5-I A-85380 and TC-2559 differentially activate heterologously expressed α4β2 nicotinic receptors

Name: Work Video:
Duration: 3 min 30 s
Ruud Zwart; Lisa M. Broad; Qian Xi; Martin Lee; Mirko Moroni; Isabel Bermúdez; Emanuele Sher
{'id': 'https://openalex.org/W2012174837', 'doi': 'https://doi.org/10.1016/j.ejphar.2006.03.077', 'title': '5-I A-85380 and TC-2559 differentially activate heterologously expressed α4β2 nicotinic receptors', 'display_name': '5-I A-85380 and TC-2559 differentially activate heterologously expressed α4β2 nicotinic receptors', 'publication_year': 2006, 'publication_date': '2006-04-06', 'ids': {'openalex': 'https://openalex.org/W2012174837', 'doi': 'https://doi.org/10.1016/j.ejphar.2006.03.077', 'mag': '2012174837', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16674940'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ejphar.2006.03.077', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S187816532', 'display_name': 'European Journal of Pharmacology', 'issn_l': '0014-2999', 'issn': ['0014-2999', '1879-0712'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5030560026', 'display_name': 'Ruud Zwart', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210095227', 'display_name': 'Eli Lilly (United Kingdom)', 'ror': 'https://ror.org/00psab413', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I168537998', 'https://openalex.org/I4210095227']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Ruud Zwart', 'raw_affiliation_strings': ['Eli Lilly and Company Ltd., Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Eli Lilly and Company Ltd., Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom', 'institution_ids': ['https://openalex.org/I4210095227']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111962834', 'display_name': 'Lisa M. Broad', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210095227', 'display_name': 'Eli Lilly (United Kingdom)', 'ror': 'https://ror.org/00psab413', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I168537998', 'https://openalex.org/I4210095227']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Lisa M. Broad', 'raw_affiliation_strings': ['Eli Lilly and Company Ltd., Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Eli Lilly and Company Ltd., Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom', 'institution_ids': ['https://openalex.org/I4210095227']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037506999', 'display_name': 'Qian Xi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210095227', 'display_name': 'Eli Lilly (United Kingdom)', 'ror': 'https://ror.org/00psab413', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I168537998', 'https://openalex.org/I4210095227']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Qian Xi', 'raw_affiliation_strings': ['Eli Lilly and Company Ltd., Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Eli Lilly and Company Ltd., Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom', 'institution_ids': ['https://openalex.org/I4210095227']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101607401', 'display_name': 'Martin Lee', 'orcid': 'https://orcid.org/0000-0001-6529-5784'}, 'institutions': [{'id': 'https://openalex.org/I4210095227', 'display_name': 'Eli Lilly (United Kingdom)', 'ror': 'https://ror.org/00psab413', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I168537998', 'https://openalex.org/I4210095227']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Martin Lee', 'raw_affiliation_strings': ['Eli Lilly and Company Ltd., Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Eli Lilly and Company Ltd., Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom', 'institution_ids': ['https://openalex.org/I4210095227']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088361219', 'display_name': 'Mirko Moroni', 'orcid': 'https://orcid.org/0000-0002-2389-3468'}, 'institutions': [{'id': 'https://openalex.org/I124261462', 'display_name': 'Oxford Brookes University', 'ror': 'https://ror.org/04v2twj65', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124261462']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Mirko Moroni', 'raw_affiliation_strings': ['Department of Biological and Molecular Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological and Molecular Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, United Kingdom', 'institution_ids': ['https://openalex.org/I124261462']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008006905', 'display_name': 'Isabel Bermúdez', 'orcid': 'https://orcid.org/0000-0001-7692-1509'}, 'institutions': [{'id': 'https://openalex.org/I124261462', 'display_name': 'Oxford Brookes University', 'ror': 'https://ror.org/04v2twj65', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124261462']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Isabel Bermudez', 'raw_affiliation_strings': ['Department of Biological and Molecular Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological and Molecular Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, United Kingdom', 'institution_ids': ['https://openalex.org/I124261462']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5043250344', 'display_name': 'Emanuele Sher', 'orcid': 'https://orcid.org/0009-0000-5524-7375'}, 'institutions': [{'id': 'https://openalex.org/I4210095227', 'display_name': 'Eli Lilly (United Kingdom)', 'ror': 'https://ror.org/00psab413', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I168537998', 'https://openalex.org/I4210095227']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Emanuele Sher', 'raw_affiliation_strings': ['Eli Lilly and Company Ltd., Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Eli Lilly and Company Ltd., Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom', 'institution_ids': ['https://openalex.org/I4210095227']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2790, 'currency': 'USD', 'value_usd': 2790, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.745, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 40, 'citation_normalized_percentile': {'value': 0.839017, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '539', 'issue': '1-2', 'first_page': '10', 'last_page': '17'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11818', 'display_name': 'Nicotinic Acetylcholine Receptors Study', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11818', 'display_name': 'Nicotinic Acetylcholine Receptors Study', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12023', 'display_name': 'Cholinesterase and Neurodegenerative Diseases', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cys-loop-receptors', 'display_name': 'Cys-loop receptors', 'score': 0.54845905}], 'concepts': [{'id': 'https://openalex.org/C188987157', 'wikidata': 'https://www.wikidata.org/wiki/Q7030581', 'display_name': 'Nicotinic agonist', 'level': 3, 'score': 0.842744}, {'id': 'https://openalex.org/C80161118', 'wikidata': 'https://www.wikidata.org/wiki/Q408520', 'display_name': 'Acetylcholine receptor', 'level': 3, 'score': 0.7744876}, {'id': 'https://openalex.org/C2775910092', 'wikidata': 'https://www.wikidata.org/wiki/Q180623', 'display_name': 'Acetylcholine', 'level': 2, 'score': 0.7724874}, {'id': 'https://openalex.org/C2779570518', 'wikidata': 'https://www.wikidata.org/wiki/Q412256', 'display_name': 'Nicotinic acetylcholine receptor', 'level': 4, 'score': 0.6992115}, {'id': 'https://openalex.org/C45855136', 'wikidata': 'https://www.wikidata.org/wiki/Q4734890', 'display_name': 'Ganglion type nicotinic receptor', 'level': 5, 'score': 0.64237136}, {'id': 'https://openalex.org/C51927110', 'wikidata': 'https://www.wikidata.org/wiki/Q4734895', 'display_name': 'Alpha-4 beta-2 nicotinic receptor', 'level': 5, 'score': 0.5923981}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.5853551}, {'id': 'https://openalex.org/C19876734', 'wikidata': 'https://www.wikidata.org/wiki/Q5201170', 'display_name': 'Cys-loop receptors', 'level': 5, 'score': 0.54845905}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5043651}, {'id': 'https://openalex.org/C2779535977', 'wikidata': 'https://www.wikidata.org/wiki/Q1342298', 'display_name': 'Xenopus', 'level': 3, 'score': 0.45080394}, {'id': 'https://openalex.org/C64615621', 'wikidata': 'https://www.wikidata.org/wiki/Q15333405', 'display_name': 'Muscarinic acetylcholine receptor M5', 'level': 5, 'score': 0.4261679}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.41910735}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.35745624}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32687068}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.325624}, {'id': 'https://openalex.org/C116289061', 'wikidata': 'https://www.wikidata.org/wiki/Q17861955', 'display_name': 'Muscarinic acetylcholine receptor M3', 'level': 4, 'score': 0.22131816}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001384', 'descriptor_name': 'Azetidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D018722', 'descriptor_name': 'Nicotinic Agonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011978', 'descriptor_name': 'Receptors, Nicotinic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001384', 'descriptor_name': 'Azetidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018722', 'descriptor_name': 'Nicotinic Agonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018408', 'descriptor_name': 'Patch-Clamp Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011978', 'descriptor_name': 'Receptors, Nicotinic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011978', 'descriptor_name': 'Receptors, Nicotinic', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D014981', 'descriptor_name': 'Xenopus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ejphar.2006.03.077', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S187816532', 'display_name': 'European Journal of Pharmacology', 'issn_l': '0014-2999', 'issn': ['0014-2999', '1879-0712'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16674940', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1503583964', 'https://openalex.org/W1520253501', 'https://openalex.org/W1531561158', 'https://openalex.org/W1538286609', 'https://openalex.org/W1621382769', 'https://openalex.org/W1799536240', 'https://openalex.org/W1912293715', 'https://openalex.org/W1959145322', 'https://openalex.org/W1974789469', 'https://openalex.org/W1980333967', 'https://openalex.org/W1995625884', 'https://openalex.org/W2007226311', 'https://openalex.org/W2011620653', 'https://openalex.org/W2013341464', 'https://openalex.org/W2019931874', 'https://openalex.org/W2031173955', 'https://openalex.org/W2037097116', 'https://openalex.org/W2039975064', 'https://openalex.org/W2049084706', 'https://openalex.org/W2053266420', 'https://openalex.org/W2097682864', 'https://openalex.org/W2115872169', 'https://openalex.org/W2116249462', 'https://openalex.org/W2133636515', 'https://openalex.org/W2134231639', 'https://openalex.org/W2147835957', 'https://openalex.org/W2148168931', 'https://openalex.org/W2153609942', 'https://openalex.org/W2158847001', 'https://openalex.org/W2301755841', 'https://openalex.org/W2337485954', 'https://openalex.org/W2337946333', 'https://openalex.org/W4317639052'], 'related_works': ['https://openalex.org/W581368863', 'https://openalex.org/W3138944534', 'https://openalex.org/W2995069056', 'https://openalex.org/W2058252140', 'https://openalex.org/W2033865162', 'https://openalex.org/W2012174837', 'https://openalex.org/W1982848477', 'https://openalex.org/W1958451483', 'https://openalex.org/W1598732688', 'https://openalex.org/W1214975925'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2012174837', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 4}], 'updated_date': '2025-01-05T03:56:06.717940', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
