Human Papillomavirus E7 Requires the Protease Calpain to Degrade the Retinoblastoma Protein

Name: Work Video:
Duration: 3 min 30 s
Grant A. Darnell; Wayne A. Schroder; Toni Antalis; Eleanore Lambley; Lee Major; Joy Gardner; Geoffrey W. Birrell; Ángel Cid-Arregui; Andreas Suhrbier
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'https://openalex.org/W2167777549', 'https://openalex.org/W2169436026', 'https://openalex.org/W2169681364', 'https://openalex.org/W2321751614'], 'related_works': ['https://openalex.org/W4211046008', 'https://openalex.org/W3092184089', 'https://openalex.org/W2953425272', 'https://openalex.org/W2187684008', 'https://openalex.org/W2107866180', 'https://openalex.org/W2078990441', 'https://openalex.org/W2062123110', 'https://openalex.org/W2053984905', 'https://openalex.org/W2025982955', 'https://openalex.org/W2023204707'], 'abstract_inverted_index': {'Cervical': [0, 122], 'cancers': [1, 123], 'transformed': [2, 124], 'by': [3, 125, 477, 538, 654, 874, 979, 1090, 1139, 1342, 1451, 1723, 1755, 1866, 2145, 2269, 2370, 2406, 2699, 2770, 2988, 3098, 3199, 3247, 3376, 3428, 3475, 3485, 3605, 3712, 3758, 4171, 4269, 4303], 'high': [4, 126, 246, 3407, 4054, 4253], 'risk': [5, 127, 247], 'human': [6, 128, 248, 759, 2510], 'papilloma': [7, 129], 'virus': [8, 130], '(HPV)': [9, 131, 250], 'express': [10, 132, 3923], 'the': [11, 16, 19, 27, 33, 70, 79, 88, 117, 133, 138, 141, 149, 155, 192, 201, 210, 239, 273, 344, 353, 375, 379, 396, 402, 440, 524, 531, 593, 644, 658, 724, 789, 792, 819, 823, 872, 877, 939, 967, 1092, 1294, 1363, 1472, 1536, 1588, 1697, 1703, 1781, 1810, 1906, 1931, 1938, 1955, 1964, 2047, 2100, 2209, 2214, 2270, 2316, 2446, 2469, 2479, 2513, 2527, 2554, 2606, 2621, 2630, 2665, 2674, 2689, 2696, 2772, 2778, 2784, 2789, 2811, 2843, 2853, 2862, 2880, 2887, 2933, 2939, 2949, 2973, 2980, 2989, 2997, 3058, 3086, 3099, 3128, 3135, 3140, 3164, 3195, 3207, 3231, 3290, 3320, 3334, 3337, 3346, 3382, 3387, 3429, 3452, 3540, 3557, 3561, 3579, 3606, 3621, 3644, 3647, 3655, 3658, 3666, 3669, 3672, 3679, 3694, 3703, 3713, 3724, 3741, 3750, 3768, 3771, 3774, 3814, 3839, 3843, 3872, 3881, 3985, 3988, 4022, 4041, 4046, 4106, 4140, 4160, 4203, 4232, 4290, 4293, 4337, 4358, 4374, 4379], 'E7': [12, 38, 76, 134, 160, 198, 392, 478, 500, 539, 543, 586, 831, 875, 1275, 1762, 1791, 2356, 2423, 2440, 2496, 2700, 2971, 3458, 3481, 3543, 3555, 3642, 3829, 3837, 3992, 4172, 4206, 4304], 'oncoprotein,': [13, 135], 'which': [14, 136, 270, 521, 1959, 2549, 2694, 2742, 3112], 'accelerates': [15, 137], 'degradation': [17, 29, 82, 106, 139, 151, 204, 228, 398, 475, 591, 648, 668, 735, 825, 879, 933, 2311, 2448, 2921, 3343, 3489, 3559, 3645, 3673, 3743, 3776, 3808, 3823, 3841, 3877, 4170, 4302], 'of': [18, 30, 50, 83, 90, 107, 119, 140, 152, 172, 205, 212, 229, 241, 267, 278, 341, 343, 378, 389, 395, 399, 447, 473, 526, 646, 649, 669, 736, 772, 777, 826, 842, 876, 880, 890, 934, 941, 946, 969, 1212, 1308, 1332, 1365, 1737, 1759, 1768, 1812, 1933, 1941, 2050, 2133, 2204, 2211, 2233, 2312, 2315, 2319, 2375, 2449, 2454, 2481, 2485, 2500, 2517, 2521, 2529, 2540, 2561, 2571, 2598, 2608, 2691, 2781, 2792, 2824, 2836, 2855, 2906, 2922, 2932, 2938, 2976, 2992, 3016, 3085, 3103, 3120, 3127, 3143, 3148, 3166, 3322, 3326, 3336, 3344, 3384, 3451, 3466, 3548, 3560, 3581, 3646, 3657, 3668, 3744, 3752, 3770, 3777, 3792, 3809, 3833, 3842, 3875, 3878, 3883, 3934, 3951, 3987, 4026, 4031, 4049, 4057, 4137, 4142, 4196, 4205, 4248, 4292, 4296, 4349, 4373], 'retinoblastoma': [20, 142, 403, 761], 'protein': [21, 143, 404, 1800, 2383, 2419, 3009, 3157, 3177, 3372, 3389, 3689, 3754, 3794, 4366], '(Rb).': [22, 144], 'Here': [23, 145], 'we': [24, 146, 815], 'show': [25, 147], 'that': [26, 148, 311, 657, 721, 731, 818, 857, 2439, 2471, 2578, 2629, 2912, 2970, 2979, 3060, 3101, 3206, 3289, 3416, 3440, 3449, 3480, 3542, 3641, 3738, 3806, 3821, 3871, 4007, 4021, 4045, 4105, 4124, 4241, 4336, 4364], 'E7-mediated': [28, 54, 105, 150, 176, 227, 647, 667, 824, 932, 2231, 2310, 3324, 3421, 3662, 3775, 3807, 3822, 3876], 'Rb': [31, 108, 153, 230, 438, 474, 503, 549, 588, 650, 670, 827, 1250, 1333, 1348, 1474, 1590, 2313, 2366, 2382, 2418, 2450, 2455, 2477, 2486, 2524, 2533, 2557, 2585, 2642, 2657, 2666, 2722, 2766, 2858, 2864, 2882, 2904, 2925, 2935, 2943, 2977, 2982, 3008, 3018, 3088, 3122, 3149, 3318, 3327, 3329, 3371, 3462, 3467, 3483, 3549, 3597, 3624, 3626, 3696, 3879, 4027, 4050, 4060, 4107, 4126, 4169, 4197, 4200, 4249, 4297, 4301, 4338, 4365], 'requires': [32, 154, 2441], 'calcium-activated': [34, 156, 773], 'cysteine': [35, 157, 774], 'protease,': [36, 158], 'calpain.': [37, 159], 'bound': [39, 161, 1748], 'and': [40, 43, 93, 109, 162, 165, 215, 231, 371, 384, 391, 401, 451, 528, 544, 726, 752, 780, 785, 791, 836, 839, 927, 948, 1022, 1053, 1105, 1132, 1210, 1214, 1254, 1284, 1304, 1403, 1493, 1612, 1689, 1707, 1721, 1732, 1747, 1753, 1761, 1780, 1793, 1842, 1864, 1912, 1954, 2040, 2063, 2109, 2115, 2121, 2197, 2244, 2257, 2266, 2321, 2365, 2515, 2733, 2783, 2798, 2803, 2833, 2838, 2872, 2896, 2941, 2965, 2978, 3109, 3168, 3197, 3221, 3238, 3299, 3363, 3370, 3553, 3569, 3577, 3598, 3627, 3652, 3681, 3708, 3732, 3734, 3786, 3803, 3835, 3855, 3922, 4015, 4119, 4198, 4260], 'activated': [41, 163], 'μ-calpain': [42, 164, 779, 838, 1915, 2511], 'promoted': [44, 78, 166, 200, 840], 'cleavage': [45, 58, 167, 180, 841, 859, 1367, 1935, 2499, 2633, 2975, 3209, 3245, 3291, 3315, 3443, 3547, 3563, 3649, 3832, 3845, 4025, 4348], 'at': [46, 168, 1299, 1380, 1852, 2186, 2218, 3180, 3296, 3301, 3406, 3455, 3469, 3550, 3586, 3699], 'Rb810,': [47, 169], 'with': [48, 95, 170, 217, 245, 950, 1293, 1314, 1346, 1357, 1416, 1471, 1482, 1535, 1643, 1776, 1786, 1803, 1859, 1927, 1937, 1943, 2046, 2224, 2396, 2408, 2433, 2464, 2508, 2535, 2614, 2673, 2810, 2819, 2842, 2886, 2954, 2961, 2996, 3106, 3353, 3620, 3909, 3976, 4040, 4310], 'mutation': [49, 171, 3450], 'this': [51, 173, 858, 2564, 2856, 2923, 3017, 3170, 3349, 3888, 3937, 3967, 4125], 'residue': [52, 174, 3339, 3454, 3660, 3990], 'preventing': [53, 175], 'degradation.': [55, 177, 3422, 3463, 3663], 'The': [56, 178, 471, 582, 868, 1012, 2250, 2519, 2559, 2583, 3189, 4135, 4245], 'calpain': [57, 179, 829, 1336, 1366, 1425, 1438, 1760, 1805, 1901, 1908, 1921, 1934, 1957, 1982, 2212, 2305, 2402, 2442, 2472, 2522, 2581, 2599, 2617, 2632, 3064, 3110, 3167, 3208, 3244, 3314, 3562, 3648, 3844, 3892, 4024, 4270], 'product,': [59, 181, 3564, 3650, 3846], 'Rb1–810,': [60, 182, 3602, 3628, 3651, 3778], 'was': [61, 183, 651, 663, 832, 849, 861, 1061, 1088, 1217, 1291, 1310, 1323, 1344, 1496, 1691, 1739, 1801, 1856, 1903, 1925, 1960, 1968, 1987, 2061, 2068, 2124, 2143, 2358, 2404, 2506, 2587, 2624, 2671, 2768, 2945, 3020, 3151, 3173, 3192, 3211, 3309, 3351, 3392, 3404, 3418, 3425, 3618, 3676, 3709, 3780, 3969, 3974, 3997, 4009], 'unable': [62, 184, 850, 3459, 3898, 3998, 4010], 'to': [63, 72, 185, 194, 317, 349, 352, 481, 523, 554, 665, 834, 845, 851, 863, 930, 956, 1702, 1963, 1995, 2199, 2302, 2444, 2523, 2563, 2602, 2687, 3006, 3057, 3175, 3215, 3355, 3420, 3460, 3538, 3678, 3723, 3782, 3899, 3942, 3999, 4011, 4034, 4059, 4144, 4159, 4167, 4354, 4370], 'mediate': [64, 186, 2445, 3904], 'cell': [65, 187, 453, 532, 853, 1457, 1606, 2135, 2492, 2739, 2806, 2840, 2877, 2901, 3920], 'cycle': [66, 188, 454, 854], 'arrest': [67, 189, 455], 'but': [68, 190, 2818, 2860, 2927, 3600, 3629, 3693], 'retained': [69, 191], 'ability': [71, 193, 4141], 'repress': [73, 195, 4371], 'E6/E7': [74, 196, 2743, 4376], 'transcription.': [75, 197], 'also': [77, 199, 937, 2467, 2588, 2593, 2816, 3003, 3062, 3091, 3310, 3426, 3956, 4114, 4193], 'accelerated': [80, 202, 397, 590, 2447], 'proteasomal': [81, 203, 878, 2844, 2998, 3488, 3558, 3742, 3840], 'Rb1–810.': [84, 206, 847, 881, 3565, 3745, 3847], 'Calpain': [85, 207, 882, 960, 1330, 1897, 2227, 2483], 'inhibitors': [86, 208, 883, 961], 'reduced': [87, 209, 938, 3013, 3936], 'viability': [89, 211, 940, 1458], 'HPV-transformed': [91, 213, 942, 2663, 2678, 2900], 'cells': [92, 214, 673, 943, 1014, 1464, 1528, 1640, 1651, 1710, 1727, 1773, 2005, 2042, 2190, 2328, 2388, 2670, 2684, 2731, 2995, 3105, 3396, 3686, 3783, 3913, 3955, 4113, 4152], 'synergized': [94, 216, 949], 'cisplatin.': [96, 218], 'Calpain,': [97, 219], 'thus,': [98, 220, 963, 3536], 'emerges': [99, 221], 'as': [100, 222, 542, 1024, 1219, 1498, 1566, 1615, 1734, 1869, 2002, 2070, 2150, 2236, 2422, 3153, 3312, 3706], 'a': [101, 111, 223, 233, 304, 483, 770, 888, 952, 1560, 1567, 1598, 1913, 1971, 2127, 2239, 2245, 2307, 2409, 2491, 2530, 2536, 2655, 2720, 2736, 2820, 2849, 3012, 3145, 3154, 3313, 3825, 3918, 4252], 'central': [102, 224, 351], 'player': [103, 225], 'in': [104, 226, 322, 374, 445, 671, 788, 822, 966, 1334, 1362, 1388, 1411, 1480, 1654, 1809, 1930, 1984, 2007, 2193, 2264, 2309, 2326, 2385, 2456, 2475, 2478, 2487, 2490, 2512, 2526, 2567, 2605, 2626, 2639, 2646, 2662, 2668, 2677, 2728, 2741, 2848, 2852, 2875, 2899, 3118, 3132, 3317, 3319, 3348, 3394, 3573, 3578, 3671, 3727, 3773, 3790, 3953, 3958, 4029, 4110, 4149, 4202, 4266, 4308], 'represents': [110, 232, 4128], 'potential': [112, 234, 4339], 'new': [113, 235, 641], 'drug': [114, 236, 953], 'target': [115, 237], 'for': [116, 238, 263, 589, 757, 887, 1249, 1296, 1377, 1456, 1610, 1849, 2057, 2105, 2111, 2117, 2230, 2255, 2261, 3230, 3243, 3341, 3661, 3851, 3991, 4053, 4236, 4243, 4345], 'treatment': [118, 240, 968, 1313, 3102, 3760], 'HPV-associated': [120, 242], 'lesions.': [121, 243], 'Infection': [244], 'Papillomavirus': [249, 760], '2The': [251], 'abbreviations': [252], 'used': [253, 955, 1192, 1961, 2099, 2301, 2686], 'are:': [254], 'HPVhuman': [255], 'PapillomavirusRbretinoblastomaGSTglutathione': [256], 'S-transferaseSAsenescence-activatedURRupstream': [257], 'regulatory': [258, 766, 1269, 2248], 'region': [259, 767, 3224, 4048, 4247, 4295], 'types': [260], 'is': [261, 271, 347, 393, 479, 536, 2253, 2259, 2267, 2473, 2643, 2695, 2745, 2913, 2984, 3096, 3721, 3811, 3824, 4038, 4051, 4342, 4368], 'responsible': [262], 'virtually': [264], 'all': [265], 'cases': [266], 'cervical': [268, 958, 2993], 'cancer,': [269], 'currently': [272], 'second': [274, 583, 869], 'most': [275], 'common': [276], 'cause': [277], 'death': [279], 'from': [280, 866, 1018, 1063, 1095, 1136, 1693, 1708, 2004, 2297, 2553, 3194, 3885, 4357, 4378], 'cancer': [281, 893, 2994], 'among': [282], 'women': [283], 'worldwide': [284], '(1Lowy': [285], 'D.R.': [286], 'Schiller': [287], 'J.T.': [288, 918], 'J.': [289, 460, 566, 611, 707, 798, 920, 1077, 1119, 1150, 1511, 1550, 1578, 1626, 2162, 2169, 2755, 3024, 3267, 3506, 4088, 4181, 4324, 4391], 'Clin.': [290], 'Investig.': [291], '2006;': [292, 333, 363, 569, 899, 922], '116:': [293], '1167-1173Crossref': [294], 'PubMed': [295, 366, 418, 432, 466, 494, 516, 577, 605, 622, 694, 712, 809, 902, 1007, 1046, 1082, 1124, 1155, 1185, 1241, 1516, 1555, 1583, 1631, 1684, 1892, 2030, 2092, 2175, 2289, 2345, 2713, 2760, 3035, 3078, 3278, 3500, 3517, 3865, 4078, 4099, 4186, 4227, 4284, 4329, 4396], 'Scopus': [296, 336, 367, 419, 433, 467, 495, 517, 578, 606, 623, 695, 713, 810, 903, 1008, 1047, 1083, 1125, 1156, 1186, 1242, 1517, 1556, 1584, 1632, 1685, 1893, 2031, 2093, 2176, 2290, 2346, 2714, 2761, 3036, 3079, 3279, 3501, 3518, 3866, 4079, 4100, 4187, 4228, 4285, 4330, 4397], '(315)': [297], 'Google': [298, 338, 369, 421, 435, 469, 497, 519, 580, 608, 625, 638, 697, 715, 812, 905, 925, 1010, 1049, 1085, 1127, 1158, 1188, 1244, 1519, 1558, 1586, 1634, 1687, 1895, 2033, 2095, 2178, 2292, 2348, 2716, 2763, 3038, 3051, 3081, 3281, 3503, 3520, 3533, 3868, 4081, 4102, 4189, 4230, 4287, 4332, 4399], 'Scholar).': [299, 339, 436, 470, 498, 581, 639, 716, 813, 1011, 1050, 1086, 1128, 1159, 1189, 1520, 1635, 1896, 2034, 2096, 2179, 2293, 2717, 2764, 3052, 3534, 4082, 4190, 4288, 4333, 4400], 'Vaccination': [300], 'will': [301], 'likely': [302], 'have': [303, 550, 1107, 3478, 4361], 'substantial': [305, 2850], 'impact;': [306], 'however,': [307], 'current': [308], 'modeling': [309], 'suggests': [310, 3288, 4020, 4335], 'it': [312, 727, 3417], 'may': [313, 3054], 'take': [314], '40–50': [315], 'years': [316], 'reach': [318], 'an': [319, 2591, 2610, 2903, 3226], '≈50%': [320], 'reduction': [321], 'mortality': [323], '(2Garnett': [324], 'G.P.': [325], 'Kim': [326], 'J.J.': [327], 'French': [328], 'K.': [329, 424, 509, 563, 1175, 1510, 2158, 2166, 2280, 2336, 2706, 4323], 'Goldie': [330], 'S.J.': [331], 'Vaccine.': [332], '24:': [334, 492, 3863], '178-186Crossref': [335], '(150)': [337], 'Integration': [340], 'part': [342], 'HPV': [345, 970, 2647, 4359, 4381], 'genome': [346], 'believed': [348, 480], 'be': [350, 555, 2551, 2660, 2725, 2884, 2910, 3055, 3092, 3748, 3897], 'transformation': [354], 'process': [355, 485], '(3Hebner': [356], 'C.M.': [357], 'Laimins': [358, 409], 'L.A.': [359, 410], 'Rev.': [360, 414], 'Med.': [361, 2171], 'Virol.': [362, 708, 1078, 1120, 1151, 1512, 1551, 1579, 1627, 2756, 4182, 4325, 4392], '16:': [364], '83-97Crossref': [365], '(264)': [368], 'Scholar)': [370, 926, 1245, 3282, 3869, 4103], 'often': [372, 4264], 'results': [373, 4028], 'increased': [376, 2425], 'expression': [377, 1057, 1591, 2377, 2931, 3390, 3940, 3996, 4002, 4136, 4235, 4367], 'two': [380, 776], 'viral': [381], 'oncoproteins,': [382], 'E6': [383, 390], 'E7.': [385], 'A': [386, 640, 2350, 2964, 3220], 'principle': [387], 'activity': [388, 1614, 1902, 1909, 1983, 2263, 2403, 2443, 2592, 4014], 'promotion': [394, 472, 873], 'p53': [400, 947, 1162, 1266, 2207], '(Rb),': [405, 3567], 'respectively': [406], '(4Longworth': [407], 'M.S.': [408], 'Microbiol.': [411], 'Mol.': [412, 688, 1040, 1180, 1235, 1678, 1886, 2024, 2086, 2283, 2339, 4221], 'Biol.': [413, 567, 601, 690, 799, 1042, 1237, 1680, 1888, 2026, 2088, 2285, 2341, 3268, 3496, 4223], '2004;': [415, 463, 3270], '68:': [416], '362-372Crossref': [417], '(490)': [420], 'Scholar,': [422, 609, 626, 698, 906, 3039, 3504, 3521], '5Munger': [423], 'Howley': [425, 506, 2703], 'P.M.': [426, 507, 2704], 'Virus': [427], 'Res.': [428, 634, 1002, 3047, 3529], '2002;': [429, 1004, 3075], '89:': [430], '213-228Crossref': [431], '(614)': [434], 'Hypophosphorylated': [437], 'binds': [439, 501, 2776, 2788], 'E2F': [441, 527, 535, 545, 865, 3884, 3901, 4013, 4032, 4058], 'transcription': [442, 450, 2744, 4372], 'factor,': [443], 'resulting': [444], 'repression': [446], 'E2F-dependent': [448], 'gene': [449, 1094, 2272], 'G1': [452], '(6Frolov': [456], 'M.V.': [457], 'Dyson': [458], 'N.J.': [459, 598, 3493], 'Cell': [461, 973, 1054, 2139, 2180, 2648, 3073], 'Sci.': [462, 4277], '117:': [464], '2173-2181Crossref': [465], '(331)': [468], 'mediated': [476], 'involve': [482], 'two-step': [484, 3826], '(7Helt': [486, 3857], 'A.M.': [487, 3858], 'Galloway': [488, 3856, 3859], 'D.A.': [489, 3860], 'Carcinogenesis.': [490, 3861], '2003;': [491, 602, 691, 1043, 1079, 1182, 1238, 1681, 1889, 2027, 2089, 3497, 3862, 4224], '159-169Crossref': [493, 3864], '(218)': [496, 3867], 'First,': [499, 3828], 'hypophosphorylated': [502, 2692], '(8Dyson': [504, 2701], 'N.': [505, 908, 991, 2702, 4066], 'Munger': [508, 1509, 2705, 4322], 'Harlow': [510, 2707], 'E.': [511, 912, 2708], 'Science.': [512, 2709], '1989;': [513, 2710], '243:': [514, 2711], '934-937Crossref': [515, 2712], '(2398)': [518, 2715], 'Scholar),': [520, 1559, 1587, 1688, 3082, 4231], 'leads': [522], 'displacement': [525], 'entry': [529], 'into': [530, 643, 1097, 2183, 2360, 3367], 'cycle.': [533], 'How': [534], 'displaced': [537], 'remains': [540], 'unclear': [541], 'binding': [546, 4033, 4056], 'sites': [547], 'on': [548, 2126, 2381, 3813], 'recently': [551, 652, 729], 'been': [552, 1067, 1108, 1165, 3004, 4165], 'shown': [553, 833, 3005, 4166, 4363], 'quite': [556], 'distinct': [557], '(9Liu': [558], 'X.': [559, 1506, 4319], 'Clements': [560], 'A.': [561, 613, 687, 706, 743, 750, 1039, 1071, 1118, 1149, 1234, 1549, 1577, 1625, 1677, 1885, 2023, 2085, 2168, 2754, 3026, 3256, 3258, 3260, 3508, 4090, 4180, 4220, 4390], 'Zhao': [562], 'Marmorstein': [564], 'R.': [565, 910], 'Chem.': [568, 800, 3269], '281:': [570], '578-586Abstract': [571], 'Full': [572, 574, 804, 806, 3273, 3275, 4073, 4075, 4281], 'Text': [573, 575, 805, 807, 3274, 3276, 4074, 4076, 4282], 'PDF': [576, 808, 3277, 4077, 4283], '(177)': [579], 'step': [584, 821, 870], 'involves': [585, 828, 3880, 3891], 'targeting': [587], 'via': [592], 'proteasome': [594, 3670, 3772], '(10Scheffner': [595, 3490], 'M.': [596, 747, 754, 993, 1504, 2156, 3070, 3491, 4272, 4317], 'Whitaker': [597, 3492], 'Semin.': [599, 3494], 'Cancer': [600, 633, 3046, 3495, 3528], '13:': [603, 3498], '59-67Crossref': [604, 3499], '(137)': [607, 3502], '11Wang': [610, 3505], 'Sampath': [612, 3025, 3507, 4089], 'Raychaudhuri': [614, 3027, 3509, 4091], 'P.': [615, 989, 1177, 1179, 3028, 3252, 3254, 3266, 3510, 4092], 'Bagchi': [616, 3029, 3511, 4093], 'S.': [617, 740, 748, 1169, 1173, 3030, 3512, 4094], 'Oncogene.': [618, 3031, 3513, 4095], '2001;': [619, 1513, 3032, 3514, 4096, 4326], '20:': [620, 2287, 2343, 3033, 3515, 4097], '4740-4749Crossref': [621, 3034, 3516, 4098], '(97)': [624, 3037, 3519, 4101], '12Boyer': [627, 3040, 3522], 'S.N.': [628, 3041, 3072, 3523], 'Wazer': [629, 3042, 3524], 'D.E.': [630, 3043, 3525], 'Band': [631, 3044, 3526], 'V.': [632, 1073, 3045, 3527], '1996;': [635, 3048, 3530, 4278], '56:': [636, 3049, 3531], '4620-4624PubMed': [637, 3050, 3532], 'insight': [642], 'mechanism': [645], 'provided': [653, 978], 'our': [655], 'observation': [656, 2611, 3100, 4037], 'serine': [659], 'protease': [660, 1397, 1658, 1843, 1991, 2262], 'inhibitor': [661, 1398, 1426, 1439, 1659, 1844, 2845, 2999], 'SerpinB2': [662, 722, 732, 1106, 1487, 4138, 4163, 4192, 4239], 'able': [664, 929, 4369], 'inhibit': [666, 931, 4012, 4145, 4168], 'HeLa': [672, 1709, 1772, 2738, 2801, 2837, 3104, 3368, 3395], '(13Darnell': [674, 1026, 1221, 1664, 1872, 2010, 2072, 4207], 'G.A.': [675, 700, 1027, 1112, 1143, 1222, 1543, 1571, 1619, 1665, 1873, 2011, 2073, 2748, 4174, 4208, 4384], 'Antalis': [676, 701, 1028, 1113, 1144, 1223, 1544, 1572, 1620, 1666, 1874, 2012, 2074, 2749, 4175, 4209, 4385], 'T.M.': [677, 702, 1029, 1114, 1145, 1224, 1545, 1573, 1621, 1667, 1875, 2013, 2075, 2153, 2750, 4176, 4210, 4386], 'Johnstone': [678, 1030, 1225, 1668, 1876, 2014, 2076, 4211], 'R.W.': [679, 1031, 1226, 1669, 1877, 2015, 2077, 4212], 'Stringer': [680, 1032, 1227, 1670, 1878, 2016, 2078, 4213], 'B.W.': [681, 1033, 1228, 1671, 1879, 2017, 2079, 4214], 'Ogbourne': [682, 1034, 1229, 1672, 1880, 2018, 2080, 4215], 'S.M.': [683, 1035, 1230, 1673, 1881, 2019, 2081, 4062, 4216], 'Harrich': [684, 1036, 1231, 1674, 1882, 2020, 2082, 4217], 'D.': [685, 1037, 1232, 1675, 1883, 2021, 2083, 4218], 'Suhrbier': [686, 705, 1038, 1117, 1148, 1233, 1548, 1576, 1624, 1676, 1884, 2022, 2084, 2167, 2753, 4179, 4219, 4389], 'Cell.': [689, 1041, 1236, 1679, 1887, 2025, 2087, 2284, 2340, 4069, 4222], '23:': [692, 1044, 1239, 1682, 1890, 2028, 2090, 4225], '6520-6532Crossref': [693, 1045, 1240, 1683, 1891, 2029, 2091, 4226], '(64)': [696, 1048, 1243, 1686, 1894, 2032, 2094, 4229], '14Darnell': [699], 'Rose': [703, 1115, 1146, 1546, 1574, 1622, 2751, 4177, 4387], 'B.R.': [704, 1116, 1147, 1547, 1575, 1623, 2752, 4178, 4388], '2005;': [709, 801, 1121, 1152, 1552, 1580, 1628, 2757, 4070, 4183, 4393], '79:': [710, 1122, 1153, 1553, 1581, 1629, 2758, 4184, 4394], '4246-4256Crossref': [711, 1123, 1154, 1554, 1582, 1630, 2759, 4185, 4395], '(11)': [714, 1126, 1157, 1557, 1585, 1633, 2762, 4188, 4398], 'There': [717], 'are': [718, 782, 884, 2323, 2600, 2635, 4263], 'no': [719, 3441], 'reports': [720, 4043], 'inhibits': [723, 733, 3063, 4194], 'proteasome,': [725], 'has': [728, 1066, 1164, 3001, 4164], 'emerged': [730], 'calpain-mediated': [734, 2498, 2974, 3546, 3831, 4347], 'Rb.': [737, 867, 935, 3886, 4035, 4350], '3L.': [738], 'Tonnetti,': [739], 'Netzel-Arnett,': [741], 'G.': [742], 'Darnell,': [744], 'T.': [745, 753], 'Hayes,': [746], 'Buzza,': [749], 'Suhrbier,': [751], 'Antalis,': [755], 'submitted': [756], 'publication.': [758], 'glutathione': [762], 'S-transferase': [763], 'senescence-activated': [764, 1494], 'upstream': [765], 'Calpains': [768], 'represent': [769], 'group': [771], 'proteases,': [775], 'which,': [778], 'm-calpain,': [781, 2258], 'ubiquitously': [783], 'expressed': [784, 1387, 3152, 3405, 3572, 3585], 'found': [786, 2676, 4265], 'both': [787, 2771, 3107, 3735], 'cytoplasm': [790], 'nucleus': [793], '(15Tremper-Wells': [794], 'B.': [795], 'Vallano': [796], 'M.L.': [797], '280:': [802], '2165-2175Abstract': [803], '(58)': [811], 'Herein': [814], 'provide': [816], 'evidence': [817], 'first': [820, 2952, 3544, 3873, 3889], 'cleavage.': [830], 'bind': [835, 3900, 4117], 'activate': [837], 'full-length': [843, 2503, 2556, 3121, 3910], 'Rb1–928': [844, 1138, 2505, 2572, 3362, 3388, 3566, 4155, 4237], 'yield': [846, 3176], 'Rb1–810': [848, 1133, 3570, 3785, 3793, 3810, 3848, 3895, 3995, 4008, 4129, 4351], 'promote': [852, 3461, 4016], 'arrest,': [855, 3916], 'suggesting': [856, 2577, 2628], 'event': [860], 'sufficient': [862], 'displace': [864], 'involved': [871, 2474], 'being': [885], 'developed': [886], 'number': [889], 'diseases': [891], 'including': [892], '(16Carragher': [894], 'N.O.': [895], 'Curr.': [896], 'Pharm.': [897], 'Des.': [898], '12:': [900], '615-638Crossref': [901], '(146)': [904], '17Guan': [907], 'Korukonda': [909], 'Hurh': [911], 'Schmittgen': [913], 'T.D.': [914], 'Donkor': [915], 'I.O.': [916], 'Dalton': [917], 'Int.': [919], 'Oncol.': [921], '29:': [923], '655-663PubMed': [924], 'were': [928, 977, 1016, 1134, 1196, 1386, 1414, 1448, 1466, 1491, 1530, 1608, 1641, 1652, 1718, 1730, 1750, 1763, 2000, 2044, 2181, 2216, 2300, 2368, 2685, 2808, 2815, 2951, 3365, 3374, 3571, 3584, 3603, 3632, 3691, 3755], 'They': [936], 'through': [944], 'up-regulation': [945], 'cisplatin,': [951], 'frequently': [954], 'treat': [957], 'cancer.': [959], 'may,': [962], 'find': [964], 'application': [965], 'associated': [971], 'malignancies.': [972], 'Line—CAPN4–/–': [974], 'embryonic': [975, 2295, 2363, 2459], 'fibroblasts': [976, 1637, 1695, 2296, 2460], 'John': [980], 'Elce': [981, 998, 2275, 2331], "(Queen's": [982], 'University,': [983], 'Kingston': [984], 'Canada)': [985], '(18Postovit': [986], 'L.M.': [987], 'Dutt': [988], 'Dourdin': [990], 'Park': [992], 'Greer': [994, 2281, 2337], 'P.A.': [995, 2282, 2338], 'Graham': [996], 'C.H.': [997], 'J.S.': [999, 2274, 2276, 2330, 2332], 'Biochem.': [1000, 4276], 'Biophys.': [1001], 'Commun.': [1003], '297:': [1005], '294-301Crossref': [1006], '(21)': [1009], 'remaining': [1013], 'lines': [1015, 2841, 2902], 'obtained': [1017], 'ATCC': [1019], '(Manassas,': [1020], 'VA)': [1021], 'maintained': [1023], 'described': [1025, 1068, 1109, 1166, 1220, 1499, 1616, 1870, 2003, 2071, 2151, 3246], 'DNA': [1051], 'Plasmids': [1052, 1100, 1129, 3360], 'Transfection—The': [1055], 'mammalian': [1056], 'plasmid': [1058, 1539, 1592, 1600, 2351, 2410], 'encoding': [1059, 1101, 1130, 2352, 2411, 3361], 'CAPN4': [1060, 1268, 2271, 2412], 'purchased': [1062], 'ATCC.': [1064], 'pIRES-Neo2-eE7': [1065, 1096, 1483], 'previously': [1069, 1110, 1167, 1500, 1617, 1871, 3002, 4362], '(19Cid-Arregui': [1070], 'Juarez': [1072], 'zur': [1074], 'Hausen': [1075], 'H.': [1076], '77:': [1080], '4928-4937Crossref': [1081], '(103)': [1084], 'GST-eE7': [1087, 1361, 1855, 1929, 2562], 'generated': [1089, 1135, 2637], 'subcloning': [1091], 'eE7': [1093, 2376, 2579, 2615, 3582, 3617, 3680, 3935, 3977, 4143], 'pGEX-2TK': [1098], '(Invitrogen).': [1099, 1194], 'Rb1–928,': [1102, 3345, 3688, 3928, 3947], 'Rb394–928,': [1103], 'GST-Rb768–928,': [1104], '(14Darnell': [1111, 1142, 1542, 1570, 1618, 2747, 4173, 4383], 'RbK810A': [1131, 3357, 3364, 3403, 3424, 3753, 3952, 3973], 'pCDNA3.1': [1137], 'site-directed': [1140], 'mutagenesis': [1141], 'Dominant': [1160], 'negative': [1161, 2206], '(pRc/CMV-R273H)': [1163], '(20Downing': [1168], 'Bumak': [1170], 'C.': [1171, 2278, 2334, 3068], 'Nixdorf': [1172], 'Ow': [1174], 'Russell': [1176], 'Jackson': [1178], 'Carcinog.': [1181], '38:': [1183], '130-140Crossref': [1184], '(12)': [1187], 'Vector': [1190], 'controls': [1191], 'pcDNA3.1': [1193], 'Cells': [1195, 1447, 1490], 'transfected': [1197, 1467, 1531, 1642, 1731, 2359, 3366], 'using': [1198, 1246, 1325, 1393, 1405, 1468, 1532, 1696, 1711, 1741, 1765, 1905, 1970, 1989, 2131, 4258], 'GeneJammer': [1199, 1469, 1533], 'transfection': [1200, 1568, 2203, 3908], 'reagent': [1201], '(Stratagene,': [1202], 'La': [1203, 2154], 'Jolla,': [1204], 'CA).': [1205], 'Western': [1206, 1316, 1452, 1724, 1756, 1867, 2371, 3377], 'Blots—Western': [1207], 'blot': [1208, 1317], 'analyses': [1209, 3204], 'preparation': [1211], 'nuclear': [1213, 1766, 1985], 'cellular': [1215], 'extracts': [1216, 1767, 2807], 'undertaken': [1218, 1311, 1764], 'antibodies': [1247], 'specific': [1248], '(G3–245)': [1251], '(BD': [1252], 'PharMingen)': [1253], 'C-15': [1255, 2785, 2888, 3430, 3607, 3714], '(Santa': [1256, 1277], 'Cruz': [1257], 'Biotechnology,': [1258], 'Santa': [1259], 'Cruz,': [1260], 'CA),': [1261, 1283], 'FLAG': [1262], '(Sigma-Aldrich),': [1263], 'actin': [1264], '(C-11),': [1265], '(D0–1),': [1267], 'subunit': [1270, 2243, 2252], '(N-19),': [1271, 1789, 1792], 'calpain-1': [1272], '(N-9),': [1273], 'HPV-18': [1274, 1521, 2106], '(N-19)': [1276], 'Cruz),': [1278], 'glyceraldehyde-3-phosphate': [1279, 2118, 2136], 'dehydrogenase': [1280, 2137], '(Chemicon,': [1281], 'Temecula,': [1282], 'horseradish': [1285], 'peroxidase-conjugated': [1286], 'secondary': [1287, 1305], 'antibody': [1288, 1713, 2774, 2786, 2889, 3432, 3609, 3715], '(Chemicon).': [1289], 'N19': [1290], 'incubated': [1292, 1345, 1802, 1926, 2045, 2217, 2507], 'nitrocellulose': [1295], '3': [1297, 2832], 'days': [1298], '4': [1300, 1853, 2871, 2895, 3731], '°C': [1301, 2220], 'before': [1302, 2222, 2650], 'washing': [1303], 'antibody.': [1306], 'Reprobing': [1307], 'membranes': [1309], 'after': [1312], 'Restore': [1315], 'stripping': [1318], 'buffer': [1319, 1368, 1395, 1656, 1814, 1936], '(Pierce).': [1320, 1329], 'Protein': [1321, 1327], 'loading': [1322], 'quantified': [1324, 2144], 'BCA': [1326], 'assay': [1328, 1910, 1992], 'Cleavage': [1331, 2484, 3130], 'Vitro—Recombinant': [1335], '(Sigma-Aldrich)': [1337, 1706, 1806, 1922], '(0.1': [1338, 1807, 1923], 'IU/ml,': [1339], '>98%': [1340], 'pure': [1341], 'SDS-PAGE)': [1343], 'recombinant': [1347, 1360, 1804, 1928, 2504, 2509], '(QED': [1349], 'Biosciences)': [1350, 1422], '(0.5': [1351], 'μg/ml,': [1352], '>90%': [1353], 'pure)': [1354], 'or': [1355, 1358, 1429, 1443, 1454, 1479, 1597, 1638, 1645, 1944, 1949, 2054, 2195, 3903], 'GST-Rb768–928': [1356, 3172], 'without': [1359, 1945], 'presence': [1364, 1811, 1932, 2514, 3383], '(25': [1369, 1815], 'mm': [1370, 1375, 1816, 1821, 1830], 'Tris,': [1371], 'pH': [1372, 1818], '7.0,': [1373], '100': [1374], 'NaCl)': [1376], '30': [1378], 'min': [1379], '37': [1381, 2219], '°C.': [1382, 1854], 'GST': [1383, 1796, 3155], 'fusion': [1384, 1799, 3156], 'proteins': [1385, 1717, 1749, 4267], 'XL-10': [1389], 'Blue': [1390], '(Stratagene),': [1391], 'extracted': [1392], 'lysis': [1394, 1655], 'containing': [1396, 1657], 'mixture': [1399, 1660, 2565], '(Roche': [1400, 1661, 1846], 'Applied': [1401, 1662, 1847], 'Science),': [1402], 'purified': [1404, 2502], 'glutathione-agarose': [1406, 1860], 'beads': [1407, 1744], '(Sigma-Aldrich).': [1408, 1446, 1715], 'Drug': [1409], 'Treatments': [1410], 'Vitro—Cells': [1412], '(105)': [1413, 1465, 1529], 'treated': [1415, 2953], '(i)': [1417], 'lactacystin': [1418, 1779, 2846, 2919, 3108, 3675, 3759, 3779], '10': [1419, 1777], 'μm': [1420, 1778], '(EMD': [1421, 1435, 1441, 1745, 1918], 'overnight,': [1423], '(ii)': [1424], 'PD': [1427, 1433, 1950, 2052, 2055], '150606': [1428, 1951, 2053], 'its': [1430, 2915, 3487], 'inactive': [1431], 'homologue': [1432], '145305': [1434], 'Biosciences),': [1436, 1442, 1746], '(iii)': [1437], 'VI': [1440], '(iv)': [1444], 'cisplatin': [1445], 'then': [1449, 1857, 2985, 3554, 3836, 3894], 'analyzed': [1450, 1609, 1754, 1865, 3198, 3375], 'blotting': [1453, 1868], 'assayed': [1455], '(see': [1459, 4130], 'below).': [1460], 'Senescence-activated': [1461], 'β-Galactosidase': [1462], 'Assay—SAOS-2': [1463], '(Stratagene)': [1470, 1534], 'indicated': [1473, 1589, 1939, 2048, 2438], 'plasmids': [1475], '(0.6': [1476, 1484, 1488, 1540, 1564, 1593, 1601], 'μg)': [1477, 1485, 1541, 1565], 'alone': [1478], 'combination': [1481], 'and/or': [1486, 2208], 'μg).': [1489, 1602], 'grown,': [1492], '(SA)-β-galactosidase': [1495], 'detected': [1497, 1722, 2625, 2727, 2769, 2817, 2885, 2911, 3427], '(21Gonzalez': [1501, 4314], 'S.L.': [1502, 4315], 'Stremlau': [1503, 4316], 'He': [1505, 4318], 'Basile': [1507, 4320], 'J.R.': [1508, 4321], '75:': [1514, 4327], '7583-7591Crossref': [1515, 4328], '(245)': [1518, 4331], 'Upstream': [1522], 'Regulatory': [1523], 'Region': [1524], '(URR)': [1525], 'Luciferase': [1526], 'Assays—SAOS-2': [1527], 'HPV-URR': [1537], 'reporter': [1538], 'pCMV': [1561], 'β-galactosidase': [1562, 1613, 4147], 'construct': [1563], 'control': [1569, 1599, 2669, 2729, 3943], 'μg),': [1594], 'plus': [1595], 'pIRES-neo2-eE7': [1596, 1644], 'At': [1603], '72-h': [1604], 'post-transfection': [1605], 'lysates': [1607, 1986], 'luciferase': [1611], 'Immunoprecipitation—CAPN4–/–': [1636], 'HEK293': [1639, 1726], 'HIS-eE7-FLAG,': [1646], 'respectively.': [1647], 'After': [1648, 2202, 3907], '48–72': [1649], 'h': [1650, 1851], 'lysed': [1653, 1733], 'Science)': [1663], 'FLAG-eE7': [1690], 'immunoprecipitated': [1692], 'CAPN4–/–': [1694, 2298, 2361, 2457], 'FLAG™': [1698], 'immunoprecipitation': [1699, 1783], 'kit': [1700, 1784, 1911], 'according': [1701, 1962, 1994], "manufacturer's": [1704, 1965, 1996], 'instructions': [1705], 'anti-FLAG': [1712], 'M2': [1714], 'Bound': [1716], 'washed,': [1719, 1751, 1862], 'eluted,': [1720, 1752, 1863], 'blotting.': [1725, 1757, 2372], 'expressing': [1728, 3687, 3784], 'HIS-eE7-FLAG': [1729, 1738], 'above.': [1735], 'Pulldown': [1736], 'performed': [1740, 2069], 'nickel-nitrilotriacetic': [1742], 'acid-agarose': [1743], 'Immunoprecipitation': [1758], '≈107': [1769], 'fully': [1770], 'confluent': [1771], 'cultured': [1774], 'overnight': [1775, 2221], 'Seize': [1782], '(Pierce)': [1785], 'goat': [1787], 'anti-calpain-1': [1788], '-HPV-18': [1790], '-actin': [1794], '(C-11).': [1795], 'Binding': [1797], 'Assays—GST-eE7': [1798], 'IU/ml)': [1808, 1924], 'LICHT': [1813], 'Hepes,': [1817], '7.5,': [1819], '2.5': [1820], 'MgCl2,': [1822], '20%': [1823], '(v/v)': [1824, 1827], 'glycerol,': [1825], '0.1%': [1826], 'NP40,': [1828], '150': [1829, 1832], 'KCl,': [1831], 'pg/ml': [1833], 'bovine': [1834], 'serum': [1835], 'albumin': [1836], '(Sigma),': [1837, 1841], '0.1': [1838], 'm': [1839], 'dithiothreitol': [1840], 'cocktail': [1845], 'Science))': [1848], '2': [1850, 2187], 'captured': [1858], 'beads,': [1861], 'Activity': [1898], 'Assays—In': [1899], 'vitro': [1900, 2640], 'determined': [1904, 2369], 'fluorogenic': [1907, 1914, 1956], 'substrate': [1916], 'H-K(FAM)-EVY∼GMMK(DABCYL)-OH': [1917], 'Biosciences).': [1919], 'Recombinant': [1920], 'concentration': [1940], 'calcium': [1942], 'EGTA': [1946], '(10': [1947], 'mm)': [1948], '(150': [1952], 'μm)': [1953], 'substrate,': [1958], 'instructions.': [1966, 1997], 'Fluorescence': [1967], 'measured': [1969, 1988], 'FLUROstar': [1972], 'Optima': [1973], 'fluorometer': [1974], '(BMC': [1975], 'Lab': [1976], 'tech,': [1977], 'Offen-burg,': [1978], 'Germany).': [1979], 'In': [1980, 2399, 3401, 3685, 4401], 'vivo': [1981], 'Calpain-Glo™': [1990], '(Promega)': [1993], 'Nuclear': [1998], 'lysate': [1999], 'prepared': [2001], 'washed': [2006], 'phosphate-buffered': [2008], 'saline': [2009], 'Quantitative': [2035], 'Real': [2036], 'Time': [2037], 'Reverse': [2038], 'Transcription-PCR—HeLa': [2039], 'Caski': [2041, 2804, 2839, 4112], '(106)': [2043], 'concentrations': [2049], 'either': [2051], '14305': [2056], '5': [2058], 'days.': [2059], 'cDNA': [2060], 'prepared,': [2062], 'real': [2064], 'time': [2065], 'reverse': [2066], 'transcription-PCR': [2067], 'PCR': [2097], 'analysis': [2098], 'following': [2101], 'nucleotide': [2102], 'primers': [2103], '(Sigma-Aldrich);': [2104], 'E7,': [2107, 2113, 3386], '5′-GCTGAACCACAACGTCACAC-3′': [2108], '5′-GGTCGTCTGCTGGAGCTTTCT-3′;': [2110], 'HPV-16': [2112, 2355], '5′-CCGGACAGAGCCCATTACAAT-3′': [2114], '5′-ACGTGTGTGCTTTGTACGCAC-3′;': [2116], 'dehydrogenase,': [2119], '5′-GGTCGGTGTGAACGGATTT-3′': [2120], '5′-GTCGTTGATGGCAACAATCT-3′.': [2122], 'Quantitation': [2123], 'based': [2125], 'standard': [2128], 'curve': [2129], 'established': [2130], 'dilutions': [2132], 'untreated': [2134], 'cDNA.': [2138], 'Viability': [2140], 'Assays—Cell': [2141], 'survival': [2142], 'crystal': [2146, 2225], 'violet': [2147], 'staining': [2148, 2223], 'assays': [2149], '(22Antalis': [2152], 'Linn': [2155], 'Donnan': [2157], 'Mateo': [2159], 'L.': [2160], 'Gardner': [2161], 'Dickinson': [2163], 'J.L.': [2164], 'Buttigieg': [2165], 'Exp.': [2170], '1998;': [2172], '187:': [2173], '1799-1811Crossref': [2174], '(77)': [2177], 'plated': [2182], '96-well': [2184], 'plates': [2185, 2215], '×': [2188], '104': [2189], 'per': [2191], 'well': [2192], 'triplicate': [2194], 'quadruplicate': [2196], 'allowed': [2198], 'adhere': [2200], 'overnight.': [2201], 'dominant': [2205], 'addition': [2210, 2520, 2560, 3165], 'inhibitors,': [2213, 3111], 'violet.': [2226], 'Is': [2228, 3473, 3849, 4352], 'Required': [2229], 'Degradation': [2232, 3325, 3465], 'Rb—Calpains': [2234], 'exist': [2235], 'heterodimers': [2237], 'comprising': [2238], 'large': [2240, 2317], '80-kDa': [2241], 'catalytic': [2242], 'smaller': [2246], '28-kDa': [2247, 2251], 'subunit.': [2249], 'identical': [2254], 'μ-': [2256, 2320], 'required': [2260, 4052, 4344], 'vivo,': [2265, 2627], 'encoded': [2268], '(23Arthur': [2273, 2329], 'Hegadorn': [2277, 2333], 'Williams': [2279, 2335], '2000;': [2286, 2342], '4474-4481Crossref': [2288, 2344], '(295)': [2291, 2347], 'Murine': [2294], 'mice': [2299], 'determine': [2303, 2489, 2653, 3665], 'whether': [2304, 2495, 2654], 'plays': [2306], 'role': [2308, 3667, 3769], '(expression': [2314], 'subunits': [2318], 'm-calpain': [2322], 'not': [2324, 2861, 2929, 2946, 3021, 3601, 3630, 3710, 3970, 4116, 4299, 4343], 'changed': [2325], 'these': [2327, 2386, 2967, 3818, 4150], 'Scholar)).': [2349], 'FLAG-tagged': [2353], 'codon-optimized': [2354], '(pIRES-Neo2-eE7)': [2357], 'murine': [2362, 2458], 'fibroblasts,': [2364], 'levels': [2367, 2384, 2420, 2424, 2453, 2597, 2690, 2854, 3373, 3408, 3588, 3690, 3751, 3795, 3944, 4201], 'Increasing': [2373], 'amounts': [2374], 'had': [2378, 3444], 'little': [2379], 'effect': [2380], 'calpain-defective': [2387], '(Fig.': [2389, 2413, 2426, 2543, 2573, 2794, 2827, 2866, 2890, 3158, 3183, 3358, 3397, 3409, 3433, 3589, 3610, 3634, 3716, 3761, 3796, 3926, 3945, 3961, 3978, 4003, 4153, 4305], '1A,': [2390, 2414, 2427], 'top': [2391, 2428, 2829, 2868, 3190, 3411, 3798], 'panel,': [2392, 2429, 2830, 2869, 2893, 3412, 3436, 3799], 'compare': [2393, 2430, 3800], 'lane': [2394, 2431, 2465, 2545, 2575, 3160, 3185, 3399, 3413, 3437, 3718, 3763, 4133], '1': [2395, 2797], 'lanes': [2397, 2416, 2434, 2796, 2831, 2870, 2894, 3593, 3614, 3637, 3801], '2–5).': [2398], 'contrast,': [2400, 3402], 'when': [2401, 2595, 3972], 'restored': [2405, 3695], 'co-transfection': [2407], 'anti-CAPN4,': [2415], '6–10),': [2417], 'dropped': [2421], '6': [2432, 2462], '7–10).': [2435], 'These': [2436, 3446], 'experiments': [2437], '(the': [2451], 'lower': [2452, 2537, 2821], '(lane': [2461], 'compared': [2463, 2672], '1)': [2466], 'supports': [2468], 'view': [2470], 'degrading': [2476], 'absence': [2480, 2516, 2607, 3321, 3580, 4204], 'E73).': [2482], 'Vitro—To': [2488], 'free': [2493], 'system': [2494], 'enhances': [2497, 3556, 3838], 'Rb,': [2501, 2693, 3144, 3834, 3911], 'GST-eE7.': [2518], 'resulted': [2525, 2566, 2847, 3117, 3789, 3957], 'generation': [2528, 3084], 'faster': [2531], 'migrating': [2532], 'species': [2534, 2586, 2623, 2658, 2667, 2675, 2697, 2723, 2767, 2859, 2865, 2883, 2905, 2926, 2936, 2944, 2983, 3019, 3089, 3178, 3697, 4108, 4127], 'molecular': [2538, 2822, 3014], 'mass': [2539, 2823, 3200], '≈95': [2541, 2825, 2907, 3700], 'kDa': [2542, 2826, 2908, 3182, 3701], '1B,': [2544, 2574], '2,': [2546, 3161], 'Cleaved': [2547, 2645, 3187, 3468], 'Rb),': [2548], 'could': [2550, 2724, 2879], 'distinguished': [2552], '110-kDa': [2555, 2721, 2863, 2934], '(Rb1–928).': [2558], 'almost': [2568, 3227], 'complete': [2569], 'loss': [2570, 4030], '3),': [2576, 3414, 3438], 'enhanced': [2580], 'activity.': [2582, 2618, 3993], '≈95-kDa': [2584, 2622, 2857, 2881, 2924, 2942, 3087], 'further': [2589, 2986], 'degraded,': [2590], 'seen': [2594, 3726, 4242], 'increasing': [2596, 2616], 'added': [2601, 3677, 3781], 'such': [2603, 4261], 'reactions': [2604], 'eE7,3': [2609], 'again': [2612, 3653, 3983], 'consistent': [2613, 4039], 'However,': [2619, 3966, 4289], 'only': [2620, 2636], 'other': [2631], 'products': [2634], 'under': [2638], 'conditions.3': [2641], 'C-terminally': [2644], 'Lines': [2649], 'Proteasomal': [2651, 3464], 'Degradation—To': [2652], 'cleaved': [2656, 3174], 'might': [2659, 3090, 3747, 4121], 'present': [2661], 'cells,': [2664, 2735, 3369, 3576], 'cells.': [2679, 3684], 'Fully': [2680], 'confluent,': [2681], 'largely': [2682, 3756], 'non-replicating': [2683], 'maximize': [2688], 'targeted': [2698, 4268], 'As': [2718, 3379, 3595, 3746, 3931], 'expected,': [2719, 3596, 3749, 3932], 'clearly': [2726], 'Jurkat': [2730], '(non-HPV-transformed)': [2732], 'S1a': [2734], 'SerpinB2-expressing': [2737], 'line': [2740, 2878], 'silenced': [2746], 'This': [2765, 3053, 3094, 3223, 3286, 3307, 3639, 3720, 3788, 4019, 4036, 4334], 'G3245': [2773, 2812], '(that': [2775, 2787], 'toward': [2777], 'N': [2779], 'terminus': [2780, 2791, 3142], 'Rb)': [2782, 2793], 'C': [2790, 2916, 3141], '1C,': [2795, 2828, 2867, 2891, 4132], '2).': [2799, 3400], 'When': [2800, 3616], '(HPV-18-transformed)': [2802], '(HPV-16-transformed)': [2805], 'probed': [2809], 'antibody,': [2813], 'bands': [2814], '5).': [2834], 'Incubation': [2835], 'increase': [2851, 3007], '6).': [2873, 2897, 4134], 'Importantly,': [2874, 3423, 3994], 'neither': [2876], 'bottom': [2892], 'Thus,': [2898], 'can': [2909], 'missing': [2914], 'terminus.': [2917], 'Furthermore,': [2918], 'inhibited': [2920, 4139], 'did': [2928, 4115, 4298], 'restore': [2930], '(migration': [2937], '110-': [2940], 'affected': [2947], 'if': [2948], 'samples': [2950], 'phosphatases;': [2955], 'supplemental': [2956], 'Fig.': [2957, 3124, 3218, 3284, 3305, 3728, 4131], 'S1A).': [2958], 'Taken': [2959, 3816], 'together': [2960], 'Figs.': [2962], '1,': [2963], 'B,': [2966], 'data': [2968, 3447, 3736, 3819], 'suggest': [2969, 3737, 3820], 'promotes': [2972, 3545, 3643, 3740, 3830], 'calpain-cleaved': [2981], 'degraded': [2987], 'proteasome.': [2990, 3815], 'Treatment': [2991], 'MG-132': [3000, 3061, 3115], 'levels,': [3010], 'although': [3011], 'weight': [3015, 3203], 'observed': [3022], '(11Wang': [3023, 4087], 'due': [3056], 'fact': [3059], '(24Mailhes': [3065], 'J.B.': [3066], 'Hilliard': [3067], 'Lowery': [3069], 'London': [3071], 'Chromosome.': [3074], '1:': [3076], '2-8Crossref': [3077], '(34)': [3080], 'so': [3083], 'inhibited.': [3093], 'contention': [3095], 'supported': [3097], 'should': [3113, 3896], 'mimic': [3114], 'treatment,': [3116], 'restoration': [3119, 3791], '(supplemental': [3123, 3217, 3283, 3304], 'S1B).': [3125], 'Mapping': [3126], 'C-terminal': [3129, 3146, 3442, 4047], 'Site': [3131], 'Rb—To': [3133], 'identify': [3134], 'postulated': [3136], 'calpain-cleavage': [3137], 'site': [3138, 3210, 3292, 3308, 3316], 'within': [3139], 'fragment': [3147], '(Rb768–928)': [3150], '1D,': [3159, 3184], 'GST-Rb768–928).': [3162, 3188], 'With': [3163], 'GST-eE7,': [3169], '55-kDa': [3171], 'running': [3179], '≈30': [3181], '3,': [3186], 'band': [3191], 'excised': [3193], 'gel': [3196], 'spectrometry.': [3201], 'Molecular': [3202], 'suggested': [3205, 3479, 3640], 'located': [3212], 'around': [3213], 'Rb809': [3214], 'Rb816': [3216], 'S2,': [3219], 'B).': [3222], 'contains': [3225, 4251], 'perfect': [3228], 'match': [3229, 3287], 'preferred': [3232], 'P3,': [3233], 'P2,': [3234], 'P1,': [3235], 'P1′,': [3236], 'P2′,': [3237], 'P3′': [3239], 'amino': [3240], 'acid': [3241], 'residues': [3242], 'Tompa': [3248], 'et': [3249, 4085, 4312], 'al.': [3250, 4086, 4313], '(25Tompa': [3251], 'Buzder-Lantos': [3253], 'Tantos': [3255], 'Farkas': [3257], 'Szilagyi': [3259], 'Banoczi': [3261], 'Z.': [3262], 'Hudecz': [3263], 'F.': [3264], 'Friedrich': [3265], '279:': [3271], '20775-20785Abstract': [3272], '(261)': [3280], 'S2C).': [3285], 'lies': [3293], 'between': [3294], 'P1': [3295, 3338, 3453, 3551], 'Rb810': [3297, 3456, 3552, 3659, 3989], '(lysine)': [3298], 'P1′': [3300], 'Rb811': [3302], '(serine)': [3303], 'S2D).': [3306], 'identified': [3311], 'E7.3': [3323], 'Requires': [3328], 'Amino': [3330, 3470], 'Acid': [3331, 3471], '810—To': [3332], 'confirm': [3333], 'importance': [3335, 3656, 3986], '(Rb810)': [3340], 'E7/calpain-mediated': [3342], 'lysine': [3347], 'position': [3350, 3705], 'replaced': [3352], 'alanine': [3354], 'generate': [3356], '2A).': [3359], 'blot.': [3378], 'expected': [3380], 'given': [3381], 'endogenous': [3385, 3924], 'level': [3391], 'low': [3393], '2B,': [3398, 3410, 3434], 'indicating': [3415, 3439, 3805, 4006], 'resistant': [3419], 'anti-Rb': [3431, 3591, 3608, 3612], 'middle': [3435], 'occurred.': [3445], 'indicate': [3448], 'renders': [3457], '810': [3472], 'Enhanced': [3474], 'E7—Numerous': [3476], 'studies': [3477], 'reduces': [3482], 'stability': [3484], 'enhancing': [3486], 'We,': [3535], 'sought': [3537], 'test': [3539, 3766], 'hypothesis': [3541], 'RbK810A,': [3568, 3599, 3631, 3963, 3980], 'Rb-defective': [3574], 'SAOS-2': [3575, 3683, 3912, 3954, 4151], 'they': [3583], 'comparable': [3587], '2C,': [3590, 3611, 3635, 3717, 3762, 3797], 'G3245,': [3592], '2–4).': [3594, 3615], 'recognized': [3604, 3711], 'C15,': [3613], 'co-expressed': [3619, 3975], 'three': [3622], 'different': [3623], 'species,': [3625], 'undetectable': [3633], 'anti-Rb,': [3636], '6–8).': [3638], 'illustrated': [3654], 'To': [3664, 3765], 'process,': [3674], 'Rb-expressing': [3682], 'restored,': [3692], 'migrated': [3698], '(in': [3702], 'same': [3704], 'Rb1–810)': [3707], '10).': [3719], 'similar': [3722], 'result': [3725], '1C': [3729], '(lanes': [3730], '6),': [3733], 'eE7/E7': [3739], 'unaffected': [3757], '11).': [3764], 'directly': [3767], 'eE7.': [3787], '8': [3802], '12),': [3804], 'dependent': [3812], 'together,': [3817], 'process.': [3827], 'Inactive': [3850], 'Mediating': [3852], 'Growth': [3853], 'Arrest—Helt': [3854], 'proposed': [3870], 'stage': [3874, 3890], 'release': [3882], 'If': [3887], 'cleavage,': [3893], 'effectively': [3902], 'growth': [3905, 3915, 4017], 'arrest.': [3906, 4018], 'undergo': [3914], 'adopt': [3917], 'flat': [3919], 'phenotype,': [3921], 'SA-β-galactosidase': [3925, 3939, 3959, 4001, 4234], '2D,': [3927, 3946, 3962, 3979, 4004, 4154, 4306], 'black': [3929, 3964], 'bar).': [3930, 3949, 3965], 'co-expression': [3933], 'Rb-mediated': [3938], 'back': [3941], 'white': [3948, 3981], 'Expression': [3950], 'induction': [3960, 3968, 4148], 'lost': [3971], 'bar),': [3982], 'illustrating': [3984], 'induce': [4000], 'Rb1–810),': [4005], 'E7-promoted': [4023], 'recent': [4042], 'showing': [4044], 'affinity': [4055], '(26Rubin': [4061], 'Gall': [4063], 'A.L.': [4064], 'Zheng': [4065], 'Pavletich': [4067], 'N.P.': [4068], '123:': [4071], '1093-1106Abstract': [4072], '(186)': [4080], 'Interestingly,': [4083], 'Wang': [4084], 'reported': [4104], 'accumulating': [4109], 'lactacystin-treated': [4111], 'E2F,': [4118], 'one': [4120], 'now': [4122], 'propose': [4123], 'SA': [4146], '+': [4156, 4238], 'SerpinB2).': [4157], 'Similar': [4158], 'K810A': [4161], 'mutant,': [4162], 'Because': [4191], 'turnover': [4195], 'increases': [4199], 'percentage': [4233], 'exceeds': [4240], 'Rb1–928.': [4244], 'N-terminal': [4246, 4294], '(Rb8–62)': [4250], 'scoring': [4254], 'PEST': [4255, 4340], 'sequence': [4256, 4341], '(+14.93': [4257], 'PESTfind),': [4259], 'sequences': [4262], '(27Rechsteiner': [4271], 'Rogers': [4273], 'S.W.': [4274], 'Trends': [4275], '21:': [4279], '267-271Abstract': [4280], '(1405)': [4286], 'removal': [4291], 'diminish': [4300], 'Rb394–928)': [4307], 'agreement': [4309], 'Gonzalez': [4311], 'E7-enhanced': [4346], 'Able': [4353], 'Repress': [4355], 'Transcription': [4356], 'URR—We': [4360], 'polycistronic': [4375], 'mRNA': [4377], 'integrated': [4380], 'URR': [4382], 'agr': [4402]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2011463325', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-14T13:24:06.518625', 'created_date': '2016-06-24'}
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