Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2009725995', 'doi': 'https://doi.org/10.1074/jbc.m113.463679', 'title': 'Protein Phosphatase 2A and DNA-dependent Protein Kinase Are Involved in Mediating Rapamycin-induced Akt Phosphorylation', 'display_name': 'Protein Phosphatase 2A and DNA-dependent Protein Kinase Are Involved in Mediating Rapamycin-induced Akt Phosphorylation', 'publication_year': 2013, 'publication_date': '2013-05-01', 'ids': {'openalex': 'https://openalex.org/W2009725995', 'doi': 'https://doi.org/10.1074/jbc.m113.463679', 'mag': '2009725995', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23536185', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3650361'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m113.463679', 'pdf_url': 'http://www.jbc.org/article/S0021925819545537/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819545537/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100730907', 'display_name': 'Yikun Li', 'orcid': 'https://orcid.org/0000-0002-2117-8057'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yikun Li', 'raw_affiliation_strings': ['Departments of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322, USA.'], 'affiliations': [{'raw_affiliation_string': 'Departments of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322, USA.', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035869006', 'display_name': 'Xuerong Wang', 'orcid': 'https://orcid.org/0000-0002-3040-9435'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xuerong Wang', 'raw_affiliation_strings': ['Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101785893', 'display_name': 'Ping Yue', 'orcid': 'https://orcid.org/0000-0002-2919-1176'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ping Yue', 'raw_affiliation_strings': ['Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028543570', 'display_name': 'Hui Tao', 'orcid': 'https://orcid.org/0000-0002-6493-2101'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hui Tao', 'raw_affiliation_strings': ['Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088178599', 'display_name': 'Suresh S. Ramalingam', 'orcid': 'https://orcid.org/0000-0002-0757-3106'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Suresh S. Ramalingam', 'raw_affiliation_strings': ['Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015060656', 'display_name': 'Taofeek K. Owonikoko', 'orcid': 'https://orcid.org/0000-0002-7724-7728'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Taofeek K. Owonikoko', 'raw_affiliation_strings': ['Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101413535', 'display_name': 'Xingming Deng', 'orcid': 'https://orcid.org/0000-0003-0319-1511'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xingming Deng', 'raw_affiliation_strings': ['Department of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100341454', 'display_name': 'Ya Wang', 'orcid': 'https://orcid.org/0000-0001-6229-4495'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ya Wang', 'raw_affiliation_strings': ['Department of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072454821', 'display_name': 'Haian Fu', 'orcid': 'https://orcid.org/0000-0002-2362-7979'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Haian Fu', 'raw_affiliation_strings': ['Department of Pharmacology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059710197', 'display_name': 'Fadlo R. Khuri', 'orcid': 'https://orcid.org/0000-0002-8638-7618'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Fadlo R. Khuri', 'raw_affiliation_strings': ['Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5022570940', 'display_name': 'Shi‐Yong Sun', 'orcid': 'https://orcid.org/0000-0002-0117-8826'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shi-Yong Sun', 'raw_affiliation_strings': ['Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322', 'institution_ids': ['https://openalex.org/I150468666']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 2.43, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 53, 'citation_normalized_percentile': {'value': 0.8928, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '288', 'issue': '19', 'first_page': '13215', 'last_page': '13224'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10952', 'display_name': 'mTOR Signaling in Growth and Disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10952', 'display_name': 'mTOR Signaling in Growth and Disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10169', 'display_name': 'Molecular Mechanisms of Ras Signaling Pathways', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12104', 'display_name': 'Protein Tyrosine Phosphatases in Human Health and Disease', 'score': 0.994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rptor', 'display_name': 'RPTOR', 'score': 0.4971526}, {'id': 'https://openalex.org/keywords/pi3k/akt-pathway', 'display_name': 'PI3K/AKT pathway', 'score': 0.479694}, {'id': 'https://openalex.org/keywords/mtorc2', 'display_name': 'mTORC2', 'score': 0.45571306}], 'concepts': [{'id': 'https://openalex.org/C389152', 'wikidata': 'https://www.wikidata.org/wiki/Q6593007', 'display_name': 'Protein phosphatase 2', 'level': 4, 'score': 0.8105247}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.7853415}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.74988365}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.7487519}, {'id': 'https://openalex.org/C98490376', 'wikidata': 'https://www.wikidata.org/wiki/Q14876060', 'display_name': 'mTORC1', 'level': 4, 'score': 0.6948032}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.52595544}, {'id': 'https://openalex.org/C43060935', 'wikidata': 'https://www.wikidata.org/wiki/Q18043110', 'display_name': 'RPTOR', 'level': 4, 'score': 0.4971526}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4564713}, {'id': 'https://openalex.org/C107846503', 'wikidata': 'https://www.wikidata.org/wiki/Q14876061', 'display_name': 'mTORC2', 'level': 5, 'score': 0.45571306}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4533214}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.40785038}, {'id': 'https://openalex.org/C178666793', 'wikidata': 'https://www.wikidata.org/wiki/Q422476', 'display_name': 'Phosphatase', 'level': 3, 'score': 0.35653484}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.3128625}], 'mesh': [{'descriptor_ui': 'D000903', 'descriptor_name': 'Antibiotics, Antineoplastic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D051747', 'descriptor_name': 'DNA-Activated Protein Kinase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D054648', 'descriptor_name': 'Protein Phosphatase 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011499', 'descriptor_name': 'Protein Processing, Post-Translational', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020123', 'descriptor_name': 'Sirolimus', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000903', 'descriptor_name': 'Antibiotics, Antineoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002867', 'descriptor_name': 'Chromones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002867', 'descriptor_name': 'Chromones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003593', 'descriptor_name': 'Cytoplasm', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D003593', 'descriptor_name': 'Cytoplasm', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D003593', 'descriptor_name': 'Cytoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051747', 'descriptor_name': 'DNA-Activated Protein Kinase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D051747', 'descriptor_name': 'DNA-Activated Protein Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004357', 'descriptor_name': 'Drug Synergism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055785', 'descriptor_name': 'Gene Knockdown Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000076222', 'descriptor_name': 'Mechanistic Target of Rapamycin Complex 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009025', 'descriptor_name': 'Morpholines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009025', 'descriptor_name': 'Morpholines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D046912', 'descriptor_name': 'Multiprotein Complexes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019319', 'descriptor_name': 'Okadaic Acid', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019319', 'descriptor_name': 'Okadaic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054648', 'descriptor_name': 'Protein Phosphatase 2', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D054648', 'descriptor_name': 'Protein Phosphatase 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011499', 'descriptor_name': 'Protein Processing, Post-Translational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000076223', 'descriptor_name': 'Regulatory-Associated Protein of mTOR', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020123', 'descriptor_name': 'Sirolimus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m113.463679', 'pdf_url': 'http://www.jbc.org/article/S0021925819545537/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3650361', 'pdf_url': 'https://europepmc.org/articles/pmc3650361?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650361', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23536185', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m113.463679', 'pdf_url': 'http://www.jbc.org/article/S0021925819545537/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.77, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1268281962', 'https://openalex.org/W1668086213', 'https://openalex.org/W1970188754', 'https://openalex.org/W1972236331', 'https://openalex.org/W1979303367', 'https://openalex.org/W1983698019', 'https://openalex.org/W1988173009', 'https://openalex.org/W2005496215', 'https://openalex.org/W2008720923', 'https://openalex.org/W2009364489', 'https://openalex.org/W2011424260', 'https://openalex.org/W2013807892', 'https://openalex.org/W2017018900', 'https://openalex.org/W2018634307', 'https://openalex.org/W2020632741', 'https://openalex.org/W2020731274', 'https://openalex.org/W2021012077', 'https://openalex.org/W2023258120', 'https://openalex.org/W2023877093', 'https://openalex.org/W2025391287', 'https://openalex.org/W2029059439', 'https://openalex.org/W2029098356', 'https://openalex.org/W2036691369', 'https://openalex.org/W2043226961', 'https://openalex.org/W2050129566', 'https://openalex.org/W2051289805', 'https://openalex.org/W2059823430', 'https://openalex.org/W2065322400', 'https://openalex.org/W2073067473', 'https://openalex.org/W2077230170', 'https://openalex.org/W2082013812', 'https://openalex.org/W2090850110', 'https://openalex.org/W2094399892', 'https://openalex.org/W2099544753', 'https://openalex.org/W2101400486', 'https://openalex.org/W2102148658', 'https://openalex.org/W2102839088', 'https://openalex.org/W2110059026', 'https://openalex.org/W2111352469', 'https://openalex.org/W2112639893', 'https://openalex.org/W2112767263', 'https://openalex.org/W2124645897', 'https://openalex.org/W2124995142', 'https://openalex.org/W2126783165', 'https://openalex.org/W2137653823', 'https://openalex.org/W2143254803', 'https://openalex.org/W2144323242', 'https://openalex.org/W2150634191', 'https://openalex.org/W2153536914', 'https://openalex.org/W2154871907', 'https://openalex.org/W2167063082', 'https://openalex.org/W4238567307'], 'related_works': ['https://openalex.org/W4361239203', 'https://openalex.org/W4292092803', 'https://openalex.org/W2550775385', 'https://openalex.org/W2499779639', 'https://openalex.org/W2159714906', 'https://openalex.org/W2154106855', 'https://openalex.org/W2054117275', 'https://openalex.org/W2035521247', 'https://openalex.org/W1994186909', 'https://openalex.org/W1487550568'], 'abstract_inverted_index': {'Inhibition': [0, 174], 'of': [1, 4, 58, 81, 86, 93, 103, 135, 149, 175, 178, 232, 255, 260, 267, 277, 309, 323], 'mammalian': [2, 176], 'target': [3, 177], 'rapamycin': [5, 75, 107, 125, 179, 249, 281, 299], 'complex': [6, 180], '1': [7, 181], '(mTORC1),': [8, 182], 'for': [9, 183], 'example': [10, 184], 'with': [11, 60, 185, 234], 'rapamycin,': [12, 186], 'increases': [13, 187], 'Akt': [14, 40, 72, 100, 130, 142, 188, 214, 246, 274, 304, 316], 'phosphorylation': [15, 41, 189, 215], 'while': [16, 190], 'inhibiting': [17, 191], 'mTORC1': [18, 192], 'signaling.': [19, 193], 'However,': [20, 194], 'the': [21, 94, 147, 195, 268, 321], 'underlying': [22, 38, 196, 212], 'mechanisms': [23, 197], 'have': [24, 198], 'not': [25, 140, 199, 314], 'been': [26, 200], 'fully': [27, 201], 'elucidated.': [28, 202], 'The': [29, 203], 'current': [30, 204], 'study': [31, 205], 'has': [32, 206], 'uncovered': [33, 207], 'a': [34, 163, 208, 337], 'previously': [35, 209], 'unknown': [36, 210], 'mechanism': [37, 211], 'rapamycin-induced': [39, 71, 99, 117, 213, 245, 273, 291], 'involving': [42, 216], 'protein': [43, 48, 217, 222], 'phosphatase': [44, 218], '2A': [45, 219], '(PP2A)-dependent': [46, 220], 'DNA': [47, 221], 'kinase': [49, 223], '(DNA-PK)': [50, 224], 'activation.': [51, 225], 'In': [52, 226], 'several': [53, 227], 'cancer': [54, 104, 150, 169, 228, 278, 324, 343], 'cell': [55, 229], 'lines,': [56, 230], 'inhibition': [57, 80, 115, 134, 231, 254, 289, 308], 'PP2A': [59, 68, 77, 114, 233, 242, 251, 288], 'okadaic': [61, 235], 'acid,': [62, 236], 'fostriecin,': [63, 237], 'small': [64, 238], 'T': [65, 239], 'antigen,': [66, 240], 'or': [67, 84, 91, 241, 258, 265], 'knockdown': [69, 83, 243, 257], 'abrogated': [70, 244], 'phosphorylation,': [73, 247], 'and': [74, 111, 128, 137, 144, 155, 248, 285, 302, 311, 318, 329], 'increased': [76, 108, 250, 282], 'activity.': [78, 119, 252, 293], 'Chemical': [79, 253], 'DNA-PK,': [82, 256], 'deficiency': [85, 259], 'DNA-PK': [87, 95, 109, 118, 138, 261, 269, 283, 292, 312], 'catalytic': [88, 262], 'subunit': [89, 263], '(DNA-PKcs),': [90, 264], 'knock-out': [92, 266], 'component': [96, 270], 'Ku86': [97, 271], 'inhibited': [98, 146, 272, 320], 'phosphorylation.': [101, 131, 275, 305], 'Exposure': [102, 276], 'cells': [105, 151, 279, 325], 'to': [106, 166, 280, 340], 'activity,': [110, 284], 'gene': [112, 286], 'silencing-mediated': [113, 287], 'attenuated': [116, 290], 'Collectively': [120, 294], 'these': [121, 295], 'results': [122, 296], 'suggest': [123, 162, 297, 336], 'that': [124, 298], 'induces': [126, 300], 'PP2A-dependent': [127, 301], 'DNA-PK-mediated': [129, 303], 'Accordingly,': [132, 306], 'simultaneous': [133, 307], 'mTOR': [136, 310], 'did': [139, 313], 'stimulate': [141, 315], 'activity': [143, 317], 'synergistically': [145, 319], 'growth': [148, 322], 'both': [152, 326], 'in': [153, 156, 327, 330], 'vitro': [154, 328], 'vivo.': [157, 331], 'Thus,': [158, 332], 'our': [159, 333], 'findings': [160, 334], 'also': [161, 335], 'novel': [164, 338], 'strategy': [165, 339], 'enhance': [167, 341], 'mTOR-targeted': [168, 342], 'therapy': [170, 344], 'by': [171, 345], 'co-targeting': [172, 346], 'DNA-PK.': [173, 347]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2009725995', 'counts_by_year': [{'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-08-15T05:33:20.343179', 'created_date': '2016-06-24'}