Title: Fluoxetine and norfluoxetine are potent inhibitors of P450IID6‐the source of the sparteine/debrisoquine oxidation polymorphism [letter]
Abstract: British Journal of Clinical PharmacologyVolume 32, Issue 1 p. 136-137 Free Access Fluoxetine and norfluoxetine are potent inhibitors of P450IID6-the source of the sparteine/debrisoquine oxidation polymorphism [letter] K. Brosen, K. Brosen Research Center, Orion Pharmaceutica, Espoo, Finland.Search for more papers by this authorE. Skjelbo, E. Skjelbo Research Center, Orion Pharmaceutica, Espoo, Finland.Search for more papers by this author K. Brosen, K. Brosen Research Center, Orion Pharmaceutica, Espoo, Finland.Search for more papers by this authorE. Skjelbo, E. Skjelbo Research Center, Orion Pharmaceutica, Espoo, Finland.Search for more papers by this author First published: July 1991 https://doi.org/10.1111/j.1365-2125.1991.tb05630.xCitations: 63AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References Aranow, R. B., Hudson, J. I., Pope, H. G., Grady, T. A., Laage, T. A., Bell, I. R. & Cole, J. O. (1989). Elevated antidepressant plasma levels after addition of fluoxetine. Am. J. Psychiatry, 146, 911–913. Aronoff, G. R., Bergstrom, R. F., Pottratz, S. T., Sloan, R. S., Wolen, R. L. & Lemberger, L. (1984). Fluoxetine kinetics and protein binding in normal and impaired renal function. Clin. Pharmac. Ther., 36, 138–144. Bell, I. R. & Cole, J. O. (1988). Fluoxetine induces elevation of desipramine level and exacerbation of geriatric non-psychotic depression. J. clin. Psychopharmac., 8, 447–448. Brøsen, K. & Gram, L. F. (1989). Clinical significance of the sparteine/debrisoquine oxidation polymorphism. Eur. J. clin. Pharmac., 36, 537–547. Brøsen, K., Gram, L. F. & Kragh-Sørensen, P. (1991a). Extremely slow metabolism of amitriptyline but normal metabolism of imipramine and desipramine in an extensive metabolizer of sparteine, debrisoquine and mephenytoin. Ther. Drug. Monit. (in press). Brøsen, K., Otton, S. V. & Gram, L. F. (1986). Imipramine demethylation and hydroxylation: Impact of the sparteine oxidation phenotype. Clin. Pharmac. Ther., 40, 543–549. Brøsen, K., Zeugin, T. & Meyer, V. A. (1991b). Role of P450IID6, the target of the sparteine/debrisoquin oxidation polymorphism, in the metabolism of imipramine. Clin. Pharmac. Ther., (in press). Cowley, G., Springen, K., Leonard, E. A., Robins K. & Gordon, J. (1990). The promise of Prozac. Newsweek (March 26), 38–41. Eichelbaum, M., Spannbrucker, N., Steincke, B. & Dengler, H. J. (1979). Defective N-oxidation of sparteine in man: A new pharmacogenetic defect. Eur. J. clin. Pharmac., 16, 183–187. Evans, D. A. P., Mahgoub, A., Sloan, T. P., Idle, J. R. & Smith, R. L. (1980). A family and population study of genetic polymorphism of debrisoquine oxidation in a white British population. J. med. Genet., 17, 102–105. Holford, N. (1990). MK Model Version 4. Biosoft. Cambridge, CB23 1JP, UK: Cambridge University Press. Syvalathi, E. K. G., Lindberg, J., Kallio, J. & DE Vocht, M. (1986). Inhibitory effects of neuroleptics on debrisoquine oxidation in man. Br. J. clin. Pharmac., 22, 89–92. The Medical Letter (1990). Fluoxetine (Prozac) revisited. The Medical Letter Inc. 1000 Main Street, New Rochelle, N. Y. 10801 32, 83–85. Vaughan, D. A. (1988). Interaction of fluoxetine with tricyclic antidepressants. Am. J. Psychiatry, 145, 1478. Zeugin, T. B., Brøsen, K. & Meyer, U. A. (1990). Determination of imipramine and seven of its metabolites in human liver microsomes by a high-performance liquid chromatographic method. Anal. Biochem., 189, 99–102. Citing Literature Volume32, Issue1July 1991Pages 136-137 ReferencesRelatedInformation