Title: The effect of tableting on the release characteristics of naproxen and ibuprofen microcapsules
Abstract: Tablets were prepared from ethylcellulose walled naproxen and ibuprofen microcapsules. The naproxen and ibuprofen microcapsules were prepared by different methods; the naproxen microcapsules were coated drug crystals whereas ibuprofen microcapsules had a matrix structure. The microcapsules showed good compression behaviour and satisfactory tablets were produced. Release characteristics of the microcapsules changed drastically upon compression and the addition of excipients to the tablets decreased the t50%. The results also indicate that the ibuprofen microcapsules are intact after tableting whereas the coating on the naproxen microcapsules is ruptured to some extent.
Publication Year: 1993
Publication Date: 1993-05-03
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
Cited By Count: 15
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