Publication Information

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'https://openalex.org/W2233804928', 'https://openalex.org/W2331958521', 'https://openalex.org/W2337919554', 'https://openalex.org/W2502569966', 'https://openalex.org/W4256293485', 'https://openalex.org/W4293247451'], 'related_works': ['https://openalex.org/W67662248', 'https://openalex.org/W633173308', 'https://openalex.org/W4386783509', 'https://openalex.org/W4385385496', 'https://openalex.org/W4312356288', 'https://openalex.org/W4296030002', 'https://openalex.org/W3177804739', 'https://openalex.org/W2318344906', 'https://openalex.org/W2279743539', 'https://openalex.org/W1987175900'], 'abstract_inverted_index': {'ME1,': [0, 225, 1882, 3877, 4052], 'a': [1, 9, 64, 80, 226, 234, 289, 305, 543, 683, 732, 1055, 1082, 1088, 1394, 1569, 1693, 1925, 2089, 2099, 2228, 2280, 2403, 2551, 2834, 2936, 2969, 3010, 3102, 3215, 3242, 3315, 3320, 3460, 3495, 3514, 3567, 3573, 3583, 3615, 3919, 3944, 4367, 4403, 4498], 'type': [2, 227], 'I': [3, 228], 'ribosome-inactivating': [4, 229, 458], 'protein': [5, 230, 533, 633, 1251, 2039, 2068, 2090, 3662, 3671], '(RIP),': [6, 231], 'belongs': [7, 232], 'to': [8, 15, 62, 79, 115, 152, 159, 164, 212, 233, 240, 287, 304, 340, 377, 384, 389, 437, 625, 1263, 1290, 1342, 1582, 1679, 1769, 1866, 1903, 1931, 1984, 2004, 2943, 3084, 3120, 3214, 3276, 3394, 3407, 3459, 3617, 3624, 3635, 3676, 3721, 3884, 3889, 3892, 3992, 4051, 4102, 4113, 4198, 4212, 4230, 4238, 4285, 4324, 4341, 4398, 4439, 4474], 'family': [10, 235], 'of': [11, 32, 43, 47, 66, 100, 105, 121, 125, 135, 171, 176, 204, 236, 257, 268, 272, 291, 325, 330, 346, 350, 360, 396, 401, 429, 537, 621, 632, 660, 673, 678, 685, 734, 1063, 1150, 1294, 1383, 1426, 1436, 1454, 1465, 1535, 1588, 1602, 1620, 1628, 1664, 1696, 1719, 1727, 1766, 1862, 1872, 1881, 1908, 1921, 1945, 1993, 2108, 2117, 2163, 2169, 2194, 2203, 2217, 2235, 2353, 2375, 2491, 2632, 2717, 2734, 2753, 2903, 2907, 2939, 2951, 3002, 3049, 3071, 3114, 3175, 3224, 3246, 3252, 3270, 3307, 3339, 3349, 3358, 3363, 3375, 3378, 3387, 3390, 3398, 3446, 3463, 3479, 3494, 3528, 3562, 3570, 3630, 3803, 3818, 3853, 3935, 3948, 4002, 4025, 4055, 4068, 4081, 4127, 4147, 4184, 4204, 4218, 4244, 4253, 4272, 4334, 4345, 4356, 4364, 4380, 4414, 4431, 4480, 4509], 'enzymes': [12, 237, 486], 'long': [13, 238, 667], 'believed': [14, 239], 'possess': [16, 241], 'rRNA': [17, 242, 558, 665, 704, 1389, 3781, 3838, 4254, 4280], 'N-glycosidase': [18, 243, 3738], 'activity': [19, 113, 244, 338, 820, 1049, 1080, 1266, 1382, 1601, 1880, 3739, 3817, 4008, 4080, 4337, 4377, 4445], 'directed': [20, 245], 'solely': [21, 246], 'at': [22, 137, 247, 362, 1987, 2264, 2271, 2317, 2324, 2371, 2497, 2512, 2586, 2643, 2741, 2872, 2892, 2916, 2972, 2991, 3033, 3205, 3238, 3381, 3932, 3969, 4028, 4046, 4060, 4115, 4172, 4186, 4310, 4434, 4441, 4451, 4458, 4476], 'the': [23, 29, 41, 45, 106, 118, 147, 169, 177, 201, 248, 254, 266, 270, 331, 343, 372, 394, 402, 426, 548, 556, 619, 622, 626, 629, 661, 669, 832, 1060, 1071, 1091, 1159, 1168, 1227, 1231, 1238, 1260, 1291, 1355, 1381, 1434, 1455, 1461, 1532, 1566, 1585, 1599, 1617, 1626, 1635, 1715, 1720, 1725, 1728, 1767, 1853, 1860, 1869, 1878, 1906, 1919, 2189, 2274, 2379, 2387, 2415, 2421, 2426, 2443, 2493, 2576, 2711, 2736, 2751, 2770, 2774, 2801, 2881, 2899, 2919, 2940, 2966, 3085, 3093, 3110, 3116, 3129, 3222, 3250, 3268, 3278, 3298, 3308, 3330, 3342, 3361, 3364, 3376, 3385, 3388, 3399, 3408, 3425, 3442, 3476, 3492, 3526, 3636, 3660, 3666, 3774, 3778, 3784, 3810, 3815, 3825, 3850, 3916, 3927, 3933, 3946, 3959, 3989, 4000, 4013, 4022, 4078, 4144, 4202, 4209, 4248, 4262, 4267, 4289, 4297, 4342, 4375, 4415, 4481, 4507], 'universally': [24, 249, 655], 'conserved': [25, 250, 550, 656, 1722], 'residue': [26, 251, 546, 658], 'A4324': [27, 252, 659], 'in': [28, 88, 195, 253, 313, 420, 491, 555, 703, 1158, 1167, 1442, 1446, 1674, 1689, 1707, 1710, 1716, 1724, 1735, 1758, 1761, 1800, 1956, 2036, 2224, 2254, 2304, 2310, 2335, 2402, 2410, 2607, 2662, 2689, 2750, 2779, 2817, 2878, 2898, 2968, 2981, 3133, 3172, 3241, 3282, 3441, 3513, 3572, 3593, 3654, 3724, 3771, 3813, 3849, 3956, 3999, 4016, 4021, 4039, 4071, 4095, 4136, 4157, 4177, 4201, 4216, 4247, 4301, 4315, 4390, 4419, 4504], 'sarcin/ricin': [30, 255], 'loop': [31, 256, 554, 1169], 'large': [33, 258, 557], 'eukaryotic': [34, 259, 662], 'and': [35, 56, 103, 111, 123, 260, 281, 328, 336, 348, 494, 496, 551, 635, 742, 828, 1059, 1244, 1288, 1451, 1622, 1634, 1676, 1709, 1910, 1915, 1924, 2008, 2047, 2052, 2067, 2094, 2102, 2126, 2159, 2172, 2215, 2230, 2232, 2250, 2289, 2300, 2315, 2346, 2364, 2398, 2408, 2423, 2437, 2461, 2466, 2505, 2553, 2573, 2575, 2605, 2628, 2634, 2650, 2769, 2809, 2826, 2890, 2901, 2912, 2963, 2986, 2993, 3022, 3068, 3082, 3123, 3141, 3162, 3200, 3370, 3410, 3422, 3432, 3488, 3522, 3638, 3658, 3696, 3735, 3782, 3902, 3937, 3977, 4053, 4086, 4162, 4192, 4222, 4351, 4378, 4396, 4470, 4493], 'prokaryotic': [36, 261], 'rRNAs.': [37, 262], 'We': [38, 263, 4141], 'have': [39, 264, 488, 680, 1075, 1668, 1857], 'investigated': [40, 265], 'effect': [42, 267], 'modifying': [44, 269], 'structure': [46, 271, 1085, 1152, 1262, 1293, 1396, 1667, 1760, 4344], 'nonribosomal': [48, 273, 1911], 'RNA': [49, 174, 274, 399, 822, 1307, 1324, 1364, 1437, 1632, 1665, 1698, 1702, 1759, 2451, 2523, 2529, 2618, 2635, 2687, 3258, 3379, 3537, 3737, 4153, 4369], 'substrates': [50, 128, 207, 275, 353, 432, 1053, 1386, 1589, 1890, 2636, 3835, 4110, 4350], 'on': [51, 117, 276, 342, 790, 1050, 1336, 1888, 2593, 2713, 2788, 3475, 3805, 3820, 3830, 4149, 4168, 4366, 4382, 4448, 4455], 'their': [52, 130, 210, 218, 277, 355, 435, 443, 538, 1469, 1806], 'interaction': [53, 131, 278, 356, 1907, 4106], 'with': [54, 132, 209, 214, 279, 357, 434, 439, 628, 1090, 1161, 1385, 1771, 1805, 1808, 1905, 1918, 1998, 2014, 2044, 2064, 2227, 2342, 2360, 2366, 2557, 2571, 2581, 2790, 2799, 2828, 2946, 3046, 3151, 3160, 3208, 3249, 3264, 3314, 3329, 3453, 3491, 3503, 3566, 3643, 3742, 3790, 3876, 3925, 3975, 4063, 4233, 4370, 4394], 'ME1': [55, 59, 112, 221, 280, 284, 337, 446, 1909, 1965, 2024, 3152, 3365, 3391, 3447, 3565, 3677, 3728, 3776, 3796, 3804, 3829, 3976, 3982, 4007, 4033, 4069, 4082, 4148, 4164, 4199, 4245, 4306, 4335, 4354, 4365, 4381, 4395, 4444, 4475, 4491], 'other': [57, 223, 282, 448, 786, 1232, 1772, 1809], 'RIPs.': [58, 162, 283, 387, 1603, 1873], 'was': [60, 95, 285, 320, 666, 1732, 1901, 1928, 1940, 1982, 2025, 2070, 2110, 2141, 2186, 2260, 2277, 2356, 2637, 2777, 2783, 2804, 2842, 2885, 2910, 2928, 2979, 3006, 3096, 3107, 3118, 3131, 3232, 3310, 3327, 3366, 3590, 3612, 3729, 3740, 3882, 4083, 4093, 4165, 4321, 4392, 4427, 4446], 'shown': [61, 286, 693, 1700, 3653, 3770, 3955, 4156, 4314, 4418, 4503], 'depurinate': [63, 288, 4308], 'variety': [65, 290, 684, 733], 'partially': [67, 172, 292, 397, 3832, 4128, 4151, 4383], 'denatured': [68, 173, 293, 398, 3833, 4129, 4152, 4384], 'nucleic': [69, 126, 188, 294, 351, 413, 735, 1864, 2577, 2775, 2811, 3821, 3879, 3921, 3950, 4108, 4130, 4348], 'acids,': [70, 295, 3822], 'randomly': [71, 296], 'removing': [72, 297, 542], 'adenine': [73, 298, 545, 657, 699, 729, 1220, 1299, 2927], 'residues': [74, 84, 299, 309, 730, 1300], 'from': [75, 85, 150, 300, 310, 375, 547, 700, 731, 825, 1684, 1885, 1942, 2056, 2114, 2130, 2358, 2386, 2420, 2442, 2833, 3221, 3319, 3745, 3840, 3887, 4409], 'single-stranded': [76, 301, 482, 4003, 4347], 'regions': [77, 302], 'and,': [78, 303], 'lesser': [81, 306], 'extent,': [82, 307], 'guanine': [83, 308], 'wobble': [86, 311], 'base-pairs': [87, 312], 'hairpin': [89, 314], 'stems.': [90, 315], 'A': [91, 316, 1951, 2350, 3266, 3657], 'defined': [92, 317, 4499], 'sequence': [93, 318, 1092, 2048, 2133, 3216, 4487, 4500], 'motif': [94, 319, 1927], 'not': [96, 321, 1254, 1379, 1459, 1733, 1929, 3965, 4134, 4139, 4166, 4496], 'required': [97, 322], 'for': [98, 144, 323, 369, 1259, 1422, 1934, 2268, 2286, 2293, 2321, 2368, 2515, 2583, 2640, 2744, 2785, 2875, 2895, 2975, 3098, 3202, 3235, 3334, 3341, 3415, 3510, 3519, 3525, 3540], 'recognition': [99, 110, 324, 335, 1936, 4492], 'non-paired': [101, 326], 'adenosines': [102, 327], 'cleavage': [104, 329, 617, 3412, 3931, 4137, 4355], 'N-glycosidic': [107, 332, 504, 4359], 'bond.': [108, 333], 'Substrate': [109, 334], 'appeared': [114, 339], 'depend': [116, 341], 'physical': [119, 344], 'availability': [120, 345], 'nucleotides,': [122, 347], 'denaturation': [124, 349, 2631, 3450], 'acid': [127, 352, 736, 3140, 3880, 3922, 3951, 4105, 4109, 4349], 'increased': [129, 354, 3119], 'ME1.': [133, 358, 1938, 4325], 'Pretreatment': [134, 359], 'mRNA': [136, 361, 3148, 3844, 4320, 4385, 4388, 4425, 4433, 4449], '75': [138, 363, 1999, 3996, 4213, 4452], '°C': [139, 364, 2326, 2514, 2588, 2743, 2874, 2894, 2974, 3035, 3104, 3207, 3240, 3891, 3971, 3997, 4030, 4048, 4062, 4117, 4214, 4287, 4437, 4453], 'rather': [140, 365, 1350], 'than': [141, 366, 784, 1351, 4454], '60': [142, 367, 4193], '°C,': [143, 368, 2273, 2918], 'example,': [145, 370, 1692], 'lowered': [146, 371], 'apparent': [148, 373, 3344, 3400], 'KD': [149, 374], '87.1': [151, 376], '73.9': [153, 378], 'nm,': [154, 379, 2995], 'making': [155, 380], 'it': [156, 381, 690, 1677], 'more': [157, 382], 'vulnerable': [158, 383], 'depurination': [160, 385, 1218, 4073, 4092, 4203, 4217, 4252], 'by': [161, 220, 386, 445, 535, 1241, 1574, 1591, 1613, 1714, 1898, 1937, 2042, 2062, 2074, 2112, 2188, 2392, 2458, 2463, 2591, 2623, 2709, 2764, 2815, 2846, 2924, 2934, 3158, 3166, 3229, 3262, 3294, 3312, 3354, 3531, 3665, 3732, 3828, 3913, 3967, 3973, 4058, 4196], 'Exposure': [163, 388], 'ME1in': [165, 390], 'vitro': [166, 391, 1708, 1717, 4391], 'completely': [167, 392], 'abolished': [168, 393], 'infectivity': [170, 395], 'transcripts': [175, 400, 823, 2524, 2619, 2688, 3041, 3149, 3439], 'potato': [178, 403, 468], 'spindle': [179, 404, 469, 2519], 'tuber': [180, 405, 470, 2520], 'viroid,': [181, 406], 'suggesting': [182, 407], 'that': [183, 200, 408, 425, 487, 500, 530, 694, 1077, 1285, 1392, 1565, 1701, 1803, 1877, 3326, 3794, 3905, 3961, 3981, 4032, 4043, 4090, 4182, 4266, 4305, 4331, 4352, 4423, 4490], 'RIPs': [184, 409, 531, 696, 787, 816, 1466, 1537, 2754, 2761, 3718, 3819], 'may': [185, 410, 1340, 1563], 'target': [186, 411, 1470], 'invading': [187, 412], 'acids': [189, 414, 1865, 2578, 2748, 2776, 2812, 4131], 'before': [190, 415, 2589, 2797, 3143, 3267, 4107], 'they': [191, 416], 'reach': [192, 417], 'host': [193, 418, 1352], 'ribosomes': [194, 419, 1353, 2288, 2359, 3743], 'vivo.': [196, 421, 1690], 'Our': [197, 422, 1874], 'data': [198, 423], 'suggest': [199, 424], 'extensive': [202, 427], 'folding': [203, 428, 1896], 'many': [205, 430, 4273], 'potential': [206, 431, 4346], 'interferes': [208, 433], 'ability': [211, 436, 1768], 'interact': [213, 438, 1770], 'RIPs,': [215, 440, 674, 1433], 'thereby': [216, 441, 3792], 'blocking': [217, 442], 'inactivation': [219, 444], '(or': [222, 447], 'RIPs).': [224, 449], 'Ribosome-inactivating': [450], 'proteins': [451, 1630, 1992, 2010, 3629, 3640], '(RIPs)': [452], '1The': [453], 'abbreviations': [454], 'used': [455, 3333, 3577, 3613, 4292], 'are:': [456], 'RIP,': [457, 2735], 'protein;': [459, 466], 'RTA,': [460], 'ricin': [461, 1072], 'A-chain;': [462], 'PAP,': [463], 'pokeweed': [464, 1249, 2118], 'antiviral': [465, 1250], 'PSTVd,': [467], 'viroid;': [471], 'Tricine,': [472], 'N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycine;': [473], 'SSO,': [474], 'small': [475, 2182, 2835, 3938], 'synthetic': [476, 2836], 'oligodeoxynucleotide;': [477], 'dsDNA,': [478], 'double-stranded': [479, 3907], 'DNA;': [480], 'ssDNA,': [481], 'DNA.': [483], 'are': [484, 788, 1235, 1605, 1611, 3941], 'cytotoxic': [485], 'been': [489, 528, 692, 1669], 'identified': [490, 682, 3848], 'plants,': [492], 'fungi,': [493], 'bacteria': [495], 'act': [497], 'as': [498, 1087, 1388, 1440, 1595, 1616, 1712, 1792, 2040, 2072, 2098, 2550, 2756, 2844, 3153, 3614, 3647, 3748, 3836, 3899, 4064, 4239, 4241, 4257], 'glycosidases': [499], 'specifically': [501, 1296], 'cleave': [502], 'nucleotide': [503, 1233, 3939], 'bonds': [505, 4360], '(1Endo': [506, 559], 'Y.': [507, 560, 580, 863, 1095, 1134, 1180, 1834], 'Mitsui': [508, 561], 'K.': [509, 513, 562, 566, 582, 1097, 1132, 1178, 1516], 'Motizuki': [510, 563], 'M.': [511, 564, 974, 1126, 1172, 1738, 1830, 1946, 1994, 2218, 2294, 2851, 2853, 3631, 3725], 'Tsurugi': [512, 565, 581, 1096], 'J.': [514, 567, 583, 644, 716, 774, 906, 908, 941, 976, 1098, 1114, 1271, 1483, 1778, 1813, 1836, 2861, 3550], 'Biol.': [515, 568, 584, 1099, 1116, 1273, 1652, 1780, 1814], 'Chem.': [516, 569, 585, 1100, 1815], '1987;': [517, 570, 586], '262:': [518, 571, 587], '5908-5912Abstract': [519, 572], 'Full': [520, 573, 589, 1104, 1819, 1821], 'Text': [521, 574, 590, 1105, 1820, 1822], 'PDF': [522, 575, 591, 1106, 1823], 'PubMed': [523, 576, 592, 610, 649, 720, 758, 778, 810, 850, 869, 884, 929, 958, 980, 1000, 1020, 1042, 1107, 1120, 1143, 1189, 1212, 1277, 1313, 1330, 1370, 1415, 1487, 1502, 1523, 1556, 1656, 1751, 1784, 1824, 1847, 1977, 2083, 2545, 2865, 3556, 3607, 3691, 3712, 3764, 3869], 'Google': [524, 577, 593, 613, 652, 723, 761, 781, 813, 853, 872, 887, 932, 961, 983, 1003, 1023, 1045, 1108, 1123, 1146, 1192, 1215, 1280, 1316, 1333, 1373, 1418, 1490, 1505, 1526, 1559, 1659, 1754, 1787, 1827, 1850, 1980, 2086, 2548, 2868, 3559, 3610, 3694, 3715, 3767, 3872], 'Scholar).': [525, 614, 653, 724, 782, 814, 1046, 1147, 1216, 1281, 1334, 1374, 1419, 1527, 1560, 1660, 1755, 1788, 1851, 2869, 3560, 3768, 3873], 'It': [526], 'has': [527, 691, 1699], 'proposed': [529], 'inhibit': [532], 'synthesis': [534, 634], 'virtue': [536], 'enzymatic': [539, 616, 671, 819, 1048, 1265, 1427, 1600, 1879, 3816, 4079, 4336, 4376], 'activity,': [540], 'selectively': [541], 'specific': [544, 1083, 1575, 1926, 3382, 3539], 'highly': [549, 1606, 1892, 4428], 'surface-exposed': [552], 'α-sarcin/ricin': [553], 'Scholar,': [578, 594, 762, 854, 873, 888, 933, 962, 984, 1004, 1024, 1109, 1124, 1193, 1317, 1491, 1506, 1828], '2Endo': [579], '8128-8130Abstract': [588], '3Hartley': [595], 'M.R.': [596, 642, 1113, 1270], 'Legname': [597], 'G.': [598, 875, 968], 'Osborn': [599], 'R.W.': [600, 640, 3545], 'Chen': [601], 'Z.': [602], 'Lord': [603, 971], 'J.M.': [604, 708, 935, 972, 1967, 3597, 3686, 3702, 3758, 3863], 'FEBS': [605, 1037], 'Lett.': [606, 1038], '1991;': [607], '290:': [608], '65-68Crossref': [609], 'Scopus': [611, 650, 721, 759, 779, 811, 851, 870, 885, 930, 959, 981, 1001, 1021, 1043, 1121, 1144, 1190, 1213, 1278, 1314, 1331, 1371, 1416, 1488, 1503, 1524, 1557, 1657, 1752, 1785, 1825, 1848, 1978, 2084, 2546, 2866, 3557, 3608, 3692, 3713, 3765, 3870], '(125)': [612], 'This': [615, 3587], 'prevents': [618], 'binding': [620], 'EF-2·GTP': [623], 'complex': [624], 'ribosome,': [627], 'subsequent': [630], 'arrest': [631], 'eventually': [636], 'cell': [637], 'death': [638], '(4Osborn': [639], 'Hartley': [641, 973, 1112, 1269], 'Eur.': [643], 'Biochem.': [645, 715, 773, 993, 1013, 1482, 2079, 2860], '1990;': [646, 955], '193:': [647], '401-407Crossref': [648], '(51)': [651], 'The': [654, 1148, 1217, 2138, 2181, 2331, 3015, 3305, 3418, 4088], '28': [663, 3779], 'S': [664, 3780, 4206, 4221, 4224], 'considered': [668], 'only': [670, 1460], 'substrate': [672, 1084, 1870, 1935, 2839, 3881], 'but': [675, 1467, 4006], 'several': [676, 695, 4442], 'lines': [677], 'evidence': [679], 'recently': [681], 'alternative': [686], 'substrates.': [687, 1912, 4154], 'For': [688, 1691], 'instance,': [689], 'can': [697, 727, 1704, 1763, 3910, 4307], 'release': [698, 728, 2832, 4001], 'multiple': [701, 4311], 'sites': [702, 1471, 3383, 4462], '(5Barbieri': [705], 'L.': [706, 745, 764, 793, 837, 970, 1398, 1473, 1510, 1539, 2857], 'Ferreras': [707], 'Barraco': [709], 'A.': [710, 770, 801, 925, 966, 1111, 1208, 1268, 1406, 1479, 1547, 1646, 3549], 'Ricci': [711], 'P.': [712, 747, 749, 751, 766, 768, 795, 799, 839, 841, 843, 900, 1304, 1361, 1400, 1404, 1475, 1477, 1541, 1545], 'Stirpe': [713, 752, 771, 802, 844, 1407, 1480, 1548], 'F.': [714, 753, 772, 803, 845, 986, 1006, 1128, 1174, 1408, 1481, 1512, 1549, 1742, 2855], '1992;': [717], '286:': [718], '1-4Crossref': [719], '(66)': [722], 'Furthermore,': [725], 'saporin-L1': [726], 'substrates,': [737, 1438, 1923, 4386], 'including': [738, 831, 1638], 'poly(A),': [739], 'mRNA,': [740], 'tRNA,': [741], 'DNA': [743, 791, 1391, 2101, 2416, 2503, 2633, 2661, 3301, 3316, 3908, 4004], '(6Barbieri': [744, 836], 'Gorini': [746, 767, 798, 838, 1403, 1476, 1544], 'Valbonesi': [748, 765, 794, 840, 1399, 1474, 1540], 'Castiglioni': [750, 842], 'Nature.': [754, 846, 954], '1994;': [755, 847, 977], '372:': [756, 848], '624Crossref': [757, 849], '(108)': [760, 852], '7Barbieri': [763], 'Pession': [769, 1478], '1996;': [775, 1484], '319:': [776, 1485], '507-513Crossref': [777, 1486], '(70)': [780, 1489], 'More': [783], '50': [785, 2501], 'active': [789, 3800, 4167], '(8Barbieri': [792, 1397, 1538], 'Bonora': [796, 1401, 1542], 'E.': [797, 1402, 1543, 1740, 1838], 'Bolognesi': [800, 1405, 1546], 'Nucleic': [804, 1137, 1183, 1409, 1550, 1745, 1841, 2539, 2747], 'Acids': [805, 1138, 1184, 1410, 1551, 1746, 1842, 2540], 'Res.': [806, 995, 1015, 1139, 1185, 1411, 1552, 1747, 1843, 2541], '1997;': [807, 1412, 1553], '25:': [808, 1413, 1554], '518-522Crossref': [809, 1414, 1555], '(266)': [812, 1417, 1558], 'Certain': [815], 'also': [817, 1468, 1530, 1687, 4322], 'display': [818], 'toward': [821], 'derived': [824], 'various': [826, 1863, 2644], 'plant': [827], 'animal': [829], 'viruses': [830], 'human': [833], 'immunodeficiency': [834], 'virus': [835], '9Ussery': [855], 'M.A.': [856], 'Irvin': [857, 876, 989], 'J.D.': [858, 877, 990, 1321], 'Hardesty': [859], 'B.': [860, 2166], 'Ann.': [861], 'N.': [862], 'Acad.': [864, 921, 1204], 'Sci.': [865, 922, 1205], '1977;': [866], '284:': [867], '431-440Crossref': [868], '(68)': [871], '10Aron': [874], 'Antimicrob.': [878], 'Agents': [879], 'Chemother.': [880], '1980;': [881], '17:': [882], '1032-1033Crossref': [883], '(72)': [886], '11McGrath': [889], 'M.S.': [890], 'Hwang': [891], 'K.M.': [892], 'Caldwell': [893], 'S.E.': [894], 'Gaston': [895], 'I.': [896], 'Luk': [897], 'K.C.': [898], 'Wu': [899], 'Ng': [901, 1031], 'V.L.': [902, 1497], 'Crowe': [903], 'S.': [904, 924, 964, 1136, 1182, 1207, 1508, 2859, 3746], 'Daniels': [905], 'Marsh': [907], 'Deihart': [909], 'T.': [910, 1130, 1176, 1744, 1775], 'Lekas': [911], 'P.U.': [912], 'Uennaari': [913], 'J.C.': [914, 3756, 3861], 'Yeung': [915], 'H.W.': [916], 'Lifson': [917], 'J.F.': [918], 'Proc.': [919, 1202], 'Natl.': [920, 1203], 'U.': [923, 1206], '1989;': [926, 2862], '86:': [927], '2844-2848Crossref': [928], '(320)': [931], '12Zarling': [934], 'Moran': [936], 'R.A.': [937, 1028, 2538], 'Haffar': [938], 'O.': [939], 'Sias': [940], 'Richmann': [942], 'D.D.': [943], 'Spina': [944], 'D.A.': [945], 'Myers': [946], 'D.E.': [947], 'Kuelbeck': [948], 'V.': [949], 'Ledbetter': [950], 'J.A.': [951], 'Uckun': [952, 991], 'F.M.': [953, 992, 1012], '347:': [956], '92-95Crossref': [957], '(195)': [960], '13Taylor': [963], 'Massiah': [965], 'Lomonossoff': [967], 'Roberts': [969], 'Plant': [975, 1972, 3602, 3707, 3759, 3864], '5:': [978], '827-835Crossref': [979], '(106)': [982], '14Rajamohan': [985], 'Venkatachalam': [987, 1009], 'T.K.': [988, 1010, 1026], 'Biophys.': [994, 1014, 1518], 'Commun.': [996, 1016], '1999;': [997, 1017, 1781, 1974, 3604, 3709], '260:': [998], '453-458Crossref': [999], '(84)': [1002], '15Rajamohan': [1005], 'Kurinov': [1007], 'I.V.': [1008], 'Unkun': [1011], '263:': [1018, 1102], '419-424Crossref': [1019], '(35)': [1022], '16Au': [1025], 'Collins': [1027], 'Lam': [1029], 'T.L.': [1030], 'T.B.': [1032], 'Fong': [1033], 'W.P.': [1034], 'Wan': [1035], 'D.C.C.': [1036], '2000;': [1039, 1310, 1367], '471:': [1040], '169-172Crossref': [1041], '(126)': [1044], 'However,': [1047, 1375], 'these': [1051, 1064, 1337, 1685, 4328], 'non-ribosomal': [1052, 1889, 1922, 3834], 'requires': [1054, 1081], 'high': [1056, 1961, 3568], 'protein:substrate': [1057], 'ratio,': [1058], 'biological': [1061], 'relevance': [1062], 'observations': [1065, 1579], 'is': [1066, 1891, 3797, 3923, 4338, 4361], 'unclear.': [1067], 'Several': [1068, 4461], 'studies': [1069, 1663, 1686], 'using': [1070, 1948, 2028, 2088, 2121, 2394, 2425, 2449, 2527, 3009, 3297, 3424, 3534, 4402], 'A-chain': [1073], '(RTA)': [1074], 'suggested': [1076], 'RIP': [1078, 1884], 'catalytic': [1079, 1462, 1533, 4145], 'such': [1086, 1387, 1594, 1614, 1791, 3831, 3898], 'tetraloop': [1089, 1261], '1GAGA4': [1093], '(17Endo': [1094], '1988;': [1101], '8735-8739Abstract': [1103], '18Marchant': [1110], 'Mol.': [1115, 1272, 1779], '1995;': [1117, 1274, 1816], '254:': [1118, 1275], '848-855Crossref': [1119, 1276], '(28)': [1122, 1279], '19Orita': [1125], 'Nishikawa': [1127, 1135, 1173, 1181], 'Shimayama': [1129, 1175], 'Taira': [1131, 1177], 'Endo': [1133, 1179], '1993;': [1140, 1186, 1209, 3553], '21:': [1141, 1187], '5670-5678Crossref': [1142, 1188], '(52)': [1145, 1191], 'stem': [1149, 1160], 'this': [1151, 1376, 1423, 1443, 4123], 'possesses': [1153], 'tilted': [1154], 'Watson-Crick': [1155], 'base': [1156, 1165, 1245, 3903], 'pairing': [1157, 1166], 'an': [1162, 1223, 1256, 1883, 2982, 3209, 3396, 3578, 3619, 3798], 'unusual': [1163], 'G1:A4': [1164], 'region': [1170, 2107], '(19Orita': [1171], '20Szewczak': [1194], 'A.A.': [1195], 'Moore': [1196], 'P.B.': [1197], 'Chan': [1198], 'Y.L.': [1199], 'Wool': [1200], 'I.G.': [1201], '90:': [1210], '9581-9585Crossref': [1211], '(226)': [1214], 'site': [1219], '(A2)': [1221], 'occupies': [1222], 'exposed': [1224], 'position': [1225, 3306], 'outside': [1226], 'solvent-accessible': [1228], 'loop,': [1229], 'whereas': [1230], 'bases': [1234, 3219, 4407], 'buried': [1236], 'within': [1237], 'phosphodiester': [1239, 3928], 'backbone': [1240, 3929], 'hydrogen': [1242, 3900], 'bonding': [1243, 3901], 'stacking.': [1246], 'In': [1247, 1852, 4011], 'contrast,': [1248, 4012], '(PAP)': [1252], 'does': [1253, 1378], 'exhibit': [1255, 1264], 'absolute': [1257], 'requirement': [1258], '(18Marchant': [1267], 'Recent': [1282], 'reports': [1283], 'propose': [1284], 'PAP': [1286, 1339, 1384], 'recognizes': [1287], 'binds': [1289], 'cap': [1292, 1395], 'mRNAs,': [1295], 'depurinating': [1297, 1347], 'downstream': [1298, 3220, 4408], '(21Hudak': [1301, 1358], 'K.A.': [1302, 1319, 1359], 'Wang': [1303, 1360], 'Tumer': [1305, 1322, 1362], 'N.E.': [1306, 1323, 1363], '(N.': [1308, 1325, 1365], 'Y.).': [1309, 1326, 1366], '6:': [1311, 1368], '369-380Crossref': [1312, 1369], '(92)': [1315, 1372], '22Hudak': [1318], 'Bauman': [1320], '2002;': [1327, 1653, 1748, 1844, 3761, 3866], '8:': [1328], '1148-1159Crossref': [1329], '(56)': [1332], 'Based': [1335], 'results,': [1338], 'bind': [1341], 'capped': [1343], 'viral': [1344, 1348], 'RNA,': [1345, 1730, 3359], 'subsequently': [1346, 2569], 'RNAs': [1349, 1604, 1799, 3005, 3169], 'during': [1354], 'infection': [1356], 'process': [1357, 3668], 'hypothesis': [1377], 'explain': [1380], 'or': [1390, 1631, 1794, 2558, 2686, 3444, 3466, 3994], 'lack': [1393], 'Possible': [1420], 'explanations': [1421], 'remarkable': [1424], 'array': [1425], 'activities': [1428, 1534], 'include': [1429], 'inherent': [1430], 'differences': [1431, 1445], 'among': [1432], 'diversity': [1435], 'or,': [1439], 'explored': [1441], 'paper,': [1444], 'experimental': [1447, 1576, 1592, 1899], 'conditions.': [1448, 1577], 'Temperature,': [1449], 'pH,': [1450], 'ionic': [1452, 1795], 'composition': [1453], 'assay': [1456, 2091], 'buffer': [1457, 2237, 2339, 2664, 2690, 2721, 2879, 2888, 3023, 3051, 3179, 3273, 3504, 4290], 'change': [1458], 'efficiency': [1463], '(kcat/Km)': [1464], '(7Barbieri': [1472], '23Chen': [1492], 'X.-Y.': [1493], 'Link': [1494], 'T.M.': [1495], 'Schramm': [1496], 'Biochemistry.': [1498], '1998;': [1499], '37:': [1500], '11605-11613Crossref': [1501], '(80)': [1504], '24Tang': [1507], 'Sie': [1509], 'Hou': [1511], 'Liu': [1513], 'W.-Y.': [1514], 'Ruan': [1515], 'Biochim.': [1517], 'Acta.': [1519], '2001;': [1520], '1519:': [1521], '192-198Crossref': [1522], '(9)': [1525], 'Experimental': [1528, 1789], 'conditions': [1529, 1900, 3517, 4291], 'determine': [1531], 'different': [1536, 1706, 4274], 'Efficient': [1561], 'catalysis': [1562, 4494], 'require': [1564, 4497], 'substrate(s)': [1567], 'assume': [1568], 'particular': [1570], 'structural': [1571, 1586, 1895, 3894], 'conformation': [1572, 1861, 1920], 'induced': [1573, 1590], 'These': [1578, 3673, 4226], 'prompted': [1580], 'us': [1581, 4101], 'ask': [1583], 'whether': [1584, 1682], 'changes': [1587, 1757], 'treatments': [1593], 'heating': [1596, 2965], 'could': [1597], 'affect': [1598], 'flexible': [1607], 'molecules': [1608, 1773, 1810], 'whose': [1609], 'structures': [1610, 1703], 'influenced': [1612], 'factors': [1615], 'vectorial': [1618], 'nature': [1619], 'transcription': [1621], 'translation,': [1623], 'trans-acting': [1624], 'factors,': [1625], 'presence': [1627, 2902, 3443, 3527], 'RNA-binding': [1629], 'chaperones,': [1633], 'cellular': [1636], 'environment,': [1637], 'ion': [1639], 'homeostasis': [1640], '(25Schroeder': [1641], 'R.': [1642, 1644, 1832, 3682], 'Grossberger': [1643], 'Pichler': [1645], 'Waldsich': [1647], 'C.': [1648], 'Curr.': [1649], 'Opin.': [1650], 'Struct.': [1651], '12:': [1654], '296-300Crossref': [1655], '(82)': [1658], 'Thus': [1661], 'far,': [1662], 'secondary': [1666, 4343], 'carried': [1670, 2638, 3007, 3233], 'out': [1671, 2639, 3008, 3234], 'almost': [1672], 'exclusively': [1673], 'vitro,': [1675], 'remains': [1678], 'be': [1680, 1705, 1932, 3722, 3911], 'proven': [1681], 'conclusions': [1683], 'apply': [1688], 'recent': [1694], 'study': [1695], 'telomerase': [1697, 1729], 'vivo,': [1711], 'exemplified': [1713], 'formation': [1718], 'phylogenetically': [1721], 'pseudoknot': [1723], '5′-part': [1726], 'which': [1731, 3589], 'observed': [1734, 4300], 'vivo': [1736, 1762], '(26Antal': [1737], 'Boros': [1739], 'Solymosy': [1741], 'Kiss': [1743], '30:': [1749, 1845], '912-920Crossref': [1750], '(79)': [1753], 'Importantly,': [1756], 'cause': [1764], 'loss': [1765], '(27Nikolcheva': [1774], 'Woodson': [1776], 'S.A.': [1777], '292:': [1782], '557-567Crossref': [1783], '(34)': [1786], 'variables': [1790], 'temperature': [1793, 3105, 3991, 4211], 'concentration': [1796, 2069, 3362, 3389, 3462], 'often': [1797], 'trap': [1798], 'inactive': [1801], 'conformations': [1802], 'interfere': [1804, 1904], 'interactions': [1807, 3897], '(28Herschlag': [1811], 'D.': [1812, 2534], '270:': [1817], '20871-20874Abstract': [1818], '(603)': [1826], '29Bonin': [1829], 'Zhu': [1831], 'Klaue': [1833], 'Oberstrass': [1835], 'Oesterschulze': [1837], 'Nellen': [1839], 'W.': [1840], 'e81Crossref': [1846], '(33)': [1849], 'present': [1854, 3723], 'study,': [1855, 4124], 'we': [1856, 3576, 3823], 'systematically': [1858], 'perturbed': [1859], 'further': [1867, 2026, 2351, 3730, 4373], 'understand': [1868], 'specificity': [1871, 1914, 4379], 'results': [1875, 4227, 4329, 4508], 'demonstrate': [1876], 'Mirabilis': [1886], 'expansa,': [1887], 'structure-dependent.': [1893], 'Extensive': [1894], 'caused': [1897], 'found': [1902, 1930, 3720], 'Enzymatic': [1913], 'kinetics': [1916], 'vary': [1917], 'necessary': [1933], 'Proteins—ME1': [1939], 'purified': [1941, 2462, 3157, 3731], 'storage': [1943], 'roots': [1944, 2116, 3852], 'expansa': [1947, 1995, 2219, 2295, 3632, 3726], 'immunoaffinity': [1949], 'chromatography.': [1950], 'polyclonal': [1952, 3584], 'antibody': [1953], 'raised': [1954, 3591], 'previously': [1955, 3592, 3719, 3750], 'our': [1957, 3594], 'laboratory': [1958, 3595], 'against': [1959], 'reverse-phase': [1960], 'pressure': [1962], 'liquid': [1963, 2225], 'chromatography-purified': [1964], '(30Vivanco': [1966, 3596], 'Savary': [1968, 3598, 3703], 'B.J.': [1969, 3599, 3704], 'Flores': [1970, 3600, 3705], 'H.E.': [1971, 3601, 3706], 'Physiol.': [1973, 3603, 3708, 3760, 3865], '119:': [1975, 3605, 3710], '1447-1456Crossref': [1976, 3606, 3711], '(89)': [1979, 2547, 3609, 3714], 'Scholar)': [1981, 2087, 2549, 3695], 'coupled': [1983], 'CNBr-activated': [1985, 3625], 'Sepharose': [1986], 'pH': [1988, 2002, 2018, 2258, 2308, 2475, 2669, 2695, 2726, 2957, 3066, 3183, 3457, 3644], '8.0.': [1989], 'Total': [1990, 3627], 'root': [1991, 3628], 'were': [1996, 2011, 2054, 2060, 2161, 2222, 2333, 2384, 2418, 2440, 2456, 2510, 2525, 2568, 2579, 2620, 2707, 2739, 2762, 2813, 2922, 2989, 3044, 3156, 3170, 3260, 3292, 3352, 3392, 3404, 3420, 3451, 3472, 3501, 3508, 3633, 3641, 3964, 4049, 4111, 4228, 4282, 4472, 4512], 'equilibrated': [1997], 'mm': [2000, 2016, 2239, 2242, 2245, 2248, 2252, 2256, 2298, 2302, 2306, 2337, 2344, 2348, 2473, 2478, 2481, 2484, 2487, 2499, 2609, 2616, 2667, 2672, 2675, 2693, 2698, 2701, 2704, 2724, 2729, 3029, 3053, 3056, 3060, 3064, 3181, 3186, 3189, 3192, 3195, 3198, 3254, 3455], 'Tris-HCl,': [2001, 2257, 2307, 2474, 2694, 2725, 3182], '8.0,': [2003], 'facilitate': [2005], 'protein-ligand': [2006], 'interaction,': [2007], 'immunobound': [2009, 3639], 'then': [2012, 2142, 2621, 2964, 3473], 'eluted': [2013, 3642], '100': [2015, 2233, 3185, 3371, 3467, 4066, 4242], 'glycine-HCl,': [2017], '2.7,': [2019], 'containing': [2020, 2471, 2598, 2731, 2773, 2822, 2959, 3286], '0.5': [2021, 2411], 'm': [2022, 2284, 2291, 2603, 2792, 2824, 2953, 2961, 3288], 'NaCl.': [2023, 3030], 'separated': [2027], 'cation-exchange': [2029, 3733], 'chromatography': [2030, 3580], '(POROS': [2031], 'HS;': [2032], 'Applied': [2033], 'Biosystems),': [2034], 'resulting': [2035, 2275], '>99%': [2037], 'pure': [2038], 'judged': [2041], 'SDS-PAGE': [2043, 2063], 'silver': [2045, 2065, 3295], 'staining': [2046, 2409, 3296], 'analysis.': [2049], 'Purified': [2050], 'RTA': [2051], 'saporin-S6': [2053], 'purchased': [2055], 'Sigma.': [2057], 'Their': [2058], 'purities': [2059], 'checked': [2061], 'staining,': [2066], 'determined': [2071, 3353], 'described': [2073, 2845, 3154, 3749], 'Bradford': [2075], '(31Bradford': [2076], 'M.M.': [2077], 'Anal.': [2078], '1976;': [2080], '72:': [2081], '248-254Crossref': [2082], '(216440)': [2085], 'kit': [2092, 2431], '(Bio-Rad)': [2093], 'bovine': [2095, 2679], 'serum': [2096, 2680], 'albumin': [2097], 'standard.': [2100], 'Oligonucleotide—The': [2103], 'open': [2104, 2381], 'reading': [2105, 2382], 'frame': [2106, 2383], 'pap-h': [2109, 2380, 3225, 3325, 4319, 4387, 4424, 4432], 'amplified': [2111, 2385], 'PCR': [2113, 2139, 2393], 'hairy': [2115, 3851], '(Phytolacca': [2119], 'americana)': [2120], 'gene-specific': [2122, 2395], 'primers': [2123, 2396], '5E.30': [2124, 2397], '(5′-ATGCATGTTCATCTGATCAATCATAAAAGT-3′)': [2125], '3E.28': [2127], '(5′-ATCAGAATCCCTGAAATAGATTACCAAG-3′)': [2128], 'designed': [2129], 'its': [2131, 2931, 3736, 4410], 'cDNA': [2132], '(GenBank™/EBI': [2134], 'accession': [2135], 'number': [2136], 'AY071928).': [2137], 'product': [2140], 'subcloned': [2143], 'into': [2144, 2887, 2930], 'pGEM®-T': [2145, 2149, 2389, 2445, 3321], 'Easy': [2146, 2150, 2390, 2446, 3322], 'vector': [2147], '(Promega).': [2148, 2453, 3304], 'recombinant': [2151], 'plasmids': [2152, 2391], 'encoding': [2153, 2378, 3324, 3845], 'defense-related': [2154], 'genes': [2155], 'B26,': [2156, 2434], 'Tom': [2157, 2435], 'RP-O′b,': [2158, 2436], 'At2g14610': [2160, 2438], 'gifts': [2162], 'Dr.': [2164], 'Christopher': [2165], 'Lawrence': [2167, 3753, 3858], '(Department': [2168, 2193], 'Bioagricultural': [2170], 'Sciences': [2171], 'Pest': [2173], 'Management,': [2174], 'Colorado': [2175, 2196], 'State': [2176, 2197], 'University,': [2177, 2198], 'Fort': [2178, 2199], 'Collins,': [2179, 2200], 'CO).': [2180, 2201], 'oligonucleotide': [2183, 2837, 3210], '23SSO-A12': [2184], '(5′-GGGCCGGCGGUACCGCCGGCGCC-3′)': [2185], 'synthesized': [2187, 2526, 4389], 'Macromolecular': [2190], 'Resources': [2191], 'Facility': [2192], 'Biochemistry,': [2195], 'Isolation': [2202], 'Ribosomes—To': [2204], 'isolate': [2205], 'ribosomes,': [2206, 2296, 3842], 'yeast': [2207, 2287, 3841], 'cells': [2208], '(10': [2209, 2666, 2723, 2883, 3470], 'g,': [2210], 'Saccharomyces': [2211], 'cerevisiae': [2212, 3747], 'strain': [2213], 'YPH500)': [2214], 'leaves': [2216], '(50': [2220], 'g)': [2221], 'ground': [2223], 'N2': [2226], 'mortar': [2229], 'pestle,': [2231], 'ml': [2234, 2945, 2950], 'extraction': [2236, 2465, 3159], '(200': [2238, 3036], 'KCl,': [2240, 2673, 2699, 3187], '25': [2241, 2244, 2251, 2305, 2336, 2343, 3069], 'MgCl2,': [2243, 2479, 2676, 2702, 3190], 'EGTA,': [2246], '200': [2247, 2255, 3218, 4406], 'sucrose,': [2249], 'β-mercaptoethanol': [2253], '9.0)': [2259], 'added.': [2261], 'After': [2262, 2400], 'centrifugation': [2263], '10,000': [2265], '×': [2266, 2319], 'g': [2267, 2320], '20': [2269, 2297, 2489, 2896, 3188, 3191, 3203, 3247, 3454], 'min': [2270, 2787, 2897, 2915, 3091, 3100, 3127, 3204, 3237], '4': [2272, 2322, 2325], 'supernatant': [2276], 'layered': [2278], 'onto': [2279], 'sucrose': [2281, 2285, 2292], 'cushion': [2282], '(1': [2283], '2': [2290, 2369, 2483, 2584, 3197], 'KCl': [2299, 2345], '5': [2301, 2347, 2602, 3028, 3173], 'MgCl2': [2303], '7.6)': [2309, 2341], 'Ti-70': [2311], 'tubes': [2312, 2712], '(Beckman': [2313], 'Instruments)': [2314], 'centrifuged': [2316], '200,000': [2318], 'h': [2323, 2370, 2585, 3125], '(L-70': [2327], 'Ultracentrifuge,': [2328], 'Beckman': [2329], 'Instruments).': [2330], 'pellets': [2332], 'resuspended': [2334, 3171], 'Tris-HCl': [2338], '(pH': [2340, 2795], 'MgCl2.': [2349], 'preparation': [2352], 'protein-free': [2354], 'rRNAs': [2355, 4170, 4185, 4269, 4309], 'extracted': [2357, 2570], 'phenol:chloroform': [2361, 2464, 2765, 3161], '(1:1,': [2362, 2766], 'v/v)': [2363, 2767], 'precipitated': [2365, 2580, 2805], 'ethanol': [2367, 2467, 2582, 2624, 2909, 3167], '–80': [2372, 2587, 2917], '°C.': [2373, 4174], 'Preparation': [2374], 'Substrates—DNA': [2376], 'fragments': [2377, 2417, 4271], 'corresponding': [2388, 2444], '3E.28.': [2399], 'electrophoresis': [2401, 2592, 2816, 3001, 3281], '1.5%': [2404], '(w/v)': [2405, 2595, 2613, 2819], 'agarose': [2406], 'gel': [2407, 2422, 2429, 3000, 3021, 3130, 3429], 'mg·ml–1': [2412], 'ethidium': [2413, 2829], 'bromide,': [2414], 'excised': [2419], 'recovered': [2424, 2622, 2923], 'Quantum': [2427], 'Prep': [2428], 'slice': [2430], '(Bio-Rad).': [2432, 3435], 'pap-h,': [2433], 'mRNAs': [2439], 'transcribed': [2441], 'plasmid': [2447, 2531, 3323], 'DNAs': [2448, 2455], 'T7': [2450, 2508], 'polymerase': [2452, 2509], 'Template': [2454], 'linearized': [2457], 'SpeI': [2459], 'digestion': [2460], 'precipitation.': [2468, 2625, 3168], 'Transcription': [2469, 2566], 'reactions': [2470, 2567], '40': [2472, 2728, 2976, 3253], '7.5,': [2476], '9': [2477], '10': [2480, 2486, 2745, 2914, 3465], 'NaCl,': [2482, 3054], 'spermidine,': [2485, 3196], 'dithiothreitol,': [2488, 3193], 'units': [2490], 'RNasin,': [2492], 'four': [2494, 2554], 'nucleoside': [2495, 2555], 'triphosphates': [2496, 2556], '1.5': [2498], 'each,': [2500], 'nm': [2502, 2659], 'templates,': [2504], '3': [2506, 2674, 3059], 'units/μl': [2507], 'incubated': [2511, 2740, 2749, 2784, 2891, 3440, 4393], '37': [2513, 2742, 2893, 4116], '1': [2516, 2732, 2791, 2944, 3124, 3194], 'h.': [2517], 'Potato': [2518], 'viroid': [2521, 3520], '(PSTVd)': [2522], 'SP6': [2528], 'polymerase,': [2530], 'pST64-B5': [2532], '(32Cress': [2533], 'Kiefer': [2535], 'M.C.': [2536], 'Owens': [2537], '1983;': [2542], '11:': [2543], '6821-6835Crossref': [2544], 'template,': [2552], 'without': [2559], 'supplemental': [2560], '5′-[α-32P]UTP': [2561], '(3000': [2562], 'Ci/mmol;': [2563], 'Amersham': [2564], 'Biosciences).': [2565], 'phenol': [2572], 'chloroform,': [2574], 'purification': [2590], '6%': [2594, 2818, 3283], 'polyacrylamide': [2596, 2820, 3284], 'gels': [2597, 2821, 3285], '1×': [2599, 3076], 'Tris-borate-EDTA': [2600], 'buffer,': [2601, 2956], 'urea': [2604, 2825], 'elution': [2606, 3667], '500': [2608], 'ammonium': [2610], 'acetate,': [2611], '0.1%': [2612], 'SDS,': [2614], '0.1': [2615, 2952], 'EDTA.': [2617], 'Heat': [2626], 'Treatment': [2627], 'Depurination': [2629], 'Analysis—Partial': [2630], '30': [2641, 2786, 2876, 3038, 3099, 3236, 3888, 3970], 's': [2642, 2877, 4097], 'temperatures': [2645, 3885, 4189, 4435], '(30,': [2646], '45,': [2647], '60,': [2648], '75,': [2649], '90': [2651, 3890, 4029, 4061, 4286], '°C).': [2652], 'Each': [2653], 'reaction': [2654, 2737, 3244, 3826], '(15': [2655], 'μl)': [2656, 3275, 3471], 'contained': [2657, 3025, 3669], '∼150': [2658], 'either': [2660, 3464], 'incubation': [2663, 2720, 3263, 3875, 3974, 4054], 'PS-1': [2665], 'Tricine-KOH,': [2668], '8.7,': [2670], '2.5': [2671, 2697], '3.75': [2677], 'μg/ml': [2678], 'albumin,': [2681], '0.005%': [2682], '(v/v)': [2683, 3135, 3138], 'Tween': [2684], '20)': [2685], 'PS-2': [2691], '(1.25': [2692], '7.4,': [2696], '1.25': [2700], '0.01': [2703], 'EDTA).': [2705], 'Reactions': [2706], 'quenched': [2708], 'placing': [2710], 'ice.': [2714], 'Following': [2715, 2759, 2870, 3031, 3280], 'addition': [2716, 3251, 3269], '85': [2718], 'μlofRIP': [2719], 'PS-3': [2722, 2889], '7.2,': [2727], 'KCl)': [2730], 'ng': [2733], 'mixtures': [2738], 'min.': [2746, 2977], 'absence': [2752, 2900, 3445], 'served': [2755], 'negative': [2757], 'controls.': [2758], 'incubation,': [2760], 'removed': [2763], 'extraction,': [2768], 'aqueous': [2771], 'phase': [2772], 'divided': [2778], 'half.': [2780], 'One': [2781, 2905], 'aliquot': [2782, 2803], 'ice': [2789], 'aniline': [2793, 3978, 4125, 4277], 'acetate': [2794, 2955], '4.5)': [2796], 'precipitation': [2798], 'ethanol;': [2800], 'second': [2802], 'directly.': [2806], 'Both': [2807], 'aniline-treated': [2808], 'untreated': [2810], 'fractionated': [2814], '7': [2823, 3287], 'stained': [2827], 'bromide.': [2830], 'Adenine': [2831], '(SSO)': [2838], '(i.e.': [2840, 4190], '23SSO-A12)': [2841], 'measured': [2843, 2980, 3414], 'Zamboni': [2847], 'et': [2848], 'al.': [2849], '(33Zamboni': [2850], 'Brigotti': [2852], 'Rambelli': [2854], 'Montanaro': [2856], 'Sperti': [2858], '259:': [2863], '639-643Crossref': [2864], '(95)': [2867], 'preincubation': [2871, 3968, 3990, 4183, 4210], '45': [2873, 3126, 3993, 4191], 'PS-2,': [2880], 'SSO': [2882], 'nm)': [2884], 'diluted': [2886, 3045, 3452], 'RIP.': [2904, 3801], 'volume': [2906, 3245], 'cold': [2908], 'added,': [2911], 'after': [2913, 3448, 4276], 'ethanol-soluble': [2920, 2941], 'fractions': [2921, 2942], 'centrifugation.': [2925], 'Free': [2926], 'converted': [2929], 'etheno': [2932], 'derivative': [2933], 'diluting': [2935], '0.2-ml': [2937], 'portion': [2938], 'H2O,': [2947], 'adding': [2948], '0.4': [2949], 'sodium': [2954, 3057, 3255], '5.1,': [2958], '0.14': [2960], 'chloroacetaldehyde,': [2962], 'samples': [2967], 'water': [2970], 'bath': [2971], '80': [2973], 'Fluorescence': [2978], 'Aminco-Bowman': [2983], 'spectrophotofluorometer.': [2984], 'Excitation': [2985], 'emission': [2987], 'wavelengths': [2988], 'set': [2990], '280': [2992], '400': [2994], 'respectively.': [2996], 'Temperature-gradient': [2997], 'Gel': [2998, 3426], 'Electrophoresis—Temperature-gradient': [2999], '32P-labeled': [3003], 'PSTVd': [3004, 3040, 3436, 3529], 'commercially': [3011], 'available': [3012, 4358], 'apparatus': [3013], '(Qiagen).': [3014], 'horizontal': [3016], '5%': [3017], 'polyacrylamide,': [3018], '0.17%': [3019], 'bisacrylamide': [3020], 'reservoirs': [3024], '0.2×': [3026], 'Tris-borate-EDTA,': [3027, 3077], 'preelectrophoresis': [3032], '26': [3034, 4205, 4220], 'V,': [3037, 3122], 'min),': [3039], '(∼40,000': [3042], 'cpm)': [3043], '165': [3047], 'μl': [3048, 3070, 3174, 3248], 'loading': [3050, 3072, 3272], '(18': [3052], '17': [3055], 'cacodylate,': [3058], 'cacodylic': [3061], 'acid,': [3062], '0.2': [3063], 'EDTA,': [3065], '7.0)': [3067], 'dye': [3073], '(50%': [3074], 'glycerol,': [3075], '2%': [3078], 'bromphenol': [3079], 'blue-xylene': [3080], 'cyanol)': [3081], 'applied': [3083, 3634], 'single': [3086, 3574, 3661], '12-cm': [3087], 'sample': [3088], 'slot.': [3089], 'Sixty': [3090], 'later,': [3092, 3128], 'current': [3094], 'flow': [3095], 'stopped': [3097], 'while': [3101], '25–65': [3103], 'gradient': [3106], 'established': [3108], 'across': [3109], 'gel.': [3111], 'Upon': [3112], 'resumption': [3113], 'electrophoresis,': [3115], 'voltage': [3117], '350': [3121], 'fixed': [3132], '10%': [3134], 'ethanol,': [3136], '1%': [3137], 'acetic': [3139], 'dried': [3142], 'overnight': [3144], 'autoradiography.': [3145], 'Primer': [3146, 3227], 'Extension—pap-h': [3147], 'treated': [3150, 3924], 'above': [3155], 'chloroform:isoamyl': [3163], 'alcohol': [3164], 'followed': [3165, 3972, 4195], '2×': [3176], 'primer': [3177, 3211, 3332, 3335, 4399, 4404, 4510], 'extension': [3178, 3228, 3290, 4400, 4511], '(100': [3180], '8.3,': [3184], 'dNTPs)': [3199], 'annealed': [3201], '58': [3206], '(5′-CTTTGGCTTGATTGCGTAGAG-3′)': [3212], 'complementary': [3213], 'located': [3217], '5′-end': [3223, 3309], 'mRNA.': [3226], 'reverse': [3230], 'transcriptase': [3231], '42': [3239], 'final': [3243, 3461], 'phosphate': [3256], 'buffer.': [3257], 'templates': [3259, 4281], 'destroyed': [3261], 'RNase': [3265], 'formamide': [3271], '(20': [3274], 'terminate': [3277], 'reaction.': [3279], 'urea,': [3289], 'products': [3291], 'visualized': [3293], 'Silver': [3299], 'Sequence™': [3300], 'sequencing': [3302, 3317], 'system': [3303, 3431], 'verified': [3311], 'comparison': [3313], 'ladder': [3318], 'prepared': [3328, 3744], 'same': [3331], 'extension.': [3336], 'In-line': [3337], 'Probing': [3338], 'RNA—Values': [3340], 'half-maximal': [3343], 'dissociation': [3345], 'constant': [3346], '(apparent': [3347], 'KD)': [3348], 'each': [3350, 3416, 3878], 'construct': [3351], 'conducting': [3355], 'in-line': [3356], 'probing': [3357], 'wherein': [3360], 'varied': [3367], 'between': [3368], '0': [3369, 4173], 'μm.': [3372], 'Composite': [3373], 'plots': [3374], 'fraction': [3377], 'cleaved': [3380], 'versus': [3384], 'logarithm': [3386], 'generated': [3393, 3421], 'provide': [3395], 'estimate': [3397], 'KD.': [3401], 'Fraction-cleaved': [3402], 'values': [3403, 3413], 'normalized': [3405], 'relative': [3406], 'highest': [3409], 'lowest': [3411], 'site.': [3417], 'graphs': [3419], 'analyzed': [3423], 'Doc': [3427], '2000': [3428], 'documentation': [3430], 'quantification': [3433], 'software': [3434], 'Infectivity': [3437], 'Assays—PSTVd': [3438], 'partial': [3449], 'NaPO4,': [3456], '7.0,': [3458], 'pg/μl.': [3468], 'Aliquots': [3469], 'placed': [3474], 'carborundum-dusted': [3477], 'cotyledons': [3478], '7-day-old': [3480], 'tomato': [3481], '(Lycopersicon': [3482], 'esculentum': [3483], 'Mill': [3484], 'cv.': [3485], 'Rutgers)': [3486], 'seedlings': [3487, 3507], 'gently': [3489], 'rubbed': [3490], 'side': [3493], 'sterile': [3496], 'micropipette': [3497], 'tip.': [3498], 'Control': [3499], 'plants': [3500], 'inoculated': [3502], 'alone.': [3505], 'Inoculated': [3506], 'maintained': [3509], '4–6': [3511], 'weeks': [3512], 'greenhouse': [3515], 'under': [3516, 3649, 4288], 'suitable': [3518], 'replication': [3521], 'periodically': [3523], 'tested': [3524], 'progeny': [3530], 'dot-blot': [3532], 'hybridization': [3533], 'full-length,': [3535], 'digoxigenin-labeled': [3536], 'probes': [3538], '(+)PSTVd': [3541], '(34Podleckis': [3542], 'E.V.': [3543], 'Hammond': [3544], 'Hurtt': [3546], 'S.W.': [3547], 'Hadidi': [3548], 'Virol.': [3551], 'Methods.': [3552], '43:': [3554], '147-158Crossref': [3555], '(64)': [3558], 'Immunopurification': [3561], 'ME1—To': [3563], 'obtain': [3564], 'degree': [3569], 'purity': [3571], 'step,': [3575], 'affinity': [3579, 3620], 'approach': [3581], 'involving': [3582], 'anti-ME1': [3585], 'antibody.': [3586], 'antibody,': [3588], 'Scholar),': [3611, 3716], 'ligand': [3616], 'generate': [3618], 'matrix': [3621], 'via': [3622], 'coupling': [3623], 'Sepharose.': [3626], 'column,': [3637], 'linear': [3645], 'gradients': [3646], 'outlined': [3648], '"Experimental': [3650], 'Procedures."': [3651], 'As': [3652, 3769, 3943, 3954, 4155, 4313, 4502], 'Fig.': [3655, 3772, 3957, 4040, 4120, 4158, 4178, 4259, 4302, 4316, 4420, 4505], '1,': [3656], 'B,': [3659], 'peak': [3663], 'produced': [3664, 4045], 'two': [3670, 3717, 4150], 'bands.': [3672], 'bands': [3674], 'corresponded': [3675], '(30': [3678], 'kDa;': [3679, 3699], 'Ref.': [3680, 3700, 3855], '35Vepachedu': [3681], 'Bais': [3683], 'H.P.': [3684], 'Vivanco': [3685, 3757, 3862], 'Planta.': [3687], '2003;': [3688], '217:': [3689], '498-506Crossref': [3690], '(23)': [3693], 'ME2': [3697], '(27': [3698], '30Vivanco': [3701], 'roots.': [3727], 'chromatography,': [3734], 'confirmed': [3741], '(36Park': [3751], 'S.-W.': [3752, 3857], 'C.B.': [3754, 3859], 'Linden': [3755, 3860], '130:': [3762, 3867], '164-178Crossref': [3763, 3868], '(57)': [3766, 3871], '1C,': [3773], 'immunopurified': [3775, 3795], 'depurinated': [3777, 3920], 'released': [3783, 4057, 4270], 'diagnostic': [3785], '367-nucleotide': [3786], 'fragment': [3787, 4298], 'upon': [3788], 'treatment': [3789, 3979, 4126], 'aniline,': [3791, 3926], 'demonstrating': [3793], 'enzymatically': [3799], 'Activity': [3802, 4363], 'Partially': [3806], 'Denatured': [3807], 'Non-ribosomal': [3808], 'Substrates—As': [3809], 'first': [3811], 'step': [3812], 'understanding': [3814], 'examined': [3824, 4143], 'catalyzed': [3827], 'DNA,': [3837], 'isolated': [3839], 'And': [3843], 'PAP-H': [3846], '(RIP': [3847], 'pokeweed;': [3854], '36Park': [3856], 'Before': [3874], 'preheated': [3883], 'ranging': [3886], 'induce': [3893], 'modifications.': [3895], 'Non-covalent': [3896], 'stacking': [3904], 'stabilize': [3906], '(dsDNA)': [3909], 'disrupted': [3912], 'simply': [3914], 'raising': [3915], 'temperature.': [3917], 'When': [3918], 'undergoes': [3930], 'site(s)': [3934], 'depurination,': [3936], 'fragment(s)': [3940], 'released.': [3942], 'result,': [3945], 'amount': [3947], 'intact': [3949, 4017], 'quantitatively': [3952], 'decreases.': [3953], '2A,': [3958], 'fact': [3960, 4089], 'dsDNA': [3962, 4026], 'levels': [3963], 'affected': [3966], 'indicates': [3980], 'neither': [3983], 'depurinates': [3984, 4035], 'nor': [3985], 'degrades': [3986], 'dsDNA.': [3987], 'Increasing': [3988, 4208], 'even': [3995], 'resulted': [3998, 4070, 4200, 4215, 4246], '(ssDNA),': [4005], 'remained': [4009], 'undetectable.': [4010], 'quantitative': [4014], 'decrease': [4015], 'ssDNA': [4018, 4056, 4091, 4234], 'template': [4019], 'visible': [4020], 'electrophoretic': [4023, 4263, 4416], 'profiles': [4024, 4417], 'preincubated': [4027, 4457], 'showed': [4031, 4042, 4265, 4485], 'readily': [4034], 'ssDNA.': [4036], 'Data': [4037, 4175], 'presented': [4038, 4176], '2B': [4041], 'ssDNAs': [4044], '>80': [4047], 'susceptible': [4050, 4323, 4473], 'pretreatment': [4059], 'little': [4065, 4240], 'pg': [4067, 4243], 'detectable': [4072], '(Fig.': [4074, 4098, 4293], '2C).': [4075], 'Most': [4076], 'importantly,': [4077], 'both': [4084, 4219], 'rapid': [4085, 4249], 'spontaneous.': [4087], 'completed': [4094], '≤30': [4096], '2D)': [4099], 'allowed': [4100], 'assess': [4103], 'ME1-nucleic': [4104], 'able': [4112], 'refold': [4114], '(see': [4118], 'Supplemental': [4119, 4258], '1).': [4121], 'Throughout': [4122], 'alone': [4132], 'did': [4133], 'result': [4135], '(results': [4138], 'shown).': [4140], 'next': [4142], 'action': [4146], '3A': [4159], '(lanes': [4160], 'd': [4161], 'e),': [4163], 'deproteinized': [4169], 'stored': [4171], '3B': [4179, 4303], 'show,': [4180], 'however,': [4181, 4484], 'relatively': [4187], 'low': [4188], '°C)': [4194], 'exposure': [4197, 4237], 'rRNA.': [4207, 4225], '18': [4223], 'similar': [4229], 'those': [4231, 4456], 'obtained': [4232], 'substrates;': [4235], 'i.e.': [4236], '(≤30': [4250], 's)': [4251], '(data': [4255], 'provided': [4256], '2).': [4260], 'Interestingly,': [4261], 'pattern': [4264], 'ME1-depurinated': [4268], 'sizes': [4275], 'treatment.': [4278], 'Because': [4279], 'stable': [4283], 'up': [4284], '3A,': [4294], 'lanes': [4295], 'f–i),': [4296], 'patterns': [4299], 'indicate': [4304, 4330], 'sites.': [4312, 4443], '3C,': [4317], 'heat-treated': [4318], 'Taken': [4326], 'together,': [4327], '(i)': [4332], 'onset': [4333], 'closely': [4339], 'related': [4340], '(ii)': [4353], 'physically': [4357], 'random.': [4362], 'Single-stranded': [4368], 'Multiple': [4371], 'Adenines—To': [4372], 'examine': [4374], 'subjected': [4397], 'analysis': [4401], 'annealing': [4405], '5′': [4411], 'terminus.': [4412], 'Inspection': [4413], '4A': [4421], 'reveals': [4422], 'fragmentation': [4426], 'temperature-dependent.': [4429], 'Preincubation': [4430], '>45': [4436], 'led': [4438], 'modification/cleavage': [4440], 'greater': [4447], 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