Publication Information

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[10, 254, 4516], 'for': [11, 27, 237, 255, 271, 481, 2354, 2440, 2701, 2755, 2836, 2926, 3040, 3742, 3798, 3991, 4517, 4672], 'recent': [13, 257, 2876], 'outbreak': [14, 258], 'of': [15, 43, 65, 93, 111, 132, 157, 172, 205, 214, 226, 240, 259, 287, 309, 337, 355, 376, 401, 416, 449, 458, 470, 484, 524, 1114, 1125, 1430, 1486, 1529, 1602, 1606, 1612, 1620, 1670, 1676, 1768, 1780, 1816, 1834, 1848, 2112, 2131, 2274, 2298, 2311, 2342, 2366, 2372, 2420, 2719, 2731, 2758, 2766, 2771, 2781, 2789, 2821, 2864, 2933, 2938, 2995, 3045, 3257, 3318, 3397, 3470, 3545, 3615, 3636, 3716, 3723, 3728, 3736, 3780, 3784, 3802, 3861, 3866, 3883, 4012, 4018, 4045, 4050, 4055, 4061, 4093, 4115, 4144, 4162, 4180, 4190, 4195, 4205, 4215, 4249, 4258, 4269, 4276, 4297, 4302, 4326, 4331, 4351, 4388, 4433, 4439, 4451, 4460, 4522, 4537, 4569, 4642, 4652, 4669, 4677, 4686, 4692, 4704, 4718, 4728], 'an': [16, 23, 143, 260, 267, 387, 1881, 3189, 3720, 4071], 'atypical': [17, 261, 525], 'pneumonia.': [18, 262], 'The': [19, 89, 113, 219, 263, 333, 357, 463, 1775, 2084, 2127, 2791, 2928, 2992, 3052, 3077, 3170, 3207, 3238, 3316, 3390, 3468, 3492, 3629, 3707, 3740, 3956, 4048, 4177, 4192, 4244, 4264, 4310, 4346, 4640], 'spike': [21, 99, 161, 265, 343, 405, 1492, 2086, 2133, 2346, 2422, 2742, 2774, 2806, 2846, 2866, 2935, 2997, 3987, 4034, 4228, 4237, 4564, 4572, 4644, 4654, 4688, 4705], 'protein,': [22, 266], 'enveloped': [24, 268], 'glycoprotein': [25, 269, 1494, 1611], 'essential': [26, 270], 'viral': [28, 68, 77, 87, 165, 181, 241, 272, 312, 321, 331, 409, 425, 485, 1595, 1671, 1733, 1818, 1828, 1841, 2095, 2269, 2441, 2759, 2801, 4029, 4105], 'entry,': [29, 273], 'belongs': [30, 274], 'to': [31, 57, 63, 202, 275, 301, 307, 446, 1123, 1142, 1527, 1754, 1771, 1813, 2262, 2292, 2370, 2433, 2750, 2786, 2797, 2946, 3027, 3119, 3234, 3254, 3712, 3765, 3972, 4022, 4394, 4556], 'the': [32, 41, 76, 104, 126, 130, 153, 203, 212, 224, 227, 238, 276, 285, 320, 348, 370, 374, 397, 447, 456, 468, 471, 482, 1126, 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2357, 2442, 2760, 2783, 2802, 2808, 2884, 2993, 3047, 3989, 4003, 4030, 4036, 4052, 4095, 4106, 4212, 4230, 4239, 4262, 4530, 4574, 4618, 4646, 4707], 'proteins': [36, 280, 1440, 1535, 1735, 1764, 1843], 'and': [37, 50, 78, 85, 103, 163, 281, 294, 322, 329, 347, 407, 1136, 1434, 1480, 1615, 1690, 1701, 1707, 1720, 1725, 1727, 1741, 1750, 1801, 1819, 1827, 1831, 2170, 2181, 2187, 2306, 2350, 2375, 2418, 2429, 2696, 2712, 2714, 2749, 2776, 2833, 2843, 2861, 2869, 2879, 2921, 2930, 2941, 2949, 3012, 3024, 3035, 3038, 3043, 3061, 3087, 3100, 3116, 3179, 3232, 3249, 3276, 3295, 3299, 3339, 3400, 3425, 3529, 3625, 3639, 3664, 3725, 3748, 3757, 3810, 3898, 3908, 3918, 3928, 3938, 3944, 3949, 3958, 3981, 4015, 4025, 4078, 4101, 4113, 4137, 4168, 4217, 4235, 4255, 4260, 4306, 4319, 4354, 4364, 4382, 4415, 4425, 4524, 4622, 4634, 4683, 4690, 4699, 4720, 4732], 'characterized': [39, 283, 1128, 1436, 2763, 2874], 'by': [40, 137, 183, 284, 381, 427, 597, 1437, 1490, 1759, 1823, 1876, 2255, 2290, 2875, 3008, 3081, 3091, 3134, 3140, 3323, 3395, 3474, 3550, 3634, 4066, 4159], 'presence': [42, 286], 'two': [44, 53, 288, 297, 1696, 1744, 1849, 2182, 2768, 4147, 4253, 4283, 4638], 'heptad': [45, 289, 507, 1745, 1850, 2183], 'repeat': [46, 290, 1746, 1851, 2184], '(HR)': [47, 291], 'regions,': [48, 292, 1747], 'HR1': [49, 140, 293, 384, 1749, 1800, 1868, 2417, 2711, 2929, 2948, 3011, 3034, 3897, 3907, 3917, 3927, 3937, 3948, 4063, 4083, 4116, 4166, 4206, 4254, 4300, 4328, 4363, 4370, 4682], 'HR2.': [51, 295, 1751], 'These': [52, 296, 2703, 4658], 'regions': [54, 298, 1852, 2185, 2709, 2770, 2863, 2872, 2932, 2951, 3735, 4257, 4301, 4381, 4429, 4685], 'are': [55, 299, 1421, 1435, 1488, 1658, 1665, 1679, 1693, 2260, 3750, 4117, 4430, 4464, 4515, 4544], 'understood': [56, 300], 'form': [58, 302, 523, 1804, 1853, 1870, 2424, 4126, 4146], 'fusion-active': [60, 304, 2313], 'conformation': [61, 305, 2796, 4521], 'similar': [62, 306, 1526, 2369, 2795, 2813, 4626], 'those': [64, 308, 2371, 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4684], 'helices': [123, 141, 367, 385, 1869, 1879, 4064, 4069, 4153, 4367, 4371, 4400, 4543], 'packed': [124, 368, 4545], 'against': [125, 369, 3107, 3152, 4155, 4546], 'hydrophobic': [127, 371, 1785, 2296, 4119, 4292, 4374, 4377, 4413, 4449, 4539], 'grooves': [128, 222, 372, 466, 2297, 4157, 4293, 4322, 4353, 4384, 4450], 'on': [129, 211, 223, 373, 455, 467, 1442, 1667, 2109, 3176, 3264, 4294, 4312, 4323, 4385], 'surface': [131, 225, 375, 469, 1444, 1669, 2111, 4286, 4296, 4325, 4387], 'central': [133, 228, 377, 472, 1872, 2299, 4164, 4299, 4327, 4390, 4453, 4548], 'coiled': [134, 229, 378, 473, 1873, 2300, 4059, 4329, 4391, 4454, 4549], 'coil': [135, 230, 379, 474, 1874, 2301, 4060, 4330], 'formed': [136, 380, 4158], 'parallel': [139, 383, 4057], 'in': [142, 192, 386, 436, 1703, 1709, 1715, 1722, 1729, 1787, 1865, 1880, 2251, 2286, 2302, 2358, 2818, 2952, 3068, 3072, 3181, 3245, 3345, 3733, 3752, 3762, 3813, 3863, 3868, 3878, 3896, 3900, 3906, 3910, 3916, 3920, 3926, 3930, 3936, 3940, 3947, 3951, 3966, 4070, 4082, 4098, 4110, 4124, 4233, 4242, 4281, 4336, 4379, 4396, 4401, 4408, 4427, 4472, 4533, 4541], 'oblique': [144, 388], 'antiparallel': [145, 389, 1883, 4073], 'manner.': [146, 390], 'shares': [149, 393, 2088], 'significant': [150, 394, 4714], 'similarity': [151, 395, 4635, 4715], 'mouse': [158, 402, 516], 'hepatitis': [159, 403, 517, 1517], 'proteins,': [167, 411, 1597, 2803, 4031, 4107, 4565], 'suggesting': [168, 412, 2810, 4701], 'conserved': [170, 414], 'mechanism': [171, 415, 1525], 'fusion.': [174, 418, 1774], 'Drug': [175, 419], 'discovery': [176, 420], 'strategies': [177, 421], 'aimed': [178, 422], 'inhibiting': [180, 424], 'entry': [182, 426], 'blocking': [184, 428, 2308], 'formation,': [186, 430], 'which': [187, 431, 1791, 1858, 1866, 2359, 3021, 4185, 4200, 4409], 'have': [188, 432, 2336, 2437, 3209], 'been': [189, 433, 1140, 4577], 'successfully': [190, 434], 'used': [191, 435, 495, 2817], 'human': [193, 437, 503, 1607], 'immunodeficiency': [194, 438, 504, 1608, 1717], '1': [196, 440, 1706], 'inhibitor': [197, 441], 'development,': [198, 442], 'may': [199, 443], 'be': [200, 232, 444, 476, 2816, 3129, 3964, 4661], 'applicable': [201, 445], 'inhibition': [204, 448, 2717], 'basis': [213, 457, 2754], 'structural': [215, 459, 1832, 2753, 2831, 4224], 'information': [216, 460, 2832], 'provided': [217, 461], 'here.': [218, 462], 'relatively': [220, 464, 4320], 'deep': [221, 465, 4318, 4340, 4344], 'will': [231, 475], 'good': [234, 478, 3125], 'target': [235, 479, 2834], 'site': [236, 480, 2835], 'design': [239, 483, 2757], 'inhibitors.': [243, 487], '(SARS)': [492], '1The': [493], 'abbreviations': [494], 'are:': [496], 'SARS,': [497], 'syndrome;': [501], 'HIV,': [502], 'virus;': [505], 'HR,': [506], 'repeat;': [508], 'SARS-CoV,': [509], 'coronavirus;': [514], 'MHV,': [515], 'virus.': [518], 'new': [521, 2953, 3880], 'life-threatening': [522], 'pneumonia': [526], '(1Tsang': [527], 'K.W.': [528], 'Mok': [529], 'T.Y.': [530], 'Wong': [531], 'P.C.': [532], 'Ooi': [533], 'G.C.': [534], 'Respirology.': [535], '2003;': [536, 588, 660, 701, 724, 788, 847, 893, 1025, 1104, 1183, 1206, 1333, 1412, 1585, 2152, 2238], '8:': [537], '259-265Crossref': [538], 'PubMed': [539, 591, 663, 704, 727, 791, 855, 901, 1028, 1107, 1186, 1209, 1336, 1415, 1458, 1471, 1505, 1567, 1588, 1632, 1653, 1897, 1914, 1933, 1955, 1980, 2006, 2031, 2056, 2079, 2124, 2155, 2167, 2220, 2241, 2330, 2408, 2471, 2509, 2557, 2593, 2629, 2657, 2987, 3311, 3385, 3420, 3463, 3510, 3524, 3593, 3659, 3702, 4507, 4610], 'Scopus': [540, 592, 664, 728, 792, 856, 902, 1029, 1108, 1210, 1337, 1416, 1459, 1472, 1506, 1568, 1589, 1633, 1654, 1898, 1915, 1934, 1956, 1981, 2007, 2032, 2057, 2080, 2156, 2221, 2242, 2331, 2409, 2472, 2510, 2558, 2594, 2630, 2658, 2988, 3312, 3386, 3421, 3464, 3511, 3525, 3594, 3660, 3703, 4508, 4611], '(15)': [541], 'Google': [542, 594, 666, 705, 730, 794, 858, 904, 1031, 1110, 1187, 1212, 1339, 1418, 1461, 1474, 1508, 1570, 1591, 1635, 1656, 1900, 1917, 1936, 1958, 1983, 2009, 2034, 2059, 2082, 2125, 2158, 2168, 2223, 2244, 2333, 2411, 2474, 2512, 2560, 2596, 2632, 2660, 2990, 3314, 3388, 3423, 3466, 3490, 3513, 3527, 3539, 3596, 3662, 3705, 4510, 4613], 'Scholar,': [543, 667, 706, 731, 795, 859, 905, 1032, 1188, 1213, 1340, 1462, 1571, 1636, 1901, 1918, 1937, 1959, 1984, 2010, 2035, 2060, 2159, 2224, 2475, 2513, 2561, 2597, 2633], '2Poutanen': [544], 'S.M.': [545, 929, 1237], 'Low': [546], 'D.E.': [547, 955, 1263, 2145], 'Henry': [548], 'B.': [549, 769, 1011, 1048, 1082, 1319, 1356, 1390, 2116, 2635, 3505], 'Finkelstein': [550], 'S.': [551, 605, 611, 615, 637, 641, 647, 671, 679, 681, 695, 714, 716, 743, 745, 835, 989, 999, 1005, 1046, 1054, 1080, 1092, 1153, 1161, 1163, 1177, 1196, 1198, 1297, 1307, 1313, 1354, 1362, 1388, 1400, 1446, 1967, 1975, 2051, 2466, 2504, 2599, 2619], 'Rose': [552], 'D.': [553, 561, 735, 809, 931, 973, 1009, 1066, 1239, 1281, 1317, 1374, 1464, 1941, 2674, 2899], 'Green': [554], 'K.': [555, 635, 677, 708, 841, 969, 1050, 1086, 1159, 1190, 1277, 1358, 1394, 1961, 2515, 2543, 2675, 2900], 'Tellier': [556], 'R.': [557, 559, 699, 720, 829, 981, 1007, 1042, 1090, 1181, 1202, 1289, 1315, 1350, 1398, 1577, 2230, 2483, 2494], 'Draker': [558], 'Adachi': [560], 'Ayers': [562], 'M.': [563, 577, 579, 619, 631, 645, 669, 685, 687, 712, 801, 939, 975, 977, 983, 985, 1015, 1017, 1060, 1088, 1151, 1167, 1169, 1194, 1247, 1283, 1285, 1291, 1293, 1323, 1325, 1368, 1396, 1903, 1969, 1986, 1988, 2448, 2547, 2639, 3366, 3413, 3444, 3574, 3652, 3683], 'Chan': [564, 822, 882, 924, 1232], 'A.K.': [565, 2615], 'Skowronski': [566, 1018, 1326], 'D.M.': [567, 1019, 1327, 1623, 2452], 'Salit': [568], 'I.': [569, 2688, 2913], 'Simor': [570], 'A.E.': [571, 757, 821], 'Slutsky': [572], 'A.S.': [573, 947, 1255], 'Doyle': [574], 'P.W.': [575], 'Krajden': [576, 1014, 1322], 'Petric': [578, 1016, 1324], 'Brunham': [580, 1012, 1320], 'R.C.': [581, 1013, 1321], 'McGeer': [582], 'A.J.': [583, 2491], 'N.': [584, 633, 656, 775, 784, 837, 933, 967, 1241, 1275, 2679, 2904, 3517], 'Engl.': [585, 657, 785], 'J.': [586, 629, 658, 763, 771, 786, 873, 919, 1084, 1227, 1392, 1452, 1465, 1556, 1583, 1963, 1965, 1990, 2002, 2119, 2150, 2162, 2209, 2236, 2397, 2485, 2519, 2529, 2563, 2607, 2613, 2646, 2664, 2687, 2889, 2912, 2976, 3364, 3442, 3484, 3533, 3572, 3681, 4496, 4599], 'Med.': [587, 659, 787], '348:': [589, 661, 789], '1995-2005Crossref': [590], '(1019)': [593], 'Scholar)': [595, 3424, 3597, 3663], 'caused': [596], 'novel': [599], 'coronavirus,': [600, 1704], 'SARS-CoV': [601, 1115, 2421, 2741, 2773, 2822, 2865, 2934, 2996, 4216, 4227, 4307, 4621, 4687, 4721, 4733], '(3Drosten': [602], 'C.': [603, 689, 747, 831, 1021, 1072, 1096, 1171, 1329, 1380, 1404, 2456, 2489, 2539, 2571], 'Gunther': [604, 1091, 1399], 'Preiser': [606], 'W.': [607, 751, 819, 871, 1920, 2012, 2037, 2537, 3305], 'van': [608, 804, 807, 815, 832, 1574, 2227], 'der': [609, 833, 1575, 2228], 'Werf': [610, 834], 'Brodt': [612], 'H.R.': [613], 'Becker': [614, 670, 713, 1152, 1195], 'Rabenau': [616], 'H.': [617, 653, 941, 965, 991, 1249, 1273, 1299, 1448, 1549, 2118, 2202, 2390, 2549, 2575, 2611, 2690, 2915, 2969, 4489, 4592], 'Panning': [618], 'Kolesnikova': [620], 'L.': [621, 979, 1058, 1287, 1366, 1543, 2196, 2384, 2517, 2545, 2677, 2681, 2902, 2906, 2963, 4483, 4586], 'Fouchier': [622, 798, 1089, 1397], 'R.A.': [623, 799, 913, 1221, 2066, 3477], 'Berger': [624, 1942], 'A.': [625, 697, 915, 927, 953, 963, 987, 993, 995, 1056, 1078, 1179, 1223, 1235, 1261, 1271, 1295, 1301, 1303, 1364, 1386, 1922, 1976, 2014, 2052, 2141, 2458, 2460, 2467, 2505, 3416, 3501, 3655], 'Burguiere': [626], 'A.M.': [627, 1998], 'Cinatl': [628], 'Eickmann': [630, 711, 1193], 'Escriou': [632, 836], 'Grywna': [634], 'Kramme': [636], 'Manuguerra': [638, 838], 'J.C.': [639, 839], 'Muller': [640], 'Rickerts': [642], 'V.': [643, 683, 710, 1165, 1192, 1451], 'Sturmer': [644], 'Vieth': [646], 'Klenk': [648, 672, 717, 1154, 1199], 'H.D.': [649, 673, 718, 1155, 1200], 'Osterhaus': [650, 844, 1093, 1401, 2495], 'A.D.': [651, 845, 1094, 1402, 2496], 'Schmitz': [652], 'Doerr': [654, 674, 1156], 'H.W.': [655, 675, 1157], '1967-1976Crossref': [662], '(3455)': [665], '4Eickmann': [668], 'Stadler': [676, 1158], 'Censini': [678, 1160], 'Guidotti': [680, 1162], 'Masignani': [682, 709, 1164, 1191], 'Scarselli': [684, 1166], 'Mora': [686, 1168], 'Donati': [688, 1170], 'Han': [690, 1172], 'J.H.': [691, 1173], 'Song': [692, 1174], 'H.C.': [693, 1175], 'Abrignani': [694, 715, 1176, 1197], 'Covacci': [696, 1178], 'Rappuoli': [698, 719, 1180, 1201], 'Science.': [700, 1024, 1103, 1182, 1332, 1411], '302:': [702, 1184], '1504-1505Crossref': [703, 1185], '5Stadler': [707, 1189], 'Nat.': [721, 1203, 1908], 'Rev.': [722, 1204, 1627, 1646], 'Microbiol.': [723, 1205], '1:': [725, 1207], '209-218Crossref': [726, 1208], '(374)': [729, 1211], '6Ksiazek': [732], 'T.G.': [733, 1074, 1382, 1642], 'Erdman': [734, 1067, 1375], 'Goldsmith': [736], 'C.S.': [737], 'Zaki': [738], 'S.R.': [739, 937, 1245], 'Peret': [740, 1069, 1377], 'T.': [741, 797, 814, 2523, 3374, 3452, 3582, 3691], 'Emery': [742], 'Tong': [744, 1053, 1361], 'Urbani': [746], 'Comer': [748], 'J.A.': [749], 'Lim': [750, 818, 870], 'Rollin': [752, 1075, 1383], 'P.E.': [753, 1076, 1384], 'Dowell': [754], 'S.F.': [755], 'Ling': [756, 820, 2538], 'Humphrey': [758], 'C.D.': [759, 765], 'Shieh': [760], 'W.J.': [761, 781, 1102, 1410], 'Guarner': [762], 'Paddock': [764], 'Rota': [766], 'P.': [767, 1551, 2204, 2392, 2444, 2527, 2583, 2617, 2692, 2917, 2971, 3358, 3436, 3566, 3675, 4491, 4594], 'Fields': [768], 'DeRisi': [770, 1061, 1369], 'Yang': [772, 958, 1266], 'J.Y.': [773, 3409, 3648], 'Cox': [774], 'Hughes': [776], 'J.M.': [777, 957, 1265, 1644, 1943, 3483], 'LeDuc': [778], 'J.W.': [779], 'Bellini': [780, 1101, 1409], 'Anderson': [782, 1099, 1407], 'L.J.': [783, 1100, 1408, 2039], '1953-1966Crossref': [790], '(3375)': [793], '7Kuiken': [796], 'Schutten': [800], 'Rimmelzwaan': [802], 'G.F.': [803, 1553, 2206, 2394, 2585, 2973, 4493, 4596], 'Amerongen': [805], 'G.': [806, 817, 2450, 2565, 2601, 2697, 2922], 'Riel': [808], 'Laman': [810], 'J.D.': [811], 'de': [812, 1578, 2231], 'Jong': [813], 'Doornum': [816], 'P.K.': [823, 945, 1253], 'Tam': [824], 'J.S.': [825, 843, 861, 3362, 3440, 3570, 3679], 'Zambon': [826], 'M.C.': [827, 3519], 'Gopal': [828], 'Drosten': [830, 1095, 1403], 'Stohr': [840], 'Peiris': [842], 'Lancet.': [846, 892, 2620], '362:': [848], '263-270Abstract': [849], 'Full': [850, 852, 896, 898, 1562, 1564, 1950, 1952, 2026, 2028, 2074, 2076, 2215, 2217, 2325, 2327, 2403, 2405, 2624, 2626, 2652, 2654, 2982, 2984, 4502, 4504, 4605, 4607], 'Text': [851, 853, 897, 899, 1563, 1565, 1951, 1953, 2027, 2029, 2075, 2077, 2216, 2218, 2326, 2328, 2404, 2406, 2625, 2627, 2653, 2655, 2983, 2985, 4503, 4505, 4606, 4608], 'PDF': [854, 900, 1566, 1954, 2030, 2078, 2219, 2329, 2407, 2628, 2656, 2986, 4506, 4609], '(840)': [857], '8Peiris': [860], 'Lai': [862, 2544], 'S.T.': [863], 'Poon': [864], 'L.L.': [865], 'Guan': [866], 'Y.': [867, 997, 1305, 1537, 1539, 2190, 2192, 2378, 2380, 2533, 2567, 2573, 2603, 2605, 2666, 2672, 2891, 2897, 2957, 2959, 4477, 4479, 4580, 4582], 'Yam': [868], 'L.Y.': [869], 'Nicholls': [872], 'Yee': [874], 'W.K.': [875], 'Yan': [876, 2574], 'W.W.': [877], 'Cheung': [878], 'M.T.': [879], 'Cheng': [880], 'V.C.': [881], 'K.H.': [883, 2016], 'Tsang': [884], 'D.N.': [885], 'Yung': [886], 'R.W.': [887, 3360, 3438, 3568, 3677], 'Ng': [888], 'T.K.': [889], 'Yuen': [890], 'K.Y.': [891], '361:': [894], '1319-1325Abstract': [895], '(2361)': [903], '9Marra': [906, 1214], 'M.A.': [907, 1098, 1215, 1406], 'Jones': [908, 988, 1216, 1296], 'S.J.': [909, 1217, 1992], 'Astell': [910, 1218], 'C.R.': [911, 1219, 2609], 'Holt': [912, 1220], 'Brooks-Wilson': [914, 1222], 'Butterfield': [916, 1224], 'Y.S.': [917, 1225], 'Khattra': [918, 1226], 'Asano': [920, 1228], 'J.K.': [921, 1229], 'Barber': [922, 1230], 'S.A.': [923, 1231, 2041], 'S.Y.': [925, 1233], 'Cloutier': [926, 1234], 'Coughlin': [928, 1236], 'Freeman': [930, 1238], 'Girn': [932, 1240], 'Griffith': [934, 1242], 'O.L.': [935, 1243], 'Leach': [936, 1244], 'Mayo': [938, 1246], 'McDonald': [940, 1248], 'Montgomery': [942, 1250], 'S.B.': [943, 1251], 'Pandoh': [944, 1252], 'Petrescu': [946, 1254], 'Robertson': [948, 1256], 'A.G.': [949, 1257], 'Schein': [950, 1258], 'J.E.': [951, 1259], 'Siddiqui': [952, 1260], 'Smailus': [954, 1262], 'Stott': [956, 1264], 'G.S.': [959, 1267], 'Plummer': [960, 1268], 'F.': [961, 1269, 2161, 2569, 2670, 2698, 2895, 2923], 'Andonov': [962, 1270], 'Artsob': [964, 1272], 'Bastien': [966, 1274], 'Bernard': [968, 1276], 'Booth': [970, 1278], 'T.F.': [971, 1279], 'Bowness': [972, 1280], 'Czub': [974, 1282], 'Drebot': [976, 1284], 'Fernando': [978, 1286], 'Flick': [980, 1288], 'Garbutt': [982, 1290], 'Gray': [984, 1292], 'Grolla': [986, 1294], 'Feldmann': [990, 1298], 'Meyers': [992, 1300], 'Kabani': [994, 1302], 'Li': [996, 1304, 1544, 2197, 2385, 2964, 4484, 4587], 'Normand': [998, 1306], 'Stroher': [1000, 1308], 'U.': [1001, 1309, 1974, 2050, 2465, 2503], 'Tipples': [1002, 1310], 'G.A.': [1003, 1311], 'Tyler': [1004, 1312], 'Vogrig': [1006, 1314], 'Ward': [1008, 1316], 'Watson': [1010, 1318], 'Upton': [1020, 1328], 'Roper': [1022, 1330], 'R.L.': [1023, 1331], '300:': [1026, 1105, 1334, 1413], '1399-1404Crossref': [1027, 1335], '(1768)': [1030, 1338], '10Rota': [1033, 1341], 'P.A.': [1034, 1342, 1886], 'Oberste': [1035, 1343], 'M.S.': [1036, 1344], 'Monroe': [1037, 1345], 'S.S.': [1038, 1346], 'Nix': [1039, 1347], 'W.A.': [1040, 1348], 'Campagnoli': [1041, 1349], 'Icenogle': [1043, 1351], 'J.P.': [1044, 1352], 'Penaranda': [1045, 1353], 'Bankamp': [1047, 1355], 'Maher': [1049, 1357], 'Chen': [1051, 1063, 1359, 1371, 2518, 2602], 'M.H.': [1052, 1360], 'Tamin': [1055, 1363], 'Lowe': [1057, 1365], 'Frace': [1059, 1367], 'J.L.': [1062, 1370], 'Q.': [1064, 1372], 'Wang': [1065, 1373, 1964, 2536], 'D.D.': [1068, 1376], 'T.C.': [1070, 1378], 'Burns': [1071, 1379], 'Ksiazek': [1073, 1381], 'Sanchez': [1077, 1385], 'Liffick': [1079, 1387], 'Holloway': [1081, 1389], 'Limor': [1083, 1391], 'McCaustland': [1085, 1393], 'Olsen-Rasmussen': [1087, 1395], 'Pallansch': [1097, 1405], '1394-1399Crossref': [1106, 1414], '(2115)': [1109, 1417], 'Scholar).': [1111, 1419, 1475, 1509, 1592, 2083, 2126, 2245, 2334, 2412, 2661, 2991, 3315, 3389, 3467, 3491, 3540, 3706, 4614], 'Phylogenetic': [1112], 'analysis': [1113, 1833], 'shows': [1116, 1844, 2793, 4316], 'that': [1117, 1513, 1528, 1664, 1845, 2105, 2247, 2416, 2739, 2811, 3804, 4651, 4702], 'it': [1118, 1137], 'not': [1120, 3811, 3963], 'closely': [1121], 'related': [1122], 'any': [1124, 1431, 4418], 'previously': [1127], 'coronaviruses': [1129, 1487, 4694], 'isolated': [1130], 'from': [1131, 1838, 2279, 2722, 2850, 3623, 3821, 4620, 4681, 4709], 'either': [1132], 'humans': [1133], 'or': [1134, 1757, 4445], 'animals,': [1135], 'has': [1138, 4005, 4576], 'therefore': [1139], 'assigned': [1141], 'new,': [1144], 'distinct': [1145], 'group': [1146, 3236], 'within': [1147], 'genus': [1149], '(4Eickmann': [1150], 'Coronaviruses': [1420], 'enveloped,': [1422], 'positive-strand': [1423], 'RNA': [1424, 1432], 'viruses': [1425], 'largest': [1428], 'genomes': [1429], '3–4': [1438], 'envelope': [1439], 'embedded': [1441], '(11Siddell': [1445], 'Wege': [1447], 'Ter': [1449], 'Meulen': [1450], 'Gen.': [1453, 1466], 'Virol.': [1454, 1467, 1584, 2120, 2151, 2163, 2237], '1983;': [1455, 1468], '64:': [1456, 1469, 2122], '761-776Crossref': [1457], '(187)': [1460], '12Cavanagh': [1463], '2577-2583Crossref': [1470], '(113)': [1473], 'Both': [1476], 'receptor': [1478, 1756, 2137], 'binding': [1479, 1753, 2138, 2291, 2708, 2765, 2871], 'process': [1485], 'mediated': [1489], '(S': [1495], 'protein)': [1496, 1619, 2867], '(13Gallagher': [1497], 'T.M.': [1498], 'Buchmeier': [1499], 'M.J.': [1500], 'Virology.': [1501], '2001;': [1502, 1629], '279:': [1503, 1560, 2213, 2401, 2650, 2980, 4500, 4603], '371-374Crossref': [1504], '(489)': [1507], 'Recent': [1510, 2413], 'studies': [1511, 2414, 2704, 2878], 'show': [1512, 2415], 'murine': [1514, 2343], '(mouse': [1516], '(MHV))': [1519], 'uses': [1520], 'spike-mediated': [1522], 'so-called': [1530], '(14Xu': [1536, 2189, 2377, 2956, 4476, 4579], 'Liu': [1538, 1962, 2191, 2379, 2572, 2958, 4478, 4581], 'Lou': [1540, 2193, 2381, 2960, 4480, 4583], 'Z.': [1541, 1547, 1555, 2194, 2200, 2208, 2382, 2388, 2396, 2531, 2581, 2668, 2685, 2694, 2893, 2910, 2919, 2961, 2967, 2975, 3303, 4481, 4487, 4495, 4584, 4590, 4598], 'Qin': [1542, 2195, 2383, 2962, 4482, 4585], 'X.': [1545, 2198, 2386, 2521, 2525, 2535, 2541, 2683, 2908, 2965, 4485, 4588], 'Bai': [1546, 2199, 2387, 2966, 4486, 4589], 'Pang': [1548, 2201, 2389, 2968, 4488, 4591], 'Tien': [1550, 2203, 2391, 2582, 2616, 2970, 4490, 4593], 'Gao': [1552, 2205, 2393, 2584, 2972, 4492, 4595], 'Rao': [1554, 2207, 2395, 2524, 2580, 2974, 4494, 4597], 'Biol.': [1557, 1649, 1910, 2210, 2398, 2647, 2977, 3380, 3458, 3588, 3697, 4497, 4600], 'Chem.': [1558, 2211, 2399, 2648, 2978, 4498, 4601], '2004;': [1559, 2212, 2400, 2468, 2506, 2554, 2590, 2621, 2649, 2979, 4499, 4602], '30514-30522Abstract': [1561, 2214, 2402, 2981, 4501, 4604], '(111)': [1569, 2058, 2222, 2410, 2989, 4509, 4612], '15Bosch': [1572, 2225], 'B.J.': [1573, 2226, 2477, 2487], 'Zee': [1576, 2229, 2482], 'Haan': [1579, 2232], 'C.A.': [1580, 2233], 'Rottier': [1581, 2234, 2497], 'P.J.': [1582, 2147, 2235, 2498, 3532], '77:': [1586, 2153, 2239], '8801-8811Crossref': [1587, 2240], '(996)': [1590, 2243], 'Class': [1593, 1731], 'including': [1598, 3893], 'hemagglutinin': [1600, 1705], 'influenza': [1603, 1710, 2373], 'virus,': [1604, 1614, 1711, 1718, 1724], 'gp160': [1605], '(HIV-1),': [1610], 'Ebola': [1613, 1723], '(F': [1618, 3953], 'paramyxovirus': [1621], '(16Eckert': [1622], 'Kim': [1624, 1906, 1944, 2319], 'P.S.': [1625, 1907, 1945, 2320], 'Annu.': [1626, 1645], 'Biochem.': [1628, 2550, 2586], '70:': [1630], '777-810Crossref': [1631], '(1146)': [1634], '17Hernandez': [1637], 'L.D.': [1638], 'Hoffman': [1639], 'L.R.': [1640], 'Wolfsberg': [1641], 'White': [1643], 'Cell': [1647], 'Dev.': [1648], '1996;': [1650], '12:': [1651], '627-661Crossref': [1652], '(509)': [1655], 'Scholar),': [1657, 2169, 3514, 3528, 4511], 'all': [1659, 4673], 'type': [1660, 2101], 'transmembrane': [1662], 'glycoproteins': [1663, 1678], 'displayed': [1666], 'as': [1673, 1681, 1861, 3001, 3204, 3334, 3607, 3984, 4535], 'oligomers.': [1674], 'Most': [1675], 'these': [1677, 1691, 1835, 1846, 4270], 'synthesized': [1680, 2430], 'single': [1682, 3003], 'chain': [1683, 3004], 'precursors': [1684, 1692], 'containing': [1685, 3155], 'protease': [1687], 'cleavage': [1688], 'site,': [1689], 'cleaved': [1694], 'into': [1695, 1794, 2107, 3057, 4085, 4444, 4466], 'noncovalently': [1697], 'associated': [1698], 'subunits:': [1699], 'S1': [1700], 'S2': [1702], '2': [1708, 3132], 'gp120': [1712], '+': [1713], 'gp41': [1714], 'HIV/simian': [1716], 'glycoprotein-1': [1719], '-2': [1721, 1728], 'F1': [1726], 'paramyxovirus.': [1730], 'also': [1736, 2705, 2827, 4404, 4527], 'contain': [1737, 3240, 4405], 'peptide': [1740, 2180], 'least': [1743], 'termed': [1748], 'After': [1752], 'induced': [1758], 'low': [1760], 'pH,': [1761], 'undergo': [1765], 'series': [1767, 2365], 'conformational': [1769, 2249, 2367], 'changes': [1770, 2250, 2368], 'mediate': [1772], 'first': [1776], 'step': [1777], 'involves': [1778], 'exposure': [1779], 'peptide,': [1783], 'region': [1786, 2436, 4280], 'membrane-anchored': [1789, 2172], 'subunit,': [1790], 'then': [1792, 3117], 'inserts': [1793], 'lipid': [1797], 'bilayer.': [1798], 'Subsequently,': [1799], 'peptides': [1803, 2277, 2281, 2431, 2720, 2859, 3037, 4679], 'trimer-of-hairpins-like': [1806], 'via': [1808, 3015], 'transient': [1810], 'pre-hairpin': [1811], 'intermediate': [1812, 2258, 2304], 'facilitate': [1814, 3028], 'juxtaposition': [1815], 'membranes': [1821], 'followed': [1822], 'virus-cell': [1824], 'Biochemical': [1830], 'cores': [1837, 4708], 'complexes': [1847], 'stable': [1855, 2426, 4532], 'bundle,': [1857, 2428], 'designated': [1860], 'surrounded': [1875, 4065], 'oblique,': [1882, 4072], 'manner': [1884, 2289, 4074], '(18Bullough': [1885], 'Hughson': [1887], 'F.M.': [1888], 'Skehel': [1889, 1925, 2017, 2042], 'J.J.': [1890, 1926, 2018, 2043], 'Wiley': [1891, 1927, 2019, 2044], 'D.C.': [1892, 1928, 1939, 2020, 2045, 2318], 'Nature.': [1893, 1929], '1994;': [1894], '371:': [1895], '37-43Crossref': [1896], '(1379)': [1899], '19Lu': [1902], 'Blacklow': [1904], 'S.C.': [1905, 1924], 'Struct.': [1909], '1995;': [1911, 2164], '2:': [1912, 2024], '1075-1082Crossref': [1913], '(671)': [1916], '20Weissenhorn': [1919], 'Dessen': [1921], 'Harrison': [1923], '1997;': [1930, 1947, 1977, 3308, 3521], '387:': [1931], '426-430Crossref': [1932], '(1466)': [1935], '21Chan': [1938], 'Fass': [1940], 'Cell.': [1946, 2022, 2070, 2321], '89:': [1948], '263-273Abstract': [1949], '(1841)': [1957], '22Tan': [1960], 'Shen': [1966], 'Lu': [1968], 'Proc.': [1970, 2046, 2461, 2499], 'Natl.': [1971, 2047, 2462, 2500], 'Acad.': [1972, 2048, 2463, 2501], 'Sci.': [1973, 2049, 2464, 2502], '94:': [1978], '12303-12308Crossref': [1979], '(519)': [1982], '23Caffrey': [1985], 'Cai': [1987], 'Kaufman': [1989], 'Stahl': [1991], 'Wingfield': [1993], 'P.T.': [1994], 'Covell': [1995], 'D.G.': [1996], 'Gronenborn': [1997], 'Clore': [1999, 3353, 3431, 3561, 3670], 'G.M.': [2000, 3354, 3432, 3562, 3671], 'EMBO': [2001], '1998;': [2003, 2023, 2053, 2322, 3382, 3460, 3590, 3699], '17:': [2004], '4572-4584Crossref': [2005], '(371)': [2008], '24Weissenhorn': [2011], 'Carfi': [2013, 2457], 'Lee': [2015], 'Mol.': [2021, 2069], '605-616Abstract': [2025], '(357)': [2033], '25Weissenhorn': [2036], 'Calder': [2038], 'Wharton': [2040], '95:': [2054], '6032-6036Crossref': [2055], '26Baker': [2061], 'K.A.': [2062, 3503], 'Dutch': [2063], 'R.E.': [2064], 'Lamb': [2065], 'Jardetzky': [2067], 'T.S.': [2068], '1999;': [2071], '3:': [2072], '309-319Abstract': [2073], '(342)': [2081], 'many': [2089], 'features': [2090], 'It': [2098], 'associates': [2106], 'trimers': [2108, 3614], '(27Delmas': [2115], 'Laude': [2117], '1990;': [2121], '5367-5375Crossref': [2123], 'distal': [2128], 'subunit': [2129, 2173], '(S1)': [2130], 'contains': [2135, 2175, 3888], 'domain': [2139], '(28Bonavia': [2140], 'Zelus': [2142], 'B.D.': [2143], 'Wentworth': [2144], 'Talbot': [2146], 'Holmes': [2148, 2640, 2642], 'K.V.': [2149, 2643], '2530-2538Crossref': [2154], '(159)': [2157], '29Taguchi': [2160], '69:': [2165], '7260-7263Crossref': [2166], '(S2)': [2174], 'putative': [2177], 'internal': [2178], '(HR1': [2186, 2860], 'HR2)': [2188], 'Agents': [2246], 'prevent': [2248, 2263], 'stabilizing': [2256], 'state': [2259, 2305], 'expected': [2261], 'activation': [2265], 'and,': [2266], 'thus,': [2267], 'inhibit': [2268, 2284], 'In': [2271, 3996, 4615], 'case': [2273], 'HIV-1': [2275, 2376], 'gp41,': [2276], 'derived': [2278, 2721, 4680], 'C': [2280, 3982, 4142, 4193], 'can': [2282, 4660], 'effectively': [2283], 'infection': [2285, 2823], 'dominant-negative': [2288], 'transiently': [2294], 'exposed': [2295, 4555], 'consequently': [2307], 'formation': [2310], '(30Chan': [2317], '93:': [2323], '681-684Abstract': [2324], '(1119)': [2332], 'We': [2335], 'recently': [2337], 'three-dimensional': [2340, 2729, 4000], 'MHV': [2345, 2805, 2883, 2954, 3328, 3600, 4023, 4099, 4236, 4259, 4303, 4397, 4560, 4571, 4623, 4653, 4719, 4730], 'proposed': [2351], 'model': [2353, 3391, 3630], 'coronavirus-mediated': [2355], 'S': [2361], 'undergoes': [2363], 'corresponding': [2432, 2945], 'inhibitory': [2438], 'activity': [2439], '(31Ingallinella': [2443], 'Bianchi': [2445], 'E.': [2446], 'Finotto': [2447], 'Cantoni': [2449], 'Eckert': [2451], 'Supekar': [2453], 'V.M.': [2454], 'Bruckmann': [2455], 'Pessi': [2459], '101:': [2469, 2507], '8709-8714Crossref': [2470], '(77)': [2473], '32Bosch': [2476], 'Martina': [2478], 'B.E.': [2479], 'Van': [2480], 'Der': [2481], 'Lepault': [2484], 'Haijema': [2486], 'Versluis': [2488], 'Heck': [2490], 'De': [2492], 'Groot': [2493], '8455-8460Crossref': [2508], '(298)': [2511], '33Yuan': [2514], 'Yi': [2516], 'Qu': [2520], 'Qing': [2522], 'Jiang': [2526, 2618, 3361, 3439, 3569, 3678], 'Hu': [2528], 'Xiong': [2530, 2610], 'Nie': [2532], 'Shi': [2534], 'Yin': [2540], 'Fan': [2542], 'Ding': [2546], 'Deng': [2548], 'Biophys.': [2551, 2587], 'Res.': [2552, 2588], 'Commun.': [2553, 2589], '319:': [2555, 2591], '746-752Crossref': [2556], '(94)': [2559], '34Zhu': [2562], 'Xiao': [2564, 2600], 'Xu': [2566], 'Yuan': [2568], 'Zheng': [2570], 'Cole': [2576], 'D.K.': [2577], 'Bell': [2578], 'J.I.': [2579], '283-288Crossref': [2592], '(91)': [2595], '35Liu': [2598], 'He': [2604], 'Niu': [2606], 'Escalante': [2608], 'Farmar': [2612], 'Debnath': [2614], '363:': [2622], '938-947Abstract': [2623], '(420)': [2631], '36Tripet': [2634], 'Howard': [2636], 'M.W.': [2637, 3479], 'Jobling': [2638], 'R.K.': [2641], 'Hodges': [2644], 'R.S.': [2645], '20836-20849Abstract': [2651], '(177)': [2659], '2Y.': [2662, 2887], 'Xu,': [2663, 2888], 'Zhu,': [2665, 2890], 'Liu,': [2667, 2673, 2892, 2898], 'Lou,': [2669, 2894], 'Yuan,': [2671, 2896], 'Cole,': [2676, 2901], 'Ni,': [2678, 2903], 'Su,': [2680, 2905], 'Qin,': [2682, 2907], 'Li,': [2684, 2909], 'Bai,': [2686, 2911], 'Bell,': [2689, 2914], 'Pang,': [2691, 2916], 'Tien,': [2693, 2918], 'Rao,': [2695, 2920], 'Gao,': [2699, 2924], 'submitted': [2700, 2925], 'publication.': [2702, 2927], 'propose': [2706], 'between': [2710, 3032, 4173, 4211, 4226, 4291, 4362, 4376, 4636], 'identify': [2715], 'efficiency': [2718], 'region.': [2725], 'However,': [2726], 'detailed': [2728, 2830], 'HR1/HR2': [2733], 'complex': [2734, 2785, 3049], 'remains': [2735], 'unknown.': [2736], 'To': [2737], 'verify': [2738], 'indeed': [2744], 'forms': [2745], 'trimer-of-hairpins': [2747], 'provide': [2751], 'inhibitors,': [2761], 'we': [2762, 3977], 'HR': [2769], 'solved': [2777, 3549], 'crystal': [2779, 3173, 3543], 'this': [2782, 4525], 'especially': [2804], 'core,': [2809], 'approach': [2814], 'might': [2815, 4712], 'identifying': [2819], 'inhibitors': [2820], 'effectively.': [2824], 'provides': [2828], 'important': [2829], 'based': [2838], 'drug': [2839], 'design.': [2840], 'Construction,': [2841], 'Expression,': [2842], 'Purification—The': [2844], 'SARS': [2845, 2851, 3006, 3063, 3171, 3242, 3319, 3546, 3616, 3890, 3986, 3998, 4033, 4261, 4402, 4643], 'gene': [2847, 3054], 'cloned': [2849], 'GZ02': [2853], '(GenBank™': [2854], 'accession': [2855], 'number': [2856], 'AY390556).': [2857], 'Two': [2858], 'interact,': [2868], 'their': [2870, 3973, 4630], 'were': [2873, 3292, 3343, 3494, 3621], 'biochemical': [2877], 'sequence': [2880, 4632, 4697], 'alignment': [2881], 'complex.': [2886], 'consist': [2937], 'residues': [2939, 2942, 3894, 3904, 3914, 3924, 3934, 3945, 3961, 4109, 4131, 4138, 4347, 4378, 4442, 4463, 4540, 4554], '900–948': [2940], '1145–1184,': [2943], 'respectively,': [2944], 'prepared': [3000], '(termed': [3005], '2-Helix)': [3007, 3617], 'linking': [3009], 'domains': [3014], '22-amino': [3017], 'acid': [3018, 3084], 'linker': [3019, 3957], '(LVPRGSGGSGGSGGLEVLFQGP),': [3020], 'flexible': [3023], 'long': [3025], 'enough': [3026], 'natural': [3030], 'interaction': [3031, 4170, 4279, 4375], 'allows': [3039], 'easy': [3041], 'expression': [3042], 'purification': [3044], '(Fig.': [3050, 4075, 4120, 4468, 4656, 4722], '1A).': [3051], 'PCR-directed': [3053], 'inserted': [3056], 'pET22b': [3058], '(Novagen)': [3059], 'vector,': [3060], '2-Helix': [3064, 3172, 3243, 3320, 3329, 3547, 3601, 3891, 3999, 4024, 4046, 4100, 4403, 4561, 4731, 4734], 'expressed': [3067], 'LB': [3069], 'culture': [3070], 'medium': [3071], 'Escherichia': [3073], 'coli': [3074], 'strain': [3075], 'BL21(DE3).': [3076], 'product': [3078], 'purified': [3080, 3090, 3103], 'nickel': [3082], 'nitrilotriacetic': [3083], 'affinity': [3085], 'chromatography': [3086, 3094], 'further': [3089, 3394, 3633], 'gel': [3092], 'filtration': [3093], '(Superdex': [3095], '75™,': [3096], 'Amersham': [3097], 'Biosciences).': [3098], 'Crystallization': [3099], 'Structure': [3101, 3541], 'Determination—The': [3102, 3542], 'dialyzed': [3106], '10': [3108, 3113], 'mm': [3109, 3114], 'Tris-HCl,': [3110], 'pH': [3111, 3160, 3198], '8.0,': [3112], 'NaCl': [3115], 'concentrated': [3118], '15': [3120], 'mg': [3121], 'ml-1.': [3122], 'Crystals': [3123], 'diffracting': [3126], 'quality': [3127, 3469], 'could': [3128, 3962], 'obtained': [3130], 'after': [3131], 'weeks': [3133], 'using': [3135, 3188, 3297, 3402, 3553, 3641], 'hanging': [3137], 'drop': [3138, 3144], 'method': [3139], 'equilibrating': [3141], '2-μl': [3143], '(protein': [3145], 'solution': [3146], 'mixed': [3147], '1:1': [3148], 'reservoir': [3150, 3154], 'solution)': [3151], '0.1': [3156, 3194], 'm': [3157, 3167, 3195], 'citric': [3158, 3196], 'acid,': [3159, 3197], '2.5,': [3161, 3199], '10–15%': [3162], 'polyethylene': [3163, 3201], 'glycol': [3164, 3202], '4000,': [3165], '0.02': [3166], 'spermidine': [3168], 'tetra-HCl.': [3169], 'mounted': [3175], 'nylon': [3177], 'loops': [3178], 'flash-frozen': [3180], 'cold': [3182], 'nitrogengas': [3183], 'stream': [3184], '100': [3186], 'K': [3187], 'Oxford': [3190], 'Cryosystems': [3191], 'coldstream': [3192], '25%': [3200], '4000': [3203], 'cryoprotectant.': [3206], 'crystals': [3208, 3239], 'unit-cell': [3210], 'parameters': [3211], '=': [3213, 3217, 3221, 3225, 3227, 3230, 3282, 3771, 3788, 3829, 3833, 3837, 3841], '121.2': [3214, 3830], 'Å,': [3215, 3219, 3223, 3831, 3835, 3839], 'b': [3216, 3832], '66.3': [3218, 3834], 'c': [3220, 3836, 4736], '70.0': [3222, 3838], 'α': [3224], 'γ': [3226], '90°,': [3228], 'β': [3229, 3840], '107.4°': [3231], 'belong': [3233], 'space': [3235], 'C2.': [3237], '6': [3241], 'molecules': [3244, 3612, 3983], 'one': [3246], 'asymmetric': [3247, 3619, 3886], 'unit,': [3248], 'diffraction': [3251], 'pattern': [3252, 4526], 'extends': [3253], 'Data': [3259, 3291], 'collection': [3260, 3756, 3824], 'performed': [3262, 3344], 'in-house': [3263], 'Rigaku': [3266], 'RU2000': [3267], 'rotating': [3268], 'copper-anode': [3269], 'x-ray': [3270], 'generator': [3271], 'operated': [3272], '48': [3274], 'kV': [3275], '98': [3277], 'mA': [3278], '(Cu': [3279], 'Kα;': [3280], 'λ': [3281], '1.5418': [3283], 'Å)': [3284], 'MAR': [3287], '345': [3288], 'image-plate': [3289], 'detector.': [3290], 'indexed,': [3293], 'integrated,': [3294], 'scaled': [3296], 'DENZO': [3298], 'SCALEPACK': [3300], 'programs': [3301, 3404, 3498, 3643], '(38Otwinowski': [3302], 'Minor': [3304], 'Methods': [3306], 'Enzymol.': [3307], '276:': [3309], '307-326Crossref': [3310], '(38573)': [3313], 'molecular': [3324, 3551], 'replacement': [3325, 3552], '(PDB': [3331, 3603], 'code': [3332, 3604], '1WDF)': [3333, 3605], 'search': [3336, 3609], 'model.': [3337, 3610], 'Rotation': [3338], 'translation': [3340, 3626], 'function': [3341, 3627], 'searches': [3342], 'program': [3347, 3555], 'CNS': [3348, 3426, 3556, 3665], '(39Brunger': [3349, 3427, 3557, 3666], 'A.T.': [3350, 3428, 3558, 3667], 'Adams': [3351, 3429, 3559, 3668], 'P.D.': [3352, 3430, 3560, 3669], 'DeLano': [3355, 3433, 3563, 3672], 'W.L.': [3356, 3434, 3564, 3673], 'Gros': [3357, 3435, 3565, 3674], 'Grosse-Kunstleve': [3359, 3437, 3567, 3676], 'Kuszewski': [3363, 3441, 3571, 3680], 'Nilges': [3365, 3443, 3573, 3682], 'Pannu': [3367, 3445, 3575, 3684], 'N.S.': [3368, 3446, 3576, 3685], 'Read': [3369, 3447, 3577, 3686], 'R.J.': [3370, 3448, 3578, 3687], 'Rice': [3371, 3449, 3579, 3688], 'L.M.': [3372, 3450, 3580, 3689], 'Simonson': [3373, 3451, 3581, 3690], 'Warren': [3375, 3453, 3583, 3692], 'G.L.': [3376, 3454, 3584, 3693], 'Acta': [3377, 3414, 3455, 3585, 3653, 3694], 'Crystallogr.': [3378, 3381, 3415, 3456, 3459, 3486, 3535, 3586, 3589, 3654, 3695, 3698], 'D': [3379, 3457, 3587, 3696], '54:': [3383, 3461, 3591, 3700], '905-921Crossref': [3384, 3462, 3592, 3701], '(16967)': [3387, 3465, 3595, 3704], 'improved': [3393, 3632], 'cycles': [3396, 3635], 'manual': [3398, 3637], 'building': [3399, 3638], 'refinement': [3401, 3640, 3749, 3759, 3808, 3853], 'O': [3405, 3644, 4410, 4441], '(40Jones': [3406, 3645], 'T.A.': [3407, 3646], 'Zou': [3408, 3647], 'Cowan': [3410, 3649], 'S.W.': [3411, 3650], 'Kjeldgaard': [3412, 3651], '1991;': [3417, 3507, 3536, 3656], '47:': [3418, 3657], '110-119Crossref': [3419, 3658], '(13011)': [3422, 3661], 'coordinates': [3471], 'examined': [3473], 'PROCHECK': [3475], '(41Laskowski': [3476], 'MacArthur': [3478], 'Moss': [3480], 'D.S.': [3481], 'Thornton': [3482], 'Appl.': [3485, 3534], '1993;': [3487], '26:': [3488], '283-291Crossref': [3489], 'figures': [3493], 'generated': [3495], 'GRASP': [3499], '(42Nicholls': [3500], 'Sharp': [3502], 'Honig': [3504], 'Proteins.': [3506], '11:': [3508], '281-296Crossref': [3509], '(5316)': [3512], 'SPDBView': [3515], '(43Guex': [3516], 'Peitsch': [3518], 'Electrophoresis.': [3520], '18:': [3522], '2714-2723Crossref': [3523], '(9590)': [3526], 'MOLSCRIPT': [3530], '(44Kraulis': [3531], '24:': [3537], '946-950Crossref': [3538], 'employed': [3606], 'Six': [3611], '(two': [3613], 'per': [3618], 'unit': [3620, 3887], 'located': [3622], 'crossrotation': [3624], 'searches.': [3628], 'subsequently': [3710], 'refined': [3711], 'final': [3714, 3758], 'resolution': [3715, 3768], 'R': [3721, 3796], 'value': [3722, 3727], '23.3%': [3724], 'Rfree': [3726, 3793], '27.3%.': [3729], 'No': [3730], 'residue': [3731, 4419], 'disallowed': [3734], 'Ramachandran': [3738], 'plot.': [3739], 'statistics': [3741, 3760], 'data': [3744], 'collection,': [3745], 'determination,': [3747], 'summarized': [3751], 'Table': [3753], 'I.Table': [3754], 'IData': [3755], 'Numbers': [3761], 'parentheses': [3763], 'correspond': [3764], 'highest': [3767], 'shell.': [3769], 'Rmerge': [3770], 'ΣhΣI|Iih': [3772], '–': [3773, 3791], '〈Ih〉|/ΣhΣI〈Ih〉,': [3774], 'where': [3775], '〈Ih〉': [3776], 'mean': [3779, 3818, 4666], 'observations': [3782], 'Iih': [3783], 'reflection': [3785], 'h.': [3786], 'Rwork': [3787], 'Σ': [3789], '(|Fobs|': [3790], '|Fcalc||)/Σ|Fobs|;': [3792], 'factor': [3797], 'subset': [3800], '(5%)': [3801], 'reflections': [3803, 3859, 3862, 3867], 'selected': [3806], 'before': [3807], 'calculations': [3809], 'included': [3812], 'refinement.': [3815], 'r.m.s.d.,': [3816], 'root': [3817, 4665], 'square': [3819, 4667], 'deviation': [3820], 'ideal': [3822], 'geometry.Data': [3823], 'statisticsSpace': [3825], 'groupC2Unit': [3826], 'cell': [3827], 'parametersa': [3828], '107.4°Wavelength': [3842], '(Å)1.5418Resolution': [3843], 'limit': [3844], '(Å)2.8Observed': [3845], 'reflections27,312Unique': [3846], 'reflections11,974Completeness': [3847], '(%)91.4': [3848], '(80.8)[I/σ(I)]5.7': [3849], '(1.2)Rmerge': [3850], '(%)13.9': [3851], 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