Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2010122971', 'doi': 'https://doi.org/10.1093/cvr/18.10.639', 'title': 'Accentuated negative inotropism of verapamil after ischaemic intervention in isolated working rat heart', 'display_name': 'Accentuated negative inotropism of verapamil after ischaemic intervention in isolated working rat heart', 'publication_year': 1984, 'publication_date': '1984-10-01', 'ids': {'openalex': 'https://openalex.org/W2010122971', 'doi': 'https://doi.org/10.1093/cvr/18.10.639', 'mag': '2010122971', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6488233'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/cvr/18.10.639', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S91067379', 'display_name': 'Cardiovascular Research', 'issn_l': '0008-6363', 'issn': ['0008-6363', '1755-3245'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5036262026', 'display_name': 'Tsuyoshi Konishi', 'orcid': 'https://orcid.org/0000-0002-1019-625X'}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'T. KONISHI', 'raw_affiliation_strings': ['From the Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto 606, Japan'], 'affiliations': [{'raw_affiliation_string': 'From the Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto 606, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103069815', 'display_name': 'Yoshio Nakamura', 'orcid': 'https://orcid.org/0000-0003-2860-8600'}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Y. NAKAMURA', 'raw_affiliation_strings': ['From the Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto 606, Japan'], 'affiliations': [{'raw_affiliation_string': 'From the Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto 606, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036262026', 'display_name': 'Tsuyoshi Konishi', 'orcid': 'https://orcid.org/0000-0002-1019-625X'}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'T. KONISHI', 'raw_affiliation_strings': ['From the Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto 606, Japan'], 'affiliations': [{'raw_affiliation_string': 'From the Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto 606, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111652809', 'display_name': 'C Kawai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'C. KAWAI', 'raw_affiliation_strings': ['From the Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto 606, Japan'], 'affiliations': [{'raw_affiliation_string': 'From the Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto 606, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5111652809'], 'corresponding_institution_ids': ['https://openalex.org/I22299242'], 'apc_list': {'value': 4177, 'currency': 'EUR', 'value_usd': 4504, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.615891, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 77, 'max': 78}, 'biblio': {'volume': '18', 'issue': '10', 'first_page': '639', 'last_page': '644'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10217', 'display_name': 'Cardiac electrophysiology and arrhythmias', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10217', 'display_name': 'Cardiac electrophysiology and arrhythmias', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11057', 'display_name': 'Cardiac Ischemia and Reperfusion', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10378', 'display_name': 'Advanced MRI Techniques and Applications', 'score': 0.9897, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ventricular-pressure', 'display_name': 'Ventricular pressure', 'score': 0.5138019}], 'concepts': [{'id': 'https://openalex.org/C2777022698', 'wikidata': 'https://www.wikidata.org/wiki/Q410291', 'display_name': 'Verapamil', 'level': 3, 'score': 0.83985066}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.72071946}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.682973}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.6638111}, {'id': 'https://openalex.org/C2778921608', 'wikidata': 'https://www.wikidata.org/wiki/Q2002035', 'display_name': 'Ventricle', 'level': 2, 'score': 0.61029536}, {'id': 'https://openalex.org/C541997718', 'wikidata': 'https://www.wikidata.org/wiki/Q188151', 'display_name': 'Ischemia', 'level': 2, 'score': 0.5529905}, {'id': 'https://openalex.org/C155710745', 'wikidata': 'https://www.wikidata.org/wiki/Q575278', 'display_name': 'Inotrope', 'level': 2, 'score': 0.53222096}, {'id': 'https://openalex.org/C26635844', 'wikidata': 'https://www.wikidata.org/wiki/Q2002035', 'display_name': 'Ventricular pressure', 'level': 3, 'score': 0.5138019}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.4684945}, {'id': 'https://openalex.org/C146957229', 'wikidata': 'https://www.wikidata.org/wiki/Q1266915', 'display_name': 'Perfusion', 'level': 2, 'score': 0.45463365}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.32355645}, {'id': 'https://openalex.org/C519063684', 'wikidata': 'https://www.wikidata.org/wiki/Q706', 'display_name': 'Calcium', 'level': 2, 'score': 0.16533461}], 'mesh': [{'descriptor_ui': 'D003327', 'descriptor_name': 'Coronary Disease', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D009200', 'descriptor_name': 'Myocardial Contraction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D014700', 'descriptor_name': 'Verapamil', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003327', 'descriptor_name': 'Coronary Disease', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D003327', 'descriptor_name': 'Coronary Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003402', 'descriptor_name': 'Creatine Kinase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003402', 'descriptor_name': 'Creatine Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003864', 'descriptor_name': 'Depression, Chemical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009200', 'descriptor_name': 'Myocardial Contraction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010477', 'descriptor_name': 'Perfusion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011919', 'descriptor_name': 'Rats, Inbred Strains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014700', 'descriptor_name': 'Verapamil', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/cvr/18.10.639', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S91067379', 'display_name': 'Cardiovascular Research', 'issn_l': '0008-6363', 'issn': ['0008-6363', '1755-3245'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6488233', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3146021464', 'https://openalex.org/W2431200522', 'https://openalex.org/W2423534966', 'https://openalex.org/W2401766455', 'https://openalex.org/W2316957203', 'https://openalex.org/W2288298936', 'https://openalex.org/W2159831468', 'https://openalex.org/W2005991534', 'https://openalex.org/W1994212866', 'https://openalex.org/W1967650044'], 'abstract_inverted_index': {'We': [0], 'examined': [1], 'the': [2, 18, 38, 63, 67, 74, 82, 90, 99, 111, 118, 125, 178, 192, 196, 199, 208, 218, 226, 230], 'effects': [3], 'of': [4, 15, 21, 41, 44, 102, 167, 171, 203], 'a': [5, 56], 'clinically': [6], 'relevant': [7], 'concentration': [8], '(2': [9], 'X': [10], '10(-7)': [11], 'mol': [12], '.': [13, 158], 'litre-1)': [14], 'verapamil': [16, 106, 204, 242], 'on': [17], 'cardiac': [19, 248], 'functions': [20], 'isolated': [22], 'working': [23], 'rat': [24], 'hearts': [25], 'during': [26, 182, 195], 'global': [27], 'ischaemia': [28, 103, 172], '(15': [29], 'min)': [30], 'and': [31, 37, 55, 79, 104, 117, 224], 'reperfusion': [32], '(30': [33], 'min).': [34], 'The': [35, 184], 'aorta': [36], 'left': [39, 64, 68, 75, 83, 91, 112, 119, 147, 219], 'atrium': [40], 'each': [42], 'heart': [43], 'male': [45], 'Sprague-Dawley': [46], 'rats': [47], 'were': [48], 'cannulated': [49], 'for': [50], 'perfusion': [51], 'with': [52, 124, 238], 'Krebs-Henseleit': [53], 'solution,': [54], 'soft': [57], 'elastic': [58], 'catheter': [59], 'was': [60, 188, 205], 'introduced': [61], 'into': [62], 'ventricle': [65], 'through': [66], 'atrial': [69], 'cannula.': [70], 'Verapamil': [71], 'slightly': [72, 80], 'increased': [73], 'ventricular': [76, 84, 92, 113, 120, 131, 148, 220], 'end-diastolic': [77], 'pressure,': [78], 'decreased': [81], 'dP/dt,': [85], 'but': [86], 'did': [87], 'not': [88, 189], 'reduce': [89], 'peak': [93, 114, 132, 221], 'systolic': [94, 115, 133, 222], 'pressure': [95, 116, 134, 223], 'before': [96], 'ischaemia.': [97], 'During': [98], 'early': [100], 'phase': [101], 'reperfusion,': [105], '(n': [107, 127], '=': [108, 128], '6)': [109, 129], 'lowered': [110], 'dP/dt': [121, 149], 'in': [122, 174, 177, 191, 233, 247], 'comparison': [123], 'controls': [126], '(left': [130], '45.4': [135], '+/-': [136, 140, 151, 155], '16.9': [137], 'versus': [138, 153], '60.9': [139], '15.2': [141], 'mmHg:': [142], 'p': [143, 160], 'less': [144, 161], 'than': [145, 162], '0.05;': [146], '1256': [150], '484': [152], '2108': [154], '829': [156], 'mmHg': [157], 's-1:': [159], '0.05,': [163], 'after': [164], '30': [165], 'min': [166, 170], 'reperfusion).': [168], 'Fifteen': [169], 'resulted': [173], 'no': [175], 'increase': [176], 'creatine': [179, 185], 'kinase': [180, 186], 'release': [181, 187], 'reperfusion.': [183], 'different': [190], 'two': [193], 'groups': [194], 'experiment.': [197], 'Thus,': [198], 'negative': [200], 'inotropic': [201], 'effect': [202], 'accentuated': [206], 'by': [207, 216], 'ischaemic': [209], 'intervention.': [210], 'Myocardial': [211], 'protection': [212], 'may': [213, 243], 'be': [214], 'achieved': [215], 'reducing': [217], 'thereby': [225], 'oxygen': [227], 'consumption.': [228], 'On': [229], 'other': [231], 'hand,': [232], 'clinical': [234], 'application': [235], 'to': [236], 'patients': [237], 'extensive': [239], 'myocardial': [240], 'ischaemia,': [241], 'cause': [244], 'untoward': [245], 'deterioration': [246], 'functions.': [249]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2010122971', 'counts_by_year': [], 'updated_date': '2024-12-10T03:52:01.139007', 'created_date': '2016-06-24'}