Publication Information

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['https://openalex.org/W4387235219', 'https://openalex.org/W3124513521', 'https://openalex.org/W2997694753', 'https://openalex.org/W2968257679', 'https://openalex.org/W2773563175', 'https://openalex.org/W2108980595', 'https://openalex.org/W2090751487', 'https://openalex.org/W2088104136', 'https://openalex.org/W2043290373', 'https://openalex.org/W1998890104'], 'abstract_inverted_index': {'Inflammatory': [0, 164], 'processes': [1, 165], 'are': [2, 166, 586, 646, 786, 1022, 1218, 1292, 1544, 2774, 3325, 3333, 3377, 3436, 3455, 3750, 3806, 3833, 4079, 4090, 4101, 4124, 4130, 4213], 'accompanied': [3, 167], 'by': [4, 49, 100, 124, 168, 213, 264, 288, 388, 415, 598, 792, 1224, 1298, 1651, 1666, 2037, 2057, 2302, 2345, 2433, 2510, 2693, 3069, 3144, 3489, 4110, 4322, 4342], 'the': [5, 37, 44, 68, 101, 121, 125, 146, 152, 158, 169, 201, 208, 232, 265, 285, 289, 310, 316, 322, 393, 396, 401, 451, 514, 593, 658, 903, 907, 934, 944, 1123, 1126, 1133, 1140, 1149, 1152, 1413, 1453, 1456, 1461, 1502, 1519, 1528, 1539, 1551, 1583, 1602, 1637, 1652, 1657, 1667, 1683, 1794, 1800, 1821, 1823, 1832, 1877, 1912, 1946, 2002, 2019, 2099, 2134, 2218, 2221, 2385, 2405, 2429, 2435, 2487, 2603, 2629, 2635, 2661, 2689, 2822, 2838, 2842, 2863, 2870, 2873, 2924, 2938, 2948, 2958, 2968, 2983, 3004, 3009, 3019, 3096, 3120, 3130, 3168, 3182, 3193, 3211, 3219, 3277, 3290, 3322, 3328, 3336, 3386, 3393, 3402, 3405, 3412, 3420, 3459, 3467, 3470, 3490, 3556, 3565, 3573, 3579, 3608, 3615, 3626, 3633, 3641, 3665, 3672, 3717, 3721, 3736, 3740, 3744, 3753, 3773, 3782, 3793, 3800, 3811, 3815, 3823, 3837, 3840, 3860, 3978, 3994, 4038, 4042, 4046, 4049, 4053, 4057, 4102, 4117, 4143, 4169, 4173, 4190, 4237, 4244, 4249, 4255, 4259, 4270, 4274, 4277, 4289, 4328, 4343], 'posttranslational': [6, 170, 334], 'modification': [7, 24, 171, 188, 335, 741], 'of': [8, 39, 46, 135, 154, 172, 203, 210, 299, 318, 330, 395, 404, 408, 450, 517, 649, 657, 660, 902, 909, 1028, 1069, 1125, 1148, 1314, 1415, 1455, 1460, 1501, 1592, 1604, 1615, 1811, 1827, 1914, 2021, 2098, 2172, 2220, 2248, 2260, 2330, 2349, 2380, 2390, 2415, 2428, 2467, 2486, 2504, 2688, 2696, 2866, 3018, 3028, 3034, 3040, 3046, 3052, 3129, 3159, 3181, 3192, 3243, 3272, 3355, 3392, 3395, 3414, 3425, 3429, 3445, 3561, 3625, 3716, 3735, 3739, 3755, 3787, 3822, 3839, 3844, 3857, 3888, 3970, 3980, 3993, 4041, 4045, 4056, 4142, 4151, 4172, 4189, 4248, 4258, 4273, 4318, 4331], 'certain': [9, 173], 'arginine': [10, 40, 174, 204, 406, 1520, 2867], 'residues': [11, 175, 2868, 3981, 4301], 'within': [12, 67, 176, 231, 400, 747, 3614, 3772, 3859], 'proteins': [13, 177, 331, 501, 650], 'to': [14, 34, 41, 160, 178, 198, 205, 324, 446, 588, 1041, 1131, 1509, 1534, 1599, 1613, 1648, 1685, 1910, 1916, 2030, 2040, 2321, 2397, 2923, 2937, 2947, 2957, 2967, 2982, 3003, 3095, 3167, 3241, 3255, 3351, 3379, 3640, 3671, 3728, 3814, 3998, 4063, 4149, 4177, 4299], 'yield': [15, 179], 'citrulline,': [16, 180], 'although': [17, 181], 'it': [18, 182, 521, 3769, 4242], 'is': [19, 98, 183, 262, 332, 386, 651, 804, 810, 938, 952, 959, 1039, 1120, 1412, 1421, 1433, 1507, 1645, 1660, 2877, 3008, 3119, 3343, 3409, 3483, 3612, 3638, 3770, 4135, 4243, 4320], 'largely': [20, 184], 'unknown': [21, 185], 'how': [22, 186, 1687], 'this': [23, 187, 739, 2857, 3464, 4332], 'influences': [25, 189, 337], 'antigen': [26, 54, 190, 218, 1950], 'presentation.': [27, 191], 'We': [28, 192, 1581], 'employed': [29, 193, 1582, 1909, 2847], 'crystallographic': [30, 194, 1226], 'and': [31, 59, 149, 195, 223, 313, 340, 391, 455, 592, 1035, 1136, 1217, 1300, 1527, 1586, 1588, 1619, 1696, 1725, 1797, 1803, 1841, 1903, 2009, 2049, 2096, 2117, 2120, 2128, 2178, 2187, 2210, 2306, 2365, 2377, 2383, 2403, 2426, 2444, 2473, 2493, 2506, 2522, 2628, 2701, 2726, 2764, 2771, 2794, 2815, 2831, 2850, 2852, 2894, 3164, 3170, 3184, 3195, 3205, 3239, 3247, 3254, 3259, 3331, 3366, 3397, 3427, 3451, 3463, 3475, 3477, 3535, 3546, 3586, 3596, 3618, 3651, 3660, 3685, 3779, 3791, 3804, 3819, 3849, 3985, 4034, 4052, 4073, 4082, 4084, 4099, 4122, 4126, 4128, 4195, 4199, 4227, 4310, 4334], 'functional': [32, 196, 1672], 'studies': [33, 197, 1673], 'investigate': [35, 199, 1600], 'whether': [36, 200, 1601, 1620], 'exchange': [38, 202], 'citrulline': [42, 206, 1606, 2839], 'affects': [43, 207], 'display': [45, 209], 'a': [47, 90, 129, 211, 254, 293, 333, 443, 653, 665, 805, 899, 1029, 1036, 1082, 1416, 1436, 1471, 1515, 1589, 1605, 1609, 1642, 1697, 1730, 2038, 2412, 2465, 2860, 3154, 3176, 3330, 3498, 3606, 3620, 3733, 3759, 4200], 'peptide': [48, 69, 127, 212, 233, 291, 564, 1037, 1127, 1141, 1426, 1457, 1523, 1553, 1610, 1659, 1698, 2022, 2107, 2222, 2605, 2630, 3160, 3280, 3408, 3471, 3723, 3742, 3784, 3824, 4105, 4144, 4175, 4260, 4275], 'two': [50, 102, 214, 266, 1630, 1668, 1712, 1836, 2874, 3274, 3356, 3491, 3718, 3745, 3812, 4047, 4180, 4278], 'human': [51, 215, 540], 'major': [52, 216, 527, 536, 541], 'histocompatibility': [53, 217, 528, 537, 542], 'class': [55, 219, 582, 3222], 'I': [56, 220, 3223], 'subtypes,': [57, 221], 'HLA-B*2705': [58, 222, 947], 'HLA-B*2709.': [60, 224], 'Both': [61, 225, 1020, 1542, 3216], 'differ': [62, 111, 226, 275, 4065], 'only': [63, 113, 227, 277, 1081, 3371, 4154], 'in': [64, 105, 128, 228, 269, 292, 513, 642, 795, 893, 906, 950, 957, 1080, 1138, 1159, 1294, 1435, 1470, 1505, 1512, 1538, 1546, 1550, 1624, 1641, 1662, 1729, 1773, 1779, 2006, 2018, 2125, 2183, 2195, 2217, 2308, 2555, 2660, 2776, 2821, 2841, 2920, 2934, 2944, 2954, 2964, 2979, 3000, 3092, 3153, 3175, 3187, 3210, 3289, 3339, 3349, 3374, 3418, 3432, 3449, 3453, 3458, 3485, 3495, 3497, 3540, 3553, 3578, 3591, 3603, 3636, 3648, 3675, 3743, 3763, 3766, 3789, 3810, 3836, 3991, 4030, 4067, 4093, 4145, 4254, 4261, 4276, 4283], 'residue': [65, 229, 407, 452, 1119, 1521, 1531, 4251, 4333], '116': [66, 230], 'binding': [70, 109, 234, 273, 1128, 1464, 1473, 1554, 1617, 1639, 1913, 3576, 3616, 3643, 3774, 3785, 3825, 4271, 4291], 'groove': [71, 235, 1555, 3617, 3775, 3826], 'despite': [72, 236, 3411], 'their': [73, 237, 4068], 'differential': [74, 133, 238, 297, 4039], 'association': [75, 239, 659, 935], 'with': [76, 140, 240, 304, 664, 752, 797, 814, 936, 1452, 1671, 1715, 1949, 1986, 2045, 2263, 2387, 2411, 2438, 2471, 2475, 2664, 2699, 2704, 2747, 2767, 2862, 3189, 3198, 3276, 3401, 3434, 3439, 3555, 3623, 3720, 3752, 4032, 4187, 4293], 'ankylosing': [77, 241, 545, 798], 'spondylitis,': [78, 242], 'an': [79, 243, 405, 409, 416, 755, 1625, 2063, 3389, 3541, 3884, 4323], 'inflammatory': [80, 244, 341, 644, 807], 'rheumatic': [81, 245], 'disorder.': [82, 246], 'The': [83, 132, 247, 296, 328, 448, 1076, 1145, 1629, 1788, 1829, 1992, 2025, 2298, 2502, 2779, 2812, 2834, 3423, 3714, 3854, 4140], 'crystal': [84, 248, 1631, 2399, 3357, 3375], 'structures': [85, 249, 1632, 2503, 3394, 3424, 3715, 3813, 3891], 'described': [86, 250, 1633, 1736, 2071, 2136], 'here': [87, 251, 1634, 2879], 'show': [88, 252, 1635], 'that': [89, 151, 253, 315, 336, 526, 809, 1038, 1510, 1636, 3370, 3748, 4235, 4268], 'modified': [91, 141, 255, 305, 1658], 'self-peptide,': [92, 256], 'pVIPR-U5': [93, 257, 1638, 1784, 2223, 3163, 3199, 3435, 3482, 3571, 3634, 3741, 3788, 4028], '(RRKWURWHL;': [94, 258], 'U': [95, 259, 1596], '=': [96, 260, 1597, 2972, 2987, 3101, 3107, 3245, 3249, 3257, 3261, 3658, 3662, 3683, 3687], 'citrulline),': [97, 261], 'presented': [99, 263, 597, 1040, 1293, 1661], 'HLA-B27': [103, 267, 815, 897, 904, 939, 1626, 1919, 2264, 3890, 4279], 'molecules': [104, 268, 1021, 1695, 2657], 'distinct': [106, 270], 'conformations.': [107, 271], 'These': [108, 272], 'modes': [110, 274, 3786, 4272], 'not': [112, 276, 464, 511, 960], 'drastically': [114, 278, 1295, 1663, 4066], 'from': [115, 120, 279, 284, 445, 750, 783, 1088, 1423, 1711, 1835, 2111, 2130, 3022, 3072, 3075, 3081, 3084, 3133, 3148, 3381, 3726, 4037, 4061], 'each': [116, 280], 'other': [117, 281, 1540, 3548, 3598, 4118], 'but': [118, 282, 463, 3013, 3124], 'also': [119, 283, 743, 1156, 2846, 3466, 3834, 4148], 'conformations': [122, 286, 1297, 1503, 1543, 1665, 3488, 3979], 'exhibited': [123, 287, 1650], 'non-citrullinated': [126, 290], 'given': [130, 294, 666, 1643, 2775, 2878], 'subtype.': [131, 295], 'reactivity': [134, 298], 'HLA-B27-restricted': [136, 300], 'cytotoxic': [137, 301, 556, 1676, 1719], 'T': [138, 302, 518, 557, 579, 584, 1677, 1702, 1720], 'cells': [139, 303, 585, 1043, 1708, 1769, 1815, 1993, 3324], 'or': [142, 306, 411, 1766, 1778, 1783, 1988, 2175, 2325, 3404, 4000], 'unmodified': [143, 307, 595, 1653, 3278, 3406, 3995], 'pVIPR': [144, 308, 569, 1469, 1593, 1654, 1782, 3165, 3279, 3407, 3647, 3669, 3996], 'supports': [145, 309], 'structural': [147, 311], 'findings': [148, 312], 'shows': [150, 314, 3747], 'presentation': [153, 317, 791], 'citrullinated': [155, 319, 500, 570, 591, 784, 1590, 2604, 3403, 3722, 4174, 4250], 'peptides': [156, 320, 596, 1150, 1915], 'has': [157, 321, 522, 742, 2253], 'potential': [159, 323, 459], 'influence': [161, 325], 'immune': [162, 326, 338], 'responses.': [163, 327, 1704], 'citrullination': [329, 648, 1688], 'responses': [339], 'reactions': [342], '(1.Ireland': [343, 601], 'J.': [344, 346, 349, 430, 488, 602, 604, 607, 629, 720, 850, 1010, 1108, 1170, 1175, 1244, 1278, 1335, 1360, 1385, 1394, 1489, 1570, 1752, 1967, 1973, 2154, 2282, 2541, 2715, 2736, 2753, 3310, 3520, 3703, 3916, 3944, 4016], 'Herzog': [345, 603], 'Unanue': [347, 605], 'E.R.': [348, 606, 695, 759], 'Immunol.': [350, 608, 630, 729, 882, 983, 1011, 1048, 1109, 1443, 1862, 1894, 1934, 2085, 3230, 3945], '2006;': [351, 377, 434, 492, 609, 686, 1397], '177:': [352, 610], '1421-1425Crossref': [353, 611], 'PubMed': [354, 380, 437, 495, 612, 634, 689, 712, 733, 776, 835, 855, 873, 887, 928, 974, 988, 1015, 1052, 1113, 1186, 1212, 1255, 1284, 1341, 1371, 1405, 1447, 1495, 1576, 1758, 1866, 1898, 1938, 1980, 2089, 2165, 2240, 2293, 2547, 2568, 2594, 2623, 2651, 2681, 2721, 2759, 2807, 3234, 3316, 3526, 3709, 3878, 3927, 3949, 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674], 'Löfberg': [366, 675], 'R.': [367, 676, 845, 865, 966, 1006, 1008, 1062, 1104, 1106, 1267, 1307, 1328, 1353, 1383, 1391, 1482, 1563, 1745, 2534, 3303, 3513, 3696, 3903, 3963, 4009], 'Ulfgren': [368, 677], 'A.K.': [369, 678], 'Klareskog': [370, 679], 'L.': [371, 680, 718, 724, 726, 841, 1204, 2480], 'Catrina': [372, 681], 'A.I.': [373, 682], 'Ann.': [374, 683], 'Rheum.': [375, 684, 708, 772], 'Dis.': [376, 685], '65:': [378, 687], '1219-1222Crossref': [379, 688], '(254)': [382, 691], 'Scholar).': [384, 638, 737, 891, 932, 1019, 1075, 1117, 1288, 1409, 1499, 1580, 1762, 1942, 2093, 2169, 2244, 2297, 2501, 2572, 2598, 2655, 2685, 2743, 2811, 3320, 3713, 4026], 'It': [385, 1432, 3493], 'catalyzed': [387], 'peptidylarginine': [389], 'deiminases': [390], 'involves': [392], 'replacement': [394, 2512], 'terminal': [397], 'imino': [398], 'group': [399, 418, 3204, 3214, 3295, 3341, 3384], 'side': [402, 453, 1143, 3559, 3610, 3842, 4054, 4106, 4329], 'chain': [403, 454, 1031, 3532, 3560, 3583, 3611, 3654, 3679, 3843, 4330], 'extra-': [410], 'intracellularly': [412], 'expressed': [413, 2123], 'protein': [414, 740, 905, 1078, 2381], 'amide': [417], '(3.György': [419], 'B.': [420, 478, 1060, 1064, 1243, 1275, 1305, 1309, 1334, 1359, 1381, 1393, 1488, 1569, 1751, 1892, 1932, 1969, 2083, 2153, 2281, 2540, 3309, 3519, 3702, 3913, 3961, 3965, 4015], 'Tóth': [421, 479], 'Tarcsa': [423, 481], 'Falus': [425, 483], 'A.': [426, 484, 622, 824, 863, 964, 1000, 1002, 1058, 1098, 1100, 1164, 1168, 1200, 1233, 1241, 1277, 1303, 1332, 1357, 1389, 1486, 1567, 1749, 1860, 1882, 1884, 1890, 1922, 1924, 1930, 1957, 1971, 1975, 2073, 2075, 2081, 2143, 2151, 2236, 2271, 2279, 2538, 2667, 3307, 3517, 3700, 3911, 3915, 3959, 4013], 'Buzás': [427, 485], 'E.I.': [428, 486], 'Int.': [429, 487], 'Biochem.': [431, 489], 'Cell': [432, 490], 'Biol.': [433, 491, 1176, 1245, 1280, 1361, 1395, 2155, 2283, 2755, 3917], '38:': [435, 493], '1662-1677Crossref': [436, 494], '(391)': [439, 497], 'Scholar),': [441, 499, 780, 1451, 2627, 3976], 'i.e.': [442], 'change': [444], '.': [447], 'length': [449, 3079], 'its': [456, 465, 1616], 'hydrogen': [457, 3621, 4185, 4205, 4216, 4297, 4325], 'bonding': [458], 'are,': [460], 'thus,': [461], 'retained': [462], 'positive': [466], 'charge.': [467], 'Although': [468, 3270], 'exceptions': [469], 'have': [470, 2818], 'been': [471, 524, 745, 2254, 2819, 3282], 'found': [472, 746, 1158, 2255, 3835, 3989], '(for': [473, 2352], 'review,': [474, 3955], 'see': [475, 3956], 'Ref.': [476, 3957], '3.György': [477], 'must': [502], 'usually': [503], 'be': [504, 1157], 'regarded': [505], 'as': [506, 508, 801, 1222, 1699, 1701, 1735, 1805, 1807, 2070, 2552, 3011, 3067, 3122, 3142, 3346, 3348, 3552, 3602, 3797, 3799, 4075, 4077, 4086, 4088, 4108, 4339, 4341], 'neoantigens': [507], 'they': [509, 3287, 3749], 'do': [510], 'participate': [512], 'thymic': [515], 'selection': [516], 'cells.': [519], 'Consequently,': [520], 'recently': [523], 'demonstrated': [525], 'complex': [529, 3433], '(MHC)': [530], '3The': [531], 'abbreviations': [532], 'used': [533, 2396, 2836], 'are:': [534], 'MHC,': [535], 'complex;': [538], 'HLA,': [539], 'antigen;': [543], 'AS,': [544], 'spondylitis;': [546], 'β2m,': [547], 'β2-microglobulin;': [548], 'B*2705,': [549, 4284], 'HLA-B*2705;': [550], 'B*2709,': [551, 1513, 2404, 3767, 3792], 'HLA-B*2709;': [552], 'Cir,': [553], 'citrulline;': [554], 'CTL,': [555], 'lymphocyte;': [558], 'HC,': [559], 'heavy': [560, 1030], 'chain;': [561], 'p1,': [562, 3983], 'p2,…,': [563], 'position': [565, 1524], '1,': [566, 3473, 3777, 3852], '2,…;': [567], 'pVIPR-U5,': [568], 'at': [571, 1122, 1522, 1999, 2015, 2192, 2249, 2452, 2458, 3251, 3263, 3544, 3594, 3982, 4252], 'p5;': [572], 'r.m.s.d.,': [573], 'root': [574, 3440], 'mean': [575, 3441], 'square': [576, 2409, 3442], 'deviation;': [577], 'TCR,': [578], 'cell': [580, 1024, 1703, 1917, 1953, 2903, 3208], 'receptor.': [581], 'II-restricted': [583], 'able': [587], 'distinguish': [589], 'between': [590, 1518, 1693, 2872, 3363, 4327, 4348], 'respective': [594, 3460], 'MHC': [599, 662, 793, 1694, 3221], 'antigens': [600, 794], '4.Hill': [617], 'J.A.': [618, 881, 916, 982, 1174, 1194], 'Southwood': [619], 'S.': [620, 2235, 2484], 'Sette': [621], 'Jevnikar': [623], 'A.M.': [624], 'Bell': [625], 'D.A.': [626, 820], 'Cairns': [627], '2003;': [631], '171:': [632], '538-541Crossref': [633], '(599)': [636], 'In': [639, 3569, 4116, 4162, 4210, 4240], 'autoimmune': [640], 'disorders,': [641], 'which': [643, 1420, 3419, 3757], 'lesions': [645], 'common,': [647], 'apparently': [652], 'general': [654], 'phenomenon,': [655], 'irrespective': [656], 'different': [661, 1296, 1535, 3291, 3415, 3487, 3783], 'genes': [663], 'disease': [667], '(2.Makrygiannakis': [668], '5.Vossenaar': [694], 'Smeets': [696, 760], 'T.J.M.': [697, 761], 'Kraan': [698, 762], 'M.C.': [699, 763], 'Raats': [700, 764], 'J.M.': [701, 765, 2735, 2752, 2801], 'van': [702, 766, 2613, 4229], 'Venrooij': [703, 767], 'W.J.': [704, 768], 'Tak': [705, 769], 'P.P.': [706, 770, 1004, 1102], 'Arthritis': [707, 771], '2004;': [709, 773, 1209, 1338, 1492, 1573, 1755, 2544, 2620, 2648, 3313, 3523, 3706, 3919, 4019], '50:': [710, 774, 2566], '3485-3494Crossref': [711, 775], '(227)': [714, 778], '6.Klareskog': [717], 'Rönnelid': [719], 'K.': [722, 1263, 1888, 1928, 2079, 2643, 3901], 'Padyukov': [723], 'Alfredsson': [725], 'Annu.': [727, 1046, 1441, 3228], 'Rev.': [728, 869, 970, 1047, 1442, 3229], '2008;': [730], '26:': [731, 2740], '651-675Crossref': [732], '(388)': [735], 'Because': [738], 'consistently': [744], 'synovial': [748], 'tissue': [749], 'patients': [751, 796, 1714], 'reactive': [753, 817], 'arthritis,': [754], 'HLA-B27-associated': [756], 'disorder': [757], '(5.Vossenaar': [758], 'fragments': [781], 'derived': [782, 1422], 'polypeptides': [785], 'most': [787, 4103], 'likely': [788], 'available': [789], 'for': [790, 896, 942, 1727, 1793, 1799, 1873, 1996, 2012, 2033, 2189, 2257, 2334, 2366, 2602, 2837, 3162, 3469, 3646, 3954], 'spondylitis': [799], '(AS)': [800], 'well.': [802], 'This': [803, 1118, 4315], 'chronic': [806], 'spondyloarthropathy': [808], 'even': [811], 'stronger': [812], 'associated': [813, 1948], 'than': [816, 1818, 3765, 4282], 'arthritis': [818], '(7.Brewerton': [819], 'Hart': [821], 'F.D.': [822], 'Nicholls': [823], 'Caffrey': [825], 'M.': [826, 994, 1092, 1162, 1166, 1198, 1202, 1206, 1229, 1235, 1261, 1322, 1351, 1476, 1557, 1739, 2139, 2145, 2267, 2273, 2528, 2669, 3297, 3507, 3690, 3899, 4003], 'James': [827], 'D.C.': [828, 2229, 3870], 'Sturrock': [829], 'R.D.': [830], 'Lancet.': [831], '1973;': [832, 852], '1:': [833], '904-907Abstract': [834], '(1489)': [837], '8.Schlosstein': [840], 'Terasaki': [842], 'P.I.': [843], 'Bluestone': [844], 'Pearson': [846], 'C.M.': [847], 'N.': [848, 867, 968, 2482], 'Engl.': [849], 'Med.': [851, 1337, 1491, 1572, 1754, 2543, 3312, 3522, 3705, 4018], '288:': [853], '704-706Crossref': [854], '(1088)': [857], '9.Khan': [860], 'M.A.': [861, 962], 'Mathieu': [862, 963, 999, 1097], 'Sorrentino': [864, 965, 1007, 1105, 1327, 1352, 1390, 1481, 1562, 1744, 2533, 3302, 3512, 3695, 4008], 'Akkoc': [866, 967], 'Autoimmun.': [868, 969], '2007;': [870, 884, 971, 985], '6:': [871, 972], '183-189Crossref': [872, 973], '(118)': [875, 976], '10.López': [878, 979], 'de': [879, 980, 1172, 1192], 'Castro': [880, 981, 1173, 1193], 'Lett.': [883, 984], '108:': [885, 986], '27-33Crossref': [886, 987], '(67)': [889, 990], 'Studies': [892], 'rats': [894], 'transgenic': [895], 'suggest': [898], 'direct': [900], 'involvement': [901], 'pathogenesis': [908], 'AS': [910, 937], '(11.Hammer': [911], 'R.E.': [912], 'Maika': [913], 'S.D.': [914], 'Richardson': [915], 'Tang': [917], 'J.P.': [918], 'Taurog': [919], 'J.D.': [920], 'Cell.': [921, 3871], '1990;': [922, 2718], '63:': [923, 1210], '1099-1112Abstract': [924], 'Full': [925, 1181, 1183, 1250, 1252, 1366, 1368, 1400, 1402, 2160, 2162, 2288, 2290, 3875, 3922, 3924], 'Text': [926, 1182, 1184, 1251, 1253, 1367, 1369, 1401, 1403, 2161, 2163, 2289, 2291, 3876, 3923, 3925], 'PDF': [927, 1185, 1254, 1370, 1404, 2164, 2292, 3877, 3926], '(857)': [930], 'Remarkably,': [933], 'allele': [940], '("subtype")-dependent;': [941], 'example,': [943], 'ubiquitous,': [945], 'frequent': [946], 'subtype': [948, 1463, 1644, 3581, 3674], '(B*2705': [949], 'short)': [951, 958], 'AS-associated,': [953], 'whereas': [954, 1466, 1514, 3335, 3664, 3977, 4133], 'HLA-B*2709': [955], '(B*2709': [956], '(9.Khan': [961], "12.D'Amato": [993], 'Fiorillo': [995, 1093, 1323, 1378, 1477, 1558, 1740, 2529, 3298, 3508, 3691, 4004], 'M.T.': [996, 1094, 1324, 1347, 1379, 1478, 1559, 1741, 2530, 3299, 3509, 3692, 4005], 'Carcassi': [997, 1095], 'C.': [998, 1066, 1096, 1311, 1349, 1377, 1858, 1886, 1926, 2077, 3909, 3967], 'Zuccarelli': [1001, 1099], 'Bitti': [1003, 1101], 'Tosi': [1005, 1103], 'Eur.': [1009, 1107, 3943], '1995;': [1012, 1049, 1110, 1444, 2804, 3231], '25:': [1013, 1111], '3199-3201Crossref': [1014, 1112], '(189)': [1017, 1115], 'heterotrimeric': [1023, 2261], 'surface': [1025], 'glycoproteins': [1026], 'consisting': [1027], '(HC),': [1032], 'β2-microglobulin': [1033], '(β2m),': [1034], 'effector': [1042], '(13.Madden': [1044, 1439, 3226], 'D.R.': [1045, 1440, 3227, 3864], '13:': [1050, 1445, 3232], '587-622Crossref': [1051, 1446, 3233], '(735)': [1054, 1449, 3236], '14.Ziegler': [1057, 3958], 'Loll': [1059, 1304, 1380, 3960], 'Misselwitz': [1061, 1266, 1306, 3902, 3962], 'Uchanska-Ziegler': [1063, 1242, 1274, 1308, 1333, 1358, 1392, 1487, 1568, 1750, 1891, 1931, 1968, 2082, 2152, 2280, 2539, 3308, 3518, 3701, 3912, 3964, 4014], 'López-Larrea': [1065, 1310, 3966], 'Molecular': [1067, 1312, 3968], 'Mechanisms': [1068, 1313, 3969], 'Spondyloarthropathies.': [1070, 1315, 3971], 'Landes': [1071, 1316, 3972], 'Bioscience,': [1072, 1317, 3973], 'Austin,': [1073, 1318, 3974], 'TX2008Google': [1074, 1319, 3975], 'B*2705': [1077, 1153, 1299, 1467, 1552, 1585, 1987, 2116, 2173, 2402, 3169, 3183, 3194, 3396, 3450, 3496, 3637, 3650, 3673, 3764, 3790, 3999, 4033, 4094, 4163], 'differs': [1079], 'single': [1083], 'HC': [1084, 1530, 2119, 2174, 2177, 2265, 3426, 3627, 4191, 4300], 'amino': [1085, 4059], 'acid': [1086], '(Asp-116)': [1087], 'B*2709': [1089, 1160, 1301, 1462, 1587, 1989, 2118, 2176, 3171, 3185, 3196, 3398, 3454, 3580, 3652, 4001, 4146, 4290], '(His-116)': [1090], "(12.D'Amato": [1091], 'located': [1121], 'floor': [1124], 'groove,': [1129, 1465, 4292], 'contributes': [1130], 'shaping': [1132], 'F': [1134, 3778], 'pocket,': [1135], 'participates': [1137], 'anchoring': [1139, 3856, 4040, 4247, 4317], 'C-terminal': [1142], 'chain.': [1144], 'vast': [1146], 'majority': [1147], 'constituting': [1151], 'repertoire': [1154], 'can': [1155, 1611, 1689], '(15.Ramos': [1161], 'Paradela': [1163, 1199], 'Vazquez': [1165, 1169], 'Marina': [1167], 'López': [1171], 'Chem.': [1177, 1246, 1362, 1396, 2156, 2284, 3918], '2002;': [1178, 1247, 2157, 2285], '277:': [1179, 1248, 2158, 2286], '28749-28756Abstract': [1180], '(80)': [1188, 1257, 2167, 2295], '16.López': [1191], 'Alvarez': [1195], 'I.': [1196, 1963], 'Marcilla': [1197], 'Ramos': [1201], 'Sesma': [1203], 'Vázquez': [1205], 'Tissue': [1207], 'Antigens.': [1208], '424-445Crossref': [1211], '(85)': [1214], 'Scholar)': [1216, 1984, 2551, 2725, 2763, 2793, 3238, 3882], 'presumably': [1219], 'displayed': [1220], 'similarly,': [1221], 'indicated': [1223, 4109], 'comparative': [1225], 'analyses': [1227], '(17.Hülsmeyer': [1228, 2138, 2266], 'Hillig': [1230, 2140, 2268], 'R.C.': [1231, 2141, 2269, 3897], 'Volz': [1232, 2142, 2270, 3910], 'Rühl': [1234, 2144, 2272], 'Schröder': [1236, 2146, 2274], 'W.': [1237, 1239, 1273, 1330, 1355, 1387, 1484, 1565, 1747, 2147, 2149, 2275, 2277, 2536, 3305, 3515, 3698, 3907, 4011], 'Saenger': [1238, 1272, 1329, 1354, 1386, 1483, 1564, 1746, 2148, 2276, 2535, 3304, 3514, 3697, 3906, 4010], 'Ziegler': [1240, 1276, 1331, 1356, 1388, 1485, 1566, 1748, 1889, 1929, 1970, 2080, 2150, 2278, 2537, 3306, 3516, 3699, 3914, 4012], '47844-47853Abstract': [1249, 2159, 2287], '18.Hülsmeyer': [1260], 'Welfle': [1262, 1270, 3900, 3904], 'Pöhlmann': [1264], 'T.': [1265, 1965], 'Alexiev': [1268], 'U.': [1269, 2234], 'H.': [1271, 3905], 'Mol.': [1279, 2716, 2754], '2005;': [1281, 1363, 3946], '346:': [1282], '1367-1379Crossref': [1283], '(46)': [1286], 'Some': [1289], 'peptides,': [1290, 4048], 'however,': [1291, 4120], '(14.Ziegler': [1302], '19.Hülsmeyer': [1321, 3506], 'Bettosini': [1325, 1479, 1560, 1742, 2531, 3300, 3510, 3693, 4006], 'F.': [1326, 1480, 1561, 1743, 2532, 3301, 3511, 3694, 4007], 'Exp.': [1336, 1490, 1571, 1753, 2542, 3311, 3521, 3704, 4017], '199:': [1339, 1493, 1574, 1756, 2545, 3314, 3524, 3707, 4020], '271-281Crossref': [1340, 1494, 1575, 1757, 2546, 3315, 3525, 3708, 4021], '(135)': [1343, 1497, 1578, 1760, 2549, 3318, 3528, 3711, 4024], '20.Fiorillo': [1346], 'Rückert': [1348], 'Hülsmeyer': [1350, 3898], '280:': [1364], '2962-2971Abstract': [1365], '(76)': [1373], '21.Rückert': [1376], 'Moretti': [1382], 'Biesiadka': [1384], '281:': [1398], '2306-2316Abstract': [1399], '(44)': [1407], 'Particularly': [1410], 'striking': [1411], 'case': [1414, 3468, 3838, 3992], 'self-peptide': [1417], '(pVIPR,': [1418], 'RRKWRRWHL),': [1419], 'vasoactive': [1424], 'intestinal': [1425], 'type': [1427], '1': [1428], 'receptor': [1429], '(residues': [1430], '400-408).': [1431], 'bound': [1434, 3166, 3484, 3670, 3807, 3997], 'canonical': [1437, 3642], 'conformation': [1438, 3501, 3543, 3593, 3635, 3677, 4257], 'middle': [1454, 4170], 'bulging': [1458], 'out': [1459], 'displays': [1468, 3572], 'dual': [1472], 'mode': [1474, 1618, 1640, 3577, 3644], '(19.Hülsmeyer': [1475, 1556, 1738, 2527, 3296, 3689, 4002], 'One': [1500], 'observed': [1504, 3645], 'B*2705·pVIPR': [1506, 2515], 'identical': [1508, 3831], 'seen': [1511], 'salt': [1516], 'bridge': [1517], '5': [1525, 2202, 3016, 3127], '(pArg5)': [1526], 'polymorphic': [1529], 'Asp-116': [1532, 3448], 'leads': [1533, 4147], 'HC-peptide': [1536], 'contacts': [1537, 4232], 'conformation.': [1541], 'present': [1545], 'approximately': [1547], 'equal': [1548], 'amounts': [1549], 'subtypes': [1584, 1920, 3172, 3197, 3275, 3431, 3719, 3746], 'version': [1591], '(pVIPR-U5;': [1594], 'RRKWURWHL,': [1595], 'citrulline)': [1598], 'introduction': [1603], '(pCir5)': [1607], 'into': [1608, 2634, 3385, 4288], 'lead': [1612], 'changes': [1614, 1622, 3373], 'these': [1621, 1944, 3273], 'occur': [1623], 'subtype-specific': [1627], 'manner.': [1628], 'diametrically': [1646], 'opposed': [1647], 'those': [1649, 3988], 'peptide.': [1655, 1828], 'Furthermore,': [1656, 4097], 'deviating': [1664], 'subtypes.': [1669, 3492, 4280], 'Combined': [1670], 'employing': [1674], 'pVIPR-specific': [1675, 1718], 'cells,': [1678], 'our': [1679], 'model': [1680, 2663], 'study': [1681], 'provides': [1682], 'basis': [1684], 'explain': [1686], 'affect': [1690], 'molecular': [1691, 2511, 3364], 'interactions': [1692], 'well': [1700, 1806, 3456, 3798, 4076, 4087, 4340], 'Cytotoxicity': [1705], 'Assays—Peripheral': [1706], 'blood': [1707], 'were': [1709, 1723, 1770, 1908, 1994, 2122, 2180, 2300, 2338, 2408, 2431, 2450, 2508, 2658, 2745, 2781], 'obtained': [1710, 1834, 2339, 2407, 3283], 'B*2705-positive': [1713], 'AS.': [1716], 'HLA-B27-restricted,': [1717], 'lymphocytes': [1721], '(CTLs)': [1722], 'generated': [1724, 2607, 2782], 'tested': [1726], 'specificity': [1728], 'standard': [1731], '4-h': [1732], 'cytotoxicity': [1733], 'assay': [1734], 'previously': [1737, 2137, 3502, 3990], 'Briefly,': [1763], '51Cr-labeled': [1764], 'T2-B*2705': [1765], 'T2-B*2709': [1767], 'target': [1768, 1814, 3073, 3082, 3149], 'either': [1771, 3400], 'incubated': [1772, 2011], 'medium': [1774, 1780, 1824], 'alone': [1775], '(negative': [1776], 'control)': [1777], 'containing': [1781], '(70': [1785], 'μm,': [1786], 'respectively).': [1787], 'effector/target': [1789], 'ratio': [1790], 'was': [1791, 1816, 1825, 1990, 2027, 2060, 2109, 2395, 2576, 2606, 2631, 2691, 2708, 2845, 3465], '12:1': [1792], 'MP2': [1795], 'CTL': [1796, 1801], '15:1': [1798], 'MP9': [1802], 'MP11': [1804], 'BO45.': [1808], 'Spontaneous': [1809], 'release': [1810], '51Cr-labeled,': [1812], 'washed': [1813], 'lower': [1817], '15%.': [1819], 'During': [1820], 'assay,': [1822], 'devoid': [1826], 'results': [1830], 'summarize': [1831], 'data': [1833, 2449, 3020, 3131], 'independent': [1837], 'experiments.': [1838], 'Monoclonal': [1839], 'Antibodies': [1840], 'Peptide': [1842], 'Binding': [1843], 'Assays—The': [1844], 'monoclonal': [1845, 2047], 'antibodies': [1846], 'ME1': [1847], '(anti-HLA-B27,': [1848], 'B7,': [1849], 'B22,': [1850], 'B73': [1851], 'HC·β2m': [1852], 'complexes;': [1853], 'IgG1': [1854], '(22.Ellis': [1855], 'S.A.': [1856], 'Taylor': [1857], 'McMichael': [1859, 3937], 'Hum.': [1861, 1893, 1933, 2084], '1982;': [1863], '5:': [1864], '49-59Crossref': [1865], '(210)': [1868], 'Scholar)),': [1870, 1902], 'MARB3': [1871], '(specific': [1872], 'HC·β2m-peptide': [1874], 'complexes': [1875, 2262, 2299, 2332, 2430, 3191, 3217, 3421], 'carrying': [1876], 'HLA-Bw4': [1878], 'determinant;': [1879], 'IgM': [1880], '(23.Rehm': [1881, 1921, 2072], 'Rohr': [1883, 1923, 2074], 'Seitz': [1885, 1925, 2076], 'Wonigeit': [1887, 1927, 2078], '2000;': [1895, 1935, 2086], '61:': [1896, 1936, 2087], '408-418Crossref': [1897, 1937, 2088], '(12)': [1900, 1940, 2091], 'appropriate': [1904, 2046], 'negative': [1905], 'isotype': [1906], 'controls': [1907], 'assess': [1911], 'surface-expressed': [1918], 'For': [1943, 2401], 'tests,': [1945], 'transporter': [1947], 'processing': [1951], '2-negative': [1952], 'line': [1954], 'BM36.1': [1955], '(24.Kelly': [1956], 'Powis': [1958], 'S.H.': [1959], 'Kerr': [1960], 'L.-A.': [1961], 'Mockridge': [1962], 'Elliott': [1964], 'Bastin': [1966], 'Trowsdale': [1972], 'Townsend': [1974], 'Nature.': [1976], '1992;': [1977, 2237, 3872], '355:': [1978], '641-644Crossref': [1979], '(378)': [1982], 'transfected': [1985], 'employed.': [1991], 'preincubated': [1995], '36': [1997], 'h': [1998, 2005, 2014, 2035], '26': [2000, 2016], '°C,': [2001], 'last': [2003], '12': [2004], 'serum-free': [2007], 'medium,': [2008], 'then': [2010, 2028, 2181], '20': [2013], '°C': [2017, 2032, 2042, 2194], 'presence': [2020, 2219, 3413], '(50': [2023], 'μm).': [2024], 'temperature': [2026], 'elevated': [2029, 4111], '37': [2031], '4': [2034, 2041, 2193], 'followed': [2036], 'decrease': [2039], 'before': [2043], 'incubation': [2044], 'reagents': [2048], 'Alexa-labeled': [2050], 'goat': [2051], 'anti-mouse': [2052], 'IgG.': [2053], 'Single': [2054], 'color': [2055], 'analysis': [2056], 'flow': [2058], 'cytometry': [2059], 'done': [2061], 'on': [2062, 2455, 3015, 3065, 3126, 3140], 'EPICS-XL': [2064], 'instrument': [2065], '(Coulter,': [2066], 'Miami,': [2067], 'FL)': [2068], 'essentially': [2069], 'Expression,': [2094], 'Purification,': [2095], 'Crystallization': [2097], 'HLA-B27·pVIPR-U5': [2100, 2331], 'Complexes—The': [2101], 'high': [2102], 'performance': [2103], 'liquid': [2104], 'chromatography-purified,': [2105], 'citrulline-modified': [2106], '(pVIPR-U5)': [2108], 'purchased': [2110], 'Alta': [2112], 'Bioscience': [2113], '(Birmingham,': [2114], 'UK).': [2115], 'β2m': [2121, 2179, 3428], 'separately': [2124], 'Escherichia': [2126], 'coli': [2127], 'purified': [2129, 2301], 'inclusion': [2131], 'bodies': [2132, 2171], 'following': [2133], 'protocol': [2135], 'Inclusion': [2170], 'dissolved': [2182], '50%': [2184], '(w/v)': [2185], 'urea': [2186], 'refolded': [2188], '2-3': [2190], 'weeks': [2191, 2252], '400': [2196, 2442], 'mm': [2197, 2200, 2203, 2207, 2212, 2312, 2315], 'l-arginine-HCl,': [2198], '2': [2199, 2251], 'EDTA,': [2201], 'reduced': [2204], 'glutathione,': [2205, 2209], '0.5': [2206], 'oxidized': [2208], '100': [2211, 2453], 'Tris': [2213, 2361, 2373], 'HCl,': [2214, 2362, 2374], 'pH': [2215, 2319, 2363, 2375], '7.5,': [2216, 2364], '(25.Garboczi': [2224], 'D.N.': [2225], 'Hung': [2226], 'D.T.': [2227], 'Wiley': [2228, 3869], 'Proc.': [2230], 'Natl.': [2231], 'Acad.': [2232], 'Sci.': [2233], '89:': [2238], '3429-3433Crossref': [2239], '(579)': [2242], 'A': [2245, 2599, 3360, 3474], 'refolding': [2246], 'period': [2247], 'least': [2250], 'essential': [2256], 'efficient': [2258], 'formation': [2259], 'size': [2303, 2414], 'exclusion': [2304], 'chromatography': [2305], 'concentrated': [2307], 'TBS': [2309], 'buffer': [2310], '(20': [2311], 'Tris-HCl,': [2313], '150': [2314], 'NaCl,': [2316], '0.01%': [2317], 'NaN3,': [2318], '7.5)': [2320], '14.5': [2322], 'mg/ml': [2323, 2327], '(B*2705·pVIPR-U5)': [2324, 2443, 2830], '18': [2326], '(B*2709·pVIPR-U5).': [2328, 2447, 2833], 'Crystals': [2329], 'suitable': [2333], 'x-ray': [2335], 'diffraction': [2336], 'experiments': [2337], 'using': [2340, 2464, 2513, 2578, 2608, 2638, 2710, 2783], 'hanging': [2341], 'drop': [2342], 'vapor': [2343], 'diffusion': [2344], 'mixing': [2346], '1.8': [2347, 2378], 'μl': [2348, 2379, 2389], 'precipitant': [2350, 2391, 2436], 'solution': [2351, 2382, 2437], 'B*2705·pVIPR-U5,': [2353], '24%': [2354], 'polyethylene': [2355, 2440], 'glycol': [2356, 2441], '(PEG)': [2357], '8000,': [2358, 2370], '0.1': [2359, 2371], 'm': [2360, 2372], 'B*2709·pVIPR-U5,': [2367], '25%': [2368], 'PEG': [2369], '8.0)': [2376], 'equilibrating': [2384], 'droplets': [2386], '750': [2388], 'solution.': [2392], 'Streak': [2393], 'seeding': [2394], 'improve': [2398], 'growth.': [2400], 'crystals': [2406, 3271], 'plates': [2410], 'maximum': [2413], '45': [2416, 2418], '×': [2417, 2419], '15': [2420], 'μm.': [2421], 'Data': [2422, 2491, 2517, 2769, 2824], 'Collection,': [2423], 'Structure': [2424, 2706], 'Determination,': [2425], 'Refinement—Crystals': [2427], 'cryo-protected': [2432], 'supplementing': [2434], '30%': [2439], '20%': [2445], 'glycerol': [2446], 'X-ray': [2448], 'collected': [2451], 'K': [2454], 'station': [2456], 'ID29': [2457], 'European': [2459], 'Synchrotron': [2460], 'Radiation': [2461], 'Facility,': [2462], 'Grenoble': [2463], 'wavelength': [2466], '0.982': [2468], 'Å,': [2469], 'processed': [2470], 'DENZO,': [2472], 'scaled': [2474], 'SCALEPACK': [2476], '(26.Otwinowski': [2477], 'Z.': [2478], 'Sawyer': [2479], 'Isaacs': [2481], 'Bailey': [2483], 'Proceedings': [2485], 'CCP4': [2488], 'Study': [2489], 'Weekend:': [2490], 'Collection': [2492], 'Processing.': [2494], 'SERC': [2495], 'Daresbury': [2496], 'Laboratory,': [2497], 'Warrington,': [2498], 'UK1993:': [2499], '56-62Google': [2500], 'B*2705·pVIPR-U5': [2505], 'B*2709·pVIPR-U5': [2507, 3666, 4262], 'determined': [2509], 'peptide-stripped': [2514], '(Protein': [2516], 'Bank': [2518, 2825], '(PDB)': [2519], 'code': [2520, 2525], '1OGT)': [2521], 'B*2709·pVIPR': [2523], '(PDB': [2524], '1OF2)': [2526], 'search': [2553], 'models': [2554], 'program': [2556, 2579], 'MOLREP': [2557], '(27.Collaborative': [2558], 'Computational': [2559], 'Project': [2560], '4Acta': [2561], 'Crystallogr.': [2562, 2588, 2617, 2645, 2675, 2738], 'Sect.': [2563, 2589, 2618, 2646, 2676], '1994;': [2565, 2756], '760-763Crossref': [2567], '(19876)': [2570], 'Restrained': [2573], 'maximum-likelihood': [2574, 2702], 'refinement': [2575, 2703, 2772, 2895], 'performed': [2577, 2709], 'REFMAC5': [2580], '(28.Murshudov': [2581], 'G.N.': [2582], 'Vagin': [2583], 'A.A.': [2584], 'Dodson': [2585], 'E.J.': [2586], 'Acta': [2587, 2616, 2644, 2674], '1997;': [2591], '53:': [2592], '240-255Crossref': [2593], '(14022)': [2596], 'topography': [2600], 'file': [2601], 'PRODRG': [2609], 'server': [2610], '(29.Schuttelkopf': [2611], 'A.W.': [2612], 'Aalten': [2614], 'D.M.': [2615], '60:': [2621, 2649], '1355-1363Crossref': [2622], '(4496)': [2625], 'placed': [2632], 'manually': [2633, 2766], 'electron': [2636, 3461], 'density': [2637], 'COOT': [2639, 2700], '(30.Emsley': [2640], 'P.': [2641, 3942], 'Cowtan': [2642], '2126-2132Crossref': [2650], '(24308)': [2653], 'Water': [2656], 'included': [2659], 'initial': [2662], 'ARP/wARP': [2665], '(31.Perrakis': [2666], 'Harkiolaki': [2668], 'Wilson': [2670], 'K.S.': [2671, 3936], 'Lamzin': [2672], 'V.S.': [2673], '2001;': [2678], '57:': [2679], '1445-1450Crossref': [2680], '(462)': [2683], 'Further': [2686], 'improvement': [2687], 'structure': [2690, 2816, 3667], 'achieved': [2692], 'iterative': [2694], 'cycles': [2695], 'manual': [2697], 'rebuilding': [2698], 'REFMAC5.': [2705], 'validation': [2707], 'programs': [2711], 'WHATIF': [2712], '(32.Vriend': [2713], 'G.': [2714], 'Graph.': [2717], '8:': [2719, 2805], '52-56Crossref': [2720], '(3396)': [2723], 'PRO-CHECK': [2727], '(33.Laskowski': [2728], 'R.A.': [2729, 2799], 'MacArthur': [2730], 'M.W.': [2731], 'Moss': [2732], 'D.S.': [2733], 'Thornton': [2734, 2751, 2800], 'Appl.': [2737], '1993;': [2739], '283-291Crossref': [2741], 'Angles': [2744], 'calculated': [2746, 3014, 3068, 3125, 3143], 'HBPLUS': [2748], '(34.McDonald': [2749], 'I.K.': [2750], '238:': [2757], '777-793Crossref': [2758], '(1903)': [2761], 'checked': [2765], 'COOT.': [2768], 'collection': [2770, 2893], 'statistics': [2773], 'Table': [2777, 2853, 3630, 4167, 4266], '1.': [2778], 'figures': [2780], 'PYMOL': [2784], '(35.DeLano': [2785], 'W.L.': [2786], 'PYMOL.': [2787], 'DeLano': [2788], 'Scientific,': [2789], 'Palo': [2790], 'Alto,': [2791], 'CA2002Google': [2792], 'LIGPLOT': [2795], '(36.Wallace': [2796], 'A.C.': [2797], 'Laskowski': [2798], 'Protein': [2802, 2823], 'Eng.': [2803], '127-134Crossref': [2806], '(4583)': [2809], 'atomic': [2813], 'coordinates': [2814], 'amplitudes': [2817], 'deposited': [2820], 'under': [2826, 2848, 3284], 'accession': [2827], 'codes': [2828], '3B6S': [2829], '3B3I': [2832], 'nomenclature': [2835, 2858], 'atoms': [2840, 2865], 'PDB': [2843], 'files': [2844], '"Results"': [2849], '"Discussion"': [2851], '2.': [2854], 'However,': [2855, 3481, 3732], 'because': [2856, 3327], 'makes': [2859], 'comparison': [2861, 3391, 3734], 'corresponding': [2864], 'difficult,': [2869], 'correspondence': [2871], 'atom': [2875], 'designations': [2876], '(citrulline-arginine):': [2880], 'O1-O,': [2881], 'C1-C,': [2882], 'C2-CA,': [2883], 'N2-N,': [2884], 'C3-CB,': [2885], 'C4-CG,': [2886], 'C5-CD,': [2887], 'N6-NE,': [2888], 'C7-CZ,': [2889], 'O7-NH2,': [2890], 'N8-NH1.TABLE': [2891], '1Data': [2892], 'statisticsB*2705': [2896], '·': [2897, 2899], 'pVIPR-U5B*2709': [2898], 'pVIR-U5Data': [2900], 'collectionSpace': [2901], 'groupP212121P212121Unit': [2902], 'a;': [2904], 'b;': [2905], 'c': [2906, 3338], '(Å)50.7;': [2907], '82.8;': [2908], '110.351.3;': [2909], '82.3;': [2910], '109.3α;': [2911], 'β;': [2912], 'γ': [2913], '°90.00;': [2914], '90.00;': [2915, 2917], '90.0090.00;': [2916], '90.00Resolution': [2918], '(Å)aValues': [2919], 'parentheses': [2921, 2935, 2945, 2955, 2965, 2980, 3001, 3093], 'refer': [2922, 2936, 2946, 2956, 2966, 2981, 3002, 3094], 'highest': [2925, 2939, 2949, 2959, 2969, 2984, 3005, 3097], 'resolution': [2926, 2940, 2950, 2960, 2970, 2985, 3006, 3098], 'shell.50.0-1.79': [2927], '(1.85-1.79)30.0-1.86': [2928], '(1.90-1.86)Unique': [2929], 'reflections39,485': [2930], '(2,492)35,295': [2931], '(2,463)Completeness': [2932], '(%)aValues': [2933], 'shell.94.72': [2941], '(82.3)93.13': [2942], '(89.9)RedundancyaValues': [2943], 'shell.4.2': [2951], '(4.0)3.1': [2952], '(2.9)I/ρaValues': [2953], 'shell.11.7': [2961], '(2.7)13.1': [2962], '(3.5)RsymaValues': [2963], 'shell.,bRsym': [2971], '∑h∑i': [2973, 3102], '|Ih,i': [2974, 3103], '−': [2975, 2990, 3104, 3110], '<Ih>|/∑h∑iIh,i.0.097': [2976], '(0.488)0.071': [2977], '(0.303)RefinementRcrystaValues': [2978], 'shell.,cRcryst': [2986], '∑h': [2988, 3108], '|Fo': [2989, 3109], 'Fc|/∑Fo': [2991, 3111], '(working': [2992, 3112], 'set,': [2993, 3113], 'no': [2994, 3114], 'ρ': [2995, 3115], 'cut-off': [2996, 3116], 'applied).0.184': [2997], '(0.242)0.189': [2998], '(0.227)RfreeaValues': [2999], 'shell.,dRfree': [3007], 'same': [3010, 3121], 'Rcryst': [3012, 3106, 3123, 3244, 3256], '%': [3017, 3128], 'excluded': [3021, 3132], 'refinement.0.224': [3023], '(0.273)0.233': [3024], '(0.291)Heavy': [3025], 'chain,': [3026], 'no.': [3027, 3033, 3039, 3045, 3051], 'atoms/average': [3029, 3035, 3041, 3053], 'B': [3030, 3036, 3042, 3048, 3054, 3737, 3861, 4112, 4158], 'factor': [3031, 3037, 3043, 3049, 3055], '(Å2)2278/11.82285/13.4β2m,': [3032], '(Å2)847/15.8855/17.9Peptide,': [3038], '(Å2)100/15.8100/17.3Water,': [3044], 'molecules/average': [3047], '(Å2)555/26.1428/28.0Glycerol,': [3050], '(Å2)036/38.2Estimated': [3056], 'overall': [3057, 3061, 3136], 'coordinate': [3058, 3062, 3137], 'error': [3059, 3063, 3138], '(Å)eEstimated': [3060], 'based': [3064, 3139], 'Rfree': [3066, 3118, 3141, 3248, 3260], 'Refmac': [3070, 3145], '5.1.1999.0.140.16r.m.s.d.fr.m.s.d.': [3071], 'geometries.': [3074, 3083, 3150], 'ideal': [3076, 3085], 'geometry,': [3077, 3086], 'bond': [3078, 3087, 3622, 4206, 4326], '[Å]0.0070.007r.m.s.d.fr.m.s.d.': [3080], 'angles': [3088, 3539, 3551, 3590, 3601, 3656, 3681, 4345], '[°]1.031.04PDB': [3089], 'code3B6S3B3Ia': [3090], 'Values': [3091], 'shell.b': [3099], 'Rsym': [3100], '<Ih>|/∑h∑iIh,i.c': [3105], 'applied).d': [3117], 'refinement.e': [3134], 'Estimated': [3135], '5.1.1999.f': [3146], 'r.m.s.d.': [3147], 'Open': [3151, 3173], 'table': [3152, 3174], 'new': [3155, 3177], 'tab': [3156, 3178], 'TABLE': [3157], '2Comparison': [3158], 'coordination': [3161], 'General': [3179], 'Features': [3180], 'Subtypes': [3186], 'Complex': [3188], 'pVIPR-U5—The': [3190], 'crystallized': [3200, 3288], 'isomorphously': [3201], '(same': [3202], 'space': [3203, 3213, 3294, 3340, 3383, 3416], 'comparable': [3206, 3326], 'unit': [3207, 3323], 'constants)': [3209], 'orthorhombic': [3212], 'P212121.': [3215], 'exhibit': [3218], 'typical': [3220], 'immunoglobulin-like': [3224], 'folds': [3225], 'refined': [3240], 'values': [3242, 4113, 4159], '18.4%': [3246], '22.4%': [3250], '1.79': [3252], 'Å': [3253, 3265], '18.9%': [3258], '23.3%': [3262], '1.86': [3264], 'resolution,': [3266], 'respectively': [3267], '(Table': [3268], '1).': [3269], 'had': [3281], 'similar': [3285, 3639], 'conditions,': [3286], 'monoclinic': [3292], 'P21': [3293, 3350], 'Nevertheless,': [3321], 'axes': [3329], 'b': [3332], 'isomorphous,': [3334], 'axis': [3337], 'P212121': [3342], 'almost': [3344], 'twice': [3345], 'long': [3347], 'accommodate': [3352], 'four': [3353], 'instead': [3354], 'asymmetric': [3358], 'units.': [3359], 'close': [3361], 'relation': [3362], 'packing': [3365, 3376], 'C2': [3367], 'symmetries': [3368], 'indicates': [3369], 'marginal': [3372], 'required': [3378], 'transform': [3380], 'one': [3382], 'other.': [3387], 'Therefore,': [3388, 3632], 'in-depth': [3390], 'complexed': [3399], 'justifiable': [3410], 'groups': [3417], 'crystallized.': [3422], 'both': [3430, 3649], 'nearly': [3437, 3808], 'identical,': [3438], 'deviations': [3443], '(r.m.s.d.)': [3444], '0.6': [3446], 'Å.': [3447], 'His-116': [3452, 3624, 4302], 'defined': [3457], 'densities,': [3462], '(Fig.': [3472, 3567, 3628, 3730, 3776, 4070, 4095, 4114, 4138, 4160], 'B,': [3476, 3817], 'supplemental': [3478], 'Fig.': [3479, 3828, 3851, 4165, 4264], 'S1).': [3480, 3829], 'grossly': [3486], 'occurs': [3494], 'canonical,': [3499], 'conventional': [3500], 'termed': [3503], '"p4α"': [3504], '(Ref.': [3505], 'Scholar;': [3530, 3953], 'main': [3531], 'φ': [3533, 3584, 3657, 3682], '(-84.7°)': [3534], 'ψ': [3536, 3587, 3661, 3686], '(-47.5°)': [3537], 'torsion': [3538, 3550, 3589, 3600, 3655, 3680], 'α-helical': [3542, 3592], 'p4,': [3545], 'all': [3547, 3597, 3889], 'φ/ψ': [3549, 3599], 'β-strands),': [3554], 'partially': [3557, 4091], 'solvent-exposed': [3558, 3841], 'pCir5': [3562, 3609, 4083, 4098, 4121, 4152, 4285, 4319], 'pointing': [3563], 'toward': [3564], 'α2-helix': [3566], '1C).': [3568, 4096], 'contrast,': [3570, 4241], 'non-canonical': [3574, 3676, 4256], '"p6α"': [3575], '(main': [3582, 3653, 3678], '(-121.7°)': [3585], '(27.0°)': [3588], 'p6,': [3595], 'β-strands).': [3604], 'As': [3605], 'consequence,': [3607], 'embedded': [3613], 'forms': [3619, 4179], '1D;': [3629], '2).': [3631], '-85.2°,': [3659], '-32.6°),': [3663], 'resembles': [3668], '-106.4°': [3684], '34.7°)': [3688], 'diverge': [3724], 'considerably': [3725], 'p3': [3727, 4062], 'p7': [3729, 4064], '1E).': [3731, 4071], 'factors': [3738], 'similar,': [3751], 'exception': [3754], 'pCir5,': [3756], 'exhibits': [3758], 'much': [3760], 'higher': [3761], 'flexibility': [3762], 'where': [3768], 'buried': [3771], 'G).': [3780], 'Despite': [3781], 'primary': [3794], 'anchor': [3795], 'pArg2': [3796, 3858], 'secondary': [3801], 'anchors': [3802], 'pArg1': [3803, 4072], 'pLeu9': [3805], 'identically': [3809], 'pockets': [3816], 'A,': [3818], 'F,': [3820], 'respectively,': [3821], '(supplemental': [3827, 3846, 4164, 4263], 'Virtually': [3830], 'orientations': [3832, 4069], 'pHis8': [3845, 4074], 'Figs.': [3847], 'S2': [3848], 'S3;': [3850, 4265], 'C-E).': [3853], 'firm': [3855, 4316], 'pocket': [3862], '(37.Madden': [3863], 'Gorga': [3865], 'J.C.': [3866], 'Strominger': [3867], 'J.L.': [3868], '70:': [3873], '1035-1048Abstract': [3874], '(614)': [3880], 'constitutes': [3883], 'highly': [3885, 4245], 'conserved': [3886], 'feature': [3887], 'solved': [3892], 'so': [3893], 'far': [3894], '(Refs.': [3895], '38.Hillig': [3896], 'Kozerski': [3908], '279:': [3920], '652-663Abstract': [3921], '(58)': [3929], '39.Stewart-Jones': [3932], 'G.B.': [3933], 'di': [3934], 'Gleria': [3935], 'A.J.': [3938], 'Jones': [3939], 'E.Y.': [3940], 'Bowness': [3941], '35:': [3947], '341-351Crossref': [3948], '(90)': [3951], 'p8,': [3984], 'p9': [3986], 'resemble': [3987], 'Conformation-dependent': [4027], 'Interactions': [4029], 'Complexes': [4031], 'B*2709—As': [4035], 'expected': [4036], 'central': [4043], 'portion': [4044, 4171], 'Cα': [4050], 'backbones': [4051], 'chains': [4055], 'intervening': [4058], 'acids': [4060], 'pTrp4': [4078, 4127], 'fully': [4080, 4131], 'solvent-accessible,': [4081], 'pArg6': [4085, 4100, 4129, 4155], 'pTrp7': [4089, 4123, 4335], 'solvent-accessible': [4092], 'flexible': [4104], 'chains,': [4107], '1F).': [4115], 'subtype,': [4119], 'buried,': [4125], 'solvent-exposed,': [4132], 'pLys3': [4134], 'partly': [4136], 'accessible': [4137], '1D).': [4139], 're-orientation': [4141], 'loss': [4150], 'flexibility;': [4153], 'retains': [4156], 'increased': [4157], '1G).': [4161], 'S2;': [4166], '2),': [4168], '(p3': [4176], 'p7)': [4178], 'very': [4181], 'short': [4182, 4294], '(2.7': [4183], 'Å)': [4184, 4204, 4296], 'bonds': [4186, 4217, 4298, 4347], 'Gln-155': [4188], '(pCir5N8': [4192, 4312], '→': [4193, 4197, 4208, 4219, 4222, 4225, 4304, 4308, 4313, 4337], 'Gln155O': [4194], 'pTrp7NE1': [4196], 'Gln155OE1)': [4198], 'further,': [4201], 'longer': [4202], '(3.1': [4203], '(pLys3N': [4207], 'Tyr99OH).': [4209], 'addition,': [4211], 'there': [4212], 'three': [4214], 'intrapeptide': [4215, 4324], '(pLys3O': [4218], 'pArg6NH2,': [4220], 'pLys3NZ': [4221], 'pCir5O1,': [4223], 'pTrp4O': [4224], 'pArg6NH2)': [4226], 'numerous': [4228], 'der': [4230], 'Waals': [4231], '(not': [4233], 'shown)': [4234], 'stabilize': [4236], 'whole': [4238], 'assembly.': [4239], 'characteristic': [4246], 'p5': [4253], '2)': [4267], 'distinguishes': [4269], 'Other': [4281], 'extends': [4286], 'deep': [4287], '(2.8-3.0': [4295], '(pCir5O7': [4303, 4307], 'His116NE2),': [4305], 'Lys-70': [4306], 'Lys70NZ),': [4309], 'Asp-77': [4311], 'Asp77OD2).': [4314], 'enforced': [4321], '(pCir5N6': [4336], 'pTrp7O)': [4338], 'favorable': [4344], 'involving': [4346], 'pCi': [4349]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2012542401', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-13T09:41:54.299781', 'created_date': '2016-06-24'}