Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2011821088', 'doi': 'https://doi.org/10.1093/nar/25.20.4035', 'title': 'Functional modulation of estrogen receptor by redox state with reference to thioredoxin as a mediator', 'display_name': 'Functional modulation of estrogen receptor by redox state with reference to thioredoxin as a mediator', 'publication_year': 1997, 'publication_date': '1997-10-15', 'ids': {'openalex': 'https://openalex.org/W2011821088', 'doi': 'https://doi.org/10.1093/nar/25.20.4035', 'mag': '2011821088', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9321654', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/146993'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/25.20.4035', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/25/20/4035/6241501/25-20-4035.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/nar/article-pdf/25/20/4035/6241501/25-20-4035.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111630341', 'display_name': 'Shin‐ichi Hayashi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210123465', 'display_name': 'Saitama Cancer Center', 'ror': 'https://ror.org/03a4d7t12', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210123465']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shin-ichi Hayashi', 'raw_affiliation_strings': ['Department of Biochemistry, Saitama Cancer Center Research Institute, Komuro, Ina, Saitama 362, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Saitama Cancer Center Research Institute, Komuro, Ina, Saitama 362, Japan.', 'institution_ids': ['https://openalex.org/I4210123465']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067540175', 'display_name': 'Kyoko Hajiro-Nakanishi', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Kyoko Hajiro-Nakanishi', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089032322', 'display_name': 'Yuichi Makino', 'orcid': 'https://orcid.org/0000-0002-9566-5069'}, 'institutions': [{'id': 'https://openalex.org/I127036137', 'display_name': 'Asahikawa Medical College Hospital', 'ror': 'https://ror.org/00ftrxq20', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I127036137']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuichi Makino', 'raw_affiliation_strings': ['Second Department of Internal Medicine, Asahikawa Medical College, Asahikawa 078 Japan'], 'affiliations': [{'raw_affiliation_string': 'Second Department of Internal Medicine, Asahikawa Medical College, Asahikawa 078 Japan', 'institution_ids': ['https://openalex.org/I127036137']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022184356', 'display_name': 'Hidetaka Eguchi', 'orcid': 'https://orcid.org/0000-0002-0300-3587'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hidetaka Eguchi', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016294535', 'display_name': 'Junji Yodoi', 'orcid': 'https://orcid.org/0000-0001-6849-4914'}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Junji Yodoi', 'raw_affiliation_strings': ['Department of Biological Responses, Institute for Virus Research, Kyoto University, Shogoin-Kawaracho, Sakyo-Ku, Kyoto 660, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Responses, Institute for Virus Research, Kyoto University, Shogoin-Kawaracho, Sakyo-Ku, Kyoto 660, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5006839036', 'display_name': 'Hirotoshi Tanaka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I127036137', 'display_name': 'Asahikawa Medical College Hospital', 'ror': 'https://ror.org/00ftrxq20', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I127036137']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hirotoshi Tanaka', 'raw_affiliation_strings': ['Second Department of Internal Medicine, Asahikawa Medical College, Asahikawa 078 Japan'], 'affiliations': [{'raw_affiliation_string': 'Second Department of Internal Medicine, Asahikawa Medical College, Asahikawa 078 Japan', 'institution_ids': ['https://openalex.org/I127036137']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3630, 'currency': 'USD', 'value_usd': 3630, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 5.407, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 133, 'citation_normalized_percentile': {'value': 0.885263, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '25', 'issue': '20', 'first_page': '4035', 'last_page': '4040'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11332', 'display_name': 'Genomics, phytochemicals, and oxidative stress', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11884', 'display_name': 'Redox biology and oxidative stress', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/estrogen-receptor-beta', 'display_name': 'Estrogen receptor beta', 'score': 0.48957738}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.79580927}, {'id': 'https://openalex.org/C3623737', 'wikidata': 'https://www.wikidata.org/wiki/Q421219', 'display_name': 'Thioredoxin', 'level': 3, 'score': 0.75519633}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.6710427}, {'id': 'https://openalex.org/C84606932', 'wikidata': 'https://www.wikidata.org/wiki/Q416496', 'display_name': 'Estrogen receptor', 'level': 4, 'score': 0.6068382}, {'id': 'https://openalex.org/C51785407', 'wikidata': 'https://www.wikidata.org/wiki/Q2627568', 'display_name': 'Effector', 'level': 2, 'score': 0.5506251}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5145773}, {'id': 'https://openalex.org/C96307122', 'wikidata': 'https://www.wikidata.org/wiki/Q15329133', 'display_name': 'Estrogen receptor beta', 'level': 5, 'score': 0.48957738}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.4894251}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.43629694}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2803246}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.13165337}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.09812412}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D011960', 'descriptor_name': 'Receptors, Estrogen', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D011960', 'descriptor_name': 'Receptors, Estrogen', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D013879', 'descriptor_name': 'Thioredoxins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001667', 'descriptor_name': 'Binding, Competitive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015500', 'descriptor_name': 'Chloramphenicol O-Acetyltransferase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015500', 'descriptor_name': 'Chloramphenicol O-Acetyltransferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006861', 'descriptor_name': 'Hydrogen Peroxide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006861', 'descriptor_name': 'Hydrogen Peroxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015345', 'descriptor_name': 'Oligonucleotide Probes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015345', 'descriptor_name': 'Oligonucleotide Probes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010084', 'descriptor_name': 'Oxidation-Reduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016133', 'descriptor_name': 'Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011960', 'descriptor_name': 'Receptors, Estrogen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013879', 'descriptor_name': 'Thioredoxins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013879', 'descriptor_name': 'Thioredoxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/25.20.4035', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/25/20/4035/6241501/25-20-4035.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc146993', 'pdf_url': 'https://europepmc.org/articles/pmc146993?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC146993', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9321654', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/25.20.4035', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/25/20/4035/6241501/25-20-4035.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.81, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W136128967', 'https://openalex.org/W1501442799', 'https://openalex.org/W1504064499', 'https://openalex.org/W1517639918', 'https://openalex.org/W1565745037', 'https://openalex.org/W1577403013', 'https://openalex.org/W1614283262', 'https://openalex.org/W1820869110', 'https://openalex.org/W1842535138', 'https://openalex.org/W1907965198', 'https://openalex.org/W1914476337', 'https://openalex.org/W1915418979', 'https://openalex.org/W1949973946', 'https://openalex.org/W1953237114', 'https://openalex.org/W1978029697', 'https://openalex.org/W1979317853', 'https://openalex.org/W1981306061', 'https://openalex.org/W1981771606', 'https://openalex.org/W1982925298', 'https://openalex.org/W1984355175', 'https://openalex.org/W1985448020', 'https://openalex.org/W2002931771', 'https://openalex.org/W2015538958', 'https://openalex.org/W2018579779', 'https://openalex.org/W2022842120', 'https://openalex.org/W2035022316', 'https://openalex.org/W2040071780', 'https://openalex.org/W2060903877', 'https://openalex.org/W2064280448', 'https://openalex.org/W2070693959', 'https://openalex.org/W2072787342', 'https://openalex.org/W2073704044', 'https://openalex.org/W2085124463', 'https://openalex.org/W2089362925', 'https://openalex.org/W2095585565', 'https://openalex.org/W2120148677', 'https://openalex.org/W2124813625', 'https://openalex.org/W2134812217', 'https://openalex.org/W2172271037', 'https://openalex.org/W2415763315', 'https://openalex.org/W4247896860', 'https://openalex.org/W8163034', 'https://openalex.org/W988818877'], 'related_works': ['https://openalex.org/W3030675007', 'https://openalex.org/W2469032521', 'https://openalex.org/W2386098162', 'https://openalex.org/W2358723699', 'https://openalex.org/W2351953623', 'https://openalex.org/W2122907454', 'https://openalex.org/W2059724651', 'https://openalex.org/W2010111362', 'https://openalex.org/W1995664118', 'https://openalex.org/W1981527924'], 'abstract_inverted_index': {'Redox': [0], 'regulation': [1, 37], 'of': [2, 31, 38, 41, 47, 51, 60, 71, 77, 81, 87, 96, 103, 116, 124, 145, 158, 179], 'transcription': [3, 177], 'factors': [4], 'has': [5], 'recently': [6], 'been': [7], 'demonstrated': [8], 'for': [9, 45], 'AP-1,': [10], 'NF-κB,': [11], 'Sp-1': [12], 'and': [13, 18, 35, 49, 58, 85, 106, 131, 153, 171], 'glucocorticoid': [14], 'receptor': [15, 33], 'in': [16, 19, 24, 79, 90, 162, 169, 172], 'vitro': [17, 170], 'vivo.': [20], 'The': [21], 'redox': [22, 72, 186, 194], 'state': [23, 73], 'estrogen-dependent': [25], 'cells': [26], 'possibly': [27], 'influences': [28], 'the': [29, 36, 39, 69, 122, 132, 156, 176], 'function': [30, 40], 'estrogen': [32], '(ER),': [34], 'ER': [42, 78, 147, 180], 'is': [43, 181, 189], 'essential': [44], 'understanding': [46], 'growth': [48], 'differentiation': [50], 'these': [52], 'cells,': [53], 'as': [54, 56], 'well': [55], 'promotion': [57], 'progression': [59], 'estrogen-associated': [61], 'cancer.': [62], 'In': [63], 'this': [64], 'paper,': [65], 'we': [66], 'first': [67], 'analyzed': [68], 'effects': [70], 'on': [74], 'transcriptional': [75], 'activity': [76, 133, 144, 178], 'terms': [80], 'pS2': [82, 104], 'mRNA': [83, 105], 'expression': [84, 119], 'transfection': [86, 115, 123], 'ERE-CAT': [88, 109, 129], 'plasmid': [89, 127], 'human': [91], 'breast': [92], 'cancer': [93], 'cells.': [94], 'Addition': [95], 'H2O2': [97], 'at': [98], 'low': [99], 'concentrations': [100], 'lowered': [101], 'levels': [102], 'also': [107], 'down-regulated': [108], 'activity,': [110, 130], 'which': [111, 188], 'was': [112, 134, 148], 'recovered': [113, 135], 'by': [114, 136, 150, 155, 184, 192], 'thioredoxin': [117], '(TRX)': [118], 'vector.': [120], 'Next,': [121], 'antisense': [125], 'TRX': [126, 160], 'diminished': [128], 'co-transfected': [137], 'sense': [138], 'TRX.': [139, 197], 'Furthermore,': [140], 'specific': [141], 'DNA': [142], 'binding': [143], 'recombinant': [146, 159], 'inhibited': [149], 'sulfhydryl-modifying': [151], 'reagents': [152], 'restored': [154], 'addition': [157], 'protein': [161], 'electrophoretic': [163], 'mobility': [164], 'shift': [165], 'assay.': [166], 'These': [167], 'results': [168], 'vivo': [173], 'revealed': [174], 'that': [175], 'strongly': [182], 'influenced': [183], 'its': [185], 'state,': [187], 'reversibly': [190], 'modulated': [191], 'endogenous': [193], 'effector': [195], 'protein,': [196]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2011821088', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-13T17:04:14.791248', 'created_date': '2016-06-24'}