Publication Information

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1982, 2056, 2187, 2610, 2643, 2687, 2827, 2852, 2858, 2906, 2920, 2982, 3043, 3049, 3147, 3220, 3228, 3496, 3511, 3570, 3666, 3692, 3820, 3833, 3879, 3914, 3985, 4041, 4051, 4060, 4067, 4135, 4156, 4162, 4175, 4182, 4205, 4221, 4228], 'maintain': [10, 173, 3932], 'the': [11, 21, 77, 84, 119, 124, 174, 184, 240, 247, 282, 287, 349, 352, 559, 578, 587, 594, 815, 819, 871, 977, 982, 994, 1025, 1076, 1080, 1089, 1218, 1445, 1879, 1932, 1954, 1968, 1976, 2007, 2034, 2066, 2080, 2113, 2188, 2412, 2644, 2670, 2688, 2696, 2742, 2748, 2758, 2761, 2779, 2782, 2838, 2936, 2964, 2967, 2986, 2997, 3016, 3112, 3133, 3200, 3222, 3236, 3331, 3350, 3410, 3449, 3472, 3717, 3777, 3793, 3805, 3821, 3841, 3851, 4006, 4044, 4055, 4071, 4091, 4144, 4147, 4176, 4196, 4206, 4222, 4248, 4305], 'survival': [12, 78, 154, 175, 241, 317, 614, 1452, 1467, 1499], 'of': [13, 24, 54, 79, 86, 106, 114, 118, 132, 176, 187, 217, 242, 249, 269, 277, 281, 295, 327, 351, 392, 477, 562, 582, 596, 650, 670, 821, 976, 1029, 1055, 1082, 1091, 1094, 1099, 1221, 1280, 1314, 1639, 2060, 2094, 2105, 2356, 2379, 2411, 2431, 2441, 2465, 2580, 2606, 2623, 2754, 2757, 2768, 2788, 2952, 2990, 3058, 3224, 3226, 3335, 3349, 3355, 3378, 3425, 3485, 3566, 3576, 3630, 3713, 3719, 3770, 3779, 3787, 3795, 3798, 3825, 3856, 3894, 4026, 4029, 4073, 4093, 4097, 4146, 4179, 4211, 4225, 4251, 4307, 4317], 'non-small': [14, 177, 378, 463, 654], 'cell': [15, 134, 153, 178, 297, 316, 379, 464, 655, 1351, 1451, 1466, 1498, 1512, 1963, 2115, 2654, 3843, 3933, 3963, 4057, 4149, 4314], 'lung': [16, 179, 380, 465, 656], 'cancer': [17, 180, 657], '(NSCLC)': [18, 181], 'cells,': [19, 60, 182, 223, 3595, 4244], 'but': [20, 183, 814, 3632, 3889, 3973], 'biochemical': [22, 185], 'basis': [23, 186], 'this': [25, 188, 1459, 2994, 3013], 'phenomenon': [26, 189], 'has': [27, 190, 3276], 'not': [28, 191, 827, 1454, 3633, 3959, 3974, 4001, 4013], 'been': [29, 192, 828, 1455, 3277], 'elucidated.': [30, 193], 'Here': [31, 194], 'we': [32, 195, 1461, 1474, 3192, 3271, 3702, 3808, 3940, 4089, 4245, 4254], 'used': [33, 196, 357, 442, 2874, 2905, 2919, 2944, 2981, 2999, 3020, 3193, 3219, 3272, 3404], 'genetic': [34, 197, 660, 831, 1478], 'approaches': [35, 198, 1479], 'modulate': [37, 200, 1481], 'MKK4': [38, 75, 96, 108, 151, 201, 238, 259, 271, 314, 1266, 1315, 1449, 1464, 1482, 1496, 1823, 1842, 1856, 3492, 3567, 3598, 3672, 3705, 3895, 3901, 4063, 4075, 4081, 4099, 4120, 4165, 4231, 4252], 'expression': [39, 85, 202, 248, 783, 823, 883, 1081, 1483, 1701, 2833, 3732, 3749, 3822, 3885, 3910, 3957, 4048, 4076, 4153, 4173, 4219], 'in': [40, 203, 593, 612, 647, 664, 675, 787, 824, 837, 947, 1024, 1088, 1124, 1210, 1484, 1534, 1591, 1891, 1950, 2065, 2098, 2194, 2289, 2353, 2385, 2462, 2479, 2496, 2577, 2653, 2680, 2800, 2837, 2844, 2894, 2966, 2985, 3037, 3235, 3248, 3457, 3590, 3759, 3831, 3840, 3869, 3874, 3883, 3886, 3908, 3923, 3935, 3950, 3961, 3970, 3975, 4054, 4101, 4122, 4151, 4164, 4189, 4236, 4242, 4257], 'mouse': [41, 204, 383, 468, 1485, 1675, 3411], 'embryo': [42, 205, 384, 469, 1486], 'fibroblasts': [43, 206, 1487], '(MEF': [44, 207, 1488], 'cells)': [45, 208, 1489], 'and': [46, 88, 116, 209, 251, 279, 335, 525, 567, 572, 575, 603, 615, 672, 981, 987, 997, 1031, 1060, 1062, 1067, 1078, 1097, 1213, 1348, 1490, 1509, 1522, 1531, 1546, 1616, 1645, 1650, 1669, 1674, 1681, 1765, 1811, 1847, 1860, 1881, 1886, 1948, 2038, 2072, 2119, 2192, 2351, 2394, 2424, 2453, 2468, 2557, 2603, 2615, 2674, 2809, 2815, 2856, 2885, 2902, 2913, 2916, 2938, 2957, 3004, 3010, 3041, 3052, 3105, 3136, 3140, 3257, 3353, 3389, 3395, 3406, 3420, 3459, 3478, 3582, 3592, 3677, 3735, 3751, 3753, 3761, 3812, 3823, 3850, 3853, 3911, 4017, 4049, 4078, 4110, 4115, 4132, 4154, 4158, 4208, 4321], 'NSCLC': [47, 133, 210, 296, 665, 788, 825, 838, 948, 1120, 1211, 1491, 1511, 4237, 4258, 4313], 'cells': [48, 63, 81, 211, 226, 244, 1121, 1212, 1281, 1549, 1923, 1986, 2024, 2086, 2107, 2797, 3503, 3510, 3635, 3641, 3658, 3665, 3684, 3691, 3728, 3744, 3763, 3815, 3872, 3888, 3897, 3972, 3977, 3997, 4069, 4083, 4103, 4125, 4181, 4192, 4204, 4227, 4259], 'identify': [50, 213], 'prosurvival': [51, 214, 1208, 1311, 4249], 'signals': [52, 215, 1209], 'downstream': [53, 216, 3796, 3827], 'MKK4.': [55, 218, 4098], 'Relative': [56, 219, 2736], 'wild-type': [58, 221, 1547, 1984, 3508, 3593, 3634, 3663, 3689, 3742, 3762, 3813, 3875, 3896, 3971, 4082, 4123, 4190], 'MEF': [59, 62, 80, 222, 225, 243, 1548, 1985, 3502, 3509, 3594, 3657, 3664, 3683, 3690, 3727, 3743, 3814, 3871, 3952, 4124, 4180, 4191, 4243], 'MKK4-null': [61, 224, 1545, 3501, 3591, 3631, 3656, 3682, 3726, 3760, 3811, 3870, 3887, 3925, 3951, 3976, 4068, 4102, 4226], 'were': [64, 227, 1524, 1532, 1589, 1754, 1826, 1851, 1867, 1889, 1924, 1942, 1979, 1992, 2025, 2063, 2096, 2108, 2174, 2198, 2286, 2436, 2460, 2494, 2527, 2574, 2601, 2608, 2678, 2798, 2830, 2842, 2904, 2918, 2943, 3015, 3054, 3067, 3103, 3109, 3126, 3144, 3240, 3403, 3430, 3455, 3489, 3588, 3642, 3659, 3685, 3757, 3838, 3866, 3998, 4160, 4199], 'highly': [65, 228], 'susceptible': [66, 229, 3687], 'apoptosis': [68, 231, 1123, 1352, 1640, 1906, 3512, 3583, 3629, 3668, 4007, 4052, 4112], 'by': [69, 82, 100, 155, 232, 245, 263, 318, 553, 887, 1027, 1037, 1047, 1275, 1447, 1476, 1500, 1705, 1768, 1814, 1873, 1967, 1999, 2018, 2281, 2407, 2427, 2438, 2455, 2489, 2669, 2729, 2747, 2862, 3056, 3330, 3362, 3514, 3645, 4009, 4037, 4070, 4113, 4193], 'LY294002,': [70, 233, 3515, 3698], 'paclitaxel,': [71, 234], 'or': [72, 235, 878, 1040, 1289, 1900, 1929, 1941, 1987, 2017, 2027, 2031, 2089, 2701, 3129, 3344, 3487, 3623, 3723, 3830, 4139, 4325], 'serum': [73, 236, 1543, 3624, 3927, 3943, 3965, 3989, 4010], 'starvation.': [74, 237], 'promoted': [76, 239], 'decreasing': [83, 246], 'phosphatase': [87, 250, 346, 2634, 3737], 'tensin': [89, 252, 336], 'homologue': [90, 253, 337], 'deleted': [91, 254, 338], 'from': [92, 255, 339, 993, 1217, 1526, 1690, 1829, 3061, 3199, 3242, 3451, 3474, 4024, 4080], 'chromosome': [93, 256, 340], '10': [94, 257, 2399, 2409, 2569], '(PTEN).': [95, 258], 'inhibited': [97, 260], 'PTEN': [98, 143, 261, 306, 333, 781, 822, 830, 874, 882, 1646, 1750, 2491, 2517, 2633, 2702, 2759, 2769, 2780, 2789, 2839, 2991, 3053, 3102, 3237, 3412, 3479, 3675, 3731, 3782, 3884, 3909, 3956, 4030, 4047, 4108, 4130, 4152, 4172, 4185, 4197, 4218, 4308], 'transcription': [99, 262, 941], 'activating': [101, 156, 264, 319, 673, 1501], 'NFκB,': [102, 265], 'a': [103, 130, 137, 266, 293, 300, 343, 609, 648, 834, 939, 1051, 1063, 1199, 1268, 1310, 1688, 1827, 2057, 2075, 2092, 2177, 2521, 2639, 2657, 2709, 2730, 2869, 2908, 2922, 2946, 2949, 3148, 3194, 3269, 3323, 3422, 3434, 3516, 3710, 3880, 3917, 4021, 4033, 4087, 4095, 4233], 'transcriptional': [104, 267], 'suppressor': [105, 268], 'PTEN.': [107, 270, 3780], 'was': [109, 145, 272, 308, 1687, 1703, 1766, 1812, 1871, 1965, 1997, 2053, 2124, 2279, 2383, 2405, 2425, 2448, 2487, 2518, 2636, 2651, 2706, 2723, 2739, 2772, 2792, 2818, 2821, 2971, 2980, 3031, 3218, 3320, 3359, 3366, 3446, 3469, 3773, 3903, 4064, 4186], 'required': [110, 273, 3791], 'for': [111, 274, 1897, 1905, 1935, 1953, 2033, 2047, 2398, 2418, 2593, 2630, 2695, 2832, 2948, 3012, 3021, 3070, 3101, 3132, 3372, 3381, 3386, 3392, 3399, 3792], 'nuclear': [112, 275, 3141], 'translocation': [113, 276], 'RelA/p65': [115, 278, 980], 'processing': [117, 280], 'NFκB2': [120, 283], 'precursor': [121, 284], '(p100)': [122, 285], 'into': [123, 286, 1075, 1876, 2812, 2973, 3138], 'mature': [125, 288], 'form': [126, 289], '(p52).': [127, 290], 'Studies': [128, 291], 'on': [129, 292, 565, 2112, 2396, 2470, 2778, 3033, 3433, 3448, 3471, 3604, 3637, 3804, 4239], 'panel': [131, 294], 'lines': [135, 298, 1513, 4150], 'revealed': [136, 299, 3654], 'subset': [138, 301], 'high': [140, 303, 3983, 4171, 4217], 'MKK4/high': [141, 304], 'NFκB/low': [142, 305], 'that': [144, 307, 347, 873, 943, 1198, 1272, 1463, 1495, 3249, 3408, 3500, 3597, 3655, 3681, 3704, 3767, 3810, 3893, 3931, 3942, 4005, 4025, 4046, 4216, 4247, 4253], 'relatively': [146, 309], 'resistant': [147, 310], 'apoptosis.': [149, 312, 4183], 'Thus,': [150, 313, 3900, 4143], 'promotes': [152, 315, 1465, 1497], 'through': [159, 322, 892, 1468, 1503, 3937, 4020, 4304], 'an': [160, 323, 590, 1504, 2717, 3620, 3906, 4074], 'NFκB/PTEN-dependent': [161, 324, 1505], 'pathway.': [162, 325, 1506], 'Regulation': [326], 'phosphoinositides': [328, 353], 'is': [329, 342, 644, 784, 833, 875, 884, 944, 1022, 1045, 1267, 1273, 3619, 3790, 4302], 'important': [330], 'tumorigenesis.': [332], '(phosphatase': [334], '10)': [341], 'dual': [344, 1269, 2731], 'specificity': [345, 1270, 3223], 'dephosphorylates': [348], '3′-sites': [350], 'PI(3,4)P2': [354, 571, 576], '2The': [355, 440], 'abbreviations': [356, 441], 'are:': [358, 443], 'PI(3,4)P2,': [359, 444], '3,4-bisphosphate;': [361, 446], 'PI(3,4,5)P3,': [362, 447], '3,4,5-trisphosphate;': [364, 415, 449, 500], 'PI(4)P,': [365, 450], '4-monophosphate;': [367, 373, 452, 458], 'PI(4,5)P2,': [368, 453], '4,5-bisphosphate;': [370, 455], 'PI,': [371, 456], 'l-α-phosphatidylinositol': [372, 457, 1613], 'PI3K,': [374, 459, 667, 3701, 3799], '3-kinase;': [376, 461], 'NSCLC,': [377, 462], 'cancer;': [381, 466], 'MEF,': [382, 467], 'fibroblasts;': [385, 470], 'TNF,': [386, 471], 'tumor': [387, 472, 651, 888, 1095], 'necrosis': [388, 473, 889], 'factor;': [389, 474], 'IκB,': [390, 475], 'inhibitor': [391, 476, 1028, 1638, 3518], 'NFκB;': [393, 478], 'IKK,': [394, 479], 'IκB': [395, 480, 1044, 1048, 1670], 'kinase;': [396, 405, 481, 490], 'MKK4,': [397, 482, 1668], 'mitogen-activated': [398, 483, 1202], 'kinase-4;': [401, 486], 'JNK,': [402, 487, 4094], 'c-Jun': [403, 488], 'N-terminal': [404, 489], 'shRNA,': [406, 491], 'short': [407, 492, 1843], 'hairpin': [408, 493, 1844], 'RNA;': [409, 494], 'MTT,': [410, 495], '3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium': [411, 496, 1969], 'bromide;': [412, 497], 'PIP3,': [413, 498, 3788], 'inositol': [414, 499], 'MOPS,': [416, 501], '4-morpholinepropanesulfonic': [417, 502], 'acid;': [418, 503], 'EMSA,': [419, 504], 'electrophoretic': [420, 505], 'mobility': [421, 506], 'shift': [422, 507], 'assay;': [423, 508], 'ChIP,': [424, 509], 'chromatin': [425, 510], 'immunoprecipitation;': [426, 511], 'GST,': [427, 512], 'glutathione': [428, 513], 'S-transferase;': [429, 514], 'RNAi,': [430, 515], 'RNA': [431, 516, 1845, 1859, 1865, 3028], 'interference;': [432, 517], 'p-,': [433, 518], 'phosphorylated;': [434, 519], 'EV,': [435, 520], 'empty': [436, 521, 1988], 'vector;': [437, 522], 'Scr,': [438, 523], 'scrambled.': [439, 524], 'PI(3,4,5)P3': [526, 548, 574], '(1Maehama': [527], 'T.': [528, 1172, 1243, 1362, 1378, 1380, 1393, 1411, 1417, 1421, 1427, 1435, 1559, 1575, 1577, 2148, 2222, 3084, 3088, 3538, 4279], 'Dixon': [529], 'J.E.': [530], 'J.': [531, 626, 734, 771, 790, 794, 802, 899, 906, 950, 954, 962, 1107, 1179, 1250, 1328, 1403, 1413, 1725, 2155, 2229, 2254, 2259, 3163, 3291, 3545, 4286], 'Biol.': [532, 633, 907, 930, 1144, 1180, 1251, 1437, 2156, 2230, 2260, 3546, 4287], 'Chem.': [533, 908, 1181, 1252, 2157, 2231, 2261, 3547, 4288], '1998;': [534, 862], '273:': [535], '13375-13378Abstract': [536], 'Full': [537, 539, 912, 914, 1008, 1010, 1185, 1187, 1256, 1258, 1298, 1300, 1739, 1741, 2161, 2163, 2235, 2237, 2265, 2267, 3177, 3179, 3305, 3307, 3551, 3553, 4292, 4294], 'Text': [538, 540, 913, 915, 1009, 1011, 1186, 1188, 1257, 1259, 1299, 1301, 1740, 1742, 2162, 2164, 2236, 2238, 2266, 2268, 3178, 3180, 3306, 3308, 3552, 3554, 4293, 4295], 'PDF': [541, 916, 1012, 1189, 1260, 1302, 1743, 2165, 2239, 2269, 3181, 3309, 3555, 4296], 'PubMed': [542, 637, 759, 776, 809, 865, 917, 934, 969, 1013, 1115, 1148, 1190, 1261, 1303, 1343, 1389, 1441, 1586, 1744, 1794, 2166, 2240, 2270, 3182, 3310, 3556, 4297], 'Scopus': [543, 638, 760, 777, 810, 866, 918, 935, 970, 1014, 1116, 1149, 1191, 1262, 1304, 1344, 1745, 1795, 2167, 2241, 2271, 3183, 3311, 3557, 4298], '(2552)': [544], 'Google': [545, 640, 710, 723, 762, 779, 812, 868, 920, 937, 972, 1016, 1118, 1151, 1193, 1264, 1306, 1346, 1390, 1442, 1587, 1747, 1797, 2169, 2243, 2273, 3097, 3185, 3313, 3559, 4300], 'Scholar).': [546, 641, 780, 973, 1017, 1119, 1194, 1265, 1307, 1443, 1748, 1798, 2170, 2274, 3098, 3186, 3314, 3560], 'Endogenous': [547], 'levels': [549, 3786, 3837, 3847], 'are': [550, 991, 2892, 3504], 'also': [551, 3643], 'regulated': [552], '(PI3K),': [556], 'which': [557, 607, 990, 1448, 1473, 1991, 2712, 3275, 3454, 3618, 3653, 3699, 3789, 3994, 4318], 'phosphorylates': [558], 'D3': [560], 'position': [561], '(PI)': [564], 'PI(4)P': [566], 'PI(4,5)P2': [568], 'produce': [570], 'PI(3,4,5)P3.': [573], 'recruit': [577], 'pleckstrin': [579], 'homology': [580], 'domains': [581], 'specific': [583], 'intracellular': [584, 3785], 'proteins': [585], 'plasma': [588], 'membrane,': [589], 'essential': [591], 'event': [592, 836], 'activation': [595, 1098, 3794], 'PI3K-dependent': [597, 642, 1471, 3679, 3708, 3771], 'kinases': [598], 'such': [599, 3800], 'as': [600, 2126, 2200, 2667, 2716, 2741, 2865, 2898, 2945, 3018, 3328, 3367, 3801, 3862], 'phosphoinositide-dependent': [601], 'kinase-1': [602], 'B/AKT,': [606], 'have': [608, 826, 1453], 'key': [610, 1086, 3711], 'role': [611], 'cellular': [613, 3063, 3714], 'transformation': [616], '(2Katso': [617], 'R.': [618, 765, 854, 1133, 1162, 1164, 1233, 1235, 2138, 2140, 2212, 2214, 2252, 3528, 3530, 4269, 4271], 'Okkenhaug': [619], 'K.': [620, 622, 690, 846, 1174, 1245, 1368, 1395, 1565, 2150, 2224, 3540, 4281], 'Ahmadi': [621], 'White': [623], 'S.': [624, 713, 736, 748, 848, 852, 895, 925, 1001, 1338, 1397, 1405, 1723, 2250, 3161, 3289], 'Timms': [625], 'Waterfield': [627], 'M.D.': [628], 'Annu.': [629], 'Rev.': [630], 'Cell': [631, 1507, 1529, 1884, 2672], 'Dev.': [632, 1436], '2001;': [634], '17:': [635, 863], '615-675Crossref': [636], '(971)': [639], 'signaling': [643, 3772], 'frequently': [645, 785], 'activated': [646, 946, 1274], 'variety': [649], 'types,': [652, 3844], 'including': [653, 668, 1278, 3695], '(NSCLC).': [658], 'Several': [659], 'events': [661], 'previously': [662, 1196, 2128, 2202, 3069, 3151, 3279, 3499, 4256], 'described': [663, 2127, 2201, 3068, 3150, 3278], 'activate': [666], 'amplification': [669], 'PIK3CA': [671], 'mutations': [674, 2965, 2984], 'PIK3CA,': [676], 'EGFR,or': [677], 'K-RAS': [678], '(3Massion': [679], 'P.P.': [680], 'Kuo': [681], 'W.L.': [682], 'Stokoe': [683], 'D.': [684, 694, 698, 1105, 1141, 1158, 1229, 1320, 1399, 1695, 1710, 1773, 1780, 1834, 2134, 2208, 2958, 3524, 4265], 'Olshen': [685], 'A.B.': [686], 'Treseler': [687], 'P.A.': [688, 804, 964], 'Chin': [689], 'Chen': [691], 'C.': [692, 798, 897, 958, 1166, 1237, 1322, 1356, 1370, 1372, 1553, 1567, 1569, 1715, 2142, 2216, 3153, 3281, 3532, 4273], 'Polikoff': [693], 'Jain': [695], 'A.N.': [696], 'Pinkel': [697], 'Albertson': [699], 'D.G.': [700], 'Jablons': [701], 'D.M.': [702], 'Gray': [703], 'J.W.': [704], 'Cancer': [705, 1697, 1712, 1775, 1836, 3092], 'Res.': [706, 1789, 3093], '2002;': [707, 1005, 1438, 1791, 3094], '62:': [708], '3636-3640PubMed': [709], 'Scholar,': [711, 724, 763, 921, 1152, 1391, 2244], '4Ohshima': [712], 'Shimizu': [714, 1406], 'Y.': [715, 726, 844, 1160, 1231, 1425, 2136, 2210, 2248, 3526, 4267], 'Takahama': [716], 'M.': [717, 1003, 1135, 1324, 1360, 1419, 1423, 1557, 1727, 3165, 3293], 'Virchows': [718, 1110], 'Arch.': [719, 1111], '1994;': [720], '424:': [721], '129-134PubMed': [722], '5Samuels': [725], 'Wang': [727], 'Z.': [728, 1719, 3157, 3285], 'Bardelli': [729], 'A.': [730, 740, 856, 1339], 'Silliman': [731], 'N.': [732, 1407], 'Ptak': [733], 'Szabo': [735], 'Yan': [737], 'H.': [738, 1156, 1227, 1354, 1376, 1409, 1415, 1433, 1551, 1573, 2132, 2206, 3522, 4263], 'Gazdar': [739, 857], 'Powell': [741], 'S.M.': [742], 'Riggins': [743], 'G.J.': [744], 'Willson': [745], 'J.K.': [746], 'Markowitz': [747], 'Kinzler': [749], 'K.W.': [750], 'Vogelstein': [751], 'B.': [752, 1717, 2246, 3155, 3283], 'Velculescu': [753], 'V.E.': [754], 'Science.': [755, 772], '2004;': [756, 773, 909, 931], '304:': [757], '554Crossref': [758], '(2852)': [761], '6Sordella': [764], 'Bell': [766], 'D.W.': [767], 'Haber': [768], 'D.A.': [769], 'Settleman': [770], '305:': [774], '1163-1167Crossref': [775], '(1464)': [778], 'gene': [782, 2698, 2840, 3476], 'silenced': [786, 876], '(7Tsurutani': [789, 949], 'Castillo': [791, 951], 'S.S.': [792, 952], 'Brognard': [793, 953], 'Granville': [795, 955], 'C.A.': [796, 956], 'Zhang': [797, 957, 2253], 'Gills': [799, 959], 'J.J.': [800, 960], 'Sayyah': [801, 961], 'Dennis': [803, 963], 'Carcinogenesis.': [805, 965], '2005;': [806, 966, 1112], '26:': [807, 967], '1182-1195Crossref': [808, 968], '(257)': [811, 971], 'Scholar),': [813, 869, 938], 'mechanisms': [816, 1446], 'contributing': [817], 'loss': [820, 3565, 3599, 3706, 3902], 'defined.': [829, 1457], 'deletion': [832], 'rare': [835], '(8Forgacs': [839], 'E.': [840], 'Biesterveld': [841], 'E.J.': [842], 'Sekido': [843], 'Fong': [845], 'Muneer': [847], 'Wistuba': [849], 'I.I.': [850], 'Milchgrub': [851], 'Brezinschek': [853], 'Virmani': [855], 'A.F.': [858], 'Minna': [859], 'J.D.': [860], 'Oncogene.': [861], '1557-1565Crossref': [864], '(183)': [867], 'raising': [870], 'possibility': [872, 4045], 'transcriptionally': [877, 885, 1033], 'post-transcriptionally.': [879], 'Of': [880], 'note,': [881], 'suppressed': [886], 'factor-α': [890], '(TNFα)': [891], 'NFκB': [893, 974, 1021, 1073, 2846, 3189, 3210, 3227, 3232, 3245, 3417], '(9Kim': [894], 'Domon-Dell': [896], 'Kang': [898], 'Chung': [900], 'D.H.': [901], 'Freund': [902], 'J.N.': [903], 'Evers': [904], 'B.M.': [905], '279:': [910], '4285-4291Abstract': [911], '(92)': [919], '10Vasudevan': [922], 'K.M.': [923], 'Gurumurthy': [924], 'Rangnekar': [926], 'V.M.': [927], 'Mol.': [928, 1142, 1734, 3172, 3300], 'Cell.': [929, 1004, 1143, 1294, 1735, 3173, 3301], '24:': [932], '1007-1021Crossref': [933], '(215)': [936], 'heterodimeric': [940], 'factor': [942], 'constitutively': [945, 4187], 'consists': [975], 'transactivation': [978], 'subunit': [979, 1065], 'DNA-binding': [983], 'subunits': [984, 1058], 'p50': [985], '(NFκB1)': [986], 'p52': [988, 1682], '(NFκB2),': [989], 'processed': [992], 'precursors': [995], 'p105': [996], 'p100,': [998], 'respectively': [999], '(11Ghosh': [1000], 'Karin': [1002], '109:': [1006], 'S81-S96Abstract': [1007], '(3260)': [1015], 'In': [1018, 1458, 3746], 'unstimulated': [1019], 'conditions,': [1020], 'sequestered': [1023], 'cytoplasm': [1026], 'NFκB(IκB)': [1030], 'remains': [1032], 'inactive.': [1034], 'Upon': [1035], 'stimulation': [1036], 'inflammatory': [1038, 1100, 1290], 'cytokines': [1039, 1291], 'peptide': [1041], 'growth': [1042, 1287, 3929], 'factors,': [1043, 1288], 'phosphorylated': [1046], '(IKK),': [1050], 'multiprotein': [1052], 'complex': [1053], 'consisting': [1054], 'two': [1056, 3243, 3842, 4056, 4148], '(IKKα': [1059], 'IKKβ)': [1061], 'regulatory': [1064], '(IKKγ/NEMO),': [1066], 'undergoes': [1068], 'proteasome-dependent': [1069], 'degradation.': [1070], 'The': [1071, 1699, 1799, 2103, 2284, 2401, 2415, 2445, 2458, 2525, 2572, 2599, 2889, 2927, 2940, 2959, 2977, 3099, 3364], 'released': [1072], 'translocates': [1074], 'nucleus': [1077], 'regulates': [1079, 1450, 3784], 'target': [1083], 'genes': [1084], 'roles': [1087], 'prevention': [1090], 'apoptosis,': [1092, 2095], 'promotion': [1093], 'growth,': [1096], 'responses': [1101], '(12Dolcet': [1102], 'X.': [1103, 1109, 1778], 'Llobet': [1104], 'Pallares': [1106], 'Matias-Guiu': [1108], '446:': [1113], '475-482Crossref': [1114], '(726)': [1117], 'undergo': [1122], 'response': [1125, 3832], 'PI3K': [1127, 1222, 1502, 2193, 2276, 2278, 3517, 3748, 3918], 'pathway': [1128], 'inhibition': [1129, 1223, 4016, 4306], '(13Bost': [1130], 'F.': [1131], 'McKay': [1132], 'Bost': [1134], 'Potapova': [1136], 'O.': [1137], 'Dean': [1138], 'N.M.': [1139], 'Mercola': [1140], '1999;': [1145, 1386, 1583, 2262], '19:': [1146], '1938-1949Crossref': [1147], '(144)': [1150], '14Lee': [1153], 'H.Y.': [1154, 1225, 2130, 2204, 3074, 3520, 4261], 'Srinivas': [1155, 1226, 2131, 2205, 3521, 4262], 'Xia': [1157, 1228, 2133, 2207, 3523, 4264], 'Lu': [1159, 1230, 1325, 2135, 2209, 2247, 3525, 4266], 'Superty': [1161, 1232, 2137, 2211, 3527, 4268], 'LaPushin': [1163, 1234, 2139, 2213, 3529, 4270], 'Gomez-Manzano': [1165, 1236, 2141, 2215, 3531, 4272], 'Gal': [1167, 1238, 2143, 2217, 3533, 4274], 'A.M.': [1168, 1239, 2144, 2218, 3534, 4275], 'Walsh': [1169, 1240, 2145, 2219, 3535, 4276], 'G.L.': [1170, 1241, 2146, 2220, 3536, 4277], 'Force': [1171, 1242, 2147, 2221, 3083, 3537, 4278], 'Ueki': [1173, 1244, 2149, 2223, 3539, 4280], 'Mills': [1175, 1246, 2151, 2225, 2257, 3541, 4282], 'G.B.': [1176, 1247, 2152, 2226, 2258, 3542, 4283], 'Kurie': [1177, 1248, 2153, 2227, 3089, 3543, 4284], 'J.M.': [1178, 1249, 1384, 1431, 1581, 2154, 2228, 3090, 3544, 4285], '2003;': [1182, 1253, 1736, 2158, 2232, 3174, 3302, 3548, 4289], '278:': [1183, 1254, 2159, 2233, 3549, 4290], '23630-23638Abstract': [1184, 1255, 2160, 2234, 3550, 4291], '(55)': [1192, 1263, 2168, 2242, 3558, 4299], 'We': [1195, 1493, 1602, 3561, 4003, 4167, 4310], 'found': [1197], 'stress': [1200], 'kinase,': [1201], '(MKK4),': [1206], 'activates': [1207], 'can': [1214], 'rescue': [1215], 'them': [1216], 'proapoptotic': [1219, 3572], 'effect': [1220, 4250], '(14Lee': [1224, 2129, 2203, 3519, 4260], 'environmental': [1276], 'stresses,': [1277], 'exposure': [1279], 'UV': [1283], 'irradiation,': [1284], 'DNA': [1285, 3358], 'damage,': [1286], '(15Davis': [1292], 'R.J.': [1293, 1330], '2000;': [1295], '103:': [1296], '239-252Abstract': [1297], '(3570)': [1305], 'Consistent': [1308], 'role,': [1312], 'disruption': [1313], 'causes': [1316], 'embryonic': [1317], 'death': [1318], '(16Yang': [1319], 'Tournier': [1321], 'Wysk': [1323], 'H.T.': [1326], 'Xu': [1327], 'Davis': [1329], 'Flavell': [1331], 'R.A.': [1332], 'Proc.': [1333], 'Natl.': [1334], 'Acad.': [1335], 'Sci.': [1336], 'U.': [1337], '1997;': [1340], '94:': [1341], '3004-3009Crossref': [1342], '(258)': [1345], 'Scholar)': [1347, 1588, 4301], 'increases': [1349], 'liver': [1350], '(17Nishina': [1353, 1550], 'Vaz': [1355, 1552], 'Billia': [1357, 1554], 'P.': [1358, 1555], 'Nghiem': [1359, 1556], 'Sasaki': [1361, 1558], 'De': [1363, 1560], 'la': [1364, 1561], 'Pompa': [1365, 1562], 'J.L.': [1366, 1563, 1731, 1782, 3169, 3297], 'Furlonger': [1367, 1564], 'Paige': [1369, 1566], 'Hui': [1371, 1568], 'Fischer': [1373, 1570], 'K.D.': [1374, 1571], 'Kishimoto': [1375, 1408, 1572], 'Iwatsubo': [1377, 1416, 1574], 'Katada': [1379, 1434, 1576], 'Woodgett': [1381, 1578], 'J.R.': [1382, 1579], 'Penninger': [1383, 1430, 1580], 'Development.': [1385, 1582], '126:': [1387, 1584], '505-516Crossref': [1388, 1585], '18Watanabe': [1392], 'Nakagawa': [1394], 'Ohata': [1396], 'Kitagawa': [1398], 'Nishitai': [1400], 'G.': [1401], 'Seo': [1402], 'Tanemura': [1404], 'Wada': [1410], 'Aoki': [1412], 'Arai': [1414], 'Mochita': [1418], 'Watanabe': [1420], 'Satake': [1422], 'Ito': [1424], 'Matsuyama': [1426], 'Mak': [1428], 'T.W.': [1429], 'Nishina': [1432], '250:': [1439], '332-347Crossref': [1440], 'However,': [1444, 3608], 'fully': [1456], 'study,': [1460], 'hypothesized': [1462, 3703, 4246], 'interactions': [1469], 'signaling,': [1472, 3709], 'addressed': [1475], 'using': [1477, 2176, 2520, 2656, 2954, 3111, 3322, 3338, 3443, 3466, 3860, 4084], 'cells.': [1492, 3876, 3953], 'conclude': [1494], 'Lines': [1508], 'Reagents—The': [1510], 'H1299,': [1514], 'H226B,': [1515], 'H226Br,': [1516], 'H332,': [1517], 'H358,': [1518], 'H460,': [1519], 'A549,': [1520, 4320], 'H596,': [1521], 'Calu-6': [1523], 'obtained': [1525], 'American': [1527], 'Type': [1528], 'Culture': [1530], 'maintained': [1533, 1590], 'RPMI': [1535], '1640': [1536], 'medium': [1537, 1595, 1952], 'supplemented': [1538, 1596], '10%': [1540, 1598, 2508], 'fetal': [1541, 1599], 'bovine': [1542, 1600], '(Invitrogen).': [1544, 1869], "Dulbecco's": [1592], 'modified': [1593], "Eagle's": [1594], 'serum.': [1601], 'purchased': [1603, 1624, 1852, 1868], 'LY294002': [1604, 1928, 2030, 3610, 3877, 4114, 4138, 4157, 4212], '(Calbiochem),': [1605], 'paclitaxel': [1606, 1930, 2032, 3615, 4116, 4140, 4159], '(Bristol-Myers': [1607], 'Squibb': [1608], 'Co.),': [1609], 'TNFα': [1610, 3131], '(Leinco': [1611], 'Technologies),': [1612], '4-monophosphate': [1614], '(Sigma),': [1615], 'ImmunoPure': [1617], 'immobilized': [1618], 'A': [1620, 2901, 2956, 3009, 3213], 'beads': [1621, 2600], '(Pierce).': [1622], 'Antibodies—We': [1623], 'rabbit': [1625, 1652, 1659, 3346], 'polyclonal': [1626, 1653, 1660], 'antibodies': [1627, 1654, 1661, 1677], 'against': [1628], 'human': [1629, 3201], 'Ser-473-phosphorylated': [1630], 'AKT': [1631, 2171, 2179, 3857, 3921, 3938, 3948, 3968, 3980, 4015], '(p-AKT1),': [1632], 'Thr-183/Tyr-185-phosphorylated': [1633], 'JNK': [1634, 2191, 4105, 4127], '(p-JNK),': [1635], 'AKT1,': [1636], 'X-chromosome-linked': [1637], '(Cell': [1642, 1647, 2183], 'Signaling': [1643, 1648, 2184], 'Technology),': [1644], 'Technology': [1649], 'Neomarkers);': [1651], 'p85α': [1656], '(Upstate': [1657], 'Biotechnology);': [1658, 1673], 'p65,': [1663], 'p50,': [1664], 'cyclin': [1665], 'D1,': [1666], 'p110α,': [1667], '(Santa': [1671, 1683, 3340], 'Cruz': [1672, 1684, 3341], 'monoclonal': [1676], 'β-actin': [1679], '(Sigma)': [1680, 2052, 2382], 'Biotechnology).': [1685], 'Plasmids—NFκB-Luc': [1686], 'gift': [1689, 1828], 'Dr.': [1691, 1706, 1769, 1815, 1830], 'Bing': [1692], 'Su': [1693], '(M.': [1694, 1709, 1772, 1833], 'Anderson': [1696, 1711, 1774, 1835], 'Center).': [1698, 1837], 'p65': [1700], 'vector': [1702, 1989, 2705, 2763, 4077], 'provided': [1704, 1767, 1813], 'Paul': [1707], 'Chiao': [1708, 1732, 3170, 3298], 'Center)': [1713, 1776], '(19Schmidt': [1714, 3152, 3280], 'Peng': [1716, 3154, 3282], 'Li': [1718, 3156, 3284], 'Sclabas': [1720, 3158, 3286], 'G.M.': [1721, 3159, 3287], 'Fujioka': [1722, 3160, 3288], 'Niu': [1724, 3162, 3290], 'Schmidt-Supprian': [1726, 3164, 3292], 'Evans': [1728, 3166, 3294], 'D.B.': [1729, 3167, 3295], 'Abbruzzese': [1730, 3168, 3296], 'P.J.': [1733, 3171, 3299], '12:': [1737, 3175, 3303], '1287-1300Abstract': [1738, 3176, 3304], '(135)': [1746, 3184, 3312], 'Two': [1749], 'promoter': [1751, 2703, 2770, 2790, 2841, 3250, 3413], 'reporter': [1752, 2697, 2704, 2733, 2762, 2783, 3475], 'constructs': [1753, 1825], 'used.': [1755, 2773, 2793], 'One': [1756], 'contains': [1757, 1801, 3928], '1,064': [1758, 2765], 'base': [1759, 1803, 2766, 2786], 'pairs': [1760, 1804, 2767, 2787], '(from': [1761, 1805], '–1809': [1762], '–745)': [1764], 'Alfred': [1770], 'Yung': [1771, 1785], '(20Sheng': [1777], 'Koul': [1779], 'Liu': [1781, 1783], 'T.J.': [1784], 'W.K.': [1786], 'Biochem.': [1787], 'Biophys.': [1788], 'Commun.': [1790], '292:': [1792], '422-426Crossref': [1793], '(38)': [1796], 'other': [1800, 2776, 3571], '1,978': [1802, 2785], '–1978': [1806], 'translation': [1808], 'start': [1809], 'site)': [1810], 'Ian': [1816], 'de': [1817], 'Belle': [1818], '(The': [1819], 'Burnham': [1820], 'Institute).': [1821], 'Wild-type': [1822], 'plasmid': [1824], 'Jiale': [1831], 'Dai': [1832], 'Retroviral': [1838], 'vectors': [1839], 'expressing': [1840], 'murine': [1841], '(shRNA)': [1846], 'scrambled': [1848, 1861], 'control': [1849, 1862, 4088, 4203], 'shRNA': [1850], '(Open': [1853], 'Biosystems).': [1854], 'Human': [1855], 'small': [1857, 1863], 'interfering': [1858, 1864], 'oligonucleotides': [1866], 'pcDNA3-FLAG-PTEN': [1870], 'constructed': [1872], 'subcloning': [1874], 'FLAG-PTEN': [1875], 'pcDNA3': [1877], 'at': [1878, 1913, 1920, 1931, 1938, 1958, 1994, 2044, 2068, 2391, 2421, 2590, 2617, 2805, 2849, 2935, 3716, 3776, 3993], 'KpnI': [1880], 'XbaI': [1882], 'sites.': [1883], 'Proliferation': [1885], 'Apoptosis': [1887, 1996], 'Assays—Cells': [1888, 2677], 'seeded': [1890, 2799], 'either': [1892, 1925, 3962], '96-well': [1893, 2611], 'plates': [1894, 1902, 2477, 2612, 2682], '(1,000': [1895], 'cells/well)': [1896, 1904], 'proliferation': [1898, 1964, 3577], 'assays': [1899, 2173, 2197, 3477], '24-well': [1901, 2681], '(4,000': [1903], 'assays.': [1907], 'These': [1908], 'conditions': [1909], 'achieved': [1910], '70%': [1911], 'confluence': [1912], 't': [1914, 3441, 3464], '=': [1915], '0.': [1916], 'After': [1917, 1961], 'overnight': [1918, 2071], 'incubation': [1919], '37': [1921, 1939, 1959, 2591, 2806], '°C,': [1922], 'treated': [1926, 2028, 3127], 'concentrations': [1933], 'indicated': [1934, 1955, 2037, 3134], '72': [1936, 3390, 3397], 'h': [1937, 2726, 3987], '°C': [1940, 2070, 2592, 2807, 3371, 3380, 3385, 3391, 3398], 'washed': [1943, 2287, 2449, 2528], 'twice': [1944, 2537], 'phosphate-buffered': [1946, 2291], 'saline': [1947], 'incubated': [1949, 2576, 2616, 2804], 'serum-free': [1951], 'time': [1956, 2035, 3995], 'points': [1957], '°C.': [1960], 'treatment,': [1962, 2085], 'examined': [1966, 2073, 4090, 4311], 'bromide': [1970], '(MTT,': [1971], 'Sigma)': [1972], 'assay.': [1973, 3482], 'Depending': [1974], 'upon': [1975], 'experiment,': [1977], 'values': [1978, 3484], 'calculated': [1980, 2110, 2637], 'relative': [1981], 'untreated': [1983], 'transfectants,': [1990], 'set': [1993], '100%.': [1995], 'measured': [1998, 2724, 3859], 'terminal': [2000, 3205, 3646], 'deoxynucleotidyl': [2001, 3647], 'transferase': [2002, 3648], 'dUTP': [2003, 3649], 'nick-end': [2004, 3650], 'labeling': [2005, 3117, 3651], 'APO-BRDU': [2008], 'staining': [2009], 'kit': [2010, 2182, 2663, 3326], '(Phoenix': [2011], 'Flow': [2012], 'Systems,': [2013], 'San': [2014], 'Diego,': [2015], 'CA)': [2016], 'Hoechst': [2019, 2022, 2050, 3638], 'staining.': [2020, 3639], 'For': [2021, 2083, 2275, 2752, 2774, 2794, 2993, 3187], 'staining,': [2023], 'serum-starved': [2026], 'periods': [2036], 'then': [2039, 2109, 2575, 2810, 3360, 3431], 'fixed': [2040], '4%': [2042], 'paraformaldehyde': [2043], 'room': [2045, 2422, 2618], 'temperature': [2046, 2423, 2619], '20': [2048, 2327, 2386, 2463], 'min.': [2049, 2400, 2632, 3401], '33342': [2051], 'added': [2054, 4065], 'directly': [2055], 'final': [2058], 'concentration': [2059], '10μg/ml.': [2061], 'Cells': [2062], 'stained': [2064], 'dark': [2067], '4': [2069], 'under': [2074], 'Olympus': [2076], 'IX71': [2077], 'fluorescence': [2078], 'microscope': [2079], 'next': [2081, 4039, 4168], 'day.': [2082], 'each': [2084], 'condensed': [2088], 'fragmented': [2090], 'chromosomes,': [2091], 'hallmark': [2093], 'counted': [2097], 'three': [2099, 3461, 4316], 'randomly': [2100], 'chosen': [2101, 2831], 'fields.': [2102], 'percentages': [2104], 'apoptotic': [2106, 3693, 3996, 4209], 'based': [2111, 3636, 3803], 'total': [2114, 3062], 'count.': [2116], 'Western': [2117], 'Analysis': [2118], 'Kinase': [2120], 'Assays—Western': [2121], 'blot': [2122], 'analysis': [2123, 3319], 'performed': [2125, 2175, 2199, 3145, 3321, 3447, 3470], 'nonradioactive': [2178], 'assay': [2181, 2662, 3325], 'Technology)': [2185], 'according': [2186, 2642, 2686, 3146], "manufacturer's": [2189, 2645, 2689], 'instructions.': [2190, 2646, 2690], 'vitro': [2195], '21Cuevas': [2245], 'Watt': [2249], 'Kumar': [2251], 'Siminovitch': [2255], 'K.A.': [2256, 3080], '274:': [2263], '27583-27589Abstract': [2264], '(130)': [2272], 'assays,': [2277, 2699, 3453, 3652], 'immunoprecipitated': [2280, 2519], 'anti-p85': [2282], 'antibody.': [2283], 'immunoprecipitates': [2285, 2526, 2573], 'sequentially': [2288, 2529], '(a)': [2290], 'saline,': [2292], '100': [2293, 2300, 2308, 2312, 2317, 2323, 2429, 2584, 2621], 'μm': [2294, 2309, 2324, 2342, 2361, 2369, 2372, 2375, 2585], 'Na3VO4,': [2295, 2343], '1%': [2296, 2510], 'Triton': [2297, 2349, 2511], 'X-100;': [2298], '(b)': [2299], 'mm': [2301, 2313, 2318, 2321, 2328, 2333, 2336, 2339, 2345, 2366, 2387, 2498, 2503, 2506, 2544, 2549, 2552, 2555, 2565, 2570], 'Tris': [2302, 2314, 2362], '(pH': [2303, 2315, 2330, 2363, 2389, 2500, 2546, 2567], '7.6),': [2304, 2316, 2364], '0.5': [2305], 'm': [2306, 2433], 'LiCl,': [2307], 'Na3VO4;': [2310, 2325], '(c)': [2311], 'NaCl,': [2319, 2334, 2367, 2504, 2550], '1': [2320, 2344, 2432, 2505, 2871, 2969, 3024, 3382, 3387, 3393], 'EDTA,': [2322, 2337, 2507, 2553], '(d)': [2326], 'Hepes': [2329, 2388, 2499, 2545], '7.5),': [2331, 2501], '50': [2332, 2497, 2548, 2578], '5': [2335, 2824, 3373], '30': [2338, 2354, 2377, 2419, 2631], 'NaPPi,': [2340], '200': [2341, 2371], 'phenylmethylsulfonyl': [2346], 'fluoride,': [2347], '0.03%': [2348], 'X-100': [2350, 2512], 'resuspended': [2352, 2384, 2461], 'μl': [2355, 2410, 2430, 2440, 2464, 2579, 2605, 2622], 'reaction': [2358, 2404, 2416], 'buffer': [2359, 2533, 2542, 3040], '(33': [2360], '125': [2365], '15': [2368, 2374], 'MgCl2,': [2370], 'adenosine,': [2373], 'ATP,': [2376], 'μCi': [2378], '[γ-32P]ATP).': [2380], 'PI': [2381, 2402, 2413], '7.5)': [2390], '2': [2392, 2988], 'mg/ml': [2393], 'sonicated': [2395], 'ice': [2397], 'initiated': [2406], 'adding': [2408, 2428], 'suspension.': [2414], 'proceeded': [2417], 'min': [2420, 2595], 'terminated': [2426], 'HCl.': [2434], 'Lipids': [2435], 'extracted': [2437], '600': [2439], 'chloroform:': [2442], 'methanol': [2443], '(1:1).': [2444], 'organic': [2446], 'phase': [2447], 'H2O,': [2451], 'collected,': [2452], 'dried': [2454], 'vacuum': [2456], 'centrifugation.': [2457], 'lipids': [2459], 'chloroform:methanol': [2466], '(1:1)': [2467], 'resolved': [2469, 3432], 'silica': [2471], 'gel': [2472], 'G-60': [2473], 'thin-layer': [2474], 'chromatography': [2475], '(TLC)': [2476], '(Merck)': [2478], 'chloroform:methanol:acetone:acetic': [2480], 'acid:H2O': [2481], '(60:2:': [2482], '23:18:11).': [2483], 'Radiolabeled': [2484], 'phosphate': [2486, 3480], 'visualized': [2488], 'autoradiography.': [2490], 'Phosphatase': [2492], 'Assay—Cells': [2493], 'lysed': [2495], '150': [2502], 'glycerol,': [2509], 'protease': [2514, 2535], 'inhibitors': [2515], '(Sigma).': [2516], 'PTEN-specific': [2522], 'antibody': [2523, 3343], '(Neomarkers).': [2524], 'once': [2530, 2558], 'lysis': [2532], '(without': [2534], 'inhibitors),': [2536], 'low': [2539, 4324], 'stringency': [2540], 'wash': [2541], '(20': [2543, 3029], '7.7),': [2547], '0.1': [2551], '2.5': [2554], 'MgCl2)': [2556], 'Reaction': [2560, 2581], 'Buffer': [2561, 2582], 'without': [2562, 3130], 'substrate': [2563, 4096], '(100': [2564], 'Tris·HCl': [2566], '8.0),': [2568], 'dithiothreitol).': [2571], 'diC8PIP3': [2586], '(Echelon': [2587, 2627, 2664], 'Research': [2588, 2628, 2665], 'Laboratories)': [2589, 2629, 2666], '40': [2594, 2604], 'occasional': [2597], 'mixing.': [2598], 'centrifuged,': [2602], 'supernatant': [2607], 'transferred': [2609, 3042], '(flat': [2613], 'bottom)': [2614], 'malachite': [2624], 'green': [2625], 'reagent': [2626], 'activity': [2635, 2694, 2722, 2738, 2745, 3234, 3481, 3738, 3756, 3769, 3824, 3855], 'standard': [2640], 'curve': [2641], 'Phosphatidylinositol': [2647], '3,4,5-Trisphosphate': [2648], '(PIP3)': [2649], 'Assay—PIP3': [2650], 'quantified': [2652, 3644], 'extracts': [2655], 'PIP3': [2658, 3846], 'mass': [2659], 'enzyme-linked': [2660], 'immunosorbent': [2661], 'directed': [2668], 'manufacturer.': [2671, 3332], 'Transfection': [2673], 'Reporter': [2675], 'Gene': [2676], 'transfected': [2679], 'Lipofectamine': [2684], '(Invitrogen)': [2685, 2817], 'To': [2691, 2867, 3230], 'measure': [2692], 'luciferase': [2693, 2715, 2732, 2737, 2744, 2750], 'NFκB-Luc': [2700], 'co-transfected': [2707], 'pRL-CMV': [2710], 'vector,': [2711], 'expresses': [2713], 'Renilla': [2714, 2749], 'internal': [2718], 'transfection': [2719, 2728], 'control.': [2720], 'Luciferase': [2721], '48': [2725, 2828], 'after': [2727, 3988], 'system': [2734, 3118], '(Promega).': [2735], 'expressed': [2740, 4188, 4323], 'firefly': [2743], 'normalized': [2746], 'activity.': [2751], 'construction': [2753], 'site-directed': [2755], 'mutants': [2756, 3259], 'promoter,': [2760, 2781, 3238], 'containing': [2764, 2784, 3415], 'sequence': [2771, 2791], 'all': [2775], 'experiments': [2777], 'stable': [2795, 4194], 'selection,': [2796], '35-mm': [2801], 'plates,': [2802], 'transfected,': [2803], 'overnight,': [2808], 'replated': [2811], '150-mm': [2813], 'dishes,': [2814], 'G418': [2816], 'added.': [2819], 'Medium': [2820], 'replaced': [2822], 'every': [2823], 'days.': [2825], 'Up': [2826], 'subclones': [2829], 'screening.': [2834], 'Site-directed': [2835], 'Mutagenesis—Mutations': [2836], 'created': [2843], 'putative': [2845, 3244, 3416], 'binding': [2847, 3190, 3211, 3225, 3233, 3246, 3418], 'sites': [2848, 3247, 3419], 'nucleotides': [2850, 2891], '–1574': [2851], '–1565': [2853], '(Box': [2854, 2860, 3251], '1)': [2855], '–1450': [2857], '–1441': [2859], '2)': [2861], 'overlapping': [2863, 2933], 'PCR': [2864, 2911, 2925, 2928, 2941, 2953, 2961, 2995, 3057, 3065, 3107, 3423, 3428], 'follows.': [2866], 'create': [2868, 2983], 'Box': [2870, 2968, 2987, 3023, 3254, 3261, 3265], 'mutant,': [2872], 'primers': [2873, 2900, 2914, 2955, 2998, 3066, 3100], 'were:': [2875, 3000], 'primer': [2876, 2879, 2882, 2886, 3001, 3005], 'A,': [2877], '5′-CGGGGTACCGGATCCTCTTTCAGTTCATTTAGATAGGTGC-3′;': [2878], 'B,': [2880, 3002], '5′-TTTGCCTAAAGATTCAACCTTCCCCCAAATCTGTGTCCTCATGGTGTCAG-3′;': [2881], 'C,': [2883, 3006], '5′-AGGTTGAATCTTTAGGCAAAGGCTGTTACAGTCAAATCTCTGCGAACGAT-3′;': [2884], 'D,': [2887], '5′-CCCAAGCTTGCGGCCGCCGCCGTCTCTCATCTCCCTCG-3′.': [2888], 'mutant': [2890, 3264], 'shown': [2893], 'bold.': [2895], 'Using': [2896], 'pGL3-PTEN-Luc': [2897], 'template,': [2899], 'B': [2903], 'generate': [2907, 2921], '260-base': [2909], 'pair': [2910, 2924, 2932], 'fragment,': [2912], 'C': [2915], 'D': [2917, 3011], '710-base': [2923], 'fragment.': [2926], 'products': [2929, 2942, 3108, 3429], 'had': [2930, 3600, 3729], '20-base': [2931], 'sequences': [2934], '3′-': [2937], '5′-ends.': [2939], 'template': [2947], 'third': [2950], 'round': [2951], 'resulting': [2960], 'product,': [2962], 'region,': [2970], 'cloned': [2972], 'pGL3-Luc': [2974], 'basic': [2975], 'vector.': [2976], 'same': [2978, 3017], 'protocol': [2979, 3014, 3365], 'region': [2989, 3414], 'promoter.': [2992], 'reaction,': [2996], '5′-CTGCAAGGAGAATACAATCCCCCCTTGCCTCTACCCCTAGATTTCC-3′;': [3003], '5′-GGGATTGTATTCTCCTTGCAGGGACCGTCCCTGCATTTCCCTCTAC-3′.': [3007], 'Primers': [3008, 3402], 'those': [3019], 'making': [3022], 'mutants.': [3025], 'Northern': [3026], 'Blotting—Total': [3027], 'μg)': [3030], 'separated': [3032], '1.5%': [3034, 3435], 'agarose': [3035, 3436], 'gels': [3036], '1×': [3038], 'MOPS': [3039], 'Zeta-Probe': [3044], 'blotting': [3045], 'membranes': [3046], '(Bio-Rad).': [3047], 'Probes': [3048], 'glyceraldehyde-3-phosphate': [3050, 3071], 'dehydrogenase': [3051, 3072], 'prepared': [3055, 3060], 'cDNA': [3059], 'RNA.': [3064], '(22Lee': [3073], 'Suh': [3075], 'Y.A.': [3076], 'Lee': [3077], 'J.I.': [3078], 'Hassan': [3079], 'Mao': [3081], 'L.': [3082], 'Gilbert': [3085], 'B.E.': [3086], 'Jacks': [3087], 'Clin.': [3091], '8:': [3095], '2970-2975PubMed': [3096], '5′-TTGAAGACCATAACCCACCACAC-3′': [3104], '5′-GGCAGACCACAAACTGAGGATTG-3′.': [3106], 'labeled': [3110], 'Rediprime': [3113], 'II': [3114], 'random': [3115], 'prime': [3116], '(Amersham': [3119], 'Biosciences).': [3120], 'Electrophoretic': [3121], 'Mobility': [3122], 'Shift': [3123], 'Assays': [3124], '(EMSAs)—Cells': [3125], 'times': [3135], 'fractionated': [3137], 'cytoplasmic': [3139], 'fractions.': [3142], 'EMSAs': [3143], 'method': [3149], 'typical': [3188], 'activity,': [3191, 3722], '30-nucleotide': [3195], 'double-stranded': [3196, 3214], 'κB': [3197], 'oligonucleotide': [3198, 3216], 'immunodeficiency': [3202], 'virus': [3203], 'long': [3204], 'repeat': [3206], '(5′-CTCAACAGAGGGGACTTTCCGAGAGGCCAT-3′;': [3207], 'boldface': [3208], 'indicates': [3209], 'site).': [3212], 'mutated': [3215], '(5′-CTCAACAGAGTTGACTTTTCGAGAGGCCAT-3′)': [3217], 'examine': [3221, 3231], 'DNA.': [3229], 'probes': [3239], 'made': [3241], '1,': [3252, 3262, 3579, 3585], '5′-TTGGGGGAAGGGGGAATCTCTAGGCAAAGG-3′;': [3253], '2,': [3255, 3266], '5′-CAAGGGGGGAGGGTATTCCCCTTGCAGGGA-3′)': [3256], 'their': [3258], '(mutant': [3260], '5′-TTGGGGGAAGGTTGAATCTTTAGGCAAAGG-3′;': [3263], '5′-CAAGGGGGGATTGTATTCTCCTTGCAGGGA-3′).': [3267], 'As': [3268, 4086], 'control,': [3270], 'Oct-1': [3273], 'probe,': [3274], 'Chromatin': [3315], 'Immunoprecipitation': [3316], '(ChIP)': [3317], 'Assay—ChIP': [3318], 'ChIP': [3324], '(Upstate)': [3327], 'recommended': [3329], 'Following': [3333], 'immunoprecipitation': [3334], 'protein-DNA': [3336], 'complexes': [3337], 'anti-p50': [3339], 'Biotechnology)': [3342], 'normal': [3345], 'IgG,': [3347], 'reversal': [3348], 'histone-DNA': [3351], 'cross-links,': [3352], 'recovery': [3354], 'DNA,': [3356], 'purified': [3357], 'amplified': [3361], 'PCR.': [3363], 'follows:': [3368], 'denaturation,': [3369], '95': [3370], 'min;': [3374, 3394], 'amplification,': [3375], '34': [3376], 'cycles': [3377], '94': [3379], 'min,': [3383, 3388], '55': [3384], 'extension,': [3396], '7': [3400], '(5′-CTGGGGAGCTGGTTACACAA-3′': [3405], '5′-CTCCTGTTCTGGATCTGCC-3′)': [3407], 'spanned': [3409], 'generated': [3421], 'product': [3424], '181': [3426], 'bp.': [3427], 'gel.': [3437], 'Statistical': [3438], 'Analysis—Paired': [3439], "Student's": [3440, 3463], 'test': [3442, 3465], 'Microsoft': [3444, 3467], 'Excel': [3445, 3468], 'data': [3450, 3473], 'MTT': [3452], 'conducted': [3456], 'triplicate': [3458], 'repeated': [3460], 'times.': [3462], 'p': [3483], '0.05': [3486], 'less': [3488], 'considered': [3490], 'significant.': [3491], 'Loss': [3493, 3673], 'Enhances': [3494], 'Sensitivity': [3495], 'Apoptosis—We': [3497], 'showed': [3498], 'more': [3505, 3660, 3686, 4200], 'sensitive': [3506, 3661, 4201], 'than': [3507, 3662, 3688, 3741, 3873, 3892, 4202], 'caused': [3513], 'therefore': [3562], 'investigated': [3563, 4169], 'whether': [3564, 4170], 'confers': [3568], 'sensitivity': [3569, 3913, 4134, 4155, 4224], 'stimuli.': [3573], 'Basal': [3574], 'rates': [3575], '(Fig.': [3578, 3584, 3611, 3616, 3626, 3733, 3739, 3764, 3848, 3864, 3898, 3978, 3991, 4117, 4141, 4213], 'left': [3580], 'panels)': [3581, 3587], 'right': [3586], 'similar': [3589, 3758, 3839], 'indicating': [3596], 'no': [3601], 'measurable': [3602], 'effects': [3603, 4210], 'these': [3605, 3826], 'basal': [3606, 3768, 3836], 'parameters.': [3607], 'like': [3609], '1A),': [3612], 'treatment': [3613, 3696, 3915, 4136], '1B),': [3617], 'antimicrotubule': [3621], 'agent,': [3622], 'starvation': [3625, 3944, 3966, 4011], '1C)': [3627], 'induced': [3628, 4008], 'Apoptotic': [3640], 'LY294002-induced': [3667, 3845], '(supplemental': [3669], 'Fig.': [3670], '1).': [3671], 'Increases': [3674], 'Expression': [3676, 4031], 'Inhibits': [3678], 'Signaling—Given': [3680], 'stimuli,': [3694], 'inhibits': [3700], 'alters': [3707], 'mediator': [3712], 'survival,': [3715, 3934], 'level': [3718, 3778], 'expression,': [3721, 4109, 4131], 'both.': [3724], 'Indeed': [3725], 'higher': [3730, 3891], '2A)': [3734], 'lipid': [3736, 3754], '2B)': [3740], 'did.': [3745], 'contrast,': [3747], '(p85': [3750], 'p110)': [3752], '2C),': [3765], 'suggesting': [3766, 4215], 'altered': [3774], 'specifically': [3775], 'Because': [3781], 'negatively': [3783], 'effectors': [3797, 3828], 'AKT,': [3802], 'above': [3806], 'results': [3807], 'predicted': [3809], 'would': [3816, 3945], 'differ': [3817], 'respect': [3819], 'basally': [3829], 'LY294002.': [3834, 4027, 4229], 'Whereas': [3835], '2D)': [3849], 'phosphorylation': [3852, 3949, 3969, 3981, 4092], '(as': [3858], 'GST-GSK3': [3861], 'substrate)': [3863], '2E)': [3865], 'considerably': [3867], 'lower': [3868], 'led': [3878], 'slight': [3881], 'diminution': [3882], 'remained': [3890, 3982], '2E).': [3899], 'associated': [3904], 'increase': [3907], 'enhanced': [3912, 4104, 4129, 4177, 4223], 'inhibitor.': [3919], 'Persistent': [3920], 'Phosphorylation': [3922], 'Serum-starved': [3924], 'Cells—Because': [3926], 'factors': [3930], 'part': [3936], 'activation,': [3939], 'reasoned': [3941], 'prominently': [3946], 'inhibit': [3947], 'Surprisingly': [3954], 'whereas': [3955], 'did': [3958, 4012], 'change': [3960], 'type,': [3964], 'decreased': [3967, 4107, 4126], '2F).': [3979], 'up': [3984], '12': [3986], 'removal': [3990], '2F)': [3992], 'detectable': [3999], '(data': [4000], 'shown).': [4002], 'concluded': [4004], 'require': [4014], 'hence': [4018], 'occurred': [4019], 'distinct': [4022], 'mechanism': [4023], 'Suppression': [4028], 'Is': [4032], 'Prosurvival': [4034], 'Signal': [4035], 'Activated': [4036], 'MKK4—We': [4038], 'sought': [4040], 'rule': [4042], 'out': [4043], 'susceptibility': [4050, 4178], 'differed': [4053], 'types': [4058], 'due': [4059], 'MKK4-independent': [4061], 'factors.': [4062], 'back': [4066], 'introduction': [4072], 'depleted': [4079], 'shRNA.': [4085], 'overexpression': [4100], 'phosphorylation,': [4106, 4128], 'attenuated': [4111], '3A).': [4118], 'Conversely': [4119], 'knockdown': [4121], 'increased': [4133], '3B).': [4142], 'differences': [4145, 4163], 'related': [4161], 'expression.': [4166, 4309], 'contributed': [4174, 4220], 'When': [4184], 'transfection,': [4195], 'transfectants': [4198], 'antiproliferative': [4207], '3C),': [4214], 'High': [4230], 'Confers': [4232], 'Survival': [4234], 'Advantage': [4235], 'Cells—Based': [4238], 'our': [4240], 'observations': [4241], 'observed': [4255], 'mediated': [4303], 'eight': [4312], 'lines,': [4315], '(H460,': [4319], 'H596)': [4322], 'undetecta': [4326]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2011369410', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-14T04:08:54.790535', 'created_date': '2016-06-24'}