Title: CHANGES IN INSULIN CONTENT OF, AND INSULIN AND RNA SYNTHESIS IN, ISOLATED RAT ISLETS OF LANGERHANS AFTER HYPOPHYSECTOMY AND SHORT-TERM GROWTH HORMONE REPLACEMENT
Abstract: Three to four weeks after hypophysectomy, the insulin content and glucose-stimulated insulin or total RNA synthesis in the pancreatic islets were estimated. The ratio of the glucose-stimulated insulin release to the islet insulin content was lowered. After short-term GH replacement, insulin release and insulin content were slightly increased such that the ratio of release to content remained virtually unaltered. Glucose-stimulated insulin synthesis was also depressed but improved slightly after GH replacement. However, there was no significant change in the incorporation of [5-3H]uridine into islet total RNA after hypophysectomy or subsequent GH replacement.
Publication Year: 1975
Publication Date: 1975-10-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 6
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