Publication Information

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1939], 'fragment': [22, 181, 209, 368, 679, 776, 1097, 1112, 1149, 1756, 3243, 4102, 4109, 4163, 4171], 'maturation': [23, 182, 210, 369, 1098, 1113, 1150, 1757, 1862], 'during': [24, 135, 211, 322, 3936], 'lagging': [25, 212, 682, 947], 'strand': [26, 213, 667, 683, 705, 948], 'synthesis.': [27, 214, 611], 'In': [28, 115, 215, 302, 597, 805, 917, 1055, 1424, 1834, 1866, 4137, 4231, 4536], 'this': [29, 165, 216, 352, 651, 1333, 1867, 1974, 2963, 3646, 4398], 'report,': [30, 217, 4234], 'we': [31, 117, 167, 218, 304, 354, 1793, 1847, 1869, 1923, 3441, 3872, 4319, 4400], 'investigated': [32, 219], 'the': [33, 36, 53, 59, 71, 75, 85, 92, 100, 103, 107, 112, 120, 136, 142, 156, 160, 220, 223, 240, 246, 258, 262, 272, 279, 287, 290, 294, 299, 307, 323, 329, 343, 347, 528, 602, 616, 626, 629, 638, 663, 765, 779, 806, 815, 822, 828, 890, 894, 902, 910, 977, 985, 1064, 1124, 1140, 1157, 1168, 1226, 1649, 1661, 1671, 1684, 1688, 1697, 1724, 1734, 1742, 1759, 1839, 1861, 1880, 1888, 1936, 1945, 1970, 1985, 1991, 1994, 2052, 2066, 2070, 2081, 2083, 2097, 2107, 2116, 2138, 2152, 2155, 2187, 2192, 2196, 2203, 2208, 2220, 2232, 2268, 2278, 2281, 2325, 2328, 2354, 2365, 2369, 2385, 2389, 2403, 2413, 2415, 2418, 2425, 2539, 2542, 2545, 2548, 2557, 2571, 2577, 2652, 2698, 2701, 2728, 2737, 2740, 2779, 2794, 2845, 2848, 2858, 2862, 2873, 2884, 2892, 2938, 2946, 2953, 3000, 3204, 3241, 3310, 3389, 3629, 3654, 3670, 3737, 3764, 3767, 3777, 3780, 3790, 3793, 3821, 3860, 3868, 3875, 3895, 3898, 3905, 3915, 3930, 3941, 4016, 4021, 4037, 4045, 4104, 4111, 4120, 4128, 4139, 4147, 4151, 4161, 4165, 4169, 4173, 4194, 4202, 4209, 4232, 4235, 4251, 4327, 4341, 4356, 4362, 4365, 4402, 4406, 4449, 4457, 4465, 4485, 4494, 4512, 4517, 4529, 4578, 4582], 'properties': [34, 147, 221, 334], 'of': [35, 42, 79, 87, 94, 106, 122, 141, 222, 229, 266, 274, 281, 293, 309, 328, 403, 417, 628, 640, 665, 709, 717, 764, 809, 824, 893, 915, 1063, 1067, 1119, 1126, 1142, 1228, 1258, 1282, 1338, 1426, 1555, 1651, 1673, 1687, 1699, 1726, 1736, 1746, 1761, 1797, 1841, 1863, 1938, 1947, 1969, 1987, 2056, 2072, 2129, 2144, 2154, 2158, 2191, 2198, 2202, 2213, 2224, 2248, 2280, 2313, 2327, 2331, 2368, 2376, 2392, 2398, 2407, 2541, 2547, 2559, 2614, 2627, 2654, 2700, 2717, 2721, 2727, 2739, 2750, 2766, 2785, 2861, 2876, 2894, 2926, 2940, 2952, 3002, 3206, 3244, 3353, 3486, 3499, 3672, 3712, 3739, 3766, 3779, 3795, 3805, 3824, 3897, 3904, 3970, 4018, 4020, 4041, 4052, 4094, 4153, 4237, 4245, 4329, 4343, 4347, 4364, 4405, 4409, 4451, 4464, 4474, 4487, 4497, 4514, 4516, 4528, 4539, 4568, 4572, 4575], 'Dna2': [37, 54, 80, 150, 174, 224, 241, 267, 337, 361, 388, 1750, 1796, 1842, 1858, 1873, 1930, 2130, 2249, 2633, 2718, 2751, 3302, 3673, 4022, 4042, 4191, 4206, 4238, 4246, 4288, 4322, 4384, 4410], 'helicase/endonuclease': [38, 225], 'activities': [39, 226, 3641], 'search': [41, 228], 'their': [43, 230, 2530, 2596, 3884], 'vivo': [45, 232, 1744], 'physiological': [46, 233], 'functions': [47, 234], 'eukaryotes.': [49, 236], 'We': [50, 237, 4035, 4509], 'found': [51, 238, 4320], 'that': [52, 119, 149, 239, 306, 336, 534, 713, 719, 968, 975, 1095, 1133, 1664, 1681, 1795, 1872, 2298, 3445, 3510, 3653, 3940, 4092, 4190, 4205, 4253, 4321, 4383, 4417, 4511, 4527], 'helicase': [55, 242, 2217, 2719, 3674, 4023, 4033], 'activity': [56, 78, 243, 265, 773, 914, 974, 1805, 2247, 2553, 3823, 4024, 4047, 4262, 4336, 4386, 4408], 'translocates': [57, 244, 4192], '5′': [60, 247, 1062, 4195], 'to': [61, 154, 248, 341, 414, 509, 634, 646, 700, 723, 771, 817, 912, 945, 1116, 1123, 1433, 1837, 1855, 1877, 1965, 1982, 2012, 2095, 2195, 2257, 2290, 2447, 2638, 2988, 3193, 3388, 3481, 3514, 3668, 3718, 3751, 3802, 3819, 3893, 3910, 4014, 4054, 4115, 4124, 4196, 4201, 4389, 4564, 4577], '3′': [62, 249, 4197], 'direction': [63, 250, 4198, 4211], 'uses': [65, 252], 'DNA': [66, 96, 137, 253, 283, 324, 376, 404, 419, 425, 504, 537, 547, 610, 622, 649, 684, 704, 786, 793, 896, 920, 938, 981, 1188, 1286, 1600, 1674, 1689, 1788, 1845, 1949, 2255, 2272, 2394, 2723, 3247, 3252, 3261, 3665, 3869, 3879, 4038, 4090, 4132, 4415], 'free': [68, 255, 2254, 4393], 'ends': [69, 256, 2074, 2256, 4394, 4434, 4549], 'as': [70, 257, 647, 1998, 2076, 2089, 2174, 2236, 2251, 2347, 2464, 2629, 2659, 2709, 2802, 3319, 3357, 3423, 3589, 3678, 3828, 3912, 3927, 3929, 3947, 4010, 4395], 'preferred': [72, 259], 'substrate.': [73, 260, 2064, 2404, 4396], 'Furthermore,': [74, 261], 'endonucleolytic': [76, 263, 2054], 'cleavage': [77, 264, 2055, 2204, 2377, 2397, 2426, 2877, 2985, 3190, 4438, 4515, 4538, 4583], 'was': [81, 268, 966, 2124, 2554, 2636, 2657, 2692, 2761, 2935, 3290, 3317, 3383, 3409, 3503, 3574, 3656, 3723, 3746, 3787, 3908, 3918, 4239, 4247, 4323, 4476, 4499, 4522, 4550], 'markedly': [82, 269], 'stimulated': [83, 270, 4361], 'by': [84, 271, 659, 670, 909, 1703, 2151, 2207, 2261, 2324, 2334, 2501, 2570, 3726, 3749, 3797, 3889, 3920, 4027, 4043, 4085, 4411, 4428, 4520, 4544], 'presence': [86, 273, 2139, 2221, 2558, 2780, 2893, 3738, 3794, 3896, 4152, 4328], 'an': [88, 275, 1280, 1835, 2166, 3512, 3516], 'RNA': [89, 109, 126, 158, 276, 296, 313, 345, 378, 829, 892, 983, 1882, 1951], 'segment': [90, 110, 277, 297], 'at': [91, 278, 692, 901, 984, 1137, 1261, 1268, 2018, 2080, 2105, 2131, 2162, 2264, 2277, 2316, 2336, 2412, 2452, 2529, 2575, 2645, 2736, 2772, 2950, 3313, 3637, 3763, 3776, 3789, 4103, 4110, 4164, 4172, 4432, 4547], '5′-end': [93, 280, 3778, 3791, 4112, 4174], 'occurred': [98, 285], 'within': [99, 286], 'DNA,': [101, 288], 'ensuring': [102, 289], 'complete': [104, 291], 'removal': [105, 121, 292, 308], 'initiator': [108, 124, 295, 311, 891], 'on': [111, 129, 159, 298, 316, 346, 831, 1758, 1883, 1887, 2186, 2538, 2619, 2798, 4326], 'fragment.': [114, 162, 301, 349, 3741, 3769], 'addition,': [116, 303, 1056], 'demonstrated': [118, 305], 'pre-existing': [123, 310], '5′-terminal': [125, 312], 'segments': [127, 314, 830], 'depended': [128, 315], 'displacement': [131, 318], 'reaction': [132, 319, 2343, 2438, 2755, 3950, 4579], 'carried': [133, 320, 1849, 2229, 2693], 'out': [134, 321, 1850, 2694], 'polymerase': [138, 325, 374, 3248, 3253], 'δ-catalyzed': [139, 326], 'elongation': [140, 327], 'upstream': [143, 330], 'fragments.': [145, 332, 1748, 1865, 1885, 1940], 'These': [146, 333, 1092], 'indicate': [148, 335, 2284, 2364, 2374, 2544, 2744, 2844, 2999, 3203], 'is': [151, 338, 533, 601, 619, 906, 1114, 1134, 1196, 1656, 1660, 1677, 1694, 1874, 2704, 4387], 'well': [152, 339, 780, 1153, 1875, 3928], 'suited': [153, 340, 1876], 'remove': [155, 342, 1878], 'primer': [157, 344, 644, 648, 654, 895, 1881], 'Based': [163, 350, 1886], 'op': [164, 351], 'information,': [166, 353], 'propose': [168, 355, 1924], 'new': [170, 357, 3218], 'model': [171, 358, 808, 1927], 'plays': [175, 362, 1665, 1931], 'direct': [177, 364, 1556], 'role': [178, 365, 627, 1141, 1669, 1786, 1840, 1934], 'conjunction': [184, 371], 'Fen-1.': [186, 373, 916], 'circular': [380], 'replication': [381, 393, 405, 524, 548, 693, 810, 923, 931, 1287, 1789], 'protein-A': [382, 924], 'histidine': [383, 3307], 'Xpress-epitope': [385], 'tagged': [386], 'recombinant': [387, 3301, 3381, 4286], 'protein': [389, 2211, 3303, 4122], 'nucleotide': [390], 'double-strand': [391], 'break': [392], 'factor-C': [394, 932], 'proliferating': [395, 926], 'cell': [396, 927, 1235], 'nuclear': [397, 928], 'antigen': [398, 929], 'Biochemical': [399], 'genetic': [401, 1763, 1851, 1894], 'studies': [402, 1854, 1890, 1895], 'viruses': [407], 'lower': [409], 'eukaryotes': [410, 550], 'have': [411, 1848], 'contributed': [412], 'substantially': [413], 'our': [415], 'understanding': [416], 'eukaryotic': [418, 503, 523, 617, 766], 'synthesis': [420, 505, 639, 668, 680], '(1Kornberg': [421, 789], 'A.': [422, 790, 837, 1083, 1216, 1471, 1615, 4222, 4273], 'Baker': [423, 791], 'T.A.': [424, 580, 792], 'Replication.': [426, 794], '2nd': [427, 795], 'Ed.': [428, 796], 'W.': [429, 797, 1209, 1319, 1351], 'H.': [430, 798], 'Freeman': [431, 799], '&': [432, 800], 'Co.,': [433, 801], 'New': [434, 802, 3237], 'York1992Google': [435, 803], 'Scholar,': [436, 449, 469, 483, 565, 578, 739, 853, 873, 1009, 1023, 1043, 1313, 1361, 1378, 1393, 1469, 1483, 1505, 1527, 3463], '2Challberg': [437], 'M.D.': [438], 'Kelly': [439], 'T.J.': [440], 'Annu.': [441, 488, 555, 568, 729], 'Rev.': [442, 489, 556, 569, 730], 'Biochem.': [443, 490, 557, 570, 731], '1989;': [444, 3430], '58:': [445], '671-717Crossref': [446], 'PubMed': [447, 467, 479, 494, 561, 574, 592, 735, 757, 851, 871, 882, 959, 1005, 1019, 1041, 1050, 1087, 1220, 1248, 1309, 1327, 1359, 1374, 1389, 1411, 1465, 1479, 1501, 1523, 1549, 1575, 1594, 1619, 1641, 1718, 1779, 1829, 1920, 2490, 2685, 2827, 2919, 3285, 3345, 3375, 3403, 3433, 3459, 3476, 3533, 3549, 3566, 3603, 3702, 3854, 3995, 4079, 4226, 4277, 4313], 'Google': [448, 468, 482, 497, 564, 577, 595, 738, 760, 852, 872, 885, 962, 1008, 1022, 1042, 1053, 1090, 1223, 1251, 1312, 1328, 1360, 1377, 1392, 1414, 1468, 1482, 1504, 1526, 1552, 1578, 1597, 1622, 1644, 1721, 1782, 1832, 1921, 2493, 2688, 2830, 2922, 3288, 3348, 3378, 3406, 3436, 3462, 3479, 3536, 3552, 3569, 3606, 3705, 3857, 3998, 4082, 4229, 4280, 4316], '3Hurwitz': [450], 'J.': [451, 458, 746, 841, 842, 862, 994, 1015, 1032, 1298, 1322, 1354, 1454, 1475, 1490, 1512, 1538, 1772, 1818, 2479, 2674, 2816, 2908, 3273, 3274, 3296, 3334, 3470, 3527, 3597, 3691, 3843, 3984, 4068, 4215, 4266], 'Dean': [452], 'F.B.': [453], 'Kwong': [454], 'A.D.': [455], 'Lee': [456, 1810, 1814, 1904, 2471, 2475, 2666, 2670, 2808, 2812, 2900, 2904, 3326, 3330, 3685, 3687, 3835, 3839, 3976, 3980, 4060, 4064], 'S.H.': [457, 857, 1807, 1815, 1903, 2468, 2476, 2663, 2671, 2805, 2813, 2897, 2905, 3323, 3331, 3686, 3832, 3840, 3973, 3981, 4057, 4065, 4294], 'Biol.': [459, 747, 843, 863, 995, 1033, 1299, 1385, 1455, 1491, 1513, 1539, 1775, 1819, 2480, 2675, 2817, 2909, 3275, 3335, 3371, 3399, 3455, 3471, 3528, 3545, 3562, 3598, 3692, 3844, 3985, 4069], 'Chem.': [460, 748, 844, 864, 996, 1034, 1300, 1456, 1492, 1514, 1540, 1820, 2481, 2676, 2818, 2910, 3276, 3336, 3472, 3529, 3599, 3693, 3845, 3986, 4070], '1990;': [461, 865], '265:': [462, 866], '18043-18046Abstract': [463], 'Full': [464, 476, 587, 589, 752, 754, 848, 868, 1000, 1002, 1038, 1304, 1306, 1406, 1408, 1460, 1462, 1496, 1498, 1518, 1520, 1544, 1546, 1570, 1572, 1636, 1638, 1715, 1824, 1826, 2485, 2487, 2680, 2682, 2822, 2824, 2914, 2916, 3280, 3282, 3340, 3342, 3697, 3699, 3849, 3851, 3990, 3992, 4074, 4076], 'Text': [465, 477, 588, 590, 753, 755, 849, 869, 1001, 1003, 1039, 1305, 1307, 1407, 1409, 1461, 1463, 1497, 1499, 1519, 1521, 1545, 1547, 1571, 1573, 1637, 1639, 1716, 1825, 1827, 2486, 2488, 2681, 2683, 2823, 2825, 2915, 2917, 3281, 3283, 3341, 3343, 3698, 3700, 3850, 3852, 3991, 3993, 4075, 4077], 'PDF': [466, 478, 591, 756, 850, 870, 1004, 1040, 1308, 1410, 1464, 1500, 1522, 1548, 1574, 1640, 1717, 1828, 2489, 2684, 2826, 2918, 3284, 3344, 3701, 3853, 3994, 4078], '4Stillman': [470], 'B.': [471, 487, 554, 728, 877, 954, 1293, 1447, 2178, 3396, 3428, 3452, 3542, 3559], 'Cell.': [472, 583, 1384, 1402, 1566, 1632, 1711, 1774, 3370, 3398, 3454, 3544, 3561], '1994;': [473, 879, 956, 1016, 1035], '78:': [474], '725-728Abstract': [475], 'Scopus': [480, 495, 562, 575, 593, 736, 758, 883, 960, 1006, 1020, 1051, 1088, 1221, 1249, 1310, 1375, 1390, 1412, 1466, 1480, 1502, 1524, 1550, 1576, 1595, 1620, 1642, 1719, 1780, 1830, 2491, 2686, 2828, 2920, 3286, 3346, 3376, 3404, 3434, 3460, 3477, 3534, 3550, 3567, 3604, 3703, 3855, 3996, 4080, 4227, 4278, 4314], '(222)': [481], '5Waga': [484], 'S.': [485, 552, 726, 875, 952, 1082, 1215, 1295, 1369, 1453, 1487, 1509, 1614, 1798, 3265, 3354, 4221, 4272], 'Stillman': [486, 553, 727, 876, 953, 3395, 3427, 3451, 3541, 3558], '1998;': [491, 558, 584, 732, 1084, 1217, 1245, 1493, 1515, 1591, 1821, 2482, 2677, 2819, 2911, 3337, 3846, 3987, 4071], '67:': [492, 559, 733], '721-751Crossref': [493, 560, 734], '(660)': [496, 563, 737, 1481], 'Scholar).': [498, 596, 761, 804, 886, 963, 1054, 1091, 1252, 1329, 1722, 1833, 2494, 2689, 2831, 2923, 3349, 3407, 3437, 3570, 3607, 4230, 4281], 'various': [500, 1948, 3814], 'steps': [501, 3509], 'are': [506, 544, 656, 695, 941, 1185, 1192, 1976, 1997, 2078, 2275, 2294, 2299, 2410, 2734, 2948], 'basically': [507], 'similar': [508], 'those': [510], 'prokaryotes,': [512], 'requiring': [513, 4558], 'many': [514], 'common': [515], 'enzymatic': [516, 711], 'functions.': [517], 'Despite': [518], 'these': [519, 1427], 'striking': [520], 'similarities,': [521], 'certain': [522], 'components': [525], 'differ': [526], 'from': [527, 1683, 2028, 2045, 2396, 3236, 3255, 3294, 3411, 3495, 3518, 3628, 4127], 'prokaryotic': [529, 614, 782], 'counterparts.': [530], 'Most': [531], 'noteworthy': [532], 'three': [535, 2269, 4413], 'essential': [536, 1186], 'polymerases': [538, 767], '(pol)1': [539], 'α,': [540], 'δ,': [541, 922], 'ε': [543, 675], 'required': [545, 1695, 4255], 'for': [546, 662, 676, 681, 774, 1167, 1187, 1266, 1696, 1733, 1741, 1944, 2134, 2165, 2319, 2339, 2442, 2449, 2595, 2621, 2648, 2775, 4260, 4333, 4448], '(5Waga': [551, 725], '6Wang': [566], 'T.S.': [567], '1991;': [571], '60:': [572], '513-552Crossref': [573], '(451)': [576], '7Baker': [579], 'Bell': [581], 'S.P.': [582], '92:': [585, 4224, 4275], '295-305Abstract': [586], '(274)': [594], 'contrast,': [598, 4138, 4537], 'pol': [599, 623, 630, 660, 671, 674, 787, 921, 3262], 'III': [600], 'only': [603, 1662, 2890, 3762, 3775], 'replicative': [604], 'enzyme': [605, 1199, 1663, 4140, 4455, 4498, 4561], 'prokaryotes': [607], 'involved': [608], 'Unlike': [612], 'its': [613, 1229, 1418, 1762, 1784, 2252, 3314, 4028, 4116, 4334], 'counterpart,': [615], 'primase': [618], 'complexed': [620], 'α.': [624], 'Thus,': [625, 1723], 'α-primase': [631], 'complex': [632, 710, 1104], 'appears': [633], 'function': [635], 'solely': [636], 'short': [642, 687], 'RNA-DNA': [643, 903], '(referred': [645], 'paper).': [652], 'DNAs': [655], 'then': [657, 698, 2172, 2632, 3730, 3747, 3809], 'utilized': [658], 'δ': [661, 672, 3263], 'initiation': [664], 'leading': [666], 'or': [673, 982, 1172, 1580, 2059, 2109, 2115, 2141, 2382, 2564, 2581, 2769, 2782, 4422, 4425], 'each': [677, 2001, 2292, 2314, 2615, 2639, 3003, 3207], 'replication.': [685, 1675], 'discontinuous': [689], 'fragments': [691, 833, 1701], 'forks': [694], 'processed': [696, 1702], 'joined': [699], 'generate': [701, 3752], 'continuous': [703], 'through': [706, 1101, 2455, 4048], 'series': [708], 'reactions': [712, 2227, 2790], 'require': [714, 1117], 'number': [716], 'enzymes': [718], 'include': [720], '5′-': [722, 770, 816, 911, 2058, 2108, 2381, 2578, 4421], '3′-exonuclease': [724, 772, 818, 913], '8Bambara': [740], 'R.A.': [741, 989, 1031, 1076, 1451, 1489], 'Murante': [742, 990], 'R.S.': [743, 991, 1025, 1072], 'Hendericksen': [744, 992, 1073], 'L.A.': [745, 993, 1074], '1997;': [749, 997, 1047, 1403, 1476, 1567, 1776, 3473, 3530, 3600, 3694], '272:': [750, 998, 3474, 3531, 3601, 3695], '4647-4650Abstract': [751, 999], '(298)': [759, 1007], 'However,': [762], 'none': [763], 'possess': [768], 'intrinsic': [769, 4029], 'processing,': [777], 'unlike': [778, 1180], 'characterized': [781], 'polymerase,': [783], 'Escherichia': [784], 'coli': [785, 3246], 'I': [788, 940, 1691], 'current': [807], 'eukaryotes,': [812], 'Fen-1': [813, 969, 1127, 1143, 1170, 1429, 1730, 3890, 3911, 3921], 'provides': [814], 'assistance': [823], 'RNase': [825, 887, 934, 1058, 1129, 1145, 1173, 1194], 'HI': [826, 888, 1059, 1146, 1174, 1195], 'removes': [827], '(9Ishimi': [834], 'Y.': [835, 1511, 1537], 'Claude': [836], 'Bullock': [838], 'P.': [839, 1201, 1238], 'Hurwitz': [840, 3272, 3297], '1988;': [845], '263:': [846], '19723-19733Abstract': [847], '10Goulian': [854], 'M.': [855], 'Richards': [856], 'Heard': [858], 'C.J.': [859], 'Bigsby': [860], 'B.M.': [861], '18461-18471Abstract': [867], '11Waga': [874], 'Nature.': [878, 955, 3429], '369:': [880, 957], '207-212Crossref': [881, 958], '(496)': [884, 961], 'hydrolyzes': [889], 'leaving': [897], 'single': [899], 'ribonucleotide': [900, 1066], 'junction,': [904], 'subsequently': [907], 'removed': [908], 'mammalian': [918, 1057], 'cells,': [919], '(RPA),': [925], '(PCNA),': [930], '(RFC),': [933], 'HI,': [935, 1130, 1705], 'ligase': [939, 1690], 'necessary': [942], 'sufficient': [944], 'reconstitute': [946], 'synthesisin': [949], 'vitro': [950], '(11Waga': [951], 'Recently,': [964, 1792], 'it': [965, 4254, 4360], 'shown': [967, 1432, 2079, 2185, 2276, 2537, 2705, 2735], 'cleaves': [976], '5′-unannealed': [978], '(ss)': [980], 'duplex': [986, 2271, 2393, 2722, 2732, 3744, 3816, 4089, 4131, 4144], 'junction': [987], '(8Bambara': [988], '12Harrington': [1010], 'J.J.': [1011, 1029], 'Lieber': [1012, 1607], 'M.R.': [1013, 1045, 1608], 'EMBO': [1014, 1474], '13:': [1017], '1235-1246Crossref': [1018], '(372)': [1021], '13Murante': [1024], 'Huang': [1026], 'L.': [1027, 1297, 1367], 'Turchi': [1028], 'Bambara': [1030, 1075, 1450, 1488], '269:': [1036, 1372], '1191-1196Abstract': [1037], '14Lieber': [1044], 'BioEssays.': [1046], '19:': [1048], '233-240Crossref': [1049], '(395)': [1052], 'can': [1060], 'cleave': [1061], 'last': [1065], 'ssRNA-DNA': [1068], 'hybrid': [1069], 'molecules': [1070], '(15Murante': [1071], 'Proc.': [1077, 1210, 1609, 4216, 4267], 'Natl.': [1078, 1211, 1610, 4217, 4268], 'Acad.': [1079, 1212, 1611, 4218, 4269], 'Sci.': [1080, 1213, 1612, 4219, 4270], 'U.': [1081, 1205, 1214, 1242, 1613, 4220, 4271], '95:': [1085, 1218], '2244-2249Crossref': [1086], '(65)': [1089, 1467], 'findings': [1093], 'suggest': [1094], 'could': [1099], 'occur': [1100], 'more': [1103, 1738, 3657], 'process': [1105, 1132], 'than': [1106, 3658, 4526], 'inferred': [1107, 4248], 'previously.': [1108], 'For': [1109, 3438, 4397], 'example,': [1110], 'likely': [1115, 4388], 'formation': [1118], '5′-tail': [1121, 3903, 4466, 4518], 'prior': [1122, 1964], 'action': [1125], 'and/or': [1128, 4006], 'poorly': [1135], 'understood': [1136], 'present.': [1138], 'Although': [1139, 1749, 4340], 'has': [1151, 1430, 1751], 'been': [1152, 1431, 1752], 'established': [1154], 'vitro,': [1156], 'phenotypes': [1158], 'observed': [1159], 'strains': [1163, 1254], 'lacking': [1164, 1729], 'gene': [1166, 1626, 3352], 'yeast': [1169, 1273, 1653, 1685, 1727, 1844, 3414], '(yFen-1)': [1171], '(RAD27/RTH1': [1175], 'orRNH35,': [1176], 'respectively)': [1177], 'reveal': [1178], 'that,': [1179], 'other': [1181], 'genes': [1182], 'whose': [1183], 'products': [1184, 2170, 2205, 2233, 2344, 2378, 2427, 2439, 2795, 4439], 'replication,': [1189, 1846], 'RAD27': [1190], 'andRNH35': [1191], 'dispensable.': [1193], 'two-subunit': [1198], '(16Frank': [1200], 'Braunshofer-Reiter': [1202, 1239], 'C.': [1203, 1240, 1317, 1349, 1911, 3688], 'Wintersberger': [1204, 1241], 'Grimm': [1206], 'R.': [1207, 1529, 3360], 'Büsen': [1208], '12872-12877Crossref': [1219], '(68)': [1222], 'Scholar),': [1224, 1415, 1553, 1598, 1623, 1783, 1922, 3379, 3537, 3553, 4317], 'deletion': [1227, 1257, 1682], 'catalytic': [1230], 'subunit': [1231], 'did': [1232], 'not': [1233, 3662, 3923, 4135, 4168, 4240, 4324, 4338], 'affect': [1234], 'viability': [1236, 1650, 1725], '(17Frank': [1237], 'FEBS': [1243], 'Lett.': [1244], '421:': [1246], '23-26Crossref': [1247], '(44)': [1250], 'Yeast': [1253], 'carrying': [1255], 'RAD27are': [1259], 'viable': [1260], '30': [1262, 1331], '°C': [1263, 2133, 2164, 2318, 2338, 2647, 2774], 'compromised': [1265], 'growth': [1267], '37': [1269, 2132, 2163, 2317, 2337, 2646, 2773], '°C,': [1270, 1332], 'producing': [1271], 'strain': [1274, 1334, 1655, 3415], 'terminally': [1277], 'arrested': [1278], 'phenotype,': [1279], 'indication': [1281], 'defect': [1284], '(18Sommers': [1288], 'C.H.': [1289, 1585], 'Miller': [1290], 'E.J.': [1291], 'Dujon': [1292], 'Prakash': [1294, 1296, 1366, 1368], '1995;': [1301, 1324, 1356, 1371, 1386, 3372, 4223, 4274], '270:': [1302], '4193-4196Abstract': [1303], '(162)': [1311], '19Reagan': [1314], 'M.S.': [1315, 1347, 1445, 1449, 1485, 1535], 'Pittinger': [1316, 1348], 'Siede': [1318, 1350], 'Friedberg': [1320, 1352], 'E.C.': [1321, 1353], 'Bacteriol.': [1323, 1355], '177:': [1325, 1357], '364-371Crossref': [1326, 1358], 'At': [1330], 'shows': [1335], 'elevated': [1336], 'rates': [1337], 'spontaneous': [1339], 'mutation,': [1340], 'mitotic': [1341, 1625], 'recombination,': [1342], 'chromosome': [1344, 1422], 'loss': [1345], '(19Reagan': [1346], '20Johnson': [1362], 'R.E.': [1363], 'Kovvali': [1364], 'G.K.': [1365], 'Science.': [1370, 1590], '238-240Crossref': [1373], '(194)': [1376], '21Vallen': [1379], 'E.A.': [1380], 'Cross': [1381], 'F.R.': [1382], 'Mol.': [1383, 1773, 3369, 3397, 3453, 3543, 3560], '15:': [1387, 3373], '4291-4302Crossref': [1388], '(95)': [1391], '22Tishkoff': [1394], 'D.X.': [1395, 1559], 'Filosi': [1396, 1560], 'N.': [1397, 1561], 'Gaida': [1398, 1562], 'G.M.': [1399, 1563], 'Kolodner': [1400, 1564], 'R.D.': [1401, 1565], '88:': [1404, 1568], '253-263Abstract': [1405, 1569], '(394)': [1413, 1577], 'consistent': [1416], 'critical': [1419, 1739], 'roles': [1420], 'maintenance.': [1423], 'support': [1425], 'findings,': [1428], 'participate': [1434], 'long': [1436], 'patch': [1437], 'base': [1438], 'excision': [1439], 'repair': [1440], 'human': [1442], 'cells': [1443, 1707, 1728], '(23DeMott': [1444], 'Shen': [1446], 'Park': [1448, 1534, 1812, 1910, 2473, 2668, 2810, 2902, 3328, 3837, 3978, 4062], 'Zigman': [1452, 1486], '1996;': [1457], '271:': [1458], '30068-30076Abstract': [1459], '24Klungland': [1470], 'Lindahl': [1472], 'T.': [1473], '16:': [1477], '3341-3348Crossref': [1478], '25DeMott': [1484], '273:': [1494, 1516, 1822, 2483, 2678, 2820, 2912, 3338, 3847, 3988, 4072], '27492-27498Abstract': [1495], '(80)': [1503], '26Kim': [1506], 'K.': [1507, 1531, 3394, 3450, 3540, 3557], 'Biade': [1508], 'Matsumoto': [1510, 1536], '8842-8848Abstract': [1517], '(188)': [1525], '27Gary': [1528], 'Kim': [1530, 1908, 4291, 4295, 4301], 'Cornelius': [1532], 'H.L.': [1533], '1999;': [1541, 1616, 1633], '274:': [1542], '4354-4363Abstract': [1543], '(149)': [1551], 'maintenance': [1554], 'repeats': [1557, 1583], '(22Tishkoff': [1558], 'Scholar)': [1579, 1645, 3289, 3480, 3706, 3858, 3999, 4083], 'CTG': [1581], 'trinucleotide': [1582], '(28Freudenreich': [1584], 'Kantrow': [1586], 'S.M.': [1587], 'Zakian': [1588], 'V.A.': [1589], '279:': [1592], '853-856Crossref': [1593], '(362)': [1596], 'nonhomologous': [1599], 'end': [1601], 'joining': [1602, 1698], '(29Wu': [1603], 'X.': [1604], 'Wilson': [1605], 'T.E.': [1606], '96:': [1617, 1634], '1303-1308Crossref': [1618], '(148)': [1621], 'conversion': [1627], '(30Holmes': [1628], 'A.M.': [1629], 'Haber': [1630], 'J.E.': [1631], '415-424Abstract': [1635], '(218)': [1643], 'yeasts.': [1647], 'Therefore,': [1648], 'theRAD27-deleted': [1652], 'mutant': [1654, 2209], 'puzzling': [1657], 'if': [1658], 'yFen-1': [1659, 1768], 'such': [1666], 'crucial': [1668], 'completion': [1672], 'This': [1676, 3756, 3925, 4187, 4380], 'especially': [1678], 'true': [1679], 'considering': [1680], 'genome': [1686], 'gene,': [1692], 'Fen-1/RNase': [1704], 'renders': [1706], 'inviable': [1708], '(31Nasmyth': [1709], 'K.A.': [1710, 4302], '1977;': [1712], '12:': [1713, 3401, 3457, 3547, 3564], '1109-1120Abstract': [1714], '(75)': [1720], 'argues': [1731], 'strongly': [1732], 'existence': [1735], 'pathway': [1740], 'processing': [1745, 1937], 'basis': [1760], 'physical': [1765], 'interaction': [1766], '(32Budd': [1769], 'M.E.': [1770, 4213, 4264], 'Campbell': [1771, 4214, 4265], '17:': [1777], '2136-2142Crossref': [1778], '(193)': [1781], 'precise': [1785, 4452], 'remains': [1790], 'unclear.': [1791], 'reported': [1794], 'potent': [1802], 'ssDNA-specific': [1803, 4357], '(33Bae': [1806, 2467, 2662, 2804, 2896, 3322, 3831, 3972, 4056], 'Choi': [1808, 1900, 2469, 2664, 2806, 2898, 3324, 3683, 3833, 3974, 4058], 'E.': [1809, 1901, 2470, 2665, 2807, 2899, 3245, 3325, 3684, 3834, 3975, 4059], 'K.H.': [1811, 1905, 2472, 2667, 2809, 2901, 3327, 3836, 3977, 4061, 4290, 4298], 'J.S.': [1813, 2474, 2669, 2811, 2903, 3329, 3682, 3838, 3979, 4063], 'Seo': [1816, 1914, 2477, 2672, 2814, 2906, 3332, 3689, 3841, 3982, 4066, 4305], 'Y.S.': [1817, 1915, 2478, 2673, 2815, 2907, 3333, 3690, 3842, 3983, 4067, 4306], '26880-26890Abstract': [1823, 2484, 2679, 2821, 2913, 3339, 3848, 3989, 4073], '(115)': [1831, 2492, 2687, 2829, 2921, 3347, 3856, 3997, 4081], 'attempt': [1836], 'define': [1838], 'biochemical': [1853, 1889], 'examine': [1856], 'whether': [1857, 3874], 'participated': [1859], 'paper,': [1868], 'present': [1870], 'evidence': [1871], 'completely': [1879], 'presented': [1891, 2949], 'here': [1892], 'published': [1896], 'elsewhere': [1897], '(34Kang': [1898], 'H.Y.': [1899], 'Bae': [1902, 4293], 'Gim': [1906], 'B.S.': [1907], 'H.D.': [1909], 'MacNeill': [1912], 'S.A.': [1913], 'Genetics.': [1916], '2000;': [1917, 3277, 4310], '155:': [1918], '1055-1067Crossref': [1919], 'novel': [1926], 'key': [1933], 'All': [1941], 'oligonucleotides': [1942, 2004, 2086, 2288, 2521, 2586, 2850, 3862], 'used': [1943, 1972, 1981, 2087, 2274, 2289, 2587, 2961, 2987, 3192, 3667, 3818], 'construction': [1946], 'substrates': [1952, 2068, 2098, 2273, 2733, 3666, 3817, 3870, 3880, 3942, 4416], 'were': [1953, 2010, 2026, 2043, 2149, 2171, 2228, 2234, 2308, 2345, 2429, 2440, 2588, 2617, 2643, 2791, 2796, 2888, 3223, 3235, 3254, 3446, 3493, 3610, 3633, 3642, 3676, 3826, 3887, 4008, 4025, 4440], 'synthesized': [1954], 'commercially': [1955], '(Life': [1956], 'Technologies,': [1957], 'Inc.,': [1958], 'Gemini': [1960], 'Biotech)': [1961, 2528], 'gel-purified': [1963], 'use.': [1966], 'sequences': [1968], 'oligonucleotide': [1971, 2561, 2565, 2616, 2864, 3713, 3783], 'study': [1975], 'listed': [1977, 2300, 3863], 'TableI.': [1979], 'Oligonucleotides': [1980], 'prepare': [1983, 2989, 3194, 3771], 'substrates,': [1984, 1992], 'position': [1986, 2071, 2391, 2860, 2875], 'radioisotopic': [1988], 'labels': [1989], 'substrate': [1995, 2120, 2253, 2293, 2315, 2355, 2359, 2408, 2771, 2836, 2840, 2927, 3760, 3773, 3907, 3917, 3971, 4091, 4133, 4149, 4259, 4403, 4469, 4491, 4519], 'structures': [1996, 2726], 'described': [1999, 2175, 2237, 2420, 2465, 2660, 2803, 3320, 3358, 3391, 3424, 3447, 3590, 3679, 3829], 'figure.': [2002, 2084, 2282, 2416, 2741], '2': [2005, 2145, 2168, 2340, 2786, 3960, 4372, 4480, 4505, 4554], '12': [2007, 2512], '(Table': [2008], 'I)': [2009, 2094], 'complementary': [2011], 'φX174': [2013, 2730, 2992, 3197, 3719, 3754, 3806, 4096], 'sscDNA': [2014, 3720], '(New': [2015], 'England': [2016, 3238], 'Biolabs)': [2017], 'nucleotides': [2019], '702–753': [2020], '980–1006,': [2022], 'respectively.': [2023, 2361, 2842], 'Nucleoside': [2024], 'triphosphates': [2025], 'obtained': [2027, 3224, 3627], 'Roche': [2029, 3256], 'Molecular': [2030, 3257], 'Biochemicals': [2031], '[γ-32P]ATP': [2033, 3796], '(>5000': [2034, 2037], 'Ci/mmol),': [2035, 2038], '[α-32P]ddATP': [2036], '[α-32P]dCTP': [2040, 3728], '(>6000': [2041], 'Ci/mmol)': [2042], 'purchased': [2044], 'Amersham': [2046, 2526], 'Pharmacia': [2047, 2527, 3620], 'Biotech.Figure': [2048], '3ATP': [2049], 'differentially': [2050], 'influences': [2051], 'Dna2-mediated': [2053], 'unannealed': [2057], '3′-overhangs': [2060], 'Y-structured': [2063, 2067], 'A,': [2065, 2267, 4481, 4506, 4555], '32P-labeled': [2073, 2285, 2745], '(denoted': [2075], 'asterisks)': [2077], 'topof': [2082], '(indicated': [2088, 2569], 'circled': [2090], 'numbers,': [2091], 'see': [2092], 'Table': [2093, 2302, 2867, 3865], 'construct': [2096, 2291], 'contain': [2099], '25-nt': [2101], 'oligo(dT)': [2102, 2505], '((dT)25)': [2103], 'homopolymer': [2104], 'either': [2106, 2380, 2576, 2767, 4419], '3′-end.': [2110], '5′-end-labeled': [2112, 2770], '(lanes': [2113, 2118], '1–7)': [2114], '3′-end-labeled': [2117], '8–14)': [2119], '(15': [2121], 'fmol': [2122, 2312, 2765, 3969, 4478], 'each)': [2123], 'preincubated': [2125, 2309, 2618], '0.5': [2127, 4472], 'ng': [2128, 4473, 4574], '5': [2135, 2320, 4179, 4377, 4534], 'min': [2136, 2321, 2444, 2623, 2777], '(+)': [2140, 2781], 'absence': [2142, 2223, 2783], '(−)': [2143, 2784], 'mm': [2146, 2604, 2759, 2787, 3956], 'ATP.': [2147, 2225, 2788], 'Reactions': [2148], 'initiated': [2150, 2323], 'addition': [2153, 2326, 4342, 4571], 'indicated': [2156, 2295, 2329, 2411, 2748], 'amount': [2157, 2653, 2749, 2925, 4463, 4486, 4496], 'MgCl2': [2159, 2760], 'incubated': [2161, 2644, 2762], 'additional': [2167], 'min;': [2169], 'analyzed': [2173, 2235, 2346, 2430, 2797, 4442], 'Fig.2': [2177], 'M': [2179, 2495], 'denotes': [2180, 2388, 2496, 2520, 2872], 'molecular': [2181, 2497], 'size': [2182, 2197, 2498, 2516, 2546, 2591], 'markers.': [2183, 2199, 2549], 'Thenumbers': [2184, 2536], 'left': [2188, 2540], 'right': [2190], 'figure': [2193, 2543], 'refer': [2194], 'B,': [2200, 2417], 'analysis': [2201], 'generated': [2206], 'Dna2K1080E': [2210], '(devoid': [2212], 'both': [2214, 2265, 4433, 4548], 'ATPase': [2215, 2552], 'activities)': [2218], 'out,': [2230], 'A.View': [2239], 'Large': [2240, 2711, 2955], 'Image': [2241, 2712, 2956], 'Figure': [2242, 2713, 2957], 'ViewerDownload': [2243, 2714, 2958], '(PPT)Figure': [2244, 2715], '2The': [2245], 'prefers': [2250], 'internal': [2258, 2399, 4540], 'ssDNA': [2259, 2400, 3885, 4097, 4126, 4391, 4426, 4541], 'flanked': [2260, 4427, 4543], 'partial': [2262, 2270, 2731, 3743, 3815, 4088, 4429, 4545], 'duplexes': [2263, 4546], 'ends.': [2266, 2286, 2746], 'top': [2279, 2738], 'Theasterisks': [2283], 'ascircled': [2296], 'numbers': [2297, 2996, 3200], 'I.': [2303, 3866], 'Reaction': [2304, 2599], 'mixtures': [2305, 2600, 2642, 3951], '(20': [2306, 3952], 'μl)': [2307, 3953], '15': [2311, 2622, 2764, 3968], 'amounts': [2330, 2406, 2626, 4567], 'followed': [2333], 'incubation': [2335], 'min.': [2341], 'Fig.': [2349], '1.': [2350], 'S': [2351, 2832, 3617, 3631], 'andB': [2352], 'denote': [2353, 2835], 'alone': [2356, 2837], 'boiled': [2358, 2441, 2839], 'controls,': [2360, 2841], 'arrows': [2363], 'migration': [2366, 2390, 2859, 2874], 'positions': [2367, 2375, 2846], 'labeled': [2370, 2849, 3725, 3761, 3774, 3788, 3882], 'oligonucleotides.': [2371], 'Closed': [2372], 'arrowheads': [2373], 'containing': [2379, 2602, 2757, 2883, 4098], '3′-end': [2383, 2582, 2885, 2930, 3711, 3765, 4105, 4166, 4366], 'labels;': [2384], 'open': [2386, 2856], 'arrowhead': [2387, 2871], 'resulting': [2395], 'region': [2401, 3745, 4145], 'cleaved': [2409, 3748, 3888, 3919, 4470, 4492], 'bottomof': [2414], 'experiment': [2419, 2691], 'Awas': [2422], 'repeated,': [2423], 'but': [2424, 4167], 'formed': [2428, 2889], 'using': [2431, 3505, 3614, 3859, 4049, 4086, 4283, 4412, 4443], 'high': [2433, 4050], 'resolution': [2434, 4446], 'sequencing': [2435], 'gel.': [2436], '1': [2443, 2612, 2758, 2865, 3714, 3784], 'subjected': [2446], 'electrophoresis': [2448, 3938], '1.5': [2450], 'h': [2451], '35': [2453], 'watts': [2454], '20%': [2457], 'denaturing': [2458], 'polyacrylamide': [2459, 2800], 'gel': [2460, 2801, 3937, 4447], '(7': [2461], 'm': [2462], 'urea)': [2463], 'previously': [2466, 2661, 3321, 3392, 3448, 3680, 3830], 'markers': [2499, 2517], 'prepared': [2500, 3318, 3494, 3827], 'labeling': [2502], 'synthetic': [2504, 3861], 'mixture': [2506, 2756], '(2–4,': [2507], '6,': [2508], '8,': [2509], '10,': [2510], 'nt)': [2513, 4468, 4490], 'commercial': [2515], '((dGATC)n,': [2518], 'wheren': [2519], '8–32': [2522], 'nt': [2523, 2880], 'length,': [2525, 2882], '5′-ends': [2531], 'T4': [2533, 3229, 3251, 3798], 'polynucleotide': [2534, 3230, 3799], 'kinase.': [2535], 'C,': [2550], 'ssDNA-dependent': [2551], 'measured': [2555, 2658, 2936], 'unmodified': [2560], '(open': [2562, 2579], 'squares)': [2563], 'modified': [2566, 2597], 'biotin': [2568], 'capital': [2572], 'letter': [2573], 'B)': [2574], 'circles)': [2580], '(closed': [2583, 2933], 'circles).': [2584], 'identical': [2589], 'sequence': [2593], 'except': [2594], 'end.': [2598], '(20-μl)': [2601], '0.3': [2603], 'MgCl2,': [2605], '150': [2606], 'μmATP,': [2607], '20': [2608], 'nm': [2609], '[γ-32P]ATP,': [2610], 'pmol': [2613, 3804], 'ice': [2620], 'increasing': [2625], 'streptavidin': [2628], 'indicated,': [2630], '(10': [2634, 3785], 'ng)': [2635], 'added': [2637], 'reaction.': [2640], '10': [2649, 2776, 3585], 'min,': [2650], 'ATP': [2655, 2895, 4005, 4053, 4154, 4348], 'hydrolyzed': [2656], 'four': [2695, 2702], 'times,': [2696], 'average': [2699], 'experiments': [2703], 'error': [2707], 'bars': [2708], 'indicated.View': [2710], '1Directionality': [2716], 'unwinding': [2720, 4039, 4118, 4261, 4335], 'substrates.': [2724], 'linearized': [2729, 4148], 'asterisks': [2743], '20-μl': [2754], '3′-end-': [2768], 'terminated,': [2792], '12%': [2799], 'B': [2834], 'Thearrows': [2843], 'where': [2847], '(23-': [2851], '29-nt)': [2853], 'migrated.': [2854], 'An': [2855], 'arrowheadindicates': [2857], 'uncleaved': [2863], '(52-nt,': [2866], 'I).': [2868], 'closed': [2870], 'products,': [2878], '2–8': [2879], 'label,': [2886], 'unwound': [2928], 'label': [2931, 4367], 'released': [2932], 'arrowhead)': [2934], 'use': [2939], 'PhosphorImager': [2942], '(Molecular': [2943], 'Dynamics),': [2944], 'results': [2947], 'thebottom': [2951], 'figure.View': [2954], '(PPT)Table': [2959], 'IOligonucleotides': [2960], 'studyOligoSequence15′-CGA': [2964], 'ACA': [2965, 3005], 'ATT': [2966, 2976, 3040], 'CAG': [2967, 3007, 3038], 'CGG': [2968, 3008], 'CTT': [2969, 3009, 3082, 3172], 'TAA': [2970, 3010, 3017, 3018, 3102, 3103, 3121, 3122, 3135, 3154, 3165], 'CCG': [2971, 3011], 'GAC': [2972, 3012, 3032, 3062, 3072, 3097, 3116], 'GCT': [2973, 3013, 3028, 3033, 3041, 3044, 3098, 3117, 3158], 'CGAC': [2974], 'GCC': [2975], 'AAT': [2977, 2978, 3178], 'GTT': [2979, 3141, 3170], 'TTC-3′': [2980], '1-aThe': [2981], 'underline': [2982, 3187], 'indicates': [2983, 3025, 3129, 3188, 3212, 4189], 'theHpaII': [2984, 3189], 'site': [2986, 3191], 'linear': [2991, 3196, 3753, 4095], 'ssDNA.': [2993, 3755], '(52)': [2994], '1-bThe': [2995], 'parentheses': [2998, 3202], 'length': [3001, 3205], 'oligonucleotide.25′-CGA': [3004], 'AUU': [3006], 'CGA': [3014, 3066, 3099, 3118, 3138, 3157], 'CGC': [3015, 3046, 3100, 3119, 3171], 'CAT': [3016, 3043, 3101, 3120, 3133, 3152, 3177], 'TGT': [3019, 3104, 3123], 'TTT': [3020, 3089, 3090, 3091, 3092, 3093, 3094, 3095, 3105, 3111, 3112, 3113, 3114, 3124, 3142, 3143, 3144, 3145, 3146, 3147, 3148], 'C-3′': [3021, 3106, 3125], '1-cThe': [3022, 3126], 'bold': [3023, 3127, 3210], 'type': [3024, 3128, 3211], 'ribonucleotides.': [3026, 3130, 3213], '(52)35′-TGG': [3027], 'CAC': [3029, 3037, 3058, 3160], 'GTG': [3030, 3055, 3073, 3173], 'GTC': [3031, 3051], 'GGA': [3034], 'GGT': [3035], 'GAT': [3036], 'ATG': [3039, 3081], 'AGG': [3042, 3159], 'TTC': [3045], 'AAG': [3047, 3161, 3183], 'AGA': [3048, 3076, 3085], 'ACG': [3049], 'GGC': [3050, 3080], 'TGC': [3052, 3164], 'GTA': [3053], 'CCC': [3054], 'CAG-3′': [3056], '(90)45′-CTG': [3057], 'GGG': [3059], 'TAC': [3060], 'GCA': [3061, 3084, 3169], 'GCC-3′': [3063], '(21)55′-CAG': [3064], 'CGT': [3065, 3068, 3137, 3156], 'CCA': [3067], 'GAG': [3069], 'CCC-3′': [3070], '(21)65′-GGC': [3071], 'ATC': [3074], 'ACC': [3075], 'TGA': [3077], 'TTG': [3078], 'CTA': [3079], 'TCC': [3083, 3140, 3180], 'GAA': [3086], 'GC-3′': [3087], '(50)75′-TTT': [3088], 'TCG': [3096, 3115], '(55)85′-UUU': [3107], 'UUU': [3108, 3109, 3110], '(55)95′-TGA': [3131], 'AAA': [3132, 3151], 'TAT': [3134, 3153], 'TGG': [3136, 3155], 'GCG': [3139, 3162], 'TT-3′': [3149], '(56)105′-GGA': [3150], 'AAC': [3163], 'CGG-3′': [3166], '(51)115′-CCG': [3167], 'TTA': [3168, 3179], 'CCT': [3174], 'A-3′': [3175], '(25)125′-AGA': [3176], 'TCA': [3181], 'AGT': [3182], 'GGG-3′': [3184], '(27)1-a': [3185], 'ssDNA.1-b': [3198], 'oligonucleotide.1-c': [3208], 'Open': [3214], 'table': [3215], 'tab': [3219], 'following': [3221, 3708], 'proteins': [3222], 'commercially:': [3225], 'restriction': [3226], 'HpaII,': [3228], 'kinase,': [3231, 3800], 'terminal': [3233], 'transferase': [3234], 'Biolabs.': [3239], 'Streptavidin,': [3240], 'Klenow': [3242, 3740], 'I,': [3249], 'Biochemicals.': [3258], 'Schizosaccharomyces': [3259], 'pombe': [3260], '(35Zuo': [3264], 'Vermudez': [3266], 'V.': [3267], 'Zhang': [3268], 'G.': [3269], 'Kelman': [3270], 'Z.': [3271], '275:': [3278], '5153-5162Abstract': [3279], '(59)': [3287], 'generous': [3292], 'gift': [3293], 'Dr.': [3295], '(Sloan-Kettering': [3298], 'Institute).': [3299], '(HX-Dna2),': [3304], 'six': [3306], 'residues': [3308], 'Xpress': [3311], 'epitope': [3312], 'amino': [3315], 'terminus,': [3316], 'PCNA': [3351, 3382], 'cerevisiaewas': [3355], 'cloned': [3356], '(36Ayyagari': [3359], 'Impellizzeri': [3361], 'K.J.': [3362, 3465, 3522, 3592], 'Yoder': [3363], 'B.L.': [3364], 'Gary': [3365, 3466, 3523, 3593], 'S.L.': [3366, 3467, 3524, 3594], 'Burgers': [3367, 3468, 3525, 3595], 'P.M.': [3368], '4420-4429Crossref': [3374], '(186)': [3377], 'overexpressed': [3384], 'purified': [3386, 3410, 3504, 4285], 'according': [3387], 'procedure': [3390, 3757], '(37Fien': [3393, 3449, 3539, 3556], '1992;': [3400, 3456, 3546, 3563], '155-163Crossref': [3402, 3458, 3548, 3565], '(190)': [3405, 3461, 3551, 3568], 'RPA': [3408], 'protease-deficient': [3413], 'BJ2168': [3416], '(MATa,': [3417], 'ura3-52,': [3418], 'trp1-Δ63,leu2-Δ,': [3419], 'prb1-1122,': [3420], 'pep4-3,': [3421], 'prc1-407,gal2)': [3422], '(38Brill': [3425], 'S.J.': [3426], '342:': [3431], '92-95Crossref': [3432], '(189)': [3435], 'RFC': [3439, 3502, 3623, 3647], 'purification': [3440], 'combined': [3442], 'two': [3443], 'procedures': [3444], '39Gerik': [3464], 'P.M.J.': [3469, 3526, 3596], '1256-1262Crossref': [3475, 3532, 3602], '(66)': [3478, 3535, 3605], 'obtain': [3482], 'preparation': [3484, 3655], 'devoid': [3485], 'detectable': [3487, 3644], 'nuclease': [3488, 4046], 'activity.': [3489], 'Briefly,': [3490], 'crude': [3491], 'extracts': [3492], '60-liter': [3497], 'culture': [3498], 'BJ2168,': [3500], 'several': [3506], 'column': [3507, 3580, 3618, 3632], 'chromatographic': [3508], 'included': [3511, 4009], 'adsorption': [3513], 'elution': [3517], 'Affi-Gel': [3519], 'Blue': [3520], '(39Gerik': [3521, 3591], 'hydroxylapatite': [3538], 'ssDNA-cellulose': [3555], 'latter': [3572], 'fraction': [3573], 'dialyzed,': [3575], 'loaded': [3576], 'onto': [3577], 'PCNA-agarose': [3579], '(1.5': [3581], '×': [3582], '6': [3583, 4181], 'cm,': [3584], 'ml),': [3586], 'eluted': [3588], 'RFC-containing': [3608], 'fractions': [3609, 3624], 'pooled': [3611], 'concentrated': [3613], 'Mono': [3616, 3630], '(Amersham': [3619], 'Biotech).': [3621], '(∼100': [3625], 'μg)': [3626], 'aliquoted': [3634], 'stored': [3636], '−80': [3638], '°C.': [3639], 'Nuclease': [3640], 'barely': [3643], 'preparation,': [3648], 'silver-stained': [3650], 'gels': [3651], 'revealed': [3652, 3939], '95%': [3659], 'pure': [3660], '(data': [3661, 3922, 4134, 4337], 'shown).': [3663, 3924, 4136, 4339], 'determine': [3669], 'directionality': [3671, 4236, 4244], 'movement': [3675], 'constructed': [3677], '(40Park': [3681], '18910-18919Abstract': [3696], '(23)': [3704], 'modifications.': [3709], '(52-nt': [3715], 'oligomer)': [3716], 'annealed': [3717, 3801], '(4': [3721], 'pmol)': [3722, 3786], 'first': [3724, 4441], 'incorporating': [3727], 'chased': [3731], 'excess': [3733, 4346], 'unlabeled': [3734], 'dCTP': [3735], 'HpaII': [3750], 'yielded': [3758], '29-nt': [3768, 4162], 'To': [3770], '23-nt': [3781, 4108, 4170], 'fragment,': [3782], '4': [3803], 'sscDNA,': [3807], 'digested': [3810], 'HpaII.': [3812], 'characterize': [3820], 'HX-Dna2': [3825, 4121, 4159, 4475, 4521, 4576], 'Among': [3867], 'constructed,': [3871], 'examined': [3873, 4401], 'Y-': [3876], 'flap': [3878, 3916], '(5′-end': [3881], 'tails)': [3886], 'order': [3892], 'confirm': [3894], 'desired': [3899], 'specific': [3900, 3945], 'structure.': [3901], 'Y': [3906], 'resistant': [3909], 'expected,': [3913], 'whereas': [3914, 4484], 'result': [3926, 4188], 'mobility': [3931], 'change': [3932], 'upon': [3933, 4250], 'heat': [3934], 'treatment': [3935], 'possessed': [3943, 4418], 'structure': [3946, 4332], 'intended.': [3948], 'Standard': [3949], 'contained': [3954], '50': [3955], 'Tris-HCl': [3957], '(pH': [3958], '7.8),': [3959], 'mmdithiothreitol,': [3961], '0.25': [3962], 'mg/ml': [3963], 'bovine': [3964], 'serum': [3965], 'albumin,': [3966], 'unless': [4000], 'otherwise': [4001], 'indicated.': [4002, 4011], 'When': [4003], 'necessary,': [4004], 'Mg2+': [4007, 4055, 4352], 'Early': [4012], 'efforts': [4013], 'establish': [4015], 'polarity': [4017, 4040], 'translocation': [4019], 'hampered': [4026], 'weak': [4032], 'activities.': [4034], 'determined': [4036], 'blocking': [4044], 'ratios': [4051], 'consisted': [4093], '29-nucleotide': [4100], '(nt)': [4101], '(Fig.1).': [4113], 'Due': [4114], 'limited': [4117], 'failed': [4123], 'produce': [4125], '52-base': [4129], 'pair': [4130], 'displaced': [4141, 4160], 'shorter': [4143], '(Fig.': [4155, 4175, 4368, 4479, 4504, 4531, 4553], '1,': [4156, 4176, 4369], 'lanes': [4157, 4178, 4183, 4371, 4376, 4533, 4556], '4–6).': [4158], 'compare': [4177, 4370], '11': [4184], '12).': [4186], 'contrast': [4200], 'previous': [4203, 4233], 'report': [4204], 'translocated': [4207], 'opposite': [4210], '(41Budd': [4212, 4263], '7642-7646Crossref': [4225, 4276], '(150)': [4228, 4279], 'experimentally': [4241], 'determined.': [4242], 'based': [4249], 'observation': [4252, 4381], '5′-tailed': [4257, 4330], 'forked': [4258], 'By': [4282], 'nuclease-deficient': [4287], '(42Lee': [4289], 'D.W.': [4292], 'J.A.': [4296], 'Ryu': [4297], 'Kwon': [4299], 'Y.N.': [4300], 'Koo': [4303], 'H.S.': [4304], 'Nucleic': [4307], 'Acids': [4308], 'Res.': [4309], '28:': [4311], '2873-2881Crossref': [4312], '(71)': [4315], 'however,': [4318], 'dependent': [4325], 'fork': [4331], 'molar': [4345], '(2': [4349], 'mm)': [4350, 4354], 'over': [4351], '(1': [4353], 'reduced': [4355, 4501], 'release': [4363], '3': [4374], '6).': [4379], 'suggests': [4382], 'prefer': [4390], 'reason,': [4399], 'specificity': [4404], 'different': [4414], '3′-ssDNA': [4423], 'overhang': [4424], 'duplexed': [4430], 'regions': [4431, 4542], '(Fig.2': [4435], 'A).': [4436], 'low': [4445], 'convenience': [4450], 'quantification.': [4453], 'degraded': [4456], '5′-ssDNA': [4458], 'tails': [4459], 'most': [4460], 'efficiently.': [4461], '(69': [4467, 4489], '10.4': [4477], 'lane': [4482, 4507], '4),': [4483], '3′-tail': [4488, 4530], 'same': [4495], 'slightly': [4500], '(7.2': [4502], 'fmol)': [4503], '10).': [4508], 'estimated': [4510], 'efficiency': [4513], 'about': [4523], '2-fold': [4524], 'greater': [4525], '2,': [4532], 'and12).': [4535], 'extremely': [4551], 'poor': [4552], '16–18),': [4557], 'much': [4559], 'higher': [4560], 'levels': [4562], '(>200-fold)': [4563], 'accumulate': [4565], 'comparable': [4566], 'products.': [4569], '100': [4573], 'resulted': [4580], 'o': [4584]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2010544809', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2025-01-07T13:15:59.955023', 'created_date': '2016-06-24'}