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'Jan': [116], '1997https://doi.org/10.1161/01.CIR.95.2.313Circulation.': [117], '1997;95:313–315A': [118], 'number': [119, 616, 654, 677, 1540, 1594], 'clinical': [121, 1578, 1793, 2700], 'trials': [122, 1597, 1686], 'are': [123, 410, 825, 881, 1245, 1414, 1598, 1851, 1906], 'presently': [124], 'evaluating': [125], 'whether': [126, 807], 'stimulating': [127, 165, 1632, 1636], 'glucose': [128, 166, 182, 220, 254, 270, 278, 309, 330, 339, 347, 363, 381, 388, 390, 449, 476, 606, 618, 669, 679, 695, 714, 726, 841, 870, 892, 909, 954, 1069, 1089, 1177, 1197, 1204, 1237, 1262, 1411, 1427, 1431, 1443, 1450, 1459, 1488, 1531, 1558, 1573, 1608, 1614, 1624, 1656, 1812, 1856, 1951, 2014, 2065, 2069, 2091, 2109, 2149, 2210, 2255, 2281, 2314, 2366, 2791, 3466, 3813], 'metabolism': [129, 167, 183, 199, 1090, 1263, 1460, 1550, 1609, 1732, 1809, 1813, 1857, 1929, 2036, 2174, 2480, 2644, 2792, 4104], 'is': [130, 208, 285, 297, 314, 416, 454, 532, 569, 625, 682, 742, 786, 811, 820, 830, 903, 1036, 1066, 1169, 1181, 1191, 1264, 1283, 1339, 1372, 1409, 1555, 1589, 1610, 1814, 1858, 2451, 3283, 3640], 'an': [131, 234, 458, 685, 692, 734, 750, 939, 960, 1265, 1310, 1476, 1570, 1737, 1815, 3084, 3707, 4073], 'effective': [132, 1816], 'therapeutic': [133, 1839], 'approach': [134, 1582, 1588, 1605, 1740, 1817, 4071], 'lessening': [136], 'severity': [138, 289, 3044], 'ischemic': [140, 566, 1005, 1023, 1062, 1467, 1743, 1778, 2021, 2403, 2434, 3287, 3577, 4048], 'injury': [141, 3377], '(see': [142, 368, 973, 1230, 1366, 1648, 1680], 'References': [143, 1943], '1,': [144], '2,': [145], '3': [147, 1368, 1650, 1682], 'for': [148, 255, 338, 362, 371, 448, 456, 464, 471, 674, 697, 833, 931, 976, 1068, 1086, 1270, 1291, 1369, 1623, 1651, 1683, 1708, 1774, 1872, 1969, 2478, 3169, 3600, 3643, 3981], 'reviews).': [149], 'Several': [150], 'pharmacological': [151], 'agents': [152, 1700, 1827, 3132, 3310], 'with': [153, 299, 305, 356, 1566, 1584, 2967, 3316, 3696], 'demonstrated': [154], 'anti-ischemic': [155], 'effects': [156, 212, 824, 875, 2286, 2636, 3922, 4097], 'have': [157, 193, 1128, 1667, 1687, 1693, 1838], 'also': [158, 533, 631, 747, 769, 847, 1082, 1394], 'recently': [159, 351], 'been': [160, 227, 352, 916, 1669], 'shown': [161, 917, 1129, 1670, 1694], 'act': [163, 1717], 'by': [164, 247, 280, 457, 477, 510, 815, 894, 1325, 1493, 1528, 1616, 1630, 1638, 1718, 2263, 2319, 2455, 3378, 4012], '(ie,': [168], 'ranolazine,': [169, 1661], 'trimetazidine,': [170, 1662], 'l-carnitine,': [171, 1663, 1666], 'propionyl': [173, 1665], 'l-carnitine).34': [174], 'Despite': [175], 'these': [176, 1059, 1159, 1699], 'encouraging': [177], 'results,': [178], 'regulation': [180, 2082, 2262, 3195], 'during': [184, 202, 283, 480, 549, 1013, 1080, 1091, 1106, 1179, 1251, 1461, 1484, 1526, 1860, 2115, 2431, 2481, 2548, 3493], 'ischemia': [185, 214, 231, 284, 302, 307, 320, 374, 505, 612, 630, 745, 792, 877, 1081, 1127, 1180, 1320, 1392, 1679, 2059, 2139, 2292, 2454], 'remains': [186, 1116, 1345, 1845], 'poorly': [187], 'understood.': [188], 'Although': [189, 373, 1261, 1576], 'many': [190], 'experimental': [191, 1690], 'studies': [192, 559, 1579, 1691, 1850, 1865], 'addressed': [194], 'changes': [196], 'cellular': [198, 1869, 2588], 'that': [200, 229, 406, 440, 572, 647, 744, 822, 891, 1012, 1038, 1130, 1173, 1277, 1383, 1410, 1511, 1654, 1729, 1799, 1828, 1866], 'occur': [201, 1384, 1702], 'subsequent': [204, 1125], 'ischemia,35': [206], 'little': [207], 'known': [209, 228, 628, 788], 'about': [210], 'on': [215, 287, 560, 840, 878, 1955, 2642, 3089, 3698, 3928, 4102], 'actual': [217], 'transport': [218, 340, 364, 450, 670, 715, 754, 842, 898, 2085, 2232, 2256, 2315, 2356], 'into': [221, 588, 671, 716, 765, 778, 1076], 'heart.': [223, 740, 1006, 1553, 1932, 1972, 2296, 2339], 'It': [224, 296, 568, 741, 785, 819, 1007, 1035], 'has': [225, 349, 914, 927, 1083, 1164], 'long': [226], 'myocardial': [230, 263, 1391, 1613, 1715, 1725, 1821, 1956, 2058, 2187, 2879, 2976, 3126, 3197, 3819, 3982], 'results': [232, 375, 649, 707, 1498], 'increase': [235, 325, 419, 459, 604, 664, 686, 693, 711, 723, 735, 751, 994, 1398, 1502, 1557, 1607, 1655], 'rate': [238, 276, 538, 667, 996, 1175], 'glycolysis': [240, 256, 957, 998, 1163, 1441, 1448], 'a': [242, 323, 335, 377, 384, 417, 468, 489, 516, 525, 536, 602, 652, 662, 675, 709, 721, 730, 919, 944, 979, 1185, 1233, 1396, 1418, 1437, 1500, 1520, 1593, 2061, 2177, 2182, 2553, 3097, 3406, 3641, 3976, 4069], 'switch': [243, 3979], 'from': [244, 258, 271, 331, 428, 801, 1209, 1442, 1449, 1458, 1806, 2238, 2424, 3526, 3706, 3863], 'lactate': [245, 251, 2114], 'uptake': [246, 268, 279, 391, 955, 1178, 1559, 3637, 3769], 'heart': [249, 282, 367, 479, 718, 1141, 1735, 1744, 1779, 1843, 1994, 2042, 2145, 2585, 3142, 3533, 3639, 3703], 'production.5': [252], 'originates': [257], 'both': [259, 424, 651, 2457], 'breakdown': [261, 541], 'glycogen': [264, 540], 'stores': [265], 'blood': [273, 294, 485, 493, 521, 3812], '(Figure).': [274, 1260, 1295], 'dependent': [286], 'reduction': [292, 518, 527], 'flow.6': [295], 'increased': [298, 1040, 1148, 1426], 'less': [300], 'severe': [301, 306, 1014, 1061, 1253, 3103], 'but': [303, 719, 1189, 1308, 1393, 2067], 'decreases': [304], 'when': [308], 'delivery': [310, 382, 1721], 'tissue': [313], 'very': [315, 570], 'low.': [316], 'In': [317, 397], 'any': [318, 582, 1762], 'case,': [319], 'consistently': [321], 'causes': [322, 855, 2060], 'large': [324, 603], 'extraction': [328, 474, 607, 2066], 'blood,': [333], 'reflecting': [334], 'greater': [336, 473, 537, 653, 1101], 'capacity': [337], 'across': [341, 451, 495, 899], 'sarcolemmal': [343, 434, 622, 672, 901, 990, 1048, 1078, 1879], 'membrane.6A': [344], 'family': [345], 'transporters': [348, 619, 637, 656, 2150, 2258], 'only': [350, 720], 'cloned': [353], 'characterized,': [355], 'GLUT-1': [357, 425, 585, 757, 775, 798, 924, 985, 1043, 1073, 1094, 1151, 1831, 1873, 2148], 'GLUT-4': [359, 427, 587, 759, 777, 800, 926, 987, 1045, 1075, 1096, 1153, 1833, 1875, 2146], 'being': [360, 1590, 1600], 'responsible': [361, 1871], 'Reference': [369, 974, 1367, 1649, 1681], '7': [370], 'review).': [372, 1370, 1652, 1684], 'flow-dependent': [378], 'fall': [379], 'decrease': [385, 443, 1307, 1332, 1522, 1561], 'interstitial': [387, 2108], 'levels,8': [389], 'rates': [392, 952, 1018, 1087, 1124, 1132, 1161, 1202, 1244, 1306, 1413, 1422, 1433, 1513], 'can': [393, 1143, 1434, 1464, 1544, 1627, 1701], 'still': [394], 'be': [395, 1009, 1118, 1144, 1167, 1275, 1475, 1545, 1628, 1847], 'accelerated.': [396], 'this': [398, 913, 1052, 1115, 1408, 1581, 1587, 1904], 'issue': [399], 'Circulation,': [401], 'Young': [402, 511, 551, 1326, 2122, 2167, 2277], 'et': [403, 512, 1327, 3201], 'al9': [404, 1328], 'demonstrate': [405], 'if': [407, 629, 789], 'canine': [408, 2144, 2183, 2295], 'hearts': [409, 706, 853], 'subjected': [411], 'low-flow': [413, 2186], 'ischemia,': [414, 950, 1015, 1254, 1302, 1863, 3985], 'there': [415, 514], 'significant': [418, 517, 526, 1501], 'translocation': [422, 583, 764, 773, 796, 810, 922, 983, 1041, 1071, 1834, 1876, 2142, 2206], 'intracellular': [430, 804], 'pool': [431], 'membrane.': [435, 641], 'This': [436, 466, 531, 681, 1371, 1445, 1626], 'important': [437, 929, 961, 1170, 1266, 1311, 1477, 3129], 'finding': [438], 'demonstrates': [439], 'ischemia-induced': [442], 'driving': [446], 'force': [447], 'sarcolemma': [453, 590, 1105, 2153], 'compensated': [455], 'membrane': [462, 660, 781, 970, 991, 1049, 1079, 1156, 2216, 2236], 'conductance': [463], 'glucose.': [465, 2267], 'provides': [467], 'clear': [469], 'mechanism': [470, 1870], 'ischemia.Reductions': [481], 'coronary': [483, 576, 1064, 1335, 2179, 3041, 3138, 3318], 'artery': [484, 577, 3042, 3139, 3319], 'flow': [486, 494, 522, 578, 1065, 2291], 'result': [487, 600, 748, 770, 793, 1435], 'nonuniform': [490], 'distribution': [491], 'left': [497], 'ventricular': [498, 3091], 'wall.': [499], 'With': [500, 1315, 2510, 2752], 'moderate': [502, 947, 1299, 1317], 'level': [503, 1318], 'used': [506, 1321, 1546], 'study': [509, 1324], 'al,9': [513], 'was': [515], 'subendocardial': [520], '(≈60%)': [523], 'without': [524, 1760], 'subepicardial': [529, 594], 'flow.10': [530], 'reflected': [534], 'subendocardium': [544], 'than': [545, 897], 'subepicardium': [548], 'ischemia.7': [550], 'colleagues': [553], 'took': [554], 'care': [555], 'perform': [557], 'their': [558, 763], 'inner': [562], 'half': [563], 'zone.': [567], 'likely': [571], 'reductions': [574], 'did': [579, 598], 'not': [580, 599, 626, 690, 787, 882, 915, 1182, 1907, 2068], 'cause': [581], 'outer': [593, 610], 'layer': [595], 'likewise': [597], 'region.Although': [611], 'clearly': [613], 'increases': [614, 632], 'membrane,911': [623], 'it': [624, 1273, 1509], 'yet': [627, 1165], 'activity': [634, 755, 880, 1247, 1836, 2428], 'residing': [638], 'Studies': [642, 884, 3866], 'skeletal': [644, 844, 2234, 2317], 'muscle12': [645], 'show': [646], 'exercise': [648], 'plasma': [659, 780, 2215], 'twofold': [663], 'vesicles': [673, 2237], 'given': [676], 'transporters.': [680, 699], 'due': [683, 1373, 1424], 'Vmax': [688], 'affinity': [696], 'Increased': [700], 'contractile': [701, 2422], 'work': [702], 'isolated': [704, 851, 886, 2384], 'rat': [705, 852, 2022, 2260, 2338, 3100], 'sevenfold': [710], '3-O-methyl': [713], 'threefold': [722], 'total': [725], 'transporter': [727, 2211, 2282], 'number,13': [728], 'suggesting': [729], 'similar': [731], 'response': [732], 'workload': [737], 'possible': [743, 821], 'may': [746, 958, 992, 1019, 1770], 'addition': [761], 'membrane.Insulin': [767], 'will': [768], 'heart.14': [784], 'insulin': [790, 837], 'same': [803, 817], 'pool,': [805], 'nor': [806], 'stimulation': [808], 'synergistic': [812], 'or': [813, 1135, 1492, 1602, 1634, 1643, 1767, 1832, 1913], 'occurs': [814], 'mechanism.': [818], 'additive': [826], 'vivo,': [828], 'as': [829, 1361, 1659, 1751], 'case': [832], 'effect': [835], 'hypoxia': [839], 'muscle.15': [845], 'Insulin': [846], 'activates': [848], 'hexokinase': [849, 859, 879, 1199, 2336], 'transfer': [857], 'mitochondrial': [862, 2425, 4010], 'membrane,': [863, 902], 'thus': [864], 'increasing': [865, 981, 1618], 'phosphorylation': [867, 893, 2358], 'free': [869], 'cytoplasm.16': [873], 'known.': [883], 'quiescent': [887], 'cultured': [888, 3932], 'cardiomyocytes': [889, 3374], 'suggest': [890], 'hexokinase,': [895], 'rather': [896, 1190], 'rate-limiting': [905, 1621, 2363], 'step': [906], 'insulin-stimulated': [908], 'utilization17': [910], ';': [911], 'however,': [912, 1011], 'working': [920], 'heart.The': [921], 'potentially': [928], 'consequences': [930], 'ability': [933, 1219], 'myocardium': [936, 4046], 'withstand': [938], 'episode': [940, 948], 'ischemia.': [942, 2116, 2188], 'During': [943, 1296, 1352], 'mild': [945, 1297], 'accelerated': [951], 'provide': [959], 'source': [962, 1267, 1287, 1312, 1348, 1363, 2459], 'ATP': [964], 'maintain': [966], 'optimal': [967], 'control': [968, 2239], 'ion': [971], 'flux': [972, 1206, 1255, 1534], '18': [975], 'example).': [977], 'As': [978, 1417], 'result,': [980, 1419], 'well': [993], 'afford': [1000], 'some': [1001], 'protection': [1002], 'should': [1008, 1274], 'recognized,': [1010], 'high': [1016, 1160, 1378, 1420, 1512], 'glycolytic': [1017, 1030, 1055, 1123, 1131, 1215, 1243, 1421, 2398], 'actually': [1020], 'contribute': [1021, 1157, 1465, 1518], 'injury,': [1024, 4049], 'secondary': [1025], 'production': [1028, 1455, 1470], 'products': [1031, 1056, 2399], '(lactate': [1032], 'protons).19': [1034], 'unlikely': [1037], 'contributes': [1050, 1452, 4041], 'accumulation': [1053], 'because': [1057], 'under': [1058], 'more': [1060, 1252], 'conditions,': [1063], 'limiting': [1067], 'uptake.The': [1070], 'potential': [1084], 'implications': [1085], 'reperfusion.': [1092, 2483], 'Presumably,': [1093], 'continue': [1097], 'reside': [1099], 'numbers': [1102], 'reperfusion': [1107, 1462, 1527, 2432], 'gradually': [1109], 'return': [1110, 1133], 'preischemic': [1112, 1137], 'levels.': [1113], 'However,': [1114], 'demonstrated.': [1119], 'Direct': [1120], 'measurements': [1121], 'exceed': [1136], 'rates,2021': [1138], 'even': [1139], 'though': [1140], 'function': [1142, 1505, 1677, 2423, 3095], 'markedly': [1145, 1415], 'impaired.': [1146], 'Whether': [1147, 1826], 'levels': [1149, 1379, 1565], 'determined.It': [1168], 'note': [1172], 'controlled': [1183], 'at': [1184, 1193], 'discrete': [1186], 'regulatory': [1187], 'point': [1188], 'regulated': [1192, 1859], 'multiple': [1194], 'sites,': [1195], 'namely': [1196], 'transport,': [1198], 'activity,': [1200], '6-phosphate': [1205], 'glycogen,': [1210], 'various': [1211], 'points': [1212], 'along': [1213], 'pathway,': [1216], 'mitochondria': [1222], 'oxidize': [1224], 'pyruvate': [1225, 1337, 1536, 1941, 2875], 'cytosolically': [1227], 'derived': [1228], 'NADH': [1229], 'Figure).': [1231], 'Given': [1232], 'constant': [1234], 'supply': [1235], '6-phosphate,': [1238], 'primary': [1240, 1286, 1347], 'regulators': [1241], 'phosphofructokinase': [1249], 'and,': [1250], 'through': [1256, 1535], 'glyceraldehyde': [1257], '3-phosphate': [1258], 'dehydrogenase5': [1259], 'energy': [1269, 1365, 1549, 1731, 1758, 1802, 2039], 'heart,': [1272, 3288, 3470, 3578], 'recognized': [1276], 'oxidation': [1279, 1305, 1338, 1344, 1356, 1402, 1412, 1432, 1451, 1517, 1532, 1615, 1642, 1990, 2015, 2881, 3694], 'fatty': [1281, 1303, 1342, 1354, 1381, 1400, 1495, 1515, 1563, 1640, 1807, 1927, 1953, 1988, 3692], 'acids': [1282, 1382, 1954], 'normally': [1284], 'acetyl': [1289, 1350, 1646], 'CoA': [1290, 1647], 'Krebs': [1293], 'cycle': [1294, 2427], 'episodes': [1300], 'acid': [1304, 1343, 1355, 1401, 1496, 1516, 1564, 1641, 1808, 1928, 1989, 3693], 'remain': [1309], 'energy.': [1314], '(≈40%': [1329], '50%': [1331], 'mean': [1334], 'flow),': [1336], 'impaired,22': [1340], 'CoA.': [1351], 'reperfusion,': [1353], 'quickly': [1357], 'recovers': [1358], 'dominates': [1360], 'part': [1375], 'most': [1386], 'clinically': [1387], 'relevant': [1388], 'conditions': [1389], 'direct': [1397, 1763], 'rates.': [1403], 'main': [1405], 'consequence': [1406], 'inhibited.': [1416], '(possibly': [1423], 'transport)': [1428], 'low': [1430, 2290], 'substantial': [1438], 'uncoupling': [1439, 1446], 'oxidation.': [1444], 'protons': [1457, 1472], 'injury.32021': [1468], 'appears': [1473, 1510], 'contributor': [1478], 'decreased': [1481], 'efficiency': [1482, 1525, 2450], 'seen': [1483], 'reperfusion.2021': [1485], 'Stimulation': [1486, 2312], 'oxidation,': [1489, 1497, 1657], 'either': [1490], 'directly': [1491, 1617, 1631, 1829], 'inhibiting': [1494, 1530, 1639], 'cardiac': [1504, 1524, 1757, 2218, 2361, 2387, 2643, 2692, 2788, 3170, 3645, 3766, 4103], 'efficiency.32021': [1507], 'Therefore,': [1508], 'marked': [1521], 'primarily': [1529], 'dehydrogenase': [1537, 2876], '(PDH)': [1538], '(Figure).A': [1539], 'different': [1542], 'approaches': [1543], 'manipulate': [1548], 'One': [1554], 'circulating': [1562], 'use': [1568], 'infusion': [1571], 'insulin.2': [1575], 'early': [1577, 2482], 'using': [1580], 'met': [1583], 'limited': [1585], 'success,': [1586], 'resurrected,': [1591], 'well-controlled': [1596], 'now': [1599, 1795], 'undertaken': [1601], 'planned.': [1603], 'Another': [1604], 'stimulate': [1612], 'PDH': [1619, 1633, 1637], '(the': [1620], 'enzyme': [1622], 'oxidation).': [1625], 'accomplished': [1629], 'indirectly': [1635], 'lowering': [1644], 'intramitochondrial': [1645], 'Agents': [1653, 1728], 'such': [1658, 1750], 'dichloroacetate,': [1660], 'all': [1668], 'dramatically': [1672], 'improve': [1673], 'recovery': [1674, 3035, 3412], 'mechanical': [1676], 'after': [1678, 1862, 2453], 'Clinical': [1685, 3775], 'confirmed': [1688], 'antianginal': [1696], 'properties': [1697], 'independently': [1703], 'hemodynamic': [1705], 'changes.Traditional': [1706], 'therapies': [1707], 'treatment': [1710, 1776, 3136], 'angina': [1712], 'acute': [1714, 1820], 'infarction': [1716, 1822, 3820], 'improving': [1719], 'oxygen': [1720, 1726], 'and/or': [1722], 'decreasing': [1723], 'demand.': [1727], 'alter': [1730], 'offer': [1736], 'exciting': [1738], 'new': [1739, 4070], 'treating': [1742, 1819, 1842], 'disease': [1745, 1844, 3043, 3140, 3320], 'other': [1747], 'cardiovascular': [1748], 'disorders,': [1749], 'intermittent': [1752], 'claudication.': [1753], 'Pharmacological': [1754], 'optimization': [1755], 'metabolism,': [1759, 2977, 3199], 'causing': [1761], 'negative': [1764], 'hemodynamic,': [1765], 'inotropic,': [1766], 'chronotropic': [1768], 'effects,': [1769], 'prove': [1771], 'particularly': [1772], 'useful': [1773], 'disease,': [1780], 'especially': [1781], 'symptomatic': [1783], 'patients': [1784, 2966, 3315], 'already': [1785], 'receiving': [1786], 'maximally': [1787], 'tolerated': [1788], 'traditional': [1789], 'therapies.': [1790], 'Experimental': [1791, 3579, 4050], 'data': [1794], 'support': [1796, 1968], 'concept': [1798], 'shifting': [1800], 'substrate': [1803, 2476, 3092], 'preference': [1804, 2477], 'away': [1805], 'toward': [1811], 'exercise-induced': [1824], 'angina.123': [1825], 'modify': [1830], 'would': [1837], 'utility': [1840], 'determined.': [1848], 'Additional': [1849], 'required': [1852], 'understand': [1854], 'how': [1855], 'including': [1864], 'define': [1867], 'membrane.Reprint': [1880], 'requests': [1881], 'Dr': [1883], 'Lopaschuk,': [1886], '423': [1887], 'Heritage': [1888], 'Medical': [1889], 'Bldg,': [1891], 'T6G': [1898], '2S2,': [1899], 'Canada.The': [1900], 'opinions': [1901], 'expressed': [1902], 'editorial': [1905], 'necessarily': [1908], 'those': [1909], 'editors': [1912], 'American': [1916, 2648, 3471], 'Association.Download': [1918], 'figureDownload': [1919], 'PowerPoint': [1920], 'Figure': [1921], '1.': [1922], 'Overview': [1923], 'carbohydrate': [1925, 2033, 2880], 'PFK': [1933], 'indicates': [1934], 'phosphofructokinase;': [1935], 'GAPDH,': [1936], 'glyceraldehyde-phosphate': [1937], 'dehydrogenase;': [1938], 'PDH,': [1940], 'dehydrogenase.': [1942], '1': [1944, 2744], 'Oliver': [1945], 'MF,': [1946, 2226], 'Opie': [1947], 'LH.': [1948], 'Effects': [1949, 3082], 'ischaemia': [1957], 'arrhythmias.': [1959], 'Lancet.1994;': [1960], '343:155-158.CrossrefMedlineGoogle': [1961], 'Scholar2': [1962], 'deVillalobos': [1963], 'DH,': [1964], 'Taegtmeyer': [1965, 2332], 'H.': [1966, 2333], 'Metabolic': [1967, 2513, 3004, 3491, 3598], 'post-ischaemic': [1971], 'Lancet.1995;': [1973], '345:1552-1555.CrossrefMedlineGoogle': [1974], 'Scholar3': [1975], 'GD,': [1977, 2303], 'Belke': [1978], 'DD,': [1979], 'Gamble': [1980], 'J,': [1981, 2077, 2102, 2133, 2346, 2350, 2765, 2773, 2953, 3024, 3067, 3242, 3246, 3353, 3365, 3442, 3754, 3842, 3850, 3959, 4089], 'Itoi': [1982], 'T,': [1983, 2307, 2536, 2614, 2719, 2811, 2913, 3018, 3559, 3945, 4031], 'Scho¨nekess': [1984], 'BO.': [1985], 'Regulation': [1986, 2668], 'mammalian': [1993], 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'Austin': [2910], 'Gillette': [2912], 'Fu': [2914], 'Z': [2917], 'Hill': [2919], 'Endoplasmic': [2922], 'Reticulum': [2923], 'Chaperone': [2924], 'GRP78': [2925], 'Protects': [2926], 'Through': [2931], 'Akt': [2932], 'Activation,': [2933], '122:11,': [2936], '(1545-1554),': [2937], '25-May-2018.': [2941], 'Nielsen': [2942], 'Jorsal': [2944], 'Iversen': [2946], 'Tolbod': [2948], 'Bouchelouche': [2950], 'Sørensen': [2952], 'Harms': [2954], 'Flyvbjerg': [2956], 'Bøtker': [2958], 'H': [2959, 2962, 3970], 'Wiggers': [2961], '(2016)': [2963, 3081, 3188, 3280, 3371], 'failure': [2965], 'prediabetes': [2968], 'newly': [2970], 'diagnosed': [2971], 'diabetes': [2972], 'display': [2973], 'abnormalities': [2974], 'Nuclear': [2980, 3109, 3649], 'Cardiology,': [2981, 3050, 3110, 3175, 3292, 3387, 3716], '10.1007/s12350-016-0622-0,': [2982], '25:1,': [2983], '(169-176),': [2984], '1-Feb-2018.': [2988], 'Chiari': [2989, 4122], 'Ledochowski': [2991], 'S': [2992, 3122, 3727, 3967, 4003, 4094], 'Piriou': [2994, 4125], 'V': [2995, 3856, 4126], 'Ischemia-Reperfusion': [2997], 'Concepts': [2998], 'Preconditioning': [3001], 'Postconditioning': [3003], 'Disorders': [3005], 'Critically': [3007], 'Ill': [3008], 'Patients,': [3009], '10.1007/978-3-319-64010-5_22,': [3010], '(453-467),': [3011], '.': [3012, 3613], 'Popovic': [3013], 'Martic': [3015], 'Djordjevic': [3017], 'Pesic': [3019], 'Guazzi': [3021], 'Myers': [3023], 'Mohebi': [3025], 'Arena': [3028], '(2017)': [3030, 3123, 3163], 'Oxygen': [3031], 'consumption': [3032], 'carbon-dioxide': [3034], 'kinetics': [3036], 'prediction': [3039], 'outcome,': [3046], '10.1016/j.ijcard.2017.06.107,': [3051], '248,': [3052], '(39-45),': [3053], '1-Dec-2017.': [3057, 3117], 'Drozd': [3058], 'Ahmadi': [3060], 'Deng': [3062], 'Jiang': [3064, 3369], 'Petryk': [3066], 'Thorn': [3068], 'Stewart': [3070], 'Beanlands': [3072], 'deKemp': [3074], 'DaSilva': [3076], 'Mielniczuk': [3079], 'L': [3080, 3159, 3162, 3563], 'endothelin': [3085], 'receptor': [3086], 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