Abstract CT104: Antitumor activity of the anti-PD-1 monoclonal antibody MK-3475 in melanoma(MEL): Correlation of tumor PD-L1 expression with outcome

Name: Work Video:
Duration: 3 min 30 s
Adil Daud; Omid Hamid; Antoni Ribas; F. Stephen Hodi; Wen‐Jen Hwu; Richard Kefford; Jedd D. Wolchok; Peter Hersey; Jeffrey S. Weber; Richard W. Joseph; Tara C. Gangadhar; Roxana Dronca; Amita Patnaik; Hassane M. Zarour; Anthony M. Joshua; Kevin Gergich; Dianna Wu; Jared Lunceford; Kenneth Emancipator; Marisa Dolled‐Filhart; Nicole Y. K. Li‐Jessen; Scot Ebbinghaus; Soonmo Peter Kang; Caroline Robert
{'id': 'https://openalex.org/W2011044258', 'doi': 'https://doi.org/10.1158/1538-7445.am2014-ct104', 'title': 'Abstract CT104: Antitumor activity of the anti-PD-1 monoclonal antibody MK-3475 in melanoma(MEL): Correlation of tumor PD-L1 expression with outcome', 'display_name': 'Abstract CT104: Antitumor activity of the anti-PD-1 monoclonal antibody MK-3475 in melanoma(MEL): Correlation of tumor PD-L1 expression with outcome', 'publication_year': 2014, 'publication_date': '2014-10-01', 'ids': {'openalex': 'https://openalex.org/W2011044258', 'doi': 'https://doi.org/10.1158/1538-7445.am2014-ct104', 'mag': '2011044258'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2014-ct104', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5018322482', 'display_name': 'Adil Daud', 'orcid': 'https://orcid.org/0000-0002-6617-8421'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Adil I. Daud', 'raw_affiliation_strings': ['1UCSF School of Medicine, San Francisco, CA;'], 'affiliations': [{'raw_affiliation_string': '1UCSF School of Medicine, San Francisco, CA;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028592995', 'display_name': 'Omid Hamid', 'orcid': 'https://orcid.org/0000-0002-8238-4655'}, 'institutions': [{'id': 'https://openalex.org/I4210104507', 'display_name': 'Angeles Clinic and Research Institute', 'ror': 'https://ror.org/01ct2ab72', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1282927834', 'https://openalex.org/I4210104507']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Omid Hamid', 'raw_affiliation_strings': ['2The Angeles Clinic and Research Institute, Los Angeles, CA;'], 'affiliations': [{'raw_affiliation_string': '2The Angeles Clinic and Research Institute, Los Angeles, CA;', 'institution_ids': ['https://openalex.org/I4210104507']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083745558', 'display_name': 'Antoni Ribas', 'orcid': 'https://orcid.org/0000-0003-3669-8458'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Antoni Ribas', 'raw_affiliation_strings': ['3David Geffen UCLA School of Medicine, Los Angeles, CA;'], 'affiliations': [{'raw_affiliation_string': '3David Geffen UCLA School of Medicine, Los Angeles, CA;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084967339', 'display_name': 'F. Stephen Hodi', 'orcid': 'https://orcid.org/0000-0001-6825-091X'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'F. Stephen Hodi', 'raw_affiliation_strings': ['4Dana-Farber Cancer Institute, Boston, MA.'], 'affiliations': [{'raw_affiliation_string': '4Dana-Farber Cancer Institute, Boston, MA.', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104110089', 'display_name': 'Wen‐Jen Hwu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wen-Jen Hwu', 'raw_affiliation_strings': ['5The University of Texas MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '5The University of Texas MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062978331', 'display_name': 'Richard Kefford', 'orcid': 'https://orcid.org/0000-0001-9251-9229'}, 'institutions': [{'id': 'https://openalex.org/I129604602', 'display_name': 'University of Sydney', 'ror': 'https://ror.org/0384j8v12', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I129604602']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Richard Kefford', 'raw_affiliation_strings': ['6University of Sydney, Sydney, Australia.'], 'affiliations': [{'raw_affiliation_string': '6University of Sydney, Sydney, Australia.', 'institution_ids': ['https://openalex.org/I129604602']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054656505', 'display_name': 'Jedd D. Wolchok', 'orcid': 'https://orcid.org/0000-0001-6718-2222'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}, {'id': 'https://openalex.org/I39965400', 'display_name': 'Kettering University', 'ror': 'https://ror.org/03rcspa57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39965400']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jedd Wolchok', 'raw_affiliation_strings': ['7Memorial-Sloan Kettering Cancer Center, New York, NY;'], 'affiliations': [{'raw_affiliation_string': '7Memorial-Sloan Kettering Cancer Center, New York, NY;', 'institution_ids': ['https://openalex.org/I1334819555', 'https://openalex.org/I39965400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055038393', 'display_name': 'Peter Hersey', 'orcid': 'https://orcid.org/0000-0002-3064-737X'}, 'institutions': [{'id': 'https://openalex.org/I129604602', 'display_name': 'University of Sydney', 'ror': 'https://ror.org/0384j8v12', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I129604602']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Peter Hersey', 'raw_affiliation_strings': ['6University of Sydney, Sydney, Australia.'], 'affiliations': [{'raw_affiliation_string': '6University of Sydney, Sydney, Australia.', 'institution_ids': ['https://openalex.org/I129604602']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047177507', 'display_name': 'Jeffrey S. Weber', 'orcid': 'https://orcid.org/0000-0002-4962-2957'}, 'institutions': [{'id': 'https://openalex.org/I3019308854', 'display_name': 'Moffitt Cancer Center', 'ror': 'https://ror.org/01xf75524', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019308854']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeffrey S. Weber', 'raw_affiliation_strings': ['8H. Lee Moffitt Cancer Center, Tampa, FL;'], 'affiliations': [{'raw_affiliation_string': '8H. Lee Moffitt Cancer Center, Tampa, FL;', 'institution_ids': ['https://openalex.org/I3019308854']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034715033', 'display_name': 'Richard W. Joseph', 'orcid': 'https://orcid.org/0000-0001-6102-4661'}, 'institutions': [{'id': 'https://openalex.org/I4210146710', 'display_name': 'Mayo Clinic in Florida', 'ror': 'https://ror.org/03zzw1w08', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210146710']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard Joseph', 'raw_affiliation_strings': ['9Mayo Clinic Cancer Center, Jacksonville, FL;'], 'affiliations': [{'raw_affiliation_string': '9Mayo Clinic Cancer Center, Jacksonville, FL;', 'institution_ids': ['https://openalex.org/I4210146710']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109331981', 'display_name': 'Tara C. Gangadhar', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tara C. Gangadhar', 'raw_affiliation_strings': ['10Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA;'], 'affiliations': [{'raw_affiliation_string': '10Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA;', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027176998', 'display_name': 'Roxana Dronca', 'orcid': 'https://orcid.org/0000-0002-5345-2268'}, 'institutions': [{'id': 'https://openalex.org/I4210125099', 'display_name': 'Mayo Clinic in Arizona', 'ror': 'https://ror.org/03jp40720', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210125099']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Roxana S. Dronca', 'raw_affiliation_strings': ['11Mayo Clinic, Rochester, MN;'], 'affiliations': [{'raw_affiliation_string': '11Mayo Clinic, Rochester, MN;', 'institution_ids': ['https://openalex.org/I4210125099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070570779', 'display_name': 'Amita Patnaik', 'orcid': 'https://orcid.org/0000-0002-4144-2193'}, 'institutions': [{'id': 'https://openalex.org/I4210119066', 'display_name': 'South Texas Accelerated Research Therapeutics', 'ror': 'https://ror.org/01scs7915', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210119066']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Amita Patnaik', 'raw_affiliation_strings': ['12South Texas Accelerated Research Therapeutics (START), San Antonio, TX;'], 'affiliations': [{'raw_affiliation_string': '12South Texas Accelerated Research Therapeutics (START), San Antonio, TX;', 'institution_ids': ['https://openalex.org/I4210119066']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025286759', 'display_name': 'Hassane M. Zarour', 'orcid': 'https://orcid.org/0000-0003-2525-2688'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hassane Zarour', 'raw_affiliation_strings': ['13University of Pittsburgh, Pittsburgh, PA;'], 'affiliations': [{'raw_affiliation_string': '13University of Pittsburgh, Pittsburgh, PA;', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085333470', 'display_name': 'Anthony M. Joshua', 'orcid': 'https://orcid.org/0000-0001-5159-4580'}, 'institutions': [{'id': 'https://openalex.org/I2802654988', 'display_name': 'Princess Margaret Cancer Centre', 'ror': 'https://ror.org/03zayce58', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Anthony M. Joshua', 'raw_affiliation_strings': ['14Princess Margaret Cancer Centre, Toronto, Ontario, Canada;'], 'affiliations': [{'raw_affiliation_string': '14Princess Margaret Cancer Centre, Toronto, Ontario, Canada;', 'institution_ids': ['https://openalex.org/I2802654988']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072448285', 'display_name': 'Kevin Gergich', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Kevin Gergich', 'raw_affiliation_strings': ['15Merck, North Wales, PA;'], 'affiliations': [{'raw_affiliation_string': '15Merck, North Wales, PA;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086085318', 'display_name': 'Dianna Wu', 'orcid': 'https://orcid.org/0000-0002-4814-3620'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Dianna Wu', 'raw_affiliation_strings': ['15Merck, North Wales, PA;'], 'affiliations': [{'raw_affiliation_string': '15Merck, North Wales, PA;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061867713', 'display_name': 'Jared Lunceford', 'orcid': 'https://orcid.org/0000-0001-8120-2277'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jared K. Lunceford', 'raw_affiliation_strings': ['16Merck, Rahway, NJ;'], 'affiliations': [{'raw_affiliation_string': '16Merck, Rahway, NJ;', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062557677', 'display_name': 'Kenneth Emancipator', 'orcid': 'https://orcid.org/0000-0002-6629-4430'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kenneth Emancipator', 'raw_affiliation_strings': ['16Merck, Rahway, NJ;'], 'affiliations': [{'raw_affiliation_string': '16Merck, Rahway, NJ;', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084659842', 'display_name': 'Marisa Dolled‐Filhart', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Marisa Dolled-Filhart', 'raw_affiliation_strings': ['16Merck, Rahway, NJ;'], 'affiliations': [{'raw_affiliation_string': '16Merck, Rahway, NJ;', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084533214', 'display_name': 'Nicole Y. K. Li‐Jessen', 'orcid': 'https://orcid.org/0000-0003-2963-4763'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Nicole Li', 'raw_affiliation_strings': ['15Merck, North Wales, PA;'], 'affiliations': [{'raw_affiliation_string': '15Merck, North Wales, PA;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005775401', 'display_name': 'Scot Ebbinghaus', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Scot Ebbinghaus', 'raw_affiliation_strings': ['15Merck, North Wales, PA;'], 'affiliations': [{'raw_affiliation_string': '15Merck, North Wales, PA;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109399966', 'display_name': 'Soonmo Peter Kang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S. Peter Kang', 'raw_affiliation_strings': ['17Merck Research Laboratories, Kenilworth, NJ;'], 'affiliations': [{'raw_affiliation_string': '17Merck Research Laboratories, Kenilworth, NJ;', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100713900', 'display_name': 'Caroline Robert', 'orcid': 'https://orcid.org/0000-0002-9493-0238'}, 'institutions': [{'id': 'https://openalex.org/I2801843802', 'display_name': 'Institut Gustave Roussy', 'ror': 'https://ror.org/0321g0743', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2801843802']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Caroline Robert', 'raw_affiliation_strings': ['18Gustave Roussy, Villejuif, France.'], 'affiliations': [{'raw_affiliation_string': '18Gustave Roussy, Villejuif, France.', 'institution_ids': ['https://openalex.org/I2801843802']}]}], 'institution_assertions': [], 'countries_distinct_count': 4, 'institutions_distinct_count': 15, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.587, 'has_fulltext': False, 'cited_by_count': 36, 'citation_normalized_percentile': {'value': 0.840998, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '74', 'issue': '19_Supplement', 'first_page': 'CT104', 'last_page': 'CT104'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Monoclonal and Polyclonal Antibodies Research', 'score': 0.9943, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11491', 'display_name': 'CAR-T cell therapy research', 'score': 0.9875, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pharmacodynamics', 'display_name': 'Pharmacodynamics', 'score': 0.51727587}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7632178}, {'id': 'https://openalex.org/C542903549', 'wikidata': 'https://www.wikidata.org/wiki/Q422248', 'display_name': 'Monoclonal antibody', 'level': 3, 'score': 0.5766174}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.5301477}, {'id': 'https://openalex.org/C2777288759', 'wikidata': 'https://www.wikidata.org/wiki/Q4164182', 'display_name': 'Dosing', 'level': 2, 'score': 0.528152}, {'id': 'https://openalex.org/C111113717', 'wikidata': 'https://www.wikidata.org/wiki/Q725307', 'display_name': 'Pharmacodynamics', 'level': 3, 'score': 0.51727587}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.44012707}, {'id': 'https://openalex.org/C167672396', 'wikidata': 'https://www.wikidata.org/wiki/Q417800', 'display_name': 'CD8', 'level': 3, 'score': 0.4371706}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.4167132}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.32775384}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.27995768}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.26533896}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.17501822}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2014-ct104', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.47}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2410275474', 'https://openalex.org/W2366976950', 'https://openalex.org/W2353001009', 'https://openalex.org/W2123042378', 'https://openalex.org/W2074356812', 'https://openalex.org/W2038791604', 'https://openalex.org/W2033539097', 'https://openalex.org/W2004249573', 'https://openalex.org/W1999686187', 'https://openalex.org/W110523806'], 'abstract_inverted_index': {'Abstract': [0], 'Background:': [1], 'Previous': [2], 'data': [3], 'on': [4], 'the': [5, 114, 154, 207, 239, 305, 450, 468, 473], 'relationship': [6, 44], 'between': [7], 'PD-L1': [8, 40, 126, 144, 225, 269, 293, 319, 331, 460], 'expression': [9, 41, 127, 226, 270, 461], 'and': [10, 14, 35, 42, 148, 153, 162, 191, 201, 217, 245, 277, 317, 326, 328], 'activity': [11, 32, 285, 448], 'of': [12, 53, 65, 116, 135, 137, 156, 199, 241, 353, 363, 449, 458, 467, 472], 'anti-PD-1': [13, 451], 'anti-PD-L1': [15], 'antibodies': [16], 'have': [17], 'been': [18], 'conflicting.': [19], 'MK-3475,': [20], 'a': [21, 48, 62, 98, 231], 'humanized': [22], 'monoclonal': [23, 452], 'IgG4': [24], 'antibody': [25, 453], 'against': [26], 'PD-1,': [27], 'has': [28], 'demonstrated': [29], 'durable': [30], 'antitumor': [31], 'in': [33, 47, 166, 238, 279, 289, 304, 351, 361, 455], 'MEL': [34, 70, 280], 'NSCLC.': [36], 'We': [37, 55], 'evaluated': [38, 57], 'tumor': [39, 224, 275, 459], 'its': [43], 'with': [45, 210, 223, 274, 283, 291, 462], 'outcomes': [46], 'phase': [49], 'I': [50], 'clinical': [51], 'trial': [52], 'MK-3475.': [54], 'also': [56, 287], 'T': [58, 150, 164, 247, 301], 'cell': [59, 151, 302], 'activation': [60, 303], 'as': [61, 159], 'pharmacodynamic': [63], 'marker': [64], 'MK-3475': [66, 73, 385, 454], 'activity.': [67], 'Methods:': [68], '135': [69], 'pts': [71, 209, 281, 290], 'received': [72, 384], '10': [74, 77, 386], 'mg/kg': [75, 78, 82, 387], 'Q2W,': [76], 'Q3W,': [79], 'or': [80, 121], '2': [81], 'Q3W.': [83], 'Tumor': [84, 125, 268], 'response': [85, 200, 218, 276], 'was': [86, 104, 128, 140, 181, 189, 195, 214, 249, 286, 308], 'assessed': [87, 129, 170, 296], 'by': [88, 130, 171, 297], 'RECIST': [89], '1.1': [90], 'per': [91], 'independent': [92], 'central': [93], 'review,': [94], 'including': [95], 'requirement': [96], 'for': [97, 261, 265, 371, 476], 'confirmatory': [99], 'CT': [100], 'scan.': [101], 'Pretreatment': [102], 'biopsy': [103], 'required.': [105], 'Serial': [106], 'blood': [107, 168], 'samples': [108], 'were': [109, 169, 203, 220, 272], 'collected': [110], 'before': [111], 'infusion': [112], 'at': [113, 251, 310, 335, 342], 'start': [115], 'cycles': [117], '1-5': [118], '(Q2W': [119], 'dosing)': [120], '1-4': [122], '(Q3W': [123], 'dosing).': [124], 'IHC.': [131], 'A': [132], 'preliminary': [133], 'cutoff': [134], '1%': [136], 'stained': [138], 'cells': [139, 165, 248], 'used': [141], 'to': [142], 'define': [143], 'positivity.': [145], 'Absolute': [146], 'CD4+': [147, 161, 244], 'CD8+': [149, 163, 246], 'counts': [152], 'percentage': [155, 240], 'activated': [157, 242], '(HLA-DR': [158], 'marker)': [160], 'peripheral': [167], 'multiplex': [172], 'flow': [173], 'cytometry': [174], '(n': [175], '=': [176], '101).': [177], 'Results:': [178], 'Median': [179, 197], 'PFS': [180, 216, 278, 327], '36': [182], 'weeks,': [183], '6-month': [184], 'overall': [185], 'survival': [186], '(OS)': [187], 'rate': [188, 194, 219], '89%,': [190], '12-month': [192], 'OS': [193, 202, 329], '81%.': [196], 'duration': [198], 'not': [204], 'reached.': [205], 'In': [206], '116': [208], 'measurable': [211], 'disease,': [212], 'ORR': [213], '41%.': [215], 'significantly': [221], 'associated': [222, 273], '(Table).': [227], 'At': [228], 'week': [229], '6,': [230], 'statistically': [232], 'significant': [233], 'percent': [234, 256], 'increase': [235], 'from': [236], 'baseline': [237], '(HLA-DR+)': [243], 'observed': [250, 288], 'all': [252, 311], 'doses': [253, 312], '(pooled': [254], 'mean': [255], 'change': [257], '[SE],': [258], '+24.0%': [259], '[4.7%]': [260], 'HLA-DR+/CD8+,': [262], '+17.5%': [263], '[2.7%]': [264], 'HLA-DR+/CD4+).': [266], 'Conclusions:': [267], 'levels': [271], 'treated': [282], 'MK-3475;': [284], 'low': [292], 'expression.': [294], 'As': [295], 'HLA-DR': [298], 'expression,': [299], 'post-treatment': [300], 'circulating': [306], 'pool': [307], 'increased': [309], 'tested.': [313], 'Patients': [314], 'WithMeasurable': [315], 'Disease': [316], 'Interpretable': [318], 'IHC': [320, 324], 'ResultsPatients': [321], 'With': [322], 'InterpretablePD-L1': [323], 'Results': [325], 'Data': [330], 'TumorExpressionNORR,': [332], 'n': [333], '(%)NPFS': [334], '6': [336, 343], 'months,': [337, 344], '%': [338, 345], '(95%': [339, 346, 369], 'CI)Median': [340, 347], 'PFSOS': [341], 'OSPositive': [348], '(membrane': [349, 359], 'staining': [350, 360], '≥1%': [352], 'cells)5529': [354], '(53)6058': [355], '(47-72)10.6': [356], 'mo93(87-100)Not': [357], 'reachedNegative': [358], '&amp;lt;1%': [362], 'cells)161*': [364], '(6)2232': [365], '(16-64)2.9': [366], 'mo75(58-97)Not': [367], 'reachedHR': [368], 'CI)': [370], 'PD-L1-positive': [372], 'vs': [373], 'negative____0.54(0.28-1.05)_0.67(0.25-1.83)One-sidedP': [374], 'value(PD-L1': [375], 'association': [376], 'test)_&amp;lt;0.004': [377], '(logistic': [378], 'regression)__0.034(Cox': [379], 'regression)_0.220(Cox': [380], 'regression)*IPI-pretreated': [381], 'patient': [382], 'who': [383], 'Q2W.': [388], 'Citation': [389], 'Format:': [390], 'Adil': [391], 'I.': [392], 'Daud,': [393], 'Omid': [394], 'Hamid,': [395], 'Antoni': [396], 'Ribas,': [397], 'F.': [398], 'Stephen': [399], 'Hodi,': [400], 'Wen-Jen': [401], 'Hwu,': [402], 'Richard': [403, 412], 'Kefford,': [404], 'Jedd': [405], 'Wolchok,': [406], 'Peter': [407, 443], 'Hersey,': [408], 'Jeffrey': [409], 'S.': [410, 418, 442], 'Weber,': [411], 'Joseph,': [413], 'Tara': [414], 'C.': [415], 'Gangadhar,': [416], 'Roxana': [417], 'Dronca,': [419], 'Amita': [420], 'Patnaik,': [421], 'Hassane': [422], 'Zarour,': [423], 'Anthony': [424], 'M.': [425], 'Joshua,': [426], 'Kevin': [427], 'Gergich,': [428], 'Dianna': [429], 'Wu,': [430], 'Jared': [431], 'K.': [432], 'Lunceford,': [433], 'Kenneth': [434], 'Emancipator,': [435], 'Marisa': [436], 'Dolled-Filhart,': [437], 'Nicole': [438], 'Li,': [439], 'Scot': [440], 'Ebbinghaus,': [441], 'Kang,': [444], 'Caroline': [445], 'Robert.': [446], 'Antitumor': [447], 'melanoma(MEL):': [456], 'Correlation': [457], 'outcome.': [463], '[abstract].': [464], 'In:': [465], 'Proceedings': [466], '105th': [469], 'Annual': [470], 'Meeting': [471], 'American': [474], 'Association': [475], 'Cancer': [477, 488], 'Research;': [478], '2014': [479], 'Apr': [480], '5-9;': [481], 'San': [482], 'Diego,': [483], 'CA.': [484], 'Philadelphia': [485], '(PA):': [486], 'AACR;': [487], 'Res': [489], '2014;74(19': [490], 'Suppl):Abstract': [491], 'nr': [492], 'CT104.': [493], 'doi:10.1158/1538-7445.AM2014-CT104': [494]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2011044258', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 17}, {'year': 2014, 'cited_by_count': 6}], 'updated_date': '2024-12-08T13:13:51.001514', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
