Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2012051201', 'doi': 'https://doi.org/10.1111/j.1572-0241.2005.50412.x', 'title': 'Quantitative Detection of Promoter Hypermethylation in Multiple Genes in the Serum of Patients with Colorectal Cancer', 'display_name': 'Quantitative Detection of Promoter Hypermethylation in Multiple Genes in the Serum of Patients with Colorectal Cancer', 'publication_year': 2005, 'publication_date': '2005-10-01', 'ids': {'openalex': 'https://openalex.org/W2012051201', 'doi': 'https://doi.org/10.1111/j.1572-0241.2005.50412.x', 'mag': '2012051201', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16181380'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1572-0241.2005.50412.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S66441642', 'display_name': 'The American Journal of Gastroenterology', 'issn_l': '0002-9270', 'issn': ['0002-9270', '1572-0241'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5052342507', 'display_name': 'Wai K. Leung', 'orcid': 'https://orcid.org/0000-0002-5993-1059'}, 'institutions': [{'id': 'https://openalex.org/I177725633', 'display_name': 'Chinese University of Hong Kong', 'ror': 'https://ror.org/00t33hh48', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177725633']}, {'id': 'https://openalex.org/I4210114914', 'display_name': 'Prince of Wales Hospital', 'ror': 'https://ror.org/02827ca86', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1294586568', 'https://openalex.org/I4210114914']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Wai K. Leung', 'raw_affiliation_strings': ['Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong', 'institution_ids': ['https://openalex.org/I177725633', 'https://openalex.org/I4210114914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050884242', 'display_name': 'Ka‐Fai To', 'orcid': 'https://orcid.org/0000-0003-4919-3707'}, 'institutions': [{'id': 'https://openalex.org/I177725633', 'display_name': 'Chinese University of Hong Kong', 'ror': 'https://ror.org/00t33hh48', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177725633']}, {'id': 'https://openalex.org/I4210114914', 'display_name': 'Prince of Wales Hospital', 'ror': 'https://ror.org/02827ca86', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1294586568', 'https://openalex.org/I4210114914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ka-Fai To', 'raw_affiliation_strings': ['Department of Anatomical & Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomical & Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong', 'institution_ids': ['https://openalex.org/I177725633', 'https://openalex.org/I4210114914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017040011', 'display_name': 'Ellen P.S. Man', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I177725633', 'display_name': 'Chinese University of Hong Kong', 'ror': 'https://ror.org/00t33hh48', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177725633']}, {'id': 'https://openalex.org/I4210114914', 'display_name': 'Prince of Wales Hospital', 'ror': 'https://ror.org/02827ca86', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1294586568', 'https://openalex.org/I4210114914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ellen P.S. Man', 'raw_affiliation_strings': ['Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong', 'institution_ids': ['https://openalex.org/I177725633', 'https://openalex.org/I4210114914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041975586', 'display_name': 'Michael W.Y. Chan', 'orcid': 'https://orcid.org/0000-0003-0314-2437'}, 'institutions': [{'id': 'https://openalex.org/I177725633', 'display_name': 'Chinese University of Hong Kong', 'ror': 'https://ror.org/00t33hh48', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177725633']}, {'id': 'https://openalex.org/I4210114914', 'display_name': 'Prince of Wales Hospital', 'ror': 'https://ror.org/02827ca86', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1294586568', 'https://openalex.org/I4210114914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Michael W.Y. Chan', 'raw_affiliation_strings': ['Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong', 'institution_ids': ['https://openalex.org/I177725633', 'https://openalex.org/I4210114914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021048872', 'display_name': 'Alfa H.C. Bai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I177725633', 'display_name': 'Chinese University of Hong Kong', 'ror': 'https://ror.org/00t33hh48', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177725633']}, {'id': 'https://openalex.org/I4210114914', 'display_name': 'Prince of Wales Hospital', 'ror': 'https://ror.org/02827ca86', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1294586568', 'https://openalex.org/I4210114914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Alfa H.C. Bai', 'raw_affiliation_strings': ['Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong', 'institution_ids': ['https://openalex.org/I177725633', 'https://openalex.org/I4210114914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088639791', 'display_name': 'Aric J. Hui', 'orcid': 'https://orcid.org/0000-0003-2150-5713'}, 'institutions': [{'id': 'https://openalex.org/I177725633', 'display_name': 'Chinese University of Hong Kong', 'ror': 'https://ror.org/00t33hh48', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177725633']}, {'id': 'https://openalex.org/I4210114914', 'display_name': 'Prince of Wales Hospital', 'ror': 'https://ror.org/02827ca86', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1294586568', 'https://openalex.org/I4210114914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Aric J. Hui', 'raw_affiliation_strings': ['Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong', 'institution_ids': ['https://openalex.org/I177725633', 'https://openalex.org/I4210114914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085313387', 'display_name': 'Francis K.L. Chan', 'orcid': 'https://orcid.org/0000-0001-7388-2436'}, 'institutions': [{'id': 'https://openalex.org/I4210114914', 'display_name': 'Prince of Wales Hospital', 'ror': 'https://ror.org/02827ca86', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1294586568', 'https://openalex.org/I4210114914']}, {'id': 'https://openalex.org/I177725633', 'display_name': 'Chinese University of Hong Kong', 'ror': 'https://ror.org/00t33hh48', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177725633']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Francis K.L. Chan', 'raw_affiliation_strings': ['Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong', 'institution_ids': ['https://openalex.org/I4210114914', 'https://openalex.org/I177725633']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5049274840', 'display_name': 'Joseph J.�Y. Sung', 'orcid': 'https://orcid.org/0000-0003-3125-5199'}, 'institutions': [{'id': 'https://openalex.org/I177725633', 'display_name': 'Chinese University of Hong Kong', 'ror': 'https://ror.org/00t33hh48', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177725633']}, {'id': 'https://openalex.org/I4210114914', 'display_name': 'Prince of Wales Hospital', 'ror': 'https://ror.org/02827ca86', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1294586568', 'https://openalex.org/I4210114914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Joseph J.Y. Sung', 'raw_affiliation_strings': ['Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong', 'institution_ids': ['https://openalex.org/I177725633', 'https://openalex.org/I4210114914']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5052342507'], 'corresponding_institution_ids': ['https://openalex.org/I177725633', 'https://openalex.org/I4210114914'], 'apc_list': None, 'apc_paid': None, 'fwci': 6.536, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 144, 'citation_normalized_percentile': {'value': 0.954952, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '100', 'issue': '10', 'first_page': '2274', 'last_page': '2279'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11369', 'display_name': 'Molecular Characterization of Colorectal Cancer', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11369', 'display_name': 'Molecular Characterization of Colorectal Cancer', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10552', 'display_name': 'Global Trends in Colorectal Cancer Research', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dna-methylation', 'display_name': 'DNA Methylation', 'score': 0.64866}, {'id': 'https://openalex.org/keywords/molecular-characterization', 'display_name': 'Molecular Characterization', 'score': 0.509935}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.95288163}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.8273686}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.5899157}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.5617561}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.53927636}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.4864671}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.40721348}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.39893025}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.17648122}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.16541725}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D017491', 'descriptor_name': 'Genes, APC', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005240', 'descriptor_name': 'Feasibility Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017491', 'descriptor_name': 'Genes, APC', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051549', 'descriptor_name': 'Glutathione S-Transferase pi', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005982', 'descriptor_name': 'Glutathione Transferase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005982', 'descriptor_name': 'Glutathione Transferase', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D005982', 'descriptor_name': 'Glutathione Transferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000070957', 'descriptor_name': 'MutL Protein Homolog 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012680', 'descriptor_name': 'Sensitivity and Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1572-0241.2005.50412.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S66441642', 'display_name': 'The American Journal of Gastroenterology', 'issn_l': '0002-9270', 'issn': ['0002-9270', '1572-0241'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16181380', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.79}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1633962291', 'https://openalex.org/W1658596276', 'https://openalex.org/W1939667038', 'https://openalex.org/W1987875441', 'https://openalex.org/W1996153528', 'https://openalex.org/W2002988323', 'https://openalex.org/W2004172747', 'https://openalex.org/W2040257851', 'https://openalex.org/W2057769740', 'https://openalex.org/W2058680827', 'https://openalex.org/W2062369431', 'https://openalex.org/W2084303694', 'https://openalex.org/W2097786984', 'https://openalex.org/W2098824335', 'https://openalex.org/W2106680700', 'https://openalex.org/W2133973332', 'https://openalex.org/W2142010436', 'https://openalex.org/W2147977885', 'https://openalex.org/W2149696676', 'https://openalex.org/W2164395088', 'https://openalex.org/W2167284467', 'https://openalex.org/W2179270878', 'https://openalex.org/W2323129829', 'https://openalex.org/W2334576825', 'https://openalex.org/W2341251078', 'https://openalex.org/W2883994748', 'https://openalex.org/W3159004246', 'https://openalex.org/W4253997817'], 'related_works': ['https://openalex.org/W4377092742', 'https://openalex.org/W4362606997', 'https://openalex.org/W4361825250', 'https://openalex.org/W4229447658', 'https://openalex.org/W3092304831', 'https://openalex.org/W2374019147', 'https://openalex.org/W2370262613', 'https://openalex.org/W2172237894', 'https://openalex.org/W2015369371', 'https://openalex.org/W1979814181'], 'abstract_inverted_index': {'OBJECTIVES': [0], 'While': [1], 'promoter': [2], 'hypermethylation': [3], 'is': [4], 'a': [5, 91, 146, 182, 202], 'common': [6], 'molecular': [7], 'alteration': [8], 'of': [9, 24, 27, 38, 47, 63, 97, 148, 152, 185, 194, 212], 'human': [10], 'colorectal': [11, 39, 49, 130, 213], 'cancer': [12, 40, 50, 102, 131, 166], 'that': [13], 'could': [14], 'be': [15, 201], 'detected': [16, 82, 138], 'in': [17, 31, 34, 66, 94, 139, 158, 174, 198], 'the': [18, 22, 35, 95, 207], 'bloodstream,': [19], 'we': [20], 'tested': [21], 'feasibility': [23], 'quantitative': [25, 84, 192], 'detection': [26, 193], 'aberrant': [28, 195], 'DNA': [29, 65, 100, 137, 196], 'methylation': [30, 157, 160, 173, 197], 'multiple': [32], 'genes': [33], 'serum': [36, 45, 99, 199], 'samples': [37, 46], 'patients.': [41], 'METHODS': [42], 'The': [43, 61, 191], 'pre-therapeutic': [44], '49': [48], 'patients': [51, 103, 128, 155, 171], 'and': [52, 76, 104, 111, 132, 150, 170, 210], '41': [53], 'age-matched': [54], 'controls': [55, 105, 134], 'with': [56, 129, 156, 172], 'normal': [57], 'colonoscopy': [58], 'were': [59], 'examined.': [60], 'presence': [62], 'methylated': [64, 98, 136], 'APC': [67, 120], '(adenomatous': [68], 'polyposis': [69], 'coli),': [70], 'hMLH1': [71, 112], '(human': [72], 'MutL': [73], 'homolog': [74], '1),': [75], 'HLTF': [77, 107], '(helicase-like': [78], 'transcription': [79], 'factor)': [80], 'was': [81, 90], 'by': [83], 'methylation-specific': [85], 'PCR': [86], '(MethyLight).': [87], 'RESULTS': [88], 'There': [89], 'significant': [92], 'difference': [93], 'concentration': [96], 'between': [101], 'for': [106, 119, 206], '(p': [108, 113, 122, 167, 187], '=': [109, 114, 123, 168, 188], '0.015)': [110], '0.0001)': [115], 'genes,': [116], 'but': [117], 'not': [118], 'gene': [121], '0.21).': [124], 'In': [125], 'total,': [126], '28': [127], '4': [133], 'had': [135, 162], 'at': [140, 175], 'least': [141, 176], 'one': [142, 177], 'marker,': [143], 'which': [144], 'gave': [145], 'sensitivity': [147], '57%': [149], 'specificity': [151], '90%.': [153], 'All': [154], 'two': [159], 'markers': [161], 'advanced': [163], '(stage': [164], 'III/IV)': [165], '0.006)': [169], 'marker': [178], 'tended': [179], 'to': [180], 'have': [181], 'lower': [183], 'probability': [184], 'survival': [186], '0.08).': [189], 'CONCLUSION': [190], 'may': [200], 'promising': [203], 'high-throughput': [204], 'approach': [205], 'noninvasive': [208], 'screening': [209], 'monitoring': [211], 'cancer.': [214]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2012051201', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 14}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2024-09-09T21:03:32.226936', 'created_date': '2016-06-24'}