Title: Effect of protein-energy wasting (PEW) on muscle protein metabolism and oxygen consumption in patients with end-stage renal disease (ESRD)
Abstract: PEW is associated with muscle dysfunction and excess mortality in ESRD patients. However the mechanisms causing wasting have been scarcely studied in humans. In addition, to what extent the microinflammatory state associated with uremia affects the individual determinants of protein turnover has not been specifically studied so far. In the present study, we measured protein synthesis (PS) and degradation (PD) (2H-phe kinetics) and oxygen (O2) uptake across the forearm in 58 subjects. Forearm protein turnover was studied in patients with CKD stage IV (n=16-unresticted diet- and n= 13 under low protein diets), in hemodialysis-treated patients with ESRD (n=17, of whom 10 were protein-calorie wasted), and in 12 controls (C). Amino acids were determined by an amino acid analyzer, while phenylalanine isotopic enrichments by GC/MS. Blood flow across the forearm was determined by strain-gauge plethysmography. Data are given in nmol/min. 100 ml forearm.
Publication Year: 2013
Publication Date: 2013-12-01
Language: en
Type: article
Indexed In: ['crossref']
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