Spontaneous Thermal Motion of the GABAA Receptor M2 Channel-lining Segments

Name: Work Video:
Duration: 3 min 30 s
Amal Kanti Bera; Myles H. Akabas
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1757, 1761, 1764, 1779, 1840, 1861, 1874, 1917, 1922, 1934, 1939, 2065, 2088, 2094, 2100, 2121, 2142, 2160, 2172, 2194, 2197, 2203, 2265, 2534, 2613, 2645, 2651, 2695, 2701, 2721, 2727, 2754, 2784, 2794, 2804, 2815, 2825, 2845, 2873, 2905, 2913, 2944, 2961, 2973, 2984, 2990, 2994, 2999, 3009, 3026, 3034, 3051, 3056, 3068, 3075, 3080, 3086, 3092, 3113, 3123, 3129, 3136, 3170, 3179, 3196, 3203, 3215, 3224, 3234, 3239, 3247, 3302, 3310, 3321, 3333, 3336, 3352, 3373, 3389, 3407, 3424, 3432, 3435, 3458, 3461, 3481, 3488, 3501, 3504, 3523, 3569, 3572, 3576, 3585, 3601, 3610, 3634, 3664, 3706, 3752, 3763, 3784, 3787, 3793, 3797, 3816, 3829, 3845, 3876, 3911, 3924, 3940, 3963, 3971, 3976, 4022, 4038, 4076, 4093, 4111, 4123, 4135, 4141, 4156, 4163, 4166, 4172, 4186, 4190, 4193, 4200, 4231, 4266, 4285, 4292, 4305, 4309, 4320, 4323, 4337, 4345, 4406, 4415, 4423, 4426, 4429, 4432, 4435, 4444, 4451, 4454, 4457, 4507, 4513, 4524, 4531, 4535, 4573, 4576, 4596, 4601, 4604, 4618, 4647, 4655, 4661, 4669, 4677, 4683, 4689, 4700, 4708, 4713, 4717, 4722, 4743, 4750, 4756, 4763, 4771, 4779, 4783, 4787, 4792, 4813, 4817, 4825, 4869, 4878, 4883, 4900, 4924, 4944, 4957, 4965, 4985, 4991, 5004, 5020, 5035, 5048, 5060, 5069, 5073, 5076, 5092, 5104, 5125, 5151, 5154, 5158, 5176, 5187, 5204, 5283, 5311, 5317, 5345, 5350, 5358, 5375, 5383, 5389, 5403, 5451, 5455, 5459, 5462, 5528, 5539, 5543, 5556, 5560, 5563, 5598, 5610, 5616, 5621, 5626, 5629, 5634, 5637, 5641, 5652, 5655, 5673, 5687, 5703, 5709, 5731, 5744, 5748, 5754, 5759, 5766, 5769, 5801, 5808, 5817, 5826, 5830, 5846, 5855, 5864, 5867, 5887, 5903, 5906, 5912, 5919, 5927, 5980, 5996, 5999, 6004, 6013, 6017, 6021, 6024, 6032, 6036, 6042, 6053, 6062, 6067, 6079, 6084, 6087, 6099, 6128, 6132, 6134, 6145, 6148, 6158, 6164, 6173, 6179, 6183, 6191, 6203, 6218, 6226, 6231, 6283, 6292, 6298, 6310, 6353, 6357, 6391, 6410, 6415, 6425, 6449, 6453, 6462, 6465, 6475, 6486, 6490, 6494, 6499, 6504, 6531, 6538], 'five': [16, 275, 665, 953], 'channel-lining,': [17, 276], 'M2': [18, 22, 40, 229, 257, 277, 281, 299, 488, 516, 944, 979, 997, 1024, 1068, 1239, 1417, 1427, 1570, 1616, 1704, 4338, 4436, 4525, 4767, 4773, 5074, 5105, 5169, 5177, 5346, 5376, 5456, 5529, 5631, 5656, 5704, 5723, 5741, 5756, 5818, 5913, 6037, 6180, 6412, 6466, 6495], 'transmembrane': [19, 278, 698, 945], 'segments.': [20, 258, 279, 517, 1571], "segment's": [23, 41, 282, 300], 'extracellular': [24, 240, 283, 499, 680, 993, 4532, 5070, 5525, 6491], 'half': [25, 284], 'is': [26, 60, 71, 285, 319, 330, 526, 722, 843, 939, 960, 1015, 1069, 1831, 1856, 1903, 1926, 2072, 2814, 2824, 2844, 3067, 3074, 3079, 3085, 3789, 3921, 3943, 4004, 4059, 4160, 4464, 4664, 4736, 4753, 4819, 4828, 4892, 4914, 5088, 5326, 5465, 5693, 5716, 5851, 5890, 5977, 6039, 6124, 6215, 6289, 6306, 6430, 6483], 'loosely': [27, 286, 1000], 'packed': [28, 287, 1313, 5468, 5822], 'undergoes': [30, 289, 5470], 'significant': [31, 290, 3541, 3655, 4439, 5108, 5647], 'thermal': [32, 291, 1700, 1937, 4441, 4517, 5648, 6176, 6481], 'motion.': [33, 292, 1710, 5649], 'To': [34, 293, 2692, 3566, 4169], 'characterize': [35, 294], 'extent': [37, 201, 296, 460, 2646, 2789, 2985, 4445, 4514, 4761, 5856, 5907, 6174, 6479], 'motion,': [42, 301, 4442, 4458, 5110], 'we': [43, 302, 1507, 1690, 2061, 2091, 2725, 3588, 3624, 4184, 4198, 4510, 5111, 5307, 5445, 5923, 6209, 6278, 6325], 'used': [44, 303, 534, 1692, 1768, 1951, 2854, 3252, 4929], 'disulfide': [45, 128, 304, 387, 1177, 1470, 1510, 1531, 1693, 1722, 1808, 1827, 1836, 1848, 1866, 1870, 1911, 2131, 2150, 2181, 2209, 2219, 2656, 2684, 2708, 2747, 2799, 3221, 3329, 3451, 3464, 3494, 3513, 3620, 3627, 3700, 3735, 3757, 3775, 3804, 3872, 3897, 3928, 3956, 3984, 4107, 4124, 4152, 4310, 4324, 4553, 4559, 4580, 4624, 4634, 4678, 4684, 4733, 4811, 4947, 5116, 5155, 5599, 5981, 6025, 6068, 6088, 6207, 6288, 6316, 6330, 6369, 6399], 'trapping': [46, 305, 1178, 1408, 1694, 1948, 6346], 'experiments': [47, 221, 306, 480, 1409, 1695, 2060, 2086, 2857, 4556, 6407], 'between': [48, 99, 110, 119, 131, 307, 358, 369, 378, 390, 1016, 1037, 1296, 1410, 1473, 1523, 1747, 1959, 2154, 2615, 2977, 3223, 3233, 3344, 3518, 3705, 3760, 3880, 3900, 3931, 3945, 3987, 4018, 4072, 4110, 4519, 4563, 4600, 4629, 4641, 4646, 4658, 4692, 4721, 4746, 4882, 4910, 5120, 5562, 5601, 5664, 5800, 5860, 5911, 5985, 6070, 6153, 6217, 6225, 6302, 6333, 6414], 'pairs': [49, 308, 3914, 6155, 6348], 'engineered': [51, 310, 1411, 2722, 3235, 3334, 3505, 3586, 4520, 6335, 6358], 'cysteines.': [52, 311], 'In': [53, 163, 312, 422, 985, 1055, 1285, 1466, 1501, 1629, 4428, 4506, 4611, 4674, 4712, 4809, 4868, 5162, 5835, 6003, 6065, 6276, 6402], 'α1β1γ2S': [54, 313], 'receptors': [55, 314, 546, 585, 707, 1040, 1097, 1468, 2070, 3298], 'single': [57, 316, 2074, 3204, 3863], 'γ': [58, 317, 715, 731, 6232], 'subunit': [59, 76, 211, 318, 335, 470, 674, 720, 732, 1238, 2076, 2090, 2102, 2378, 3139, 6229, 6233], 'flanked': [61, 320], 'by': [62, 124, 181, 321, 383, 440, 529, 661, 709, 942, 962, 969, 1028, 1845, 2191, 2304, 2587, 2592, 2650, 2716, 2769, 2803, 2887, 2989, 3029, 3112, 3273, 3286, 3402, 3469, 3473, 3553, 3575, 3584, 3639, 3675, 3686, 3814, 3844, 3975, 4179, 4617, 4681, 4933, 4956, 4998, 5011], 'an': [63, 322, 676, 949, 963, 1729, 1774, 4988, 4999, 5012, 5399, 5690, 5797], 'α': [64, 210, 323, 469, 724, 1876, 1924, 2089, 2198, 4826, 4879, 4989, 6228], 'β': [66, 325, 727], 'subunit.': [67, 326, 5161], 'γ2M2-14′': [69, 328], 'position': [70, 329, 4663, 5046, 5128, 5712], 'located': [72, 331], 'in': [73, 143, 178, 224, 235, 332, 402, 437, 483, 494, 521, 795, 1022, 1131, 1241, 1436, 1513, 1520, 1526, 1753, 1760, 1820, 1839, 1933, 1961, 2068, 2087, 2099, 2141, 2262, 2280, 2306, 2319, 2342, 2384, 2401, 2423, 2470, 2477, 2509, 2837, 3102, 3253, 3397, 3527, 3543, 3556, 3633, 3740, 3835, 3875, 3962, 4021, 4075, 4099, 4140, 4155, 4162, 4192, 4228, 4336, 4341, 4450, 4699, 4707, 4730, 4755, 4786, 4964, 5047, 5052, 5059, 5129, 5183, 5190, 5201, 5458, 5609, 5615, 5625, 5651, 5681, 5686, 5708, 5736, 5743, 5753, 5758, 5902, 5926, 5994, 6016, 6041, 6052, 6078, 6098, 6127, 6143, 6163, 6182, 6282, 6291, 6356, 6390, 6424, 6498, 6536], 'α-γ': [75, 334, 2101], 'interface.': [77, 336, 2077], 'γ213′': [78, 90, 337, 349], 'faces': [79, 338], 'lumen.': [82, 341], 'We': [83, 342, 1559, 1767, 2119, 2146, 2200, 3210, 3316, 3442, 3696, 4147, 4727, 4738, 6541], 'expressed': [84, 343, 2494, 3526], 'either': [85, 344, 3245, 3332, 3719, 4572, 5182], 'γ214′': [87, 218, 346, 477, 2128, 2155, 2173, 4567, 4659, 4911, 5087, 5359, 5602, 5986], 'or': [88, 347, 2672, 2718, 2922, 3232, 3257, 3324, 3335, 3721, 4165, 4460, 4462, 4575, 5189, 6294, 6389], 'cysteine': [91, 96, 350, 355, 1141, 1231, 1287, 2083, 2227, 3989, 6336], 'substitution': [92, 97, 351, 356, 2228, 3304], 'mutants': [93, 98, 352, 357, 2229, 3141, 3172, 3207, 3218, 3251, 3305, 3327, 3356, 3449, 3524, 4008, 4063], 'with': [94, 139, 153, 158, 191, 216, 353, 398, 412, 417, 450, 475, 695, 1305, 1314, 1853, 2133, 2183, 2211, 2221, 2338, 2350, 2368, 2518, 2545, 2662, 2689, 2740, 2921, 2935, 2955, 3055, 3150, 3259, 3299, 3331, 3357, 3475, 3484, 3622, 3771, 3861, 3923, 3970, 4127, 4242, 4668, 4705, 4886, 5030, 5086, 5103, 5796, 5807, 5823, 6318, 6343, 6362, 6386, 6485], 'α1': [95, 354, 3138, 3205, 3216, 3262, 3323, 3354, 3765], '12′': [100, 359], '16′': [102, 361, 4994], 'wild-type': [104, 363, 3151], 'β1.': [105, 364], 'Disulfide': [106, 135, 365, 394, 1407, 1947, 2621, 3341, 3607, 3748, 6345], 'bonds': [107, 366, 1471, 2132, 2151, 2182, 2210, 2800, 3222, 3330, 3621, 3736, 4125, 4560, 4679, 5600, 6317], 'formed': [108, 367, 660, 708, 968, 1472, 2180, 2217, 2655, 2798, 3219, 3328, 3454, 3516, 3704, 3774, 4126, 4561, 4628, 4680, 4691, 5608, 6074, 6315], 'spontaneously': [109, 368, 2654, 2797, 3455, 3517, 3618, 4562, 5659], 'γ214′C': [111, 132, 140, 370, 391, 399, 3358, 3761, 3881, 3901, 3972, 4602, 4630, 6303, 6319], 'both': [113, 372, 1574, 1962, 2681, 2719, 3883, 5995, 6144, 6438], 'α115′C': [114, 373, 3884], 'α116′C': [116, 375, 3886], 'also': [118, 377, 1612, 2201, 3266, 3515, 3960, 4627, 6093, 6568], 'γ213′C': [120, 379, 2206, 2216, 3256, 3519, 4115, 6204], 'α113′C.': [122, 134, 381, 393, 2214, 2222, 4632], 'Oxidation': [123, 382, 3285], 'copper': [125, 384, 834, 1769, 4621], 'phenanthroline': [126, 385, 835, 1770], 'induced': [127, 386, 3028, 3632, 3739], 'bond': [129, 136, 388, 395, 1511, 1532, 1723, 1809, 1828, 1837, 1849, 1871, 1912, 2220, 2685, 2709, 3452, 3465, 3495, 3514, 3628, 3701, 3758, 3805, 3873, 3898, 3929, 3957, 3985, 4108, 4153, 4311, 4325, 4581, 4625, 4635, 4685, 4690, 4734, 4948, 5117, 5156, 5982, 6026, 6069, 6089, 6331, 6370, 6400], 'formation': [130, 137, 389, 396, 1512, 1533, 1780, 1810, 1838, 1850, 1855, 1908, 2710, 3496, 3629, 3759, 3806, 3874, 3899, 3930, 3958, 3986, 4109, 4154, 4326, 4582, 4636, 4686, 4735, 5983, 6027, 6090, 6332, 6371], 'rates': [138, 397, 4316, 4583, 5984, 6028, 6136, 6159, 6397], 'were': [141, 400, 1823, 2230, 2291, 2302, 2317, 2362, 2421, 2475, 2504, 2556, 2585, 2607, 2660, 2677, 3004, 3041, 3100, 3164, 3174, 3271, 3525, 3780, 3812, 3842, 3887, 3959, 3973, 4176, 4584, 4609, 5820, 5992], 'similar': [142, 251, 401, 510, 845, 2839, 3430, 3559, 3712, 4585, 5671, 5993, 6040, 6142], 'presence': [145, 404, 1243, 1441, 1515, 1727, 3964, 3977, 4023, 4077, 4142, 4157, 4619, 4701, 4714, 4757, 6000, 6006, 6080, 6100, 6149, 6165, 6284], 'absence': [147, 406, 1438, 2143, 3877, 4025, 4079, 4709, 5611, 5688, 5997, 6146], 'GABA,': [149, 408, 1517, 6151, 6286], 'although': [150, 409, 1643, 6172], 'rate': [152, 411, 3778, 4637, 4687, 6091], 'α113′C': [154, 413, 3521, 3903, 6206], 'was': [155, 414, 2168, 2260, 2278, 2403, 2468, 2531, 2619, 2632, 2638, 2705, 2767, 2780, 2801, 2835, 2853, 2885, 2909, 2926, 2941, 2947, 3022, 3400, 3491, 3551, 3672, 3684, 3807, 3904, 4118, 4239, 4626, 4638, 4696, 4961, 6092], 'slower': [156, 415, 3918, 4119, 4640], 'than': [157, 416, 2455, 2912, 3167, 3908, 4120, 4304, 4645, 4666, 5091, 5324, 5402], 'other': [160, 419, 1644, 3171, 3912, 4648, 4670, 5401, 5839, 6154], 'two': [161, 209, 420, 468, 723, 726, 1923, 2671, 3225, 3248, 3371, 3447, 3913, 4588, 4643, 4649, 4671, 5812, 6196], 'positions.': [162, 421, 4673], 'a': [164, 423, 690, 1029, 1118, 1247, 1566, 1625, 1714, 1721, 1858, 1869, 1910, 2073, 2124, 2218, 2372, 2483, 2510, 2522, 2537, 2550, 2561, 2568, 2683, 2730, 2746, 2758, 2770, 2838, 2888, 2896, 2932, 2937, 2968, 3044, 3106, 3230, 3274, 3287, 3380, 3403, 3428, 3450, 3540, 3557, 3654, 3676, 3687, 3699, 3852, 3862, 4100, 4206, 4243, 4298, 4411, 4564, 4569, 4612, 4623, 4810, 5115, 5334, 5337, 5396, 5407, 5549, 5661, 5682, 5717, 5849, 6381], 'homology': [165, 424], 'model': [166, 425], 'based': [167, 426], 'on': [168, 427, 1126, 1573, 1725, 1733, 1742, 2079, 2159, 2193, 2983, 3195, 3309, 3600, 3726, 3828, 4297, 4523, 4923, 5040, 5167, 6571], 'acetylcholine': [170, 429, 578, 829], 'structure,': [172, 431, 991], 'αM2': [173, 197, 432, 456, 2161, 2167, 4672, 5021, 5036], 'would': [174, 198, 433, 457, 2164, 5033, 5080, 5096, 5348, 5554, 5706], 'need': [175, 434], 'to': [176, 183, 206, 435, 442, 465, 846, 856, 1010, 1034, 1624, 1696, 1719, 1772, 1817, 1825, 1864, 1872, 1880, 1905, 1943, 1952, 2129, 2138, 2171, 2207, 2213, 2336, 2482, 2533, 2600, 2609, 2643, 2699, 2707, 2713, 2752, 2776, 2782, 2793, 2828, 3006, 3013, 3025, 3050, 3294, 3427, 3431, 3457, 3479, 3493, 3507, 3560, 3581, 3649, 3716, 3803, 4205, 4230, 4235, 4343, 4676, 4770, 4935, 5038, 5171, 5315, 5328, 5356, 5672, 5828, 5854, 6060, 6205, 6360, 6367, 6372, 6394, 6436, 6448, 6529], 'rotate': [177, 436, 1619, 5039, 5180], 'opposite': [179, 438, 5061], 'directions': [180, 439], '∼80°': [182, 441, 5051], 'bring': [184, 207, 443, 466, 5081, 5097, 5316, 5357], 'α113′': [185, 444, 4662, 4913, 5098], 'α115′': [187, 446, 4574, 4605, 5082], 'into': [188, 213, 447, 472, 4422, 5027, 5083, 5099, 5173, 5366, 5730], 'close': [189, 214, 448, 473, 5028, 5084, 5100, 5174, 5367], 'proximity': [190, 215, 449, 474, 1957, 5029, 5085, 5368], 'γ214′.': [192, 451], 'Alternatively,': [193, 452, 5336], 'motion': [195, 204, 234, 454, 463, 493, 1130, 1431, 1701, 1938, 4448, 4518, 4764, 5018, 5332, 5343, 5354, 5373, 5408, 5663, 5674, 5738, 5752, 5921, 6034, 6177, 6423, 6434, 6482], 'reduce': [199, 458, 2682, 2745, 5349], 'necessary': [205, 464, 5355, 5891], 'these': [208, 467, 2059, 3182, 3446, 3741, 4587, 4642, 5025, 6195, 6235, 6334, 6404], 'residues': [212, 471, 1094, 1254, 1413, 1419, 1475, 1482, 1525, 1718, 1960, 2140, 2187, 3228, 3237, 4134, 4522, 4644, 5026, 5122, 6139, 6157, 6238, 6313], 'position.': [219, 478, 2174, 4578], 'These': [220, 479, 4555, 6443], 'demonstrate': [222, 481, 2177, 2777, 3007], 'that': [223, 482, 575, 683, 852, 947, 976, 1306, 1425, 1561, 1614, 1637, 1812, 1907, 1916, 1932, 2067, 2093, 2148, 2166, 2178, 2188, 2694, 2778, 2842, 3008, 3212, 3318, 3444, 3487, 3561, 3571, 3615, 3698, 3733, 3909, 3939, 4121, 4171, 4558, 4595, 4654, 4667, 4706, 4742, 4823, 4951, 5079, 5095, 5114, 5310, 5450, 5675, 5700, 5845, 5861, 5889, 5901, 5922, 5979, 6031, 6171, 6213, 6314, 6351, 6378, 6409, 6452, 6459], 'closed': [226, 485, 840, 1123, 4416, 5617, 5653, 5666, 5760, 5802, 5904, 6043, 6184, 6426], 'state': [227, 486, 841, 4417, 4732, 5619, 5628, 5654, 5669, 5711, 5733, 5746, 5761, 5805, 5905, 6055], 'segments': [230, 489, 699, 946, 975, 980, 998, 1428, 1617, 1705, 4340, 4437, 4526, 5106, 5170, 5178, 5530, 5632, 5657, 5705, 5724, 5742, 5757, 5819, 5914, 6038, 6181, 6413, 6467, 6496], 'undergo': [231, 490, 1429, 4438, 4719, 6420, 6455], 'continuous': [232, 491, 6421], 'spontaneous': [233, 492, 1538, 1699, 3220, 3927, 4440, 4516, 5714, 6422], 'region': [237, 496, 1005, 1307, 1762, 4430, 5558, 5850, 5862, 6130], 'near': [238, 497], 'end': [241, 500, 1066, 1292, 1356, 4533, 5453, 5526, 5545, 5639], 'gate.': [245, 504, 6540], 'Opening': [246, 505], 'gate': [248, 507, 4347, 4538, 5644], 'may': [249, 508, 1618, 5531, 5762, 5899, 6029, 6056, 6188, 6198, 6445, 6460], 'involve': [250, 509, 1565, 6437, 6461], 'but': [252, 511, 1518, 1623, 2743, 3173, 3683, 3791, 4419, 4443, 5680, 5727], 'concerted': [253, 512], 'Fast': [518], 'inhibitory': [519], 'neurotransmission': [520], 'central': [523, 670, 5384], 'nervous': [524], 'system': [525, 1030, 1057], 'largely': [527, 940], 'mediated': [528], 'GABAA': [531, 706, 838, 1096, 4329, 5896], '3The': [532], 'abbreviations': [533], 'are:': [535], 'GABAAγ-aminobutyric': [536], 'AAChacetylcholineCFFRCa2+-free': [539], 'frog': [540, 831, 2426], 'Ringers': [541, 832], 'solutionCu:phencopper': [542], 'phenanthrolineDTTdithiothreitol.': [543], 'glycine': [545], '(1Rabow': [547], 'L.E.': [548], 'Russek': [549], 'S.J.': [550], 'Farb': [551], 'D.H.': [552], 'Synapse.': [553], '1995;': [554, 1604, 2010], '21:': [555, 881], '189-274Crossref': [556], 'PubMed': [557, 594, 609, 634, 654, 746, 762, 782, 820, 869, 883, 903, 918, 931, 1050, 1111, 1156, 1174, 1192, 1225, 1280, 1327, 1349, 1377, 1402, 1461, 1496, 1554, 1596, 1607, 1661, 1684, 1802, 1897, 1978, 1996, 2013, 2032, 2053, 2114, 2254, 4358, 4383, 4396, 4479, 4501, 4547, 4804, 4848, 4863, 4979, 5145, 5218, 5238, 5255, 5277, 5301, 5426, 5439, 5493, 5519, 5578, 5591, 5790, 5881, 5949, 5971, 6116, 6249, 6271, 6520], 'Scopus': [558, 595, 610, 635, 655, 783, 821, 870, 904, 919, 932, 1051, 1112, 1157, 1193, 1226, 1281, 1328, 1350, 1378, 1403, 1462, 1497, 1555, 1597, 1608, 1662, 1685, 1803, 1898, 1979, 1997, 2014, 2033, 2054, 2115, 2255, 4359, 4384, 4397, 4480, 4502, 4548, 4805, 4849, 4864, 4980, 5146, 5219, 5239, 5256, 5278, 5302, 5427, 5440, 5494, 5520, 5579, 5592, 5791, 5882, 5950, 5972, 6117, 6250, 6272, 6521], '(458)': [559], 'Google': [560, 597, 612, 637, 657, 747, 763, 785, 823, 872, 884, 906, 921, 934, 1053, 1114, 1159, 1175, 1195, 1228, 1283, 1330, 1352, 1380, 1405, 1464, 1499, 1557, 1599, 1610, 1664, 1687, 1805, 1900, 1981, 1999, 2016, 2035, 2056, 2117, 2257, 4361, 4386, 4399, 4482, 4504, 4550, 4807, 4851, 4866, 4982, 5148, 5221, 5241, 5258, 5280, 5304, 5429, 5442, 5496, 5522, 5581, 5594, 5793, 5884, 5952, 5974, 6119, 6252, 6274, 6523], 'Scholar).': [561, 786, 824, 935, 1054, 1115, 1229, 1284, 1353, 1406, 1465, 1500, 1558, 1688, 1806, 1901, 2057, 2118, 2258, 4400, 4505, 4808, 4867, 4983, 5149, 5305, 5443, 5523, 5595, 5885, 5975, 6120, 6275, 6524], 'receptors,': [563], 'members': [564], 'Cys': [567, 1038, 1412, 1474, 1524, 1717, 1765, 1875, 2125, 2134, 2186, 2723, 3206, 3217, 3227, 3236, 3241, 3250, 3303, 3326, 3338, 3355, 3375, 3506, 3766, 3935, 3949, 4521, 4565, 4570, 4590, 4651, 5121], 'loop': [568, 1039], 'gene': [569], 'superfamily': [570], 'neurotransmitter-gated': [572], 'ion': [573, 937], 'channels': [574, 1632, 4718, 5225, 5245, 5898, 6014], 'includes': [576], 'nicotinic': [577], '(ACh)': [579], 'serotonin': [581], '3': [583, 2538, 2546, 2635, 2929, 2978, 3190, 3421, 4936], '(5-HT3)': [584], '(2Karlin': [586], 'A.': [587, 909, 1151, 1221, 1650, 1669, 1986, 2028, 2040, 2049, 5227, 5290, 5417, 5569, 5779, 5786, 5877, 6516], 'Nat.': [588, 1187, 1491, 1549, 4474, 5140, 6111], 'Rev.': [589], 'Neurosci.': [590, 625, 742, 758, 879, 1188, 1393, 1492, 1550, 4374, 4475, 5141, 6112], '2002;': [591, 606, 895, 5878, 6517], '3:': [592, 1994, 4846], '102-114Crossref': [593], '(781)': [596], 'Scholar,': [598, 613, 638, 748, 764, 873, 885, 907, 922, 1160, 1331, 1381, 1600, 1665, 1982, 2000, 2017, 2036, 4362, 4387, 4483, 4852, 5430, 5497, 5582, 5953, 6253], '3Reeves': [599], 'D.C.': [600, 1266, 1335, 2240, 5479, 5935, 6257], 'Lummis': [601], 'S.C.': [602], 'Mol.': [603, 926, 1106, 1591, 1892, 1973, 4391, 4542, 4799, 4858, 4974, 5213, 5272, 5434, 5586], 'Membr.': [604], 'Biol.': [605, 772, 927, 1107, 1166, 1270, 1339, 1451, 1592, 1893, 1974, 2244, 4392, 4491, 4543, 4800, 4859, 4975, 5214, 5273, 5435, 5483, 5509, 5587, 5939, 5961, 6261], '19:': [607], '11-26Crossref': [608], '(170)': [611], '4Lester': [614, 1382, 4363], 'H.A.': [615, 1214, 1383, 4364], 'Dibas': [616, 1201, 1384, 4365], 'M.I.': [617, 1202, 1385, 4366], 'Dahan': [618, 1386, 4367], 'D.S.': [619, 740, 1200, 1387, 4368], 'Leite': [620, 1388, 4369], 'J.F.': [621, 1389, 4370], 'Dougherty': [622, 1211, 1390, 4371], 'D.A.': [623, 1147, 1182, 1212, 1391, 1486, 1544, 4372, 4469, 5135, 6106], 'Trends': [624, 892, 1392, 4373], '2004;': [626, 651, 1222, 1272, 1341, 1394, 2246, 4375, 5298, 5485, 5511, 5941, 6263], '27:': [627, 896, 1395, 4376], '329-336Abstract': [628, 1396, 4377], 'Full': [629, 631, 777, 779, 898, 900, 1047, 1171, 1275, 1277, 1344, 1346, 1397, 1399, 1456, 1458, 2249, 2251, 4378, 4380, 4496, 4498, 5488, 5490, 5514, 5516, 5944, 5946, 5966, 5968, 6266, 6268], 'Text': [630, 632, 778, 780, 899, 901, 1048, 1172, 1276, 1278, 1345, 1347, 1398, 1400, 1457, 1459, 2250, 2252, 4379, 4381, 4497, 4499, 5489, 5491, 5515, 5517, 5945, 5947, 5967, 5969, 6267, 6269], 'PDF': [633, 781, 902, 1049, 1173, 1279, 1348, 1401, 1460, 2253, 4382, 4500, 5492, 5518, 5948, 5970, 6270], '(361)': [636, 1404, 4385], '5Olsen': [639], 'R.W.': [640], 'Chang': [641], 'C.S.': [642], 'Li': [643], 'G.': [644], 'Hanchar': [645], 'H.J.': [646], 'Wallner': [647], 'M.': [648, 807, 860, 1149, 1162, 1318, 1368, 1675, 2004, 2105, 4349, 6240], 'Biochem.': [649, 893], 'Pharmacol.': [650], '68:': [652], '1675-1684Crossref': [653], '(59)': [656], 'Scholar),': [658, 1176, 1196, 5222, 5242, 5259, 5281], 'are': [659, 792, 1026, 1076, 1086, 1095, 2189, 2870, 3120, 4921, 4954, 4996, 5009, 5196, 5308, 5645, 5658, 5725, 6015, 6236, 6375], 'assembly': [663], 'homologous': [666, 4407, 4793, 6505], 'subunits': [667, 791, 3265, 4529, 5131, 6454], 'around': [668, 5398], 'axis.': [672, 5405, 6477], 'Each': [673], 'has': [675, 853, 1135, 1634, 1949, 5409, 5842], '∼200': [677], 'amino': [678], 'N-terminal': [681, 1065], 'domain': [682, 694, 1134], 'forms': [684], 'agonist': [686, 5691], 'binding': [687, 3583, 5160, 5809], 'sites': [688, 2158], 'similarly': [691], 'sized': [692], 'C-terminal': [693], 'four': [696], 'α-helical,': [697], '(M1,': [700], 'M2,': [701], 'M3,': [702, 972], 'M4).': [704], 'For': [705, 1091, 1868, 2058, 3370, 4129], 'expression': [710], 'α,': [712], 'β,': [713], 'subunits,': [716, 725, 728], 'most': [718, 6011], 'common': [719], 'stoichiometry': [721], 'one': [730, 1885, 2456, 2717, 3300, 4766, 5053, 5185], '(6Chang': [733], 'Y.': [734, 911, 1667, 5288, 5296, 5419, 5571], 'Wang': [735], 'R.': [736, 768, 1679, 4832, 5266], 'Barot': [737], 'S.': [738, 1220, 2027, 2048, 5499, 5777, 5785, 5876, 6515], 'Weiss': [739], 'J.': [741, 757, 771, 811, 863, 878, 925, 1105, 1165, 1180, 1269, 1321, 1338, 1371, 1445, 1450, 1484, 1542, 1590, 1671, 1891, 1972, 2019, 2108, 2243, 4352, 4390, 4467, 4485, 4490, 4541, 4798, 4857, 4973, 5133, 5212, 5271, 5433, 5482, 5508, 5585, 5938, 5955, 5960, 6104, 6243, 6260], '1996;': [743, 866, 1324, 1374, 2029, 2111, 4355, 6246], '16:': [744], '5415-5424Crossref': [745], '7Tretter': [749], 'V.': [750, 1673], 'Ehya': [751], 'N.': [752, 913, 924, 1104, 1589, 1602, 4389, 4540, 4797, 4834, 5421, 5432, 5573, 5584], 'Fuchs': [753], 'K.': [754, 800, 1795], 'Sieghart': [755], 'W.': [756, 1990, 5262], '1997;': [759], '17:': [760], '2728-2737Crossref': [761], '8Baumann': [765], 'S.W.': [766], 'Baur': [767], 'Sigel': [769], 'E.': [770, 5292], 'Chem.': [773, 1167, 1271, 1340, 1452, 2245, 4492, 5484, 5510, 5940, 5962, 6262], '2001;': [774, 817, 880, 1189, 1493, 1551, 2050, 4476, 5142, 5252, 6113], '276:': [775], '36275-36280Abstract': [776], '(188)': [784], 'Viewed': [787], 'from': [788, 981, 1791, 1835, 2293, 2604, 4007, 4037, 4062, 4092, 4203, 4233, 4778, 4899, 5044, 5068, 5382, 5538, 6384, 6474], 'above,': [789], 'arranged': [793], 'counterclockwise': [794], 'order': [797, 3509, 4342, 5163], 'βαγβα': [798], '(9Brejc': [799], 'van': [801, 808], 'Dijk': [802], 'W.J.': [803], 'Klaassen': [804], 'R.V.': [805], 'Schuurmans': [806], 'Der': [809], 'Oost': [810], 'Smit': [812], 'A.B.': [813], 'Sixma': [814], 'T.K.': [815], 'Nature.': [816, 914, 1603, 1657, 1680, 5234, 5251, 5422, 5574], '411:': [818], '269-276Crossref': [819], '(1579)': [822], 'Ca2+-free': [830], 'solution': [833, 2397, 2428, 2463, 2520, 4181, 4202, 4209, 4238, 4293, 4314], 'dithiothreitol.': [836], 'structure': [842, 851, 4404, 4418, 4790, 4872, 5050, 6193, 6429, 6502], 'probably': [844], 'Torpedo': [848], 'ACh': [849, 989, 1585, 4408, 4794, 4870, 5413, 6506], 'been': [854, 1136, 1635, 1647, 1950, 5410, 5843], 'solved': [855], '4-Å': [857, 987, 1578, 4402, 4788, 5049], 'resolution': [858, 988, 1579, 4403, 4789], '(10Xu': [859, 1317, 1367, 2104, 4348, 6239], 'Akabas': [861, 1163, 1185, 1267, 1319, 1336, 1369, 1448, 1489, 1547, 2106, 2241, 4350, 4472, 4488, 5138, 5480, 5936, 5958, 6109, 6241, 6258], 'M.H.': [862, 1145, 1164, 1186, 1268, 1320, 1337, 1370, 1449, 1490, 1548, 2107, 2242, 4351, 4473, 4489, 5139, 5481, 5937, 5959, 6110, 6242, 6259], 'Gen.': [864, 1322, 1372, 2109, 4353, 6244], 'Physiol.': [865, 1323, 1373, 2110, 4354, 6245], '107:': [867, 1325, 1375, 2112, 4356, 6247], '195-205Crossref': [868, 1326, 1376, 2113, 4357, 6248], '(179)': [871, 1329, 1379, 2116, 4360, 6251], '11Teissere': [874], 'J.A.': [875, 2042], 'Czajkowski': [876, 1183, 1487, 1545, 4470, 5136, 6107], 'C.': [877, 1042, 1184, 1488, 1546, 4471, 4840, 5137, 5503, 6108], '4977-4986Crossref': [882], '12Cromer': [886], 'B.A.': [887], 'Morton': [888], 'C.J.': [889], 'Parker': [890], 'M.W.': [891], 'Sci.': [894, 1218, 1992, 2025, 2046, 5783, 5874, 6513], '280-287Abstract': [897], '(173)': [905], '13Miyazawa': [908], 'Fujiyoshi': [910, 5418, 5570], 'Unwin': [912, 1587, 5420, 5572], '2003;': [915, 1681, 5423, 5575], '423:': [916, 1682, 5424, 5576], '949-955Crossref': [917, 5425, 5577], '(1081)': [920, 5428, 5580], '14Unwin': [923, 4388, 5431, 5583], '2005;': [928, 1108, 1453, 1593, 4393, 4493, 4544, 4801, 5436, 5588, 5787, 5963], '346:': [929, 1109, 1594, 4394, 4545, 4802, 5437, 5589], '967-989Crossref': [930, 1110, 1595, 4395, 4546, 4803, 5438, 5590], '(1418)': [933, 1113, 1598, 4398, 4549, 4806, 5441, 5593], 'lined': [941], 'form': [948, 1720, 1865, 2130, 2153, 2208, 3619, 5119], 'inner': [950, 956], 'ring': [951, 957, 965, 5391], 'α-helices.': [954], 'helices': [959, 967, 5393], 'surrounded': [961], 'outer': [964, 5390], 'M1,': [971], 'M4': [974], 'separate': [977], 'lipid': [983], 'bilayer.': [984], 'halves': [994, 6492], 'appear': [999], 'packed,': [1001], 'narrow': [1004, 5557], 'channel,': [1008], 'inferred': [1009, 3697], 'be': [1011, 2610, 3467, 3631, 3703, 3738, 4776, 5707, 5763, 5833, 5915, 6058, 6141, 6161, 6189, 6199, 6223, 6341, 6446], 'gate,': [1014], '9′': [1018, 1479, 5564], '14′': [1020, 2096, 5566], '4Positions': [1021], 'segment': [1025, 1240, 4768, 4774, 5022, 5037, 5347, 5377], 'identified': [1027], 'index': [1032], 'numbers': [1033], 'facilitate': [1035], 'comparison': [1036, 3116], '(37Miller': [1041], 'Neuron.': [1043], '1989;': [1044, 4845], '2:': [1045], '1195-1205Abstract': [1046], '(150)': [1052], 'this': [1056, 1945, 3254, 3932, 3946, 4130, 4447, 6287, 6572], 'absolutely': [1059], 'conserved': [1060], 'basic': [1061], 'residue': [1062, 2097], 'at': [1063, 1289, 1420, 1503, 2285, 2390, 2407, 2458, 2506, 2515, 2521, 2593, 3070, 3088, 4530, 4566, 4571, 4749, 5124, 5633, 5696], 'numbered': [1070, 1077, 1087], '0′.': [1071], 'Residues': [1072, 1082], 'toward': [1073, 1083, 5192, 5388], 'C-terminus': [1075], '1′,': [1078], '2′,': [1079], '3′,': [1080], 'etc.': [1081, 1090], 'N-terminus': [1085], '-1′,': [1088], '-2′,': [1089], '0′,': [1093], 'α1R255,': [1098], 'β1R250,': [1099], 'γ2R265.': [1101], 'levels': [1102, 6419], '(14Unwin': [1103, 1588, 4539, 4796], 'This': [1116, 1830, 3549, 3596, 3670, 3730, 3917, 4592, 4960, 5032, 5553, 6168, 6433], 'provides': [1117, 4410], 'static': [1119, 4412], 'picture': [1120], 'state.': [1124, 6019, 6427], 'Information': [1125], 'dynamic': [1128, 5920, 6033], 'protein': [1129, 1954, 4901, 4958, 5858, 5868, 5909], 'membrane-spanning': [1133], 'obtained': [1137], 'using': [1138, 2232, 2264, 2560, 3105, 4552], 'substituted': [1140, 1288, 1414, 1476, 2082, 2126, 2135, 5123], 'accessibility': [1142, 1232, 1251, 1303, 2084], 'method': [1143, 1233, 2085], '(15Akabas': [1144], 'Stauffer': [1146], 'Xu': [1148], 'Karlin': [1150, 2039], 'Science.': [1152], '1992;': [1153, 1894, 1975, 4860, 4976, 5215], '258:': [1154], '307-310Crossref': [1155], '(595)': [1158], '16Xu': [1161], '1993;': [1168], '268:': [1169], '21505-21508Abstract': [1170], '(17Horenstein': [1179, 1483, 1541, 4466, 5132, 6103], 'Wagner': [1181, 1485, 1543, 4468, 5134, 6105], '4:': [1190, 1494, 1552, 4477, 5143, 6114], '477-485Crossref': [1191, 1495, 1553, 4478, 5144, 6115], '(136)': [1194, 1498, 1556, 4481, 5147, 6118], 'fluorescence': [1198], '(18Dahan': [1199], 'Petersson': [1203], 'E.J.': [1204], 'Auyeung': [1205], 'V.C.': [1206], 'Chanda': [1207], 'B.': [1208, 4836, 5870, 6509], 'Bezanilla': [1209, 1655, 5232], 'F.': [1210, 1656, 5233], 'Lester': [1213], 'Proc.': [1215, 2022, 2043, 5780, 5871, 6510], 'Natl.': [1216, 2023, 2044, 5781, 5872, 6511], 'Acad.': [1217, 2024, 2045, 5782, 5873, 6512], 'U.': [1219, 2026, 2047, 5784, 5875, 6514], '101:': [1223], '10195-10200Crossref': [1224], '(77)': [1227], 'Substituted': [1230], 'studies': [1234, 6526], 'β1': [1237, 3152, 3264, 3362], 'GABA': [1245, 1443, 2399, 2590, 2617, 2637, 2674, 2775, 2846, 2852, 2884, 2914, 2925, 2938, 2956, 2962, 2995, 3030, 3728, 3847, 3879, 3995, 4027, 4081, 4144, 4159, 4703, 4716, 5813, 6008, 6102], 'showed': [1246, 4557, 5112], 'high': [1248, 1261, 2268, 2690, 2741, 4207, 4236], 'degree': [1249], 'above': [1255, 3563], '11′,': [1256], 'suggesting': [1257, 4653, 4950], 'loose': [1258, 6487], 'packing': [1259, 6488], 'and/or': [1260], 'mobility': [1262, 1316, 1955, 4424], '(19Goren': [1263, 2237, 5476, 5932], 'E.N.': [1264, 1333, 2238, 5477, 5933, 6255], 'Reeves': [1265, 1334, 2239, 5478, 5934, 6256], '279:': [1273, 1342, 2247, 5486, 5512, 5942, 6264], '11198-11205Abstract': [1274, 1343, 2248, 5487, 5943, 6265], '(41)': [1282, 1351, 2256, 5495, 5951, 6273], 'contrast,': [1286, 1502, 6066], 'cytoplasmic': [1291, 1355, 5452, 5544], '2′': [1297, 5463], '6′': [1299, 1505, 1530, 5127, 5152], 'had': [1300, 2549, 2627, 3011, 3192, 3306, 3453, 3597, 3723], 'limited': [1302, 4178], 'consistent': [1304, 3922, 6484], 'being': [1311], 'tightly': [1312, 5467, 5821], 'low': [1315], '19Goren': [1332, 6254], 'contains': [1360], 'size': [1362], 'charge': [1364], 'selectivity': [1365], 'filters': [1366], 'for': [1415, 1477, 1706, 2127, 2136, 2313, 2387, 2452, 2634, 2666, 2855, 2867, 2928, 3178, 3189, 3420, 3445, 3593, 3746, 3755, 3796, 3871, 3896, 3910, 3983, 4033, 4088, 4106, 4122, 4261, 4281, 4586, 4688, 5055, 5063, 5164, 5198, 5330, 5412, 5765, 5892, 6137, 6545, 6564, 6569], 'aligned': [1416, 4112, 4747, 4784, 4885, 5165], 'channel-lining': [1418, 4339, 5126, 5630, 5755, 6237, 6411], '20′': [1422, 4433, 6085, 6418], 'level': [1423, 1506, 3429, 3433, 4752, 5153, 5635], 'show': [1424], 'across': [1432], 'lumen': [1435], '(20Horenstein': [1444], 'Riegelhaupt': [1446, 4486, 5956, 6563], 'P.': [1447, 4487, 4842, 5957], '280:': [1454, 4494, 5964], '1573-1581Abstract': [1455, 4495, 5965], '(21)': [1463, 4503, 5973], 'αβ': [1467], 'no': [1469, 3193, 3307, 3598, 3724, 3734, 6327], '13′': [1481, 4113, 4131, 4751, 5007, 6416], 'observed': [1508, 4962, 6497], 'state-dependent': [1509], 'not': [1519, 1832, 1914, 2453, 2712, 3498, 3617, 3673, 3781, 4149, 4177, 4318, 4942, 6057, 6211], 'its': [1521, 5041, 5045], 'absence,': [1522], 'adjacent': [1527, 4528, 4772, 5130, 5168, 5740, 6219], 'subunits.': [1528, 6220], 'significantly': [1534, 2910, 3165, 3387, 4005, 4060, 4639, 4697, 5322], 'increased': [1535, 3388, 4138], "channels'": [1537], 'open': [1539, 4164, 4344, 4723, 5555, 5668, 5710, 5732, 5774, 5804, 5829, 6054, 6293], 'probability': [1540], 'suggested': [1560, 1613, 1636, 5449], 'gating': [1563, 4332, 5415, 5475, 5679, 5894], 'might': [1564, 3579, 5832, 6222, 6379], 'rotation': [1567, 4459, 5078, 5094, 5200, 5313, 5397, 6463], 'Based': [1572, 2078], '9-': [1576], 'electron': [1580], 'density': [1581], 'maps': [1582], 'receptor,': [1586], '21Unwin': [1601], '373:': [1605], '37-43Crossref': [1606], '(909)': [1609], 'Scholar)': [1611, 4551, 5794], 'during': [1620, 5474, 5534, 5677, 6456], 'much': [1626], 'smaller': [1627, 3166], 'extent.': [1628], 'voltage-dependent': [1630, 5223], 'potassium': [1631, 4208], 'it': [1633, 2163, 3773, 5379, 5692, 5841, 6123, 6214], 'S4': [1639], 'voltage': [1640, 2501], 'sensor': [1641], 'rotates,': [1642], 'models': [1645], 'have': [1646, 1691, 4511, 5448, 5924], 'proposed': [1648, 5411], '(22Cha': [1649, 5226], 'Snyder': [1651, 5228], 'G.E.': [1652, 5229], 'Selvin': [1653, 5230], 'P.R.': [1654, 5231], '1999;': [1658, 5235], '402:': [1659, 5236], '809-813Crossref': [1660, 5237], '(435)': [1663, 5240], '23Jiang': [1666], 'Lee': [1668], 'Chen': [1670], 'Ruta': [1672], 'Cadene': [1674], 'Chait': [1676], 'B.T.': [1677], 'MacKinnon': [1678], '33-41Crossref': [1683], '(1636)': [1686], 'Here': [1689], 'probe': [1697], 'evidence': [1707, 6328], 'ability': [1712, 2122, 2204, 2696, 3478, 5827], 'pair': [1715, 3933, 3947, 4132, 6383], 'depends': [1724, 1741], 'oxidizing': [1730, 1775, 1814, 1842, 3408, 3636, 4614], 'environment': [1731, 1843, 3637, 4615], "pair's": [1735], 'collision': [1736, 1739, 3941, 4598, 4656, 4744], 'frequency.': [1737], 'frequency': [1740, 3942, 4599, 4657, 4745, 6364, 6388], 'average': [1744, 1919], 'separation': [1745, 1920, 3999, 4031, 4086, 4780, 4881, 4909, 4919, 6300], 'distance': [1746, 4032, 4087, 4815, 4939, 6301], 'sulfhydryls,': [1749], 'their': [1750, 5665, 6471], 'relative': [1751, 1862, 2170, 3024, 4597, 4769, 5737], 'orientation': [1752, 6393], 'protein,': [1755], "protein's": [1758], 'flexibility/mobility': [1759], 'residues.': [1766, 3242, 3339, 6337], '(Cu:phen)': [1771], 'create': [1773], 'environment.': [1776], 'Cu:phen': [1777, 2665, 2704, 2834, 2918, 2953, 2974, 3002, 3052, 3293, 3410, 3482, 3489, 3554, 3577, 3640, 3648, 3715, 3827, 3856], 'catalyzes': [1778], 'reactive': [1782], 'oxygen': [1783, 1793, 1819], 'species': [1784], 'such': [1785], 'as': [1786, 1851, 2234, 2495, 2872, 3043, 3122, 3833, 3851, 4197, 5378, 5548, 6468, 6470], 'superoxide': [1787], 'hydroxyl': [1789], 'radicals': [1790], 'molecular': [1792], '(24Kobashi': [1794], 'Biochim.': [1796], 'Biophys.': [1797], 'Acta.': [1798], '1968;': [1799], '158:': [1800], '239-245Crossref': [1801], '(161)': [1804], 'Spontaneous': [1807, 1847, 3340], 'indicates': [1811], 'mildly': [1813], 'conditions': [1815], 'due': [1816, 2706, 3492, 3580, 3802], 'ambient': [1818], 'our': [1821, 2080, 4180], 'buffer': [1822], 'sufficient': [1824, 6059, 6363, 6387], 'promote': [1826], 'formation.': [1829, 4312, 6401], 'fundamentally': [1833], 'different': [1834, 3988, 4006, 4061], 'more': [1841, 2454, 2673, 3635, 4613, 5089], 'created': [1844, 3638, 4616], 'Cu:phen.': [1846, 2498, 2787, 2849, 3476], 'compared': [1852, 3751, 4704], 'Cu:phen-induced': [1854, 3756, 3955], 'simply': [1857], 'measure': [1859], 'propensity': [1863], 'bonds.': [1867, 2657, 3776], 'form,': [1873], 'carbons': [1877, 1925, 4827], 'must': [1878, 5179, 5773, 6340], 'come': [1879, 5172], 'within': [1881, 1944, 3229, 5333, 6309], '5.6': [1882, 1927], 'Å': [1883, 4830], 'another': [1886], '(25Careaga': [1887, 1968, 4969, 5208], 'C.L.': [1888, 1969, 4854, 4970, 5209], 'Falke': [1889, 1970, 4855, 4971, 5210], 'J.J.': [1890, 1971, 4856, 4972, 5211], '226:': [1895, 1976, 4861, 4977, 5216], '1219-1235Crossref': [1896, 1977, 4862, 4978, 5217], '(218)': [1899, 1980, 4865, 4981, 5220], 'It': [1902, 3058, 3066, 5976, 6221], 'important': [1904, 5764], 'recognize': [1906], 'does': [1913, 4941], 'imply': [1915], 'time': [1918, 3049, 3071, 3087, 3753, 3794, 3810, 3858, 3869, 3894, 3919, 3952, 3968, 4019, 4073, 4104, 4136, 4174, 4187, 4251, 4271, 4299, 4306, 4327, 5699, 6050], 'Å.': [1928, 4916, 4937], 'One': [1929], 'can': [1930, 1941, 2680, 4739, 4775, 4931], 'infer': [1931, 3211, 3317, 3443], 'course': [1935], 'cysteines': [1940, 6359], 'approach': [1942], 'distance.': [1946], 'study': [1953], 'relationships': [1958], 'water-soluble': [1963], 'integral': [1965], 'membrane': [1966, 4195], 'proteins': [1967, 5840], '26Regan': [1983], 'L.': [1984], 'Rockwell': [1985], 'Wasserman': [1987], 'Z.': [1988], 'DeGrado': [1989], 'Protein': [1991, 4843], '1994;': [1993], '2419-2427Crossref': [1995], '(25)': [1998], '27Yu': [2001], 'H.': [2002, 2038, 5294, 5501], 'Kono': [2003], 'McKee': [2005], 'T.D.': [2006], 'Oprian': [2007], 'D.D.': [2008], 'Biochemistry.': [2009, 5297], '34:': [2011], '14963-14969Crossref': [2012], '(119)': [2015], '28Wu': [2018], 'Kaback': [2020], 'H.R.': [2021], '93:': [2030], '14498-14502Crossref': [2031], '(75)': [2034], '29Hastrup': [2037], 'Javitch': [2041], '98:': [2051], '10055-10060Crossref': [2052], '(172)': [2055], 'took': [2062, 4295], 'advantage': [2063], 'fact': [2066], 'αβγ': [2069, 3297, 3528], 'there': [2071], 'γ-α': [2075, 4589, 4650], 'earlier': [2081], 'predicted': [2092], 'γ2M2': [2095], 'lies': [2098], 'interface': [2103, 2572], 'probed': [2120, 2202, 4512], 'α112′': [2137], 'α116′': [2139, 4577, 4607, 5364, 5607, 5991], 'GABA.': [2145, 2900, 3966, 4711, 4759, 6002, 6082, 6167], 'hypothesized': [2147], 'if': [2149, 2612, 5816], 'could': [2152, 3466, 3630, 3702, 3737, 5023, 5118, 5394, 5546], 'multiple': [2157, 2184, 3115], 'segment,': [2162, 5457], 'suggest': [2165], 'moving': [2169, 5729], 'Our': [2175], 'data': [2176, 2571, 3119, 4902], 'γ14′C': [2179], 'α-substituted': [2185], 'separated': [2190, 2591, 4997, 5010], '∼160°': [2192], 'circumference': [2195, 4986], 'helix.': [2199], 'α111′C': [2212], 'Mutagenesis': [2223], 'Oocyte': [2225], 'Expression—All': [2226], 'made': [2231, 2422, 2469, 3005], 'PCR': [2233], 'described': [2235, 3562], 'previously': [2236, 4963, 5113, 5931], 'mRNA': [2259, 2277, 2379], 'synthesized': [2261], 'vitro': [2263], 'AmpliCap': [2266], 'T7': [2267], 'yield': [2269], 'message': [2270], 'maker': [2271], 'kit': [2272], '(Epicenter': [2273], 'Technologies,': [2274], 'Madison,': [2275], 'WI).': [2276, 2298], 'dissolved': [2279], 'diethylpyrocarbamate-treated': [2281], 'water': [2282, 2402], 'stored': [2284, 2406, 2451], '-80': [2286], '°C.': [2287, 2392, 2409, 2460], 'Xenopus': [2288], 'laevis': [2289], 'specimens': [2290], 'purchased': [2292], 'Nasco': [2294], 'Science': [2295], '(Fort': [2296], 'Atkinson,': [2297], 'Stage': [2299], 'V-VI': [2300], 'oocytes': [2301, 3295, 3650, 3717], 'defolliculated': [2303], 'incubation': [2305], '2': [2307, 2324, 4820, 4934], 'mg/ml': [2308], '1A': [2310], 'collagenase': [2311], '(Sigma)': [2312, 2400, 2420], '75': [2314, 4262], 'min.': [2315, 2636, 3595], 'Oocytes': [2316, 2361, 3243], 'washed': [2318], 'OR2': [2320], '(82.5': [2321], 'mm': [2322, 2325, 2328, 2332, 2352, 2395, 2431, 2434, 2437, 2441, 2466, 2630, 2735, 2763, 2893, 3187, 3279, 3385, 3418, 3535, 3591, 3681, 3692, 4211, 4214, 4217, 4221], 'NaCl,': [2323, 2432, 4215], 'KCl,': [2326, 2435, 4212], '1': [2327, 2410, 2667, 2734, 3282, 3367, 3590, 3594, 3680], 'MgCl2,': [2329, 2438, 4218], '5': [2331, 2595], 'HEPES;': [2333], 'pH': [2334, 2443, 4223], 'adjusted': [2335], '7.5': [2337], 'NaOH)': [2339], 'kept': [2341, 2383], 'OR3': [2343, 2385], '(70%': [2344], "Leibovitz's": [2345], 'L-15': [2346], 'medium': [2347, 2386], '(Invitrogen)': [2348], 'supplemented': [2349], '10': [2351, 2440, 2629, 2762, 2892, 3186, 3278, 3384, 3417, 3534, 3691, 4220, 4301], 'HEPES,': [2353, 2442, 4222], '50': [2354, 2358, 2369], 'μg/ml': [2355, 2359], 'tetracycline,': [2356], 'gentamicin).': [2360], 'injected': [2363], '24': [2364], 'h': [2365], 'after': [2366, 2848, 3033, 3434], 'isolation': [2367], 'nl': [2370], '1:1:1': [2373], 'mixture': [2374], 'rat': [2376], 'α1/β1/γ2S': [2377], '(200': [2380], 'pg/nl)': [2381], '2-5': [2388], 'days': [2389], '17': [2391], 'Reagents—A': [2393], '100': [2394, 2465, 2487], 'stock': [2396, 2412, 2462], 'aliquoted': [2404], '-20': [2408, 2459], 'm': [2411, 2539, 2547], 'solutions': [2413], 'dithiothreitol': [2415], '(DTT;': [2416], 'Sigma)': [2417], 'o-phenanthroline': [2419, 2474, 2493], 'nominally': [2424], 'calcium-free': [2425], "Ringer's": [2427], '(CFFR;': [2429], '115': [2430], '2.5': [2433, 4213], '1.8': [2436, 4216], '7.5)': [2444], 'dimethyl': [2446], 'sulfoxide,': [2447], 'respectively,': [2448], 'aliquoted,': [2449], 'month': [2457], 'CuSO4': [2467, 2472, 2489], 'water.': [2471], 'mixed': [2476], 'CFFR': [2478, 2519, 2598, 4204, 4234], 'directly': [2479, 2640], 'before': [2480, 2916, 5186], 'use': [2481], 'final': [2484, 2771, 3081], 'concentration': [2485, 3785], 'μm': [2488, 2492, 2497, 2664, 2851, 2883, 3292, 3647, 3826], '200': [2491], '100:200': [2496, 2663, 3291, 3646], 'Electrophysiology—Two': [2499], 'electrode': [2500, 2530], 'clamp': [2502], 'recordings': [2503], 'conducted': [2505], 'room': [2507], 'temperature': [2508], '250-μl': [2511], 'chamber': [2512], 'continuously': [2513], 'perfused': [2514], '5-6': [2516], 'ml/min': [2517], 'holding': [2523], 'potential': [2524], '-60': [2526], 'mV.': [2527], 'ground': [2529], 'connected': [2532], 'bath': [2535], 'via': [2536], 'KCl/agar': [2540], 'bridge.': [2541], 'Glass': [2542], 'microelectrodes': [2543], 'filled': [2544], 'KCl': [2548], 'resistance': [2551], '<2': [2553], 'megaohms.': [2554], 'Data': [2555, 4874], 'acquired': [2557], 'analyzed': [2559], 'TEV-200': [2562], 'amplifier': [2563], '(Dagan': [2564], 'Instruments,': [2565, 2574], 'Minneapolis,': [2566], 'MN),': [2567], 'Digidata': [2569], '1322A': [2570], '(Axon': [2573, 2582], 'Union': [2575], 'City,': [2576], 'CA),': [2577], 'pClamp': [2579], '8': [2580], 'software': [2581], 'Instruments).': [2583], 'Currents': [2584, 2606], 'elicited': [2586], 'applications': [2588, 2975, 3003, 3823], 'least': [2594], 'min': [2596, 3191, 3422], 'wash': [2599, 2934], 'allow': [2601, 6352, 6368, 6395], 'complete': [2602], 'recovery': [2603], 'desensitization.': [2605], 'judged': [2608], 'stable': [2611], 'variation': [2614], 'consecutive': [2616], 'pulses': [2618, 2676, 2951, 2958, 3032], '<5%.': [2620], 'Bond-induced': [2622], 'Inhibition—Once': [2623], 'GABA-induced': [2624, 2816, 3018, 3198, 3268, 3312, 3364, 3391, 3398, 3425, 3545, 3602, 3666, 3800, 3830, 3840], 'control': [2625], 'currents': [2626, 2863, 2997, 3021, 3040, 3157, 3161, 3199, 3269, 3313, 3365, 3392, 3426, 3546, 3603, 3667, 3801, 3832, 3841], 'stabilized,': [2628], 'DTT': [2631, 2642, 2679, 2698, 2764, 2779, 2821, 2829, 2894, 3188, 3280, 3386, 3419, 3439, 3470, 3485, 3536, 3693], 'applied': [2633, 2927, 3589], 'reapplied': [2639], 'following': [2641, 2818], 'determine': [2644, 4943, 6280], 'potentiation': [2648, 2791], 'produced': [2649], 'reduction': [2652, 2795], 'cells': [2659], 'treated': [2661], 'min,': [2668], 'then': [2670], 'test': [2675, 2772, 2879, 2897, 2907, 2939, 2957, 2963, 2996, 3019, 3031, 3831], 'applied.': [2678], 'bind': [2687], 'Cu2+': [2688, 2714, 2739, 3582], 'affinity.': [2691], 'confirm': [2693], 'reverse': [2700, 2753, 2783, 3480], 'effects': [2702, 3817], 'chelation': [2715], 'residues,': [2724], 'assayed': [2726], 'effect': [2728, 2755, 2785, 2807, 2832, 2866, 3194, 3308, 3483, 3490, 3599, 3725], '1-min': [2731, 3288, 3404, 3643, 3677], 'application': [2732, 2760, 2819, 2890, 3035, 3276, 3289, 3382, 3405, 3415, 3437, 3532, 3555, 3578, 3644, 3678, 3689, 3713, 3857], 'EGTA.': [2736], 'EGTA': [2737, 2750, 3592, 3682], 'chelates': [2738], 'affinity': [2742], 'cannot': [2744, 4728, 6279], 'bond.': [2748], 'If': [2749], 'failed': [2751], 'Cu:phen,': [2757], 'second': [2759, 2906], '(3': [2765, 3537], 'min)': [2766, 3538], 'followed': [2768, 2886, 3111], 'pulse': [2773, 2880, 2898, 2908, 2940, 2964, 3020], 'able': [2781], 'attributed': [2792], 'calculated': [2802, 2836, 3813], 'equation': [2805, 3057, 4246], 'percentage': [2806, 2865], '=': [2808, 3059, 3661, 4258, 4278], '[(IDTT': [2809], '-': [2810, 3061], 'I)/I]·100,': [2811], 'where': [2812, 2859, 3065], 'IDTT': [2813], 'current': [2817, 2826, 2847, 2902, 2915, 2946, 2965, 3027, 3069, 3094, 3399, 3848, 4196, 4226, 4267, 4286], 'I': [2823, 2843], 'prior': [2827, 3456], 'treatment.': [2830], 'way': [2840], 'except': [2841, 2858], '500': [2850, 2882], 'all': [2856, 5701], 'specified.': [2860], 'maximal': [2862], 'each': [2868, 3134, 3350, 5193], 'reagent': [2869, 3409], 'presented': [2871, 3121], 'mean': [2874, 3124], '±': [2875, 3125, 3658, 4001, 4015, 4042, 4044, 4046, 4048, 4050, 4052, 4254, 4263, 4274], 'S.E.': [2876, 3126], 'Reoxidation': [2877], 'Rates—A': [2878], '3-min': [2889, 3275, 3381, 3688], 'magnitude': [2903, 2966, 3016], 'larger': [2911, 5323], 'DTT.': [2917, 3037], '(50:100': [2919], 'μm)': [2920], 'without': [2923], 'saturating': [2924], 's.': [2930], 'After': [2931], '5-min': [2933], 'CFFR,': [2936], 'applied,': [2942], 'peak': [2945], 'measured.': [2948], 'brief': [2950, 3820], 'alternating': [2954], 'continued': [2959], 'until': [2960], 'reached': [2967, 2998], 'plateau.': [2969], 'durations': [2971], 'varied': [2976], '40': [2980], 's': [2981, 3890], 'depending': [2982], 'inhibition': [2987, 3573, 3656, 3671], 'caused': [2988, 3539, 3574, 3653], 'previous': [2991, 6406], 'pulse.': [2992], 'As': [2993], 'plateau,': [3000], 'longer': [3001], 'reaction': [3010, 6063, 6135], 'gone': [3012], 'completion.': [3014], 'normalized': [3023, 3039, 3843], 'plotted': [3042, 3850], 'function': [3045, 3853, 5767], 'cumulative': [3047, 3855], 'exposure': [3048], 'fitted': [3054, 3860], '(I0': [3060], 'I∞)exp(-t/τ)': [3062], '+': [3063, 3994], 'I∞,': [3064], 't,': [3072], 'I0': [3073], 'initial': [3076, 3531, 3846], 'current,': [3077, 3082], 'I∞': [3078], 'τ': [3084], 'which': [3089, 3772, 3937, 4731], '63%': [3090], 'total': [3093], 'decay': [3095, 3798], 'occurred.': [3096], 'Statistics—All': [3097], 'statistical': [3098], 'analyses': [3099], 'performed': [3101], 'Prism': [3103], '3.02': [3104], 'one-way': [3107], 'analysis': [3108], 'variance': [3110], 'Newman-Keuls': [3114], 'test.': [3117], 'All': [3118, 5596], 'Characterization': [3127], 'Individual': [3130], 'Cysteine': [3131, 3347], 'Mutants—Oocytes': [3132, 3348], 'expressing': [3133, 3244, 3296, 3349, 3651, 3718], 'individual': [3137, 3322, 3353, 5722], 'Cys-substitution': [3140], 'α112′C,': [3142, 3611], 'α113′C,': [3143, 3612, 4117], 'α114′C,': [3144], 'α115′C,': [3145], 'α116′C,': [3147], 'when': [3148, 3522], 'co-expressed': [3149], 'γ2,': [3154], 'displayed': [3155, 3267, 3363], 'GABA-activated': [3156], '(Fig.': [3158, 3208, 3314, 3393, 3440, 3547, 3564, 3604, 3668, 3694, 3866, 4247, 5065, 5369], '1).': [3159], 'α115′Cβ1γ2': [3163], 'those': [3168], 'nevertheless': [3175], 'sufficiently': [3176], 'large': [3177, 5312], 'purposes': [3180], 'experiments.': [3183], 'Application': [3184], 'subsequent': [3197, 3311, 3390, 3414, 3544, 3665, 3727], 'any': [3201, 5697], '2D).': [3209, 3284, 3548], 'none': [3213, 3319], 'α-engineered': [3226], 'endogenous': [3240, 3337], 'γ2': [3249, 3325], 'study,': [3255], 'γ214′C,': [3258, 3623], 'wild': [3260, 3360], 'unaffected': [3272, 3974], '(Figs.': [3281, 3366], '3B).': [3315], 'Bond': [3342, 3608, 3749], 'Formation': [3343], 'Pairs': [3345], '2).': [3369, 3394, 3605], 'double': [3374, 3448, 3742, 4244], 'mutants,': [3376, 3767, 3936], 'α115′Cβ1γ214′C': [3377], 'α116′Cβ1γ214′C,': [3379], 'increase': [3396, 3542, 3550], 'reversed': [3401, 3552, 3674, 3685], '(100:200': [3411], 'μm).': [3412], 'restored': [3423], 'first': [3436], '2E).': [3441, 3565], 'start': [3459], 'experiment.': [3462], 'reduced': [3468], 'reformed': [3472], 'oxidation': [3474, 3502, 3510], 'indicated': [3486], 'because': [3499, 3783, 6234], 'higher': [3508], 'states.': [3511, 4168, 4726, 6046, 6296], 'receptors.': [3529], 'An': [3530], 'manner': [3558], 'rule': [3567], 'out': [3568], 'possibility': [3570], 'Cys,': [3587], 'Cu:Phen-induced': [3606, 3747], 'Formation.—For': [3609], 'α114′C': [3614], 'did': [3616, 4317], 'tested': [3625], 'whether': [3626, 4151], 'application.': [3641], 'α113′Cβ1γ214′C': [3652], '(43%': [3657], '3;': [3659], 'n': [3660, 4257, 4277], '11)': [3662], '3).': [3669], '3A).': [3695], 'α113′-': [3707], 'γ214′-engineered': [3709], 'Cys.': [3710], 'α112′Cβ1γ214′C': [3720], 'α114′Cβ1γ214′C': [3722], 'currents.': [3729], 'finding': [3731, 6169], 'implies': [3732], 'mutants.': [3743, 3950], 'Time': [3744, 4057], 'Constants': [3745], 'Formation.—We': [3750], 'constants': [3754, 3779, 3811, 3870, 3953, 3969, 3981, 4020, 4074, 4175], 'three': [3764, 6075, 6095], '13′,15′': [3768], '16′,': [3770], 'Actual': [3777], 'determined': [3782], 'reactants': [3788], 'unknown,': [3790], 'rather': [3792], 'constant': [3795, 3895, 3920, 4003, 4058, 4105, 4137, 4188, 4252, 4272, 4307], 'determined.': [3808], 'determining': [3815], 'repeated': [3819], '(3-40': [3821], 's)': [3822], '50:100': [3825], 'illustrated': [3834], 'Fig.': [3836, 6323], '4A.': [3837], 'resultant': [3839], 'exponential': [3864, 4245], 'decayfunction': [3865], '4B).': [3867], 'similar,': [3888, 6190], '∼5': [3889], '(TABLE': [3891, 3915, 4145, 6320], 'ONE).': [3892, 3916, 4146], 'larger,': [3905], '∼9': [3906], 's,': [3907, 4256, 4276], 'lack': [3925], 'suggests': [3938, 4594, 6170], 'lower': [3944, 4665], 'measured': [3961, 4036, 4091, 4173, 4185], 'GABA.TABLE': [3979], 'ONETime': [3980], '(τ)': [3982], 'pairsMutantCu:phen': [3990], '(τ)naNumber': [3991, 3996], 'oocytesCu:phen': [3993], 'oocytesCα': [3998], 'distancessÅα13′Cγ13′C15': [4000], '2bTime': [4002], 'α15′Cγ14′C': [4009, 4064], 'α16′Cγ14′C': [4011, 4066], '(p': [4012, 4028, 4067, 4082], '<': [4013, 4029, 4068, 4083], '0.05)35': [4014], '0.7cSignificant': [4016], 'difference': [4017, 4071], '0.05)48.4dCα-Cα': [4030], 'respective': [4034, 4089], 'positions': [4035, 4090, 4608, 4748, 4785, 4884, 4995, 5008, 5166, 5365, 5567, 6350], '2BG9': [4039, 4094, 4904], 'atomic': [4040, 4095, 4905], 'coordinatesα13′Cγ14′C9': [4041], '3411': [4043], '336.6α15′Cγ14′C5': [4045], '155': [4047], '2310.4α16′Cγ14′C6': [4049], '144': [4051], '147.7a': [4053], 'Number': [4054], 'oocytesb': [4056], '0.05)c': [4069], 'Significant': [4070], '0.05)d': [4084], 'Cα-Cα': [4085, 6299], 'coordinates': [4096], 'Open': [4097], 'table': [4098], 'new': [4101], 'tab': [4102], 'positions,': [4114], 'γ214′C.': [4128], '3-fold': [4139], 'do': [4148, 6210], 'know': [4150, 6212], 'occurring': [4161], 'desensitized': [4167, 4725, 6018, 6045, 6186, 6295], 'ensure': [4170], 'exchange': [4182, 4294, 4315], 'rates,': [4183], 'change': [4191, 4227, 4335, 5473, 6061], 'resting': [4194, 5618, 5627, 5745], 'switched': [4199], 'perfusion': [4201], '(115': [4210], '7.5).': [4224], 'response': [4229], 'switch': [4232], 'K+': [4237, 5224], 'best': [4240], 'fit': [4241], '4C).': [4248], 'fast': [4250], '(0.6': [4253], '0.1': [4255], '5)': [4259, 4279, 6324], 'accounted': [4260, 4280], '6%': [4264], 'change.': [4268, 4287], 'slow': [4270], '(7.5': [4273], '1.2': [4275], 'only': [4282], '25%': [4283], 'major': [4289], 'component': [4290], 'place': [4296], 'scale': [4300], 'times': [4302, 6076, 6096], 'faster': [4303, 4698, 6077, 6097], 'Thus,': [4313, 4938, 5623, 5685, 5815, 5886, 6020], 'limit': [4319], 'measurement': [4321], 'constants.': [4328], 'conformational': [4334, 5472, 5751, 6450, 6533], 'view': [4413], 'little': [4420, 5471], 'insight': [4421], 'protein.': [4427, 5335, 5770], 'position,': [4434, 5464, 5734], 'deeper': [4449], 'nature': [4455], 'translation': [4461, 6472], 'both,': [4463], 'unknown': [4465], '20Horenstein': [4484, 5954], 'present': [4508, 5928, 6122], 'work': [4509, 5929], 'putative': [4536, 5642], 'trapping.': [4554], 'pairs.': [4591], 'result': [4593], 'similar.': [4610], 'phenanthroline,': [4622], 'pairs,': [4652], 'contrast': [4675], 'γ14′C,': [4682], 'γ13′C': [4693], 'α13′C': [4695], 'transitions': [4720], 'distinguish': [4729], 'occurring.': [4737], 'infer,': [4740], 'however,': [4741, 5721], 'greater': [4754], 'estimated': [4777], 'distances': [4781, 4920], 'bond,': [4812, 6208], 'center-to-center': [4814], 'separating': [4816, 4824], 'sulfurs': [4818], 'Å,': [4821, 4896, 6308], '∼5.6': [4829], '(30Sowdhamini': [4831], 'Srinivasan': [4833], 'Shoichet': [4835], 'Santi': [4837], 'D.V.': [4838], 'Ramakrishnan': [4839], 'Balaram': [4841], 'Eng.': [4844], '95-103Crossref': [4847], '(159)': [4850], '25Careaga': [4853], '(Protein': [4873], 'Bank': [4875], 'code': [4876], '2BG9)': [4877], 'carbon': [4880], 'γ14′': [4887], 'α15′': [4889, 5056, 5320], 'α16′': [4891], '∼10': [4893], '∼8': [4895], 'respectively': [4897], '(measured': [4898], 'bank': [4903], 'coordinate': [4906], 'file).': [4907], '∼7': [4915], 'sulfur-sulfur': [4918], 'dependent': [4922], 'specific': [4925, 6382, 6532], 'side': [4926, 5071], 'chain': [4927], 'rotamer': [4928], 'vary': [4932], 'alone': [4940], 'likelihood': [4945], 'formation,': [4949], 'certain': [4952], 'constrained': [4955], 'structure.': [4959], 'aspartate': [4966, 5205], 'chemotaxis': [4967, 5206], 'On': [4984], 'helix': [4990, 5042, 5199, 5404], '15′': [4992, 5005], 'arc': [5000, 5013], '100°,': [5002], 'whereas': [5003, 5542, 6152], '160°.': [5015], 'move': [5024, 5532], 'γ14′.': [5031], 'require': [5034, 5900], 'axis': [5043, 5386, 5400], 'direction': [5054, 5062], '80°': [5058], 'α13′': [5064, 5318, 6073], '5).': [5066, 5370], 'Looking': [5067], 'down': [5072], 'helix,': [5075], 'counter-clockwise': [5077], 'likely': [5090], 'clockwise': [5093], 'proximity.': [5101], 'Consistent': [5102], 'undergoing': [5107, 5646, 5660], 'At': [5150, 6083, 6121], 'involved': [5157, 6535], 'non-GABA': [5159], 'proximity,': [5175], 'asymmetrically': [5181], 'time,': [5184], 'next,': [5188], 'space,': [5191], 'other.': [5194], 'There': [5195, 6374], 'precedents': [5197], 'proteins,': [5202], 'including': [5203], 'cyclic': [5243], 'nucleotide-gated': [5244], '(31Johnson': [5246], 'Jr.,': [5247], 'J.P.': [5248], 'Zagotta': [5249], 'W.N.': [5250], '412:': [5253], '917-921Crossref': [5254], '(93)': [5257], 'bacteriorhodopsin': [5260], '(32Xiao': [5261], 'Brown': [5263], 'L.S.': [5264], 'Needleman': [5265], 'Lanyi': [5267], 'J.K.': [5268], 'Shin': [5269], 'Y.K.': [5270], '2000;': [5274], '304:': [5275], '715-721Crossref': [5276], '(55)': [5279], 'mitochondrial': [5284], 'ADP/ATP': [5285], 'carrier': [5286], '(33Kihira': [5287], 'Iwahashi': [5289], 'Majima': [5291], 'Terada': [5293], 'Shinohara': [5295], '43:': [5299], '15204-15209Crossref': [5300], '(27)': [5303], 'However,': [5306], 'concerned': [5309], 'required': [5314], 'seems': [5321], 'what': [5325], 'reasonable': [5327], 'expect': [5329], 'normal': [5331], 'combination': [5338], 'amount': [5351], 'α113′,': [5361, 5604, 5988], 'α115′,': [5362, 5605, 5989], 'sweeping': [5372], 'translates': [5380], 'away': [5381, 5537, 6473], 'outward': [5387, 5533], 'produce': [5395], 'Such': [5406], '(13Miyazawa': [5416, 5568], 'Recently,': [5444], 'others': [5447], 'vicinity': [5460], 'relatively': [5466, 5550], '34Panicker': [5498], 'Cruz': [5500], 'Arrabit': [5502], 'Suen': [5504], 'K.F.': [5505], 'Slesinger': [5506], 'P.A.': [5507], '28149-28158Abstract': [5513], '(20)': [5521], 'gating,': [5536], 'axis,': [5541], 'act': [5547], 'fixed': [5551], 'fulcrum.': [5552], 'agonist,': [5613], 'presumably': [5614], 'channel.': [5622, 5749], 'even': [5624], 'upper': [5638], 'Perhaps': [5650], 'sweeping/rotational': [5662], 'conformations,': [5670], 'occurs': [5676], 'non-concerted': [5683], 'fashion.': [5684], 'extremely': [5694], 'unlikely': [5695], 'given': [5698], '(i.e.': [5713], 'very': [5718], 'rare': [5719], 'event);': [5720], 'constantly': [5726], 'transiently': [5728], 'resulting': [5735], 'rapidly': [5775], '(35Chakrapani': [5776], 'Auerbach': [5778], '102:': [5788], '87-92Crossref': [5789], '(67)': [5792], 'energy': [5798, 5810, 6366], 'barrier': [5799], 'comparable': [5806], 'molecules.': [5814], 'extensive': [5824], 'contacts,': [5825], 'limited.': [5834], 'crystal': [5836], 'structures': [5837], 'shown': [5844], 'flexibility': [5847, 5888], 'inversely': [5852], 'proportional': [5853], 'contacts': [5859], 'rest': [5865], '(36Halle': [5869, 6508], '99:': [5879, 6518], '1274-1279Crossref': [5880, 6519], '(211)': [5883, 6522], 'rapid': [5893], 'contact': [5910], 'limited,': [5916], 'thus': [5917], 'allowing': [5918], 'documented': [5925], 'notable': [5978], 'prolonged': [6005], '(∼1': [6009], 'min),': [6010], 'similarity': [6022], 'indicate': [6030, 6408], 'fraction': [6048], 'spent': [6051], 'rate.': [6064], 'γ13′': [6071], 'level,': [6086], 'about': [6094], 'unclear': [6125], 'why': [6126], 'same': [6129], 'some': [6138], 'should': [6140, 6160], 'accelerated': [6162], 'states': [6187, 6197], 'somewhat': [6200], 'different.': [6201], 'Regarding': [6202], 'forming': [6216, 6224, 6290], 'non-adjacent': [6227], 'addition,': [6277], 'whether,': [6281], 'Although': [6297], 'α112′C': [6305], '8.7': [6307], 'range': [6311], 'ONE': [6321], 'saw': [6326], 'Negative': [6338], 'results': [6339], 'interpreted': [6342], 'care.': [6344], 'identifies': [6347], 'sulfur': [6354], 'atoms': [6355], 'collide': [6361], 'occur.': [6373], 'many': [6376], 'factors': [6377], 'prevent': [6380], 'colliding': [6385], 'appropriate': [6392], 'measurable': [6396], 'summary,': [6403], 'quite': [6431], 'dynamic.': [6432], 'appears': [6435], 'components.': [6442], 'movements': [6444], 'related': [6447], 'changes': [6451, 6534], 'well': [6469], 'cryoelectron': [6500], 'microscopic': [6501], 'Further': [6525], 'will': [6527], 'help': [6528], 'define': [6530], 'thank': [6542], 'Rachel': [6543], 'Berkowitz': [6544], 'technical': [6546], 'assistance': [6547], 'Moez': [6549], 'Bali,': [6550], 'Jeffrey': [6551], 'Horenstein,': [6552], 'Michaela': [6553], 'Jansen': [6554], 'David': [6555, 6559], 'Liebelt,': [6556], 'Nicole': [6557], 'McKinnon,': [6558], 'Reeves,': [6560], 'Paul': [6562], 'helpful': [6565], 'discussions': [6566], 'comments': [6570], 'manuscript.': [6573]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2011443142', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-11T19:12:04.568200', 'created_date': '2016-06-24'}
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