Abstract: Enteropathogenic Escherichia coli (EPEC) is a major cause of diarrhea in young children. EPEC and its related pathogens use a unique virulence mechanism known as attaching and effacing (A/E), which involves the intimate attachment of bacteria to the epithelial surface and the effacement of host cell microvilli. All of the genes necessary for A/E, including those encoding the type III secretion system (TTSS), are encoded on a 35-kb chromosomal pathogenicity island known as the locus of enterocyte effacement (LEE). Although extensive information has been obtained about the EPEC TTSS and the EspA filament, the supermolecular structure of the TTSS and its relationship to the EspA filament are poorly understood. Recently, this was clarified by Sekiya and collaborators 1 Sekiya K. et al. Supermolecular structure of the enteropathogenic Escherichia coli type III secretion system and its direct interaction with the EspA-sheath-like structure. Proc. Natl. Acad. Sci. U. S. A. 2001; 98: 11638-11643 Crossref PubMed Scopus (249) Google Scholar .
Publication Year: 2001
Publication Date: 2001-12-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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