Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2011771880', 'doi': 'https://doi.org/10.1128/jvi.80.8.4017-4025.2006', 'title': 'Envelope Conformational Changes Induced by Human Immunodeficiency Virus Type 1 Attachment Inhibitors Prevent CD4 Binding and Downstream Entry Events', 'display_name': 'Envelope Conformational Changes Induced by Human Immunodeficiency Virus Type 1 Attachment Inhibitors Prevent CD4 Binding and Downstream Entry Events', 'publication_year': 2006, 'publication_date': '2006-03-29', 'ids': {'openalex': 'https://openalex.org/W2011771880', 'doi': 'https://doi.org/10.1128/jvi.80.8.4017-4025.2006', 'mag': '2011771880', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16571818', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1440438'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jvi.80.8.4017-4025.2006', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1128/jvi.80.8.4017-4025.2006', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5109191435', 'display_name': 'Hsu‐Tso Ho', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hsu-Tso Ho', 'raw_affiliation_strings': ['Departments of Virology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Virology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100373585', 'display_name': 'Fan Li', 'orcid': 'https://orcid.org/0000-0002-8895-2473'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Li Fan', 'raw_affiliation_strings': ['Departments of Virology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Virology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038163293', 'display_name': 'Beata Nowicka-Sans', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Beata Nowicka-Sans', 'raw_affiliation_strings': ['Departments of Virology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Virology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045523688', 'display_name': 'Brian McAuliffe', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Brian McAuliffe', 'raw_affiliation_strings': ['Departments of Virology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Virology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001908149', 'display_name': 'Changben Li', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Chang-Ben Li', 'raw_affiliation_strings': ['Departments of Virology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Virology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060214966', 'display_name': 'Gregory Yamanaka', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Gregory Yamanaka', 'raw_affiliation_strings': ['Departments of Virology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Virology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082613080', 'display_name': 'Nannan Zhou', 'orcid': 'https://orcid.org/0000-0001-9085-4373'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Nannan Zhou', 'raw_affiliation_strings': ['Departments of Virology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Virology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100646825', 'display_name': 'Fang Hua', 'orcid': 'https://orcid.org/0000-0003-2465-4888'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hua Fang', 'raw_affiliation_strings': ['Departments of Virology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Virology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051197371', 'display_name': 'Ira B. Dicker', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ira Dicker', 'raw_affiliation_strings': ['Departments of Virology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Virology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067481706', 'display_name': 'R. A. Dalterio', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210091812', 'display_name': 'Bristol-Myers Squibb (United States)', 'ror': 'https://ror.org/00gtmwv55', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210091812']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard Dalterio', 'raw_affiliation_strings': ['Analytical Chemistry, Bristol Myers-Squibb, Wallingford, Connecticut 06492'], 'affiliations': [{'raw_affiliation_string': 'Analytical Chemistry, Bristol Myers-Squibb, Wallingford, Connecticut 06492', 'institution_ids': ['https://openalex.org/I4210091812']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036878791', 'display_name': 'Yi-Fei Gong', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yi-Fei Gong', 'raw_affiliation_strings': ['Departments of Virology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Virology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100453556', 'display_name': 'Tao Wang', 'orcid': 'https://orcid.org/0000-0002-5866-8148'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Tao Wang', 'raw_affiliation_strings': ['Chemistry'], 'affiliations': [{'raw_affiliation_string': 'Chemistry', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101554761', 'display_name': 'Zhiwei Yin', 'orcid': 'https://orcid.org/0000-0002-4545-1783'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Zhiwei Yin', 'raw_affiliation_strings': ['Chemistry'], 'affiliations': [{'raw_affiliation_string': 'Chemistry', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113599045', 'display_name': 'Yasutsugu Ueda', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yasutsugu Ueda', 'raw_affiliation_strings': ['Chemistry'], 'affiliations': [{'raw_affiliation_string': 'Chemistry', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032021308', 'display_name': 'John D. Matiskella', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'John Matiskella', 'raw_affiliation_strings': ['Chemistry'], 'affiliations': [{'raw_affiliation_string': 'Chemistry', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050915947', 'display_name': 'John F. Kadow', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'John Kadow', 'raw_affiliation_strings': ['Chemistry'], 'affiliations': [{'raw_affiliation_string': 'Chemistry', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076252563', 'display_name': 'Paul R. Clapham', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I166722992', 'display_name': 'University of Massachusetts Chan Medical School', 'ror': 'https://ror.org/0464eyp60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I166722992']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paul Clapham', 'raw_affiliation_strings': ['Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605'], 'affiliations': [{'raw_affiliation_string': 'Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605', 'institution_ids': ['https://openalex.org/I166722992']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103129832', 'display_name': 'James E. Robinson', 'orcid': 'https://orcid.org/0000-0002-9215-9523'}, 'institutions': [{'id': 'https://openalex.org/I114832834', 'display_name': 'Tulane University', 'ror': 'https://ror.org/04vmvtb21', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114832834']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James Robinson', 'raw_affiliation_strings': ['Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana 70112'], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana 70112', 'institution_ids': ['https://openalex.org/I114832834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036974423', 'display_name': 'Richard J. Colonno', 'orcid': 'https://orcid.org/0000-0001-5381-3716'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Richard Colonno', 'raw_affiliation_strings': ['Departments of Virology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Virology', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5019963426', 'display_name': 'Pin-Fang Lin', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'Pin-Fang Lin', 'raw_affiliation_strings': ['Departments of Virology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Virology', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5019963426'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.648, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 110, 'citation_normalized_percentile': {'value': 0.936282, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '80', 'issue': '8', 'first_page': '4017', 'last_page': '4025'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10526', 'display_name': 'HIV/AIDS drug development and treatment', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10082', 'display_name': 'HIV/AIDS Research and Interventions', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/conformational-change', 'display_name': 'Conformational change', 'score': 0.5547086}, {'id': 'https://openalex.org/keywords/entry-inhibitor', 'display_name': 'Entry inhibitor', 'score': 0.42148787}], 'concepts': [{'id': 'https://openalex.org/C107824862', 'wikidata': 'https://www.wikidata.org/wiki/Q616005', 'display_name': 'Binding site', 'level': 2, 'score': 0.64323604}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.64305353}, {'id': 'https://openalex.org/C58475186', 'wikidata': 'https://www.wikidata.org/wiki/Q4118894', 'display_name': 'Viral entry', 'level': 4, 'score': 0.5998574}, {'id': 'https://openalex.org/C2776258796', 'wikidata': 'https://www.wikidata.org/wiki/Q5590520', 'display_name': 'Gp41', 'level': 4, 'score': 0.5958378}, {'id': 'https://openalex.org/C2777339483', 'wikidata': 'https://www.wikidata.org/wiki/Q647203', 'display_name': 'Conformational change', 'level': 2, 'score': 0.5547086}, {'id': 'https://openalex.org/C51639874', 'wikidata': 'https://www.wikidata.org/wiki/Q167149', 'display_name': 'Plasma protein binding', 'level': 2, 'score': 0.5209502}, {'id': 'https://openalex.org/C97380033', 'wikidata': 'https://www.wikidata.org/wiki/Q994215', 'display_name': 'Viral envelope', 'level': 3, 'score': 0.47711614}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.46038294}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.42538983}, {'id': 'https://openalex.org/C2776997796', 'wikidata': 'https://www.wikidata.org/wiki/Q1345259', 'display_name': 'Entry inhibitor', 'level': 5, 'score': 0.42148787}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.3335681}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.30812985}, {'id': 'https://openalex.org/C140704245', 'wikidata': 'https://www.wikidata.org/wiki/Q3933202', 'display_name': 'Viral replication', 'level': 3, 'score': 0.2757864}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.24917027}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.2370821}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.109831125}, {'id': 'https://openalex.org/C195616568', 'wikidata': 'https://www.wikidata.org/wiki/Q128711', 'display_name': 'Epitope', 'level': 3, 'score': 0.0790945}], 'mesh': [{'descriptor_ui': 'D019380', 'descriptor_name': 'Anti-HIV Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015704', 'descriptor_name': 'CD4 Antigens', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015699', 'descriptor_name': 'HIV Envelope Protein gp120', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D019380', 'descriptor_name': 'Anti-HIV Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015704', 'descriptor_name': 'CD4 Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015699', 'descriptor_name': 'HIV Envelope Protein gp120', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015699', 'descriptor_name': 'HIV Envelope Protein gp120', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019289', 'descriptor_name': 'Pyruvic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014771', 'descriptor_name': 'Virion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014771', 'descriptor_name': 'Virion', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jvi.80.8.4017-4025.2006', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1440438', 'pdf_url': 'https://europepmc.org/articles/pmc1440438?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1440438', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16571818', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jvi.80.8.4017-4025.2006', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.83, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1490369813', 'https://openalex.org/W1926800398', 'https://openalex.org/W1948737260', 'https://openalex.org/W1963530308', 'https://openalex.org/W1967972208', 'https://openalex.org/W1971099435', 'https://openalex.org/W1974543288', 'https://openalex.org/W1975606209', 'https://openalex.org/W1994030446', 'https://openalex.org/W1995355944', 'https://openalex.org/W1997989849', 'https://openalex.org/W1999350466', 'https://openalex.org/W2002944156', 'https://openalex.org/W2004714646', 'https://openalex.org/W2021445133', 'https://openalex.org/W2023888193', 'https://openalex.org/W2027738518', 'https://openalex.org/W2027812093', 'https://openalex.org/W2032020323', 'https://openalex.org/W2035844515', 'https://openalex.org/W2047819393', 'https://openalex.org/W2051073016', 'https://openalex.org/W2051731457', 'https://openalex.org/W2054399251', 'https://openalex.org/W2056150433', 'https://openalex.org/W2086783015', 'https://openalex.org/W2087272863', 'https://openalex.org/W2095632120', 'https://openalex.org/W2095939962', 'https://openalex.org/W2096649016', 'https://openalex.org/W2098781795', 'https://openalex.org/W2099381548', 'https://openalex.org/W2099749788', 'https://openalex.org/W2110838631', 'https://openalex.org/W2131903471', 'https://openalex.org/W2147469910', 'https://openalex.org/W2149138461', 'https://openalex.org/W2152489874', 'https://openalex.org/W2157615131', 'https://openalex.org/W2167847393', 'https://openalex.org/W2168357995', 'https://openalex.org/W2322382738', 'https://openalex.org/W2397879788', 'https://openalex.org/W2990127687', 'https://openalex.org/W4211151736', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W2564058179', 'https://openalex.org/W2534074565', 'https://openalex.org/W2157615131', 'https://openalex.org/W2094214456', 'https://openalex.org/W2058065096', 'https://openalex.org/W2031720554', 'https://openalex.org/W2011771880', 'https://openalex.org/W2003422665', 'https://openalex.org/W1987846451', 'https://openalex.org/W1963861214'], 'abstract_inverted_index': {'BMS-488043': [0, 35, 66, 86, 102, 142, 171, 200], 'is': [1, 120], 'a': [2, 183, 224], 'small-molecule': [3], 'human': [4], 'immunodeficiency': [5], 'virus': [6, 196], 'type': [7], '1': [8], '(HIV-1)': [9], 'CD4': [10, 21, 136, 155, 176, 212], 'attachment': [11], 'inhibitor': [12], 'with': [13, 77, 132], 'demonstrated': [14], 'clinical': [15], 'efficacy.': [16], 'The': [17], 'compound': [18, 127, 130], 'inhibits': [19, 201], 'soluble': [20], '(sCD4)': [22], 'binding': [23, 54, 63, 72, 100, 158, 177], 'to': [24, 40, 73, 109, 146, 178], 'the': [25, 53, 56, 60, 81, 88, 92, 121, 154, 194, 207], '11': [26], 'distinct': [27], 'HIV': [28, 180], 'envelope': [29, 69, 133, 185, 208], 'gp120': [30, 41, 62, 151, 189], 'proteins': [31], 'surveyed.': [32], 'Binding': [33], 'of': [34, 38, 48, 55, 91, 117, 125, 226], 'and': [36, 85, 128, 156, 166, 187, 210, 214], 'that': [37, 115, 129], 'sCD4': [39], 'are': [42], 'mutually': [43], 'exclusive,': [44], 'since': [45], 'increased': [46], 'concentrations': [47], 'one': [49], 'can': [50], 'completely': [51], 'block': [52], 'other': [57, 215], 'without': [58], 'affecting': [59], 'maximal': [61], 'capacity.': [64], 'Similarly,': [65], 'inhibited': [67, 222], 'virion': [68, 99], 'trimers': [70], 'from': [71], 'sCD4-immunoglobulin': [74], 'G': [75], '(IgG),': [76], 'decreasing': [78], 'inhibition': [79, 123], 'as': [80, 223], 'sCD4-IgG': [82], 'concentration': [83], 'increased,': [84], 'blocked': [87], 'sCD4-induced': [89], 'exposure': [90], 'gp41': [93], 'groove': [94], 'in': [95, 152], 'virions.': [96], 'In': [97], 'both': [98, 153], 'assays,': [101], 'was': [103, 143], 'active': [104], 'only': [105, 173], 'when': [106], 'added': [107], 'prior': [108], 'sCD4.': [110], 'Collectively,': [111], 'these': [112, 227], 'results': [113], 'indicate': [114], 'obstruction': [116], 'gp120-sCD4': [118], 'interactions': [119, 165], 'primary': [122], 'mechanism': [124], 'this': [126], 'interaction': [131], 'must': [134], 'precede': [135], 'binding.': [137], 'By': [138], 'three': [139], 'independent': [140], 'approaches,': [141], 'further': [144], 'shown': [145], 'induce': [147], 'conformational': [148, 229], 'changes': [149, 161], 'within': [150], 'CCR5': [157], 'regions.': [159], 'These': [160], 'likely': [162], 'prevent': [163], 'gp120-CD4': [164], 'downstream': [167, 216], 'entry': [168, 203, 217], 'events.': [169], 'However,': [170], 'could': [172, 219], 'partially': [174], 'inhibit': [175], 'an': [179], 'variant': [181], 'containing': [182], 'specific': [184], 'truncation': [186], 'altered': [188], 'conformation,': [190], 'despite': [191], 'effectively': [192], 'inhibiting': [193], 'pseudotyped': [195], 'infection.': [197], 'Taken': [198], 'together,': [199], 'viral': [202], 'primarily': [204], 'through': [205], 'altering': [206], 'conformation': [209], 'preventing': [211], 'binding,': [213], 'events': [218], 'also': [220], 'be': [221], 'result': [225], 'induced': [228], 'changes.': [230]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2011771880', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 13}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-12-12T21:29:10.963852', 'created_date': '2016-06-24'}