/I4210157890', 'display_name': 'Neurological Surgery', 'ror': 'https://ror.org/04r0gp612', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210157890']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Helen M Bramlett', 'raw_affiliation_strings': ['Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA', 'Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA', 'institution_ids': ['https://openalex.org/I145608581', 'https://openalex.org/I4210157890']}, {'raw_affiliation_string': 'Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA', 'institution_ids': ['https://openalex.org/I145608581', 'https://openalex.org/I4210157890']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011373172', 'display_name': 'W. Dalton Dietrich', 'orcid': 'https://orcid.org/0000-0002-8732-4942'}, 'institutions': [{'id': 'https://openalex.org/I4210157890', 'display_name': 'Neurological Surgery', 'ror': 'https://ror.org/04r0gp612', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210157890']}, {'id': 'https://openalex.org/I145608581', 'display_name': 'University of Miami', 'ror': 'https://ror.org/02dgjyy92', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145608581']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'W Dalton Dietrich', 'raw_affiliation_strings': ['Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA', 'Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA', 'institution_ids': ['https://openalex.org/I4210157890', 'https://openalex.org/I145608581']}, {'raw_affiliation_string': 'Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA', 'institution_ids': ['https://openalex.org/I145608581', 'https://openalex.org/I4210157890']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5045688399', 'display_name': 'Robert W. Keane', 'orcid': 'https://orcid.org/0000-0003-4068-9511'}, 'institutions': [{'id': 'https://openalex.org/I145608581', 'display_name': 'University of Miami', 'ror': 'https://ror.org/02dgjyy92', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145608581']}, {'id': 'https://openalex.org/I4210157890', 'display_name': 'Neurological Surgery', 'ror': 'https://ror.org/04r0gp612', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210157890']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Robert W Keane', 'raw_affiliation_strings': ['Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA', 'Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA', 'institution_ids': ['https://openalex.org/I145608581', 'https://openalex.org/I4210157890']}, {'raw_affiliation_string': 'Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida, USA', 'institution_ids': ['https://openalex.org/I145608581']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5045688399'], 'corresponding_institution_ids': ['https://openalex.org/I145608581', 'https://openalex.org/I4210157890'], 'apc_list': None, 'apc_paid': None, 'fwci': 3.986, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 290, 'citation_normalized_percentile': {'value': 0.999984, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '29', 'issue': '7', 'first_page': '1251', 'last_page': '1261'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11078', 'display_name': 'Inflammasome and immune disorders', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11078', 'display_name': 'Inflammasome and immune disorders', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11848', 'display_name': 'Heme Oxygenase-1 and Carbon Monoxide', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11456', 'display_name': 'Neuroscience of respiration and sleep', 'score': 0.9766, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pyrin-domain', 'display_name': 'Pyrin domain', 'score': 0.73004466}, {'id': 'https://openalex.org/keywords/nlrp1', 'display_name': 'NLRP1', 'score': 0.64286745}, {'id': 'https://openalex.org/keywords/proinflammatory-cytokine', 'display_name': 'Proinflammatory cytokine', 'score': 0.58502173}, {'id': 'https://openalex.org/keywords/interleukin-18', 'display_name': 'Interleukin 18', 'score': 0.43006366}], 'concepts': [{'id': 'https://openalex.org/C2777209026', 'wikidata': 'https://www.wikidata.org/wiki/Q412405', 'display_name': 'Inflammasome', 'level': 3, 'score': 0.93714607}, {'id': 'https://openalex.org/C136449434', 'wikidata': 'https://www.wikidata.org/wiki/Q428253', 'display_name': 'Innate immune system', 'level': 3, 'score': 0.756444}, {'id': 'https://openalex.org/C139174496', 'wikidata': 'https://www.wikidata.org/wiki/Q24725912', 'display_name': 'Pyrin domain', 'level': 4, 'score': 0.73004466}, {'id': 'https://openalex.org/C176912530', 'wikidata': 'https://www.wikidata.org/wiki/Q18036542', 'display_name': 'NLRP1', 'level': 5, 'score': 0.64286745}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.600968}, {'id': 'https://openalex.org/C139964883', 'wikidata': 'https://www.wikidata.org/wiki/Q14901964', 'display_name': 'Caspase 1', 'level': 4, 'score': 0.5931346}, {'id': 'https://openalex.org/C164027704', 'wikidata': 'https://www.wikidata.org/wiki/Q3491837', 'display_name': 'Proinflammatory cytokine', 'level': 3, 'score': 0.58502173}, {'id': 'https://openalex.org/C2781017439', 'wikidata': 'https://www.wikidata.org/wiki/Q1995526', 'display_name': 'Traumatic brain injury', 'level': 2, 'score': 0.5243248}, {'id': 'https://openalex.org/C98424977', 'wikidata': 'https://www.wikidata.org/wiki/Q25805', 'display_name': 'Caspase', 'level': 4, 'score': 0.5109133}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.4692419}, {'id': 'https://openalex.org/C68239362', 'wikidata': 'https://www.wikidata.org/wiki/Q14907187', 'display_name': 'Interleukin 18', 'level': 3, 'score': 0.43006366}, {'id': 'https://openalex.org/C87753298', 'wikidata': 'https://www.wikidata.org/wiki/Q17157137', 'display_name': 'Neuroinflammation', 'level': 3, 'score': 0.42921162}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39953455}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.38661623}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.37979794}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.37075567}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.24214613}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.15117118}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.081840724}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001930', 'descriptor_name': 'Brain Injuries', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D046912', 'descriptor_name': 'Multiprotein Complexes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001930', 'descriptor_name': 'Brain Injuries', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020170', 'descriptor_name': 'Caspase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020170', 'descriptor_name': 'Caspase 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000939', 'descriptor_name': 'Epitopes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053583', 'descriptor_name': 'Interleukin-1beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046912', 'descriptor_name': 'Multiprotein Complexes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/jcbfm.2009.46', 'pdf_url': 'https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2009.46', 'source': {'id': 'https://openalex.org/S89339265', 'display_name': 'Journal of Cerebral Blood Flow & Metabolism', 'issn_l': '0271-678X', 'issn': ['0271-678X', '1559-7016'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2846547', 'pdf_url': 'https://europepmc.org/articles/pmc2846547?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846547', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19401709', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/jcbfm.2009.46', 'pdf_url': 'https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2009.46', 'source': {'id': 'https://openalex.org/S89339265', 'display_name': 'Journal of Cerebral Blood Flow & Metabolism', 'issn_l': '0271-678X', 'issn': ['0271-678X', '1559-7016'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.86}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W111104', 'https://openalex.org/W1529674879', 'https://openalex.org/W1589710900', 'https://openalex.org/W1677247022', 'https://openalex.org/W1738825', 'https://openalex.org/W1885912605', 'https://openalex.org/W1964406898', 'https://openalex.org/W1964574311', 'https://openalex.org/W1964919653', 'https://openalex.org/W1967436988', 'https://openalex.org/W1969993314', 'https://openalex.org/W1978525572', 'https://openalex.org/W1981724301', 'https://openalex.org/W1983615367', 'https://openalex.org/W1984026160', 'https://openalex.org/W1986731647', 'https://openalex.org/W2015205701', 'https://openalex.org/W2031413466', 'https://openalex.org/W2038009009', 'https://openalex.org/W2042590551', 'https://openalex.org/W2042961233', 'https://openalex.org/W2043091577', 'https://openalex.org/W2044326611', 'https://openalex.org/W2046440869', 'https://openalex.org/W2065403797', 'https://openalex.org/W2065949360', 'https://openalex.org/W2067051297', 'https://openalex.org/W2067097932', 'https://openalex.org/W2071002396', 'https://openalex.org/W2071682354', 'https://openalex.org/W2083119828', 'https://openalex.org/W2088164523', 'https://openalex.org/W2100379211', 'https://openalex.org/W2102694854', 'https://openalex.org/W2121369239', 'https://openalex.org/W2121560754', 'https://openalex.org/W2162295519', 'https://openalex.org/W2166452818', 'https://openalex.org/W2170382285', 'https://openalex.org/W4237524633', 'https://openalex.org/W4240713772', 'https://openalex.org/W4322697531', 'https://openalex.org/W4364863534'], 'related_works': ['https://openalex.org/W4248878742', 'https://openalex.org/W3157207769', 'https://openalex.org/W2558550413', 'https://openalex.org/W2554685263', 'https://openalex.org/W2291436232', 'https://openalex.org/W2038979563', 'https://openalex.org/W2026209203', 'https://openalex.org/W2018541689', 'https://openalex.org/W2008631375', 'https://openalex.org/W1739883462'], 'abstract_inverted_index': {'Traumatic': [0], 'brain': [1, 11, 161, 177], 'injury': [2, 84, 115, 162], 'elicits': [3], 'acute': [4], 'inflammation': [5], 'that': [6, 38, 143], 'in': [7, 19, 75, 133, 137], 'turn': [8], 'exacerbates': [9], 'primary': [10], 'damage.': [12], 'A': [13], 'crucial': [14], 'part': [15], 'of': [16, 28, 51, 67, 77, 88, 91, 94, 97, 103, 124, 130, 151, 175], 'innate': [17, 153], 'immunity': [18], 'the': [20, 39, 64, 78, 104, 144, 152, 172], 'immune': [21], 'privileged': [22], 'central': [23, 154], 'nervous': [24, 155], 'system': [25, 156], 'involves': [26], 'production': [27], 'proinflammatory': [29], 'cytokines': [30], 'mediated': [31], 'by': [32], 'inflammasome': [33, 49, 106, 146], 'signaling.': [34], 'Here,': [35], 'we': [36], 'show': [37, 142], 'nucleotide-binding,': [40], 'leucine-rich': [41], 'repeat': [42], 'pyrin': [43], 'domain': [44, 62], 'containing': [45, 58], 'protein': [46, 57, 126], '1': [47, 72], '(NLRP1)': [48], 'consisting': [50], 'NLRP1,': [52], 'caspase-1,': [53, 92], 'caspase-11,': [54], 'apoptosis-associated': [55], 'speck-like': [56], 'a': [59, 134, 166], 'caspase': [60], 'recruitment': [61], '(ASC),': [63], 'X-linked': [65, 95, 122], 'inhibitor': [66, 96, 123], 'apoptosis': [68, 98, 125], 'protein,': [69, 99], 'and': [70, 100, 128, 163], 'pannexin': [71], 'is': [73], 'expressed': [74], 'neurons': [76], 'cerebral': [79], 'cortex.': [80], 'Moderate': [81], 'parasagittal': [82], 'fluid-percussion': [83, 114], '(FPI)': [85], 'induced': [86], 'processing': [87, 129], 'interleukin-1β,': [89, 131], 'activation': [90], 'cleavage': [93], 'promoted': [101], 'assembly': [102], 'NLRP1': [105, 145], 'complex.': [107], 'Anti-ASC': [108], 'neutralizing': [109], 'antibodies': [110], 'administered': [111], 'immediately': [112], 'after': [113, 159], 'to': [116], 'injured': [117], 'rats': [118], 'reduced': [119], 'caspase-1': [120], 'activation,': [121], 'cleavage,': [127], 'resulting': [132], 'significant': [135], 'decrease': [136], 'contusion': [138], 'volume.': [139], 'These': [140], 'studies': [141], 'constitutes': [147], 'an': [148], 'important': [149], 'component': [150], 'inflammatory': [157], 'response': [158], 'traumatic': [160], 'may': [164], 'be': [165], 'novel': [167], 'therapeutic': [168], 'target': [169], 'for': [170], 'reducing': [171], 'damaging': [173], 'effects': [174], 'posttraumatic': [176], 'inflammation.': [178]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2012789061', 'counts_by_year': [{'year': 2024, 'cited_by_count': 17}, {'year': 2023, 'cited_by_count': 17}, {'year': 2022, 'cited_by_count': 27}, {'year': 2021, 'cited_by_count': 18}, {'year': 2020, 'cited_by_count': 27}, {'year': 2019, 'cited_by_count': 17}, {'year': 2018, 'cited_by_count': 24}, {'year': 2017, 'cited_by_count': 21}, {'year': 2016, 'cited_by_count': 18}, {'year': 2015, 'cited_by_count': 26}, {'year': 2014, 'cited_by_count': 27}, {'year': 2013, 'cited_by_count': 21}, {'year': 2012, 'cited_by_count': 14}], 'updated_date': '2024-12-20T23:04:14.933247', 'created_date': '2016-06-24'}