Title: Reaction of 6‐aminopyrimidin‐4‐ones with diethyl ethoxymethylenemalonate in several media: Synthesis of pyrido[2,3‐<i>d</i>]pyrimidines
Abstract: Abstract Reactions of 6‐amino‐3,4‐dihydro‐2‐methoxy‐4‐oxopyrimidine 1 and its 3‐methyl derivative 2 , with diethyl ethoxymethylenemalonate (EMME) are discussed in this paper. These reactions have been carried out in the following media: under fusion, ethanol, sodium methoxide/methanol, sodium ethoxide:ethanol and acetic acid media. In acetic medium, mixtures of products proceeding from C ‐alkylation and N ‐alkylation were obtained, while in the remaining conditions only products of N ‐alkylation were obtained.
Publication Year: 1989
Publication Date: 1989-07-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 9
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