Publication Information

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49, 59, 109, 132, 168, 236, 268, 278, 328, 351, 387, 516, 674, 688, 697, 789, 800, 821, 825, 981, 1029, 1044, 1081, 1228, 1277, 1297, 1463, 1513, 1532, 1535, 1611, 1760, 1777, 1795, 1830, 1913, 2089, 2194, 2225, 2246, 2313, 2339, 2361, 2390, 2472, 2587, 2674, 2755, 2809, 2821, 2839, 2852, 2871, 2903, 2922, 2976, 3002, 3009, 3042, 3114, 3120, 3144, 3172, 3223, 3394, 3409, 3423, 3446, 3483, 3497, 3519, 3544, 3548, 3552, 3643, 3723, 3734, 3752, 3763, 3775, 3823, 3839, 4032, 4046, 4068, 4230, 4245, 4311, 4397, 4482, 4488, 4497, 4547, 4574, 4602, 4659, 4745, 4772, 4805, 5071, 5096, 5155, 5307, 5315, 5379, 5411, 5519, 5567, 5609, 5636, 5689, 5702, 5795, 5886, 5999, 6044, 6066, 6068, 6100, 6159, 6211], 'the': [18, 60, 66, 80, 204, 237, 279, 285, 299, 423, 453, 457, 509, 517, 566, 576, 632, 675, 707, 801, 810, 848, 879, 937, 961, 995, 1001, 1018, 1030, 1050, 1082, 1232, 1263, 1395, 1466, 1490, 1563, 1567, 1620, 1639, 1666, 1672, 1676, 1685, 1706, 1751, 1770, 1810, 1831, 1857, 1929, 1965, 2013, 2065, 2074, 2119, 2217, 2247, 2257, 2293, 2304, 2328, 2331, 2336, 2340, 2345, 2362, 2367, 2370, 2382, 2391, 2497, 2523, 2538, 2542, 2563, 2786, 2800, 2806, 2822, 2862, 2876, 2908, 2928, 2978, 3047, 3075, 3080, 3112, 3118, 3132, 3138, 3147, 3170, 3241, 3249, 3336, 3347, 3354, 3370, 3387, 3432, 3437, 3447, 3495, 3498, 3501, 3508, 3549, 3553, 3587, 3647, 3657, 3661, 3691, 3758, 3768, 3792, 3811, 3816, 3820, 3824, 3829, 3851, 3854, 3915, 4064, 4088, 4095, 4125, 4132, 4168, 4180, 4202, 4237, 4240, 4254, 4265, 4276, 4281, 4296, 4312, 4322, 4337, 4389, 4398, 4405, 4531, 4549, 4575, 4580, 4603, 4620, 4660, 4682, 4707, 4811, 4910, 4938, 4941, 4966, 4971, 5065, 5110, 5146, 5250, 5281, 5298, 5355, 5363, 5552, 5596, 5623, 5642, 5665, 5685, 5707, 5787, 5866, 5874, 5891, 6000, 6045, 6093, 6157, 6190, 6212], 'treatment': [19, 238, 676, 834, 1541, 1755, 2080, 2892, 3750, 3874, 4074, 4467, 4533, 4604, 5127], 'of': [20, 31, 62, 82, 92, 126, 141, 155, 174, 187, 212, 239, 250, 281, 301, 311, 345, 360, 374, 393, 406, 431, 443, 452, 456, 464, 519, 568, 578, 634, 677, 803, 835, 850, 881, 939, 975, 1032, 1073, 1084, 1398, 1465, 1492, 1510, 1529, 1551, 1566, 1638, 1675, 1708, 1713, 1773, 1784, 1820, 1828, 1846, 1851, 1909, 1923, 1964, 2015, 2020, 2024, 2100, 2131, 2139, 2259, 2330, 2358, 2369, 2409, 2479, 2486, 2534, 2541, 2548, 2562, 2575, 2645, 2672, 2677, 2753, 2767, 2814, 2824, 2833, 2861, 2878, 2918, 2936, 2980, 2996, 3117, 3169, 3243, 3246, 3251, 3420, 3436, 3449, 3480, 3488, 3500, 3514, 3555, 3579, 3589, 3593, 3650, 3675, 3719, 3756, 3770, 3794, 3819, 3826, 3853, 3859, 3879, 4013, 4020, 4058, 4082, 4090, 4098, 4127, 4138, 4149, 4157, 4167, 4172, 4182, 4204, 4216, 4223, 4256, 4283, 4298, 4333, 4407, 4410, 4494, 4504, 4563, 4582, 4585, 4605, 4613, 4623, 4740, 4794, 4815, 4886, 4940, 4945, 4958, 4968, 5138, 5161, 5236, 5252, 5268, 5485, 5598, 5644, 5663, 5789, 5904, 6104, 6180, 6192], 'epilepsy': [21, 240, 678, 4606], 'and': [22, 42, 105, 124, 202, 241, 261, 324, 343, 421, 477, 522, 547, 626, 638, 679, 687, 783, 884, 934, 988, 1262, 1296, 1462, 1488, 1694, 1848, 1856, 1875, 1878, 1892, 1917, 1994, 2003, 2091, 2156, 2209, 2239, 2289, 2326, 2348, 2376, 2415, 2456, 2483, 2544, 2568, 2654, 2789, 2799, 2998, 3051, 3192, 3227, 3282, 3369, 3386, 3413, 3634, 3866, 4036, 4121, 4136, 4162, 4185, 4191, 4218, 4234, 4236, 4293, 4475, 4491, 4537, 4607, 4716, 4889, 4897, 4925, 4933, 4964, 5049, 5151, 5258, 5270, 5478, 5692, 5751, 5786, 5898, 5957, 6023, 6055, 6096, 6214], 'as': [23, 191, 242, 410, 450, 530, 683, 779, 1049, 1934, 2401, 2423, 2462, 2520, 2586, 2621, 2780, 3296, 3399, 3453, 4053, 4463, 4481, 4584, 5224, 5235, 5374, 5706, 5890, 5907, 6036, 6038, 6052, 6186], 'mood': [25, 244, 685], 'stabilizer,': [26, 245], 'triggers': [27, 246, 2932], 'replication-independent': [28, 247, 4647, 5638], 'active': [29, 77, 97, 248, 296, 316, 1405, 1564, 1636, 1692, 1709, 1757, 2933, 2969, 3486, 3676, 4550, 4770, 4781, 4884, 5266, 5376], 'demethylation': [30, 78, 99, 152, 249, 297, 318, 371, 1021, 1078, 1406, 1637, 1686, 1693, 1710, 1759, 2019, 2254, 2397, 2935, 3230, 3250, 3310, 3422, 3487, 3572, 3755, 4005, 4012, 4066, 4097, 4133, 4161, 4197, 4399, 4507, 4551, 4558, 4771, 4885, 4903, 4954, 5054, 5097, 5204, 5267, 5277, 5364, 5484, 5597, 5611, 5659], 'DNA.': [32, 251, 1495, 2214, 4972], 'Thus,': [33, 252, 2899, 4087, 5620, 5674], 'can': [36, 255, 705, 876, 1079, 1407, 3406, 3875, 4656, 4779, 5302, 5781], 'potentially': [37, 256, 4633], 'reverse': [38, 257, 1041], 'DNA': [39, 48, 83, 86, 98, 103, 106, 122, 207, 213, 258, 267, 302, 305, 317, 322, 325, 341, 426, 432, 438, 444, 473, 574, 843, 894, 971, 978, 1002, 1012, 1033, 1042, 1063, 1066, 1077, 1223, 1275, 1516, 1552, 1555, 1683, 1758, 1775, 1822, 2124, 2283, 2307, 2934, 2979, 3256, 3267, 3331, 3373, 3393, 3510, 3565, 3677, 4294, 4338, 4683, 4698, 4710, 4722, 4731, 4893, 5269, 5568, 5633, 5883, 6007, 6022, 6025, 6040, 6193, 6209], 'methylation': [40, 45, 84, 104, 208, 259, 264, 303, 323, 427, 439, 513, 844, 895, 979, 1003, 1043, 1064, 1509, 1553, 1776, 1880, 3270, 3389, 3692, 3732, 3818, 4684, 4699, 4711, 4723, 4732, 4943, 5569, 5634, 5884, 6194, 6210], 'patterns': [41, 260, 980, 4724, 5635, 5885], 'erase': [43, 262, 1508, 5632], 'stable': [44, 263], 'imprints': [46, 265], 'on': [47, 199, 266, 418, 1769, 2018, 2151, 3084, 3131, 3248, 3564, 3575, 3850, 4114, 4206, 4289, 4906, 5283], 'non-dividing': [50, 269, 983, 1045, 1778, 5796, 6216], 'cells.': [51, 114, 270, 333, 1762, 2103], 'Recent': [52, 271, 691], 'discoveries': [53, 272], 'support': [54, 183, 273, 402, 795, 3660, 5137, 5873], 'role': [56, 275, 797], 'VPA': [58, 118, 142, 190, 277, 337, 361, 409, 799, 875, 935, 964, 1469, 1497, 1754, 1969, 1993, 2457, 2829, 2896, 2900, 2914, 2931, 3247, 3481, 3517, 3561, 3590, 3641, 3749, 3865, 3873, 3997, 4016, 4091, 4128, 4152, 4194, 4205, 4227, 4252, 4279, 4402, 4510, 4589, 4640, 4655, 4778, 4791, 4816, 4882, 4936, 4952, 4980, 5075, 5116, 5130, 5162, 5221, 5248, 5262, 5306, 5341, 5621, 5780, 5877, 6155], 'regulation': [61, 280, 802], 'methylated': [63, 129, 161, 282, 348, 380, 494, 573, 579, 588, 804, 824, 1264, 1613, 1681, 1794, 1868, 2277, 2281, 2349, 2487, 2837, 2864, 2880, 2911, 2939, 3037, 3083, 3150, 3252, 3265, 3371, 3489, 3543, 3728, 3742, 3759, 3800, 3830, 3991, 4040, 4183, 4217, 4241, 4257, 4284, 4303, 4418, 4642, 4799, 4888, 5147, 5253, 5299, 5409, 5790], 'genes;': [64, 283], 'however,': [65, 284, 5590, 6061], 'mechanism': [67, 186, 286, 405, 564, 4630, 6032], 'unclear': [70, 289, 5216], 'because': [71, 290], 'it': [72, 291, 1036, 1481, 1502, 1628, 1680, 3125, 3177, 3359, 3804, 4000, 4688, 4693, 5120, 5140, 5231, 5404, 5602, 6161, 6174, 6199], 'is': [73, 209, 292, 428, 440, 511, 680, 819, 823, 852, 985, 999, 1005, 1017, 1470, 1523, 1542, 1616, 1679, 1691, 2290, 2308, 2354, 2398, 2867, 2901, 3082, 3142, 3149, 3187, 3232, 3360, 3416, 3492, 3573, 3598, 3672, 3779, 3790, 3846, 4006, 4042, 4085, 4140, 4228, 4243, 4300, 4395, 4590, 4712, 4804, 4904, 4914, 5061, 5106, 5108, 5121, 5215, 5312, 5349, 5360, 5405, 5481, 5557, 5603, 5607, 5622, 5653, 5661, 5700, 6014, 6089, 6162, 6175], 'difficult': [74, 293], 'to': [75, 294, 505, 572, 631, 699, 776, 892, 969, 1040, 1054, 1272, 1473, 1494, 1506, 1525, 1603, 1704, 1749, 2073, 2149, 2159, 2292, 2356, 2536, 2557, 2642, 2656, 2747, 2749, 2805, 2942, 3127, 3179, 3194, 3275, 3307, 3431, 3443, 3507, 3524, 3585, 3668, 3798, 3877, 4063, 4094, 4129, 4260, 4302, 4336, 4393, 4477, 4568, 4618, 4681, 4775, 4970, 4983, 5091, 5115, 5210, 5241, 5280, 5372, 5407, 5515, 5628, 5631, 5651, 5859, 5881, 5996, 6018, 6091, 6177, 6188, 6203], 'dissociate': [76, 295], 'from': [79, 101, 298, 320, 1231, 1549, 1787, 1887, 2107, 2114, 2617, 3259, 3805], 'absence': [81, 300, 1031, 1083, 3448, 3554], 'during': [85, 304, 1065, 1554, 1671, 6027], 'synthesis.': [87, 306, 1067], 'We': [88, 115, 307, 334, 1573, 1698, 2321, 2364, 3033, 3679, 4008, 4385, 4737, 4949], 'therefore': [89, 308, 4009, 5122], 'took': [90, 309, 4738], 'advantage': [91, 310, 4739, 6158, 6179], 'an': [93, 127, 139, 312, 346, 358, 461, 787, 889, 1006, 1475, 1562, 1571, 1610, 1863, 1999, 2572, 2745, 2944, 2994, 3600, 3673, 3685, 4422, 4460, 4518, 4741, 4916, 5375, 6164], 'assay': [94, 313, 1690, 1703, 1748, 2255, 2501, 3584, 4742, 5657], 'measures': [96, 315, 2256, 4769, 5658], 'independently': [100, 319], 'other': [102, 321, 701, 3133, 4583, 4702, 6039, 6048, 6215], 'replication': [107, 214, 326, 433, 1027, 1517, 2997, 3116], 'activities': [108, 327], 'human': [110, 329, 1233, 1621], 'embryonal': [111, 330, 1622, 1895], 'kidney': [112, 331, 1623, 1896], '293': [113, 332, 1898, 2102, 2116, 2468, 2619, 3004, 3044, 3225, 3261, 3426, 3737, 4049, 4413, 5667], 'show': [116, 335, 2855, 4880, 5246, 5346], 'induces': [119, 338, 1635, 1756, 2830, 4253, 4280, 4792, 5249], 'histone': [120, 147, 200, 339, 366, 419, 600, 604, 624, 711, 1414, 1486, 1633, 1714, 2512, 2831, 2905, 3434, 3450, 3670, 3884, 4109, 4291, 4329, 4907, 4986, 5226, 5784], 'acetylation,': [121, 148, 340, 367, 4110], 'demethylation,': [123, 342, 1547, 2970, 3522, 3646, 4158, 4295, 5353], 'expression': [125, 154, 344, 373, 479, 849, 938, 2031, 4021, 4084, 4137, 4150, 4163, 4255, 4282, 4425, 5251, 5285, 5480, 5788], 'ectopically': [128, 347, 2836, 4887], 'CMV-GFP': [130, 349, 1614, 1924, 2075, 2170, 2260, 2359, 2386, 2815, 2838, 2881, 2912, 2921, 2989, 3038, 3186, 3219, 3253, 3266, 3392, 3421, 3729, 3764, 3861, 4014, 4041, 4083, 4099, 4139, 4184, 4187, 4225, 4258, 4800, 4892, 4946, 4963, 5254], 'plasmid': [131, 350, 1615, 1640, 1667, 1821, 1869, 2032, 2990, 3119, 3171, 4242], 'dose-dependent': [134, 353, 3485, 4080], 'manner.': [135, 354], 'contrast,': [137, 356, 3745, 5507], 'valpromide,': [138, 357], 'analogue': [140, 359, 3595, 4911], 'does': [144, 149, 363, 368, 1518, 1668, 2274, 2984, 2991, 3039, 3135, 3220, 3538, 3562, 4106, 4694], 'not': [145, 150, 364, 369, 1519, 1669, 1695, 2275, 2985, 2992, 3000, 3040, 3106, 3136, 3221, 3361, 3539, 3599, 3780, 3786, 4002, 4107, 4199, 4690, 4915, 5338, 5563, 5594, 5677], 'induce': [146, 151, 365, 370, 936, 3669, 4101, 4108, 4657, 4984, 5782], 'or': [153, 372, 846, 1410, 1534, 1560, 1926, 1977, 1987, 2064, 2142, 2742, 3350, 3551, 3836, 3965, 4159, 4459, 4579, 4700, 4733, 5229, 5798], 'CMV-GFP.': [156, 375, 4220], 'Furthermore,': [157, 376, 5273, 5774], 'illustrate': [159, 378, 4901], 'DNA-binding': [162, 381, 580, 589, 1265], 'protein': [163, 382, 817, 1266, 2754, 2808, 3797, 4060, 4116], '2/DNA': [164, 383, 1267], 'demethylase': [165, 194, 384, 413, 1224, 1268, 1396, 1493, 3444, 3855, 4334, 4391, 4969, 5358, 5377, 5517, 5646], '(MBD2/dMTase)': [166, 385, 1269], 'participates': [167, 386], 'reaction': [170, 389, 1858], 'since': [171, 390, 3300, 4909, 5901], 'antisense': [172, 391, 2030, 4408, 4424, 4502, 4532, 4561], 'knockdown': [173, 392, 2017, 4409, 4503, 4562, 4571], 'MBD2/dMTase': [175, 394, 2016, 4305, 4505, 4523, 4543, 4564, 5348, 5368, 5606, 5699], 'attenuates': [176, 395], 'VPA-induced': [177, 396, 5352], 'demethylation.': [178, 397, 972, 1697, 3678, 3806, 4648, 4736, 4782, 5243, 5343, 5693], 'Taken': [179, 398, 4269], 'together,': [180, 399, 4270], 'our': [181, 400, 1229, 2840, 3545, 3583, 3682, 4271, 4746, 5104, 5618, 5656, 5871], 'data': [182, 401, 692, 957, 1764, 3183, 3659, 4272, 4540, 4932, 5289, 5872], 'new': [185, 404], 'action': [188, 407, 4614], 'enhancing': [192, 411], 'intracellular': [193, 412], 'activity': [195, 414, 1225, 1397, 4171, 4814, 5359, 5518], 'through': [196, 415, 3665, 4286], 'its': [197, 416, 700, 3594, 3666, 3731, 4018, 4143, 4287, 5479], 'effects': [198, 417, 2014, 3242, 3588, 4166, 4203, 4288, 4622, 5282, 6170], 'acetylation': [201, 420, 1415, 1487, 1634, 1715, 2832, 2906, 3435, 3885, 4292, 4330, 4793, 4908, 4957, 4987, 5785], 'raises': [203, 422], 'possibility': [205, 424, 962, 5875], 'reversible': [210, 429, 4714], 'independent': [211, 430, 2411, 3686, 4165, 5662], 'by': [215, 434, 709, 830, 838, 887, 1011, 1061, 1412, 1484, 1499, 1545, 1561, 1570, 1682, 1688, 1711, 1872, 1883, 1983, 2079, 2134, 2310, 2381, 2495, 2522, 2776, 3341, 3494, 3684, 3864, 3882, 3996, 4015, 4151, 4226, 4316, 4328, 4401, 4403, 4509, 4511, 4528, 4530, 4553, 4644, 4696, 4701, 4729, 4734, 4955, 5305, 5366, 5640, 6002, 6195, 6208], 'commonly': [216, 435], 'prescribed': [217, 436], 'drugs.': [218, 437], 'modification': [442], 'whereby': [445], 'methyl': [446, 1568], 'groups': [447, 1343, 5509], 'are': [448, 496, 1070, 3785, 3993, 4164, 4273, 4981, 5112, 5153, 5290, 5671, 5857, 6059, 6063, 6171], 'added': [449, 2072], 'part': [451, 3852], 'covalent': [454], 'structure': [455, 4325], 'genome,': [458], 'thus': [459, 785, 2399], 'providing': [460], 'extra': [462], 'layer': [463], 'epigenetic': [465], 'information.': [466], 'A': [467, 781, 4035, 4513, 5257], 'well': [468, 4592, 6037, 6181], 'documented': [469], 'relationship': [470], 'exists': [471], 'between': [472, 1605], 'methylation,': [474], 'chromatin': [475, 616, 627, 641, 4324, 5690], 'structure,': [476], 'gene': [478, 790, 1531, 2866, 4102, 5271, 5284, 5301], '(1Razin': [480], 'A.': [481, 655, 751, 915, 922, 1088, 1133, 1140, 1158, 1185, 1253, 1361, 1381, 2034, 4429, 4854, 5025, 5187, 5194, 5395, 5457, 5540, 5579, 5823, 5830, 5910, 5978, 5985, 6124, 6145], 'EMBO': [482, 765, 4868, 5039], 'J.': [483, 726, 766, 946, 1109, 1150, 1166, 1190, 1304, 1323, 1326, 1375, 1420, 1446, 1584, 1645, 1726, 1938, 1943, 2053, 2435, 2593, 2629, 2951, 3017, 3057, 3201, 3315, 3462, 3615, 3701, 3898, 3931, 3955, 4343, 4369, 4448, 4670, 4752, 4829, 4869, 5000, 5040, 5324, 5418, 5437, 5440, 5462, 5573, 5716, 5729, 5735, 5844, 5942], '1998;': [484, 657, 3982], '17:': [485], '4905-4908Crossref': [486], 'PubMed': [487, 542, 557, 660, 737, 770, 870, 926, 951, 1099, 1119, 1144, 1177, 1201, 1215, 1257, 1291, 1315, 1337, 1367, 1387, 1431, 1457, 1595, 1656, 1737, 1952, 2059, 2446, 2604, 2638, 2962, 3028, 3068, 3097, 3163, 3212, 3326, 3473, 3626, 3712, 3909, 3942, 3960, 3985, 4354, 4380, 4454, 4677, 4763, 4840, 4873, 5011, 5044, 5083, 5198, 5329, 5399, 5429, 5451, 5473, 5501, 5546, 5585, 5723, 5746, 5769, 5834, 5849, 5918, 5952, 5989, 6080, 6149], 'Scopus': [488, 543, 558, 661, 738, 771, 871, 927, 952, 1100, 1120, 1145, 1178, 1202, 1216, 1258, 1292, 1316, 1338, 1368, 1388, 1432, 1458, 1596, 1657, 1738, 2060, 2447, 2605, 2963, 3029, 3069, 3098, 3164, 3213, 3327, 3474, 3627, 3713, 3910, 3943, 3961, 3986, 4355, 4381, 4455, 4764, 4841, 4874, 5012, 5045, 5084, 5199, 5330, 5400, 5430, 5452, 5474, 5502, 5547, 5586, 5724, 5747, 5770, 5835, 5850, 5919, 5953, 5990, 6081, 6150], '(661)': [489], 'Google': [490, 545, 560, 663, 740, 773, 873, 929, 954, 1102, 1122, 1147, 1180, 1204, 1218, 1260, 1294, 1318, 1340, 1370, 1390, 1434, 1460, 1598, 1659, 1740, 1953, 2062, 2449, 2607, 2639, 2965, 3031, 3071, 3100, 3166, 3215, 3329, 3476, 3629, 3715, 3912, 3945, 3963, 3988, 4357, 4383, 4457, 4678, 4766, 4843, 4876, 5014, 5047, 5086, 5201, 5332, 5402, 5432, 5454, 5476, 5504, 5549, 5588, 5726, 5749, 5772, 5837, 5852, 5921, 5955, 5992, 6083, 6152], 'Scholar)': [491, 546, 1295, 1391, 1599, 2063, 2450, 4458, 5750, 5993], 'such': [492, 529, 778, 1048, 5705, 5889, 5906, 6051, 6185], 'genes': [495, 1512, 3881, 3992, 4285, 4643, 5148, 5410, 5487, 5791, 5863, 5905, 6206], 'generally': [497, 996, 1629], 'transcriptionally': [498, 639], 'silent.': [499], 'Two': [500], 'mechanisms': [501, 6003], 'have': [502, 623, 990, 1392, 1402, 1574, 1663, 1699, 1765, 3034, 3302, 3870, 4318, 4615, 4975, 5777], 'proposed': [504, 4617], 'explain': [506, 4619], 'repression:': [508], 'first': [510, 2126, 2826, 3239, 3333, 4788, 5624], 'causes': [514], 'interference': [515], 'binding': [518, 577, 3793], 'transcription': [520, 3968], 'factors': [521], 'shown': [525, 891, 1403, 1664, 3035, 3303, 3456, 4031, 4229, 4487, 4652, 5143, 5371, 5627, 5995], 'several': [527, 1071, 2095, 3776, 4611], 'proteins': [528, 581, 621, 2647], 'AP2': [531], '(2Comb': [532], 'M.': [533, 743, 1090, 1125, 1183, 1246, 1286, 1303, 1325, 1419, 1445, 1583, 1644, 1725, 1942, 2052, 2434, 2592, 2624, 2950, 3016, 3056, 3090, 3152, 3154, 3200, 3314, 3461, 3705, 4342, 4368, 4447, 4668, 4751, 4846, 5017, 5388, 5417, 5439, 5489, 5758, 5930, 5940], 'Goodman': [534], 'H.M.': [535], 'Nucleic': [536, 864, 1093, 3091, 3157, 3706], 'Acids': [537, 865, 1094, 3092, 3158, 3707], 'Res.': [538, 866, 1095, 3093, 3159, 3708, 3978, 3981, 5913], '1990;': [539, 1113, 3094], '18:': [540, 3095], '3975-3982Crossref': [541], '(352)': [544], 'c-Myc': [548], '(3Prendergast': [549], 'G.C.': [550], 'Ziff': [551], 'E.B.': [552], 'Science.': [553], '1991;': [554, 2632], '251:': [555], '186-189Crossref': [556], '(432)': [559], 'Scholar).': [561, 664, 874, 930, 955, 1219, 1341, 1660, 1741, 1954, 2640, 2966, 3032, 3072, 3101, 3167, 3330, 3477, 3630, 3716, 3989, 4384, 4877, 5202, 5333, 5505, 5773, 5853, 6084, 6153], 'The': [562, 956, 973, 1867, 2253, 2280, 2395, 2407, 2552, 2699, 2715, 2812, 2849, 2988, 3363, 3478, 3512, 3717, 3857, 4055, 4147, 4221, 4485, 4555, 5101, 5203, 6009], 'second': [563], 'involves': [565], 'recruitment': [567], 'various': [569], 'repressor': [570], 'complexes': [571, 619], 'via': [575], '(MBDs).': [582], '1The': [583], 'abbreviations': [584], 'are:': [586], 'MBD,': [587], 'protein;': [590, 614], 'MBD2/dMTase,': [591, 4388], 'MBD2/DNA': [592], 'demethylase;': [593], 'VPA,': [594, 847, 1052, 3558, 3580, 3664, 4078, 4471, 4624, 6187], 'valproate/valproic': [595], 'acid;': [596], 'VPM,': [597, 3596, 4104, 4912], 'valpromide;': [598], 'HDAC,': [599], 'deacetylase;': [601], 'Ac-H3,': [602], 'acetyl': [603], 'H3;': [605], 'TSA,': [606, 2943], 'trichostatin': [607, 780], 'A;': [608], '5-aza,': [609], '2′deoxycytidine-5-aza-CdR;': [610], 'GFP,': [611], 'green': [612], 'fluorescent': [613], 'ChIP,': [615], 'immunoprecipitation.': [617], 'These': [618, 4539, 5288], 'contain': [620], 'deacetylase': [625, 3451, 5227], 'remodeling': [628], 'activities,': [629], 'leading': [630, 5240], 'formation': [633], 'more': [636, 3835, 3843], 'compact': [637], 'inactive': [640], '(4Nan': [642], 'X.': [643, 6116], 'Ng': [644], 'H.H.': [645, 1345, 5524], 'Johnson': [646, 1350, 5529], 'C.A.': [647, 1351, 5530], 'Laherty': [648], 'C.D.': [649], 'Turner': [650, 1352, 5531], 'B.M.': [651, 1353, 5532], 'Eisenman': [652], 'R.N.': [653], 'Bird': [654, 1360, 1380, 5539, 5578], 'Nature.': [656, 1287], '393:': [658], '386-389Crossref': [659], '(2788)': [662], 'Valproic': [665], 'acid/Valproate/2-n-propylpentanoic': [666], '(VPA)': [668], 'also': [681, 794, 877, 966, 1471, 2730, 3290, 3680, 3994, 4100, 5561], 'effective': [682, 2902, 5314], 'stabilizer': [686], 'migraine': [689], 'therapy.': [690], 'suggest': [693, 960], 'drug,': [696, 6035], 'addition': [698, 3479, 3513], 'known': [702, 842, 1472], 'classical': [703, 1056], 'actions,': [704], 'modulate': [706], 'epigenome': [708], 'inhibiting': [710, 1062, 4697, 4730], 'deacetylases': [712], '(HDACs)': [713], '(5Phiel': [714, 3603, 3886, 3919, 4817, 4988], 'C.J.': [715, 3604, 3887, 3920, 4818, 4989], 'Zhang': [716, 1346, 3605, 3888, 3921, 4819, 4990, 5525, 5711, 5732], 'F.': [717, 758, 3606, 3889, 3922, 4820, 4861, 4991, 5032], 'Huang': [718, 3607, 3890, 3923, 3949, 4821, 4992], 'E.Y.': [719, 3608, 3891, 3924, 4822, 4993], 'Guenther': [720, 3609, 3892, 3925, 4823, 4994], 'M.G.': [721, 3610, 3893, 3926, 4824, 4995], 'Lazar': [722, 3611, 3894, 3927, 4825, 4996], 'M.A.': [723, 2040, 3612, 3895, 3928, 4435, 4826, 4997], 'Klein': [724, 1130, 3613, 3896, 3929, 4827, 4998], 'P.S.': [725, 3614, 3897, 3930, 4828, 4999], 'Biol.': [727, 1168, 1191, 1305, 1327, 1421, 1447, 1585, 1646, 1727, 1944, 2436, 2594, 2630, 2952, 3018, 3058, 3202, 3316, 3463, 3616, 3899, 3932, 4344, 4370, 4753, 4830, 5001, 5419, 5441, 5463], 'Chem.': [728, 1192, 1306, 1328, 1422, 1448, 1586, 1647, 1728, 1945, 2437, 2595, 2631, 2953, 3019, 3059, 3203, 3317, 3464, 3617, 3900, 3933, 4345, 4371, 4754, 4831, 5002, 5420, 5442, 5464], '2001;': [729, 767, 1193, 1307, 1384, 1423, 1587, 1648, 2596, 2954, 3020, 3060, 3204, 3318, 3465, 3618, 3901, 3934, 4346, 4755, 4832, 4870, 5003, 5041, 5421, 5498, 5582, 5766, 5949], '276:': [730, 1194, 1308, 1424, 1588, 1649, 2597, 2955, 3021, 3061, 3205, 3319, 3466, 3619, 3902, 3935, 4347, 4756, 4833, 5004, 5422], '36734-36741Abstract': [731, 3620, 3903, 3936, 4834, 5005], 'Full': [732, 734, 1116, 1172, 1174, 1196, 1198, 1310, 1312, 1332, 1334, 1426, 1428, 1452, 1454, 1590, 1592, 1651, 1653, 1732, 1734, 1949, 2441, 2443, 2599, 2601, 2635, 2957, 2959, 3023, 3025, 3063, 3065, 3207, 3209, 3321, 3323, 3468, 3470, 3621, 3623, 3904, 3906, 3937, 3939, 4349, 4351, 4375, 4377, 4758, 4760, 4835, 4837, 5006, 5008, 5424, 5426, 5446, 5448, 5468, 5470], 'Text': [733, 735, 1117, 1173, 1175, 1197, 1199, 1311, 1313, 1333, 1335, 1427, 1429, 1453, 1455, 1591, 1593, 1652, 1654, 1733, 1735, 1950, 2442, 2444, 2600, 2602, 2636, 2958, 2960, 3024, 3026, 3064, 3066, 3208, 3210, 3322, 3324, 3469, 3471, 3622, 3624, 3905, 3907, 3938, 3940, 4350, 4352, 4376, 4378, 4759, 4761, 4836, 4838, 5007, 5009, 5425, 5427, 5447, 5449, 5469, 5471], 'PDF': [736, 1118, 1176, 1200, 1314, 1336, 1430, 1456, 1594, 1655, 1736, 1951, 2445, 2603, 2637, 2961, 3027, 3067, 3211, 3325, 3472, 3625, 3908, 3941, 4353, 4379, 4762, 4839, 5010, 5428, 5450, 5472], '(1475)': [739, 3628, 3911, 3944, 4842, 5013], 'Scholar,': [741, 1103, 1123, 1148, 1181, 1205, 1319, 1371, 1435, 3946, 4358, 4844, 5015, 5433, 5455, 5727, 5838], '6Gottlicher': [742, 4845, 5016], 'Minucci': [744, 4847, 5018], 'S.': [745, 753, 921, 1139, 1152, 1189, 1240, 1252, 1282, 1441, 1721, 2042, 2044, 2430, 4364, 4437, 4439, 4848, 4856, 5019, 5027, 5193, 5382, 5394, 5764, 5829, 5984, 6122, 6144], 'Zhu': [746, 4849, 5020], 'P.': [747, 907, 1357, 2038, 4433, 4850, 5021, 5179, 5536, 5815, 5970], 'Kramer': [748, 4851, 5022], 'O.H.': [749, 4852, 5023], 'Schimpf': [750, 4853, 5024], 'Giavara': [752, 4855, 5026], 'Sleeman': [754, 4857, 5028], 'J.P.': [755, 1092, 4858, 5029], 'Lo': [756, 4859, 5030], 'Coco': [757, 4860, 5031], 'Nervi': [759, 4862, 5033], 'C.': [760, 3088, 4863, 5034], 'Pelicci': [761, 4864, 5035], 'P.G.': [762, 4865, 5036], 'Heinzel': [763, 4866, 5037], 'T.': [764, 944, 4867, 5038, 5322, 5495, 5842, 5926, 5932, 5936], '20:': [768, 4871, 5042], '6969-6978Crossref': [769, 4872, 5043], '(1568)': [772, 4875, 5046], 'Scholar),': [774, 1261, 1461, 3216, 3913, 3964, 4679, 4767, 5048, 5087, 5403, 5477, 5550, 5922, 5956], 'similar': [775, 3523, 4213, 4680, 5134], 'agents': [777], '(TSA)': [782], 'n-butyrate,': [784], 'triggering': [786], 'increase': [788, 893, 3496, 5095], 'expression.': [791, 832, 4103, 5272], 'Other': [792, 1342], 'studies': [793, 3869, 4637, 4809, 4974, 5776, 5856], 'genes.': [805, 4304, 5600], 'It': [806, 1522, 3778, 4649, 5214], 'was': [807, 1226, 1270, 1793, 1823, 1859, 1870, 1881, 2071, 2087, 2105, 2112, 2125, 2420, 2489, 2508, 2550, 2648, 2667, 2701, 2722, 2803, 3007, 3257, 3272, 3332, 3397, 4001, 4689], 'demonstrated': [808, 3184, 3871, 4573, 4976, 5778], 'reelin': [811, 851, 883, 5150, 5958], 'gene,': [812], 'which': [813, 1804, 2269, 2977, 3440, 3491, 3597, 3689, 4105, 4299, 4768, 4803, 4913, 5613, 6016], 'encodes': [814], 'neuronal': [816, 826], 'down-regulated': [820], 'schizophrenia,': [822], 'precursor': [827], 'cells,': [828, 3226, 3427, 4774, 5309], 'accompanied': [829], 'minimal': [831, 2859, 3418, 4065], 'Following': [833, 2215, 4073, 4466], 'these': [836, 1606, 3720, 3783, 4931, 5862], 'cells': [837, 1299, 1537, 1899, 1959, 2004, 2117, 2469, 2620, 2873, 3045, 3104, 3122, 3174, 3262, 3738, 4050, 4070, 4414, 4472, 5111, 5316, 5668, 5799], '5′-aza-2′-deoxycytidine': [839], '(5-aza-CdR),': [840], 'inhibitor,': [845, 1477, 4918], 'induced': [853, 1409, 3995, 4400, 4508, 5342], '(7Chen': [854], 'Y.': [855, 1347, 5526, 5754, 5756, 5938, 5946], 'Sharma': [856, 908, 5180, 5816, 5971], 'R.P.': [857], 'Costa': [858, 860, 912, 5184, 5820, 5975], 'R.H.': [859, 1209], 'E.': [861, 913, 3156, 4664, 5185, 5821, 5976, 6108, 6118], 'Grayson': [862, 910, 5182, 5818, 5973], 'D.R.': [863, 911, 5183, 5819, 5974], '2002;': [867, 923, 948, 1329, 1449, 1729, 2056, 2438, 4372, 4451, 5080, 5195, 5326, 5443, 5720, 5743, 5831, 5846, 5915, 5986, 6077], '30:': [868], '2930-2939Crossref': [869], '(234)': [872], 'revert': [878], 'down-regulation': [880], 'both': [882, 932, 1276, 3085, 4131, 4290, 5145, 5265, 5783], 'gad67': [885, 5152], 'caused': [886, 1543], 'l-methionine,': [888], 'agent': [890, 5626], '(8Tremolizzo': [896, 5168, 5804, 5959], 'L.': [897, 1127, 5169, 5805, 5960], 'Carboni': [898, 5170, 5806, 5961], 'G.': [899, 1131, 1940, 2628, 3948, 4672, 5171, 5712, 5733, 5807, 5962], 'Ruzicka': [900, 5172, 5808, 5963], 'W.B.': [901, 5173, 5809, 5964], 'Mitchell': [902, 5174, 5810, 5965], 'C.P.': [903, 5175, 5811, 5966], 'Sugaya': [904, 5176, 5812, 5967], 'I.': [905, 1107, 5177, 5813, 5968], 'Tueting': [906, 5178, 5814, 5969], 'R.': [909, 1160, 1187, 5181, 5817, 5972], 'Guidotti': [914, 5186, 5822, 5977], 'Proc.': [916, 1134, 1247, 5188, 5389, 5824, 5979, 6139], 'Natl.': [917, 1135, 1248, 5189, 5390, 5825, 5980, 6140], 'Acad.': [918, 1136, 1249, 5190, 5391, 5826, 5981, 6141], 'Sci.': [919, 1137, 1250, 5191, 5392, 5827, 5982, 6142], 'U.': [920, 1138, 1251, 5192, 5393, 5828, 5983, 6143], '99:': [924, 5196, 5832, 5987], '17095-17100Crossref': [925, 5197, 5833, 5988], '(346)': [928, 5200, 5836, 5991], 'Similarly,': [931], '5-aza-CdR': [933, 2104, 5311], '5-lipoxygenase': [940, 5300], '(9Manev': [941, 5319], 'H.': [942, 1111, 1355, 5320, 5491, 5534, 5760, 5762, 5840, 5928, 5944], 'Uz': [943, 5321, 5841], 'Eur.': [945, 5323, 5843], 'Pharmacol.': [947, 5325, 5845], '445:': [949, 5327, 5847], '149-150Crossref': [950, 5328, 5848], '(26)': [953, 5331, 5851], 'presented': [958, 2851, 3722, 4244], 'above': [959, 3658], 'may': [965, 5232], 'be': [967, 1038, 1408, 1474, 1504, 3407, 4154, 4566, 4634, 5303, 5615, 5629, 5879, 5997, 6019, 6201], 'able': [968, 5406, 5630, 6090], 'trigger': [970, 5233], 'prospect': [974], 'erasing': [976], 'established': [977, 6165], 'somatic': [982, 1779], 'tissue': [984, 2121], 'extremely': [986], 'attractive': [987], 'might': [989, 1482, 1503, 4153, 4725, 5878, 6005, 6200], 'important': [991, 1766, 5649, 5896], 'therapeutic': [992, 1771, 4621, 5625, 5897], 'applications.': [993], 'However,': [994, 1068, 3807, 5334, 5694, 6154], 'accepted': [997], 'model': [998, 1578, 6103], 'pattern': [1004, 3693, 3733, 4944], 'irreversible': [1007], 'reaction,': [1008], 'maintained': [1009], 'only': [1010, 1023, 1059, 3078, 3357, 4390, 5113, 5313, 6010, 6065], 'methyltransferase': [1013, 1800, 3566, 6026, 6041], 'activities.': [1014], 'If': [1015, 1496, 4196, 6173], 'case,': [1019, 3812], 'then': [1020, 1854, 2157, 2240, 2365, 2702, 4208, 6198], 'could': [1022, 1058, 4565, 4632], 'come': [1024], 'about': [1025, 4327], 'when': [1026, 3079, 3146, 3358], 'occurs': [1028], 'methyltransferase.': [1034], 'Therefore,': [1035], 'should': [1037, 2999], 'impossible': [1039, 1524], 'postmitotic': [1046, 5682, 5703, 5887], 'tissues': [1047, 1514, 5683, 5704, 5797, 5888], 'brain.': [1051, 5892, 6046], 'according': [1053], 'model,': [1057], 'act': [1060, 1483, 3563, 5373], 'there': [1069, 3415], 'pieces': [1072], 'evidence': [1074], 'indicating': [1075, 3217, 4123], 'occur': [1080, 3834], 'cell': [1085, 1236, 1624, 6028], 'division': [1086], '(10Wilks': [1087], 'Seldran': [1089], 'Jost': [1091], '1984;': [1096], '12:': [1097], '1163-1177Crossref': [1098], '(68)': [1101, 5954], '11Paroush': [1104], 'Z.': [1105], 'Keshet': [1106], 'Yisraeli': [1108], 'Cedar': [1110], 'Cell.': [1112], '63:': [1114], '1229-1237Abstract': [1115], '(129)': [1121], '12Szyf': [1124], 'Eliasson': [1126], 'Mann': [1128], 'V.': [1129, 2036, 2626, 3970, 4431], 'Razin': [1132], '1985;': [1141], '82:': [1142], '8090-8094Crossref': [1143], '(86)': [1146], '13Oswald': [1149], 'Engemann': [1151], 'Lane': [1153], 'N.': [1154, 1244, 1284, 1301, 1321, 1417, 1437, 1439, 1581, 1642, 1717, 1719, 2426, 2428, 2590, 2948, 3014, 3054, 3198, 3312, 3459, 4340, 4360, 4362, 4666, 4749, 5386, 5415, 5435], 'Mayer': [1155], 'W.': [1156, 1162, 1164, 5077, 5714, 5737], 'Olek': [1157], 'Fundele': [1159], 'Dean': [1161], 'Reik': [1163], 'Walter': [1165], 'Curr.': [1167], '2000;': [1169], '10:': [1170], '475-478Abstract': [1171], '(802)': [1179], '14Lucarelli': [1182], 'Fuso': [1184], 'Strom': [1186], 'Scarpa': [1188], '7500-7506Abstract': [1195], '(113)': [1203], '15Bruniquel': [1206], 'D.': [1207, 1359, 1443, 1723, 2050, 2432, 4366, 4445, 5538], 'Schwartz': [1208], 'Nat.': [1210, 1362, 5541, 6073], 'Immunol.': [1211], '2003;': [1212, 5465, 6146], '4:': [1213, 2057, 4452], '235-240Crossref': [1214], '(404)': [1217], 'addition,': [1221], 'purified': [1227], 'laboratory': [1230, 4747], 'lung': [1234], 'cancer': [1235], 'line': [1237, 1625], 'A549': [1238], '(16Ramchandani': [1239, 5381], 'Bhattacharya': [1241, 2043, 4438, 5383], 'S.K.': [1242, 1280, 5384], 'Cervoni': [1243, 1283, 5385], 'Szyf': [1245, 1285, 1302, 1324, 1418, 1444, 1582, 1643, 1724, 1941, 2051, 2433, 2591, 2949, 3015, 3055, 3199, 3313, 3460, 4341, 4367, 4446, 4750, 5387, 5416, 5438], '1999;': [1254, 1288, 1364, 3957, 4674, 5396, 5543], '96:': [1255, 5397], '6107-6112Crossref': [1256, 5398], '(271)': [1259, 5401], 'found': [1271], 'actively': [1273, 5672], 'demethylate': [1274], 'vitro': [1278, 1612, 1796, 5380, 5520], '(17Bhattacharya': [1279], 'Ramchandani': [1281, 2041, 4436], '397:': [1289], '579-583Crossref': [1290], '(546)': [1293], 'living': [1298, 1536, 1761, 4773], '(18Cervoni': [1300, 1416, 1580, 1641, 2947, 3013, 3053, 3197, 3311, 3458, 4339, 4748, 5414], '40778-40787Abstract': [1309, 1425, 1589, 1650, 2598, 2956, 3022, 3062, 3206, 3320, 3467, 4348, 4757, 5423], '(253)': [1317, 1433, 1597, 1658, 2606, 2964, 3030, 3070, 3214, 3328, 3475, 4356, 4765, 5431], '19Detich': [1320, 5434], 'Theberge': [1322, 5436], '277:': [1330, 1450, 1730, 2439, 4373, 5444], '35791-35794Abstract': [1331, 5445], '(145)': [1339, 5453], '(20Ng': [1344, 5523], 'Hendrich': [1348, 5527], 'B.': [1349, 1373, 1377, 2046, 2048, 4441, 4443, 5528, 5571, 5575, 5731, 6112], 'Erdjument-Bromage': [1354, 5533], 'Tempst': [1356, 5535], 'Reinberg': [1358, 5537], 'Genet.': [1363, 5542], '23:': [1365, 5544], '58-61Crossref': [1366, 5545], '(0)': [1369, 5548], '21Hendrich': [1372], 'Guy': [1374, 5572], 'Ramsahoye': [1376, 5574], 'Wilson': [1378, 5576], 'V.A.': [1379, 5577], 'Genes.': [1382, 5580], 'Dev.': [1383, 5581], '15:': [1385, 5583], '710-723Crossref': [1386, 5584], '(394)': [1389, 5587], 'nevertheless': [1393], 'disputed': [1394], 'MBD2.': [1399, 2784], 'Since': [1400, 1661, 3828], 'inhibited': [1411], 'modifying': [1413], '22Cervoni': [1436, 4359], 'Detich': [1438, 1718, 2427, 4361], 'Seo': [1440, 1720, 2429, 4363], 'Chakravarti': [1442, 1722, 2431, 4365], '25026-25031Abstract': [1451, 1731, 2440, 4374], '(157)': [1459, 1739, 2448, 4382], 'view': [1464], 'fact': [1467], 'HDAC': [1476, 2945, 3576, 3601, 4144, 4169, 4812, 4917, 6049, 6183], 'hypothesize': [1479], 'increasing': [1485, 1489, 3244, 4965], 'accessibility': [1491, 4967, 5643], 'acts': [1498, 5222], 'mechanism,': [1501], 'stably': [1507], 'specific': [1511, 3796, 5599, 5610], 'where': [1515], 'take': [1520, 6178], 'place.': [1521], 'determine': [1526, 2012, 2537, 3569, 5339, 5860], 'whether': [1527, 3570, 4004, 4011, 4387, 4692, 4777, 5217, 5230, 5340, 5681, 5861], 'hypomethylation': [1528, 4658], 'vivo': [1533], 'following': [1538, 2286, 2296, 2496, 2553, 2889, 4188], 'either': [1544, 2025, 2140, 3547, 4569, 4728], 'passive': [1546, 1696], 'resulting': [1548, 2312], 'inhibition': [1550, 1707], 'synthesis': [1556], '(as': [1557, 4572], 'with': [1558, 1797, 1825, 1920, 1962, 2081, 2128, 2136, 2167, 2335, 2704, 2732, 2744, 2816, 2845, 2869, 2883, 2893, 3190, 3264, 3284, 3292, 3335, 3343, 3591, 3767, 4027, 4075, 4239, 4275, 4417, 4421, 4468, 4798, 4807, 4962, 5074, 5103, 5128, 5158, 5292, 5483, 5617, 5870], '5-aza-CdR),': [1559], 'removal': [1565], 'group': [1569], 'enzyme.': [1572, 3856, 5647], 'recently': [1575, 1700], 'described': [1576, 1935, 2424, 2463, 2622, 2782], 'system': [1579, 2975], 'allows': [1601, 3441], 'one': [1602, 1963, 3813, 4209], 'distinguish': [1604], 'two': [1607], 'mechanisms.': [1608, 4703], 'When': [1609], 'transiently': [1617, 1918, 2834, 2909, 2937, 4038, 4890], 'transfected': [1618, 1919, 2835, 2863, 2879, 2910, 2938, 3263, 3438, 3534, 4039, 4416, 4891], 'into': [1619, 6021], 'HEK': [1626, 1897, 2101, 2115, 2467, 2618, 3003, 3043, 3121, 3224, 3260, 3425, 3736, 4048, 4412, 5666], '293,': [1627], 'remains': [1630, 2284], 'methylated.': [1631], 'Increasing': [1632], 'replicate': [1670, 3001, 3041, 3222], 'time': [1673], 'frame': [1674], 'experiment,': [1677], 'nor': [1678], 'methyltransferases,': [1684], 'measured': [1687, 2327], 'inhibitors': [1712, 3452, 6050], '(22Cervoni': [1716, 2425], 'utilize': [1746], 'test': [1750, 4776], 'hypothesis': [1752, 2929, 3662, 4277, 4708, 5356], 'Our': [1763, 3182, 4636], 'potential': [1767], 'implications': [1768, 5900], 'reversal': [1772], 'pathological': [1774], 'tissues.': [1780, 6217], 'Vitro': [1782], 'Methylation': [1783], 'Substrates—CMV-GFP': [1785], '(pEGFP-C1': [1786], 'Clontech;': [1788], 'GenBank™': [1789], 'accession': [1790], 'number': [1791, 1901, 2505, 2518, 2773, 5903], 'U55763)': [1792], 'SssI': [1798, 1829, 1847], 'CpG': [1799, 3760, 3773, 3801, 3822], '(New': [1801], 'England': [1802], 'Biolabs),': [1803], 'methylates': [1805, 3111], 'all': [1806, 2725, 3757], 'cytosine': [1807], 'residues': [1808], 'within': [1809, 3377], 'double-stranded': [1811], 'dinucleotide': [1812], 'recognition': [1813], 'sequence': [1814, 3076, 3139, 3348, 3355], '5′..': [1815], '.CG..': [1816], '.3′.': [1817], 'Ten': [1818], 'μg': [1819, 2023, 2485, 2644], 'incubated': [1824, 1861], '12': [1826], 'units': [1827, 1845, 2130, 2138], 'recommended': [1832, 2521], 'buffer': [1833, 2196], 'containing': [1834, 1992, 2197, 2250], '800': [1835], 'μm': [1836, 1974, 3294, 3526], 'S-adenosylmethionine': [1837, 1852], '3': [1839, 1865, 4978], 'h': [1840, 1956, 2008, 2193, 3281], 'at': [1841, 1906, 2188, 2476, 2571, 2669, 2696, 2711, 3694, 4545, 5055, 5098, 5218, 5800], '37': [1842], '°C.': [1843, 2577, 2698], 'Twelve': [1844], '0.16': [1849], 'μmol': [1850], 'were': [1853, 1904, 1960, 1996, 2005, 2093, 2147, 2165, 2186, 2219, 2263, 2413, 2459, 2470, 2493, 2527, 2555, 2583, 2615, 2729, 2761, 2792, 3289, 3375, 3810, 4198, 4415, 4473, 4525, 5994], 'added,': [1855], 'further': [1860, 5207, 5855], 'additional': [1864, 2000], 'h.': [1866], 'recovered': [1871], 'phenol/chloroform': [1873], 'extraction': [1874], 'ethanol': [1876], 'precipitation,': [1877], 'complete': [1879, 3521, 3754], 'confirmed': [1882, 3273, 3681, 4521], 'observing': [1884], 'full': [1885, 3269], 'protection': [1886], 'HpaII': [1888, 2141, 2266, 2287, 2342, 2374, 2393, 3351, 3504], 'digestion.': [1889, 3129, 3181], 'Cell': [1890], 'Culture': [1891], 'Transient': [1893], 'Transfections—Human': [1894], '(ATCC': [1900], 'CRL': [1902], '1573)': [1903], 'plated': [1905], 'density': [1908, 2478], '7.5': [1910], '×': [1911, 2405, 2481, 3403], '104/well': [1912], '6-well': [1915], 'dish': [1916], '80': [1921], 'ng': [1922], '(methylated': [1925], 'mock-methylated)': [1927], 'using': [1928, 2097, 2118, 2176, 2265, 2510, 2530, 2763, 2794, 2842, 3046, 4022, 4517], 'calcium': [1930], 'phosphate': [1931], 'precipitation': [1932], 'method': [1933], 'previously': [1936, 2464, 3457, 4319, 4744, 5511], '(23Rouleau': [1937], 'Tanigawa': [1939, 2627], '1992;': [1946], '267:': [1947], '7368-7377Abstract': [1948], 'Twenty-four': [1955], 'after': [1957, 1998, 2009, 4560], 'transfection,': [1958], 'treated': [1961, 3283, 3291, 5073, 5157], 'following:': [1966], '1–20': [1967, 4076], 'mm': [1968, 1979, 2083, 2205, 2236, 2895, 3286, 3516, 3557, 3640, 3748, 4077, 4193, 4470, 4979, 5212], '(sodium': [1970], 'salt,': [1971], 'Sigma),': [1972], '0.3': [1973, 3293, 3525], 'TSA': [1975, 3295], '(Sigma),': [1976], '5': [1978, 2480, 3639, 5056], 'valpromide': [1980], '(VPM)(kindly': [1981], 'donated': [1982], 'Katwijk': [1984], 'chemie': [1985], 'bv),': [1986], 'left': [1988], 'untreated.': [1989], 'Fresh': [1990], 'media': [1991], 'VPM': [1995, 3651], 'replaced': [1997], '24': [2001], 'h,': [2002], 'harvested': [2006, 4474], '72': [2007, 3280], 'transfection.': [2010], 'To': [2011, 2967, 3568, 4174], 'CMV-GFP,': [2021, 2940, 3490, 3533, 4419], '1.6': [2022], 'pRetroTet': [2027, 2066], 'On': [2028, 2067], 'MBD2': [2029, 2610, 4423, 5522], '(24Slack': [2033, 4428], 'Bovenzi': [2035, 4430], 'Bigey': [2037, 4432], 'Ivanov': [2039, 4434], 'tenOever': [2045, 4440], 'Lamrihi': [2047, 4442], 'Scherman': [2049, 4444], 'Gene': [2054, 4449], 'Med.': [2055, 4450], '381-389Crossref': [2058, 4453], '(47)': [2061, 4456], 'empty': [2068, 4461], 'vector': [2069, 4462], '(Clontech)': [2070], 'transfection': [2076, 3276, 5412], 'mixture': [2077], 'followed': [2078, 2133, 2775, 3340], '20': [2082, 2137, 2691, 2894, 3515, 3556, 3747, 4469, 5211], 'VPA.': [2084, 3287, 4173, 4554, 5213, 5367], 'Each': [2085], 'experiment': [2086, 4249], 'performed': [2088, 2094, 2421, 2460, 2494, 2584, 2762], 'triplicate,': [2090], 'experiments': [2092, 2412, 5413], 'times': [2096, 2242], 'different': [2098, 3772, 3840], 'cultures': [2099], 'purchased': [2106], '(Sigma).': [2108], 'Southern': [2109, 4478], 'Blot': [2110, 2579], 'Analysis—DNA': [2111], 'extracted': [2113], 'DNeasy': [2120], 'kit': [2122, 2181, 2502, 2719], '(Qiagen).': [2123], 'digested': [2127, 3189], '50': [2129, 2643], 'EcoRI': [2132, 2297, 3337], 'digestion': [2135, 2288, 2298, 3196, 3342], 'MspI': [2143, 3344], 'restriction': [2144, 2267, 3048, 3338], 'enzymes.': [2145], 'Samples': [2146], 'subjected': [2148, 4476], 'electrophoresis': [2150], '1.5%': [2153], 'agarose': [2154], 'gel': [2155], 'transferred': [2158, 2655], 'Hybond-N+': [2160], 'membrane': [2161], '(Amersham': [2162, 2720], 'Biosciences).': [2163], 'Blots': [2164], 'probed': [2166, 2743], '32P-labeled': [2169], 'cDNA': [2171], 'probe': [2172, 2338], '(AvaII-Cfr10I': [2173], 'fragment)': [2174], 'synthesized': [2175], 'random': [2178], 'priming': [2179], 'labeling': [2180], '(Roche': [2182], 'Applied': [2183], 'Science).': [2184], 'Membranes': [2185, 2728], 'hybridized': [2187], '68': [2189], '°C': [2190], '4–6': [2192], '0.5': [2198, 2484], 'm': [2199, 2230, 2681, 2684], 'sodium': [2200, 2231], 'phosphate,': [2201, 2232], 'pH': [2202, 2233, 2686], '6.8,': [2203, 2234], '1': [2204, 2235, 5099], 'EDTA,': [2206], '7%': [2207], 'SDS,': [2208, 2228], '0.2': [2210, 2683], 'mg/ml': [2211], 'herring': [2212], 'sperm': [2213], 'hybridization,': [2216], 'membranes': [2218, 2791], 'washed': [2220], 'twice': [2221], '10': [2223, 2244, 4192], 'min': [2224, 2245], '5%': [2227, 2693], '0.04': [2229], 'EDTA': [2237], 'solution': [2238, 2249, 2676], 'four': [2241], 'same': [2248, 2341, 2392, 3648, 3821, 5686], '1%': [2251], 'SDS.': [2252], 'fraction': [2258, 2860, 2877], 'molecules': [2261, 2360], 'demethylated': [2264], 'enzyme,': [2268], 'cleaves': [2270, 3074, 3346, 3353], 'unmethylated': [2271, 2305, 2346, 2371, 3532, 3880, 4186, 4219, 4224, 4266], 'CCGG': [2272, 2278, 3356], 'but': [2273, 3999, 4687], 'cleave': [2276, 3137], 'sequences.': [2279], 'GFP': [2282, 2306, 2337, 2488, 2564, 2865, 4059, 4115], 'intact': [2285], 'identical': [2291, 3536, 4189], 'fragment': [2294, 2316, 3367, 3505], 'obtained': [2295], '(see': [2299, 2317], 'Fig.': [2300, 2318, 2853, 3410, 3528, 3631, 3724, 4033, 4231, 4246, 4483, 4489, 4498], '2C,': [2301, 2319], 'Me),': [2302], 'whereas': [2303, 2857, 5310], 'cleaved': [2309], 'HpaII,': [2311], '0.5-kb': [2315], 'U).': [2320], 'scanned': [2322], 'each': [2323, 2756, 2810, 3378, 3395], 'HpaII-digested': [2324, 3365], 'lane': [2325, 2343, 2375, 3396], 'intensity': [2329, 2368], 'total': [2332, 2383, 2807, 3391], 'signal': [2333, 2372, 2384, 2802], 'hybridizing': [2334], '(including': [2344], 'U': [2347], 'Me': [2350], 'fragments);': [2351], 'value': [2353, 2379, 5060], 'equal': [2355, 2751], '100%': [2357, 3309], 'lane.': [2363, 2394, 2757, 2811], 'determined': [2366, 3240, 3398, 4003, 4010, 4386], 'per': [2373], 'divided': [2377], '(U)': [2380, 3506], '(U': [2387], '+': [2388, 2403, 2688, 2692, 3401], 'M)': [2389], 'percent': [2396, 3388], 'calculated': [2400], '(U/(U': [2402], 'Me))': [2404, 3402], '100.': [2406, 3404], 'results': [2408, 2850, 3482, 3518, 3642, 3683, 3718, 3751, 4486], 'three': [2410, 3771, 4495], 'quantified': [2414, 2793, 3376, 4492], 'averaged.': [2416], 'Bisulfite': [2417, 4927], 'Mapping—Bisulfite': [2418], 'mapping': [2419, 4928], 'exactly': [2422, 2585], 'Chromatin': [2451, 2507], 'Immunoprecipitation': [2452], '(ChIP)': [2453], 'Assays—CMV-GFP': [2454], 'transfections': [2455, 4190], 'treatments': [2458], 'essentially': [2461], 'except': [2465], 'seeded': [2471], '10-cm': [2473], 'plates': [2474], '(2/sample)': [2475], '105/plate,': [2482], 'used.': [2490, 2551], 'ChIP': [2491, 2500, 2843, 4785], 'assays': [2492, 2844], 'Upstate': [2498], 'Biotechnology': [2499], 'protocol': [2503], '(catalog': [2504], '17-295).': [2506], 'immunoprecipitated': [2509], 'anti-acetylated': [2511], 'H3': [2513, 2847, 4795, 4959], 'antibody': [2514, 2661, 2708, 2746, 2770, 2779, 4520], '(Upstate': [2515], 'Biotechnology,': [2516], 'catalog': [2517, 2772], '06-599)': [2519], 'manufacturer.': [2524], 'PCR': [2525], 'reactions': [2526], 'repeated': [2528], 'exhaustively': [2529], 'serial': [2531], 'dilutions': [2532], '(1–1:10,000)': [2533], 'template': [2535], 'linear': [2539], 'range': [2540], 'PCR,': [2543], 'final': [2546], 'dilution': [2547, 2671, 2766], '1100': [2549], 'primers': [2554], 'amplify': [2558], '500-bp': [2560], 'region': [2561], 'gene:': [2565], '5′-CAAGGGCGAGGAGCTGTT-3′': [2566], '(sense)': [2567], '5′-CGGCCATGATATAGACGTTG-3′': [2569], '(antisense)': [2570], 'annealing': [2573], 'temperature': [2574], '58': [2576], 'Western': [2578, 2581, 2611, 2726, 2759, 2787, 4024, 4514, 4576], 'Analysis—GFP': [2580], 'blots': [2582, 2760, 2788], 'Ref.': [2588], '18Cervoni': [2589], 'Scholar.': [2608], 'For': [2609], 'blots,': [2612], 'nuclear': [2613, 2646], 'extracts': [2614], 'prepared': [2616], '(25Szyf': [2623], 'Bozovic': [2625], '266:': [2633], '10027-10030Abstract': [2634], 'Twenty-five': [2641], 'loaded': [2649], 'onto': [2650], '10%': [2652, 2739], 'SDS-PAGE': [2653], 'nitrocellulose': [2657], 'membrane.': [2658], 'Anti-MBD2': [2659], 'monoclonal': [2660, 2769], '(IMG147,': [2662], 'Imgenex,': [2663], 'San': [2664], 'Diego,': [2665], 'CA)': [2666], '1:200': [2673], 'Tris-buffered': [2678], 'saline': [2679], '(0.05': [2680], 'Tris,': [2682], 'NaCl,': [2685], '7.6)': [2687], '0.5%': [2689], 'Tween': [2690], 'milk': [2694], 'overnight': [2695], '4': [2697], 'blot': [2700, 4025, 4479, 4515, 4577], 'reacted': [2703], 'peroxidase-conjugated': [2705], 'anti-mouse': [2706], 'secondary': [2707, 2778], '(Jackson': [2709], 'ImmunoResearch)': [2710], '1:20,000': [2713], 'dilution.': [2714], 'enhanced': [2716, 5242], 'chemiluminescence': [2717], 'detection': [2718], 'Biosciences)': [2721], 'blots.': [2727], 'stained': [2731], '0.1%': [2733], 'Amido': [2734], 'Black': [2735], '(in': [2736], '25%': [2737], 'isopropanol,': [2738], 'acetic': [2740], 'acid)': [2741], 'β-actin': [2748, 2758], 'confirm': [2750], 'loading': [2752, 3384], '1:5000': [2765], 'anti-β-actin': [2768], '(Sigma': [2771], 'A-5316)': [2774], 'mouse': [2777, 6102], 'just': [2781], 'Both': [2785], 'Amido-stained': [2790], 'NIH': [2795], 'Image': [2796], '1.62': [2797], 'software,': [2798], 'GFP/MBD2': [2801], 'normalized': [2804], 'Association': [2813], 'Acetylated': [2817], 'Histones': [2818], 'Is': [2819, 3862, 3867, 4306], 'Increased': [2820], 'Presence': [2823], 'VPA—We': [2825, 4317], 'validated': [2827, 3008], 'system,': [2841, 3546], 'anti-acetyl-histone': [2846], '(anti-Ac-H3).': [2848], '1A': [2854], 'that,': [2856, 3637], 'associated': [2868, 2882, 4797, 4961, 5482], 'Ac-H3': [2870, 2884], 'control': [2872, 3299, 3381], '(lane': [2874, 2887, 4051], '3),': [2875], 'increased': [2885, 4096], '7-fold': [2886], '6)': [2888], '48-h': [2891], '(Fig.': [2897, 3254, 3277, 4071, 4118, 4134, 4534, 4801, 4894, 4922, 4947, 5255, 5286], '1B).': [2898], 'inducing': [2904, 3883, 4956], 'around': [2907], 'gene.': [2913], 'Stimulates': [2915], 'Active': [2916, 4313], 'Demethylation': [2917, 4314], 'Ectopically': [2919], 'Methylated': [2920, 3860], 'Dose-dependent': [2924], 'Manner—We': [2925], 'next': [2926], 'tested': [2927, 3762, 4706], 'similarly': [2941], 'inhibitor': [2946, 3602, 4685, 5228], 'measure': [2968], 'must': [2972], 'use': [2973, 5670, 6067], 'interest': [2981], '(i.e.': [2982], 'CMV-GFP)': [2983, 3145], 'undergo': [2986], 'replication.': [2987], 'bear': [2993, 3107], 'origin': [2995], 'cells;': [3005], 'previous': [3011, 4808, 5294, 5775], 'study': [3012, 5105, 5336, 5592], 'enzymes': [3049, 4335], 'DpnI': [3050, 3073, 3128, 3191], 'XbaI': [3052, 3180, 3195], 'GATC': [3077], 'adenine': [3081, 3113, 3148], 'strands': [3086], '(26McWhinney': [3087], 'Leffak': [3089], '1233-1242Crossref': [3096], '(98)': [3099], 'Because': [3102], 'mammalian': [3103, 3173], 'do': [3105, 4726, 5089, 5676, 5696], 'methylase': [3109], 'GATC,': [3115], 'will': [3123, 3175], 'render': [3124, 3176], 'resistant': [3126, 3193], 'XbaI,': [3130], 'hand,': [3134], 'TCTAGATC': [3140], '(which': [3141, 3345, 3352], 'present': [3143], '(27McClelland': [3151], 'Nelson': [3153], 'Raschke': [3155], '1994;': [3160, 3709], '22:': [3161, 3710], '3640-3659Crossref': [3162], '(354)': [3165], 'Replication': [3168], 'sensitive': [3178], 'completely': [3188], 'therefore,': [3228, 4717], 'any': [3229], 'observed': [3231, 4061], 'occurring': [3233, 4067], 'actively.': [3234], 'study,': [3237], 'doses': [3245, 4089, 5160], '2).': [3255], 'isolated': [3258], '(whose': [3268], 'status': [3271], 'prior': [3274], '2A))': [3278], '0–20': [3285], 'Cells': [3288], 'positive': [3298], 'leads': [3306], 'nearly': [3308], 'linearized': [3334], 'enzyme': [3339, 5378], 'CCGG)': [3349], 'methylated).': [3362], 'demethylated,': [3364, 5865], '529-bp': [3366], '(U),': [3368], 'undigested': [3372, 3509], '(Me)': [3374], 'sample': [3379], '(to': [3380], 'possible': [3383, 5123, 5604, 6176], 'differences),': [3385], '(Me/(U': [3400], 'As': [3405, 4030], 'seen': [3408], '2,': [3411, 3632, 4895, 4923], 'C': [3412, 4120, 4536, 4896], 'E,': [3414], 'amount': [3419, 4057], 'untreated': [3424, 3735, 4047, 4069], 'most': [3428], 'likely': [3429, 3844], 'due': [3430, 4567], 'background': [3433], 'plasmid,': [3439], 'access': [3442, 4332], 'even': [3445], 'illustrated': [3493], 'ratio': [3499], '529': [3502], 'bp': [3503], '(Me).': [3511], 'almost': [3520, 3644, 3753, 4043], 'TSA.': [3527], '2B': [3529], 'confirms': [3530, 4930], 'under': [3535], 'conditions,': [3537], 'get': [3540], 'de': [3541], 'novo': [3542], 'presence': [3550, 4581], 'suggesting': [3559], 'activity.': [3567, 4146], 'dependent': [3574, 4141, 4905], 'inhibitory': [3577, 4145, 4170, 4813], 'properties': [3578], 'compare': [3586], 'those': [3592], 'D': [3633, 4924], 'F,': [3635, 4235], 'illustrates': [3636], 'although': [3638, 5551, 5655], '50%': [3645, 4529, 5053], 'concentration': [3649], 'virtually': [3653], 'no': [3654, 4112, 4920], 'effect.': [3655], 'Together,': [3656], 'ability': [3667, 4126], 'hyperacetylation,': [3671], 'inducer': [3674], 'bisulfite': [3687], 'analysis,': [3688], 'determines': [3690], 'single': [3695], 'base': [3696], 'resolution': [3697], '(28Clark': [3698], 'S.J.': [3699], 'Harrison': [3700], 'Paul': [3702], 'C.L.': [3703], 'Frommer': [3704], '2990-2997Crossref': [3711], '(1622)': [3714], 'analyses,': [3721], '2G,': [3725], 'reveal': [3726], 'retains': [3730], '(filled': [3739], 'circles': [3740], 'represent': [3741], 'CpGs).': [3743], 'sites': [3761, 3774, 3831], '(open': [3765], 'circles),': [3766], 'exception': [3769], 'clones.': [3777, 3827], 'clear': [3781, 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