Combinatorial mRNA Regulation: Iron Regulatory Proteins and Iso-iron-responsive Elements (Iso-IREs)

Name: Work Video:
Duration: 3 min 30 s
Elizabeth C. Theil; Richard S. Eisenstein
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4372], 'growth': [42], 'factors.': [43], 'Combinatorial': [44, 91], 'regulation': [45, 92, 202, 585, 2179, 2192, 2584, 2878, 3186, 3837, 4401], 'transcription': [47], 'coordinate': [49, 97], 'synthesis': [50, 98, 176, 518, 557, 604, 695, 706, 1115], 'groups': [52, 100], 'is': [55, 59, 103, 290, 353, 536, 591, 625, 707, 740, 755, 861, 1213, 1251, 2059, 2070, 2170, 2444, 2453, 2668, 2823, 3040, 3044, 3208, 3233, 3236, 3285, 3313, 3818, 3887, 3946, 4002, 4011, 4034], 'well': [56, 855], 'known': [57, 220, 248, 354, 374], 'and': [58, 108, 125, 147, 152, 177, 195, 217, 250, 259, 265, 508, 579, 721, 735, 782, 812, 874, 918, 929, 935, 1112, 1126, 1147, 1182, 1207, 1223, 1298, 1306, 1319, 1351, 1355, 1450, 1459, 1472, 1670, 1781, 1840, 1845, 1859, 1971, 2118, 2157, 2178, 2205, 2253, 2334, 2337, 2344, 2382, 2398, 2418, 2582, 2593, 2670, 2677, 2768, 2860, 2872, 2882, 2967, 3049, 3090, 3200, 3325, 3416, 3427, 3433, 3482, 3564, 3569, 3633, 3699, 3718, 3734, 3783, 3810, 3827, 3846, 3874, 3898, 3917, 3984, 3988, 3995, 4005, 4010, 4078, 4094, 4125, 4219, 4349, 4383], 'exemplified': [60, 169, 1788], 'by': [61, 170, 263, 593, 712, 750, 757, 1715, 1726, 1737, 1789, 1826, 2072, 2199, 2797, 2879, 3190, 3215, 3630, 4411], 'steroid': [62], 'hormone-responsive': [63], 'genes': [64, 3476, 3514], '(1Darimont': [65], 'B.D.': [66], 'Wagner': [67], 'R.L.': [68], 'Apriletti': [69], 'J.W.': [70], 'Stallcup': [71], 'M.R.': [72], 'Kushner': [73], 'P.J.': [74, 2461, 3391, 3438, 4253], 'Baxter': [75], 'J.D.': [76], 'Fletterick': [77], 'R.J.': [78, 1077, 3160], 'Yamamoto': [79], 'K.R.': [80], 'Genes': [81], 'Dev.': [82], '1998;': [83, 346, 365, 422, 635, 834, 892, 1498, 1702, 1930, 1987, 2045, 2107, 2241, 2317, 2991, 3060, 3500, 3547, 3869, 4209], '12:': [84], '3343-3356Crossref': [85], 'PubMed': [86, 232, 279, 322, 335, 404, 430, 447, 472, 499, 619, 638, 807, 837, 900, 972, 999, 1088, 1107, 1374, 1501, 1531, 1590, 1605, 1627, 1659, 1690, 1705, 1812, 1917, 1936, 1995, 2033, 2048, 2095, 2110, 2219, 2230, 2278, 2325, 2355, 2375, 2469, 2520, 2538, 2625, 2643, 2698, 2723, 2742, 2816, 2897, 2942, 2977, 2999, 3068, 3126, 3277, 3363, 3399, 3446, 3462, 3508, 3536, 3555, 3585, 3605, 3671, 3691, 3860, 3937, 4059, 4120, 4159, 4183, 4212, 4265, 4309, 4335], 'Scopus': [87, 304, 323, 336, 392, 405, 431, 448, 473, 500, 639, 808, 838, 901, 948, 973, 1000, 1048, 1089, 1108, 1375, 1502, 1532, 1606, 1628, 1660, 1691, 1706, 1813, 1918, 1937, 1996, 2034, 2049, 2096, 2111, 2231, 2266, 2279, 2326, 2356, 2470, 2502, 2521, 2539, 2607, 2626, 2644, 2699, 2724, 2743, 2898, 2978, 3000, 3069, 3127, 3259, 3278, 3351, 3364, 3400, 3447, 3463, 3509, 3537, 3556, 3586, 3606, 3672, 3692, 3938, 4060, 4121, 4160, 4184, 4213, 4266, 4310, 4336], '(824)': [88], 'Google': [89, 233, 280, 306, 325, 338, 349, 368, 394, 407, 433, 450, 475, 502, 620, 641, 810, 840, 903, 950, 975, 1002, 1050, 1091, 1110, 1377, 1399, 1504, 1534, 1591, 1608, 1630, 1662, 1693, 1708, 1764, 1815, 1899, 1920, 1939, 1998, 2036, 2051, 2098, 2113, 2144, 2220, 2233, 2244, 2268, 2281, 2328, 2358, 2376, 2472, 2504, 2523, 2541, 2609, 2628, 2646, 2701, 2726, 2745, 2817, 2900, 2943, 2980, 3002, 3071, 3129, 3261, 3280, 3353, 3366, 3402, 3449, 3465, 3511, 3539, 3558, 3588, 3608, 3674, 3694, 3861, 3872, 3940, 4062, 4123, 4162, 4186, 4215, 4268, 4312, 4338], 'Scholar).': [90, 281, 369, 503, 1631, 1663, 1765, 1816, 1940, 1999, 2245, 2473, 2647, 2746, 2818, 2944, 3003, 3072, 3130, 3176, 3281, 3367, 3466, 3559, 3695, 3941, 3993, 4063, 4216], 'mRNA': [94, 204, 668, 675, 683, 709, 1163, 1261, 2195, 2586, 4403], 'utilization': [95], 'unique': [104, 2776], 'currently': [105, 242, 3707], 'oxygen': [109, 161, 2335, 3074, 3735, 3828, 3847], 'metabolism': [110, 162, 3848], 'in': [111, 166, 174, 179, 209, 235, 286, 291, 521, 539, 571, 656, 662, 666, 690, 737, 742, 761, 915, 925, 1133, 1140, 1155, 1220, 1231, 1266, 1347, 1415, 1438, 1551, 1773, 1793, 1850, 2001, 2162, 2189, 2202, 2400, 2454, 2482, 2570, 2846, 2857, 2866, 2910, 3008, 3137, 3182, 3289, 3328, 3370, 3425, 3431, 3471, 3473, 3516, 3647, 3711, 3729, 3742, 3756, 3762, 3776, 3784, 3903, 3909, 3970, 4012, 4065, 4091, 4133, 4235, 4283, 4317, 4346, 4352, 4413], 'animals': [112], '(2–15)': [113], '(see': [114, 684], 'Fig.': [115, 522, 685], '1).': [116], 'The': [117, 504, 524, 1866, 2063, 2246, 2406, 2819, 2851, 3073, 3168, 3228, 3282, 3368, 3696, 3835], 'are': [120, 134, 141, 163, 373, 519, 545, 785, 788, 867, 1410, 2379, 2386, 2431, 2480, 2576, 3322, 3615, 3706, 3722, 3773, 3830, 4282], 'called': [121, 129], 'iso-iron-responsive': [122], '(iso-IREs),1': [124], 'the': [126, 180, 238, 246, 284, 287, 378, 509, 512, 527, 532, 540, 556, 561, 565, 569, 587, 594, 597, 643, 663, 691, 713, 722, 728, 767, 771, 858, 1117, 1156, 1170, 1174, 1179, 1183, 1217, 1228, 1236, 1246, 1259, 1267, 1317, 1349, 1416, 1426, 1434, 1439, 1488, 1549, 1716, 1721, 1727, 1738, 1742, 1768, 1774, 1778, 1782, 1790, 1820, 1828, 1838, 1841, 1871, 1877, 1942, 1945, 1948, 1956, 1963, 2002, 2006, 2011, 2054, 2067, 2075, 2147, 2150, 2153, 2159, 2163, 2171, 2174, 2181, 2190, 2203, 2285, 2297, 2342, 2401, 2413, 2434, 2440, 2442, 2450, 2477, 2483, 2543, 2555, 2558, 2562, 2571, 2653, 2658, 2662, 2666, 2674, 2748, 2780, 2784, 2835, 2840, 2863, 2920, 3014, 3037, 3081, 3085, 3101, 3133, 3148, 3180, 3195, 3221, 3237, 3241, 3293, 3299, 3307, 3316, 3320, 3334, 3375, 3380, 3414, 3561, 3618, 3621, 3651, 3712, 3715, 3730, 3743, 3777, 3785, 3792, 3796, 3811, 3815, 3875, 3883, 3911, 4013, 4023, 4072, 4080, 4222, 4229, 4236, 4277, 4284, 4295, 4364, 4377, 4390, 4414], 'proteins,': [128], 'iso-iron': [130], '(iso-IRPs),': [133], 'homologues.': [136], 'Examples': [137], 'iso-IRE': [139, 167, 664, 1407, 1435, 2167, 2185], 'mRNAs': [140, 241, 911, 1200, 1265, 4396], 'ferritin': [142, 603, 674, 1322, 1350, 1949, 2194], 'concentrate': [144], 'TfR': [146, 714, 1417], 'DMT-1': [148], 'for': [149, 155, 160, 531, 701, 1113, 1258, 1563, 1570, 1635, 1796, 1835, 2122, 2173, 2384, 2396, 2578, 2825, 2877, 3046, 3135, 3204, 3477, 3486, 3617, 3751, 3823, 3950, 3999, 4008, 4016, 4289, 4343], 'uptake,': [151, 927], 'ferroportin': [153], '(Fpn1/IREG1/MTP1)': [154], 'efflux.': [157], 'Several': [158], 'also': [164, 1824, 2299, 3076, 3920, 4035, 4227], 'encoded': [165], 'mRNAs,': [168, 535], '(eALAS)': [173, 1461], 'heme': [175, 577, 1114], 'mt-aconitase': [178, 682, 2449], 'trichloroacetic': [181, 657, 1118], 'acid': [182, 658, 1119, 2774, 2821, 4286], 'cycle.': [183], 'Signals': [184], 'that': [185, 544, 923, 1216, 1245, 1966, 2169, 2296, 2486, 2652, 3315, 3326, 3766, 3882, 4069], 'control': [186, 554, 703, 2918, 4366], 'iso-IRE/iso-IRP': [187, 3816], 'include': [189], 'hydrogen': [192], 'peroxide,': [193], 'activators': [196], 'C.When': [200], 'IRE': [201, 240, 356, 738, 1196, 1221, 1232, 1242, 1484, 1540, 1664, 1822, 1864, 2007, 2068, 2154, 2164, 2544, 2675, 3093], 'function': [205, 924, 1357, 2581, 3189, 3372, 3768], 'was': [206, 245, 254, 1823, 2196, 3919, 4409], 'last': [207], 'described': [208], 'Minireview': [211], '(1990)': [212], 'only': [213, 247, 626, 856, 2481, 2925], 'two': [214, 743, 2247, 3020, 3294, 3317, 3764], 'IRE-mRNAs': [215], '(ferritin': [216], 'TfR)': [218], 'were': [219, 1164, 1856, 3997], '(2Theil': [221, 268, 608, 1579, 2208, 3849], 'E.C.': [222, 269, 341, 360, 418, 442, 609, 888, 1275, 1367, 1496, 1580, 1600, 1700, 1925, 1983, 2043, 2105, 2209, 2236, 2313, 3850, 3864], 'J.': [223, 270, 297, 385, 412, 419, 610, 633, 796, 882, 889, 941, 1011, 1015, 1037, 1368, 1380, 1525, 1581, 1616, 1648, 1684, 1745, 1880, 1911, 1977, 1984, 2027, 2089, 2125, 2210, 2259, 2307, 2314, 2366, 2495, 2534, 2600, 2639, 2694, 2807, 2893, 2933, 2960, 2988, 3057, 3252, 3344, 3454, 3457, 3497, 3527, 3594, 3680, 3851, 3926, 4165, 4172, 4254, 4324], 'Biol.': [224, 271, 298, 344, 363, 386, 420, 611, 797, 890, 942, 1370, 1527, 1582, 1617, 1649, 1686, 1913, 1929, 1985, 2029, 2091, 2211, 2239, 2260, 2315, 2367, 2465, 2496, 2601, 2808, 2934, 2961, 2989, 3058, 3253, 3345, 3395, 3442, 3498, 3532, 3595, 3681, 3852, 3867, 3927, 4173, 4255, 4325], 'Chem.': [225, 272, 300, 388, 421, 612, 798, 891, 944, 1583, 1618, 1650, 1928, 1986, 2212, 2262, 2316, 2368, 2464, 2498, 2603, 2809, 2935, 2962, 2990, 3059, 3255, 3347, 3394, 3441, 3499, 3596, 3682, 3853, 3928, 4174, 4256, 4326], '1990;': [226, 273, 613, 1584, 1809, 2213, 3854], '265:': [227, 274, 614, 1585, 2214, 3855], '4771-4774Abstract': [228, 275, 615, 1586, 2215, 3856], 'Full': [229, 276, 425, 427, 616, 802, 804, 895, 897, 1083, 1085, 1587, 1622, 1624, 1654, 1656, 1933, 1990, 1992, 2216, 2320, 2322, 2372, 2813, 2939, 2994, 2996, 3063, 3065, 3503, 3505, 3550, 3552, 3600, 3602, 3686, 3688, 3857, 3932, 3934, 4178, 4180, 4260, 4262, 4330, 4332], 'Text': [230, 277, 426, 428, 617, 803, 805, 896, 898, 1084, 1086, 1588, 1623, 1625, 1655, 1657, 1934, 1991, 1993, 2217, 2321, 2323, 2373, 2814, 2940, 2995, 2997, 3064, 3066, 3504, 3506, 3551, 3553, 3601, 3603, 3687, 3689, 3858, 3933, 3935, 4179, 4181, 4261, 4263, 4331, 4333], 'PDF': [231, 278, 429, 618, 806, 899, 1087, 1589, 1626, 1658, 1935, 1994, 2218, 2324, 2374, 2815, 2941, 2998, 3067, 3507, 3554, 3604, 3690, 3859, 3936, 4182, 4264, 4334], 'Scholar),': [234, 621, 2052, 2282, 2329, 2542, 3609, 3873, 4339], 'contrast': [236, 4134], 'many': [239], 'known.': [243, 2062], 'Iron': [244, 2945, 3163, 3212], 'signal,': [249], 'knowledge': [251], 'structure': [253, 261, 358, 1177, 1206, 1224, 1233, 1404, 1479, 2008, 2168], 'limited': [255], 'sequence': [258, 1139, 1222, 1249, 1296, 1305, 1769, 1834, 2156, 2435, 2764], 'secondary': [260, 1176, 1455], 'determined': [262], 'prediction': [264], 'enzymatic/chemical': [266], 'probes': [267], 'Annotation': [282], 'literature': [285, 3744], 'intervening': [288], 'period': [289], 'Refs.': [292, 791], '4Rouault': [293], 'T.A.': [294, 382, 938, 1522, 1681, 1908, 2024, 2086, 2256, 2492, 2597, 2706, 3249, 3341, 3544], 'Klausner': [295, 383, 939, 1519, 1678, 1905, 2021, 2083, 2257, 2493, 2598, 2709, 3250, 3342], 'R.D.': [296, 384, 940, 1520, 1679, 1906, 2022, 2084, 2258, 2494, 2599, 2710, 3251, 3343], 'Inorg.': [299, 387, 943, 2261, 2497, 2602, 3254, 3346], '1996;': [301, 319, 389, 799, 945, 1619, 1651, 2263, 2499, 2517, 2604, 2622, 3256, 3274, 3348, 3929, 4327], '1:': [302, 390, 946, 2264, 2500, 2605, 3257, 3349], '494-499Crossref': [303, 391, 947, 2265, 2501, 2606, 3258, 3350], '(40)': [305, 393, 949, 2267, 2503, 2608, 3260, 3352], 'Scholar,': [307, 326, 339, 395, 408, 434, 451, 476, 951, 976, 1003, 1051, 1092, 1378, 1592, 1609, 1694, 1900, 1921, 2037, 2099, 2221, 2234, 2269, 2359, 2505, 2524, 2610, 2629, 2702, 2727, 2981, 3262, 3354, 3450, 3540, 3589, 3675, 3862, 4163, 4187], '5Hentze': [308, 2506, 2611, 3263], 'M.W.': [309, 1075, 1386, 1751, 1886, 2131, 2507, 2612, 3264], 'Kuhn': [310, 1614, 1646, 2508, 2531, 2613, 2636, 2691, 2890, 3265], 'L.C.': [311, 1615, 1647, 2509, 2532, 2614, 2637, 2692, 2891, 3266], 'Proc.': [312, 827, 1097, 2510, 2615, 2713, 3116, 3267, 3575, 4049, 4110, 4149, 4202], 'Natl.': [313, 828, 1098, 2511, 2616, 2714, 3117, 3268, 3576, 4050, 4111, 4150, 4203], 'Acad.': [314, 829, 1099, 2512, 2617, 2715, 3118, 3269, 3577, 4051, 4112, 4151, 4204], 'Sci.': [315, 830, 1100, 2513, 2618, 2716, 3119, 3270, 3578, 4052, 4113, 4152, 4205], 'U.': [316, 831, 1101, 2514, 2619, 2717, 3120, 3271, 3579, 4053, 4114, 4153, 4206], 'S.': [317, 490, 832, 990, 1065, 1102, 2515, 2620, 2718, 3121, 3272, 3580, 3591, 3677, 3979, 4054, 4115, 4154, 4207], 'A.': [318, 833, 1005, 1007, 1019, 1023, 1057, 1067, 1103, 1524, 1683, 1803, 1910, 2026, 2088, 2516, 2621, 2719, 3122, 3273, 3581, 4055, 4116, 4155, 4208], '93:': [320, 2518, 2623, 3275], '8175-8182Crossref': [321, 2519, 2624, 3276], '(1126)': [324, 2522, 2627, 3279], '6Eisenstein': [327, 396, 2222, 2270, 3355], 'R.S.': [328, 397, 630, 795, 826, 2223, 2271, 2348, 2737, 2970, 3115, 3356, 3664, 3925, 3973, 4048, 4109, 4148, 4201, 4302, 4323], 'Annu.': [329, 398, 2224, 2272, 2349, 2971, 3357, 3665, 4303], 'Rev.': [330, 399, 2225, 2273, 2350, 2972, 3358, 3666, 4304], 'Nutr.': [331, 400, 634, 2226, 2274, 2351, 2973, 3359, 3458, 3667, 4305], '2000;': [332, 401, 444, 1045, 1080, 1602, 2227, 2275, 2352, 2974, 3360, 3533, 3582, 3597, 3668, 3683, 4175, 4257, 4306], '20:': [333, 402, 2228, 2276, 2353, 2975, 3361, 3534, 3669, 4307], '627-662Crossref': [334, 403, 2229, 2277, 2354, 2976, 3362, 3670, 4308], '(565)': [337, 406, 2232, 2280, 2357, 2979, 3365, 3673, 4311], '7Theil': [340, 2235, 3863], 'Met.': [342, 361, 2237, 3865], 'Ions': [343, 362, 2238, 3866, 3983], 'Syst.': [345, 364, 2240, 3868], '35:': [347, 366, 2242, 3870], '403-434PubMed': [348, 367, 2243, 3871], 'Scholar.': [350], 'Now': [351], 'much': [352, 1252, 4273], 'about': [355, 3745], 'tertiary': [357], '(7Theil': [359], 'Multiple': [370], 'signaling': [371], 'pathways': [372, 3721], 'converge': [376], 'on': [377, 516, 1173, 1190, 1295, 2166, 2590, 3019, 3080, 3220, 3419, 3737, 4363], 'IRE/IRP': [379, 588, 702, 4087], 'interaction': [380, 3794], '(4Rouault': [381, 937, 2255, 2491, 2596, 3248, 3340], '8Ke': [409, 879], 'Y.': [410, 484, 880, 984, 1009, 1805, 1975, 2305, 2363, 2804, 2930, 2957], 'Wu': [411, 881, 1976, 2306], 'Leibold': [413, 883, 1978, 2308, 2364, 2805, 2931, 2958], 'E.A.': [414, 884, 1801, 1979, 2309, 2365, 2806, 2932, 2959, 3529], 'Walden': [415, 823, 885, 1364, 1980, 2310, 3980, 4170, 4198], 'W.E.': [416, 824, 886, 1365, 1981, 2311, 4171, 4199], 'Theil': [417, 441, 887, 1274, 1366, 1495, 1599, 1699, 1924, 1982, 2042, 2104, 2312], '273:': [423, 893, 1988, 2318, 2992, 3061, 3501], '23637-23640Abstract': [424, 894, 1989, 2319], '(121)': [432, 902, 1997, 2327], '9Ke': [435, 1593], 'Y.H.': [436, 1594], 'Sierzputowska-Gracz': [437, 1493, 1595, 1697, 2040, 2102], 'H.': [438, 478, 978, 1494, 1596, 1698, 2041, 2103, 2459, 3389, 3436, 3525, 3977, 4249], 'Gdaniec': [439, 1597], 'Z.': [440, 1492, 1598, 1696, 2039, 2101], 'Biochemistry.': [443, 1497, 1601, 1701, 2044, 2106, 2738], '39:': [445, 1603], '6235-6242Crossref': [446, 1604], '(44)': [449, 1607, 3587], '10Fleming': [452, 952], 'M.D.': [453, 953, 1039], 'Trenor': [454, 954], 'III,': [455, 955], 'C.C.': [456, 956], 'Su': [457, 957], 'M.A.': [458, 494, 958, 994, 1073], 'Foernzler': [459, 959], 'D.': [460, 960, 1063, 1277], 'Beier': [461, 961], 'D.R.': [462, 962, 3496], 'Dietrich': [463, 963], 'W.F.': [464, 488, 964, 988], 'Andrews': [465, 965, 1040], 'N.C.': [466, 966, 1041], 'Nat.': [467, 967], 'Genet.': [468, 968], '1997;': [469, 496, 969, 996, 1396, 1528, 1687, 1761, 1896, 1914, 2030, 2092, 2141, 2739, 3123, 4056, 4117, 4156], '16:': [470, 970], '383-386Crossref': [471, 971], '(1015)': [474, 974], '11Gunshin': [477, 977], 'Mackenzie': [479, 979], 'B.': [480, 980, 1021, 1384, 1392, 1749, 1757, 1884, 1892, 2129, 2137, 2951, 3521], 'Berger': [481, 981], 'U.V.': [482, 982], 'Gunshin': [483, 983], 'Romero': [485, 985], 'M.F.': [486, 986], 'Boron': [487, 987], 'Nussberger': [489, 989], 'Gollan': [491, 991], 'J.L.': [492, 992, 1033], 'Hediger': [493, 993, 1072], 'Nature.': [495, 995, 1044], '388:': [497, 997], '482-488Crossref': [498, 998], '(2632)': [501, 1001], 'combinatorial': [505], 'RNA/protein': [506], 'family': [507], 'effects': [510, 3079, 4418], 'complex': [515], 'illustrated': [520, 592, 711, 741], '1.': [523], 'result': [525], 'RNA-binding': [528], 'specificity,': [530], 'different': [533, 1199, 1264, 2184, 3021, 3191], 'iso-IRE-containing': [534], 'quantitative': [537, 688, 3727], 'differences': [538, 3007, 3181, 3728, 4351], 'expression': [541, 2948, 3780, 4382], 'finely': [546], 'tuned': [547], 'over': [548, 555, 3096, 4419], 'range.': [551], 'Such': [552, 4064], 'precise': [553], 'each': [559, 667, 2387], 'relates': [563, 646], 'central': [566, 1303, 3831], 'role': [567, 3382, 4342], 'normal': [572], 'cell': [573, 3833, 4378], 'biology:': [574], 'trafficking,': [576], 'synthesis,': [578], 'cellular': [580, 3329, 4398], 'ATP': [581], 'production.The': [582], 'flexibility': [583], 'using': [586], 'mRNA/protein': [589], 'interactions': [590, 1237], 'liver': [595, 3944], 'where': [596], 'same': [598, 1260, 1268, 1440, 2402, 2556], 'amount': [599], 'induces': [602], 'up': [605, 3961], '100-fold': [607], 'but': [622, 2053, 3145, 4276], 'induced': [627, 3303], '2–3-fold': [628], '(3Eisenstein': [629], 'Blemings': [631, 3108, 4041, 4102, 4141], 'K.P.': [632, 3109, 4042, 4103, 4142], '128:': [636], '2295-2298Crossref': [637], '(141)': [640], 'Scholar);': [642, 3512], 'difference': [644], 'likely': [645, 3723], 'narrow': [649], 'tolerance': [650], 'cells': [652, 2847, 3649, 3908, 4223, 4319], 'concentration': [654, 3786], 'changes': [655, 3302, 3327, 3747], 'cycle': [659], 'enzymes.': [660], 'Differences': [661], 'suggest': [669, 4068], 'higher': [671, 1253], 'percentage': [672], 'will': [676, 3409, 3769, 4375, 4384], 'be': [677, 1168, 1735, 2551, 2761, 3410, 3661, 3754, 3770, 3808], 'bound': [678], 'IRPs': [680, 1211, 2298, 2859], 'than': [681, 1262, 2395], '3),': [686, 3801], 'allowing': [687], 'variations': [689, 3710, 3761, 3775, 4412], 'response': [692, 2340, 3817], 'signals.': [697], 'An': [698], 'alternate': [699], 'mechanism': [700], 'regulated': [708], 'turnover,': [710], 'IRE.Figure': [715], '3IRE·': [716], 'IRP': [717, 1564, 2408, 2904, 2947, 3022, 3188, 3767, 3825], 'complexes:': [718], 'IRP1': [719, 734, 749, 848, 1186, 1794, 2252, 2397, 2437, 2767, 2833, 2867, 3048, 3089, 3105, 3136, 3214, 3232, 3371, 3878, 3897, 3916, 3945, 4138, 4371], 'phosphorylation': [720, 763, 2346, 3876, 4027, 4070, 4270, 4280, 4345, 4353, 4374], 'Fe-S/apo': [723], 'cycle;': [724], 'IRP2': [725, 736, 853, 1969, 2254, 2399, 2778, 2786, 2827, 3050, 3091, 3149, 3625, 3645, 3705, 3738, 3749, 3880, 3899, 3918, 4316, 4344, 4373], 'sensitivity': [726, 2330, 3813, 4030, 4230], 'loop/bulge.The': [730], 'differential': [731, 842, 3078, 3793], 'behavior': [732], 'recognition': [739], 'ways.': [744], 'Left,': [745], 'indirect': [746], 'activation': [747, 4293], 'altering': [751], 'Fe-S': [752, 2451, 2563, 2659, 2791, 2864, 3218, 3229, 3283, 3308, 3376, 3422, 3469, 3612, 4024, 4233], 'cluster': [753, 2452, 2660, 2865, 3219, 3284, 3309, 3377, 3423, 3487, 3613, 4025, 4234], 'stability': [754], 'enhanced': [756, 2844, 3045], 'phosphorylation.': [758], 'For': [759], 'IRP2,': [760, 2769], 'contrast,': [762], 'appears': [764, 1733], 'modulate': [766], 'redox': [768, 2852], 'state': [769, 2853, 3010], 'protein.': [772, 2785, 3211], 'Red,': [773], 'wild': [774, 4136], 'type;': [775], 'yellow,': [776], 'S138A.': [777], 'Phosphomimetic': [778, 4089], 'mutants': [779], 'S138D': [780, 4093], '(orange)': [781], 'S138E': [783], '(blue)': [784], 'shown.': [786], 'Data': [787], 'taken': [789], '37Schalinske': [792], 'K.L.': [793, 2729, 3107, 3923, 4040, 4101, 4140, 4321], 'Eisenstein': [794, 825, 2736, 3114, 3924, 4047, 4108, 4147, 4200, 4322], '271:': [800, 1620, 1652, 3930, 4328], '7168-7176Abstract': [801, 3931, 4329], '(123)': [809, 3939, 4337], 'Scholar': [811, 1535], '39Brown': [813, 4188], 'N.M.': [814, 4189], 'Anderson': [815, 2730, 4190], 'S.A.': [816, 1923, 2731, 4191], 'Steffen': [817, 3110, 4043, 4104, 4143, 4192], 'D.W.': [818, 3111, 4044, 4105, 4144, 4193], 'Carpenter': [819, 4194], 'T.B.': [820, 4195], 'Kennedy': [821, 3974, 4196], 'M.C.': [822, 3975, 4197], '95:': [835, 4210], '15235-15240Crossref': [836, 4211], '(73)': [839, 4214], 'Scholar.Right,': [841], 'iso-IRPs': [845, 3797], 'iso-IREs.': [847, 3788], 'binds': [849, 854, 1972], 'all': [850], 'iso-IREs,': [851], 'whereas': [852], 'when': [857, 1853], 'present': [862, 1154], '(Fig.': [863, 1288, 1341, 1555, 3800, 4037, 4098], '2).': [864, 1289], 'Lanes': [865], '1–5': [866], 'iso-IREs': [868, 1855, 3799], 'ferritin,': [870], 'Fer-ΔU6,': [871], 'TfR,': [872], 'eALAS,': [873], 'mt-aconitase,': [875], 'respectively,': [876], 'Ref.': [878, 1514, 3971], 'Scholar.View': [904], 'Large': [905, 1542], 'Image': [906, 1543], 'Figure': [907, 1544], 'ViewerDownload': [908, 1545], '(PPT)Iso-IRE': [909], 'StructureIRE-containing': [910], 'have': [912, 1130, 1291, 1666, 2300, 2758, 3077, 4359], 'been': [913, 1131, 1143, 2548, 2650, 2683, 2923, 3901, 4272], 'identified': [914, 2249], 'vertebrates,': [916], 'invertebrates,': [917], 'bacteria.': [919], 'They': [920], 'encode': [921, 3841], 'storage,': [928], 'export': [930], '(mammals,': [931, 1122], 'birds,': [932], 'amphibia,': [933, 1123], 'insects,': [934, 1125], 'bacteria)': [936], '12Donovan': [1004], 'Brownlie': [1006], 'Zhou': [1008], 'Shepard': [1010], 'Pratt': [1012], 'S.J.': [1013], 'Moynihan': [1014], 'Paw': [1016], 'B.H.': [1017], 'Drejer': [1018], 'Barut': [1020], 'Zapata': [1022], 'Law': [1024], 'T.C.': [1025], 'Brugnara': [1026], 'C.': [1027, 1094, 1149, 1390, 1755, 1847, 1890, 2135, 3519], 'Lux': [1028], 'S.E.': [1029], 'Pinkus': [1030, 1032], 'G.S.': [1031], 'Kingsley': [1034], 'P.D.': [1035], 'Palis': [1036], 'Fleming': [1038], 'Zon': [1042], 'L.I.': [1043], '403:': [1046], '779-781Crossref': [1047], '(1338)': [1049], '13McKie': [1052], 'A.T.': [1053], 'Marciani': [1054], 'P.': [1055, 1394, 1759, 1894, 2139, 2526, 2631, 2686, 2885, 3593, 3679], 'Rolfs': [1056], 'Brennan': [1058], 'K.': [1059, 1061, 4247], 'Wehr': [1060], 'Barrow': [1062], 'Miret': [1064], 'Bomford': [1066], 'Peters': [1068], 'T.J.': [1069], 'Farzaneh': [1070], 'F.': [1071], 'Hentze': [1074, 1385, 1750, 1885, 2130], 'Simpson': [1076], 'Mol.': [1078, 1369, 1526, 1685, 1912, 2028, 2090, 3530, 3545], 'Cell.': [1079, 3531, 3546], '5:': [1081, 1931], '299-309Abstract': [1082], '(1183)': [1090], '15Alén': [1093], 'Sonenshein': [1095], 'A.L.': [1096], '1999;': [1104, 2466, 2535, 2640, 2695, 2894, 3396, 3443, 3459], '96:': [1105], '10412-10417Crossref': [1106], '(132)': [1109], 'Scholar)': [1111, 1287, 1709, 2114, 2966, 4124, 4313], 'cycle/ATP': [1120], 'production': [1121], 'fish,': [1124], 'bacteria).': [1127], 'No': [1128], 'IREs': [1129, 1153, 1290, 1323, 1414, 1462, 2016], 'detected': [1132], 'plants,': [1134], 'although': [1135, 2914, 3650], 'an': [1136, 1324, 1406, 1672, 2424, 2790, 3217, 3802, 3820, 3947], 'IRE-hybridizable,': [1137], 'nonferritin': [1138], 'soybean': [1141], 'has': [1142, 2293, 2423, 2547, 2649, 2682, 2922, 3139, 3151, 3900, 4271], 'observed.': [1144], '2M.': [1145], 'Ragland': [1146], 'E.': [1148, 1388, 1613, 1645, 1753, 1846, 1888, 2133, 2528, 2633, 2688, 2887, 4251], 'Theil,': [1150, 1848], 'unpublished': [1151], 'results.': [1152], '5′': [1157], '3′': [1159], 'noncoding': [1160], 'regions': [1161], 'originally': [1165], 'thought': [1166], 'structurally': [1169], 'same,': [1171], 'based': [1172, 1189, 2589, 3418], 'predicted': [1175, 2438, 2567, 3809, 4278], 'stem': [1180, 1779, 2069], 'loop': [1181, 1467, 1723, 2822, 2837], 'similarity': [1184], 'binding.': [1187, 4020, 4088], 'However,': [1188, 2747], 'comparisons': [1191], 'among': [1192], 'larger': [1193], 'numbers': [1194, 1445], 'sequences': [1197, 1243, 1345], 'coupled': [1201], 'additional': [1203, 1325], 'studies': [1204, 2148, 2595, 3420], 'purified': [1210], 'it': [1212, 3312], 'now': [1214], 'apparent': [1215], 'mRNA-specific': [1218, 1436], 'divergences': [1219], 'define': [1225, 1863], 'isoforms': [1226], 'IREs.': [1229], 'Variations': [1230], 'selectively': [1234, 1637, 1967], 'influence': [1235, 1356, 2869], 'iso-IRPs.PrimaryComparisons': [1239], 'animal': [1241], 'reveal': [1244], 'conservation': [1247, 1297, 1429], 'identity': [1250, 2443, 2765], '(>90%': [1254, 2393], 'identity)': [1255, 1271, 2394], 'between': [1256, 1263, 1777, 1837, 2391, 2412, 2766], 'species': [1257, 1269, 1441, 2392, 2403], '(36–85%': [1270], '(16Johansson': [1272], 'H.E.': [1273], 'Templeton': [1276], 'Metal': [1278, 3982], 'Ion': [1279], 'Gene': [1280, 3985], 'Regulation.': [1281, 3986], 'Marcel': [1282], 'Dekker,': [1283], 'Inc.,': [1284], 'New': [1285, 3165, 3990], 'York2001Google': [1286], '26–30': [1292], 'nucleotides': [1293], '(based': [1294], 'footprint),': [1300], 'CAGUG': [1304], 'residue': [1309], 'five': [1310, 1411], 'bases': [1311], 'upstream.': [1312], 'Complementary': [1313], 'base': [1314, 1474, 1560, 1668, 1730, 1739, 1771, 1868, 1953, 2117, 2160], 'pairs': [1315, 1669, 1772, 2161], 'flank': [1316], 'CAGUGX.': [1320], 'In': [1321, 1766, 2446, 3004, 3083, 3177], 'set': [1326, 4081], 'conserved': [1328, 1465, 1728, 2390], 'bases,': [1329], 'U/C': [1330], 'G-C,': [1331], 'upstream': [1332], 'create': [1335], 'pocket': [1337, 1961], 'related': [1338], 'iso-IRP2': [1339, 1578, 1641], '3).': [1342], 'Conserved': [1343], 'non-IRE': [1344], 'occur': [1346, 3515], 'both': [1348, 2579, 2858, 3047, 3844, 3896], 'TfR-IRE': [1352], '(17Dix': [1358], 'D.J.': [1359, 3456], 'Lin': [1360], 'P.-N.': [1361], 'McKenzie': [1362], 'A.R.': [1363], '1993;': [1371], '231:': [1372], '230-240Crossref': [1373], '(58)': [1376], '18Schlegl': [1379], 'Gegout': [1381, 1746, 1881, 2126], 'V.': [1382, 1747, 1882, 2127], 'Schlager': [1383, 1748, 1883, 2128], 'Westhof': [1387, 1752, 1887, 2132], 'Ehresmann': [1389, 1391, 1754, 1756, 1889, 1891, 2134, 2136], 'Romby': [1393, 1758, 1893, 2138], 'RNA.': [1395, 1760, 1895, 2140], '3:': [1397, 1762, 1897, 2142, 2467, 3397, 3444], '1159-1172PubMed': [1398, 1763, 1898, 2143], 'Scholar).Figure': [1400], '2Iso-IRE': [1401], 'structure.': [1402, 1456], 'Top,primary': [1403], '(TfR-IREb);': [1408], 'there': [1409], 'copies': [1412], 'turnover': [1418, 2288, 3031, 3043], '(a,': [1420], 'b,': [1421], 'c,': [1422], 'd,': [1423], 'e)).': [1424], 'Note': [1425], 'high': [1427, 2763, 4017, 4296], 'interspecies': [1428], '(>95%),': [1430], 'which': [1431, 2422, 2665, 3223, 3235, 3610, 3655, 3840, 3910, 4084], 'contrasts': [1432], 'variation': [1437], '(15–65%)': [1442], '(GenBankTM': [1443], 'accession': [1444], 'M11507,': [1446], 'X01060,': [1447], 'M58040,X13753,': [1448], 'X55348,': [1449], 'AW454691.': [1451], 'Bottom': [1452, 1476], 'left,': [1453], 'hairpin': [1454, 2165], 'IL/B': [1457, 1483, 1506, 2012, 2078], '(ferritin)': [1458, 1485], 'C-bulge': [1460, 1539, 2014, 2076], 'illustrate': [1463], 'terminal': [1466, 1553], 'variable': [1469], 'midstem': [1470], 'distortion': [1471, 1713, 1780], 'helix': [1473, 1776, 1833, 1946], 'pairs.': [1475], 'right,': [1477], 'three-dimensional': [1478], 'MC-SYM/NMR': [1480], 'model': [1481, 2681], 'viewed': [1486], 'major': [1489, 4361], 'groove': [1490, 1965, 2065], '(21Gdaniec': [1491], '37:': [1499, 1703, 2046, 2108], '1505-1512Crossref': [1500, 1704, 2047, 2109], '(76)': [1503, 1707, 2050, 2112], 'Scholar).Yellow,': [1505], 'cavity;': [1507], 'blue,': [1508], 'docked': [1509], 'metal': [1510], '(Co(III)': [1511], 'hexamine).': [1512], '(See': [1513], '20Addess': [1515, 1901], 'K.J.': [1516, 1675, 1902, 2018, 2080], 'Basilion': [1517, 1676, 1903, 2019, 2081], 'J.P.': [1518, 1677, 1904, 2020, 2082, 2704], 'Rouault': [1521, 1680, 1907, 2023, 2085, 2705, 3543], 'Pardi': [1523, 1682, 1909, 2025, 2087], '274:': [1529, 1688, 1915, 2031, 2093], '72-83Crossref': [1530, 1689, 1916, 2032, 2094], '(167)': [1533, 1692, 1919, 2035, 2097], 'compare': [1537], 'structure.)View': [1541], '(PPT)SecondaryIso-IREs': [1546], 'fold': [1547], 'CAGUGX': [1550, 1872], 'hexaloop': [1554, 1743, 1783, 1842, 1873], '2)': [1556], 'containing': [1557], 'C-G': [1559, 1636, 1867], 'pair': [1561, 1740, 1869, 1954], 'required': [1562, 2577, 2752, 2824, 3203, 3411, 4288], 'binding,': [1565, 1787, 2588, 3184], 'because': [1566, 2829], 'substitution': [1567, 1829], 'A': [1569], 'G': [1571], 'prevents': [1572], 'either': [1575, 2010], 'iso-IRP1': [1576], '19Henderson': [1610], 'B.R.': [1611, 1643], 'Menotti': [1612, 1644, 2527, 2632, 2687, 2886], '4900-4908Abstract': [1621, 1653], '(103)': [1629, 1661], 'Substitution': [1632], 'U-A': [1634], 'inhibits': [1638], '(19Henderson': [1642], 'stems': [1665], '9–10': [1667], 'form': [1671, 2416, 2789, 3230, 4314], 'A-helix': [1673], '(20Addess': [1674, 2017, 2079], '21Gdaniec': [1695, 2038, 2100], 'small': [1712], 'caused': [1714], 'conserved,': [1717], 'unpaired': [1718], 'bulge,': [1724], 'created': [1725], 'G-C': [1729, 1952], 'pair.': [1731], 'Structure': [1732], 'modulated': [1736], 'closing': [1741], '(18Schlegl': [1744, 1879, 2124], 'addition,': [1767], 'upper': [1775], 'contributes': [1784], '30-fold': [1791], 'change': [1792], 'CAA/UUG': [1797], '→': [1798], 'UUG/CAA': [1799], '(22Leibold': [1800], 'Laudano': [1802], 'Yu': [1804], 'Nucleic': [1806], 'Acids': [1807], 'Res.': [1808], '18:': [1810, 2536, 2641, 2696, 2895], '1819-1824Crossref': [1811], '(84)': [1814], 'Melting': [1817], 'cooperativity': [1818], 'entire': [1821], 'influenced': [1825], 'engineering': [1827], 'one': [1831, 3291], 'natural': [1832, 1854], 'another': [1836], 'bulge/loop': [1839], '3Y.': [1843], 'Ke': [1844], 'manuscript': [1849], 'preparation.': [1851], 'compared.TertiaryNMR': [1857], 'spectroscopy': [1858], 'nuclease': [1860], '(protein/chemical)': [1861], 'probing': [1862], 'structures.': [1865], 'across': [1870], 'pushes': [1874], 'AGU': [1875], 'into': [1876, 1959], 'solvent': [1878], '23Cliftan': [1922], 'Thorp': [1926], 'H.H.': [1927], '679-689Abstract': [1932], '(15)': [1938], 'At': [1941], 'middle': [1943], 'IRE,': [1950], 'folds': [1955], 'internal/loop': [1957], 'bulge': [1958], 'large': [1964, 2064, 4387], 'enhances': [1968], 'metals': [1973], '(8Ke': [1974, 2304], 'Protonation': [2000], 'physiological': [2003], 'alters': [2005], 'at': [2009, 2074, 2839, 4083], 'proton': [2055], 'acceptor': [2056], '(cytosine?': [2057], 'phosphate?)': [2058], 'yet': [2060, 2759], 'not': [2061, 2488, 2788], 'enlarged': [2071], 'distortions': [2073], 'creating': [2115], 'specific': [2116, 3697], 'ribose': [2119], 'contact': [2120], 'sites': [2121, 3698, 4281], 'Scholar).Taken': [2145], 'together': [2146], 'show': [2149], 'impact': [2151, 4362], 'primary': [2155], 'foundation': [2172], 'selective': [2175, 3185], 'iso-IRP': [2176], 'use': [2182], 'mRNAs.': [2186, 2291], 'trans-Factor': [2187], 'participation': [2188], 'translational': [2191], 'first': [2197, 2407], 'suggested': [2198, 2549], 'data': [2200], 'obtained': [2201, 2684], '1970s': [2204], 'early': [2206], '1980s': [2207], 'since': [2250], 'then,': [2251], 'specifically': [2283], 'inhibit': [2284], 'translation': [2286], 'IRE-containing': [2290, 4395], 'It': [2292, 2648], 'become': [2294], 'clear': [2295, 3314], 'distinct': [2301], 'properties': [2303], 'environmental': [2332], 'signals,': [2336], 'mechanisms': [2338, 3700, 3765], '(6Eisenstein': [2347, 2969, 3663, 4301], '24Guo': [2360], 'B.,': [2361, 2802, 2928], 'Yu,': [2362, 2803, 2929, 2956], '1994;': [2369, 2720, 2810, 2936], '269:': [2370, 2811, 2937], '24252-24260Abstract': [2371, 2812, 2938], 'Scholar).Iso-IRP': [2377], 'StructureIso-IRPs': [2378], 'homologues': [2381], '(as': [2383], 'iso-IREs)': [2385], 'more': [2388, 3890], 'highly': [2389], '(61%': [2404], 'identity).': [2405], 'identified,': [2409], 'IRP1,': [2410, 4092, 4357], 'cycles': [2411], '(apo-c-aconitase)': [2417], '(c-aconitase),': [2421], '[4Fe-4S]': [2425, 3243], 'iron-sulfur': [2426, 3244, 3384], 'cofactor.Iso-IRP1When': [2427], 'peptides': [2428], 'c-aconitase': [2430, 4073], 'compared': [2432], 'cDNA,': [2441], '>98%.': [2445], 'crystals': [2447], 'solvent-filled': [2456], 'cleft': [2457, 2560, 2573, 2667], '(25Beinert': [2458, 3388, 3435], 'Kiley': [2460, 3390, 3437, 4252], 'Curr.': [2462, 3392, 3439], 'Opin.': [2463, 3393, 3440], '152-157Crossref': [2468, 3398, 3445], '(176)': [2471, 3401, 3448], 'By': [2474], 'analogy,': [2475], 'assuming': [2476], 'IRP-specific': [2478], 'insertions': [2479], 'surface': [2484], 'loops': [2485], 'do': [2487], 'affect': [2489], 'folding': [2490], '26Kaldy': [2525, 2630], 'Moret': [2529, 2634, 2689, 2888], 'R.': [2530, 2635, 2690, 2889, 4167], 'EMBO': [2533, 2638, 2693, 2892], '6073-6083Crossref': [2537, 2642, 2697, 2896], '(48)': [2540, 2645, 2700, 2899, 3001, 3070], 'site': [2546, 2842, 2876], 'close': [2552], 'as': [2557, 3386, 3567], 'cluster.': [2564], 'Some': [2565], 'residues': [2566, 2856, 4033], 'reside': [2569], 'putative': [2572], 'iso-IRP1/c-aconitase': [2575], 'function/RNA': [2587], 'site-directed': [2591], 'mutagenesis': [2592], 'cross-linking': [2594], 'hypothesized': [2651], 'presence': [2654], 'absence': [2656, 3103], 'modulates': [2661], 'extent': [2663], 'open': [2669], 'able': [2671], 'bind': [2673], 'complex,': [2676], 'evidence': [2678], 'supporting': [2679], 'this': [2680, 3198], '(26Kaldy': [2685, 2884], '42Basilion': [2703], 'Massinople': [2707], 'C.M.': [2708], 'Burgess': [2711], 'W.H.': [2712], '91:': [2721], '574-578Crossref': [2722], '(108)': [2725], '43Schalinske': [2728], 'Tuazon': [2732], 'P.T.': [2733], 'Chen': [2734, 3112, 4045, 4106, 4145], 'O.S.': [2735, 3113, 4046, 4107, 4146, 4425], '36:': [2740], '3950-3958Crossref': [2741], '(63)': [2744], 'detailed': [2749, 3300], 'structural': [2750, 3301], 'analyses': [2751], 'prove': [2754], 'such': [2755, 3566, 3759], 'notion': [2757], 'completed.Iso-IRP2The': [2762], '61%,': [2770], 'excludes': [2771], '73-amino': [2773, 2820, 4285], 'insertion': [2775, 4287], 'near': [2779, 4003], 'amino': [2781], 'terminus': [2782], 'does': [2787], 'cluster;': [2792], 'regulates': [2794, 2946, 3213, 4086], 'targeted': [2798], 'proteasomal': [2799, 3634], 'degradation': [2800, 2828, 2845, 3720], '(24Guo': [2801, 2927], 'iron-induced,': [2826], 'chimera': [2831], 'IRP2-specific': [2836], 'inserted': [2838], 'analogous': [2841, 3513], 'displayed': [2843], 'excess': [2849], 'iron.': [2850], 'cysteine': [2855], 'complexation': [2861], 'can': [2868, 3332, 3807], 'provide': [2873], 'potential': [2875], 'oxyradicals': [2883], 'Scholar).Multifactorial': [2901], 'Regulation': [2902], 'FunctionThe': [2905], 'ratio': [2906, 2921, 3778], 'IRP1/IRP2': [2908], 'varies': [2909], 'cell-specific': [2912, 2917, 3760, 3774], 'fashion,': [2913], 'exploration': [2915], 'studied': [2924], 'briefly': [2926], 'post-transcriptionally': [2949], '(27Guo': [2950], 'Brown': [2952], 'F.M.': [2953], 'Phillips': [2954], 'J.D.,': [2955], '1995;': [2963], '270:': [2964], '11653-16529Google': [2965], 'post-translationally': [2968, 3018], '28Goessling': [2982], 'L.S.': [2983, 3052], 'Mascotti': [2984, 3053], 'D.P.': [2985, 3054], 'Thach': [2986, 3055], 'R.E.': [2987, 3056], '12555-12557Abstract': [2993, 3062], 'addition': [3005, 3178], 'steady': [3009], 'concentrations': [3011], 'iso-IRPs,': [3013], 'signal': [3016, 3039, 3892], 'acts': [3017], 'activity': [3023, 3713, 3914], 'parameters:': [3024], 'direct': [3025], '(IRP1)': [3028, 4076], '(IRP2)': [3032], 'differing': [3034], 'sensitivities.': [3035], 'When': [3036, 3789], 'heme,': [3041], '(28Goessling': [3051], 'iso-IRPs.': [3082], 'sum,': [3084], 'relative': [3086], 'contributions': [3087], 'vary': [3095], 'broad': [3098], 'including': [3100], 'complete': [3102], '(29Schalinske': [3106, 4039, 4100, 4139], '94:': [3124, 4057, 4118, 4157], '10681-10686Crossref': [3125, 4058, 4119, 4158], '(57)': [3128, 4061, 4122, 4161], 'Ablation': [3131], 'gene': [3134, 3150, 3407], 'mice': [3138], 'no': [3140], 'detectable': [3141], 'phenotype': [3142], 'date,': [3144], 'loss': [3146, 3643], 'very': [3152], 'severe': [3153], 'consequences': [3154], '(30Rouault': [3155], 'T.': [3156, 3542], 'Badman': [3157], 'D.G.': [3158], 'Bergeron': [3159], 'Brittenham': [3161], 'G.M.': [3162], 'Chelators:': [3164], 'Development': [3166], 'Strategies.': [3167], 'Saratoga': [3169], 'Group,': [3170], 'Ponte': [3171], 'Verda': [3172], 'Beach,': [3173], 'FL2000:': [3174], '133-144Google': [3175], 'IRP/IRE': [3183], 'expands': [3194], 'versatility': [3196], 'sensory': [3201], 'network': [3202], 'maintaining': [3205], 'homeostasis.Iso-IRP1IRP1/c-aconitase': [3207], 'bifunctional': [3210], 'building': [3216], 'apoprotein,': [3222], 'blocks': [3224], 'activity.': [3227, 3739], 'c-aconitase,': [3234], 'cytosolic': [3238], 'isoform': [3239], 'mitochondrial,': [3242], 'enzyme,': [3245], '(mt-aconitase)': [3247], 'key': [3287], 'determinant': [3288], 'selecting': [3290], 'possible': [3295], 'functions.': [3297], 'Although': [3298], 'upon': [3304, 3772], 'formation': [3305, 3488], 'remain': [3310, 3659], 'unknown,': [3311], 'functions': [3318], 'mutually': [3323], 'exclusive': [3324], 'status': [3331], 'drive': [3333], 'its': [3337, 3631], 'functional': [3338], 'extremes': [3339], 'shifts': [3369], 'associated': [3373], 'assembly': [3378, 3424], 'emphasize': [3379], 'emerging': [3381], 'biosensors': [3387], 'Scholar).Likely': [3403], 'number': [3405], 'products': [3408], 'deliver': [3413], 'sulfur,': [3417], 'nitrogenase': [3426, 3472], 'copper': [3428], 'trafficking': [3429], 'yeast': [3432, 4130], 'humans': [3434], '33Pena': [3451], 'M.M.O.': [3452], 'Lee': [3453], 'Thiele': [3455], '129:': [3460], '1251-1260Crossref': [3461], '(602)': [3464], 'Assembly': [3467], 'clusters': [3470], 'bacteria': [3474], 'involves': [3475], 'localized': [3478], 'generation': [3479], 'sulfide': [3481], 'delivery': [3483], '(31Zheng': [3489], 'L.': [3490, 3572], 'Cash': [3491], 'V.L.': [3492], 'Flint': [3493], 'D.H.': [3494], 'Dean': [3495], '13264-13272Abstract': [3502], '(571)': [3510], 'eucaryotes': [3517], '(34Voisine': [3518], 'Schilke': [3520], 'Ohlson': [3522], 'M.': [3523, 4169], 'Beinert': [3524, 3976, 4248], 'Marszalek': [3526], 'Craig': [3528], '3677-3684Crossref': [3535], '(72)': [3538], '48Land': [3541], '2:': [3548], '807-815Abstract': [3549], '(164)': [3557], 'Understanding': [3560], 'accessory': [3562], 'factors': [3565], 'NO': [3568], 'H2O2': [3570], '(35Oliveira': [3571], 'Drapier': [3573], 'J.C.': [3574], '97:': [3583], '6550-6555Crossref': [3584], '36Kim': [3590, 3676], 'Ponka': [3592, 3678], '275:': [3598, 3684, 4176, 4258], '6220-6226Abstract': [3599, 3685], '(129)': [3607, 3693], 'regulate': [3611], 'formation,': [3614], 'problems': [3616], 'future.Iso-IRP2Iron': [3619], 'decreases': [3620], 'pool': [3623], 'through': [3626, 3654], 'oxidation,': [3628], 'followed': [3629], 'ubiquitination': [3632], 'degradation.': [3635, 4291], 'Agents': [3636], 'capable': [3637], 'generating': [3639], '⋅NO': [3640], 'NO+promote': [3642], 'cultured': [3648], 'exact': [3652], 'details': [3653], 'these': [3656], 'agents': [3657], 'act': [3658], 'defined': [3662], 'iron-induced': [3702, 4290], 'oxidation': [3703, 3717], 'undefined.': [3708], 'Cell-specific': [3709], 'ubiquitin': [3719], 'contribute': [3725], 'effect': [3731], 'Apparent': [3740], 'inconsistencies': [3741], 'hypoxia-induced': [3746], 'activity,': [3750], 'example,': [3752], 'may': [3753, 4358], 'attributed': [3755], 'part': [3757], 'IRP2.The': [3763], 'superimposed': [3771], 'IRP1:IRP2': [3782], 'combined': [3790], 'enormous': [3803], 'exquisite': [3812], 'illuminated.Phosphorylation,': [3819], 'Iron-independent': [3821], 'Means': [3822], 'Modulating': [3824], 'FunctionIron': [3826], 'homeostasis': [3829, 4408], 'biology.': [3834], 'cytokine': [3836], 'IRE-mRNAs,': [3839], 'indicate': [3881], 'iso-IRE/IRP': [3884], 'system': [3886], 'integrated': [3888], 'general': [3891], 'transduction': [3893], 'pathways.Phosphorylation': [3894], 'demonstrated': [3902], 'phorbol': [3904], '12-myristate': [3905], '13-acetate-treated': [3906], 'HL-60': [3907, 4318], 'stimulated': [3921], '(37Schalinske': [3922, 4320], 'Purified': [3942], 'rat': [3943], 'efficient': [3948], 'substrate': [3949], 'bovine': [3951], 'brain': [3952], '(PKC)': [3956], '(Km': [3957], '∼0.5': [3958], 'μm),': [3959], 'accommodating': [3960], '2': [3963], 'mol': [3964], 'phosphate/mol': [3966], '(reviewed': [3969], '32Eisenstein': [3972], 'Silver': [3978], 'W.': [3981], 'Chapman': [3987], 'Hall,': [3989], 'York1997:': [3991], '157-216Google': [3992], 'Ser-138': [3994, 4001], 'Ser-711': [3996], 'substrates': [3998], 'PKC.': [4000], 'Asp-125': [4004], 'His-126': [4006], '(required': [4007], 'catalysis)': [4009], 'region': [4014], 'critical': [4015], 'affinity': [4018], 'Removal': [4021], 'increases': [4026], '5-fold;': [4028], 'chymotrypsin': [4029], 'adjacent': [4032], 'increased': [4036], '3)': [4038, 4099], 'vitro': [4066], 'observations': [4067], 'controls': [4071], '⇔': [4074], 'apo-c-aconitase': [4075], 'interconversion': [4077], 'influences': [4079], 'point': [4082], 'mutations': [4090, 4218], 'S138E,': [4095], 'destabilized': [4096], 'failed': [4126], 'rescue': [4128], 'aconitase-deficient': [4129], 'grown': [4131, 4224], 'aerobically': [4132], 'type': [4137], '38Narahari': [4164], 'Ma': [4166], 'Wang': [4168], '16227-16234Abstract': [4177], '(53)': [4185], 'Both': [4217], 'S138A': [4220], 'rescued': [4221], 'anaerobically.': [4225], 'Mutation': [4226], 'altered': [4228], 'bacterial': [4237], 'FNR': [4239], '(40Bates': [4240], 'D.M.': [4241], 'Popescu': [4242], 'C.V.': [4243], 'Khoroshilova': [4244], 'N.': [4245], 'Vogt': [4246], 'Munck': [4250], '6234-6240Abstract': [4259], '(70)': [4267], 'Scholar).IRP2': [4269], 'less': [4274], 'studied,': [4275], 'PKC': [4279, 4292, 4381], 'stabilized': [4294], 'affinity,': [4297], 'reduced': [4298], 'suggesting': [4340], 'regulation.Cell': [4347], 'type-': [4348], 'tissue-specific': [4350], 'IRP,': [4355], 'particularly': [4356], 'interorgan': [4365], 'mammalian': [4368], 'metabolism.': [4370], 'reflect': [4376], 'specificity': [4379], 'add': [4385], 'dimension': [4388], 'signals.PerspectiveCombinatorial': [4399], 'encoding': [4404], 'obscured': [4410], 'magnitude': [4415], '50–100-fold': [4423], '(47Chen': [4424], 'Schali': [4426]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2011230039', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-14T04:10:13.708218', 'created_date': '2016-06-24'}
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