The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B

Name: Work Video:
Duration: 3 min 30 s
Yan Zhang; Huirong Yang; Xue Guo; Naiyan Rong; Yujiao Song; Youwei Xu; Wenxian Lan; Xu Zhang; Maili Liu; Yanhui Xu; Chunyang Cao
{'id': 'https://openalex.org/W2011006223', 'doi': 'https://doi.org/10.1007/s13238-014-0078-4', 'title': 'The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B', 'display_name': 'The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B', 'publication_year': 2014, 'publication_date': '2014-06-21', 'ids': {'openalex': 'https://openalex.org/W2011006223', 'doi': 'https://doi.org/10.1007/s13238-014-0078-4', 'mag': '2011006223', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24952722', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4225485'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s13238-014-0078-4', 'pdf_url': 'https://academic.oup.com/proteincell/article-pdf/5/11/837/48347754/13238_2014_article_78.pdf', 'source': {'id': 'https://openalex.org/S126440360', 'display_name': 'Protein & Cell', 'issn_l': '1674-800X', 'issn': ['1674-800X', '1674-8018'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'diamond', 'oa_url': 'https://academic.oup.com/proteincell/article-pdf/5/11/837/48347754/13238_2014_article_78.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100456393', 'display_name': 'Yan Zhang', 'orcid': 'https://orcid.org/0000-0003-2189-0244'}, 'institutions': [{'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yan Zhang', 'raw_affiliation_strings': ['Chinese Academy of Sciences'], 'affiliations': [{'raw_affiliation_string': 'Chinese Academy of Sciences', 'institution_ids': ['https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101828781', 'display_name': 'Huirong Yang', 'orcid': 'https://orcid.org/0000-0002-5884-9088'}, 'institutions': [{'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Huirong Yang', 'raw_affiliation_strings': ['Fudan University'], 'affiliations': [{'raw_affiliation_string': 'Fudan University', 'institution_ids': ['https://openalex.org/I24943067']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100951090', 'display_name': 'Xue Guo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xue Guo', 'raw_affiliation_strings': ['Fudan University'], 'affiliations': [{'raw_affiliation_string': 'Fudan University', 'institution_ids': ['https://openalex.org/I24943067']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041375191', 'display_name': 'Naiyan Rong', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Naiyan Rong', 'raw_affiliation_strings': ['Chinese Academy of Sciences'], 'affiliations': [{'raw_affiliation_string': 'Chinese Academy of Sciences', 'institution_ids': ['https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102211141', 'display_name': 'Yujiao Song', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yujiao Song', 'raw_affiliation_strings': ['Chinese Academy of Sciences'], 'affiliations': [{'raw_affiliation_string': 'Chinese Academy of Sciences', 'institution_ids': ['https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028310890', 'display_name': 'Youwei Xu', 'orcid': 'https://orcid.org/0000-0001-8069-7511'}, 'institutions': [{'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Youwei Xu', 'raw_affiliation_strings': ['Fudan University'], 'affiliations': [{'raw_affiliation_string': 'Fudan University', 'institution_ids': ['https://openalex.org/I24943067']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102328898', 'display_name': 'Wenxian Lan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wenxian Lan', 'raw_affiliation_strings': ['Chinese Academy of Sciences'], 'affiliations': [{'raw_affiliation_string': 'Chinese Academy of Sciences', 'institution_ids': ['https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100437279', 'display_name': 'Xu Zhang', 'orcid': 'https://orcid.org/0000-0002-9817-4492'}, 'institutions': [{'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xu Zhang', 'raw_affiliation_strings': ['Chinese Academy of Sciences'], 'affiliations': [{'raw_affiliation_string': 'Chinese Academy of Sciences', 'institution_ids': ['https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016279721', 'display_name': 'Maili Liu', 'orcid': 'https://orcid.org/0000-0002-9359-915X'}, 'institutions': [{'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Maili Liu', 'raw_affiliation_strings': ['Chinese Academy of Sciences'], 'affiliations': [{'raw_affiliation_string': 'Chinese Academy of Sciences', 'institution_ids': ['https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006716123', 'display_name': 'Yanhui Xu', 'orcid': 'https://orcid.org/0000-0002-1408-5178'}, 'institutions': [{'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yanhui Xu', 'raw_affiliation_strings': ['Fudan University'], 'affiliations': [{'raw_affiliation_string': 'Fudan University', 'institution_ids': ['https://openalex.org/I24943067']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108693061', 'display_name': 'Chunyang Cao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chunyang Cao', 'raw_affiliation_strings': ['Chinese Academy of Sciences'], 'affiliations': [{'raw_affiliation_string': 'Chinese Academy of Sciences', 'institution_ids': ['https://openalex.org/I19820366']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 0, 'currency': 'USD', 'value_usd': 0, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.349, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 70, 'citation_normalized_percentile': {'value': 0.871928, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '5', 'issue': '11', 'first_page': '837', 'last_page': '850'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13157', 'display_name': 'Cancer-related gene regulation', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11736', 'display_name': 'Histone Deacetylase Inhibitors Research', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/demethylase', 'display_name': 'Demethylase', 'score': 0.93541694}, {'id': 'https://openalex.org/keywords/demethylation', 'display_name': 'Demethylation', 'score': 0.8398365}], 'concepts': [{'id': 'https://openalex.org/C2781364455', 'wikidata': 'https://www.wikidata.org/wiki/Q2531584', 'display_name': 'Demethylase', 'level': 4, 'score': 0.93541694}, {'id': 'https://openalex.org/C202199734', 'wikidata': 'https://www.wikidata.org/wiki/Q900386', 'display_name': 'Demethylation', 'level': 5, 'score': 0.8398365}, {'id': 'https://openalex.org/C64927066', 'wikidata': 'https://www.wikidata.org/wiki/Q36293', 'display_name': 'Histone', 'level': 3, 'score': 0.6961787}, {'id': 'https://openalex.org/C186310378', 'wikidata': 'https://www.wikidata.org/wiki/Q941796', 'display_name': 'Psychological repression', 'level': 4, 'score': 0.5496975}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.48138574}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.47293925}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.4582455}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4559321}, {'id': 'https://openalex.org/C179185449', 'wikidata': 'https://www.wikidata.org/wiki/Q219699', 'display_name': 'Suppressor', 'level': 3, 'score': 0.44816068}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.35129195}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.1744313}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.16329604}], 'mesh': [{'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D056484', 'descriptor_name': 'Jumonji Domain-Containing Histone Demethylases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008239', 'descriptor_name': 'Lysine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018360', 'descriptor_name': 'Crystallography, X-Ray', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056484', 'descriptor_name': 'Jumonji Domain-Containing Histone Demethylases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056484', 'descriptor_name': 'Jumonji Domain-Containing Histone Demethylases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D056484', 'descriptor_name': 'Jumonji Domain-Containing Histone Demethylases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008239', 'descriptor_name': 'Lysine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008239', 'descriptor_name': 'Lysine', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009682', 'descriptor_name': 'Magnetic Resonance Spectroscopy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008745', 'descriptor_name': 'Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008856', 'descriptor_name': 'Microscopy, Fluorescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s13238-014-0078-4', 'pdf_url': 'https://academic.oup.com/proteincell/article-pdf/5/11/837/48347754/13238_2014_article_78.pdf', 'source': {'id': 'https://openalex.org/S126440360', 'display_name': 'Protein & Cell', 'issn_l': '1674-800X', 'issn': ['1674-800X', '1674-8018'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4225485', 'pdf_url': 'https://europepmc.org/articles/pmc4225485?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225485', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24952722', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s13238-014-0078-4', 'pdf_url': 'https://academic.oup.com/proteincell/article-pdf/5/11/837/48347754/13238_2014_article_78.pdf', 'source': {'id': 'https://openalex.org/S126440360', 'display_name': 'Protein & Cell', 'issn_l': '1674-800X', 'issn': ['1674-800X', '1674-8018'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.62, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 59, 'referenced_works': ['https://openalex.org/W1485670237', 'https://openalex.org/W1589295940', 'https://openalex.org/W1963789736', 'https://openalex.org/W1964392627', 'https://openalex.org/W1965547460', 'https://openalex.org/W1970203449', 'https://openalex.org/W1970205781', 'https://openalex.org/W1975459052', 'https://openalex.org/W1981452104', 'https://openalex.org/W1985180051', 'https://openalex.org/W1986191025', 'https://openalex.org/W1986823131', 'https://openalex.org/W1992530782', 'https://openalex.org/W1992538495', 'https://openalex.org/W2001113618', 'https://openalex.org/W2001147303', 'https://openalex.org/W2002195659', 'https://openalex.org/W2002676132', 'https://openalex.org/W2003314433', 'https://openalex.org/W2004499293', 'https://openalex.org/W2006410633', 'https://openalex.org/W2010982295', 'https://openalex.org/W2012935454', 'https://openalex.org/W2017840637', 'https://openalex.org/W2023997559', 'https://openalex.org/W2030692354', 'https://openalex.org/W2054643318', 'https://openalex.org/W2059059097', 'https://openalex.org/W2059255388', 'https://openalex.org/W2063756611', 'https://openalex.org/W2065055008', 'https://openalex.org/W2066305078', 'https://openalex.org/W2067523496', 'https://openalex.org/W2068157186', 'https://openalex.org/W2069157717', 'https://openalex.org/W2072645668', 'https://openalex.org/W2080653870', 'https://openalex.org/W2086184439', 'https://openalex.org/W2094880341', 'https://openalex.org/W2097081350', 'https://openalex.org/W2106134616', 'https://openalex.org/W2106919678', 'https://openalex.org/W2110399580', 'https://openalex.org/W2111390374', 'https://openalex.org/W2115525854', 'https://openalex.org/W2118240383', 'https://openalex.org/W2120702938', 'https://openalex.org/W2125765631', 'https://openalex.org/W2127732469', 'https://openalex.org/W2128438064', 'https://openalex.org/W2132614547', 'https://openalex.org/W2139008292', 'https://openalex.org/W2144806790', 'https://openalex.org/W2150609732', 'https://openalex.org/W2158562032', 'https://openalex.org/W2163078458', 'https://openalex.org/W2169821755', 'https://openalex.org/W4212766227', 'https://openalex.org/W4236258478'], 'related_works': ['https://openalex.org/W4362418054', 'https://openalex.org/W4362240445', 'https://openalex.org/W4361954948', 'https://openalex.org/W3193659375', 'https://openalex.org/W2939267646', 'https://openalex.org/W2070246829', 'https://openalex.org/W2047179371', 'https://openalex.org/W2030397414', 'https://openalex.org/W2015316225', 'https://openalex.org/W2011006223'], 'abstract_inverted_index': {'KDM5B': [0, 10, 82, 108], 'is': [1, 11, 24, 51], 'a': [2], 'histone': [3], 'H3K4me2/3': [4, 78], 'demethylase.': [5], 'The': [6, 61], 'PHD1': [7], 'domain': [8, 23], 'of': [9, 21, 40, 56, 63, 81, 93, 117], 'critical': [12], 'for': [13], 'demethylation,': [14], 'but': [15], 'the': [16, 19, 48, 70, 73, 77, 90, 114], 'mechanism': [17], 'underlying': [18], 'action': [20], 'this': [22, 27, 64], 'unclear.': [25], 'In': [26], 'paper,': [28], 'we': [29], 'observed': [30], 'that': [31, 47, 55, 103], 'PHD1KDM5B': [32, 41, 104], 'interacts': [33], 'with': [34, 44], 'unmethylated': [35], 'H3K4me0.': [36], 'Our': [37], 'NMR': [38], 'structure': [39], 'in': [42, 72, 83], 'complex': [43], 'H3K4me0': [45], 'revealed': [46], 'binding': [49], 'mode': [50], 'slightly': [52], 'different': [53], 'from': [54], 'other': [57], 'reported': [58], 'PHD': [59], 'fingers.': [60], 'disruption': [62], 'interaction': [65], 'by': [66, 85, 97], 'double': [67], 'mutations': [68], 'on': [69], 'residues': [71], 'interface': [74], '(L325A/D328A)': [75], 'decreases': [76], 'demethylation': [79, 115], 'activity': [80], 'cells': [84], 'approximately': [86, 98], '50%': [87], 'and': [88], 'increases': [89], 'transcriptional': [91], 'repression': [92], 'tumor': [94], 'suppressor': [95], 'genes': [96, 111], 'twofold.': [99], 'These': [100], 'findings': [101], 'imply': [102], 'may': [105], 'help': [106], 'maintain': [107], 'at': [109], 'target': [110], 'to': [112], 'mediate': [113], 'activities': [116], 'KDM5B.': [118]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2011006223', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 8}], 'updated_date': '2024-12-14T04:12:11.610778', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
