Title: Synthesis of New 4(3<i>H</i>)-Quinazolinone Derivatives by Reaction of 3-Amino-2(1<i>H</i>)-thioxo-4(3<i>H</i>)-quinazolinone with Selected Chloroformates: Ammonolysis of 3-Ethoxycarbonylamino-2-ethoxycarbonylthio-4(3<i>h</i>)-quinazolinone, Part 2<sup>1</sup>
Abstract: A series of N- and S-alkylated 4(3H)-quinazolinone derivatives ( 2 – 6 ) have been synthesized by the reaction of 3-amino-2(1H)-thioxo-4(3H)-quinazolinone ( 1 ) with selected chloroformates. 3-Ethoxycarbonylamino-2-ethoxycarbonylthio-4(3H)-quinazolinone ( 3 ) was ammonolysed using ammonia, primary or secondary amines. Depending on the kind of substrates and conditions of ammonolysis, products of various chemical structures were obtained. The products % 2–17 were identified by the results of elemental analysis and by their IR, 1H NMR, and mass spectra.
Publication Year: 2009
Publication Date: 2009-02-03
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 3
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