Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2012695707', 'doi': 'https://doi.org/10.1055/s-0033-1347236', 'title': 'Bioequivalence of Two Lansoprazole Delayed Release Capsules 30 mg in Healthy Male Volunteers under Fasting, Fed and Fasting-applesauce conditions: A Partial Replicate Crossover Study Design to Estimate the Pharmacokinetics of Highly Variable Drugs', 'display_name': 'Bioequivalence of Two Lansoprazole Delayed Release Capsules 30 mg in Healthy Male Volunteers under Fasting, Fed and Fasting-applesauce conditions: A Partial Replicate Crossover Study Design to Estimate the Pharmacokinetics of Highly Variable Drugs', 'publication_year': 2013, 'publication_date': '2013-06-18', 'ids': {'openalex': 'https://openalex.org/W2012695707', 'doi': 'https://doi.org/10.1055/s-0033-1347236', 'mag': '2012695707', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23780504'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1055/s-0033-1347236', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210226141', 'display_name': 'Drug Research', 'issn_l': '2194-9379', 'issn': ['2194-9379', '2194-9387'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320000', 'host_organization_name': 'Thieme Medical Publishers (Germany)', 'host_organization_lineage': ['https://openalex.org/P4310320000'], 'host_organization_lineage_names': ['Thieme Medical Publishers (Germany)'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5078000004', 'display_name': 'Satyanarayana Thota', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117495', 'display_name': "Dr. Reddy's Laboratories (India)", 'ror': 'https://ror.org/01rkxa860', 'country_code': 'IN', 'type': 'company', 'lineage': ['https://openalex.org/I4210117495']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'S. Thota', 'raw_affiliation_strings': ['Clinical Pharmacology and Pharmacokinetics, Integrated Product Development, Dr.Reddy’s Laboratories Limited, Hyderabad, India'], 'affiliations': [{'raw_affiliation_string': 'Clinical Pharmacology and Pharmacokinetics, Integrated Product Development, Dr.Reddy’s Laboratories Limited, Hyderabad, India', 'institution_ids': ['https://openalex.org/I4210117495']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051860282', 'display_name': 'Shabana I. Khan', 'orcid': 'https://orcid.org/0000-0001-6429-7219'}, 'institutions': [{'id': 'https://openalex.org/I4210117495', 'display_name': "Dr. Reddy's Laboratories (India)", 'ror': 'https://ror.org/01rkxa860', 'country_code': 'IN', 'type': 'company', 'lineage': ['https://openalex.org/I4210117495']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'S. Khan', 'raw_affiliation_strings': ['Clinical Pharmacology and Pharmacokinetics, Integrated Product Development, Dr.Reddy’s Laboratories Limited, Hyderabad, India'], 'affiliations': [{'raw_affiliation_string': 'Clinical Pharmacology and Pharmacokinetics, Integrated Product Development, Dr.Reddy’s Laboratories Limited, Hyderabad, India', 'institution_ids': ['https://openalex.org/I4210117495']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058050527', 'display_name': 'Sudhakar Koundinya Tippabhotla', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117495', 'display_name': "Dr. Reddy's Laboratories (India)", 'ror': 'https://ror.org/01rkxa860', 'country_code': 'IN', 'type': 'company', 'lineage': ['https://openalex.org/I4210117495']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'S. Tippabhotla', 'raw_affiliation_strings': ['Clinical Pharmacology and Pharmacokinetics, Integrated Product Development, Dr.Reddy’s Laboratories Limited, Hyderabad, India'], 'affiliations': [{'raw_affiliation_string': 'Clinical Pharmacology and Pharmacokinetics, Integrated Product Development, Dr.Reddy’s Laboratories Limited, Hyderabad, India', 'institution_ids': ['https://openalex.org/I4210117495']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066462313', 'display_name': 'Ramakrishna Battula', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117495', 'display_name': "Dr. Reddy's Laboratories (India)", 'ror': 'https://ror.org/01rkxa860', 'country_code': 'IN', 'type': 'company', 'lineage': ['https://openalex.org/I4210117495']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'R. Battula', 'raw_affiliation_strings': ['Clinical Pharmacology and Pharmacokinetics, Integrated Product Development, Dr.Reddy’s Laboratories Limited, Hyderabad, India'], 'affiliations': [{'raw_affiliation_string': 'Clinical Pharmacology and Pharmacokinetics, Integrated Product Development, Dr.Reddy’s Laboratories Limited, Hyderabad, India', 'institution_ids': ['https://openalex.org/I4210117495']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020804570', 'display_name': 'Chaitanya Gadiko', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117495', 'display_name': "Dr. Reddy's Laboratories (India)", 'ror': 'https://ror.org/01rkxa860', 'country_code': 'IN', 'type': 'company', 'lineage': ['https://openalex.org/I4210117495']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'C. Gadiko', 'raw_affiliation_strings': ['Clinical Pharmacology and Pharmacokinetics, Integrated Product Development, Dr.Reddy’s Laboratories Limited, Hyderabad, India'], 'affiliations': [{'raw_affiliation_string': 'Clinical Pharmacology and Pharmacokinetics, Integrated Product Development, Dr.Reddy’s Laboratories Limited, Hyderabad, India', 'institution_ids': ['https://openalex.org/I4210117495']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5017473916', 'display_name': 'Vobalaboina Venkateswarlu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117495', 'display_name': "Dr. Reddy's Laboratories (India)", 'ror': 'https://ror.org/01rkxa860', 'country_code': 'IN', 'type': 'company', 'lineage': ['https://openalex.org/I4210117495']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'V. Vobalaboina', 'raw_affiliation_strings': ['Clinical Pharmacology and Pharmacokinetics, Integrated Product Development, Dr.Reddy’s Laboratories Limited, Hyderabad, India'], 'affiliations': [{'raw_affiliation_string': 'Clinical Pharmacology and Pharmacokinetics, Integrated Product Development, Dr.Reddy’s Laboratories Limited, Hyderabad, India', 'institution_ids': ['https://openalex.org/I4210117495']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.723478, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 76, 'max': 78}, 'biblio': {'volume': '63', 'issue': '11', 'first_page': '551', 'last_page': '557'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.9903, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.9903, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11460', 'display_name': 'Analytical Methods in Pharmaceuticals', 'score': 0.9901, 'subfield': {'id': 'https://openalex.org/subfields/1602', 'display_name': 'Analytical Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10365', 'display_name': 'Gastrointestinal motility and disorders', 'score': 0.973, 'subfield': {'id': 'https://openalex.org/subfields/2715', 'display_name': 'Gastroenterology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bioequivalence', 'display_name': 'Bioequivalence', 'score': 0.98148036}, {'id': 'https://openalex.org/keywords/crossover-study', 'display_name': 'Crossover study', 'score': 0.7942736}, {'id': 'https://openalex.org/keywords/replicate', 'display_name': 'Replicate', 'score': 0.4263055}], 'concepts': [{'id': 'https://openalex.org/C42404028', 'wikidata': 'https://www.wikidata.org/wiki/Q864940', 'display_name': 'Bioequivalence', 'level': 3, 'score': 0.98148036}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.79606485}, {'id': 'https://openalex.org/C87813604', 'wikidata': 'https://www.wikidata.org/wiki/Q1242899', 'display_name': 'Crossover study', 'level': 4, 'score': 0.7942736}, {'id': 'https://openalex.org/C44249647', 'wikidata': 'https://www.wikidata.org/wiki/Q208498', 'display_name': 'Confidence interval', 'level': 2, 'score': 0.63521314}, {'id': 'https://openalex.org/C122048520', 'wikidata': 'https://www.wikidata.org/wiki/Q2913954', 'display_name': 'Percentile', 'level': 2, 'score': 0.4496291}, {'id': 'https://openalex.org/C2781162219', 'wikidata': 'https://www.wikidata.org/wiki/Q26250693', 'display_name': 'Replicate', 'level': 2, 'score': 0.4263055}, {'id': 'https://openalex.org/C22979827', 'wikidata': 'https://www.wikidata.org/wiki/Q5137311', 'display_name': 'Cmax', 'level': 3, 'score': 0.41426766}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3543109}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.33642516}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.30779228}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.29148895}, {'id': 'https://openalex.org/C33923547', 'wikidata': 'https://www.wikidata.org/wiki/Q395', 'display_name': 'Mathematics', 'level': 0, 'score': 0.1835882}, {'id': 'https://openalex.org/C105795698', 'wikidata': 'https://www.wikidata.org/wiki/Q12483', 'display_name': 'Statistics', 'level': 1, 'score': 0.11385152}, {'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.09321311}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D064747', 'descriptor_name': 'Lansoprazole', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D054328', 'descriptor_name': 'Proton Pump Inhibitors', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002214', 'descriptor_name': 'Capsules', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018592', 'descriptor_name': 'Cross-Over Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003692', 'descriptor_name': 'Delayed-Action Preparations', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004435', 'descriptor_name': 'Eating', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005215', 'descriptor_name': 'Fasting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064747', 'descriptor_name': 'Lansoprazole', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064747', 'descriptor_name': 'Lansoprazole', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054328', 'descriptor_name': 'Proton Pump Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054328', 'descriptor_name': 'Proton Pump Inhibitors', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D013810', 'descriptor_name': 'Therapeutic Equivalency', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1055/s-0033-1347236', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210226141', 'display_name': 'Drug Research', 'issn_l': '2194-9379', 'issn': ['2194-9379', '2194-9387'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320000', 'host_organization_name': 'Thieme Medical Publishers (Germany)', 'host_organization_lineage': ['https://openalex.org/P4310320000'], 'host_organization_lineage_names': ['Thieme Medical Publishers (Germany)'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23780504', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.65}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4296918699', 'https://openalex.org/W2950351041', 'https://openalex.org/W2914400490', 'https://openalex.org/W2787516851', 'https://openalex.org/W2431224659', 'https://openalex.org/W2187179074', 'https://openalex.org/W2087796686', 'https://openalex.org/W2082887863', 'https://openalex.org/W151882183', 'https://openalex.org/W124377181'], 'abstract_inverted_index': {'An': [0], 'open-label,': [1], '2-treatment,': [2], '3-sequence,': [3], '3-period,': [4], 'single-dose,': [5], 'partial': [6], 'replicate': [7], 'crossover': [8, 63], 'studies': [9, 132], 'under': [10], 'fasting': [11, 129], '(<i>n</i>=48),': [12], 'fed': [13, 131], '(<i>n</i>=60)': [14], 'and': [15, 103, 109, 130, 149, 161, 194], 'fasting-applesauce': [16, 175], '(<i>n</i>=48)': [17], '(sprinkled': [18], 'on': [19, 113, 121, 204], 'one': [20], 'table': [21], 'spoonful': [22], 'of': [23, 39, 70, 105, 124, 188, 191], 'applesauce)': [24], 'modalities': [25], 'were': [26, 59, 77, 167, 196], 'conducted': [27], 'in': [28, 61], 'healthy': [29], 'adult': [30], 'male': [31], 'volunteers': [32], 'to': [33, 82, 218], 'evaluate': [34], 'bioequivalence': [35, 117, 135, 179], 'between': [36], '2': [37], 'formulations': [38, 58], 'lansoprazole': [40, 84], 'delayed': [41], 'release': [42], 'capsules': [43], '30': [44], 'mg.': [45], 'In': [46, 128, 174], 'all': [47], 'the': [48, 95, 125, 144, 151, 162, 169, 185, 198, 213], '3': [49], 'studies,': [50], 'as': [51], 'per': [52], 'randomization,': [53], 'either': [54], 'test': [55, 214], 'or': [56], 'reference': [57, 126, 219], 'administered': [60], 'a': [62, 66, 88], 'manner': [64], 'with': [65, 138, 182], 'required': [67], 'washout': [68], 'period': [69], 'at': [71], 'least': [72], '7': [73], 'days.': [74], 'Blood': [75], 'samples': [76], 'collected': [78], 'adequately': [79], '(0–24': [80], 'h)': [81], 'determine': [83], 'plasma': [85], 'concentrations': [86], 'using': [87], 'validated': [89], 'LC-MS/MS': [90], 'analytical': [91], 'method.': [92], 'To': [93], 'characterize': [94], 'pharmacokinetic': [96, 145], 'parameters': [97, 146], '(C<sub>max</sub>,': [98], 'AUC<sub>0–t</sub>,': [99], 'AUC<sub>0–∞</sub>,': [100, 150], 'T<sub>max</sub>,': [101], 'K<sub>el</sub>': [102], 'T<sub>1/2</sub>)': [104], 'lansoprazole,': [106], 'non-compartmental': [107], 'analysis': [108], 'ANOVA': [110], 'was': [111, 118, 136, 159, 180, 210], 'applied': [112], 'ln-transformed': [114, 189], 'values.': [115], 'The': [116], 'tested': [119], 'based': [120], 'within-subject': [122], 'variability': [123], 'formulation.': [127, 220], '(within-subject': [133, 177], 'variability>30%)': [134], 'evaluated': [137, 181], 'scaled': [139], 'average': [140, 183], 'bioequivalence,': [141, 184], 'hence': [142], 'for': [143, 156], 'C<sub>max</sub>,': [147, 192], 'AUC<sub>0–t</sub>': [148, 193], '95%': [152], 'upper': [153], 'confidence': [154], 'bound': [155], '(μT−μR)<sup>2</sup>−θσ<sup>2</sup>': [157], '<sub>WR</sub>': [158], '≤0,': [160], 'point': [163], 'estimates': [164], '(test-to-reference': [165], 'ratio)': [166], 'within': [168, 197], 'regulatory': [170, 199], 'acceptance': [171, 200], 'limit': [172, 201], '80.00–125.00%.': [173, 202], 'study': [176], 'variability<30%)': [178], '90%': [186], 'CI': [187], 'data': [190], 'AUC<sub>0–∞</sub>': [195], 'Based': [203], 'these': [205], 'aforesaid': [206], 'statistical': [207], 'inferences,': [208], 'it': [209], 'concluded': [211], 'that': [212], 'formulation': [215], 'is': [216], 'bioequivalent': [217]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2012695707', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2025-01-07T17:48:13.950022', 'created_date': '2016-06-24'}