Title: Relationship between alcohol preference and biogenic aldehyde metabolizing enzymes in rats
Abstract: Rats were presented water and alcohol solutions [up to 30 per cent (v/v)] in a free choice screening test. High drinkers ingested the equivalent of ca. 6 g/kg day of pure ethanol, at any concentration offered. Low drinkers consumed only ca. 2/kg. day, but stopped drinking alcohol solutions at concentrations higher than 7.5%. Males and females exhibited similar drinking habits. As measured by incubations of tissue slices and analysis of the components formed, high as well as low drinkers metabolize serotonin and dopamine at the same rate and produce identical metabolites. However, some small differences in the metabolism of these biogenic amines exist between males and females. The isozyme patterns of both aldehyde reductase (ALRed) and aldehyde dehydrogenase (ALDH) from the brain of high and low drinkers are identical. The levels of activity and isozymes of liver ALRed are the same, as are those of liver ALDH from the matrix of mitochondria which is responsible for the oxidation of acetaldehyde. Though the level of liver ALDH from the cytosol fraction is unaltered, the isozyme pattern is very different. Low drinkers always have three isozymes at pi 5.9, 6.0 and 6.2, while high drinkers have only one isozyme in this range, either at pi 5.9 or 6.2. Both animals have many more isozymes of the enzyme.
Publication Year: 1977
Publication Date: 1977-05-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 27
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