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Title: $Effect of Exogenous Creatine Supplementation on Muscle PCr Metabolism
Abstract: 31P NMR was used to assess the influence of two weeks creatine supplementation (21 g · d-1) on resting muscle PCr concentration, on the rate of PCr repletion (Rdepl), and on the half-time of PCr repletion (t1/2). Body mass (BM) and volume of body water compartments were also estimated by impedance spectroscopy. Fourteen healthy male subjects (20.8 ± 1.9 y) participated in this double-blind study. PCr was measured using a surface coil placed under the calf muscle, at rest and during two exercise bout the duration of which was 1 min. They were interspaced by a recovery of 10 min. The exercises comprised of 50 plantar flexions-extensions against weights corresponding to 40 % and 70 % of maximal voluntary contraction (MVC), respectively. Creatine supplementation increased resting muscle PCr content by ∼20 % (P = 0.002). Rdepl was also increased by ∼15 % (P < 0.001) and ∼10 % (P = 0.026) during 40 % and 70 % MVC exercises, respectively. No change was observed in Rrepl and t1/2. BM and body water compartments were not influenced. These results indicate that during a standardized exercise more ATP is synthesized by the CK reaction when the pre-exercise level in PCr is higher, giving some support to the positive effects recorded on muscle performance.