Cain, A Novel Physiologic Protein Inhibitor of Calcineurin

Name: Work Video:
Duration: 3 min 30 s
Michael M. Lai; Patrick E. Burnett; Herman Wolosker; Seth Blackshaw; Solomon H. Snyder
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3688, 3829, 3896, 3921, 3928, 4044, 4112, 4186, 4206, 4243, 4270, 4383, 4420, 4541, 4595, 4620, 4633, 4683, 4703, 4815, 4997, 5020, 5043, 5081, 5176, 5260], 'widely': [3, 178], 'distributed': [4, 179], 'protein': [5, 99, 180, 274, 354, 822, 1203, 1797, 1807, 1812, 1815, 1935, 1979, 2358, 2878, 3160, 3167, 3194, 3255, 3473, 3807, 3922, 5022, 5065, 5114, 5117], 'phosphatase': [6, 181, 355, 1160, 1510, 5134, 5203], 'regulated': [7, 182], 'by': [8, 137, 183, 312, 357, 543, 969, 1031, 1144, 1156, 2148, 2220, 2267, 2290, 2336, 2465, 2489, 2541, 2749, 2842, 2936, 2955, 3045, 3062, 3082, 3332, 3378, 3439, 3557, 3576, 3650, 3885, 3967, 4009, 4144, 4149, 4174, 4322, 4339, 4841, 4942], 'calcium': [9, 184, 358, 1072, 1632, 1757, 2542], 'and': [10, 22, 24, 43, 65, 77, 89, 115, 151, 185, 197, 199, 218, 240, 252, 264, 290, 326, 359, 464, 476, 495, 563, 769, 816, 1051, 1149, 1242, 1403, 1478, 1615, 1617, 1721, 1814, 1843, 1926, 1941, 1958, 1977, 1992, 2012, 2084, 2107, 2128, 2130, 2137, 2261, 2327, 2349, 2397, 2463, 2473, 2482, 2527, 2552, 2634, 2674, 2681, 2697, 2713, 2734, 2751, 2790, 2844, 2882, 2918, 2953, 2996, 3015, 3030, 3047, 3068, 3078, 3095, 3109, 3155, 3185, 3205, 3225, 3239, 3267, 3273, 3283, 3319, 3348, 3365, 3394, 3434, 3503, 3512, 3524, 3548, 3564, 3572, 3581, 3593, 3616, 3627, 3642, 3681, 3696, 3715, 3751, 3762, 3785, 3834, 3890, 4017, 4111, 4215, 4245, 4303, 4354, 4372, 4417, 4425, 4456, 4462, 4469, 4479, 4492, 4510, 4517, 4549, 4560, 4571, 4581, 4586, 4600, 4627, 4670, 4677, 4690, 4794, 4837, 4937, 5068, 5074, 5116, 5133, 5213, 5220, 5266, 5275], 'calmodulin.': [11, 186, 4166], 'It': [12, 187, 1882], 'mediates': [13, 188], 'the': [14, 35, 62, 66, 73, 160, 172, 189, 210, 237, 241, 248, 335, 347, 360, 406, 486, 539, 633, 640, 772, 863, 963, 976, 1025, 1077, 1248, 1442, 1474, 1502, 1509, 1533, 1566, 1575, 1610, 1636, 1722, 1756, 1886, 1895, 1903, 1924, 1972, 2015, 2068, 2077, 2092, 2097, 2101, 2144, 2165, 2211, 2278, 2338, 2343, 2347, 2363, 2388, 2449, 2645, 2653, 2662, 2664, 2740, 2769, 2794, 2869, 2873, 2937, 2956, 2978, 2982, 3031, 3093, 3130, 3142, 3145, 3172, 3179, 3198, 3206, 3228, 3244, 3251, 3257, 3263, 3270, 3315, 3322, 3346, 3361, 3368, 3392, 3400, 3412, 3421, 3430, 3450, 3471, 3475, 3499, 3535, 3577, 3589, 3617, 3630, 3634, 3660, 3672, 3684, 3758, 3764, 3773, 3804, 3824, 3874, 3893, 3954, 3969, 3974, 3983, 3997, 4034, 4049, 4061, 4074, 4092, 4127, 4136, 4139, 4160, 4170, 4183, 4192, 4287, 4313, 4324, 4335, 4346, 4380, 4436, 4442, 4453, 4460, 4482, 4535, 4556, 4566, 4590, 4608, 4630, 4637, 4694, 4770, 4797, 4825, 4833, 4842, 4851, 4963, 5007, 5033, 5047, 5051, 5076, 5131, 5224, 5233, 5249, 5269], 'immunosuppressive': [15, 190, 1578], 'actions': [16, 191], 'of': [17, 31, 40, 45, 80, 123, 130, 165, 192, 206, 215, 220, 255, 298, 305, 340, 443, 488, 541, 569, 635, 642, 645, 775, 820, 926, 966, 978, 1070, 1076, 1138, 1152, 1239, 1244, 1437, 1476, 1489, 1505, 1536, 1577, 1613, 1848, 1890, 1897, 1905, 1928, 2046, 2143, 2254, 2280, 2352, 2372, 2378, 2387, 2403, 2493, 2595, 2608, 2807, 2820, 2876, 2939, 2958, 3038, 3098, 3144, 3175, 3200, 3230, 3286, 3296, 3300, 3303, 3336, 3351, 3382, 3397, 3414, 3423, 3452, 3493, 3501, 3537, 3579, 3614, 3636, 3648, 3662, 3674, 3727, 3737, 3760, 3766, 3775, 3813, 3842, 3859, 3895, 3923, 3932, 3939, 3956, 3993, 4033, 4038, 4073, 4081, 4094, 4116, 4141, 4162, 4165, 4172, 4178, 4185, 4209, 4279, 4291, 4312, 4317, 4349, 4414, 4452, 4459, 4467, 4477, 4579, 4625, 4686, 4700, 4742, 4748, 4773, 4789, 4844, 4854, 4940, 4966, 4979, 5050, 5057, 5083, 5136, 5167, 5223, 5252, 5262, 5268], 'drugs': [18, 193, 490, 545, 1579], 'such': [19, 194, 491, 980, 1634], 'as': [20, 195, 492, 566, 649, 981, 1228, 1622, 1635, 1851, 1853, 2017, 2229, 2295, 2361, 2659, 2686, 2754, 2840, 2884, 3111, 3459, 3470, 4711, 4814, 4828, 4968, 5019, 5120, 5122, 5149, 5164], 'cyclosporin': [21, 196, 493, 767], 'FK506,': [23, 198, 3453, 3761, 5263], 'has': [25, 146, 200, 321, 859, 1344, 3808, 4745], 'been': [26, 201, 1321, 1492, 5157], 'implicated': [27, 202, 1322], 'in': [28, 34, 48, 113, 116, 159, 203, 209, 223, 288, 291, 334, 412, 415, 485, 806, 813, 823, 862, 869, 1161, 1205, 1247, 1323, 1481, 1534, 1574, 1765, 1907, 2135, 2394, 2459, 2554, 2638, 2656, 2676, 2708, 2739, 2762, 2776, 2889, 2962, 2998, 3104, 3141, 3227, 3256, 3269, 3290, 3292, 3355, 3411, 3449, 3474, 3498, 3534, 3597, 3633, 3687, 3700, 3732, 3757, 3770, 3792, 3892, 3973, 4010, 4059, 4091, 4159, 4182, 4189, 4212, 4223, 4257, 4301, 4343, 4351, 4379, 4435, 4441, 4496, 4522, 4528, 4572, 4583, 4607, 4615, 4629, 4713, 4970, 4976, 5046, 5059, 5181], 'number': [30, 205], 'calcium-sensitive': [32, 207, 1909], 'pathways': [33, 208], 'nervous': [36, 211, 864], 'system,': [37, 212, 865, 3477, 3986], 'including': [38, 57, 213, 232, 1085, 4555], 'regulation': [39, 214], 'neurotransmitter': [41, 216], 'release': [42, 217, 977, 5199], 'modulation': [44, 219], 'long-term': [46, 221, 1245, 1438, 1447], 'changes': [47, 222, 1764, 4969], 'synaptic': [49, 224, 879, 1198, 1207, 1325, 1350], 'plasticity.': [50, 225, 1199], 'associates': [52, 109, 227, 284, 1570], 'physiologically': [53, 228, 1937, 3699, 4546, 4985], 'with': [54, 88, 100, 110, 229, 263, 275, 285, 483, 1571, 1939, 2126, 2273, 2406, 2446, 2455, 2475, 2523, 2600, 2617, 2626, 2671, 2736, 2774, 2928, 2981, 3070, 3250, 3408, 3457, 3466, 3485, 3606, 3666, 3772, 3927, 3947, 3960, 4001, 4103, 4236, 4286, 4326, 4548, 4682, 5030, 5241], 'other': [55, 230, 4225], 'proteins,': [56, 231, 3739], 'calmodulin,': [58, 233, 2917, 4153], 'FKBP12': [59, 234, 477, 1569, 1614, 1619, 1627, 2153, 3140, 3215, 3224, 3247, 3253, 3266, 3409, 3448, 3549, 3582, 4373, 4478, 4486, 4502], '(FK506-binding': [60, 235, 478], 'protein),': [61, 236, 1804], 'ryanodine': [63, 238, 1637], 'receptor,': [64, 239], 'inositol': [67, 242, 1723], '1,4,5-trisphosphate': [68, 243, 1724], 'receptor.': [69, 244], 'We': [70, 245, 1921, 3148, 3241, 3611, 3691, 3747, 4167, 4574, 4951, 5209, 5226], 'now': [71, 246, 1922], 'report': [72, 247, 1923], 'identification,': [74, 249], 'molecular': [75, 250, 3811, 3930, 4289], 'cloning,': [76, 251], 'functional': [78, 253, 4384], 'characterization': [79, 254, 1927], 'novel': [82, 257, 4542], 'protein,': [83, 258, 4543], 'cain': [84, 94, 145, 259, 269, 320, 1929, 2093, 2339, 2514, 2771, 2984, 3079, 3176, 3406, 3433, 3486, 3523, 3547, 3573, 3592, 3695, 3719, 3750, 3768, 3784, 3806, 3825, 3860, 3957, 3994, 4018, 4039, 4082, 4145, 4175, 4210, 4350, 4364, 4424, 4468, 4491, 4516, 4580, 4599, 4669, 4774, 4790, 4836, 4943, 4984, 4995, 5039, 5058, 5073, 5125, 5140, 5144, 5153, 5163, 5188, 5235], '(calcineurininhibitor),': [85, 260], 'that': [86, 164, 261, 339, 473, 1147, 1430, 1808, 1885, 1936, 3137, 3243, 3405, 3429, 3455, 3540, 3743, 3749, 3763, 3803, 3958, 3995, 4031, 4060, 4072, 4126, 4138, 4169, 4363, 4476, 4565, 4674, 4805, 4810, 4832, 4955, 4994, 5035, 5066], 'interacts': [87, 262, 1938, 3959, 4547], 'inhibits': [90, 265, 1432, 1508, 1943, 4550, 4680, 5069], 'calcineurin.': [91, 266, 3525, 3566, 4480, 4551, 4701, 4950, 5028, 5070, 5123], 'The': [92, 126, 267, 301, 471, 1136, 2001, 2150, 2215, 2356, 2512, 2689, 2726, 2835, 3326, 3372, 3491, 3567, 3638, 3725, 3781, 3856, 3868, 3914, 4277, 4465, 4739, 4935], 'full-length': [93, 268, 2069, 2151, 3857, 4075, 4239, 4292, 4314, 5234], 'cDNA': [95, 270, 2177, 2760, 2821, 2829, 3153, 3832, 3843, 3858], 'predicts': [96, 271], '240-kDa': [98, 273], 'no': [101, 276, 1560, 3543, 3849, 3944, 4974], 'significant': [102, 277, 3945], 'homology': [103, 278, 3163, 3946], 'to': [104, 119, 279, 294, 778, 1096, 1446, 1496, 1539, 1620, 1630, 1763, 1846, 1856, 2172, 2322, 2329, 2384, 2399, 2438, 2498, 2642, 2644, 2652, 2722, 2832, 2868, 2977, 3134, 3164, 3192, 3339, 3343, 3385, 3389, 3447, 3664, 3734, 3873, 3999, 4022, 4043, 4152, 4345, 4506, 4512, 4692, 4791, 4819, 4850, 5006, 5009, 5024, 5038, 5042, 5061, 5139, 5174, 5193, 5205], 'any': [105, 280, 3165, 3948], 'known': [106, 281, 648, 1795, 3166, 4697], 'protein.': [107, 282, 1626, 3442, 3951, 4315, 5000, 5052], 'Cain': [108, 283, 2086, 4097, 4679, 4817, 5016], 'calcineurin': [111, 124, 286, 299, 484, 565, 765, 809, 927, 1157, 1431, 1477, 1490, 1537, 1624, 1629, 1799, 1842, 1849, 1898, 1906, 1940, 2071, 2381, 2922, 3444, 3458, 3511, 3571, 3594, 3619, 3628, 3643, 3649, 3667, 3682, 3697, 3710, 3752, 3777, 3786, 4002, 4016, 4035, 4084, 4089, 4100, 4142, 4173, 4426, 4470, 4493, 4518, 4525, 4582, 4601, 4626, 4671, 4676, 4681, 4706, 4743, 4799, 4820, 4838, 4858, 4941, 4980, 5036, 5180, 5192], 'both': [112, 287, 1032, 3679, 4490, 4520, 4584, 4611, 4792, 5072], 'vitro': [114, 289, 4011, 4102, 4570], 'vivo,': [117, 292], 'leading': [118, 293], 'non-competitive': [121, 296, 4130], 'inhibition': [122, 297, 1847, 4105, 4128, 4140, 4157, 4171, 4193, 4939, 4978], 'activity.': [125, 300, 1946, 4981], 'putative': [127, 302, 5077], 'calcineurin-binding': [128, 303, 5078], 'domain': [129, 304, 1504, 4965], 'cain,': [131, 306, 4415, 4544], '38-amino': [133, 308, 4045, 4066], 'acid': [134, 309, 2961, 3159, 4046, 4067, 5086], 'region': [135, 310, 3955, 4047], 'defined': [136, 311], 'mutational': [138, 313], 'analysis,': [139, 314, 3182, 4203, 4341], 'highly': [141, 316, 4375], 'basic.': [142, 317], 'Like': [143, 318], 'calcineurin,': [144, 166, 319, 341, 1319, 1572, 1616, 1971, 3538, 3961, 4416, 4855, 4967, 5168], 'prominent': [148, 323, 4300, 4440], 'neuronal': [149, 324, 814, 1086, 1092, 1857], 'expression': [150, 157, 325, 332, 2161, 2289, 2521, 3204, 4332, 4427, 4434, 4672], 'wide': [153, 328], 'tissue': [154, 329, 2970, 3794, 5243], 'distribution.': [155, 330], "Cain's": [156, 331], 'pattern': [158, 333], 'brain': [161, 336, 824, 2705, 2759, 2828, 3705, 3831, 4585], 'closely': [162, 337, 4334], 'resembles': [163, 338], 'indicating': [167, 342, 3506], 'physiologic': [169, 344, 4577, 4596], 'association': [170, 345, 1612, 1840, 3431, 3509, 3569, 3736, 3782, 4578, 4834], 'between': [171, 346, 1237, 1565, 1841, 3223, 3265, 3432, 3510, 3522, 3546, 3570, 3591, 3640, 3783, 4386, 4423, 4598, 4623, 4636, 4668, 4675, 4835], 'two': [173, 348, 1567, 3201, 3886, 3989, 4388, 4638, 4798], 'proteins.': [174, 349, 1568], 'serine/threonine': [353], 'activated': [356], 'calmodulin-calcium': [361], 'complex': [362], '(1Stewart': [363], 'A.A.': [364], 'Ingebritsen': [365], 'T.S.': [366, 1002], 'Manalan': [367], 'A.': [368, 429, 619, 671, 696, 721, 786, 914, 1116, 1182, 1374, 1694, 1744, 2058, 2194, 2307, 4871], 'Klee': [369, 607, 1546, 2845, 2848, 5247], 'C.B.': [370, 384, 418, 608, 826, 1547, 2849], 'Cohen': [371, 5238], 'P.': [372, 884, 1006, 1650, 2196], 'FEBS': [373], 'Lett.': [374, 1380], '1982;': [375], '137:': [376], '80-84Crossref': [377], 'PubMed': [378, 433, 517, 533, 558, 581, 600, 623, 676, 703, 733, 797, 853, 918, 943, 956, 998, 1018, 1046, 1064, 1120, 1131, 1186, 1223, 1271, 1289, 1312, 1338, 1364, 1384, 1398, 1424, 1468, 1527, 1552, 1597, 1662, 1686, 1716, 1748, 1788, 1834, 1877, 2036, 2062, 2205, 2247, 2311, 3122, 3909, 4406, 4656, 4734, 4766, 4898, 4930, 5106], 'Scopus': [379, 434, 518, 534, 559, 582, 601, 624, 677, 704, 734, 759, 798, 854, 896, 919, 957, 1019, 1047, 1065, 1121, 1132, 1187, 1224, 1272, 1290, 1339, 1365, 1385, 1425, 1469, 1553, 1598, 1717, 1749, 1789, 1835, 1878, 2063, 2206, 2248, 2312, 3910, 4407, 4657, 4735, 4899, 4931, 5107], '(339)': [380], 'Google': [381, 398, 436, 520, 536, 561, 584, 603, 626, 679, 706, 736, 761, 800, 840, 856, 898, 921, 944, 959, 999, 1021, 1049, 1067, 1123, 1134, 1189, 1226, 1274, 1292, 1313, 1341, 1367, 1387, 1399, 1427, 1471, 1528, 1555, 1600, 1663, 1687, 1719, 1751, 1791, 1837, 1880, 2037, 2065, 2208, 2250, 2314, 3123, 3912, 4409, 4659, 4737, 4767, 4901, 4933, 5109], 'Scholar,': [382, 521, 585, 604, 680, 707, 737, 841, 899, 945, 1000, 1124, 1275, 1293, 1368, 1388, 1664, 1688, 4902], '2Klee': [383], 'Draetta': [385, 827], 'G.F.': [386, 828], 'Hubbard': [387, 829, 2843], 'M.J.': [388, 593, 830, 2847, 4914], 'Adv.': [389, 831], 'Enzymol.': [390, 832], 'Relat.': [391, 833], 'Areas': [392, 834], 'Mol.': [393, 697, 835], 'Biol.': [394, 699, 723, 749, 836, 935, 990, 1303, 1519, 1654, 1678, 3905, 4758], '1988;': [395, 837], '61:': [396, 838], '149-200PubMed': [397, 839], 'Scholar).': [399, 437, 627, 762, 801, 857, 960, 1022, 1068, 1135, 1190, 1314, 1342, 1400, 1472, 1529, 1601, 1752, 1792, 1838, 1881, 2038, 2251, 2315, 3124, 3913, 4410, 4738, 4768, 4934, 5110], 'This': [400, 1602, 2169, 2533, 3169, 3553, 3881, 4006, 4055, 4231], 'enzyme': [401], 'was': [402, 410, 1948, 1987, 1995, 2006, 2040, 2157, 2170, 2334, 2359, 2436, 2516, 2536, 2649, 2692, 2706, 2729, 2766, 2788, 2799, 2823, 2837, 2880, 2974, 3021, 3054, 3330, 3376, 3496, 3574, 3730, 3871, 4007, 4195], 'first': [403, 3875], 'purified': [404, 1969, 2373, 2379, 3516, 3527, 3565, 4015, 4095, 4265], 'from': [405, 1444, 1607, 1951, 1963, 1983, 1989, 1997, 2067, 2091, 2096, 2342, 2793, 2989, 3040, 3088, 3823, 3862, 4251, 4824, 4962], 'brain,': [407, 4213, 4381, 4609, 4631], 'where': [408, 866, 4485, 4610, 5197], 'it': [409, 803, 867, 4806, 5002, 5011], 'found': [411, 3404, 3479, 3748, 3988, 4168], 'high': [413], 'concentrations': [414, 4164], 'neurons': [416], '(3Klee': [417], 'Crouch': [419], 'T.H.': [420], 'Krinks': [421], 'M.H.': [422], 'Proc.': [423, 613, 908, 1110, 1176, 1738, 2052, 2301], 'Natl.': [424, 614, 909, 1111, 1177, 1739, 2053, 2302], 'Acad.': [425, 615, 910, 1112, 1178, 1740, 2054, 2303], 'Sci.': [426, 616, 846, 911, 1113, 1179, 1331, 1741, 2055, 2304], 'U.': [427, 617, 912, 1114, 1180, 1742, 2056, 2232, 2305], 'S.': [428, 618, 739, 913, 1115, 1181, 1355, 1357, 1646, 1676, 1743, 1827, 2057, 2234, 2306, 3114], '1979;': [430], '76:': [431], '6270-6273Crossref': [432], '(610)': [435], 'heterodimer': [441], 'consisting': [442], '60-kDa': [445, 454], 'catalytic': [446, 455, 1945, 4085], 'subunit': [447, 469, 2875], '(CnA)': [448], '1The': [449], 'abbreviations': [450], 'used': [451, 2171, 2693, 2883, 3191], 'are:': [452], 'CnA,': [453, 1497, 3077], 'subunit;': [456, 461], 'CaB,': [457], '19-kDa': [458, 466], 'calcium-binding': [459, 467], 'regulatory': [460, 468, 1915, 4947], 'NMDA,': [462], 'N-methyl-d-aspartate.': [463], '(CnB).': [470], 'discovery': [472], 'immunophilins': [474], 'cyclophilin': [475], 'protein)': [479], 'form': [480], 'inhibitory': [481, 4771], 'complexes': [482], 'presence': [487, 2279, 3143, 3229, 3413, 3451, 3536, 3635, 3673, 3759, 4093, 4161, 4184], 'immunophilin-binding': [489], 'A': [494, 768, 1200, 2252, 2783, 2805, 2865, 2966, 3839, 3937, 4122], 'FK506': [496, 770, 1947, 2627, 2648, 3233, 3297, 3415, 3502, 3580], '(4Liu': [497], 'J.': [498, 505, 523, 589, 657, 713, 722, 748, 934, 989, 1393, 1518, 1591, 1593, 1653, 1677, 2031, 2238, 2853, 3117, 3903, 4757], 'Farmer': [499], 'Jr.,': [500, 2189], 'J.D.': [501, 1215, 1217, 1829, 1872, 4729, 5101], 'Lane': [502, 691], 'W.S.': [503, 692], 'Friedman': [504], 'Weissman': [506, 524], 'I.': [507, 525, 1041], 'Schreiber': [508], 'S.L.': [509, 547], 'Cell.': [510, 526, 698, 1262, 1415, 1459, 1709, 1781, 4923], '1991;': [511, 527, 1117], '66:': [512, 528], '807-815Abstract': [513], 'Full': [514, 530, 555, 728, 730, 754, 756, 850, 891, 893, 940, 995, 1266, 1268, 1307, 1309, 1335, 1419, 1421, 1463, 1465, 1524, 1659, 1683, 1713, 1785, 4763, 4927], 'Text': [515, 531, 556, 729, 731, 755, 757, 851, 892, 894, 941, 996, 1267, 1269, 1308, 1310, 1336, 1420, 1422, 1464, 1466, 1525, 1660, 1684, 1714, 1786, 4764, 4928], 'PDF': [516, 532, 557, 732, 758, 852, 895, 942, 997, 1270, 1311, 1337, 1423, 1467, 1526, 1661, 1685, 1715, 1787, 4765, 4929], '(3620)': [519], '5Friedman': [522], '799-806Abstract': [529], '(361)': [535], 'Scholar)': [537, 1050, 1428, 1720, 2066, 2861], 'explained': [538, 4148], 'mechanism': [540], 'immunosuppression': [542], 'these': [544, 1760, 4318, 4387], '(6Schreiber': [546], 'Crabtree': [548, 575], 'G.R.': [549, 576, 931, 986, 1173], 'Immunol.': [550, 793], 'Today.': [551], '1992;': [552, 578, 597, 620, 1128, 1656, 2059, 2308], '13:': [553, 1595, 2034], '136-142Abstract': [554], '(1968)': [560], 'Scholar),': [562, 922, 1227, 1556, 2209], 'established': [564, 1211, 4705], 'mediator': [568], 'T': [570, 654, 782], 'cell': [571, 783, 1093, 2596, 2646, 2654], 'activation': [572, 784, 1151, 3199], '(7Clipstone': [573], 'N.A.': [574], 'Nature.': [577, 596, 672, 1042, 1360, 1548, 2201, 4894], '357:': [579, 598], '695-697Crossref': [580], '(1476)': [583], "8O'Keefe": [586], 'S.J.': [587, 612, 747], 'Tamura': [588], 'Kincaid': [590], 'R.L.': [591], 'Tocci': [592], "O'Neill": [594], 'E.A.': [595], '692-694Crossref': [599], '(788)': [602], '9Fruman': [605], 'D.A.': [606, 741], 'Bierer': [609, 744], 'B.E.': [610, 745, 1706], 'Burakoff': [611, 746], '89:': [621, 2060, 2309], '3686-3690Crossref': [622], '(755)': [625], 'activity': [629, 877, 965, 1026, 1137, 1241, 1511, 1754, 4037, 4090, 4143, 4859, 5204], 'necessary': [631], 'for': [632, 1202, 1562, 1798, 1917, 2269, 2287, 2443, 2611, 2628, 2719, 2801, 2950, 3027, 3075, 3103, 3646, 3717, 3920, 4064, 5152, 5179, 5216, 5231, 5239, 5248, 5259, 5272], 'synthesis': [634], 'several': [636, 1082, 4561], 'cytokine': [637], 'genes': [638], 'through': [639, 1759], 'dephosphorylation': [641, 1148], 'family': [644], 'transcription': [646], 'factors': [647], 'NF-AT': [650, 776], '(nuclear': [651], 'factor': [652], 'ofactivated': [653], 'cells)': [655], '(10Jain': [656], 'McCaffrey': [658, 687], 'P.G.': [659, 688, 694, 790], 'Miner': [660], 'Z.': [661, 1008], 'Kerppola': [662], 'T.K.': [663], 'Lambert': [664], 'J.N.': [665], 'Verdine': [666], 'G.L.': [667], 'Curran': [668], 'T.': [669, 905, 1251, 1281, 1640, 1702, 2236], 'Rao': [670, 695, 720], '1993;': [673, 1183, 1680, 2033], '365:': [674], '352-355Crossref': [675], '(679)': [678], '11Luo': [681], 'C.': [682, 709, 717, 788, 1010, 1583, 2026], 'Burgeon': [683], 'E.': [684, 1668, 1670, 1696, 1698], 'Carew': [685, 712], 'J.A.': [686, 4912], 'Badalian': [689], 'T.M.': [690, 1165, 1412, 1819, 2024, 4391, 4641], 'Hogan': [693, 789], '1996;': [700, 725, 751, 888, 1220, 1286, 1381, 1549, 1831, 2244], '16:': [701, 889], '3955-3966Crossref': [702], '(173)': [705], '12Loh': [708], 'Shaw': [710], 'K.T.': [711], 'Viola': [714], 'J.P.': [715, 947, 1167, 1729, 1772, 4393, 4643, 4904], 'Luo': [716, 787], 'Perrino': [718, 1514, 1861, 4718, 4753, 5090], 'B.A.': [719, 1515, 1862, 4719, 4754, 5091], 'Chem.': [724, 750, 936, 991, 1520, 1655, 1679, 4759], '271:': [726, 752, 1832], '10884-10891Abstract': [727], '(266)': [735], '13Wesselborg': [738], 'Fruman': [740], 'Sagoo': [742], 'J.K.': [743], '1247-1274Abstract': [753], '(90)': [760], 'By': [763], 'inhibiting': [764, 4857], 'activity,': [766, 1500, 1850, 4086], 'prevent': [771], 'nuclear': [773], 'translocation': [774], 'secondary': [777, 1095, 1538, 1762, 3741], 'dephosphorylation,': [779], 'thereby': [780, 974, 4856], 'suppressing': [781], '(14Rao': [785], 'Annu.': [791], 'Rev.': [792], '1997;': [794, 847, 915, 1263, 1304, 1332, 1395, 3119], '15:': [795], '707-747Crossref': [796], '(2223)': [799], 'Although': [802, 5159], 'expressed': [805], 'many': [807, 870, 1482], 'tissues,': [808], 'most': [811, 4591, 4695, 4959], 'concentrated': [812], 'systems,': [815], 'comprises': [817], 'over': [818], '1%': [819], 'total': [821, 2253, 2806], '(2Klee': [825], '15Yakel': [842], 'J.L.': [843, 1171, 1328, 4906], 'Trends': [844, 1329], 'Pharmacol.': [845, 1330], '18:': [848, 1333], '124-134Abstract': [849, 1334], '(224)': [855, 1340], 'diverse': [860], 'roles': [861], 'participates': [868], 'calcium-regulated': [871, 5202], 'pathways.': [872, 5208], 'Dynamin': [873], 'I,': [874, 3417, 3488], 'whose': [875], 'GTPase': [876, 964], 'regulates': [878, 1024, 1755], 'vesicle': [880], 'recycling': [881], '(16De': [882], 'Camilli': [883], 'Takei': [885], 'K.': [886, 1376, 1692, 1823, 4920], 'Neuron.': [887], '2479-2487Abstract': [890], '(189)': [897], '17Urrutia': [900], 'R.': [901, 1261, 1587, 4891], 'Henley': [902], 'J.R.': [903], 'Cook': [904], 'McNiven': [906], 'M.A.': [907, 4916, 4922], '94:': [916], '377-384Crossref': [917], '(255)': [920], 'substrate': [925, 2942], '(18Nichols': [928, 983], 'R.A.': [929, 984], 'Suplick': [930, 985], 'Brown': [932, 987], 'J.M.': [933, 988], '1994;': [937, 953, 992, 1043, 1361, 1594, 1710, 4403, 4653], '269:': [938, 993], '23817-23823Abstract': [939, 994], '19Liu': [946], 'Sim': [948], 'A.T.': [949], 'Robinson': [950], 'P.J.': [951], 'Science.': [952, 1060, 1127, 1830, 1873, 4730, 5102], '265:': [954, 1522, 4761], '970-973Crossref': [955], '(183)': [958], 'modulates': [962], 'dynamin': [967], 'I': [968], 'altering': [970, 1033], 'its': [971, 1479, 1499, 1854, 1944, 4150, 5169, 5182, 5198], 'phosphorylation': [972, 1145, 1767, 2870, 5150], 'state,': [973], 'regulating': [975, 1324], 'neurotransmitters': [979], 'glutamate': [982, 1097, 1193], '20Sihra': [1001], 'Nairn': [1003], 'A.C.': [1004], 'Kloppenburg': [1005], 'Lin': [1007], 'Pouzat': [1009], 'Biochem.': [1011], 'Biophys.': [1012], 'Res.': [1013, 2243], 'Commun.': [1014], '1995;': [1015, 1061, 1745, 1782, 1874, 2202, 4731, 4895, 4924, 5103], '212:': [1016], '609-616Crossref': [1017], '(44)': [1020], 'ofN-methyl-d-aspartate': [1027], '(NMDA)': [1028], 'receptor': [1029, 1079, 1638, 1725], 'channels': [1030, 1633, 1761], 'their': [1034, 1766, 4603], 'ion': [1035], 'gating': [1036], 'properties': [1037], '(21Lieberman': [1038], 'D.N.': [1039], 'Mody': [1040], '369:': [1044, 1362], '235-239Crossref': [1045], '(433)': [1048], 'promoting': [1052], 'desensitization': [1053], '(22Tong': [1054], 'G.': [1055, 1672, 2192], 'Shepherd': [1056], 'D.': [1057, 1589, 2051, 2300], 'Jahr': [1058], 'C.E.': [1059], '267:': [1062, 1657, 1875, 4732, 5104], '1510-1512Crossref': [1063], '(353)': [1066], 'Elevation': [1069], 'intracellular': [1071, 1631, 5195], 'concentration': [1073, 4972], 'following': [1074, 2078, 2102, 2550], 'opening': [1075], 'NMDA': [1078, 1098, 1195], 'channel': [1080], 'activates': [1081], 'downstream': [1083], 'proteins': [1084, 1891, 2264, 2318, 2746, 3136, 3454, 3517, 3720, 4389, 4612, 4639, 5026, 5137], 'nitric': [1087, 1139, 1153], 'oxide': [1088, 1140, 1154], 'synthase,': [1089], 'which': [1090, 1440, 4218, 4545, 5010], 'influences': [1091, 1441, 4080], 'death': [1094], 'neurotoxicity': [1099, 1163], '(23Dawson': [1100], 'V.L.': [1101, 1169], 'Bredt': [1102], 'D.S.': [1103], 'Fotuhi': [1104, 4396, 4646], 'M.': [1105, 1255, 1295, 1410, 1452, 1704, 1864, 3902, 4397, 4399, 4647, 4649, 4721, 5093], 'Hwang': [1106], 'P.M.': [1107, 2049, 2298], 'Snyder': [1108, 1174, 1736, 1779, 2029, 2197, 3115, 4400, 4650, 5270], 'S.H.': [1109, 1175, 1737, 1780, 2030, 2185, 2198, 3116, 4401, 4651], '88:': [1118, 1264], '7797-7801Crossref': [1119], '(1840)': [1122], '24Choi': [1125], 'D.W.': [1126], '258:': [1129], '241-243Crossref': [1130], '(164)': [1133], 'synthase': [1141, 1155], 'diminished': [1143], 'so': [1146, 4802], 'subsequent': [1150, 4938], 'implicates': [1158], 'this': [1159, 1918, 3424, 3494, 3656, 3800, 4065, 4280, 4714, 4956, 5031, 5186], 'NMDA-mediated': [1162], '(25Dawson': [1164], 'Steiner': [1166, 1728, 1771, 1954, 4392, 4642, 5258], 'Dawson': [1168, 2023], 'Dinerman': [1170], 'Uhl': [1172], '90:': [1184], '9808-9812Crossref': [1185], '(512)': [1188], 'Besides': [1191], 'mediating': [1192, 1609], 'neurotoxicity,': [1194], 'receptors': [1196], 'influence': [1197], 'role': [1201, 1480, 1904, 5171], 'kinases': [1204], 'shaping': [1206], 'plasticity': [1208, 1326, 1351], 'well': [1210, 1794, 1852, 4704, 5004, 5121], '(26Roberson': [1212], 'E.D.': [1213], 'English': [1214], 'Sweatt': [1216], 'Learn.': [1218, 1284], 'Mem.': [1219, 1285], '3:': [1221, 1287], '1-24Crossref': [1222], '(99)': [1225], 'multiple': [1229, 1908, 2969, 4829, 5242], 'experimental': [1230, 4553], 'paradigms': [1231, 4554], 'have': [1232, 1320, 1491, 4539, 4952, 5154, 5161], 'demonstrated': [1233], 'close': [1235, 4621], 'correlation': [1236], 'reduction': [1238], 'kinase': [1240, 1813, 1816, 1980, 2879, 5115, 5118, 5132], 'impairment': [1243], 'potentiation': [1246], 'hippocampus': [1249, 4461], '(27Abel': [1250], 'Nguyen': [1252, 1278], 'P.V.': [1253, 1279], 'Barad': [1254], 'Deuel': [1256], 'T.A.S.': [1257], 'Kandel': [1258, 1282, 1300, 1413, 1455], 'E.R.': [1259, 1283, 1301, 1414, 1456], 'Bourtchouladze': [1260], '1-11Abstract': [1265], '(1043)': [1273], '28Huang': [1276], 'Y.-Y.': [1277], 'Abel': [1280], '74-85Crossref': [1288], '(197)': [1291], '29Mayford': [1294], 'Mansuy': [1296, 1407], 'I.M.': [1297, 1408, 1450], 'Muller': [1298], 'R.U.': [1299], 'Curr.': [1302], '7:': [1305], 'R580-R589Abstract': [1306], 'More': [1315], 'recently,': [1316], 'phosphatases,': [1317], 'especially': [1318], '(15Yakel': [1327], 'diverse,': [1345], 'sometimes': [1346], 'contradictory,': [1347], 'effects': [1348], 'on': [1349, 2277, 2872, 4083, 4282, 4949], '(30Mulkey': [1352], 'R.M.': [1353], 'Endo': [1354], 'Shenolikar': [1356], 'Malenka': [1358], 'R.C.': [1359], '486-488Crossref': [1363], '(905)': [1366], '31Lu': [1369], 'Y.F.': [1370], 'Hayashi': [1371], 'Y.': [1372, 1513, 4752], 'Moriwaki': [1373], 'Tomizawa': [1375], 'Matsui': [1377], 'H.': [1378, 1648, 2851], 'Neurosci.': [1379, 1394, 2032, 3118], '205:': [1382], '103-106Crossref': [1383], '(33)': [1386], '32Wang': [1389], 'J.H.': [1390, 2240], 'Kelly': [1391], 'P.T.': [1392], '17:': [1396, 3120], '4600-4611Crossref': [1397], 'Recently,': [1401], 'Winder': [1402], 'colleagues': [1404], '(33Winder': [1405], 'D.G.': [1406], 'Osman': [1409], 'Moallem': [1411], '1998;': [1416, 1460], '92:': [1417, 1461, 1746], '25-37Abstract': [1418], '(304)': [1426], 'discovered': [1429], 'novel,': [1434, 1933], 'intermediate': [1435], 'phase': [1436], 'potentiation,': [1439], 'transition': [1443], 'short-term': [1445], 'memory': [1448], '(34Mansuy': [1449], 'Mayford': [1451], 'Jacob': [1453], 'B.': [1454], 'Bach': [1457], 'M.E.': [1458, 1581], '39-49Abstract': [1462], '(322)': [1470], 'Despite': [1473], 'abundance': [1475, 4348, 4498], 'biologically': [1483], 'important': [1484], 'processes,': [1485], 'few': [1486], 'endogenous': [1487, 3214, 3245, 3504, 3618, 3709, 3738, 3805, 4698], 'regulators': [1488, 3462], 'identified.': [1493], 'Calmodulin,': [1494], 'bound': [1495, 3530, 3629, 3683, 3708, 3776], 'enhances': [1498], 'while': [1501, 4071], 'autoinhibitory': [1503, 4740], 'CnA': [1506, 2039, 3226, 3268, 3469, 4778, 4793], 'competitively': [1507], '(35Hashimoto': [1512, 4751], 'Soderling': [1516, 4755], 'T.R.': [1517, 4756], '1990;': [1521, 4760], '1924-1947Abstract': [1523, 4762], 'Superoxide': [1530], 'dismutase': [1531], 'prevents': [1532], 'vivoinactivation': [1535], 'oxidative': [1540], 'damage': [1541], '(36Wang': [1542], 'X.': [1543, 4885], 'Culotta': [1544], 'V.C.': [1545], '383:': [1550], '434-437Crossref': [1551], '(241)': [1554], 'but': [1557, 3676, 4217, 4438], 'there': [1558, 3541], 'evidence': [1561, 4593], 'direct': [1563, 3508, 3520, 3544, 3568], 'binding': [1564, 2368, 2407, 2435, 2456, 3558, 4012, 4036, 4151, 4562, 4788, 4936, 5037], 'even': [1573, 4473, 4665], 'absence': [1576, 3500], '(37Cardenas': [1580], 'Hemenway': [1582], 'Muir': [1584], 'R.S.': [1585], 'Ye': [1586], 'Fiorentino': [1588], 'Heitman': [1590], 'EMBO': [1592], '5944-5957Crossref': [1596], '(138)': [1599], 'interaction': [1603, 3222, 3264, 3277, 3425, 3482, 3495, 3521, 3545, 3590, 3639, 4385, 4567], 'involves': [1604], 'residues': [1605, 5087], 'distinct': [1606, 4823, 4961], 'those': [1608], 'FK506-dependent': [1611], 'allows': [1618, 3645], 'function': [1621, 5018], 'anchoring': [1625, 1796, 1803], 'targets': [1628], '(38Jayaraman': [1639], 'Brillantes': [1641], 'A.M.': [1642, 1727, 1770], 'Timerman': [1643], 'A.P.': [1644, 1666], 'Fleischer': [1645, 1675], 'Erdjument-Bromage': [1647], 'Tempst': [1649], 'Marks': [1651, 1673, 1707], 'A.R.': [1652, 1674, 1708], '9474-9477Abstract': [1658], '39Timerman': [1665], 'Ogunbumni': [1667], 'Freund': [1669], 'Wiederrecht': [1671], '268:': [1681], '22992-22999Abstract': [1682], '40Brillantes': [1689], 'A.B.': [1690], 'Ondrias': [1691], 'Scott': [1693, 1828, 1871, 4728, 5100], 'Kobrinsky': [1695], 'Ondrisova': [1697], 'Moschella': [1699], 'M.C.': [1700, 1821], 'Jayaraman': [1701], 'Landers': [1703], 'Ehrlich': [1705], '77:': [1711], '513-523Abstract': [1712], '(703)': [1718], '(41Cameron': [1726], 'Sabatini': [1730, 5265], 'D.M.': [1731], 'Kaplin': [1732], 'A.I.': [1733], 'Walensky': [1734], 'L.D.': [1735], '1784-1788Crossref': [1747], '(269)': [1750], 'flux': [1758], 'states': [1768], '(42Cameron': [1769], 'Roskams': [1773], 'A.J.': [1774], 'Ali': [1775], 'S.M.': [1776], 'Ronnett': [1777], 'G.V.': [1778], '83:': [1783], '463-472Abstract': [1784], '(451)': [1790], 'Another': [1793], 'AKAP79': [1801, 1844, 5111], '(Akinase': [1802], 'scaffolding': [1806, 5021], 'also': [1809, 2650, 3644, 3788, 4219, 4299, 4526, 4575, 5127, 5227], 'binds': [1810, 3445, 4818, 5067, 5112], 'cAMP-dependent': [1811, 1978, 2877, 5113], 'C': [1817, 4050, 5119], '(43Klauck': [1818], 'Faux': [1820], 'Labudda': [1822], 'Langeberg': [1824, 1865, 4722, 5094], 'L.K.': [1825, 1866, 4723, 5095], 'Jaken': [1826], '1589-1592Crossref': [1833], '(482)': [1836], 'Physical': [1839], 'leads': [1845], 'targeting': [1855], 'membranes': [1858], '(44Coghlan': [1859, 4716, 5088], 'V.M.': [1860, 4717, 5089], 'Howard': [1863, 4720, 5092], 'Hicks': [1867, 4724, 5096], 'J.B.': [1868, 4725, 5097], 'Gallatin': [1869, 4726, 5098], 'W.M.': [1870, 4727, 5099], '108-111Crossref': [1876, 4733, 5105], '(529)': [1879, 4736, 5108], 'unlikely': [1884], 'above': [1887], 'short': [1888], 'list': [1889], 'could': [1892, 3787, 5003, 5126], 'adequately': [1893], 'explain': [1894], 'diversity': [1896], 'function.': [1899], 'To': [1900, 3586, 3952, 4078, 4134], 'better': [1901], 'appreciate': [1902], 'signaling': [1910, 5207], 'pathways,': [1911], 'we': [1912, 3128, 3218, 3261, 3403, 3478, 3601, 3658, 3707, 3827, 3962, 3987, 4087, 4154, 4204, 4538, 4618, 4786, 5160], 'sought': [1913], 'additional': [1914, 3850], 'molecules': [1916], 'unique': [1919], 'phosphatase.': [1920], 'identification': [1925], '(calcineurin': [1930, 1975], 'inhibitor),': [1931], 'large': [1934, 5064], 'potently': [1942, 4098], 'gift': [1950, 5251, 5261], 'Dr.': [1952, 5245, 5256], 'Joseph': [1953, 5257], '(Guilford': [1955], 'Pharmaceutical).': [1956], 'Glutathione-Sepharose': [1957], 'calmodulin-Sepharose': [1959, 2604, 3675], 'beads': [1960, 2605, 2623, 2666, 2738, 4024], 'were': [1961, 1981, 2089, 2123, 2146, 2217, 2259, 2265, 2284, 2319, 2382, 2451, 2468, 2503, 2546, 2598, 2624, 2667, 2684, 2747, 2812, 2887, 2934, 2945, 2994, 3043, 3080, 3107, 3190, 4298, 4320], 'purchased': [1962, 1982, 1996], 'Pharmacia': [1964, 2140], 'Biotech.': [1965], 'Purified': [1966], 'human': [1967, 2070, 2152, 3252, 5253], 'FKBP12,': [1968, 3076, 3505, 4418], 'bovine': [1970, 2380, 2428, 2909, 2921], 'RII': [1973, 2874], 'peptide': [1974, 2866, 4741], 'substrate),': [1976], 'Sigma.': [1984], 'Anti-CnA': [1985], 'antibody': [1986, 1994, 2005, 2477, 2484, 2496, 2691, 2699, 4268, 4325], 'obtained': [1988, 2095, 3835], 'Transduction': [1990], 'Laboratories,': [1991], 'anti-CnB': [1993, 2483], 'Upstate': [1998], 'Biotechnology': [1999], 'Inc.': [2000], 'rabbit': [2002], 'polyclonal': [2003, 3058, 4266], 'anti-cain': [2004, 3059, 3723, 4267], 'raised': [2007], 'against': [2008], '(His)6-cain': [2009, 2332, 2374, 2929, 3528, 4327], '(described': [2010, 2711], 'below),': [2011], 'affinity-purified': [2013, 3057], 'using': [2014, 2076, 2100, 2505, 2768, 2825, 3056, 3721, 4014, 4263], 'immunogen': [2016], 'described': [2018, 2230, 2296, 2687, 2743, 2841, 2986, 3112], '(45Sharp': [2019], 'A.H.': [2020, 2187], 'McPherson': [2021], 'P.S.': [2022], 'Aoki': [2025], 'Campbell': [2027], 'K.P.': [2028], '3051-3063Crossref': [2035], 'subcloned': [2041, 2517], 'into': [2042, 2132, 2159, 2180, 2223, 2346, 2518, 2538, 2731, 3092, 3345, 3391], 'SalI': [2043, 2127, 2348, 3094, 3347, 3393], 'andNotI': [2044], 'sites': [2045, 2134, 2351, 3097, 3350, 3396], 'pPC86/97': [2047], '(46Chevray': [2048, 2297], 'Nathans': [2050, 2299], '5789-5793Crossref': [2061, 2310], '(480)': [2064, 2313], 'Aβ': [2072], 'open': [2073, 2154, 2785, 3085, 3916], 'reading': [2074, 2155, 2786, 3086, 3917, 5222], 'frame,': [2075], 'polymerase': [2079, 2103, 3845], 'chain': [2080, 2104, 3846], 'reaction': [2081, 2105, 3847], 'primers:': [2082], '5′-acgcgtcgaccatggccgccccggag-3′': [2083], '5′-ttttgcggccgctcactgggcagtatggtt-3′.': [2085], 'deletion': [2087, 3965, 3991, 4019], 'mutants': [2088, 3966, 3992, 4020], 'generated': [2090, 2335, 2800, 3081, 3331, 3377, 3963], 'fragment': [2094, 2340, 2515, 3161, 3170, 3335, 3381, 3529, 3971, 4068], 'two-hybrid': [2098, 2344, 2513, 2770, 3132, 3181, 3258, 3288, 3476, 3977, 3985, 4558], 'screen': [2099, 2173, 2345], 'primers': [2106], 'an': [2108, 2506, 2528, 2990, 3722, 3809, 4664, 4945, 5165], 'appropriate': [2109], 'vector': [2110, 2162, 2354, 2522, 2764], 'primer:': [2111], 'cain1518–1610,': [2112], '5′-ttttgcggccgccaggtgatggcagcagcc-3′;': [2113], 'cain1518–1683,': [2114], '5′-ttttgcggccgcgcctccactggccagcag-3′;': [2115], 'cain1518–1752,': [2116], '5′-ttttgcggccgcgtaggtggtgtgacggtg-3′;': [2117], 'cain1762–1810,': [2118], '5′-acgcgtcgaccagcatctcagaggagac-3′;': [2119], 'cain1715–1810,': [2120], '5′-acgcgtcgactcaaggcaaaactgagtc-3′.': [2121], 'Inserts': [2122], 'then': [2124, 2635], 'digested': [2125], 'NotI': [2129, 2350, 3096, 3349, 3395], 'cloned': [2131, 2158, 2179], 'corresponding': [2133, 2867, 3338, 3384], 'pPC86': [2136, 2181, 3089, 3320, 3366], 'pGEX-4T-2': [2138], '(Amersham': [2139], 'Biotech).': [2141], 'All': [2142, 4316], 'constructs': [2145], 'verified': [2147, 4008], 'sequencing.': [2149], 'frame': [2156, 2787, 3087, 3918], 'yeast': [2160, 2226, 3131, 3180, 3188, 3212, 3246, 3272, 3287, 3294, 3976, 3984, 4557], 'pPC97,': [2163], 'containing': [2164, 2210, 2892, 3213], 'GAL4': [2166, 2212, 3316, 3323, 3362, 3369], 'DNA-binding': [2167, 3317, 3363], 'domain.': [2168, 2214, 3325, 3371], 'rat': [2175, 2704, 2758, 2827, 2968, 2993, 3151, 3704, 3830], 'hippocampal': [2176, 3152], 'library': [2178, 2761, 3154, 3833], '(47Li': [2182], 'X.J.': [2183], 'Li': [2184], 'Sharp': [2186], 'Nucifora': [2188], 'F.C.': [2190], 'Schilling': [2191], 'Lanahan': [2193], 'Worley': [2195], 'Ross': [2199], 'C.A.': [2200], '378:': [2203, 4896], '398-402Crossref': [2204], '(540)': [2207], 'transactivation': [2213, 3324, 3370], 'plasmids': [2216], 'introduced': [2218, 2537], 'sequencially': [2219], 'LiAc-mediated': [2221], 'transformation': [2222], 'FKBP12-deficient': [2224, 3186, 3271, 3401], 'HF7C': [2225], 'strain,': [2227], 'constructed': [2228], '(48Guldener': [2231], 'Heck': [2233], 'Fielder': [2235], 'Beinhauer': [2237], 'Hegemann': [2239], 'Nucleic': [2241], 'Acids': [2242], '24:': [2245], '2519-2524Crossref': [2246], '(1362)': [2249], '1.5': [2255], '×': [2256, 2717, 2809, 3025], '106independent': [2257], 'clones': [2258, 2283, 2811, 3864], 'screened,': [2260, 2813], 'positive': [2262], 'interacting': [2263], 'identified': [2266, 3156, 4540, 5162], 'selecting': [2268], 'His+': [2270], 'growth': [2271], 'phenotype': [2272], 'strict': [2275], 'dependence': [2276], 'FK506.': [2281, 3147, 3637], 'Positive': [2282], 'further': [2285, 4953], 'evaluated': [2286, 3659], 'β-galactosidase': [2288, 3203, 3304], 'nitrocellulose': [2291, 2471], 'filter': [2292], 'lift': [2293], 'assays': [2294, 2658], 'GST': [2316], 'fusion': [2317, 2357], 'prepared': [2320, 2360, 3108], 'according': [2321, 2831, 2976], "manufacturer's": [2323, 2364, 2833, 2979], 'recommendations': [2324, 2980], '(Pharmacia': [2325], 'Biotech)': [2326], 'coupled': [2328, 4021], 'glutathione-Sepharose': [2330], 'beads.': [2331], 'construct': [2333, 2535], 'subcloning': [2337, 3083, 3333, 3379], 'isolated': [2341], 'pET-28c(+)': [2353], '(Novagen).': [2355], 'per': [2362], 'protocol.': [2365, 2834], 'In': [2366, 3125, 3178, 3211, 3671, 3798, 4241, 4411, 4481, 4534, 4783, 5185], 'each': [2367, 3084], 'assay,': [2369], '2': [2370, 2376, 2417, 2420, 2565, 2568, 3609, 3669, 3779], 'μg': [2371, 2377, 3037], 'and/or': [2375], 'added': [2383, 2651], '20': [2385, 2720, 3028], 'μl': [2386, 2405, 2607], 'GST-fusion': [2389], 'protein-Sepharose': [2390], 'slurry': [2391], '(50%': [2392], '(w/v)': [2393], 'phosphate-buffered': [2395, 3000], 'saline)': [2396], 'brought': [2398], 'final': [2401], 'volume': [2402], '200': [2404], 'buffer': [2408, 2556, 2640, 2673, 2710], '(50': [2409, 2557], 'mm': [2410, 2415, 2418, 2421, 2432, 2558, 2563, 2566, 2569, 2575, 2590, 2894, 2899, 2902, 2905, 2913], 'Tris-HCl,': [2411, 2559, 2895], 'pH': [2412, 2560, 2896], '7.4,': [2413, 2561, 2897], '100': [2414, 2562, 2898, 2915], 'NaCl,': [2416, 2564, 2900], 'CaCl2,': [2419, 2567, 2906], 'MgCl2,': [2422, 2570, 2903], '0.2%': [2423, 2571, 4710], 'Triton': [2424, 2572], 'X-100,': [2425, 2573], '0.5': [2426, 2431, 2574, 2912], 'mg/ml': [2427, 2908], 'serum': [2429, 2910], 'albumin,': [2430, 2911], 'β-mercaptoethanol).': [2433], 'After': [2434, 2924], 'allowed': [2437], 'proceed': [2439], 'at': [2440, 2479, 2485, 2614, 2631, 2694, 2700, 2715, 2930, 2947, 3023, 3065, 4107, 4273, 4821], '4': [2441, 2615, 2632, 2931, 3980, 4004, 4026, 4053], '°C': [2442, 2616, 2633, 2949], '1': [2444, 2580, 2589, 2612, 2629, 2925, 3006, 3016, 3231, 3238, 3551, 3584], 'h': [2445, 2549, 2613, 2630, 2926], 'gentle': [2447, 2618], 'mixing,': [2448], 'samples': [2450, 3042], 'washed': [2452, 2636, 2668], 'three': [2453, 2669], 'times': [2454, 2670], 'buffer,': [2457, 2462], 'boiled': [2458, 2675], 'SDS': [2460, 2677], 'sample': [2461, 2678], 'separated': [2464, 3044], 'SDS-PAGE.': [2466], 'Proteins': [2467], 'transferred': [2469, 3048], 'onto': [2470, 3049, 3620, 3711, 3754], 'membrane': [2472], 'immunoblotted': [2474], 'anti-T7': [2476], '(Novagen)': [2478], '1:10,000': [2480], 'dilution': [2481, 2492, 3067], '1:1,000': [2486], 'dilution,': [2487, 2696], 'followed': [2488, 3061], '1:5,000': [2491, 3066], 'anti-mouse': [2494], 'Ig': [2495, 3064], 'conjugated': [2497], 'horseradish': [2499], 'peroxidase.': [2500], 'Western': [2501, 2682, 2752, 4261], 'blots': [2502], 'visualized': [2504], 'enhanced': [2507], 'chemiluminescence': [2508], 'system': [2509, 2780, 3133, 4559], '(ECL,': [2510], 'Amersham).': [2511], 'mammalian': [2520, 3599], 'cytomegalovirus': [2525], 'promoter': [2526], 'in-frame': [2529, 3876, 3887], 'N-terminalmyc': [2530], 'epitope': [2531], 'tag.': [2532], 'myc-cain': [2534, 3607, 3615, 3626, 3663, 3680], 'HEK293': [2539, 3603], 'cells': [2540, 3604, 4509, 4530], 'phosphate-mediated': [2543], 'transfection.': [2544], 'Cells': [2545], 'harvested': [2547, 2995], '48': [2548], 'transfection': [2551], 'lysed': [2553], 'lysis': [2555, 2639, 2672, 2709], 'β-mercaptoethanol,': [2576], '5': [2577, 3003, 4120, 4132, 4199], 'μg/ml': [2578, 2581, 2584, 2587, 3004, 3007, 3010, 3013], 'aprotinin,': [2579, 3005], 'leupeptin,': [2582, 3008], '6': [2583, 2901, 3009, 4229, 4357], 'chymostatin,': [2585, 3011], '0.7': [2586, 3012], 'pepstatin,': [2588, 3014], 'phenylmethylsulfonyl': [2591], 'fluoride).': [2592], 'Equal': [2593, 3034], 'amounts': [2594, 3035], 'lysate': [2597, 2655, 2728], 'incubated': [2599, 2735], 'GST-Sepharose,': [2601, 3678], 'GST-FKBP12-Sepharose,': [2602], 'or': [2603, 3090, 3461, 4309, 4779], '(20': [2606], '50%': [2609], 'slurry)': [2610], 'agitation.': [2619], 'Where': [2620], 'indicated,': [2621], 'GST-FKBP12-Sepharose': [2622, 2737], 'preabsorbed': [2625], 'twice': [2637], 'prior': [2641], 'adding': [2643], 'lysate.': [2647], 'co-precipitation': [2657, 3613], 'indicated.': [2660, 2864], 'Following': [2661], 'incubation,': [2663], 'Sepharose': [2665], 'buffer.': [2679], 'SDS-PAGE': [2680, 2750, 3046, 4283], 'blotting': [2683, 2753], 'performed': [2685, 2824, 2888, 2946, 3055, 4155], 'above.': [2688, 2744, 2987], 'anti-myc': [2690], '1:3,000': [2695], 'anti-CnA': [2698], '1:250': [2701], 'dilution.': [2702], 'Adult': [2703], 'homogenized': [2707, 2997], 'above)': [2712], 'spun': [2714], '20,000': [2716], 'g': [2718, 3026], 'min': [2721, 2952, 3029], 'remove': [2723], 'insoluble': [2724], 'materials.': [2725], 'resulting': [2727, 4250], 'divided': [2730], 'equal': [2732], 'aliquots': [2733, 2891], 'same': [2741], 'manner': [2742], 'Bound': [2745], 'analyzed': [2748], 'described.': [2755], 'An': [2756], 'adult': [2757, 2991, 3703], 'λZAPII': [2763], '(Stratagene)': [2765], 'screened': [2767, 3149, 3828], 'fragment,': [2772], 'labeled': [2773], '32P': [2775], 'nick': [2778], 'translation': [2779, 3898], '(Boehringer': [2781], 'Mannheim).': [2782], '5.4-kilobase': [2784], 'identified,': [2789], 'probe': [2792, 2985], 'N-terminal': [2795, 2983], 'sequence': [2796, 3852, 3940, 4056], '(nucleotides': [2797], '41–1040)': [2798], 'second': [2803], 'screen.': [2804], '4.0': [2808], '106': [2810], 'yielding': [2814], '33': [2815, 3836], 'overlapping': [2816, 3837, 3863, 3990], 'inserts.': [2817], '5′-Rapid': [2818], 'amplification': [2819, 3841], 'ends': [2822, 3844], 'Marathon-Ready': [2826], '(CLONTECH)': [2830, 2973], 'assay': [2836, 3193], 'carried': [2838], 'out': [2839], '(49Hubbard': [2846], 'Wheal': [2850], 'Chad': [2852], 'Molecular': [2854], 'Neurobiology.': [2855], 'Oxford': [2856], 'University': [2857], 'Press,': [2858], 'Oxford1991:': [2859], '135-137Google': [2860], 'unless': [2862], 'otherwise': [2863], 'site': [2871, 4853, 4948, 4957, 5079, 5178], 'phosphorylated': [2881], 'substrate.': [2885], 'Assays': [2886, 2944], '50-μl': [2890], '40': [2893], '0.1': [2904, 2907, 2963], 'dithiothreitol,': [2914], 'nm': [2916, 2920], '25': [2919, 2948], '(Sigma).': [2923], 'preincubation': [2927], '°C,': [2932], 'reactions': [2933], 'started': [2935], 'addition': [2938, 2957, 3578, 4843], '2–150': [2940], 'μm': [2941, 3232, 4110, 4118, 4750], 'peptide.': [2943], '8': [2951], 'terminated': [2954], '5%': [2959], 'trichloroacetic': [2960], 'm': [2964], 'KH2PO4.': [2965], 'commercial': [2967], 'Northern': [2971, 4202, 4340], 'blot': [2972], 'hybridized': [2975], 'Tissues': [2988], 'male': [2992], 'ice-cold': [2999], 'saline': [3001], '+': [3002], 'mmphenylmethylsulfonyl': [3017], 'fluoride.': [3018], 'Each': [3019], 'homogenate': [3020], 'centrifuged': [3022], '16,000': [3024], 'pellet': [3032], 'discarded.': [3033], '(40': [3036], 'proteins)': [3039], 'all': [3041, 4032, 4224, 4258, 4457], 'polyvinylidene': [3050], 'difluoride': [3051], 'membrane.': [3052], 'Immunoblotting': [3053], 'antibody,': [3060], 'anti-rabbit': [3063], 'detected': [3069, 3219, 3790, 3972, 4205, 4222, 4256, 4576], 'ECL': [3071], 'reagents.': [3072], 'RNA': [3073], 'probes': [3074, 3821], 'pPC97': [3091, 3359], 'pBS(SK)II+': [3099], '(Stratagene).': [3100], 'Brain': [3101], 'slices': [3102], 'situ': [3105, 4412, 4661], 'hybridization': [3106, 4413, 4662], 'probed': [3110], '(50Blackshaw': [3113], '8074-8082Crossref': [3121], 'initial': [3126, 3975], 'experiments': [3127, 3559, 4361, 4785, 4830, 4992], 'utilized': [3129, 3602], 'identify': [3135], 'selectively': [3138], 'bind': [3139, 4813, 5128], 'drug': [3146], '300-amino': [3158], 'without': [3162], 'sequence.': [3168], 'constitutes': [3171], 'C-terminal': [3173, 5048], 'portion': [3174, 5049], '(calcineurininhibitor).': [3177], 'wild-type': [3183], 'HF7c': [3184, 3187], 'strains': [3189], 'interactions': [3195], 'based': [3196], 'upon': [3197, 4777, 5143], 'reporters,': [3202], 'more': [3207], 'sensitive': [3208], 'histidine': [3209], 'prototrophy.': [3210], '(wild-type': [3216], 'HF7c),': [3217], 'weak': [3221], '(HIS3+,': [3234, 3278, 3426, 3483], 'β-gal−)': [3235, 3427], '(Table': [3236, 3280, 3416, 3487], 'I,rows': [3237, 3281], '2).': [3240], 'reasoned': [3242], 'may': [3248, 3436, 3463, 4146, 5017, 5172, 5189], 'compete': [3249], 'bait': [3254, 3472], 'system;': [3259], 'accordingly,': [3260], 'assayed': [3262, 4088], 'observed': [3274], 'strong': [3276], 'β-gal+)': [3279, 3484], '3': [3282], '4).Table': [3284], 'ISummary': [3285], 'resultsProtein': [3289], 'pPC86Protein': [3291], 'pPC97Endogenous': [3293], 'FKBP12Presence': [3295], '(1': [3298], 'μm)Activation': [3299], 'HIS3': [3301], 'reporterActivation': [3302], 'reporter1FKBP12Calcineurin': [3305], 'A+−−−2FKBP12Calcineurin': [3306], 'A+++−3FKBP12Calcineurin': [3307], 'A−−−−4FKBP12Calcineurin': [3308], 'A−+++5CainFKBP12−−−−6CainFKBP12−++−7Cainp70S6K−−−−8Cainp70S6K−+−−9CainCalcineurin': [3309], 'A+−++10CainCalcineurin': [3310], 'A++++11CainCalcineurin': [3311], 'A−−++12CainCalcineurin': [3312], 'A−+++pPC97': [3313], 'contains': [3314, 3321, 3360, 3367, 3865, 5080], 'domain,': [3318, 3364], 'control': [3327, 3373], 'plasmid': [3328, 3374], 'pPC97-p70S6K': [3329, 3375], 'p70S6K,': [3337, 3383], 'amino': [3340, 3386, 3925, 5085], 'acids': [3341, 3387, 3926], '332': [3342, 3388], '504,': [3344, 3390], 'pPC97.': [3352, 3398], 'Open': [3353], 'table': [3354], 'new': [3357], 'tab': [3358], 'Using': [3399, 3468, 3655, 3702, 4201], 'yeast,': [3402], 'interacted': [3407], 'only': [3410, 3533, 3632], 'rows': [3418, 3489], '5–8).': [3419], 'However,': [3420, 4796, 5001], 'weakness': [3422], 'suggested': [3428, 4338], 'FKBP12/FK506': [3435, 4846], 'be': [3437, 3789, 4041, 4147, 4221, 4255, 4693, 5013, 5173], 'mediated': [3438], 'third': [3441], 'Since': [3443], 'tightly': [3446, 4803], 'associate': [3456, 3698], 'substrates': [3460], 'indirectly': [3464], 'interact': [3465, 4000], 'FKBP12/FK506.': [3467, 4845], 'robust': [3481], '9–12).': [3490], 'strength': [3492], 'unaltered': [3497, 3575, 4197, 4840], 'cain.': [3513, 4293], 'Experiments': [3514], 'utilizing': [3515, 3560], 'substantiate': [3518], 'Affinity': [3526], 'GST-FKBP12/FK506': [3531, 3622, 3712], 'resin': [3532, 3563, 3631, 3686, 3714], 'establishing': [3539, 4594], '(Fig.': [3550, 3583, 3608, 3668, 3778, 3935, 3979, 4003, 4025, 4052, 4119, 4131, 4198, 4228, 4356, 4428, 4499, 4531], 'A).': [3552, 3610, 3981, 4005, 4054, 4121, 4230, 4430], 'conclusion': [3554], 'supported': [3556], 'GST-cain': [3561], 'affinity': [3562, 3623, 3653, 3713, 4264], 'B).': [3585, 3670, 4027, 4133, 4358, 4501], 'ascertain': [3587, 3953], 'whether': [3588, 3694], 'takes': [3595], 'place': [3596], 'intact': [3598], 'cells,': [3600, 4524], 'transfected': [3605], 'monitored': [3612], 'resin.': [3624, 3654], 'Both': [3625, 4431], 'calmodulin': [3641, 3652, 3685, 4179, 4190, 4971], 'purification': [3647], 'resin,': [3657], 'ability': [3661, 3998], 'co-purify': [3665], 'not': [3677, 3740, 3796, 3854, 4329, 4369, 4511, 4808, 5147, 5155], 'FK506-independent': [3689], 'manner.': [3690], 'next': [3692], 'examined': [3693, 4227], 'tissues.': [3701, 4588], 'homogenate,': [3706], 'looked': [3716], 'co-precipitating': [3718], 'antibody.': [3724], 'amount': [3726, 3765, 3774], 'incubation': [3728], 'time': [3729], 'minimized': [3731], 'order': [3733], 'detect': [3735], 'associations': [3742], 'occur': [3744, 4613], 'after': [3745], 'lysis.': [3746], 'co-precipitated': [3753], 'GST-FKBP12': [3755], 'columns': [3756], 'precipitated': [3767], 'varied': [3769], 'accordance': [3771], 'C).': [3780, 4200, 4533], 'similarly': [3791], 'liver': [3793, 4587], '(data': [3795, 3853, 4328, 4368], 'shown).': [3797, 3855, 4330, 4370], 'addition,': [3799, 4242], 'experiment': [3801], 'revealed': [3802, 3943, 4269, 4419], 'apparent': [3810], 'mass': [3812, 3931], '230': [3814, 4275], 'kDa': [3815, 3934], '(more': [3816], 'details': [3817], 'below).': [3818], 'Utilizing': [3819, 3982], 'nucleotide': [3820], 'derived': [3822], 'sequence,': [3826], 'clones.': [3838], '5′-rapid': [3840], 'yielded': [3848], 'upstream': [3851], 'assembled': [3861], '7272': [3866], 'nucleotides.': [3867], 'starting': [3869], 'methionine': [3870], 'assigned': [3872], 'AUG': [3877, 3882], 'codon': [3878], '(nucleotide': [3879], '332).': [3880], 'preceded': [3884], 'stop': [3888], 'codons': [3889], 'exists': [3891], 'context': [3894], 'Kozak': [3897], 'initiation': [3899], 'consensus': [3900], '(51Kozak': [3901], 'Cell': [3904], '1989;': [3906], '108:': [3907], '229-241Crossref': [3908], '(2810)': [3911], '6.5-kilobase': [3915], 'codes': [3919], '2182': [3924], 'predicted': [3929, 4238, 4288], '243': [3933], '3).': [3936], 'search': [3938], 'data': [3941], 'bases': [3942], 'previously': [3949], 'characterized': [3950], 'different': [3964], 'truncating': [3968], '900-base': [3970], 'analysis': [3978, 4262], 'retain': [3996], 'studies': [4013, 4158, 4563], 'GST-Sepharose': [4023], 'These': [4028], 'analyses': [4029], 'indicate': [4030, 4362, 4993], 'can': [4040, 4220, 4254], 'ascribed': [4042], 'near': [4048], 'terminus': [4051], 'notable': [4058], 'calculated': [4062, 4113], 'pI': [4063], '10.3,': [4070], '5.7.': [4077], 'evaluate': [4079], '(His)6-cain.': [4096], 'inhibited': [4099], 'activityin': [4101], 'half-maximal': [4104], 'evident': [4106], 'about': [4108, 4687, 4709], '0.4–0.5': [4109], 'Ki': [4114, 4684], 'value': [4115, 4685, 4747], '0.44': [4117], 'Dixon': [4123], 'plot': [4124], 'indicates': [4125], 'investigate': [4135], 'possibility': [4137], 'our': [4156, 4237, 4784], 'varying': [4163], 'independent': [4177, 4946], 'concentration.': [4180], 'Even': [4181], '50-fold': [4187], 'increase': [4188], 'concentration,': [4191], 'curve': [4194], 'essentially': [4196], '7.5-kilobase': [4207], 'transcript': [4208, 4233], 'enriched': [4211, 4521], 'kidney,': [4214], 'testis': [4216], 'tissues': [4226, 4259], 'size': [4232], 'consistent': [4235, 4285], 'cDNA.': [4240], 'smaller': [4244, 4295], 'less': [4246], 'abundant': [4247], 'transcript,': [4248], 'possibly': [4249, 4305], 'alternative': [4252], 'splicing,': [4253], 'examined.': [4260], 'discrete': [4271], 'band': [4272, 4281], 'approximately': [4274], 'kDa.': [4276], 'mobility': [4278], 'weight': [4290], 'Several': [4294], 'immunoreactive': [4296], 'species': [4297], 'cerebellum': [4302], 'liver,': [4304], 'representing': [4306], 'tissue-specific': [4307], 'isoforms': [4308], 'proteolytic': [4310], 'fragments': [4311], 'bands': [4319], 'eliminated': [4321], 'pre-absorbing': [4323], 'Protein': [4331], 'matched': [4333], 'mRNA': [4336], 'levels': [4337], 'particularly': [4342], 'regard': [4344, 4715], 'low': [4347, 4433], 'skeletal': [4352], 'muscle': [4353], 'heart': [4355], 'Subcellular': [4359], 'fractionation': [4360, 4991], 'predominantly': [4366, 4505], 'cytosolic': [4367, 4999], 'share': [4374], 'similar': [4376, 4605], 'distribution': [4377], 'patterns': [4378, 5151], 'supporting': [4382, 4632], '(52Dawson': [4390, 4640], 'Lyons': [4394, 4644], 'W.E.': [4395, 4645], 'Blue': [4398, 4648], 'Neuroscience.': [4402, 4652], '62:': [4404, 4654], '569-580Crossref': [4405, 4655], '(127)': [4408, 4658], 'striking': [4421], 'similarity': [4422, 4622, 4667], '7': [4429, 4500, 4532], 'display': [4432], 'brainstem,': [4437], 'are': [4439, 4494, 4519, 4801, 5141], 'olfactory': [4443, 4448, 4483], 'bulb,': [4444], 'caudate,': [4445], 'nucleus': [4446], 'accumbens,': [4447], 'tubercle,': [4449], 'zona': [4450], 'reticulata': [4451], 'substantia': [4454], 'nigra,': [4455], 'layers': [4458], 'dentate': [4463], 'gyrus.': [4464], 'co-localization': [4466], 'transcripts': [4471], 'appears': [4472, 4691], 'greater': [4474, 4666], 'than': [4475, 4673], 'epithelium,': [4484], 'virtually': [4488], 'undetectable,': [4489], 'present': [4495, 4536], 'great': [4497], 'localized': [4504], 'cerebellar': [4507], 'Purkinje': [4508, 4529], 'granule': [4513, 4523], 'cells.': [4514], 'While': [4515], 'occurs': [4527, 4568], 'study': [4537], 'Multiple': [4552], 'reveal': [4564], 'bothin': [4569], 'vivo.': [4573], 'Perhaps': [4589], 'impressive': [4592], 'link': [4597], 'strikingly': [4604], 'localizations': [4606, 4624], 'exclusively': [4614], 'neurons.': [4616], 'Previously,': [4617], 'reported': [4619], 'FBKP12': [4628], 'physiological': [4634, 5170], 'relationship': [4635], 'Scholar).In': [4660], 'reveals': [4663], 'FKBP12.': [4678], '0.4': [4688], 'μm,': [4689], 'potent': [4696, 4712], 'inhibitor': [4699, 5166], 'AKAP79,': [4702, 5062, 5075], 'inhibitor,': [4707], 'itself': [4744, 5145], 'aKi': [4746], '10–50': [4749], 'Whether': [4769, 5130], 'action': [4772], 'exerted': [4776, 5142], 'CnB': [4780], 'unclear.': [4782], 'observe': [4787], 'CnB.': [4795], 'subunits': [4800], 'associated': [4804], 'unexpected': [4809], 'they': [4811], 'would': [4812, 5200], 'complex.': [4816], 'location(s)': [4822], 'FKBP12/FK506-binding': [4826], 'sites,': [4827], 'showed': [4831], 'sterically': [4847], 'blocks': [4848], 'access': [4849], 'substrate-binding': [4852], '(53Kissinger': [4860], 'C.R.': [4861], 'Parge': [4862], 'H.E.': [4863], 'Knighton': [4864], 'D.R.': [4865], 'Lewis': [4866], 'C.T.': [4867], 'Pelletier': [4868], 'L.A.': [4869], 'Tempczyk': [4870], 'Kalish': [4872], 'V.J.': [4873], 'Tucker': [4874], 'K.D.': [4875], 'Showalter': [4876], 'R.E.': [4877], 'Moomaw': [4878], 'E.W.': [4879], 'Gastinel': [4880], 'L.N.': [4881], 'Habuka': [4882], 'N.': [4883], 'Chen': [4884], 'Maldonado': [4886], 'F.': [4887], 'Barker': [4888], 'J.E.': [4889, 4893], 'Bacquet': [4890], 'Villafranca': [4892], '641-644Crossref': [4897], '(697)': [4900], '54Griffith': [4903], 'Kim': [4905, 4907], 'E.E.': [4908], 'Sintchak': [4909], 'M.D.': [4910], 'Thomson': [4911], 'Fitzgibbon': [4913], 'Fleming': [4915], 'Caron': [4917], 'P.R.': [4918], 'Hsiao': [4919], 'Navia': [4921], '82:': [4925], '507-522Abstract': [4926], '(772)': [4932], 'defines': [4944], 'shown': [4954], 'likely': [4960], 'calmodulin-binding': [4964], 'produced': [4973], 'alteration': [4975], "cain's": [4977], 'How': [4982], 'might': [4983, 5012, 5054], 'regulate': [4986], 'calcineurin?': [4987], 'Our': [4988], 'limited': [4989], 'subcellular': [4990], 'soluble,': [4998], 'translocate': [5005], 'cytoskeleton': [5008], 'loosely': [5014], 'bound.': [5015], 'attached': [5023, 5138], 'numerous': [5025], 'besides': [5027], 'Consistent': [5029], 'fact': [5034], 'restricted': [5041], 'small': [5044], 'area': [5045], 'One': [5053], 'conceptualize': [5055], 'functions': [5056], 'analogy': [5060], 'another': [5063], 'For': [5071], 'preponderance': [5082], 'basic': [5084], 'Conceivably,': [5124], 'kinases.': [5129], 'activities': [5135], 'clear,': [5148], 'yet': [5156], 'established.': [5158], 'provide': [5175, 5201], 'docking': [5177], 'inactive': [5183], 'form.': [5184], 'regard,': [5187], 'target': [5190], 'inactivated': [5191], 'specific': [5194, 5206], 'locations': [5196], 'thank': [5210, 5228], 'Jenny': [5211], 'Hong': [5212], 'Hyung': [5214], 'Chun': [5215], 'expert': [5217], 'technical': [5218], 'assistance': [5219], 'careful': [5221], 'manuscript.': [5225], 'Roxanne': [5229], 'Ashworth': [5230], 'sequencing': [5232], 'cDNA,': [5236, 5255], 'Noam': [5237], 'help': [5240], 'Western,': [5244], 'Claude': [5246], 'generous': [5250], 'CnAβ': [5254], 'David': [5264], 'members': [5267], 'laboratory': [5271], 'helpful': [5273], 'advice': [5274], 'insightful': [5276], 'discussions.': [5277]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2010605892', 'counts_by_year': [{'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-17T12:37:56.092633', 'created_date': '2016-06-24'}
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