Publication Information

{'id': 'https://openalex.org/W2011437912', 'doi': 'https://doi.org/10.1152/japplphysiol.00793.2005', 'title': 'Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation', 'display_name': 'Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation', 'publication_year': 2006, 'publication_date': '2006-02-08', 'ids': {'openalex': 'https://openalex.org/W2011437912', 'doi': 'https://doi.org/10.1152/japplphysiol.00793.2005', 'mag': '2011437912', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16467393', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1363746'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/japplphysiol.00793.2005', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140889577', 'display_name': 'Journal of Applied Physiology', 'issn_l': '1522-1601', 'issn': ['1522-1601', '8750-7587'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320155', 'host_organization_name': 'American Physiological Society', 'host_organization_lineage': ['https://openalex.org/P4310320155'], 'host_organization_lineage_names': ['American Physiological Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc1363746?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5010883315', 'display_name': 'Charles W. Leffler', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I160606119', 'display_name': 'University of Tennessee Health Science Center', 'ror': 'https://ror.org/0011qv509', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I160606119']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Charles W. Leffler', 'raw_affiliation_strings': ['Dept. of Physiology, University of Tennessee Health Science Center, 894 Union Ave., Memphis, TN 38163, USA. [email protected]'], 'affiliations': [{'raw_affiliation_string': 'Dept. of Physiology, University of Tennessee Health Science Center, 894 Union Ave., Memphis, TN 38163, USA. [email protected]', 'institution_ids': ['https://openalex.org/I160606119']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051181120', 'display_name': 'Helena Parfenova', 'orcid': 'https://orcid.org/0000-0002-8623-8305'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Helena Parfenova', 'raw_affiliation_strings': ['Department of Physiology'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018134952', 'display_name': 'Jonathan H. Jaggar', 'orcid': 'https://orcid.org/0000-0003-1505-3335'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jonathan H. Jaggar', 'raw_affiliation_strings': ['Department of Physiology'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100431408', 'display_name': 'Rui Wang', 'orcid': 'https://orcid.org/0000-0003-3825-3620'}, 'institutions': [{'id': 'https://openalex.org/I72541430', 'display_name': 'Lakehead University', 'ror': 'https://ror.org/023p7mg82', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I72541430']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Rui Wang', 'raw_affiliation_strings': ['Lakehead University;'], 'affiliations': [{'raw_affiliation_string': 'Lakehead University;', 'institution_ids': ['https://openalex.org/I72541430']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.616, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 186, 'citation_normalized_percentile': {'value': 0.999677, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '100', 'issue': '3', 'first_page': '1065', 'last_page': '1076'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11848', 'display_name': 'Heme Oxygenase-1 and Carbon Monoxide', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11848', 'display_name': 'Heme Oxygenase-1 and Carbon Monoxide', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11456', 'display_name': 'Neuroscience of respiration and sleep', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11207', 'display_name': 'Alcohol Consumption and Health Effects', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cerebral-circulation', 'display_name': 'Cerebral circulation', 'score': 0.6237597}, {'id': 'https://openalex.org/keywords/second-messenger-system', 'display_name': 'Second messenger system', 'score': 0.5335038}, {'id': 'https://openalex.org/keywords/dilator', 'display_name': 'Dilator', 'score': 0.518049}], 'concepts': [{'id': 'https://openalex.org/C2779395532', 'wikidata': 'https://www.wikidata.org/wiki/Q7916469', 'display_name': 'Vascular smooth muscle', 'level': 3, 'score': 0.72009325}, {'id': 'https://openalex.org/C2779219270', 'wikidata': 'https://www.wikidata.org/wiki/Q419972', 'display_name': 'Heme oxygenase', 'level': 4, 'score': 0.6292886}, {'id': 'https://openalex.org/C119671327', 'wikidata': 'https://www.wikidata.org/wiki/Q886843', 'display_name': 'Cerebral circulation', 'level': 2, 'score': 0.6237597}, {'id': 'https://openalex.org/C120770815', 'wikidata': 'https://www.wikidata.org/wiki/Q14859627', 'display_name': 'Vasodilation', 'level': 2, 'score': 0.597964}, {'id': 'https://openalex.org/C2776217839', 'wikidata': 'https://www.wikidata.org/wiki/Q189621', 'display_name': 'Heme', 'level': 3, 'score': 0.5561738}, {'id': 'https://openalex.org/C163235415', 'wikidata': 'https://www.wikidata.org/wiki/Q899814', 'display_name': 'Second messenger system', 'level': 3, 'score': 0.5335038}, {'id': 'https://openalex.org/C2777032099', 'wikidata': 'https://www.wikidata.org/wiki/Q1225425', 'display_name': 'Dilator', 'level': 2, 'score': 0.518049}, {'id': 'https://openalex.org/C2779961880', 'wikidata': 'https://www.wikidata.org/wiki/Q1067506', 'display_name': 'Vasoconstriction', 'level': 2, 'score': 0.50800514}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.49345627}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4228714}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.40465564}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.39937282}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3668914}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.31962037}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.30581394}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.26240343}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.25764358}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.25706178}, {'id': 'https://openalex.org/C2992686903', 'wikidata': 'https://www.wikidata.org/wiki/Q208453', 'display_name': 'Smooth muscle', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002248', 'descriptor_name': 'Carbon Monoxide', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D002560', 'descriptor_name': 'Cerebrovascular Circulation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003542', 'descriptor_name': 'Cystathionine gamma-Lyase', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006419', 'descriptor_name': 'Heme Oxygenase (Decyclizing)', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006862', 'descriptor_name': 'Hydrogen Sulfide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014661', 'descriptor_name': 'Vasoconstriction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/japplphysiol.00793.2005', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140889577', 'display_name': 'Journal of Applied Physiology', 'issn_l': '1522-1601', 'issn': ['1522-1601', '8750-7587'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320155', 'host_organization_name': 'American Physiological Society', 'host_organization_lineage': ['https://openalex.org/P4310320155'], 'host_organization_lineage_names': ['American Physiological Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1363746', 'pdf_url': 'https://europepmc.org/articles/pmc1363746?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1363746', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16467393', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1363746', 'pdf_url': 'https://europepmc.org/articles/pmc1363746?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.79, 'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 169, 'referenced_works': ['https://openalex.org/W1485043634', 'https://openalex.org/W1489891513', 'https://openalex.org/W1529948332', 'https://openalex.org/W1535283961', 'https://openalex.org/W1545529843', 'https://openalex.org/W1566780076', 'https://openalex.org/W1572334445', 'https://openalex.org/W1587935192', 'https://openalex.org/W1636028712', 'https://openalex.org/W1766573027', 'https://openalex.org/W1775870515', 'https://openalex.org/W1807201726', 'https://openalex.org/W1821552521', 'https://openalex.org/W1884656506', 'https://openalex.org/W1903443535', 'https://openalex.org/W1919291000', 'https://openalex.org/W1940059160', 'https://openalex.org/W1941569159', 'https://openalex.org/W1964320031', 'https://openalex.org/W1966197860', 'https://openalex.org/W1966524610', 'https://openalex.org/W1968315878', 'https://openalex.org/W1971953739', 'https://openalex.org/W1972559451', 'https://openalex.org/W1972605328', 'https://openalex.org/W1974037978', 'https://openalex.org/W1974576562', 'https://openalex.org/W1975072795', 'https://openalex.org/W1975399959', 'https://openalex.org/W1976320302', 'https://openalex.org/W1976599798', 'https://openalex.org/W1978098707', 'https://openalex.org/W1978506358', 'https://openalex.org/W1979813261', 'https://openalex.org/W1985802011', 'https://openalex.org/W1994470095', 'https://openalex.org/W1995117391', 'https://openalex.org/W1996175812', 'https://openalex.org/W1998084962', 'https://openalex.org/W1999493192', 'https://openalex.org/W1999554896', 'https://openalex.org/W1999872183', 'https://openalex.org/W2001323948', 'https://openalex.org/W2001327738', 'https://openalex.org/W2007954089', 'https://openalex.org/W2008162612', 'https://openalex.org/W2010389170', 'https://openalex.org/W2014521862', 'https://openalex.org/W2015407072', 'https://openalex.org/W2017715658', 'https://openalex.org/W2020592563', 'https://openalex.org/W2021914074', 'https://openalex.org/W2022496784', 'https://openalex.org/W2023328430', 'https://openalex.org/W2025623081', 'https://openalex.org/W2026651523', 'https://openalex.org/W2027049227', 'https://openalex.org/W2028516053', 'https://openalex.org/W2029326990', 'https://openalex.org/W2030365747', 'https://openalex.org/W2034255062', 'https://openalex.org/W2036385397', 'https://openalex.org/W2037527680', 'https://openalex.org/W2038796859', 'https://openalex.org/W2039912038', 'https://openalex.org/W2039987293', 'https://openalex.org/W2040490831', 'https://openalex.org/W2040755930', 'https://openalex.org/W2040758797', 'https://openalex.org/W2043123847', 'https://openalex.org/W2043741726', 'https://openalex.org/W2044196027', 'https://openalex.org/W2044615514', 'https://openalex.org/W2047135131', 'https://openalex.org/W2051245656', 'https://openalex.org/W2052374786', 'https://openalex.org/W2054802842', 'https://openalex.org/W2054807014', 'https://openalex.org/W2056523101', 'https://openalex.org/W2056873153', 'https://openalex.org/W2056881064', 'https://openalex.org/W2058418399', 'https://openalex.org/W2061228574', 'https://openalex.org/W2061545526', 'https://openalex.org/W2063935857', 'https://openalex.org/W2065527303', 'https://openalex.org/W2066783947', 'https://openalex.org/W2067107703', 'https://openalex.org/W2068687524', 'https://openalex.org/W2069071523', 'https://openalex.org/W2069838690', 'https://openalex.org/W2072474837', 'https://openalex.org/W2074253297', 'https://openalex.org/W2074857962', 'https://openalex.org/W2075610315', 'https://openalex.org/W2075984518', 'https://openalex.org/W2077574201', 'https://openalex.org/W2079594720', 'https://openalex.org/W2081141077', 'https://openalex.org/W2081635255', 'https://openalex.org/W2083916670', 'https://openalex.org/W2084137910', 'https://openalex.org/W2087311397', 'https://openalex.org/W2087516645', 'https://openalex.org/W2089836114', 'https://openalex.org/W2093205075', 'https://openalex.org/W2097346090', 'https://openalex.org/W2097708842', 'https://openalex.org/W2097871217', 'https://openalex.org/W2098147784', 'https://openalex.org/W2105482032', 'https://openalex.org/W2108463035', 'https://openalex.org/W2109042906', 'https://openalex.org/W2110711862', 'https://openalex.org/W2110715023', 'https://openalex.org/W2110730658', 'https://openalex.org/W2110795253', 'https://openalex.org/W2111967645', 'https://openalex.org/W2112107066', 'https://openalex.org/W2117310938', 'https://openalex.org/W2117654405', 'https://openalex.org/W2120529833', 'https://openalex.org/W2121153005', 'https://openalex.org/W2121293450', 'https://openalex.org/W2122702212', 'https://openalex.org/W2123766048', 'https://openalex.org/W2124174923', 'https://openalex.org/W2128764672', 'https://openalex.org/W2131173683', 'https://openalex.org/W2131276542', 'https://openalex.org/W2133365493', 'https://openalex.org/W2136344232', 'https://openalex.org/W2139866039', 'https://openalex.org/W2140878835', 'https://openalex.org/W2141610173', 'https://openalex.org/W2142774022', 'https://openalex.org/W2144529731', 'https://openalex.org/W2145530136', 'https://openalex.org/W2146883699', 'https://openalex.org/W2147804877', 'https://openalex.org/W2149749705', 'https://openalex.org/W2153674482', 'https://openalex.org/W2155217757', 'https://openalex.org/W2156726790', 'https://openalex.org/W2159558963', 'https://openalex.org/W2166085728', 'https://openalex.org/W2166803343', 'https://openalex.org/W2166811447', 'https://openalex.org/W2168559229', 'https://openalex.org/W2169037315', 'https://openalex.org/W2169075889', 'https://openalex.org/W2170431734', 'https://openalex.org/W2178628225', 'https://openalex.org/W2240089866', 'https://openalex.org/W2274482651', 'https://openalex.org/W2327792810', 'https://openalex.org/W2330224437', 'https://openalex.org/W2336678639', 'https://openalex.org/W2423788073', 'https://openalex.org/W285469281', 'https://openalex.org/W29430268', 'https://openalex.org/W304581165', 'https://openalex.org/W36734567', 'https://openalex.org/W4206561406', 'https://openalex.org/W4241123725', 'https://openalex.org/W4248533072', 'https://openalex.org/W4249844052', 'https://openalex.org/W56764977', 'https://openalex.org/W59004714'], 'related_works': ['https://openalex.org/W4231569049', 'https://openalex.org/W2460646035', 'https://openalex.org/W2410519466', 'https://openalex.org/W2399218979', 'https://openalex.org/W2397739911', 'https://openalex.org/W2376702201', 'https://openalex.org/W2030659467', 'https://openalex.org/W2019257926', 'https://openalex.org/W2017140251', 'https://openalex.org/W1441864865'], 'abstract_inverted_index': {'This': [0, 91], 'review': [1], 'focuses': [2], 'on': [3, 139], 'two': [4], 'gaseous': [5], 'cellular': [6], 'messenger': [7], 'molecules,': [8], 'CO': [9, 21, 59, 73, 127, 207], 'and': [10, 32, 53, 70, 136, 200, 208, 215, 224, 235, 245, 249], 'H': [11, 141, 168, 190, 209], '2': [12, 142, 169, 191, 210, 226, 251], 'S,': [13], 'that': [14, 80, 98], 'are': [15], 'involved': [16], 'in': [17, 26, 50, 154, 237, 253], 'cerebrovascular': [18, 149], 'flow': [19], 'regulation.': [20], 'is': [22, 36, 61, 81, 152], 'a': [23, 41, 148], 'dilatory': [24], 'mediator': [25], 'active': [27], 'hyperemia,': [28], 'autoregulation,': [29], 'hypoxic': [30], 'dilation,': [31], 'counteracting': [33], 'vasoconstriction.': [34], 'It': [35, 151], 'produced': [37, 153], 'from': [38], 'heme': [39, 79], 'by': [40, 54, 63, 76, 159, 164], 'constitutively': [42], 'expressed': [43, 48], 'enzyme': [44, 57], '[heme': [45], 'oxygenase': [46], '(HO)-2]': [47], 'highly': [49], 'the': [51, 117, 213, 216, 222, 238, 243, 254], 'brain': [52], 'an': [55], 'inducible': [56], '(HO-1).': [58], 'production': [60], 'regulated': [62], 'controlling': [64], 'substrate': [65], 'availability,': [66], 'HO-2': [67], 'catalytic': [68], 'activity,': [69], 'HO-1': [71], 'expression.': [72], 'dilates': [74, 171], 'arterioles': [75, 172], 'binding': [77, 92], 'to': [78, 83, 105, 123, 186, 231], 'bound': [82], 'large-conductance': [84, 106], 'Ca': [85, 95, 102, 107], '2+': [86, 96, 103, 108], '-activated': [87, 109], 'K': [88, 110, 181], '+': [89, 111, 182], 'channels.': [90, 183], 'elevates': [93], 'channel': [94, 112], 'sensitivity,': [97], 'increases': [99], 'coupling': [100], 'of': [101, 161, 179, 195, 218, 242, 247], 'sparks': [104], 'openings': [113], 'and,': [114], 'thereby,': [115], 'hyperpolarizes': [116], 'vascular': [118, 133, 155, 196, 203], 'smooth': [119, 156, 197], 'muscle.': [120], 'In': [121, 184], 'addition': [122, 185], 'dilating': [124, 187], 'blood': [125, 188], 'vessels,': [126, 189], 'can': [128], 'either': [129], 'inhibit': [130], 'or': [131], 'accentuate': [132], 'cell': [134], 'proliferation': [135], 'apoptosis,': [137], 'depending': [138], 'conditions.': [140], 'S': [143, 170, 192, 211, 227, 252], 'may': [144], 'also': [145], 'function': [146, 214], 'as': [147], 'dilator.': [150], 'muscle': [157, 198], 'cells': [158, 199], 'hydrolysis': [160], 'l-cysteine': [162], 'catalyzed': [163], 'cystathione': [165], 'γ-lyase': [166], '(CSE).': [167], 'at': [173], 'physiologically': [174], 'relevant': [175], 'concentrations': [176], 'via': [177], 'activation': [178], 'ATP-sensitive': [180], 'promotes': [193], 'apoptosis': [194], 'inhibits': [201], 'proliferation-associated': [202], 'remodeling.': [204], 'Thus': [205], 'both': [206], 'modulate': [212], 'structure': [217], 'circulatory': [219], 'system.': [220], 'Both': [221], 'HO-CO': [223, 248], 'CSE-H': [225, 250], 'systems': [228], 'have': [229], 'potential': [230], 'interact': [232], 'with': [233], 'NO': [234], 'prostanoids': [236], 'cerebral': [239, 255], 'circulation.': [240], 'Much': [241], 'physiology': [244], 'biochemistry': [246], 'circulation': [256], 'remains': [257], 'open': [258], 'for': [259], 'exploration.': [260]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2011437912', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 12}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 17}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 13}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2024-12-07T23:39:11.796969', 'created_date': '2016-06-24'}