Non-conventional Trafficking of the Cystic Fibrosis Transmembrane Conductance Regulator through the Early Secretory Pathway

Name: Work Video:
Duration: 3 min 30 s
Jin-San Yoo; Bryan D. Moyer; Sergei I. Bannykh; Hyeon-Mi Yoo; John R. Riordan; William E. Balch
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3819, 3824, 4202, 4277, 4340, 4344, 4388, 4398], 'cystic': [3, 32, 241, 270, 477, 595, 955, 964], 'fibrosis': [4, 242, 478, 488, 596, 956, 965], 'transmembrane': [5, 243, 479, 489, 957, 2794], 'conductance': [6, 244, 480, 490, 958], 'regulator': [7, 245, 481, 959], '(CFTR)': [8, 246, 482], 'trafficking': [9, 80, 160, 247, 318, 398, 682, 1012, 1127, 1144, 1589, 1668, 2009, 2155, 2483, 3880, 4211], 'from': [10, 46, 94, 121, 162, 248, 284, 332, 359, 400, 685, 891, 1013, 1063, 1100, 1112, 1310, 1315, 1323, 1341, 1352, 2291, 2801, 2995, 3112, 3262, 3422, 3473, 3530, 3549, 3808, 3881, 3900, 4177], 'the': [11, 16, 19, 26, 47, 75, 83, 95, 100, 122, 129, 148, 158, 163, 166, 172, 181, 207, 217, 231, 249, 254, 257, 264, 285, 313, 321, 333, 338, 360, 367, 386, 396, 401, 404, 410, 419, 445, 455, 469, 529, 575, 583, 592, 686, 691, 756, 835, 892, 902, 1014, 1017, 1026, 1056, 1064, 1094, 1101, 1106, 1122, 1129, 1134, 1143, 1164, 1177, 1191, 1209, 1225, 1250, 1255, 1472, 1596, 1781, 1798, 1988, 2004, 2011, 2073, 2114, 2117, 2121, 2139, 2154, 2159, 2267, 2270, 2275, 2282, 2292, 2415, 2424, 2481, 2497, 2500, 2624, 2629, 2632, 2656, 2691, 2701, 2760, 2781, 2786, 2789, 2802, 2810, 2986, 2996, 3030, 3040, 3044, 3063, 3069, 3106, 3121, 3137, 3147, 3158, 3165, 3173, 3220, 3240, 3246, 3251, 3257, 3263, 3418, 3423, 3427, 3430, 3474, 3501, 3508, 3515, 3531, 3534, 3539, 3543, 3555, 3614, 3619, 3634, 3670, 3693, 3698, 3757, 3764, 3772, 3787, 3809, 3820, 3839, 3882, 3885, 3905, 4009, 4096, 4107, 4178, 4182, 4187, 4200, 4213, 4275, 4278, 4341, 4386], 'endoplasmic': [12, 250, 687, 974, 2079], 'reticulum': [13, 251, 688, 975, 2080], '(ER)': [14, 252, 689], 'through': [15, 82, 171, 190, 253, 320, 409, 428, 901, 1128, 2113, 2158], 'Golgi': [17, 48, 255, 286, 903, 1065, 1113, 1174, 1185, 2085, 2429, 2625, 3535, 3540, 3552, 3641, 3685, 4041, 4111, 4216, 4285, 4394, 4405], 'apparatus,': [18, 256, 904], 'step': [20, 258, 3419], 'impaired': [21, 259], 'in': [22, 49, 107, 113, 206, 234, 260, 287, 345, 351, 444, 472, 532, 538, 574, 742, 1048, 1067, 1070, 1217, 1364, 1380, 1445, 1524, 1535, 1679, 1742, 1761, 1780, 2010, 2134, 2150, 2153, 2288, 2400, 2414, 2709, 2759, 3060, 3256, 3618, 3633, 3750, 3792, 3811, 3837, 4016, 4032, 4043, 4282], 'individuals': [23, 261], 'afflicted': [24, 262], 'with': [25, 263, 1367, 1401, 1434, 1461, 1467, 1533, 1552, 1559, 1608, 1631, 1730, 1753, 1806, 1817, 1836, 1872, 1882, 1887, 1906, 1912, 1956, 2084, 2407, 2485, 2504, 2615, 2700, 2861, 3007, 3029, 3151, 3202, 3245, 3626, 4022, 4038, 4269, 4392], 'prevalent': [27, 265], 'CFTR-ΔF508': [28, 266, 738, 812, 908, 1011, 1206], 'mutation': [29, 267], 'leading': [30, 268, 2422, 2654], 'to': [31, 128, 141, 165, 269, 366, 379, 403, 528, 588, 690, 1009, 1016, 1024, 1169, 1172, 1181, 1183, 1190, 1203, 1208, 1453, 1637, 1734, 1859, 1867, 2064, 2108, 2423, 2428, 2491, 2623, 2639, 2655, 2690, 2809, 3115, 3127, 3146, 3157, 3172, 3439, 3524, 3533, 3554, 3640, 3684, 3697, 3884, 3896, 3904, 4040, 4106, 4181, 4284, 4404], 'fibrosis,': [33, 271], 'is': [34, 43, 97, 272, 281, 335, 522, 752, 914, 1021, 1142, 1166, 3000, 3161, 3168, 3176, 3254, 3437, 3782, 4382], 'largely': [35, 44, 273, 282, 1061], 'unknown.': [36, 274], 'Recent': [37, 275], 'morphological': [38, 276, 1036, 3010], 'observations': [39, 277], 'suggested': [40, 278], 'that': [41, 90, 138, 188, 203, 223, 279, 328, 376, 426, 441, 461, 814, 1041, 1139, 1155, 2418, 3056, 3066, 3184, 3250, 3436, 3469, 3637, 3669, 3785, 3829, 4029, 4095], 'CFTR': [42, 93, 120, 169, 199, 204, 229, 280, 331, 358, 407, 437, 442, 467, 576, 684, 736, 751, 810, 883, 1032, 1044, 1098, 1126, 1148, 1156, 1230, 1565, 1676, 1943, 2008, 2068, 2112, 2289, 2406, 2486, 2622, 2687, 2706, 2758, 2994, 3016, 3028, 3111, 3124, 3128, 3155, 3170, 3188, 3216, 3227, 3625, 3760, 3767, 3773, 3780, 3807, 4017, 4021, 4175, 4188, 4270], 'absent': [45, 283, 1062], 'situ': [50, 288, 1071], '(Bannykh,': [51, 289], 'S.': [52, 290, 653, 701, 780, 840, 860, 928, 1489, 2036, 2372, 2726, 2938, 2963, 3305, 3353, 3378, 3484, 3730, 3932, 4222, 4292], 'I.,': [53, 56, 291, 294], 'Bannykh,': [54, 292], 'G.': [55, 293, 2248, 2309, 2592, 2879, 3280], 'Fish,': [57, 295], 'K.': [58, 296], 'N.,': [59, 297], 'Moyer,': [60, 298], 'B.': [61, 299, 643, 1287, 1483, 2030, 2096, 2187, 2531, 3591, 3864], 'D.,': [62, 300], 'Riordan,': [63, 301], 'J.': [64, 302, 625, 651, 699, 930, 943, 1265, 1293, 1423, 1700, 2099, 2173, 2190, 2203, 2218, 2221, 2253, 2314, 2352, 2444, 2463, 2517, 2534, 2547, 2562, 2565, 2597, 2665, 2728, 2740, 2830, 2849, 2884, 2902, 2917, 2940, 2944, 2947, 2961, 2968, 3087, 3285, 3332, 3355, 3359, 3362, 3376, 3383, 3402, 3654, 3711, 3732, 3735, 3917, 3943, 3971, 3991, 4056, 4081, 4126, 4151, 4410, 4413], 'R.,': [65, 303], 'and': [66, 219, 304, 457, 542, 681, 737, 744, 811, 894, 912, 1028, 1055, 1069, 1274, 1336, 1343, 1358, 1372, 1378, 1390, 1407, 1464, 1555, 1566, 1606, 1624, 1675, 1724, 1737, 1758, 1768, 1810, 1831, 1843, 1863, 1870, 1910, 1940, 1968, 1975, 2069, 2076, 2127, 2138, 2144, 2281, 2285, 2652, 2703, 3039, 3230, 3507, 3551, 3690, 3815, 3835, 3841, 3888, 4013, 4036, 4102, 4215, 4396], 'Balch,': [67, 305], 'W.': [68, 306], 'E.': [69, 307, 777], '(2000)': [70, 308], 'Traffic': [71, 309], '1,': [72, 310, 2680], '852–870),': [73, 311], 'raising': [74, 312], 'possibility': [76, 314], 'a': [78, 114, 135, 191, 196, 213, 316, 352, 373, 429, 434, 451, 523, 1160, 1220, 1245, 1275, 1381, 1518, 1536, 1837, 1978, 2017, 2409, 2492, 2616, 2773, 3003, 3023, 3132, 3191, 3197, 3205, 3628], 'novel': [79, 214, 317, 452], 'pathway': [81, 137, 161, 174, 210, 215, 319, 375, 399, 412, 448, 453, 1124, 1132, 1145, 1162, 1199, 2162, 2484], 'early': [84, 208, 322, 446, 1130, 2012, 2160], 'secretory': [85, 209, 323, 447, 1131, 2013, 2115, 2161], 'pathway.': [86, 324], 'We': [87, 201, 325, 439, 1118, 1137, 2264], 'now': [88, 326], 'report': [89, 327, 1138], 'export': [91, 329, 1099, 2290, 2992, 3258, 3421], 'ER': [96, 126, 164, 218, 334, 364, 402, 456, 743, 821, 1015, 1049, 1102, 2293, 2427, 3070, 3264, 3424, 3532, 3556, 3639, 3810, 3883, 3906, 4039, 4214, 4283, 4403], 'regulated': [98, 336], 'by': [99, 178, 337, 416, 826, 832, 1146, 1937, 1973, 2628, 2649, 2985, 3149, 3219, 3645], 'conventional': [101, 159, 339, 397], 'coat': [102, 340, 966, 970, 2122, 2128, 3046, 3431, 3510, 3517, 3648], 'protein': [103, 341, 495, 498, 520, 967, 971, 980, 1002, 1165, 1260, 1646, 1892, 2123, 2129, 2795], 'complex': [104, 342, 496, 499, 896, 968, 972, 1150, 1192, 2124, 2130, 2641, 3047, 3432, 3518, 4110], 'II': [105, 343, 969, 2125], '(COPII)': [106, 344, 2126], 'all': [108, 154, 346, 392, 1999], 'cell': [109, 115, 232, 347, 353, 470, 757, 1018, 1152, 1447, 2713], 'types': [110, 348], 'tested.': [111, 349, 2001], 'Remarkably,': [112, 350, 3746], 'type-specific': [116, 354, 1153], 'manner,': [117, 355], 'processing': [118, 356, 1189, 2648, 2787, 3156, 3171, 3217, 3620, 3694, 4105, 4176], 'core-glycosylated': [123, 361, 2634], '(band': [124, 131, 362, 369], 'B)': [125, 363], 'form': [127, 365, 2417, 2638, 2808, 3636, 3701], 'complex-glycosylated': [130, 368], 'C)': [132, 370], 'isoform': [133, 371, 2645], 'followed': [134, 372, 831], 'non-conventional': [136, 173, 374, 411, 1161, 1198], 'was': [139, 175, 195, 377, 413, 433, 1045, 1060, 1314, 1351, 1601, 1685, 1717, 2626, 2688, 2982, 3057, 3215, 3673], 'insensitive': [140, 378], 'dominant': [142, 380, 3152, 3629, 4026, 4195], 'negative': [143, 381, 3153, 3630, 4027, 4196], 'Arf1,': [144, 382], 'Rab1a/Rab2': [145, 383], 'GTPases,': [146, 384], 'or': [147, 385, 1790, 2477, 3771, 3803, 4024, 4186, 4209], 'SNApREceptor': [149, 387], '(SNARE)': [150, 388, 2147], 'component': [151, 389, 2498, 3042], 'syntaxin': [152, 185, 390, 423, 981, 4342], '5,': [153, 391], 'which': [156, 394, 586, 1147], 'block': [157, 395, 2396], 'Golgi.': [167, 405], 'Moreover,': [168, 406], 'transport': [170, 205, 408, 443, 746, 1052, 1207, 1672, 1712, 2082, 2110, 2135, 2430, 2979, 3527, 3537, 3545, 3642, 3794, 3799, 3899, 4042, 4204, 4286, 4390, 4406], 'potently': [176, 414, 2983, 4400], 'blocked': [177, 415, 3218, 3692, 4103], 'overexpression': [179, 417, 2767, 3747, 4397], 'late': [182, 192, 220, 420, 430, 458], 'endosomal': [183, 421, 1178], 'target-SNARE': [184, 422], '13,': [186, 424], 'suggesting': [187, 425, 3784], 'recycling': [189, 427, 3547, 3797], 'Golgi/endosomal': [193, 221, 431, 459], 'system': [194, 432, 1179, 2022], 'prerequisite': [197, 435], 'for': [198, 436, 1109, 1187, 1530, 1615, 1739, 1750, 1812, 1853, 1898, 1928, 1965, 1998, 3616, 3832, 4011, 4207, 4385], 'maturation.': [200, 438, 4271], 'conclude': [202, 440], 'can': [211, 449, 739, 1158], 'involve': [212, 450], 'between': [216, 454, 4212], 'compartments': [222, 460, 1175, 1186], 'may': [224, 462, 1200, 3522], 'influence': [225, 463], 'developmental': [226, 464], 'expression': [227, 465, 1640, 2021, 3186], 'on': [230, 468, 1671, 1815, 2785, 3002, 3756], 'surface': [233, 471, 758], 'polarized': [235, 473, 527], 'epithelial': [236, 474], 'cells.': [237, 475, 3813], '1The': [483], 'abbreviations': [484], 'used': [485, 1216, 2016, 2091], 'are:': [486], 'CFTRcystic': [487], 'regulatorArfADP-ribosylation': [491], 'factorBFAbrefeldin': [492], 'ACFcystic': [493], 'fibrosisCOPIIcoat': [494], 'IICOPIcoat': [497], 'IERendoplasmic': [500], 'reticulumVSV-Gvesicular': [501], 'stomatitis': [502, 977, 1257, 2797], 'virus': [503, 978, 1258, 1406, 1470, 2020, 2798], 'G': [504, 979, 1259], 'proteinSynsyntaxinendo': [505], 'Hendoglycosidase': [506], "HDMEMDulbecco's": [507], 'modified': [508, 985], "Eagle's": [509, 986, 1338, 1396, 1745], 'mediumBFAbrefeldin': [510], 'AVTCsvesicular': [511], 'tubular': [512, 991, 3445], 'elementsTGNtrans-Golgi': [513], 'networkCHOChinese': [514], 'hamster': [515, 996], 'ovarySNAREsoluble': [516], 'N-ethylmaleimide-sensitive': [517, 999], 'factor': [518, 961, 1000], 'attachment': [519, 1001], 'receptors': [521, 1003], 'cAMP-regulated': [524], 'chloride': [525], 'channel': [526], 'apical': [530], 'membrane': [531, 693, 2151], 'numerous': [533], 'epithelia': [534], 'including': [535], 'those': [536], 'found': [537, 3183], 'lung,': [539], 'pancreas,': [540], 'intestine,': [541], 'kidney': [543], '(1.Stanton': [544], 'B.A.': [545], 'Wien.': [546], 'Klin.': [547], 'Wochenschr.': [548], '1997;': [549, 561, 766], '109:': [550], '457-464PubMed': [551], 'Google': [552, 565, 616, 636, 673, 720, 732, 770, 792, 804, 853, 877, 937, 953, 1091, 1243, 1272, 1301, 1432, 1497, 1515, 1586, 1662, 1709, 1926, 2044, 2062, 2106, 2182, 2197, 2213, 2231, 2262, 2323, 2338, 2361, 2393, 2453, 2472, 2526, 2541, 2557, 2575, 2606, 2677, 2735, 2750, 2839, 2858, 2893, 2911, 2931, 2956, 2977, 3101, 3294, 3326, 3346, 3371, 3392, 3416, 3467, 3496, 3570, 3588, 3610, 3664, 3721, 3744, 3859, 3874, 3926, 3952, 3965, 3985, 4005, 4065, 4090, 4135, 4160, 4234, 4249, 4264, 4304, 4319, 4334, 4362, 4377, 4423], 'Scholar,': [553, 617, 637, 721, 771, 793, 854, 938, 1498, 2045, 2183, 2198, 2214, 2232, 2324, 2339, 2362, 2454, 2527, 2542, 2558, 2576, 2840, 2912, 2932, 2957, 3295, 3327, 3347, 3372, 3393, 3571, 3589, 3722, 3860, 3953, 3966, 3986, 4066, 4136, 4235, 4250, 4305, 4320, 4363, 4424], '2.Jilling': [554], 'T.': [555, 760, 2240, 2301, 2341, 2368, 2433, 2460, 2584, 2819, 2846, 2871, 2899, 3272, 3301, 3399, 3480, 3595, 4218, 4288], 'Kirk': [556, 761], 'K.L.': [557, 762], 'Int.': [558, 763, 2331, 3563], 'Rev.': [559, 725, 764, 797, 2332, 3564, 3849, 4352, 4369], 'Cytol.': [560, 765, 2333, 3565], '172:': [562, 767], '193-241Crossref': [563, 768], 'PubMed': [564, 613, 633, 670, 717, 729, 769, 789, 801, 850, 874, 934, 952, 1088, 1240, 1269, 1298, 1429, 1494, 1512, 1583, 1659, 1706, 1923, 2041, 2059, 2105, 2179, 2196, 2212, 2230, 2259, 2320, 2337, 2358, 2390, 2450, 2469, 2523, 2540, 2556, 2574, 2603, 2674, 2732, 2749, 2836, 2855, 2890, 2908, 2928, 2953, 2974, 3098, 3291, 3323, 3343, 3368, 3389, 3413, 3464, 3493, 3569, 3585, 3607, 3663, 3720, 3741, 3856, 3871, 3923, 3949, 3962, 3982, 4002, 4062, 4087, 4132, 4157, 4231, 4246, 4261, 4301, 4316, 4331, 4359, 4374, 4422], 'Scholar).': [566, 674, 733, 805, 878, 954, 1092, 1302, 1663, 1710, 2263, 2394, 2473, 2751, 2859, 3102, 3497, 3611, 3665, 3745, 3875, 4006, 4091, 4335, 4378], 'Although': [567], 'nearly': [568], '1000': [569], 'mutations': [570], 'have': [571, 1119], 'been': [572, 2090, 3894], 'identified': [573], 'gene,': [577], '∼70%': [578], 'CF': [580], 'chromosomes': [581], 'contain': [582], 'ΔF508': [584, 3064], 'mutation,': [585], 'leads': [587, 2490], 'severe': [589], 'forms': [590], 'genetic': [593], 'disease': [594], '(CF)': [597], '(3.Mickle': [598], 'J.E.': [599, 2250, 2311, 2594, 2881, 3282, 3575], 'Cutting': [600], 'G.R.': [601], 'Clin.': [602], 'Chest': [603], 'Med.': [604, 629], '1998;': [605, 786, 1237, 2971, 3386, 3490, 3868, 3994, 4228, 4298], '19:': [606], '443-458Abstract': [607], 'Full': [608, 610, 714, 847, 871, 949, 2209, 2227, 2387, 2553, 2571, 2746, 2923, 2925, 3093, 3095, 3320, 3338, 3340, 3408, 3410, 3580, 3582, 3602, 3604, 3660, 3717, 3977, 3979, 3997, 3999, 4419], 'Text': [609, 611, 715, 848, 872, 950, 2210, 2228, 2388, 2554, 2572, 2747, 2924, 2926, 3094, 3096, 3321, 3339, 3341, 3409, 3411, 3581, 3583, 3603, 3605, 3661, 3718, 3978, 3980, 3998, 4000, 4420], 'PDF': [612, 716, 849, 873, 951, 2211, 2229, 2389, 2555, 2573, 2748, 2927, 3097, 3322, 3342, 3412, 3584, 3606, 3662, 3719, 3981, 4001, 4421], 'Scopus': [614, 634, 671, 718, 730, 790, 802, 851, 875, 935, 1089, 1241, 1270, 1299, 1430, 1495, 1513, 1584, 1660, 1707, 1924, 2042, 2060, 2180, 2260, 2321, 2359, 2391, 2451, 2470, 2524, 2604, 2675, 2733, 2837, 2856, 2891, 2909, 2929, 2954, 2975, 3099, 3292, 3324, 3344, 3369, 3390, 3414, 3465, 3494, 3586, 3608, 3742, 3857, 3872, 3924, 3950, 3963, 3983, 4003, 4063, 4088, 4133, 4158, 4232, 4247, 4262, 4302, 4317, 4332, 4360, 4375], '(63)': [615, 3609], '4.Davis': [618], 'P.B.': [619], 'Drumm': [620, 658], 'M.': [621, 775, 2242, 2246, 2303, 2307, 2328, 2343, 2370, 2378, 2380, 2435, 2456, 2586, 2590, 2821, 2842, 2873, 2877, 2895, 2914, 2934, 2959, 3274, 3278, 3303, 3311, 3313, 3329, 3349, 3374, 3395, 3560, 3845], 'Konstan': [622], 'M.W.': [623], 'Am.': [624, 3086], 'Respir.': [626], 'Crit.': [627], 'Care': [628], '1996;': [630, 2355, 2447, 2833, 3974], '154:': [631], '1229-1256Crossref': [632], '(839)': [635], '5.Riordan': [638], 'J.R.': [639, 866, 926, 1081, 1234, 1416, 1693, 2166, 2510, 2724, 3085, 3457, 3910, 3936, 4049, 4119], 'Rommens': [640], 'J.M.': [641, 2345, 2437, 2823, 4072, 4142], 'Kerem': [642], 'Alon': [644], 'N.': [645, 655, 922, 1232, 2374, 2720, 3307], 'Rozmahel': [646], 'R.': [647, 782, 1418, 1695, 2168, 2382, 2512, 3315, 3593, 3912, 3934, 3938, 4051, 4121, 4365], 'Grzelczak': [648], 'Z.': [649], 'Zielenski': [650], 'Lok': [652], 'Plavsic': [654], 'Chou': [656], 'J.L.': [657], 'M.L.': [659], 'Iannuzzi': [660], 'M.C.': [661, 3728], 'Collins': [662], 'F.S.': [663], 'Tsui': [664], 'L.C.': [665], 'Science.': [666, 3489, 4227, 4242, 4297, 4312], '1989;': [667], '245:': [668], '1066-1073Crossref': [669], '(6139)': [672], 'Deletion': [675], 'F508': [677], 'prevents': [678], 'proper': [679], 'folding': [680], 'plasma': [692, 1057, 1210], '(6.Cheng': [694], 'S.H.': [695, 2669], 'Gregory': [696], 'R.J.': [697], 'Marshall': [698, 2664], 'Paul': [700], 'Souza': [702], 'D.W.': [703], 'White': [704], 'G.A.': [705], "O'Riordan": [706], 'C.R.': [707, 2661], 'Smith': [708], 'A.E.': [709], 'Cell.': [710, 843, 867, 2383, 3316, 3576, 3851, 3958, 4354], '1990;': [711, 1295, 1509, 2056], '63:': [712], '827-834Abstract': [713], '(1459)': [719], '7.Kopito': [722], 'R.R.': [723, 842, 942, 2739], 'Physiol.': [724, 796], '1999;': [726, 798, 2102, 2193, 2537, 3090, 3405, 3959, 4371], '79:': [727, 799], '167-173Crossref': [728], '(376)': [731], 'Both': [734, 806], 'wild-type': [735, 750, 809, 882, 1031, 1043, 1564, 2007, 2067, 2405, 3015, 3027, 3806], 'be': [740, 1170, 1201], 'detected': [741], 'ER-Golgi': [745, 1051], 'intermediates,': [747, 1053], 'but': [748, 1154, 3223], 'only': [749, 1141, 3214], 'readily': [753, 1046], 'expressed': [754, 4101], 'at': [755, 1133, 1386, 1517, 1541, 1850, 1856, 1879, 1895, 1931, 1993], '(2.Jilling': [759], '8.Gilbert': [772], 'A.': [773, 920, 1289, 1291, 1490, 2037, 2718], 'Jadot': [774], 'Leontieva': [776], 'Wattiaux-De': [778], 'Coninck': [779], 'Wattiaux': [781], 'Exp.': [783], 'Cell': [784, 1424, 1701, 2100, 2174, 2191, 2254, 2315, 2353, 2445, 2464, 2518, 2535, 2598, 2831, 2850, 2885, 2903, 2948, 2969, 3286, 3363, 3384, 3597, 3736, 3918, 3944, 4057, 4082, 4127, 4152], 'Res.': [785], '242:': [787], '144-152Crossref': [788], '(66)': [791], '9.Bradbury': [794], 'N.A.': [795], '175-191Crossref': [800], '(142)': [803], 'newly': [807], 'synthesized': [808], 'molecules': [813], 'neither': [815, 3786, 4170], 'fold': [816], 'productively': [817], 'nor': [818, 3795, 4172], 'achieve': [819], 'an': [820, 1616], 'export-competent': [822], 'conformation': [823], 'are': [824, 889, 3243, 3470, 3817, 3830, 4030], 'eliminated': [825], 'covalent': [827], 'addition': [828, 2657], 'ubiquitin': [830], 'degradation': [833, 3235, 3804], 'via': [834], 'proteosome': [836], '(10.Ward': [837], 'C.L.': [838, 940, 2737], 'Omura': [839], 'Kopito': [841, 941, 2738], '1995;': [844, 868, 1580, 1656, 2466, 2852, 2905], '83:': [845, 869, 1492, 2039], '121-127Abstract': [846], '(1144)': [852], '11.Jensen': [855], 'T.J.': [856], 'Loo': [857], 'M.A.': [858], 'Pind': [859, 3931], 'Williams': [861], 'D.B.': [862], 'Goldberg': [863], 'A.L.': [864, 2663], 'Riordan': [865, 925, 1080, 1233, 2723, 3456], '129-135Abstract': [870], '(777)': [876], 'Whereas': [879, 3239], '∼20–40%': [880], 'nascent': [884], 'chains': [885], 'become': [886], 'properly': [887], 'folded,': [888], 'exported': [890], 'ER,': [893, 2997], 'acquire': [895], 'carbohydrates': [897, 1151], 'characteristic': [898], 'passage': [900], 'negligible': [905], 'levels': [906, 1641, 1647, 1792, 2756], 'follow': [909], 'this': [910, 1197, 1218, 3008, 3180], 'pathway,': [911, 2014, 2116], 'CFTR-Δ508': [913], 'quantitatively': [915, 3104], 'degraded': [916], '(12.Lukacs': [917, 2715], 'G.L.': [918, 2716], 'Mohamed': [919, 2717], 'Kartner': [921, 2719], 'Chang': [923, 2721], 'X.B.': [924, 2722], 'Grinstein': [927, 2725], 'EMBO': [929, 1264, 2727], '1994;': [931, 946, 2206, 2224, 2256, 2317, 2384, 2550, 2568, 2600, 2729, 2743, 2887, 3288, 3317, 3657, 3714, 3738, 4084, 4154, 4416], '13:': [932, 2730], '6076-6086Crossref': [933, 2731], '(346)': [936, 2734], '13.Ward': [939], 'Biol.': [944, 1425, 1702, 2175, 2204, 2222, 2255, 2316, 2354, 2446, 2465, 2519, 2548, 2566, 2599, 2741, 2832, 2851, 2886, 2904, 2918, 2949, 2970, 3287, 3333, 3364, 3385, 3403, 3598, 3655, 3712, 3737, 3852, 3919, 3945, 3957, 3972, 3992, 4058, 4083, 4128, 4153, 4355, 4414], 'Chem.': [945, 2205, 2223, 2549, 2567, 2742, 2919, 3334, 3404, 3656, 3713, 3973, 3993, 4415], '269:': [947, 2207, 2225, 2551, 2569, 2744, 3658, 3715, 4417], '25710-25718Abstract': [948, 2745], 'ADP-ribosylation': [960], 'brefeldin': [962, 988, 1787], 'A': [963, 989, 1788], 'I': [973, 1331, 1463, 1529, 2131, 3433], 'vesicular': [976, 990, 1256, 2482, 2796, 3444], 'endoglycosidase': [982, 2803], 'H': [983, 2804], "Dulbecco's": [984], 'medium': [987, 1339, 1397, 1600, 1716, 1783], 'elements': [992], 'trans-Golgi': [993], 'network': [994, 3887], 'Chinese': [995], 'ovary': [997], 'soluble': [998], 'To': [1004, 2002, 2395, 3103, 3612, 4007], 'rationally': [1005], 'develop': [1006], 'therapeutic': [1007], 'means': [1008], 'stimulate': [1010, 1205], 'surface,': [1019], 'it': [1020, 1059, 3679], 'first': [1022, 1167, 2265], 'necessary': [1023], 'understand': [1025], 'mechanisms': [1027], 'pathways': [1029, 3843], 'directing': [1030], 'trafficking.': [1033], 'By': [1034, 2752, 3178], 'using': [1035, 1591, 1629, 1947, 1977, 3017, 3179], 'analyses,': [1037], 'we': [1038, 2015, 2403, 2778, 3119, 3182, 3623, 4019], 'recently': [1039], 'reported': [1040, 2708, 3705, 4114], 'although': [1042, 3185], 'detectable': [1047, 2755], 'membranes,': [1050, 4395], 'endosomes,': [1054], 'membrane,': [1058], 'stack': [1066], 'vivo': [1068], '(14.Bannykh': [1072, 3448], 'S.I.': [1073, 2458, 2844, 2897, 3397, 3449], 'Bannykh': [1074, 2457, 2843, 2896, 2937, 2962, 3352, 3377, 3396, 3450, 3483, 4221, 4291], 'G.I.': [1075, 3451], 'Fish': [1076, 2935, 3350, 3452], 'K.N.': [1077, 2936, 3351, 3453], 'Moyer': [1078, 3454, 4238, 4308], 'B.D.': [1079, 3455, 4239, 4252, 4309, 4322], 'Balch': [1082, 1421, 1576, 1652, 1698, 2171, 2201, 2219, 2251, 2312, 2350, 2442, 2461, 2515, 2545, 2563, 2595, 2828, 2847, 2882, 2900, 2915, 2945, 2966, 3283, 3330, 3360, 3381, 3400, 3458, 3487, 3652, 3709, 3915, 3941, 3969, 4054, 4079, 4124, 4149, 4225, 4240, 4255, 4295, 4310, 4325, 4411], 'W.E.': [1083, 1422, 1577, 1653, 1699, 2172, 2202, 2220, 2252, 2313, 2351, 2443, 2462, 2516, 2546, 2564, 2596, 2829, 2848, 2883, 2901, 2916, 2946, 2967, 3284, 3331, 3361, 3382, 3401, 3459, 3488, 3653, 3710, 3916, 3942, 3970, 4055, 4080, 4125, 4150, 4226, 4241, 4256, 4296, 4311, 4326, 4412], 'Traffic.': [1084, 3460, 4257, 4327], '2000;': [1085, 2334, 2671, 2920, 3335, 3461, 3566, 3577, 3599, 4243, 4313], '1:': [1086, 3462], '852-870Crossref': [1087, 3463], '(57)': [1090, 3466], 'However,': [1093], 'molecular': [1095, 1135, 2277, 3503, 3826], 'mechanism': [1096], 'as': [1103, 1105, 1398, 1411, 1687, 1795, 2815, 3131, 3678, 3704, 4113], 'well': [1104], 'biochemical': [1107], 'foundation': [1108], 'its': [1110, 3232], 'absence': [1111], 'cisternae': [1114], 'were': [1115, 1215, 1309, 1322, 1340, 1362, 1393, 1409, 1443, 1458, 1546, 1549, 1557, 1627, 1677, 1726, 1748, 1778, 1803, 1848, 1865, 1885, 1902, 1935, 1945, 1954, 1971, 2764, 4099], 'not': [1116, 1140, 1635, 2609, 3162, 3213, 3688, 4267], 'addressed.': [1117], 'therefore': [1120], 'examined': [1121, 2266], 'biosynthetic': [1123], 'level.': [1136], 'acquires': [1149], 'maturation': [1157, 2707, 3109, 3781], 'utilize': [1159], 'whereby': [1163], 'likely': [1168], 'transported': [1171], 'distal': [1173], 'and/or': [1176, 3542], 'prior': [1180, 1452], 'retrieval': [1182], 'earlier': [1184], 'oligosaccharide': [1188], 'form.': [1193], 'Pharmacological': [1194], 'modulation': [1195], 'useful': [1202], 'selectively': [1204], 'membrane.': [1211], 'following': [1213, 1595, 2766, 3420], 'antibodies': [1214, 1633], 'study:': [1219], 'monoclonal': [1221, 1246, 1874], 'antibody': [1222, 1247, 1277, 1875], '(M3A7)': [1223], 'against': [1224, 1249, 1278], 'second': [1226], 'nucleotide-binding': [1227], 'domain': [1228], '(15.Kartner': [1231], 'Methods': [1235, 1507, 1578, 1654, 2054], 'Enzymol.': [1236, 1508, 1579, 1655, 2055], '292:': [1238], '629-652Crossref': [1239], '(24)': [1242], 'Scholar),': [1244, 1273, 2978, 3417], '(p5D4)': [1248], 'C-terminal': [1251], 'cytoplasmic': [1252], 'tail': [1253], '(VSV-G)': [1261, 2800], '(16.Kreis': [1262], 'T.E.': [1263, 2330, 3562], '1986;': [1266, 1491, 2038], '5:': [1267], '931-941Crossref': [1268], '(298)': [1271], 'polyclonal': [1276], 'Rab6': [1279], '(B.': [1280], 'Goud,': [1281], 'Institut': [1282], 'Curie,': [1283], 'Paris,': [1284], 'France)': [1285], '(17.Goud': [1286], 'Zahraoui': [1288], 'Tavitian': [1290], 'Saraste': [1292], 'Nature.': [1294, 1919], '345:': [1296], '553-556Crossref': [1297], '(275)': [1300], 'Protein': [1303, 1347], 'G-Sepharose': [1304, 1893], '4': [1305, 1857, 1880, 1896, 1904], 'Fast': [1306], 'Flow': [1307], 'beads': [1308, 1894], 'Amersham': [1311], 'Biosciences;': [1312], 'BFA': [1313], 'Calbiochem;': [1316], 'Complete': [1317, 1838], 'Protease': [1318, 1839], 'Inhibitor': [1319, 1840], 'Cocktail': [1320, 1841], 'Tablets': [1321], 'Roche': [1324], 'Molecular': [1325], 'Biochemicals;': [1326], 'LipofectAMINE': [1327, 1592], 'Plus': [1328, 1593], 'Reagent,': [1329, 1594], 'Opti-MEM': [1330, 1462, 1528, 1553], 'reduced': [1332, 3059, 3231], 'serum': [1333, 1371, 1614, 1767], 'medium,': [1334], 'DMEM,': [1335], 'α-minimum': [1337, 1395], 'Invitrogen;': [1342], 'Easy': [1344], 'Tag': [1345], 'Express': [1346], 'Labeling': [1348], '35S-Met': [1349], 'Mix': [1350], 'PerkinElmer': [1353], 'Life': [1354], 'Sciences.': [1355], 'BHK,': [1356], 'HeLa,': [1357], 'HEK-': [1359], '293T': [1360], 'cells': [1361, 1392, 1439, 1457, 1548, 1556, 1725, 1777, 1802, 2614, 3013, 3061, 3752, 4045], 'maintained': [1363, 1394], 'DMEM': [1365, 1609, 1762], 'supplemented': [1366, 1835], '10%': [1368, 1611, 1764], 'fetal': [1369, 1612, 1765], 'bovine': [1370, 1613], '100': [1373], 'units/ml': [1374], 'each': [1375], 'penicillin': [1377], 'streptomycin': [1379], '5%': [1382, 1537], 'humidified': [1383, 1538], 'CO2': [1384, 1539], 'incubator': [1385, 1540], '37': [1387, 1542, 1735], '°C.': [1388, 1543], 'CHO': [1389], 'CHO-15B': [1391], 'above.': [1399], 'Infection': [1400, 1544], 'T7': [1402, 1473], 'RNA': [1403, 1474], 'polymerase-recombinant': [1404], 'vaccinia': [1405, 1469], 'transfection': [1408], 'performed': [1410, 1678, 1686], 'described': [1412, 1688, 2816], '(18.Tisdale': [1413, 1690, 2163, 2507, 3907, 4046, 4116], 'E.J.': [1414, 1575, 1651, 1691, 2164, 2508, 3908, 3955, 3968, 3988, 4047, 4117], 'Bourne': [1415, 1692, 2165, 2509, 3909, 3935, 4048, 4118], 'Khosravi-Far': [1417, 1694, 2167, 2511, 3911, 3933, 4050, 4120], 'Der': [1419, 1696, 2169, 2513, 3913, 3939, 4052, 4122], 'C.J.': [1420, 1697, 2170, 2514, 3724, 3914, 3940, 4053, 4123], '1992;': [1426, 1703, 2176, 2520, 3920, 4059, 4129], '119:': [1427, 1704, 2177, 2521, 3921, 4060, 4130], '749-761Crossref': [1428, 1705, 2178, 2522, 3922, 4061, 4131], '(425)': [1431, 1708, 2181, 2525, 3925, 4064, 4134], 'Scholar)': [1433, 1516, 1587, 1927, 2063, 2107, 2607, 2678, 3468, 4161, 4265], 'minor': [1435], 'modifications.': [1436], 'Briefly,': [1437], 'BHK': [1438, 2401, 3751, 3812, 4044], '(1.5': [1440], '×': [1441], '106)': [1442], 'plated': [1444], '60-mm': [1446], 'culture': [1448], 'dishes': [1449], '1': [1450, 1525, 1844, 1929, 1966, 2793], 'day': [1451], 'experimentation.': [1454], 'Before': [1455], 'infection,': [1456], 'washed': [1459, 1550, 1727, 1804, 1903], 'twice': [1460, 1551, 1805], 'then': [1465, 1759], 'infected': [1466], 'recombinant': [1468, 1622, 2018], 'expressing': [1471, 3014, 3062], 'polymerase': [1475], '(19.Fuerst': [1476, 2023], 'T.R.': [1477, 2024], 'Niles': [1478, 2025], 'E.G.': [1479, 2026], 'Studier': [1480, 2027], 'F.W.': [1481, 1500, 2028, 2047], 'Moss': [1482, 2029], 'Proc.': [1484, 2031], 'Natl.': [1485, 2032], 'Acad.': [1486, 2033], 'Sci.': [1487, 2034, 2101, 2192, 2536], 'U.': [1488, 2035], '8122-8126Crossref': [1493, 2040], '(1952)': [1496, 2043], '20.Studier': [1499, 2046], 'Rosenberg': [1501, 2048], 'A.H.': [1502, 2049], 'Dunn': [1503, 2050], 'J.J.': [1504, 2051], 'Dubendorff': [1505, 2052], 'J.W.': [1506, 2053], '185:': [1510, 2057], '60-89Crossref': [1511, 2058], '(6225)': [1514, 2061], 'multiplicity': [1519], '10': [1521, 1769, 1854], 'plaque-forming': [1522], 'units/cell': [1523], 'ml': [1526], '30': [1531, 1740, 1813], 'min': [1532, 1741, 1752, 1814, 1855], 'rocking': [1534], 'media': [1545], 'removed;': [1547], 'I,': [1554], 'co-transfected': [1558], '7': [1560, 1567], 'μg': [1561, 1568], 'pcDNA3.1': [1563], 'pcDNA3.1/pET': [1570], 'vector': [1571], '(21.Dascher': [1572, 1648], 'C.': [1573, 1649, 2200, 2216, 2236, 2297, 2349, 2364, 2441, 2544, 2560, 2580, 2827, 2867, 2965, 3268, 3297, 3380, 3482, 3651, 3708, 4070, 4140, 4220, 4290, 4408], 'Tisdale': [1574, 1650], '257:': [1581, 1657], '165-173Crossref': [1582, 1658], '(5)': [1585, 1661], 'containing': [1588, 1610, 1763, 1784, 1942, 3036, 3052, 3074, 3080], 'machinery': [1590, 1669, 3253, 3435, 4280, 4337], "manufacturer's": [1597], 'instructions.': [1598], 'Transfection': [1599], 'aspirated': [1602], 'after': [1603, 1719, 3196], '3': [1604, 1899, 2697], 'h': [1605, 1721, 1930, 1967], 'replaced': [1607], 'additional': [1617], '5–7': [1618], 'h.': [1619, 1900], 'Expression': [1620], 'GTPases': [1623, 2143, 3828, 4198, 4273], 'SNARE': [1625, 4345], 'components': [1626, 1670, 2071, 2479, 3499, 3548, 3800], 'verified': [1628], 'immunoblotting': [1630], 'specific': [1632], '(data': [1634, 2608, 3687], 'shown)': [1636, 3689], 'ensure': [1638], 'typical': [1639], '5–10-fold': [1643, 2493], 'over': [1644, 2499, 2696], 'endogenous': [1645, 2501], 'Experiments': [1664], 'comparing': [1665], 'effects': [1666], 'VSV-G': [1674, 1684, 2981, 3644, 3696, 4104, 4402], 'parallel.': [1680], 'Transport': [1681], 'analysis': [1682, 1713], 'previously': [1689, 2092, 2817, 3706, 4115], 'For': [1711, 1773], 'CFTR,': [1715, 3622], 'removed': [1718], '8–10': [1720], 'transfection,': [1723], 'two': [1728], 'times': [1729, 1905], 'phosphate-buffered': [1731, 1808], 'saline': [1732, 1809], '(pre-warmed': [1733], '°C)': [1736], 'incubated': [1738, 1871], 'methionine-deficient': [1743], 'minimum': [1744], 'medium.': [1746], 'Cells': [1747], 'radiolabeled': [1749], '20–30': [1751], '500': [1754], 'μCi': [1755], 'Trans35S-label': [1757], 'chased': [1760, 1779], 'calf': [1766], 'mm': [1770, 1821, 1960], 'cold': [1771], 'methionine.': [1772], 'experiments': [1774, 1997, 3667, 4093], 'utilizing': [1775], 'BFA,': [1776], 'above': [1782, 3241], '5': [1785, 4380], 'μg/ml': [1786], '(BFA)': [1789], 'equivalent': [1791], 'ethanol': [1794], 'control.': [1796], 'After': [1797], 'indicated': [1799], 'chase': [1800, 3199], 'periods,': [1801], 'ice-cold': [1807, 1907], 'lysed': [1811], 'ice': [1816], 'RIPA': [1818, 1908], 'buffer': [1819, 1909, 1916], '(50': [1820], 'Tris-HCl': [1822], '(pH': [1823], '7.4),': [1824], '150': [1825], 'mmNaCl,': [1826], '0.1%': [1827], 'SDS,': [1828], '1%': [1829, 1832], 'deoxycholate,': [1830], 'Triton': [1833], 'X-100)': [1834], 'Tablet': [1842], 'mmphenylmethylsulfonyl': [1845], 'fluoride.': [1846], 'Lysates': [1847], 'spun': [1849], '14,000': [1851], '×g': [1852], '°C': [1858, 1881, 1897], 'pellet': [1860], 'insoluble': [1861], 'material,': [1862], 'supernatants': [1864], 'transferred': [1866], 'fresh': [1868], 'tubes': [1869], 'M3A7': [1873], '(5': [1876], 'μg/ml)': [1877], 'overnight': [1878], 'rotation.': [1883], 'Immunoprecipitates': [1884], 'isolated': [1886], '50': [1888], 'μl': [1889], '50%': [1891], 'Beads': [1901, 1934], 'eluted': [1911], '1×': [1913], 'Laemmli': [1914], 'sample': [1915], '(22.Laemmli': [1917], 'U.K.': [1918], '1970;': [1920], '227:': [1921], '680-685Crossref': [1922], '(212847)': [1925], 'room': [1932], 'temperature.': [1933], 'pelleted': [1936], 'brief': [1938], 'centrifugation,': [1939], 'supernatants,': [1941], 'protein,': [1944], 'separated': [1946], '7.5%': [1948], 'SDS-PAGE': [1949], 'gels.': [1950], 'Following': [1951, 2611], 'electrophoresis,': [1952], 'gels': [1953], 'treated': [1955], 'enhancing': [1957], 'solution': [1958], '(125': [1959], 'sodium': [1961], 'salicylate,': [1962], '35%': [1963], 'methanol)': [1964], 'dried.': [1969], 'Signals': [1970], 'developed': [1972], 'autoradiography': [1974], 'quantitated': [1976], 'PhosphorImager': [1979], 'SI': [1980], '(Molecular': [1981], 'Dynamics,': [1982], 'Sunnyvale,': [1983], 'CA).': [1984], 'Graphical': [1985], 'results': [1986, 2506, 3242], 'represent': [1987], 'mean': [1989], '±': [1990], 'S.E.': [1991], 'least': [1994], 'three': [1995], 'independent': [1996], 'conditions': [2000, 2777, 3677], 'investigate': [2003, 3613], 'T7-vaccinia': [2019], 'transiently': [2065], 'co-express': [2066], 'key': [2070], 'regulating': [2072], 'formation,': [2074, 3770], 'targeting,': [2075], 'fusion': [2077, 2152, 3475, 3836, 4387], '(ER)-derived': [2081], 'intermediates': [2083, 2431, 3441, 3903, 4205], 'membranes.': [2086], 'This': [2087, 4336], 'approach': [2088], 'has': [2089, 3893], '(23.Ostedgaard': [2093], 'L.S.': [2094, 2185, 2529], 'Zeiher': [2095, 2186, 2530], 'Welsh': [2097, 2188, 2532], 'M.J.': [2098, 2189, 2533], '112:': [2103, 2194, 2538], '2091-2098Crossref': [2104, 2195, 2539], 'examine': [2109, 4008], 'functional': [2118, 3674], 'roles': [2119], '(COPI)': [2132, 3434], 'involved': [2133, 2149, 3255, 4281], 'vesicle': [2136, 2398, 2420, 3833], 'assembly,': [2137], 'role': [2140, 2268, 3789], 'Rab': [2142, 3822, 4097, 4197, 4272], 'SNAp': [2145], 'REceptor': [2146], 'proteins': [2148, 3261, 4346], 'cargo': [2157, 2791, 3260], '23.Ostedgaard': [2184, 2528], '24.Dascher': [2199, 2543], '1437-1448Abstract': [2208, 2552, 3659, 3716], '25.Dascher': [2215, 2559], 'Matteson': [2217, 2561, 4409], '29363-29366Abstract': [2226, 2570, 4418], '26.Kuge': [2233, 2577], 'O.': [2234, 2295, 2578, 2865, 3266, 3862], 'Dascher': [2235, 2296, 2579, 2866, 3267, 3481, 4219, 4289], 'Orci': [2237, 2298, 2365, 2581, 2868, 3269, 3298], 'L.': [2238, 2299, 2366, 2582, 2869, 3270, 3299], 'Rowe': [2239, 2300, 2459, 2583, 2845, 2870, 2898, 3271, 3398], 'Amherdt': [2241, 2302, 2379, 2585, 2872, 3273, 3312], 'Plutner': [2243, 2304, 2346, 2438, 2587, 2824, 2874, 3275, 3485, 4073, 4143, 4223, 4293], 'H.': [2244, 2305, 2347, 2439, 2588, 2825, 2875, 3276, 3486, 3847, 3928, 4074, 4144, 4224, 4294], 'Ravazzola': [2245, 2306, 2377, 2589, 2876, 3277, 3310], 'Tanigawa': [2247, 2308, 2591, 2878, 3279], 'Rothman': [2249, 2310, 2593, 2880, 3281, 3574], '125:': [2257, 2318, 2601, 2888, 3289, 4085, 4155], '51-65Crossref': [2258, 2319, 2602, 2889, 3290], '(254)': [2261, 2322, 2605, 2892, 3293], 'COPII': [2271, 2397, 3045, 3252, 3477, 4389], 'complex,': [2272], 'composed': [2273], 'small': [2276, 3502, 3825], 'weight': [2278, 3504, 3827], 'GTPase': [2279, 3032, 3505], 'Sar1': [2280, 2476, 3031, 3035, 3073], 'heterodimeric': [2283], 'Sec23–24': [2284], 'Sec13–31': [2286], 'complexes': [2287], '(26.Kuge': [2294, 2864, 3265], '27.Scales': [2325], 'S.J.': [2326, 3558], 'Gomez': [2327, 3559], 'Kreis': [2329, 3561], '195:': [2335, 3567], '67-144Crossref': [2336, 3568], '28.Rowe': [2340], 'Aridor': [2342, 2434, 2820], 'McCaffery': [2344, 2436, 2822, 4071, 4141], 'Nuoffer': [2348, 2440, 2826, 4069, 4139], '135:': [2356, 2448, 2834], '895-911Crossref': [2357, 2449, 2835], '(152)': [2360, 2452, 2838], '29.Barlowe': [2363, 3296], 'Yeung': [2367, 3300], 'Hosobuchi': [2369, 3302], 'Hamamoto': [2371, 3304], 'Salama': [2373, 3306], 'Rexach': [2375, 3308], 'M.F.': [2376, 3309], 'Schekman': [2381, 3314], '77:': [2385, 3318], '895-907Abstract': [2386, 3319], '(1075)': [2392, 3325], 'function': [2399, 3133, 3513, 3523, 4015, 4201], 'cells,': [2402, 2684], 'co-expressed': [2404, 3624, 4020], 'Sar1-GTP(H79G),': [2408], 'constitutively': [2410], 'active': [2411], 'mutant': [2412, 2988, 3065, 3222, 3631, 3672], 'locked': [2413, 3632], 'GTP-bound': [2416, 3635], 'inhibits': [2419, 3638, 4401], 'uncoating': [2421], 'accumulation': [2425], '(28.Rowe': [2432, 2818], '30.Aridor': [2455, 2841], '131:': [2467, 2853, 2906], '875-893Crossref': [2468, 2854, 2907], '(349)': [2471, 2857, 2910], 'Co-expression': [2474], 'other': [2478, 2710], '(see': [2487], 'below)': [2488], 'generally': [2489, 3247, 3425], 'elevated': [2494], 'level': [2495], 'pool,': [2502], 'consistent': [2503, 2699, 3244], 'previous': [2505, 2862], 'shown).': [2610], 'labeling': [2612], 'pulse': [2617], '[35S]methionine,': [2619], 'delivery': [2620], 'measured': [2627], 'conversion': [2630], '∼140–150-kDa': [2633], 'band': [2635, 2643, 2693, 2761, 3113, 3116, 3125, 3129, 3138, 3228, 3761, 3768, 4179, 4183], 'B': [2636, 3114, 3130, 3140, 3229, 3762, 4180], 'pre-Golgi': [2637, 2807, 3440, 3550, 3902, 4203], '∼170–190-kDa': [2640], 'glycosylated': [2642], 'C': [2644, 2694, 2762, 3117, 3126, 3769, 4184], 'diagnostic': [2646], 'Golgi-associated': [2650], 'mannosidases': [2651], 'glycosyltransferases': [2653], 'polylactosamine': [2659], "(31.O'Riordan": [2660], 'Lachapelle': [2662], 'Higgins': [2666], 'E.A.': [2667], 'Cheng': [2668], 'Glycobiology.': [2670], '10:': [2672, 3600, 3960], '1225-1233Crossref': [2673], '(28)': [2676], '(Fig.': [2679, 2770, 2989, 3054, 3082, 3210, 3237, 3702, 3776, 4162, 4191], 'A–C).': [2681, 3778, 4193], 'In': [2682, 4168], 'control': [2683, 3148, 3897, 4274], '∼30%': [2685], 'processed': [2689], 'mature': [2692, 3159, 3174], 'glycoisoform': [2695, 2763, 2814, 3160, 3175, 4112, 4185], 'h,': [2698], 'efficiency': [2702, 3107], 'rate': [2704, 3233, 3758, 3765], 'stably': [2711], 'transfected': [2712], 'lines': [2714], 'Scholar,13.Ward': [2736], 'contrast,': [2753, 4169], 'no': [2754, 3754], 'observed': [2765], 'Sar1-GTP(H79G)': [2769, 2784, 2987, 3203, 3221, 3224], '1B).': [2771], 'As': [2772], 'control,': [2774], 'under': [2775, 3675], 'identical': [2776], 'also': [2779], 'tested': [2780], 'effect': [2782, 3755], 'reporter': [2790], 'type': [2792], 'glycoprotein': [2799], '(endo': [2805], 'H)-sensitive': [2806], 'endo': [2811, 3699, 4108, 4165], 'H-resistant,': [2812], 'Golgi-processed': [2813], 'Consistent': [2860, 3006], 'findings': [2863], 'Scholar,30.Aridor': [2894], '32.Aridor': [2913, 3328], '275:': [2921, 3336], '35673-35676Abstract': [2922, 3337], '(104)': [2930, 3345], '33.Aridor': [2933, 3348], 'Weissman': [2939, 2960, 3354, 3375], 'Roberts': [2941, 3356], 'T.H.': [2942, 3357], 'Lippincott-Schwartz': [2943, 3358], '2001;': [2950, 3365, 3853, 4258, 4328, 4356], '152:': [2951, 3366], '213-229Crossref': [2952, 3367], '(206)': [2955, 3370], '34.Aridor': [2958, 3373], 'Nouffer': [2964, 3379], '141:': [2972, 3387], '61-70Crossref': [2973, 3388], '(249)': [2976, 3391], 'inhibited': [2984], '1D).': [2990], 'Thus,': [2991, 3779, 4194], 'like': [2998], 'VSV-G,': [2999], 'dependent': [3001], 'COPII-mediated': [3004], 'mechanism.': [3005], 'interpretation,': [3009], 'analyses': [3011], 'high': [3018], 'resolution': [3019], 'deconvolution': [3020], 'microscopy': [3021], 'showed': [3022], 'significant': [3024], 'co-localization': [3025], '(∼70%': [3033], 'punctate': [3037, 3050, 3075], 'structures)': [3038, 3053, 3081], 'Sec23': [3041, 3051, 3079], '(∼40%': [3048], '1E)': [3055, 3083], 'significantly': [3058], 'cannot': [3067], 'exit': [3068], '(∼15%': [3071], 'structures;': [3076], '<10%': [3077], '(35.Riordan': [3084], 'Hum.': [3088], 'Genet.': [3089], '64:': [3091], '1499-1504Abstract': [3092], '(94)': [3100], 'express': [3105], 'glycisoforms,': [3118], 'compared': [3120], 'ratio': [3122, 3142, 3167, 3193, 3207, 3775, 4190], 'time.': [3135], 'If': [3136, 3164], 'C/band': [3139], '(C/B)': [3141], 'remains': [3143, 3519], 'unaltered': [3144], 'relative': [3145], 'co-expression': [3150], 'mutants,': [3154], 'affected.': [3163], 'C/B': [3166, 3192, 3206, 3774, 4189], 'reduced,': [3169], 'inhibited.': [3177], 'method,': [3181], 'alone': [3189], 'exhibited': [3190], '∼6': [3195], '3-h': [3198], 'period,': [3200], 'co-transfection': [3201], 'yielded': [3204], '∼0.1': [3209], '1C).': [3211], 'Interestingly,': [3212], 'stabilized': [3225], 'immature': [3226], '∼3–6-fold': [3236], '1A).': [3238], 'accepted': [3248], 'view': [3249], '36.Aridor': [3394], '274:': [3406], '4389-4399Abstract': [3407], '(92)': [3415], 'requires': [3426], 'function(s)': [3428], 'recruited': [3438], 'consisting': [3442], 'clusters': [3446], '(VTCs)': [3447], 'potentially': [3471], 'formed': [3472], 'vesicles': [3478, 4391], '(37.Rowe': [3479, 4217, 4287], '279:': [3491, 4229, 4299], '696-700Crossref': [3492, 4230, 4300], '(98)': [3495, 4233, 4303], 'COPI': [3498, 3516, 3521, 3617, 3647], 'include': [3500], 'Arf1': [3506, 3791], 'coatomer': [3509, 3681], 'complex.': [3511], 'controversial.': [3520], 'regulate': [3525], 'anterograde': [3526, 3793, 3879, 4208], 'VTCs': [3529], 'stack,': [3536, 3541], 'within': [3538], 'retrograde': [3544, 3796, 3898, 4210], 'membranes': [3553, 3686], '(27.Scales': [3557], '38.Pelham': [3572], 'H.R.': [3573], '102:': [3578], '713-719Abstract': [3579], '(196)': [3587], '39.Storrie': [3590], 'Pepperkok': [3592], 'Nilsson': [3594], 'Trends': [3596], '385-391Abstract': [3601], 'requirement': [3615, 4010], 'Arf1-GTP(Q71L),': [3627], 'blocking': [3646], 'disassembly': [3649], '(24.Dascher': [3650, 3707], 'Control': [3666, 4092], 'demonstrated': [3668, 4094], 'Arf1-GTP(Q71L)': [3671, 3749], 'these': [3676], 'stimulated': [3680], '(β-COP)': [3682], 'recruitment': [3683], 'completely': [3691], 'H-resistant': [3700, 4109], '2D)': [3703], '40.Zhang': [3723], 'Rosenwald': [3725], 'A.G.': [3726], 'Willingham': [3727], 'Skuntz': [3729], 'Clark': [3731], 'Kahn': [3733], 'R.A.': [3734], '124:': [3739], '289-300Crossref': [3740], '(154)': [3743], 'had': [3753], 'degradation,': [3763], '2,': [3777], 'Arf1-independent,': [3783], 'potential': [3788], 'perturbs': [3801], 'egress': [3802], 'Rab1': [3814, 3876, 4012], 'Rab2': [3816, 3892, 4014], 'members': [3818, 4339], 'ubiquitous': [3821], 'family': [3823, 4343], 'required': [3831, 4206, 4384], 'targeting': [3834], 'both': [3838, 3878], 'exocytic': [3840], 'endocytic': [3842], '(41.Zerial': [3844], 'McBride': [3846], 'Nat.': [3848, 4351], 'Mol.': [3850, 3956, 4353], '2:': [3854, 4259, 4329, 4357], '107-117Crossref': [3855], '(2760)': [3858], '42.Martinez': [3861], 'Goud': [3863], 'Biochim.': [3865], 'Biophys.': [3866], 'Acta.': [3867], '1404:': [3869], '101-112Crossref': [3870], '(230)': [3873], 'regulates': [3877], 'cis-Golgi': [3886], 'intra-Golgi': [3889], 'transport,': [3890], 'whereas': [3891], 'proposed': [3895], 'post-ER,': [3901], 'Scholar,43.Plutner': [3927], 'Cox': [3929], 'A.D.': [3930], 'Schwaninger': [3937], '1991;': [3946], '115:': [3947], '31-43Crossref': [3948], '(304)': [3951], '44.Tisdale': [3954], '1837-1849Crossref': [3961], '(67)': [3964], '45.Tisdale': [3967], '271:': [3975], '29372-29379Abstract': [3976], '(110)': [3984], '46.Tisdale': [3987], 'Jackson': [3989], 'M.R.': [3990], '273:': [3995], '17269-17277Abstract': [3996], '(45)': [4004], 'maturation,': [4018], 'Rab1a(N124I)': [4023], 'Rab2(N119I),': [4025], 'mutants': [4028, 4098], 'defective': [4031], 'guanine': [4033], 'nucleotide': [4034], 'binding': [4035], 'interfere': [4037, 4268], '47.Pind': [4067, 4137], 'S.N.': [4068, 4138], 'Davidson': [4075, 4145], 'H.W.': [4076, 4146], 'Farquhar': [4077, 4147], 'M.G.': [4078, 4148], '239-252Crossref': [4086, 4156], '(130)': [4089, 4159], 'functionally': [4100], '3D,': [4163], 'upper': [4164], 'Hr': [4166], 'bands).': [4167], 'Rab1(N124I)': [4171], 'Rab2(N119)': [4173], 'affected': [4174], '3,': [4192], 'controlling': [4199], '48.Allan': [4236, 4306], 'B.B.': [4237, 4254, 4307, 4324], '289:': [4244, 4314], '444-448Crossref': [4245, 4315], '(391)': [4248, 4318], '49.Moyer': [4251, 4321], 'Allan': [4253, 4323], '268-276Crossref': [4260, 4330], '(214)': [4263, 4333], 'did': [4266], 'assembly': [4276], 'targeting/fusion': [4279], 'includes': [4338], '(50.Chen': [4347], 'Y.A.': [4348], 'Scheller': [4349], 'R.H.': [4350], '98-106Crossref': [4358], '(896)': [4361], '51.Jahn': [4364], 'Sudhof': [4366], 'T.C.': [4367], 'Annu.': [4368], 'Biochem.': [4370], '68:': [4372], '863-911Crossref': [4373], '(1034)': [4376], 'Syntaxin': [4379], '(Syn5)': [4381], 'specifically': [4383], 'acceptor': [4393], 'Syn5': [4399], '(25.Dascher': [4407], '37.Row': [4425]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2012602248', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 17}], 'updated_date': '2024-12-11T02:19:07.577937', 'created_date': '2016-06-24'}
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