Publication Information

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'https://openalex.org/W1998203703', 'https://openalex.org/W1969771092', 'https://openalex.org/W184057646'], 'abstract_inverted_index': {'Oncogenes': [0, 232], 'enhance': [1, 233, 4804], 'the': [2, 20, 26, 31, 48, 121, 155, 164, 171, 234, 252, 258, 263, 280, 353, 387, 396, 403, 530, 717, 729, 733, 737, 769, 985, 1039, 1119, 1210, 1226, 1416, 1488, 1694, 1700, 1718, 1829, 2037, 2179, 2185, 2195, 2357, 2365, 2459, 2481, 2512, 2574, 2841, 2848, 2854, 2870, 2873, 2940, 2952, 2996, 3008, 3026, 3115, 3121, 3156, 3166, 3215, 3226, 3233, 3259, 3266, 3290, 3296, 3300, 3303, 3310, 3326, 3528, 3723, 3736, 3772, 3778, 3796, 3805, 3813, 3863, 3879, 4060, 4090, 4093, 4103, 4106, 4112, 4118, 4141, 4151, 4157, 4165, 4172, 4267, 4323, 4347, 4358, 4368, 4371, 4377, 4388, 4404, 4458, 4571, 4687, 4697, 4700, 4707, 4777, 4805, 4854, 4892, 4901, 4920, 4923, 4954, 4973, 5001, 5083, 5127, 5148, 5151, 5157, 5260, 5274, 5389, 5394, 5401, 5426, 5437, 5461], 'expression': [3, 235, 1120, 1489, 1719, 2727, 2779, 3779, 3971, 3991, 4006, 4182, 4405, 4431, 4460, 4683, 4904, 4924, 4955], 'of': [4, 28, 33, 79, 89, 110, 120, 152, 157, 203, 220, 236, 260, 265, 311, 321, 342, 352, 384, 389, 435, 452, 467, 532, 716, 736, 793, 989, 996, 1041, 1088, 1095, 1121, 1212, 1228, 1354, 1409, 1415, 1490, 1493, 1572, 1583, 1702, 1720, 1734, 1748, 1996, 2187, 2191, 2224, 2389, 2511, 2602, 2653, 2718, 2744, 2750, 2799, 2833, 2872, 2894, 2949, 2995, 3072, 3078, 3114, 3210, 3217, 3228, 3232, 3250, 3261, 3269, 3274, 3289, 3305, 3313, 3320, 3328, 3337, 3524, 3531, 3596, 3614, 3725, 3731, 3738, 3758, 3760, 3774, 3780, 3795, 3843, 3870, 3904, 3956, 3970, 3985, 3990, 4000, 4005, 4018, 4062, 4075, 4092, 4105, 4143, 4156, 4167, 4269, 4284, 4288, 4316, 4322, 4353, 4370, 4379, 4382, 4390, 4406, 4429, 4439, 4453, 4461, 4573, 4684, 4689, 4702, 4709, 4779, 4807, 4847, 4856, 4903, 4905, 4925, 4928, 4932, 4948, 4956, 4960, 5005, 5074, 5085, 5087, 5121, 5129, 5147, 5159, 5172, 5259, 5276, 5396, 5439], 'cyclooxygenase': [5, 237, 468], '(Cox)-2,': [6, 238], 'but': [7, 100, 133, 239, 332, 365, 1209, 3331, 3346, 4414, 4972, 5442], 'interactions': [8, 208, 240, 440, 4184, 4261, 5285], 'between': [9, 209, 241, 441, 1737, 3161, 3172, 3746, 4262, 4699, 4922, 5398, 5421, 5431], 'tumor': [10, 242, 1213, 1426, 4863, 4950], 'suppressor': [11, 243, 1214, 4951], 'genes': [12, 244, 718, 739, 1495, 4952], 'and': [13, 30, 92, 211, 227, 245, 262, 324, 443, 459, 599, 721, 789, 987, 1084, 1231, 1419, 1425, 1594, 1739, 1757, 1769, 1781, 1816, 1855, 1869, 1921, 1927, 1975, 2093, 2117, 2126, 2402, 2415, 2431, 2452, 2472, 2487, 2496, 2532, 2568, 2583, 2595, 2604, 2621, 2630, 2677, 2695, 2699, 2708, 2807, 2858, 2879, 3034, 3102, 3120, 3381, 3412, 3565, 3609, 4010, 4264, 4290, 4651, 4704, 4803, 4861, 4910, 4930, 5400, 5403, 5423, 5433, 5456], 'Cox-2': [14, 29, 90, 111, 122, 158, 192, 212, 221, 246, 261, 322, 343, 354, 390, 424, 444, 453, 543, 582, 772, 783, 982, 1045, 1089, 1122, 1219, 1740, 1749, 2451, 2619, 2697, 2700, 3000, 3251, 3306, 3314, 3321, 3338, 3429, 3532, 3607, 3762, 3789, 3797, 3829, 3844, 3859, 3905, 3957, 4077, 4107, 4173, 4292, 4407, 4430, 4440, 4462, 4574, 4685, 4710, 4933, 5006, 5030, 5040, 5075, 5160, 5405, 5440], 'have': [15, 24, 247, 256, 1698], 'not': [16, 42, 101, 248, 274, 333, 1727, 3207, 3257, 3282, 3332, 3347, 3897, 4313, 4331, 4386, 4397, 4415, 4979], 'been': [17, 249, 4177], 'studied.': [18, 250], 'In': [19, 251, 1351, 1693, 1722, 3263, 3819, 3883, 4277, 5388], 'present': [21, 253, 1695, 4400, 4893], 'work,': [22, 254, 1696], 'we': [23, 255, 1697, 3308, 3754, 4280], 'compared': [25, 82, 144, 257, 314, 376, 3811, 4116], 'levels': [27, 219, 259, 451, 1733, 1747, 2190, 3227, 3260, 3312, 3724, 4438, 5086], 'production': [32, 264, 3209, 4806, 5128], 'prostaglandin': [34, 80, 266, 312, 486, 515, 3218], 'E2': [35, 81, 267, 313], 'in': [36, 77, 113, 128, 139, 224, 229, 268, 309, 345, 360, 371, 456, 461, 725, 728, 732, 775, 786, 790, 992, 1225, 1598, 1717, 1732, 1753, 1759, 2123, 2128, 2397, 2418, 2469, 2480, 2493, 2528, 2534, 2570, 2585, 2633, 2685, 2804, 2815, 2951, 3009, 3075, 3134, 3182, 3225, 3287, 3302, 3325, 3342, 3618, 3722, 3735, 3751, 3764, 3776, 3804, 3828, 3849, 3858, 3862, 3878, 4083, 4111, 4129, 4136, 4266, 4444, 4466, 4676, 4696, 4934, 5007, 5124, 5269, 5407, 5448], 'mouse': [37, 269, 2999], 'embryo': [38, 270, 1940], 'fibroblasts': [39, 271], 'that': [40, 180, 207, 272, 412, 439, 589, 771, 782, 1118, 1581, 1710, 2087, 3145, 3185, 3197, 3242, 3605, 4065, 4126, 4140, 4345, 4403, 4463, 4845, 5153, 5174], 'do': [41, 273], 'express': [43, 275], 'any': [44, 276, 3288], 'p53': [45, 58, 64, 71, 99, 132, 143, 153, 181, 210, 277, 290, 296, 303, 331, 364, 375, 385, 413, 442, 1222, 1357, 1410, 1482, 1573, 1586, 1703, 1712, 1725, 1738, 2039, 2085, 2725, 2956, 3189, 3205, 3244, 3255, 3271, 3330, 3334, 3526, 3775, 3810, 3822, 3838, 3877, 3887, 3900, 3975, 4012, 4147, 4175, 4263, 4413, 4434, 4454, 4690, 4703, 4852, 4929, 4963, 5155, 5168, 5272, 5392, 5422, 5434], '((10)1)': [46, 278], 'versus': [47, 279], 'same': [49, 281, 2482, 3880], 'cell': [50, 282, 1417, 1601, 1942, 1989, 1998, 2119, 2148, 2374, 2520, 2554, 2953, 3234, 3806, 3815, 3865, 3881, 4114, 4119, 4715], 'line': [51, 283, 1990, 1999, 2081, 3807, 3816, 4115, 4120], '((10.1)Val5)': [52, 284], 'engineered': [53, 285], 'to': [54, 163, 188, 197, 286, 395, 420, 429, 1361, 1413, 1574, 2153, 2157, 2183, 2228, 2344, 2347, 2364, 2404, 2507, 2559, 2809, 2847, 2863, 2906, 2926, 2939, 2966, 3005, 3223, 3390, 3576, 3744, 4058, 4067, 4150, 4179, 4297, 4320, 4328, 4343, 4362, 4457, 4918, 4942, 4966, 5252, 5278, 5381, 5445], 'overexpress': [55, 287], 'wild-type': [56, 288, 1355, 2724, 3345], '(wt)': [57, 289, 1356], 'at': [59, 65, 291, 297, 723, 2043, 2090, 2095, 2138, 2445, 2466, 2484, 2499, 2550, 2640, 2647, 2674, 2688, 2796, 2812, 2919, 3130, 3148, 3385, 3464, 3471, 3508, 3515, 3570, 3624, 3663, 3672, 3710, 4023], '32': [60, 292, 2091, 2154, 2560, 2864, 3391, 3465, 3472, 3578, 3625, 3664], '°C': [61, 293, 2092, 2097, 2140, 2155, 2159, 2447, 2561, 2642, 2676, 2690, 2814, 2865, 3387, 3392, 3395, 3572, 3579, 3582], 'or': [62, 190, 294, 422, 1486, 2156, 2336, 2866, 3069, 3393, 3580, 3733, 3966, 3997, 4306, 4309, 4318, 4355, 4946], 'mutant': [63, 86, 103, 142, 295, 318, 335, 374, 1724, 2086, 2094, 3204, 3254, 3333, 3348, 3821, 4417, 4679, 4926], '39': [66, 298, 2096, 2158, 2867, 3394, 3509, 3516, 3581, 3673, 3711], '°C.': [67, 299, 2501, 2552, 2868, 2921, 3132], 'Cells': [68, 300, 2793, 3950, 3978], 'expressing': [69, 85, 115, 130, 141, 301, 317, 347, 362, 373, 3344, 3766, 3808, 4121, 4678], 'wt': [70, 98, 116, 131, 302, 330, 348, 363, 1711, 2089, 3188, 3243, 3270, 3329, 3525, 3767, 3809, 3876, 3886, 3974, 4011, 4122, 4412, 4433, 4851, 5154], 'showed': [72, 304], 'about': [73, 305, 1049, 3191, 3802, 3824, 3854], 'a': [74, 306, 539, 993, 1085, 1091, 1491, 1714, 1729, 2083, 2331, 2337, 2377, 2419, 2741, 2782, 2797, 2931, 2961, 3070, 3141, 3246, 3407, 3787, 3825, 3855, 4073, 4282, 4302, 4338, 4896, 5170, 5383, 5408, 5418], '10-fold': [75, 307], 'decrease': [76, 308, 1716, 3827, 5436], 'synthesis': [78, 310, 531, 2186, 3219, 3759, 4855], 'with': [83, 145, 183, 315, 377, 415, 1590, 2036, 2168, 2330, 2356, 2448, 2667, 2680, 2889, 2930, 3036, 3420, 3603, 3812, 3953, 3967, 3982, 4097, 4117, 4185, 4301, 4337, 4357, 4392, 4850, 5033, 5257], 'those': [84, 316], 'p53.': [87, 104, 117, 149, 319, 336, 349, 381, 3201, 3349, 3768, 4068, 4123, 4418, 4680, 4913], 'Levels': [88, 320, 2223, 3319, 5120], 'protein': [91, 185, 323, 417, 1858, 2229, 2950, 2957, 2964, 3236, 3276, 3339, 3401, 4305, 4441], 'mRNA': [93, 325, 3315, 3322, 3608, 3726, 3763], 'were': [94, 326, 1774, 1784, 1793, 1803, 1809, 1818, 1832, 1860, 1872, 1885, 1889, 1932, 1977, 2121, 2143, 2150, 2197, 2226, 2233, 2292, 2354, 2395, 2410, 2504, 2526, 2546, 2556, 2566, 2581, 2616, 2626, 2664, 2710, 2794, 2836, 2860, 2877, 2904, 3059, 3118, 3136, 3163, 3277, 3323, 3388, 3418, 3568, 3742, 3784, 3872, 3945, 3951, 3979, 4041, 4132, 4275], 'markedly': [95, 327, 983, 4409], 'suppressed': [96, 328], 'by': [97, 102, 126, 137, 329, 334, 358, 369, 593, 1125, 1585, 1891, 1993, 2194, 2199, 2276, 2299, 2516, 2713, 2732, 3016, 3061, 3138, 3165, 3284, 3316, 3801, 3874, 4026, 4146, 4376, 4411, 4416, 4432, 4449, 4575, 4912, 4962, 5044, 5093], 'Nuclear': [105, 337, 1824], 'run-offs': [106, 338, 1926, 3741], 'revealed': [107, 179, 339, 411], 'decreased': [108, 340, 3341, 4088], 'rates': [109, 341, 3730, 3757], 'transcription': [112, 172, 344, 404, 1584, 1592, 2575, 3011, 3732, 4158, 4166, 4961, 5158, 5262, 5385], 'cells': [114, 129, 140, 146, 226, 346, 361, 372, 378, 458, 788, 1360, 1756, 2196, 2525, 2839, 2859, 2876, 3186, 3196, 3291, 3343, 3383, 3463, 3470, 3507, 3514, 3567, 3623, 3662, 3671, 3709, 3765, 4447, 4677, 4781, 4849, 5010], 'The': [118, 150, 201, 350, 382, 433, 581, 713, 1938, 1987, 2079, 2147, 2163, 2189, 2289, 2324, 2352, 2509, 2553, 2618, 2662, 2723, 2736, 2777, 2912, 2922, 3042, 3180, 3598, 3793, 3867, 4015, 4124, 4399, 4958, 5072], 'activity': [119, 160, 351, 392, 2881, 2929, 2944, 3794, 3831, 3861, 3895, 4036, 4087, 4104, 4131, 4145], 'promoter': [123, 159, 193, 355, 391, 425, 2701, 3001, 3790, 3798, 3830, 3845, 3860, 3894, 3906, 4064, 4078, 4094, 4099, 4108, 4130, 4137, 4293], 'was': [124, 134, 161, 356, 366, 393, 1840, 1899, 1908, 1991, 2165, 2181, 2265, 2327, 2350, 2371, 2439, 2461, 2514, 2637, 2729, 2740, 2781, 2856, 2882, 2886, 2914, 2924, 2958, 3014, 3028, 3045, 3123, 3146, 3158, 3177, 3237, 3281, 3404, 3589, 3601, 3799, 4020, 4037, 4070, 4109, 4148, 4334, 4374], 'reduced': [125, 135, 357, 367, 3324, 3800], '85%': [127, 359, 3803], 'only': [136, 368, 4335], '30%': [138, 370, 3826], 'null': [147, 379, 979, 3199, 3942], 'for': [148, 186, 216, 380, 418, 448, 780, 981, 1744, 1790, 1828, 1924, 2160, 2412, 2442, 2463, 2477, 2490, 2562, 2643, 2658, 2671, 2691, 2909, 2916, 3125, 3151, 3200, 3299, 3396, 3424, 3583, 3943, 3973, 3993, 4008, 4043, 4164, 4423, 4900, 4969, 5164, 5414, 5425, 5459], 'effect': [151, 383, 4977], 'on': [154, 386, 1218, 2270, 3107, 3272, 5076], 'suppression': [156, 388, 1094, 1227, 3249, 4142, 4428, 5249], 'localized': [162, 394, 4149], 'first': [165, 397, 4152], '40': [166, 398, 4153], 'base': [167, 199, 399, 431, 477, 506], 'pairs': [168, 400], '5′': [169, 401, 4155], 'from': [170, 195, 402, 427, 534, 1775, 1785, 1794, 1804, 1810, 1820, 1833, 1846, 1862, 1873, 1886, 1901, 1910, 1933, 1979, 2373, 2381, 2784, 3003, 3023, 3047, 3053, 4295, 4326], 'start': [173, 405, 4159], 'site.': [174, 406, 4160, 5429], 'Electrophoretic': [175, 407], 'mobility': [176, 408, 3135], 'shift': [177, 409, 3057], 'assay': [178, 410, 1831, 2927], 'competed': [182, 414], 'TATA-binding': [184, 416, 489, 518, 1857], 'binding': [187, 419, 1571, 4315, 5275, 5428], 'mouseCox-2': [189, 421], 'human': [191, 423, 2997, 4291, 5404], 'extending': [194, 426, 3002], '−50': [196, 428, 3004, 4342], '+52': [198, 430, 3006, 4298, 4329], 'pairs.': [200, 432], 'results': [202, 434], 'this': [204, 436, 4976, 5415, 5443], 'study': [205, 437, 4259], 'suggest': [206, 438], 'could': [213, 445, 1741, 3220, 3727, 3839, 4691, 5161, 5435], 'be': [214, 446, 1596, 1742, 3221, 4674, 4692, 4940, 4967, 5080, 5162, 5446], 'important': [215, 447, 774, 1224, 1597, 1743, 4422, 4694, 4917, 4941, 4968, 5163], 'understanding': [217, 449, 1745, 5165], 'why': [218, 450, 1746, 4437, 4451], 'are': [222, 454, 1220, 1750, 3198, 3340, 3616, 3941, 4442], 'undetectable': [223, 455, 1752, 4443], 'normal': [225, 457, 1754, 4445], 'increased': [228, 460, 4459, 4682], 'many': [230, 462, 1760], 'tumors.': [231, 463, 1043], 'Two': [464], 'different': [465, 714, 4364], 'isoforms': [466], '(Cox)': [469], '1The': [470], 'abbreviations': [471, 500], 'used': [472, 501, 2925, 4042, 4281], 'are:': [473, 502], 'Cox,': [474, 503, 3229], 'cyclooxygenase;': [475, 504], 'bp,': [476, 505], 'pair(s);': [478, 507], 'f.p.u.,': [479, 508], 'foot': [480, 509], 'print': [481, 510], 'unit;': [482, 511], 'GST,': [483, 512], 'glutathioneS-transferase;': [484, 513], 'PGE2,': [485, 514], 'E2;': [487, 516], 'TBP,': [488, 517, 4308], 'protein;': [490, 519], 'wt,': [491, 520], 'wild-type;': [492, 521], 'SSPE,': [493, 522, 2425], 'saline-sodium': [494, 523], 'phosphate-EDTA': [495, 524], 'buffer;': [496, 525], 'a.u.': [497, 526, 3619], 'arbitrary': [498, 527], 'unit.1The': [499], 'unit.': [528], 'catalyze': [529], 'prostaglandins': [533], 'arachidonic': [535, 5089, 5122], 'acid.': [536], 'Cox-1': [537, 720, 3280], 'is': [538, 544, 584, 590, 773, 778, 784, 1115, 1123, 1223, 2088, 2945, 4162, 4408, 4421, 4464, 4842, 4964, 4978, 5036, 5250, 5377, 5417], 'constitutive': [540], 'enzyme,': [541], 'whereas': [542, 3253], 'inducible': [545], '(1Smith': [546], 'W.L.': [547], 'Garavito': [548], 'R.M.': [549, 1540], 'DeWitt': [550], 'D.L.': [551, 5056], 'J.': [552, 611, 633, 648, 650, 655, 673, 750, 823, 850, 971, 1064, 1070, 1155, 1182, 1255, 1464, 1505, 1610, 1660, 1951, 2007, 2246, 2308, 3357, 3439, 3483, 3541, 3638, 3685, 3915, 4194, 4244, 4563, 4601, 4660, 4720, 4740, 4741, 4764, 5207, 5234, 5293, 5343], 'Biol.': [553, 612, 634, 751, 1276, 2247], 'Chem.': [554, 613, 635, 752, 2248], '1996;': [555, 573, 811, 839, 1022, 1143, 1171, 1559, 1649, 1967, 2023, 2218, 2769, 2985, 3373, 3455, 3499, 3557, 3654, 3701, 3931, 4233, 4593, 5064, 5134, 5332], '271:': [556], '33157-33160Abstract': [557], 'Full': [558, 560, 617, 639, 756, 758, 869, 1025, 1027, 1201, 1320, 2252, 2254, 4620, 4831, 4833, 5021], 'Text': [559, 561, 618, 640, 757, 759, 870, 1026, 1028, 1202, 1321, 2253, 2255, 4621, 4832, 4834, 5022], 'PDF': [562, 619, 641, 760, 871, 1029, 1203, 1322, 2256, 4622, 4835, 5023], 'PubMed': [563, 576, 620, 642, 661, 683, 708, 761, 842, 872, 953, 1030, 1174, 1204, 1247, 1280, 1305, 1323, 1346, 1382, 1401, 1446, 1476, 1509, 1532, 1562, 1629, 1652, 1669, 1688, 1970, 2026, 2056, 2074, 2111, 2257, 2284, 2319, 2772, 2988, 3376, 3458, 3502, 3560, 3657, 3704, 3934, 4213, 4236, 4253, 4545, 4623, 4670, 4747, 4798, 4836, 4995, 5024, 5067, 5115, 5137, 5196, 5226, 5243, 5312, 5335, 5352], 'Scopus': [564, 577, 662, 709, 762, 843, 873, 954, 1031, 1175, 1205, 1248, 1281, 1306, 1324, 1347, 1383, 1402, 1447, 1477, 1510, 1533, 1563, 1630, 1653, 1670, 1689, 1971, 2027, 2057, 2075, 2112, 2258, 2285, 2320, 2773, 2989, 3377, 3459, 3503, 3561, 3658, 3705, 3935, 4214, 4237, 4254, 4546, 4624, 4748, 4799, 4837, 4996, 5025, 5068, 5116, 5138, 5197, 5227, 5244, 5313, 5336, 5353], '(1828)': [565], 'Google': [566, 579, 621, 643, 664, 684, 711, 764, 814, 845, 875, 894, 921, 938, 956, 976, 1033, 1112, 1146, 1177, 1207, 1250, 1283, 1308, 1326, 1349, 1385, 1404, 1449, 1479, 1512, 1535, 1551, 1565, 1632, 1655, 1672, 1691, 1973, 2029, 2059, 2077, 2114, 2221, 2260, 2287, 2322, 2775, 2991, 3379, 3461, 3505, 3563, 3660, 3707, 3937, 4216, 4239, 4256, 4486, 4513, 4530, 4548, 4568, 4596, 4626, 4649, 4671, 4732, 4750, 4774, 4801, 4839, 4889, 4998, 5027, 5070, 5118, 5140, 5199, 5229, 5246, 5315, 5338, 5355, 5373], 'Scholar,': [567, 622, 644, 665, 685, 815, 846, 876, 895, 922, 939, 957, 1147, 1178, 1251, 1284, 1309, 1327, 1386, 1450, 1513, 1536, 1552, 1633, 1656, 1673, 2060, 4217, 4240, 4487, 4514, 4531, 4549, 4597, 5230, 5316, 5339, 5356], '2Herschman': [568], 'H.R.': [569, 610], 'Biochim.': [570], 'Biophys.': [571], 'Acta.': [572], '1299:': [574], '125-140Crossref': [575], '(1159)': [578], 'Scholar).': [580, 712, 765, 977, 1113, 1350, 1405, 1480, 1566, 1692, 2078, 2115, 2222, 2261, 2288, 2323, 2776, 2992, 4257, 4569, 4840, 4890, 4999, 5028, 5071, 5119, 5247, 5374], 'gene': [583, 588, 1705, 4181], 'an': [585, 1843, 3126, 3421, 4693, 5037], 'early': [586], 'response': [587], 'rapidly': [591], 'induced': [592, 1053], 'phorbol': [594, 3890], 'esters,': [595], 'cytokines,': [596], 'growth': [597, 1230, 1423, 4628, 4810, 4859, 4908], 'factors,': [598], 'carcinogens': [600], '(3Kujubu': [601], 'D.A.': [602, 624, 819, 1151, 1947, 2003, 3353, 3435, 3479, 3537, 3634, 3681, 3911], 'Fletcher': [603], 'B.S.': [604, 1106], 'Varnum': [605], 'B.C.': [606], 'Lim': [607], 'R.W.': [608], 'Herschman': [609, 2716, 4765], '1991;': [614, 1529, 2053, 5193], '266:': [615], '12866-12872Abstract': [616], '4Jones': [623], 'Carlton': [625], 'D.P.': [626], 'McIntyre': [627, 824, 1156, 1952, 2008, 3358, 3440, 3484, 3542, 3639, 3686, 3916], 'T.M.': [628, 825, 1157, 1953, 2009, 3359, 3441, 3485, 3543, 3640, 3687, 3917], 'Zimmerman': [629, 826, 1158, 1954, 2010, 3360, 3442, 3486, 3544, 3641, 3688, 3918], 'G.A.': [630, 827, 1159, 1955, 2011, 3361, 3443, 3487, 3545, 3642, 3689, 3919], 'Prescott': [631, 830, 1162, 1958, 2014, 3364, 3446, 3490, 3548, 3645, 3692, 3922], 'S.M.': [632, 831, 1163, 1959, 2015, 3365, 3447, 3491, 3549, 3646, 3693, 3923, 4768], '1993;': [636, 1379, 1398, 1506, 1666, 2071, 2108, 4250, 5240, 5349, 5370], '268:': [637], '9049-9054Abstract': [638], '5DuBois': [645], 'R.N.': [646, 862, 1194, 4613, 4726, 4787, 4826, 5016], 'Awad': [647], 'Morrow': [649, 857, 1189, 4608, 4721], 'Roberts': [651], 'L.J.': [652, 1554], 'Bishop': [653], 'P.R.': [654], 'Clin.': [656, 4742], 'Invest.': [657], '1994;': [658, 680, 1548, 1685, 4667, 4992], '93:': [659, 840, 1172, 1650, 1968, 2024, 2770, 2986, 3374, 3456, 3500, 3558, 3655, 3702, 3932, 4234, 4829, 5065, 5333], '493-498Crossref': [660], '(377)': [663], '6Rimarachin': [666], 'J.A.': [667, 669, 886, 4478, 4654, 4656, 4883], 'Jacobson': [668, 4655], 'Szabo': [670, 4657], 'P.': [671, 930, 1062, 4522, 4658], 'Maclouf': [672, 4659], 'Creminon': [674, 4661], 'C.': [675, 743, 1066, 1068, 1556, 4662], 'Weksler': [676, 805, 1137, 2212, 4587, 4663, 5458], 'B.B.': [677, 806, 1138, 2213, 4588, 4664], 'Arterioscl.': [678, 4665], 'Thromb.': [679, 4666], '14:': [681, 4668], '1021-1031Crossref': [682, 4669], '7Kelley': [686], 'D.J.': [687, 1369], 'Mestre': [688], 'J.R.': [689, 4631], 'Subbaramaiah': [690, 2240, 4632], 'K.': [691, 796, 907, 941, 943, 1104, 1128, 2203, 2241, 4499, 4533, 4535, 4578, 4633], 'Sacks': [692, 4634], 'P.G.': [693, 4635], 'Schantz': [694, 4636], 'S.P.': [695, 1538, 4637], 'Tanabe': [696, 748, 4638], 'T.': [697, 749, 915, 1100, 1396, 1499, 1618, 1677, 2306, 4202, 4507, 4639, 4873, 4984, 5215, 5301], 'Inoue': [698, 4640], 'H.': [699, 741, 852, 897, 911, 928, 1010, 1060, 1184, 1635, 2304, 2755, 2971, 4219, 4489, 4503, 4520, 4603, 4641, 4718, 4766, 4822, 5318], 'Ramonetti': [700, 799, 1131, 2206, 4581], 'J.T.': [701, 800, 1132, 2207, 4582, 4758, 5052], 'Dannenberg': [702, 807, 1139, 2214, 2244, 4589, 4642], 'A.J.': [703, 808, 1140, 1315, 1616, 2050, 2068, 2105, 2215, 2245, 4200, 4590, 4643, 5213, 5299], 'Carcinogenesis.': [704], '1997;': [705, 866, 935, 973, 1080, 1198, 4527, 4565, 4617, 4646, 4795], '18:': [706], '795-799Crossref': [707], '(148)': [710], 'responses': [715], 'encoding': [719, 2041], 'Cox-2reflect,': [722], 'least': [724, 2648], 'part,': [726], 'differences': [727, 3224, 3721, 4128], 'regulatory': [730], 'elements': [731, 5177], '5′-flanking': [734], 'regions': [735, 4321], 'two': [738, 4363], '(8Inoue': [740], 'Yokoyama': [742], 'Hara': [744], 'S.': [745, 837, 888, 905, 909, 1072, 1169, 1236, 1290, 1300, 1341, 1527, 1546, 1624, 1647, 1683, 1965, 2021, 2314, 2767, 2983, 3371, 3453, 3497, 3555, 3652, 3699, 3929, 4208, 4231, 4480, 4497, 4501, 4756, 4785, 4793, 4818, 4820, 4990, 5062, 5110, 5191, 5221, 5307, 5330], 'Tone': [746], 'Y.': [747, 899, 1497, 1675, 4491, 4982, 5368], '1995;': [753, 891, 918, 950, 1343, 1473, 4483, 4510, 4542, 5018], '270:': [754], '24965-24971Abstract': [755], '(467)': [763], 'Numerous': [766], 'studies': [767, 1579], 'support': [768], 'idea': [770], 'carcinogenesis.': [776], 'It': [777, 1114, 4841, 4914, 4937], 'known,': [779], 'example,': [781, 4427, 5268], 'up-regulated': [785], 'transformed': [787], 'various': [791], 'forms': [792, 4927], 'cancer': [794, 1098, 4848], '(9Subbaramaiah': [795, 1127, 2202, 4577], 'Telang': [797, 1129, 2204, 4579], 'N.': [798, 821, 926, 1130, 1153, 1612, 1949, 2005, 2205, 2243, 3355, 3437, 3481, 3539, 3636, 3683, 3913, 4196, 4518, 4580, 5209, 5295, 5358, 5362], 'Araki': [801, 1133, 2208, 4583], 'R.': [802, 945, 1074, 1134, 1458, 1501, 1614, 2209, 4198, 4537, 4584, 5211, 5297], 'DeVito': [803, 1135, 2210, 4585], 'B.': [804, 1012, 1136, 1242, 1265, 1271, 2211, 4586, 4879, 5102], 'Cancer': [809, 889, 916, 933, 1078, 1107, 1141, 2216, 4481, 4508, 4525, 4591, 4644, 4727, 4769, 4884], 'Res.': [810, 890, 917, 934, 1079, 1108, 1142, 2217, 4482, 4509, 4526, 4592, 4645, 4728, 4770, 4885], '56:': [812, 1144, 2219, 4594], '4424-4429PubMed': [813, 1145, 2220, 4595], '10Kutchera': [816, 1148], 'W.': [817, 1149, 1945, 2001, 3351, 3433, 3477, 3535, 3632, 3679, 3909, 4875], 'Jones': [818, 1150, 1946, 2002, 3352, 3434, 3478, 3536, 3633, 3680, 3910], 'Matsunami': [820, 1152, 1948, 2004, 3354, 3436, 3480, 3538, 3635, 3682, 3912], 'Groden': [822, 1154, 1950, 2006, 3356, 3438, 3482, 3540, 3637, 3684, 3914], 'White': [828, 1160, 1956, 2012, 3362, 3444, 3488, 3546, 3643, 3690, 3920], 'R.L.': [829, 901, 1161, 1957, 2013, 3363, 3445, 3489, 3547, 3644, 3691, 3921, 4493], 'Proc.': [832, 1075, 1164, 1295, 1336, 1522, 1619, 1642, 1678, 1960, 2016, 2309, 2762, 2978, 3366, 3448, 3492, 3550, 3647, 3694, 3924, 4203, 4226, 4788, 4985, 5057, 5105, 5186, 5216, 5302, 5325], 'Natl.': [833, 1165, 1296, 1337, 1523, 1620, 1643, 1679, 1961, 2017, 2310, 2763, 2979, 3367, 3449, 3493, 3551, 3648, 3695, 3925, 4204, 4227, 4789, 4986, 5058, 5106, 5187, 5217, 5303, 5326], 'Acad.': [834, 1166, 1297, 1338, 1524, 1621, 1644, 1680, 1962, 2018, 2311, 2764, 2980, 3368, 3450, 3494, 3552, 3649, 3696, 3926, 4205, 4228, 4790, 4987, 5059, 5107, 5188, 5218, 5304, 5327], 'Sci.': [835, 1167, 1298, 1339, 1525, 1622, 1645, 1681, 1963, 2019, 2312, 2765, 2981, 3369, 3451, 3495, 3553, 3650, 3697, 3927, 4206, 4229, 4791, 4988, 5060, 5108, 5189, 5219, 5305, 5328], 'U.': [836, 1168, 1299, 1340, 1526, 1623, 1646, 1682, 1964, 2020, 2313, 2766, 2982, 3370, 3452, 3496, 3554, 3651, 3698, 3928, 4207, 4230, 4792, 4989, 5061, 5109, 5190, 5220, 5306, 5329], 'A.': [838, 903, 924, 1170, 1301, 1331, 1342, 1441, 1466, 1528, 1606, 1625, 1648, 1684, 1966, 2022, 2315, 2768, 2984, 3372, 3454, 3498, 3556, 3653, 3700, 3930, 4190, 4209, 4232, 4495, 4516, 4794, 4991, 5063, 5111, 5192, 5203, 5222, 5289, 5308, 5331, 5360], '4816-4820Crossref': [841, 1173, 1969, 2025, 3375, 3457, 3501, 3559, 3656, 3703, 3933], '(444)': [844, 1176, 1972, 2028, 3378, 3460, 3504, 3562, 3659, 3706, 3936], '11Sheng': [847, 1179, 4598], 'G.G.': [848, 1180, 4599], 'Shao': [849, 1181, 4600, 4719], 'Sheng': [851, 1183, 4602], 'Hooton': [853, 1185, 4604], 'E.B.': [854, 1186, 4605], 'Isakson': [855, 1187, 4606], 'P.C.': [856, 1188, 4607], 'J.D.': [858, 1190, 4609, 4722], 'Coffey': [859, 1191, 4610], 'R.J.': [860, 1192, 4611], 'DuBois': [861, 1193, 4612, 4725, 4786, 4825, 5015], 'Beauchamp': [863, 1195, 4614, 4723], 'R.D.': [864, 1196, 4615, 4724], 'Gastroenterology.': [865, 1197, 4616], '113:': [867, 1199, 4618], '1883-1891Abstract': [868, 1200, 4619], '(180)': [874, 1206, 4625], '12Kargman': [877], 'S.L.': [878, 1008, 4470], "O'Neill": [879, 4471], 'G.P.': [880, 1608, 4192, 4472, 5205, 5291], 'Vickers': [881, 4473], 'P.J.': [882, 4474, 5100], 'Evans': [883, 1017, 4475], 'J.F.': [884, 1018, 4476], 'Mancini': [885, 4477], 'Jothy': [887, 4479], '55:': [892, 919, 4484, 4511], '2556-2559PubMed': [893, 4485], '13Sano': [896, 4488], 'Kawahito': [898, 4490], 'Wilder': [900, 4492], 'Hashiramoto': [902, 4494], 'Mukai': [904, 4496], 'Asai': [906, 4498], 'Kimura': [908, 4500], 'Kato': [910, 4502], 'Kondo': [912, 4504], 'M.': [913, 932, 1004, 1263, 1267, 1294, 1431, 1503, 1519, 1521, 4505, 4524, 4752, 4754, 4783, 4816, 4824, 4867, 4871, 5014, 5183, 5185, 5366], 'Hla': [914, 4506], '3785-3789PubMed': [920, 4512], '14Ristimaki': [923, 4515], 'Honkanen': [925, 4517], 'Jankala': [927, 4519], 'Sipponen': [929, 4521], 'Harkonen': [931, 4523], '57:': [936, 1318, 4528, 4647], '1276-1280PubMed': [937, 4529], '15Muller-Decker': [940, 4532], 'Scholz': [942, 4534], 'Marks': [944, 4536], 'Furstenberger': [946, 4538], 'G.': [947, 1261, 4539], 'Mol.': [948, 1274, 4540], 'Carcinogen.': [949, 4541], '12:': [951, 1507, 4543], '31-41Crossref': [952, 4544], '(137)': [955, 4547], '16Parett': [958, 4550], 'M.L.': [959, 1329, 1375, 4551, 5054], 'Harris': [960, 4552], 'R.E.': [961, 4553], 'Joarder': [962, 4554], 'F.S.': [963, 4555], 'Ross': [964, 4556], 'M.S.': [965, 4557], 'Clausen': [966, 4558], 'K.P.': [967, 4559], 'Robertson': [968, 4560], 'F.M.': [969, 4561], 'Int.': [970, 4562], 'Oncol.': [972, 4564], '10:': [974, 1278, 1560, 4566], '503-507PubMed': [975, 4567], 'A': [978, 1923, 2341, 2684, 2993, 3170], 'mutation': [980, 4688], 'reduces': [984], 'number': [986, 1492], 'size': [988], 'intestinal': [990, 3032, 5008], 'tumors': [991], 'murine': [994, 1939, 2450, 3788, 4076, 4289, 5402], 'model': [995], 'familial': [997], 'adenomatous': [998], 'polyposis,i.e.': [999], 'APCΔ716': [1000], 'knockout': [1001, 1046], 'mice': [1002, 1047, 1058], '(17Oshima': [1003], 'Dinchuk': [1005], 'J.E.': [1006], 'Kargman': [1007], 'Oshima': [1009], 'Hancock': [1011], 'Kwong': [1013], 'E.': [1014, 1604, 1637, 2757, 2973, 4188, 4221, 5201, 5287, 5320], 'Trazaskos': [1015], 'J.M.': [1016, 1662, 4246, 5236, 5345], 'Taketo': [1019], 'M.M.': [1020], 'Cell.': [1021, 1275, 1316, 4827, 5017], '87:': [1023], '803-809Abstract': [1024], '(2268)': [1032], 'Scholar).Cox-2': [1034], 'deficiency': [1035], 'also': [1036, 1116, 3835, 3888, 3980, 4939, 5079], 'protects': [1037], 'against': [1038], 'formation': [1040, 1427, 4369, 4389, 5395], 'extraintestinal': [1042], 'Thus,': [1044, 4706], 'developed': [1048], '75%': [1050], 'fewer': [1051], 'chemically': [1052], 'skin': [1054], 'papillomas': [1055], 'than': [1056, 3195], 'control': [1057], '(18Tiano': [1059], 'Chulada': [1061], 'Spalding': [1063], 'Lee': [1065, 4880], 'Loftin': [1067], 'Mahler': [1069], 'Morham': [1071], 'Langenbach': [1073], 'Am.': [1076], 'Assoc.': [1077], '38:': [1081], '1727Google': [1082], 'Scholar),': [1083, 1208, 4627, 4650, 4733, 4775, 4802, 5141], 'selective': [1086, 1422], 'inhibitor': [1087], 'caused': [1090, 3245, 3823, 3853], 'nearly': [1092, 3247], 'complete': [1093, 3248], 'azoxymethane-induced': [1096], 'colon': [1097], '(19Kawamori': [1099], 'Rao': [1101], 'C.V.': [1102], 'Seibert': [1103], 'Reddy': [1105], '1998;': [1109, 2249, 4729, 4771, 4828, 4886, 5112], '58:': [1110, 4730, 4772, 4887], '409-412PubMed': [1111], 'known': [1117, 4844], 'enhanced': [1124, 4675], 'oncogenes': [1126, 4576], 'effects': [1211, 1701, 3268, 3869, 5073], 'genes,': [1215], 'e.g.': [1216], 'p53,': [1217, 2035, 3944], 'unstudied.': [1221], 'cellular': [1229, 2369, 2391, 3587], 'transformation': [1232], '(20Baker': [1233], 'S.J.': [1234, 1269], 'Markowitz': [1235], 'Fearon': [1237], 'E.R.': [1238], 'Willson': [1239], 'J.K.': [1240], 'Vogelstein': [1241, 1270, 5101], 'Science.': [1243, 5133], '1990;': [1244, 1277], '249:': [1245], '912-915Crossref': [1246], '(1600)': [1249, 1325], '21Diller': [1252], 'L.': [1253, 4760], 'Kassel': [1254], 'Nelson': [1256], 'C.E.': [1257], 'Gryka': [1258], 'M.A.': [1259, 1544], 'Litwak': [1260], 'Gebhardt': [1262], 'Bressac': [1264], 'Ozturk': [1266], 'Baker': [1268], 'Friend': [1272], 'S.H.': [1273], '5772-5781Crossref': [1279], '(691)': [1282], '22Eliyahu': [1285], 'D.': [1286, 1288, 1462, 1468, 1515, 1641, 2048, 2066, 2103, 2761, 2977, 4225, 5179, 5324], 'Michalovitz': [1287], 'Eliyahu': [1289], 'Pinhasi-Kimhi': [1291], 'O.': [1292], 'Oren': [1293, 1502, 1520, 5184, 5365], '1989;': [1302, 1317], '86:': [1303], '8763-8767Crossref': [1304], '(561)': [1307], '23Finlay': [1310], 'C.A.': [1311, 1367, 1437], 'Hinds': [1312], 'P.W.': [1313, 4762], 'Levine': [1314, 1615, 1982, 2049, 2067, 2104, 4199, 5212, 5298], '1083-1093Abstract': [1319], '24Agarwal': [1328], 'Agarwal': [1330], 'Taylor': [1332], 'W.R.': [1333], 'Stark': [1334], 'G.R.': [1335], '92:': [1344], '8493-8497Crossref': [1345], '(789)': [1348], 'addition,': [1352], 'induction': [1353, 3842, 3892, 3903, 4572], 'can': [1358, 1411, 1483, 4435, 5143], 'cause': [1359, 1728], 'undergo': [1362], 'apoptosis': [1363, 5012, 5043, 5077], '(25Clarke': [1364], 'A.R.': [1365], 'Purdie': [1366], 'Harrison': [1368], 'Morris': [1370], 'R.G.': [1371], 'Bird': [1372], 'C.C.': [1373], 'Hooper': [1374], 'Wyllie': [1376], 'A.H.': [1377], 'Nature.': [1378, 1397, 1442, 1665, 2280, 4249, 5239, 5348], '362:': [1380, 1399], '849-852Crossref': [1381], '(2285)': [1384], '26Lowe': [1387], 'S.W.': [1388, 1392], 'Schmitt': [1389], 'E.M.': [1390], 'Smith': [1391], 'Osborne': [1393], 'B.A.': [1394, 5048], 'Jacks': [1395], '847-852Crossref': [1400], '(2753)': [1403], 'By': [1406, 3202], 'contrast,': [1407, 1723, 3203, 3820, 4450], 'inactivation': [1408, 4945], 'lead': [1412], 'deregulation': [1414], 'cycle': [1418], 'DNA': [1420, 1852, 2835, 4019, 4339], 'replication,': [1421], 'advantage,': [1424], '(27Donehower': [1428], 'L.A.': [1429, 1452, 1454, 1664, 4248, 5238, 5347], 'Harvey': [1430, 2715], 'Slagle': [1432], 'B.L.': [1433], 'McArthur': [1434], 'M.J.': [1435], 'Montgomery': [1436], 'Butel': [1438], 'J.S.': [1439, 4738], 'Bradley': [1440, 1465], '1992;': [1443, 1626, 4210, 5223, 5309], '356:': [1444], '215-221Crossref': [1445], '(3988)': [1448], '28Donehower': [1451], 'Godley': [1453], 'Aldaz': [1455], 'C.M.': [1456], 'Pyle': [1457], 'Shi': [1459], 'Y.-P.': [1460], 'Pinkel': [1461], 'Gray': [1463], 'Medina': [1467], 'Varmus': [1469], 'H.E.': [1470], 'Genes': [1471, 1557, 2051, 2069, 2106], 'Dev.': [1472, 1558, 2052, 2070, 2107], '9:': [1474, 1549], '882-895Crossref': [1475], '(246)': [1478], 'Significantly,': [1481], 'either': [1484, 3577], 'increase': [1485, 3857, 4776], 'suppress': [1487], 'target': [1494], '(29Barak': [1496], 'Juven': [1498], 'Haffner': [1500], 'EMBO': [1504], '461-468Crossref': [1508], '(1165)': [1511], '30Ginsberg': [1514], 'Mechtor': [1516, 5180], 'F.': [1517, 2239, 5181], 'Yaniv': [1518, 5182], '88:': [1530, 5194], '7605-7609Crossref': [1531, 5195], '(307)': [1534, 5198], '31Deb': [1537], 'Munoz': [1539], 'Brown': [1541], 'D.R.': [1542], 'Subler': [1543], 'Deb': [1545], 'Oncogene.': [1547, 5369], '1341-1349PubMed': [1550], '32Ko': [1553], 'Prives': [1555], '1054-1072Crossref': [1561], '(2279)': [1564], 'Gene': [1567], 'activation': [1568], 'usually': [1569], 'involves': [1570], 'specific': [1575, 3423], 'consensus': [1576], 'sequences.': [1577], 'Recent': [1578], 'indicate': [1580], 'repression': [1582, 4959], 'may': [1587, 1595, 4455, 4673], 'involve': [1588], 'interaction': [1589, 5256], 'basal': [1591, 5261], 'machinery': [1593], 'mediating': [1599], 'programmed': [1600], 'death': [1602], '(33Seto': [1603, 4187, 5286], 'Usheva': [1605, 4189, 5202, 5288], 'Zambetti': [1607, 4191, 5204, 5290], 'Momand': [1609, 4193, 5206, 5292], 'Horikoshi': [1611, 4195, 5208, 5294], 'Weinmann': [1613, 4197, 5210, 5296], 'Shenk': [1617, 1676, 4201, 4983, 5214, 5300], '89:': [1627, 4211, 5224, 5310], '12028-12032Crossref': [1628, 4212, 5225, 5311], '(463)': [1631, 4215, 5228, 5314], '34Werner': [1634, 4218, 5317], 'Karnieli': [1636, 2756, 2972, 4220, 5319], 'Rauscher': [1638, 2758, 2974, 4222, 5321], 'F.J.': [1639, 2759, 2975, 4223, 5322], 'LeRoith': [1640, 2747, 2760, 2976, 4224, 5323], '8318-8323Crossref': [1651, 2771, 2987, 4235, 5334], '(331)': [1654, 2774, 2990, 4238, 5337], '35Mack': [1657, 4241, 5231, 5340], 'D.H.': [1658, 4242, 5232, 5341], 'Vartikar': [1659, 4243, 5233, 5342], 'Pipas': [1661, 4245, 5235, 5344], 'Laimins': [1663, 4247, 5237, 5346], '363:': [1667, 4251, 5241, 5350], '281-283Crossref': [1668, 4252, 5242, 5351], '(301)': [1671, 4255, 5245, 5354], '36Shen': [1674], '91:': [1686, 4993], '8940-8944Crossref': [1687, 4994], '(142)': [1690, 4997], 'investigated': [1699, 3836], 'onCox-2': [1704], 'expression.': [1706], 'Our': [1707], 'data': [1708, 3181, 4401, 4894], 'show': [1709, 3184, 4402], 'causes': [1713], 'marked': [1715], 'Cox-2.': [1721, 1735, 3262, 3425, 4957], 'did': [1726, 3206, 3256, 4312, 4385], 'significant': [1730], 'reduction': [1731], 'Interactions': [1736, 5430], 'essentially': [1751], 'epithelial': [1755, 4446, 5009], 'elevated': [1758], 'cancers.': [1761], "Dulbecco's": [1762, 2129, 2535, 2816], 'modified': [1763, 2130, 2536, 2817], "Eagle's": [1764, 2131, 2537, 2818], 'medium,': [1765], 'fetal': [1766, 2135, 2541, 2822], 'bovine': [1767, 2136, 2542, 2823, 3099], 'serum,': [1768, 2824], 'calcium': [1770, 2842], 'phosphate': [1771, 2843], 'transfection': [1772, 1995, 4045], 'kits': [1773, 1802, 1854], 'Life': [1776], 'Technologies,': [1777], 'Inc.': [1778, 1848, 1877, 1894, 1904, 1914, 1935, 2383, 3055], 'Sodium': [1779], 'arachidonate': [1780], 'poly(deoxyinosinic-deoxycytidylic': [1782, 3105], 'acid)': [1783, 3106], 'Sigma.': [1786], 'Enzyme': [1787], 'immunoassay': [1788, 2201], 'reagents': [1789, 1884], 'PGE2': [1791, 2192, 3194], 'assays': [1792, 3058, 4274], 'Cayman': [1795], 'Co.': [1796], '(Ann': [1797], 'Arbor,': [1798], 'MI).': [1799], 'Random': [1800], 'priming': [1801], 'Boehringer': [1805], 'Mannheim.': [1806], 'Nitrocellulose': [1807], 'membranes': [1808, 2409, 2503, 2663], 'Schleicher': [1811], '&': [1812], 'Schuell.': [1813], '[32P]ATP,': [1814], '[32P]CTP,': [1815], '[32P]UTP': [1817], 'obtained': [1819, 1978], 'DuPont': [1821], 'New': [1822, 1911, 2790], 'England': [1823, 1912], '(Boston,': [1825], 'MA).': [1826, 1916], 'Reagents': [1827], 'luciferase': [1830, 2880, 2928, 3791, 3958, 4035], 'Analytical': [1834], 'Luminescence': [1835, 2899, 2936], '(San': [1836], 'Diego,': [1837, 2902], 'CA).': [1838, 1850, 1880, 2722], 'RNA': [1839, 2370, 2378, 2392, 2614, 2656, 3588], 'prepared': [1841, 2234, 2959], 'using': [1842, 2376, 2646, 2840, 3030, 3038, 3050, 3786, 4027, 4072], 'isolation': [1844, 1853, 2379], 'kit': [1845, 2380], 'QIAGEN': [1847, 2382, 3054], '(Chatsworth,': [1849], 'Plasmid': [1851], 'recombinant': [1856], '(TBP)': [1859], 'purchased': [1861, 1900, 1909], 'Promega': [1863], '(Madison,': [1864], 'WI).': [1865], 'Goat': [1866], 'polyclonal': [1867, 2333, 2338], 'anti-Cox-2': [1868, 2334], 'anti-Cox-1': [1870, 2339], 'antisera': [1871], 'Santa': [1874], 'Cruz': [1875], 'Biotechnology,': [1876], '(Santa': [1878], 'Cruz,': [1879], 'Western': [1881, 2359, 3230, 3285], 'blotting': [1882, 3231, 3286], 'detection': [1883, 2361], 'Amersham.': [1887], 'Oligonucleotides': [1888], 'synthesized': [1890, 3190], 'Genosys': [1892], 'Biotechnologies': [1893], '(The': [1895], 'Woodlands,': [1896], 'TX).': [1897, 1937], 'GST-agarose': [1898], 'Pharmacia': [1902], 'Biotech': [1903], 'T4': [1905, 3039], 'polynucleotide': [1906, 3040], 'kinase': [1907], 'Biolabs,': [1913], '(Beverly,': [1915], 'Proteinase': [1917], 'K,': [1918], 'RNase-free': [1919], 'DNase,': [1920], 'RNase': [1922, 2683], 'nuclear': [1925, 3740], '18': [1928, 2161, 2453, 2563, 2622, 3397, 3584, 3610], 'S': [1929, 2454, 2623, 3611], 'rRNA': [1930, 2455, 2624], 'cDNA': [1931, 2698], 'Ambion': [1934], '(Austin,': [1936], 'fibroblast-derived': [1941], 'lines': [1943, 2120, 2149, 2555], '(10Kutchera': [1944, 2000, 3350, 3432, 3476, 3534, 3631, 3678, 3908], 'Scholar)1': [1974, 3380, 3462, 3506, 3564, 3661, 3708, 3938], '(10.1)Val5': [1976, 1988, 2080, 2118, 3382, 3469, 3513, 3566, 3622, 3670], 'Dr.': [1980, 2714, 2733, 2745, 2785], 'Arnold': [1981, 2734], '(Princeton': [1983], 'University,': [1984], 'Princeton,': [1985], 'NJ).': [1986], 'generated': [1992], 'stable': [1994], 'parental': [1997], 'Scholar)1,': [2030], 'which': [2031, 3940, 4812, 5035, 5142], 'contains': [2032, 2082], 'no': [2033, 5378], 'endogenous': [2034], 'temperature-sensitive': [2038, 2084], 'allele': [2040], 'valine': [2042], 'amino': [2044], 'acid': [2045, 5090], '135': [2046], '(37Harvey': [2047], '5:': [2054], '2375-2385Crossref': [2055], '(410)': [2058], '38Wu': [2061], 'X.': [2062, 2099], 'Bayle': [2063, 2100], 'J.H.': [2064, 2101], 'Olson': [2065, 2102], '7:': [2072, 2109], '1126-1132Crossref': [2073, 2110], '(1614)': [2076, 2113], '(38Wu': [2098], '(10)1': [2116], 'plated': [2122, 2527], '6-well': [2124, 2805], 'plates': [2125], 'grown': [2127, 2533, 2808, 3384, 3569, 3946], 'medium': [2132, 2164, 2170, 2180, 2538, 2819, 2855], 'containing': [2133, 2171, 2421, 2539, 2599, 2820, 3187], '10%': [2134, 2271, 2540, 2821, 3408], 'serum': [2137, 2543, 3100], '37': [2139, 2551, 2689, 2813, 3386, 3571], 'until': [2141, 2544], 'they': [2142, 2545], 'approximately': [2144, 2547], '40%': [2145], 'confluent.': [2146], 'then': [2151, 2166, 2328, 2416, 2505, 2557, 2678, 2861], 'shifted': [2152, 2558, 2862, 3389, 3575], 'h.': [2162, 2564, 3153, 3398, 3585], 'replaced': [2167], 'fresh': [2169], '10': [2172, 2387, 2681, 3128, 3594], 'μm': [2173], 'sodium': [2174], 'arachidonate.': [2175], '30': [2176, 2610, 2692], 'min': [2177, 2465, 2479, 2492, 2918, 3129], 'later,': [2178, 4034], 'collected': [2182], 'measure': [2184], 'PGE2.': [2188, 3211], 'released': [2193], 'measured': [2198], 'enzyme': [2200], 'PGE2production': [2225], 'normalized': [2227], 'concentrations.': [2230], 'Cell': [2231], 'lysates': [2232], 'as': [2235, 2274, 2297, 2960, 4089, 4171, 5091, 5265], 'described': [2236, 2275, 2968], 'previously': [2237, 2969], '(39Zhang': [2238], 'Altorki': [2242], '273:': [2250], '2424-2428Abstract': [2251], '(196)': [2259], 'SDS-polyacrylamide': [2262, 3409], 'gel': [2263, 3144, 3157, 4272], 'electrophoresis': [2264, 3139], 'performed': [2266, 3060, 3743, 3785], 'under': [2267, 3947], 'reducing': [2268], 'conditions': [2269], 'polyacrylamide': [2272, 3143], 'gels': [2273, 2401], 'Laemmli': [2277], '(40Laemmli': [2278], 'U.K.': [2279], '1970;': [2281], '227:': [2282], '680-685Crossref': [2283], '(205523)': [2286], 'resolved': [2290], 'proteins': [2291, 3074], 'transferred': [2293, 2403, 3414], 'onto': [2294, 2628, 3406, 3415], 'nitrocellulose': [2295, 2325, 2629], 'sheets': [2296], 'detailed': [2298], 'Towbin': [2300], 'et': [2301, 5095], 'al.': [2302, 5096], '(41Towbin': [2303], 'Staehelin': [2305], 'Gordon': [2307], '1979;': [2316], '76:': [2317], '4350-4354Crossref': [2318], '(44643)': [2321], 'membrane': [2326, 2460], 'incubated': [2329, 2584, 3124], 'goat': [2332], 'antiserum': [2335], 'antiserum.': [2340], 'secondary': [2342], 'antibody': [2343, 3422], 'IgG': [2345], 'conjugated': [2346], 'horseradish': [2348], 'peroxidase': [2349], 'used.': [2351], 'blots': [2353], 'probed': [2355, 3419], 'ECL': [2358], 'blot': [2360, 3600], 'system': [2362], 'according': [2363, 2846, 2938, 2965], "manufacturer's": [2366, 2849, 2941], 'instructions.': [2367, 2850, 2942], 'Total': [2368, 3586], 'isolated': [2372, 2567], 'monolayers': [2375], 'For': [2384, 2518, 2573, 2828, 4426, 5267], 'Northern': [2385, 3317, 3599], 'blots,': [2386], 'μg': [2388, 2832, 3595, 3955, 3969, 3984, 3989, 3999, 4004, 4025], 'total': [2390, 4016], 'per': [2393, 2947], 'lane': [2394, 3467, 3474, 3511, 3592, 3629, 3668], 'electrophoresed': [2396], 'formaldehyde-containing': [2398], '1.2%': [2399], 'agarose': [2400, 3024], 'nylon-supported': [2405], 'membranes.': [2406], 'After': [2407, 2457, 2609, 2851, 3021, 3109, 3154], 'baking,': [2408], 'prehybridized': [2411, 2631], '8': [2413], 'h': [2414, 2444, 2645, 2673, 4033], 'hybridized': [2417, 3602], 'solution': [2420, 2483], '50%': [2422, 2548], 'formamide,': [2423], '5×': [2424, 2426], "Denhardt's": [2427], 'solution,': [2428], '0.1%': [2429, 2473, 2497], 'SDS,': [2430, 2474], '100': [2432, 2600, 2892, 3092, 3112], 'μg/ml': [2433], 'single-stranded': [2434], 'salmon': [2435], 'sperm': [2436], 'DNA.': [2437, 4030], 'Hybridization': [2438, 2636], 'carried': [2440, 2638, 3238], 'out': [2441, 2639], '16': [2443, 2852], '42': [2446, 2641], 'radiolabeled': [2449], 'probes.': [2456], 'hybridization,': [2458], 'washed': [2462, 2475, 2488, 2665, 2887], '20': [2464, 2478, 2491, 3079], 'room': [2467], 'temperature': [2468], '2×': [2470, 2668, 2686], 'SSPE': [2471, 2495], 'twice': [2476, 2489, 2666, 2888], '55': [2485, 2500, 2675], '°C,': [2486, 3626, 3665, 3674, 3712], '0.1×': [2494], 'SDS': [2498], 'Washed': [2502], 'subjected': [2506], 'autoradiography.': [2508], 'density': [2510, 2798], 'bands': [2513], 'quantified': [2515], 'densitometry.': [2517], 'each': [2519, 2659, 2829, 2907, 4044], 'line,': [2521], '2.5': [2522], '×': [2523, 2579, 2650, 2801], '105': [2524, 2651], 'four': [2529, 4032], 'T150': [2530], 'dishes': [2531, 2806], 'confluent': [2549], 'Nuclei': [2565], 'stored': [2569], 'liquid': [2571], 'nitrogen.': [2572], 'assay,': [2576], 'nuclei': [2577], '(1.0': [2578], '107)': [2580], 'thawed': [2582], 'reaction': [2586, 3019, 3122], 'buffer': [2587, 2670, 2897], '(10': [2588], 'mm': [2589, 2606, 3080, 3085], 'Tris,': [2590], 'pH': [2591], '8,': [2592], '5': [2593, 2649, 2800], 'mmMgCl2,': [2594], '0.3': [2596], 'm': [2597, 3095], 'KCl)': [2598], 'μCi': [2601], '[α-32P]UTP': [2603], '1': [2605, 2672, 2917, 3097], 'unlabeled': [2607], 'nucleotides.': [2608], 'min,': [2611, 2693, 3111], 'labeled': [2612, 2654, 3043, 3116, 4285, 4359], 'nascent': [2613, 2655, 3761], 'transcripts': [2615, 2657], 'isolated.': [2617, 3590], '(TIS10)': [2620], 'cDNAs': [2625], 'immobilized': [2627], 'overnight': [2632], 'hybridization': [2634], 'buffer.': [2635], '24': [2644], 'cpm': [2652], 'treatment': [2660, 2874], 'group.': [2661], 'SSC': [2669, 2687], 'treated': [2679], 'mg/ml': [2682, 3098, 3104], 'dried,': [2694], 'autoradiographed.': [2696, 3159], 'deletion': [2702, 4079], 'constructs': [2703, 4100], '(TIS10L,': [2704], 'TIS-300,': [2705], 'TIS-180,': [2706], 'TIS-80,': [2707], 'TIS-40)': [2709], 'generously': [2711], 'provided': [2712, 2731], '(University': [2717], 'California,': [2719], 'Los': [2720], 'Angeles,': [2721], '(pC53-SN3)': [2726], 'vector': [2728, 2780, 3972, 3992, 4029], 'kindly': [2730], 'Levine.': [2735], 'plasmid': [2737, 2834], 'construct': [2738, 3959], 'GST.p53': [2739, 3066, 4303, 4317, 4356], 'generous': [2742], 'gift': [2743, 2783], 'Derek': [2746], '(National': [2748], 'Institutes': [2749], 'Health,': [2751], 'Bethesda,': [2752], 'MD)': [2753], '(34Werner': [2754, 2970], 'v-src': [2778, 3852, 3871, 3994, 4009], 'David': [2786, 5454], 'Foster': [2787], '(Hunter': [2788], 'College,': [2789], 'York,': [2791], 'NY).': [2792], 'seeded': [2795], '104': [2802], 'cells/well': [2803], '30–40%': [2810], 'confluence': [2811], 'unless': [2825], 'stated': [2826], 'otherwise.': [2827], 'well,': [2830], '2': [2831, 3152, 4024], 'transfected': [2837, 3952], 'into': [2838], 'precipitation': [2844], 'method': [2845], 'h,': [2853], 'changed,': [2857], 'At': [2869], 'end': [2871], 'period,': [2875], 'harvested,': [2878], 'measured.': [2883, 4038], 'Each': [2884, 3591], 'well': [2885, 2908], 'phosphate-buffered': [2890], 'saline.': [2891], 'μl': [2893, 3077], '1×': [2895], 'lysis': [2896], '(Analytical': [2898, 2935], 'Laboratories,': [2900], 'San': [2901], 'CA)': [2903], 'added': [2905], '15': [2910, 3110], 'min.': [2911], 'lysate': [2913, 3235, 3400], 'centrifuged': [2915], '4': [2920], 'supernatant': [2923], 'Monolight': [2932], '2010': [2933], 'Luminometer': [2934], 'Laboratories)': [2937], 'Luciferase': [2943], 'expressed': [2946, 3617], 'microgram': [2948], 'extract.': [2954], 'Purified': [2955], 'GST': [2962, 4394], 'fusion': [2963, 4304], 'methods': [2967], 'fragment': [2994, 3027, 3117, 4340], 'COX-2or': [2998], 'encompassing': [3007], 'vivo': [3010], 'initiation': [3012, 5386], 'site': [3013], 'made': [3015, 3164], 'polymerase': [3017], 'chain': [3018], 'amplification.': [3020], 'purification': [3022, 3051], 'gels,': [3025], 'dephosphorylated': [3029], 'calf': [3031], 'phosphatase': [3033], 'end-labeled': [3035], '[γ-32P]ATP': [3037], 'kinase.': [3041], 'probe': [3044, 4360], 'separated': [3046], 'unincorporated': [3048], 'nucleotides': [3049], 'columns': [3052], 'Gel': [3056], 'preincubating': [3062], 'TBP': [3063, 4161, 4186, 4265, 4319, 4354, 5277, 5376, 5399, 5424, 5432], '(1': [3064], 'f.p.u./reaction),': [3065], '(100': [3067], 'ng),': [3068], 'combination': [3071], 'both': [3073], '9': [3076], 'Hepes': [3081], '(pH': [3082], '7.5),': [3083], '70': [3084], 'KCL,': [3086], '12%': [3087], 'glycerol,': [3088], '0.05%': [3089], 'Nonidet': [3090], 'P-40,': [3091], 'μmZnSO4,': [3093], '0.05': [3094, 3176], 'dithiothreitol,': [3096], 'albumin,': [3101], '0.1': [3103], 'ice.': [3108], 'pg': [3113], 'added,': [3119], 'additional': [3127], '25': [3131], 'Changes': [3133], 'assessed': [3137], 'through': [3140, 5254, 5283], '5%': [3142], 'run': [3147], '250': [3149], 'V': [3150], 'fixation,': [3155], 'Comparisons': [3160], 'groups': [3162, 3173], "Student's": [3167], 't': [3168], 'test.': [3169], 'difference': [3171], 'ofp': [3174], '<': [3175], 'considered': [3178], 'significant.': [3179], 'Fig.1': [3183], '90%': [3192], 'less': [3193], 'inhibit': [3208, 3840, 4180, 4734, 5042], 'To': [3212, 3293, 3769, 4258], 'evaluate': [3213], 'whether': [3214, 3837, 4944], 'inhibition': [3216], 'related': [3222], 'out.': [3239], 'Fig.2': [3240], 'shows': [3241], 'expression,': [3252], 'affect': [3258], 'other': [3264, 4949, 5002], 'experiments,': [3265, 3885, 4279], 'suppressive': [3267], 'amounts': [3273, 4381, 4931], 'COX-2': [3275], 'more': [3278], 'modest.': [3279], 'detectable': [3283], 'tested.': [3292], 'further': [3294, 3770], 'elucidate': [3295], 'mechanism': [3297, 4974], 'responsible': [3298], 'changes': [3301, 3734, 4135], 'amount': [3304, 4017], 'protein,': [3307, 5039], 'determined': [3309], 'steady-state': [3311, 3529], 'blotting.': [3318], 'presence': [3327], '(Fig.3).Figure': [3335], '2Levels': [3336], 'Cellular': [3399], '(25': [3402], 'μg/lane)': [3403], 'loaded': [3405], 'gel,': [3410], 'electrophoresed,': [3411], 'subsequently': [3413], 'nitrocellulose.': [3416], 'Immunoblots': [3417], 'Lane': [3426, 3620], '1,': [3427, 3621], 'ovine': [3428], 'standard;lane': [3430], '2,': [3431, 3630], '°C;': [3466, 3473, 3510], '3,': [3468, 3669], '4,': [3475, 3677, 3753], '5,': [3512], '°C.View': [3517], 'Large': [3518, 3715, 4050], 'Image': [3519, 3716, 4051], 'Figure': [3520, 3717, 4052], 'ViewerDownload': [3521, 3718, 4053], '(PPT)Figure': [3522], '3Expression': [3523], 'decreases': [3527, 4853], 'level': [3530], 'mRNA.': [3533], 'before': [3573], 'being': [3574], 'contained': [3593], 'RNA.': [3597], 'probes': [3604], 'recognized': [3606], 'rRNA.': [3612], 'Results': [3613], 'densitometry': [3615], '81': [3627], 'a.u.;': [3628, 3667], '206': [3666], '218': [3675], 'a.u.;lane': [3676], '216': [3713], 'a.u.View': [3714], '(PPT)': [3719, 4054], 'Because': [3720, 5029], 'reflect': [3728], 'altered': [3729], 'stability': [3737], 'mRNA,': [3739], 'distinguish': [3745], 'these': [3747, 4127, 4278], 'possibilities.': [3748], 'As': [3749, 3847, 4081], 'shown': [3750, 3848, 4082], 'Fig.': [3752, 4084], 'found': [3755], 'lower': [3756], 'investigate': [3771], 'importance': [3773], 'modulating': [3777], 'Cox-2,': [3781], 'transient': [3782], 'transfections': [3783], 'construct.': [3792], 'p53-null': [3814, 3864, 4113], '(Fig.': [3817, 3832, 4350], '5).': [3818, 3833], 'We': [3834, 4055, 4311, 4384, 5451], 'v-src-mediated': [3841, 3902], 'activity.': [3846, 3907], 'Fig.6,': [3850], 'overexpressing': [3851, 3875], '6-fold': [3856], 'line.': [3866], 'stimulatory': [3868], 'blocked': [3873, 3889], 'system.': [3882, 5410], 'separate': [3884], 'ester-mediated': [3891], 'ofCox-2': [3893], '(data': [3896, 4330, 4396], 'shown).Figure': [3898], '6Wild-type': [3899], 'suppresses': [3901, 5169], 'cells,': [3939], 'serum-free': [3948], 'conditions.': [3949], '1.0': [3954, 3983, 3998], 'TIS10L': [3960, 3986, 4001], '(963': [3961], 'bp)': [3962], 'alone': [3963, 4395], '(−p53,': [3964, 3995], '■)': [3965], '0.5': [3968, 3988, 4003], '(+p53,': [3976, 4013], '■).': [3977], 'co-transfected': [3981], 'plus': [3987, 4002], '▪)': [3996], 'vectors': [4007], '▪).': [4014], 'kept': [4021], 'constant': [4022], 'empty': [4028], 'Twenty': [4031], 'Six': [4039], 'wells': [4040], 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'together': [4300], 'purified': [4307, 4393], 'both.': [4310], 'observe': [4314, 4387], 'shown).': [4332, 4398], 'Binding': [4333], 'observed': [4336, 4465], '(from': [4341], '+52)': [4344], 'included': [4346], 'TATA': [4348, 5176, 5427], 'box': [4349], '8).': [4351], 'Incubation': [4352], 'led': [4361], 'retarded': [4365], 'bands.': [4366], 'Moreover,': [4367, 4681], 'TBP-DNA': [4372], 'complexes': [4373, 4391, 5397], 'inhibited': [4375, 5273, 5393], 'addition': [4378], 'increasing': [4380], 'GST.p53.': [4383], 'repressed': [4410], 'observation': [4420], 'several': [4424, 5279], 'reasons.': [4425], 'explain': [4436], 'and,': [4448], 'mutations': [4452], 'contribute': [4456], 'malignant': [4467, 4780, 4935], 'tissues': [4468], '(12Kargman': [4469], 'Possibly,': [4570], 'factors': [4629], '(42Mestre': [4630], '2890-2895PubMed': [4648], 'cytokines': [4652], '(6Rimarachin': [4653], 'Scholar)': [4672], 'after': [4686], 'link': [4695], 'relationship': [4698], 'function': [4701], 'cancer.': 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