Publication Information

{'id': 'https://openalex.org/W2012708129', 'doi': 'https://doi.org/10.1038/bjc.2012.153', 'title': 'Regorafenib (BAY 73-4506) in advanced colorectal cancer: a phase I study', 'display_name': 'Regorafenib (BAY 73-4506) in advanced colorectal cancer: a phase I study', 'publication_year': 2012, 'publication_date': '2012-05-01', 'ids': {'openalex': 'https://openalex.org/W2012708129', 'doi': 'https://doi.org/10.1038/bjc.2012.153', 'mag': '2012708129', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22568966', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3364125'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/bjc.2012.153', 'pdf_url': 'https://www.nature.com/articles/bjc2012153.pdf', 'source': {'id': 'https://openalex.org/S62966998', 'display_name': 'British Journal of Cancer', 'issn_l': '0007-0920', 'issn': ['0007-0920', '1532-1827'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.nature.com/articles/bjc2012153.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5018436714', 'display_name': 'Dirk Strumberg', 'orcid': 'https://orcid.org/0000-0001-7053-8365'}, 'institutions': [{'id': 'https://openalex.org/I904495901', 'display_name': 'Ruhr University Bochum', 'ror': 'https://ror.org/04tsk2644', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I904495901']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'D Strumberg', 'raw_affiliation_strings': ['Department of Hematology and Medical Oncology, University of Bochum, Marienhospital Herne, Hölkeskampring 40, D-44625 Herne, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology and Medical Oncology, University of Bochum, Marienhospital Herne, Hölkeskampring 40, D-44625 Herne, Germany.', 'institution_ids': ['https://openalex.org/I904495901']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107233200', 'display_name': 'M. E. Scheulen', 'orcid': None}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'M E Scheulen', 'raw_affiliation_strings': ['West German Cancer Center, Essen, Germany'], 'affiliations': [{'raw_affiliation_string': 'West German Cancer Center, Essen, Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040836871', 'display_name': 'Beate Schultheis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I904495901', 'display_name': 'Ruhr University Bochum', 'ror': 'https://ror.org/04tsk2644', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I904495901']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'B Schultheis', 'raw_affiliation_strings': ['Department of Hematology and Medical Oncology, University of Bochum (Marienhospital Herne), Herne, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology and Medical Oncology, University of Bochum (Marienhospital Herne), Herne, Germany', 'institution_ids': ['https://openalex.org/I904495901']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045084441', 'display_name': 'Heike Richly', 'orcid': None}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'H Richly', 'raw_affiliation_strings': ['West German Cancer Center, Essen, Germany'], 'affiliations': [{'raw_affiliation_string': 'West German Cancer Center, Essen, Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067135726', 'display_name': 'Annette Frost', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161046081', 'display_name': 'University of Freiburg', 'ror': 'https://ror.org/0245cg223', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I161046081']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'A Frost', 'raw_affiliation_strings': ['Tumor Biology Center, Albert Ludwigs University Freiburg, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Tumor Biology Center, Albert Ludwigs University Freiburg, Germany.', 'institution_ids': ['https://openalex.org/I161046081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109229953', 'display_name': 'Martin Büchert', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801240073', 'display_name': 'University Medical Center Freiburg', 'ror': 'https://ror.org/03vzbgh69', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801240073']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'M Büchert', 'raw_affiliation_strings': ['Magnetic Resonance Development and Application Center, University Medical Center, Freiburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Magnetic Resonance Development and Application Center, University Medical Center, Freiburg, Germany', 'institution_ids': ['https://openalex.org/I2801240073']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111696351', 'display_name': 'O. Christensen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I150569930', 'display_name': 'Bayer (United States)', 'ror': 'https://ror.org/034ffbg36', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I150569930', 'https://openalex.org/I67348948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'O Christensen', 'raw_affiliation_strings': ['Bayer HealthCare Pharmaceuticals, Montville, USA.'], 'affiliations': [{'raw_affiliation_string': 'Bayer HealthCare Pharmaceuticals, Montville, USA.', 'institution_ids': ['https://openalex.org/I150569930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109722483', 'display_name': 'Michael Jeffers', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I150569930', 'display_name': 'Bayer (United States)', 'ror': 'https://ror.org/034ffbg36', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I150569930', 'https://openalex.org/I67348948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M Jeffers', 'raw_affiliation_strings': ['Bayer HealthCare Pharmaceuticals, Montville, USA.'], 'affiliations': [{'raw_affiliation_string': 'Bayer HealthCare Pharmaceuticals, Montville, USA.', 'institution_ids': ['https://openalex.org/I150569930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059259953', 'display_name': 'Roland Heinig', 'orcid': 'https://orcid.org/0000-0002-4645-5428'}, 'institutions': [{'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'R Heinig', 'raw_affiliation_strings': [' Bayer Pharma AG, Wuppertal, Germany'], 'affiliations': [{'raw_affiliation_string': ' Bayer Pharma AG, Wuppertal, Germany', 'institution_ids': ['https://openalex.org/I67348948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059144177', 'display_name': 'Oliver Boix', 'orcid': 'https://orcid.org/0000-0003-3704-0877'}, 'institutions': [{'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'O Boix', 'raw_affiliation_strings': [' Bayer Pharma AG, Wuppertal, Germany'], 'affiliations': [{'raw_affiliation_string': ' Bayer Pharma AG, Wuppertal, Germany', 'institution_ids': ['https://openalex.org/I67348948']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112408355', 'display_name': 'K. Mross', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161046081', 'display_name': 'University of Freiburg', 'ror': 'https://ror.org/0245cg223', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I161046081']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'K Mross', 'raw_affiliation_strings': ['Tumor Biology Center, Albert Ludwigs University Freiburg, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Tumor Biology Center, Albert Ludwigs University Freiburg, Germany.', 'institution_ids': ['https://openalex.org/I161046081']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3790, 'currency': 'EUR', 'value_usd': 4690, 'provenance': 'doaj'}, 'apc_paid': {'value': 3790, 'currency': 'EUR', 'value_usd': 4690, 'provenance': 'doaj'}, 'fwci': 14.387, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 236, 'citation_normalized_percentile': {'value': 0.999951, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '106', 'issue': '11', 'first_page': '1722', 'last_page': '1727'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11067', 'display_name': 'Colorectal Cancer Treatments and Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11067', 'display_name': 'Colorectal Cancer Treatments and Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11752', 'display_name': 'Cancer Treatment and Pharmacology', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10073', 'display_name': 'Hepatocellular Carcinoma Treatment and Prognosis', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/regorafenib', 'display_name': 'Regorafenib', 'score': 0.9725163}, {'id': 'https://openalex.org/keywords/tolerability', 'display_name': 'Tolerability', 'score': 0.862278}, {'id': 'https://openalex.org/keywords/pharmacodynamics', 'display_name': 'Pharmacodynamics', 'score': 0.44865602}], 'concepts': [{'id': 'https://openalex.org/C2776248978', 'wikidata': 'https://www.wikidata.org/wiki/Q3891664', 'display_name': 'Regorafenib', 'level': 4, 'score': 0.9725163}, {'id': 'https://openalex.org/C2778375690', 'wikidata': 'https://www.wikidata.org/wiki/Q7814214', 'display_name': 'Tolerability', 'level': 3, 'score': 0.862278}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.84874177}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.6099036}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.57011354}, {'id': 'https://openalex.org/C2778570526', 'wikidata': 'https://www.wikidata.org/wiki/Q653197', 'display_name': 'Rash', 'level': 2, 'score': 0.55099314}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.48030657}, {'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.46530515}, {'id': 'https://openalex.org/C72563966', 'wikidata': 'https://www.wikidata.org/wiki/Q1303415', 'display_name': 'Cohort', 'level': 2, 'score': 0.45514822}, {'id': 'https://openalex.org/C111113717', 'wikidata': 'https://www.wikidata.org/wiki/Q725307', 'display_name': 'Pharmacodynamics', 'level': 3, 'score': 0.44865602}, {'id': 'https://openalex.org/C31760486', 'wikidata': 'https://www.wikidata.org/wiki/Q7180990', 'display_name': 'Phases of clinical research', 'level': 3, 'score': 0.42270663}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.35362828}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.34642774}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.3364901}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.2916109}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.287925}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.28091985}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.09538275}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D010671', 'descriptor_name': 'Phenylurea Compounds', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018572', 'descriptor_name': 'Disease-Free Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053208', 'descriptor_name': 'Kaplan-Meier Estimate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/bjc.2012.153', 'pdf_url': 'https://www.nature.com/articles/bjc2012153.pdf', 'source': {'id': 'https://openalex.org/S62966998', 'display_name': 'British Journal of Cancer', 'issn_l': '0007-0920', 'issn': ['0007-0920', '1532-1827'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3364125', 'pdf_url': 'https://europepmc.org/articles/pmc3364125?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364125', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22568966', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/bjc.2012.153', 'pdf_url': 'https://www.nature.com/articles/bjc2012153.pdf', 'source': {'id': 'https://openalex.org/S62966998', 'display_name': 'British Journal of Cancer', 'issn_l': '0007-0920', 'issn': ['0007-0920', '1532-1827'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.86, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 21, 'referenced_works': ['https://openalex.org/W1581590112', 'https://openalex.org/W1879099940', 'https://openalex.org/W1968209756', 'https://openalex.org/W1987053006', 'https://openalex.org/W2019607817', 'https://openalex.org/W2020830322', 'https://openalex.org/W2065018855', 'https://openalex.org/W2081071240', 'https://openalex.org/W2097121246', 'https://openalex.org/W2106787323', 'https://openalex.org/W2117753040', 'https://openalex.org/W2125763124', 'https://openalex.org/W2140510616', 'https://openalex.org/W2141639829', 'https://openalex.org/W2156461482', 'https://openalex.org/W2157769714', 'https://openalex.org/W2318805173', 'https://openalex.org/W2403353509', 'https://openalex.org/W244746785', 'https://openalex.org/W2616059838', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W4380224996', 'https://openalex.org/W4379282845', 'https://openalex.org/W4379282287', 'https://openalex.org/W4319741957', 'https://openalex.org/W4293577346', 'https://openalex.org/W3025933834', 'https://openalex.org/W2811168026', 'https://openalex.org/W2624771607', 'https://openalex.org/W2319024198', 'https://openalex.org/W2314601331'], 'abstract_inverted_index': {'In': [0], 'a': [1], 'phase': [2, 170], 'I': [3, 171], 'dose-escalation': [4, 78], 'study,': [5], 'regorafenib': [6, 32, 85, 139, 181], 'demonstrated': [7], 'tolerability': [8, 159], 'and': [9, 58, 79, 110, 122, 140, 160], 'antitumour': [10, 161], 'activity': [11, 162], 'in': [12, 39, 43, 76, 154, 163, 182], 'solid': [13], 'tumour': [14, 152], 'patients.': [15, 156], 'The': [16, 98], 'study': [17, 172], 'was': [18, 92, 130], 'expanded': [19], 'to': [20], 'focus': [21], 'on': [22], 'patients': [23, 61, 83, 113, 164], 'with': [24, 62, 165], 'metastatic': [25, 166], 'colorectal': [26], 'cancer': [27], '(CRC).': [28], 'Patients': [29], 'received': [30, 84], 'oral': [31], '60–220': [33], 'mg': [34, 37, 87], 'daily': [35, 38], '(160': [36], 'the': [40, 77, 174], 'extension': [41, 80], 'cohort)': [42], 'cycles': [44], 'of': [45, 70, 180], '21': [46], 'days': [47, 50, 94, 132], 'on,': [48], '7': [49], 'off': [51], 'treatment.': [52], 'Assessments': [53], 'included': [54, 103], 'toxicity,': [55], 'response,': [56], 'pharmacokinetics': [57], 'pharmacodynamics.': [59], 'Thirty-eight': [60], 'heavily': [63], 'pretreated': [64], 'CRC': [65], '(median': [66], '4': [67], 'prior': [68], 'lines': [69], 'therapy,': [71], 'range': [72], '0–7)': [73], 'were': [74, 114], 'enrolled': [75], 'phases;': [81], '26': [82], '160': [86], 'daily.': [88], 'Median': [89, 127], 'treatment': [90], 'duration': [91], '53': [93], '(range': [95], '7–280': [96], 'days).': [97], 'most': [99, 155], 'common': [100], 'treatment-related': [101], 'toxicities': [102], 'hand–foot': [104], 'skin': [105], 'reaction,': [106], 'fatigue,': [107], 'voice': [108], 'change': [109], 'rash.': [111], 'Twenty-seven': [112], 'evaluable': [115], 'for': [116, 176], 'response:': [117], '1': [118], 'achieved': [119], 'partial': [120], 'response': [121], '19': [123], 'had': [124, 144], 'stable': [125], 'disease.': [126], 'progression-free': [128], 'survival': [129], '107': [131], '(95%': [133], 'CI,': [134], '66–161).': [135], 'At': [136], 'steady': [137], 'state,': [138], 'its': [141], 'active': [142], 'metabolites': [143], 'similar': [145], 'systemic': [146], 'exposure.': [147], 'Pharmacodynamic': [148], 'assessment': [149], 'indicated': [150], 'decreased': [151], 'perfusion': [153], 'Regorafenib': [157], 'showed': [158], 'CRC.': [167], 'This': [168], 'expanded-cohort': [169], 'provided': [173], 'foundation': [175], 'further': [177], 'clinical': [178], 'trials': [179], 'this': [183], 'patient': [184], 'population.': [185]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2012708129', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 15}, {'year': 2021, 'cited_by_count': 18}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 17}, {'year': 2018, 'cited_by_count': 16}, {'year': 2017, 'cited_by_count': 26}, {'year': 2016, 'cited_by_count': 26}, {'year': 2015, 'cited_by_count': 27}, {'year': 2014, 'cited_by_count': 29}, {'year': 2013, 'cited_by_count': 26}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-09T01:55:11.454854', 'created_date': '2016-06-24'}